JP2007262100A - Method for preventing reduction in content of terpenoid - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To prevent reduction in the content of a terpenoid in a terpenoid-containing nasal drop charged in a spray container. <P>SOLUTION: This method for preventing reduction in the content of a terpenoid is characterized by charging a terpenoid-containing nasal drop in a spray container whose inner wall material in contact with the terpenoid-containing nasal drop on the charging of the drop is an epoxy resin such as an epoxy phenolic resin, a polyamideimide resin, or a fluororesin, such as a vinylidene fluoride resin. According to the present invention, the terpenoid-containing nasal drop charged in the container can be preserved without accompanying the remarkable content reduction of the terpenoid. <P>COPYRIGHT: (C)2008,JPO&INPIT

Description

  The present invention relates to a nasal preparation filled in a specific container.

  In order to relieve nasal inflammation such as nasal congestion and nasal congestion, nasal drops containing terpenoids such as menthol as a cooling agent in addition to conventional antihistamines, bactericides, vasoconstrictors, etc. are used. Commercially available manually pressurized spray containers are filled.

  As a result of our research, when nasal drops containing terpenoids are filled in a spray container made of polyethylene or polypropylene, the terpenoids cannot absorb and permeate into the container material during storage and keep its content for a long time. understood. The present invention is intended to enable long-term storage by suppressing terpenoid absorption penetration and volatilization from a terpenoid-containing nasal preparation filled in a spray container.

  The present invention is a nasal preparation prepared by filling a terpenoid-containing nasal drop into a spray container in which the material of the inner wall surface that comes into contact with the drug at the time of drug filling is an epoxy resin, a polyamide-imide resin, or a fluororesin.

  ADVANTAGE OF THE INVENTION According to this invention, it can suppress that the content of the terpenoid in the terpenoid containing nasal drop with which the spray container was filled reduces during a preservation | save.

  Terpenoids include monoterpenes, sesquiterpenes, diterpenes, examples of which include menthol, borneol, camphor, geraniol, cineol, anethole, limonene, eugenol, eucalyptus oil, farnesol, nerolidol, phytol or semblene. . Preference is given to menthol, borneol, camphor, eucalyptus oil and the like.

  Terpenoids can be blended in nasal drops with other components selected as necessary, for example, vasoconstrictors, antihistamines, bactericides, anti-inflammatory agents, local anesthetics, antiallergic agents, astringents and the like.

  In the present invention, examples of the epoxy resin that is a material forming the inner wall surface in contact with the filling agent of the spray container include an epoxy phenol resin, and examples of the fluororesin include a vinylidene fluoride resin. In order to form the inner wall surface in contact with the filling drug in the spray container with these resins, the drug filling part itself may be made of these resins, or the inner wall surface may be painted with these resins to form a resin film. May be. These resin surfaces prevent absorption and volatilization of terpenoids in the filled nasal drops, and can suppress a decrease in the content thereof.

Spray containers include manual or automatic spray containers. In the case of the automatic injection type, a compressed gas such as compressed air can be used instead of a liquefied gas such as Freon or LPG.
The invention is further described below in the form of examples.

Test solution (nasal drops)
[Prescription]
Tetrahydrozoline hydrochloride 0.1g
Chlorpheniramine maleate 0.5g
Benzethonium chloride 0.02g
Lidocaine 0.5g
L-Menthol 0.015g
Eucalyptus oil 0.005g
Hydrochloric acid appropriate amount sodium hydroxide appropriate amount purified water appropriate amount

(PH 6.0) Total 100ml

〔Test method〕
Each aluminum can in which 5 ml of the test solution is put in a polyethylene and polypropylene container (capacity 5.5 ml), respectively, and the inner wall surface is coated with epoxyphenol, polyamideimide or vinylidene fluoride resin as an inner surface coating agent. Each container (capacity: 15 ml) was filled with 14 ml of the test solution and compressed air (6.5 Kg / cm ² ) to be airtight, allowed to stand at room temperature and stored. After 4 weeks, the residual amounts of l-menthol and eucalyptus oil in each test solution were measured by gas chromatography. The results are shown in the table below.

〔Test results〕
Residual rate (unit:%)

  As is apparent from the table, in the polyethylene container, l-menthol and eucalyptus oil do not remain, and in the polypropylene container, the residual ratios are only 15.6% and 16.5%, respectively. On the other hand, in the container in which epoxyphenol, polyamideimide or vinylidene fluoride resin was applied to the inner wall surface, the residual ratios were 65.2 to 67.1% and 76.3 to 78.9%, respectively. From this result, it can be seen that the decrease in the terpenoid content in the drug filled in the container having the inner wall surface formed of epoxyphenol, polyamideimide, and vinylidene fluoride resin is markedly suppressed.

  According to the present invention, since the terpenoid content in the terpenoid-containing nasal drops filled in the spray container can be suppressed during the storage, the terpenoid content during the storage is reduced. The nasal drops can be produced without any problems.

Claims (3)

  A terpenoid during storage of a spray, characterized in that a nasal drop containing terpenoid is filled in a spray container in which an inner wall surface in contact with the container is made of epoxy resin, polyamideimide resin or fluororesin. Content reduction control method.   The suppression method according to claim 1, wherein the inner wall surface is an epoxy resin, a polyamideimide resin, or a fluororesin.   The suppression method according to claim 1, wherein the epoxy resin is an epoxy phenol resin and the fluororesin is a vinylidene fluoride resin.