JP2007222537A - X-ray measurement apparatus and subject testing method - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To extremely correctly recognize relation between measurement result data and a subject by effectively utilizing information storage ability in an X-ray measurement apparatus using a chip with the information storage ability. <P>SOLUTION: The X-ray measurement apparatus includes: an X-ray measurement part 5 for irradiating the subject 4 at a measurement position with X-rays generated from an X-ray source and detecting the X-rays passing through the subject 4 by an X-ray detector; the chip 6 fixed to the subject so as to store information concerning the subject 4; a reader/writer 7 for exchanging signals with the chip 6; a storage medium 26 for storing the data; and a control part 2 for allowing the storage medium 26 to store the measurement result data, which is obtained by measurement using the X-ray measurement part 5, and measurement-related data corresponding to the measurement result data, in connection with subject identification data stored in the data storage part in the chip 6, and writing the measurement-related data in a data writing area in the chip 6. <P>COPYRIGHT: (C)2007,JPO&INPIT

Description

  The present invention relates to an X-ray measuring apparatus that measures X-rays transmitted through a specimen. The present invention also relates to a specimen inspection method performed using the X-ray measurement apparatus.

  Various apparatuses such as an X-ray CT (Computed Tomography) apparatus, an X-ray apparatus, an X-ray bone density measuring apparatus, and the like have been conventionally known as X-ray measuring apparatuses that measure X-rays transmitted through a specimen (for example, Patent Documents). 1). In this type of X-ray measurement apparatus, conventionally, there has been known an apparatus in which a plurality of metal rings are attached to a specimen in a manner unique to the specimen to form a barcode, and this barcode is used as a specimen identification mark. (For example, refer to Patent Document 2).

  Moreover, although it is not an apparatus using X-rays, an apparatus for performing an inspection by embedding an IC tag in a small animal is known (for example, see Patent Document 3). Further, a technique is known in which data relating to a specimen is stored in a wireless tag in an inspection apparatus using X-rays and the wireless tag is attached to a test result (for example, see Patent Document 4).

JP 2006-038836 (5th page, FIG. 2) Japanese Patent Laying-Open No. 2005-189023 (page 7, FIG. 3) JP 2002-058648 (3rd page, FIG. 1) JP2005-111254 (4th page, FIG. 1)

  In the apparatus disclosed in Patent Document 2, since the metal ring does not have information storage capability, measurement related data (for example, measurement date data, measurement conditions) corresponding to measurement result data such as X-ray intensity data, reconstruction data, and the like. Data) cannot be stored in an identification element such as a metal ring. Therefore, when using an identification element such as a metal ring to confirm the reliability of measurement result data, only the specimen identification code is relied upon. Therefore, the reliability of confirming which sample corresponds to the measurement result data stored in the computer is insufficient.

  In addition, in the apparatus disclosed in Patent Document 3, it is disclosed that the specimen is identified by the ID number stored in the IC tag, but it is not disclosed that X-ray measurement is performed on the specimen. Although it is disclosed that an ID number is used in conducting an experiment, it is not disclosed that information related to an experiment result (for example, experiment date and experiment condition) is stored in an IC tag. Therefore, even in the apparatus disclosed in Patent Document 3, the reliability regarding which sample corresponds to the test result data stored in the computer is insufficient.

  In the apparatus disclosed in Patent Document 4, two wireless tags are attached to one image film, and the reliability of the image film is checked by confirming the coincidence of data in the wireless tags. Technology is disclosed. Further, it is disclosed that such wireless tags store diagnosis results such as fractures, film storage locations, and the like. The diagnosis result in this case corresponds to the measurement result data, and the film storage location data is data unrelated to the measurement result data such as the diagnosis result. As described above, the apparatus disclosed in Patent Document 4 discloses a technique for inspecting an image film using a wireless tag, but effectively uses measurement-related data such as a shooting date, A technique for accurately confirming the correspondence relationship with the specimen is not disclosed.

  The present invention has been made in view of the above-described problems, and effectively utilizes the information storage capability of a chip having information storage capability to obtain measurement result data ( For example, an object of the present invention is to make it possible to recognize the relationship between X-ray intensity data and reconstruction data obtained by integrating it) and a specimen very accurately.

  An X-ray measurement apparatus according to the present invention includes an X-ray measurement unit that irradiates a specimen placed at a measurement position with X-rays generated from an X-ray source and detects X-rays transmitted through the specimen by an X-ray detection unit. And a chip that is fixed to the sample and stores information related to the sample, and a reader / writer that transmits and receives signals to and from the chip. The chip includes a data storage unit, a data reception unit, a data transmission unit, and a power supply unit that generates power based on an external signal. The data storage unit has an area for storing specimen identification data and a data writing area in which data can be written. The reader / writer includes a data receiving unit that receives a signal output from a data transmitting unit in the chip, a data transmitting unit that transmits a signal toward the data receiving unit in the chip, and a power supply unit in the chip. And a power signal transmission unit that transmits the signal toward. The X-ray measurement apparatus according to the present invention further includes a storage unit that stores data, and a control unit that stores data in both the storage unit and the data writing area in the chip. The measurement result data obtained by the measurement using the X-ray measurement means and the measurement related data corresponding to the measurement result data are stored in association with the specimen identification data stored in the data storage unit in the chip. And storing the measurement related data in a data writing area in the chip.

  In the above configuration, “measurement result data” refers to data directly obtained as a result of measurement by an X-ray measurement apparatus during X-ray measurement, so-called raw data. For example, if the X-ray measurement is to measure the intensity of the X-ray transmitted through the specimen with respect to each of the X-ray incidence angles while varying the X-ray incidence angle with respect to the specimen, the individual X-ray incidence is performed. X-ray intensity data output from the X-ray detection means at an angle is measurement result data. In the current X-ray measuring apparatus, the X-ray incident angle is changed to about n ways and the measurement is performed. Therefore, as the measurement result data, the same number of X-ray intensity data as the types of X-ray incident angles can be obtained. .

  The “measurement result data” includes data obtained by performing some editing on the data obtained directly as a result of the measurement as described above. As the data subjected to such editing, for example, data obtained by integrating the above-mentioned n types of X-ray intensity data, so-called reconstruction data, can be considered. The measurement result data also includes data obtained as a result of adding some calculation other than integration, for example, averaging, to a plurality of X-ray intensity data.

  The “measurement related data” is data accompanying the above measurement result data, and is used for the purpose of defining the measurement result data in any sense. For example, measurement date data and measurement condition data are considered as measurement related data. The “measurement conditions” include, for example, the intensity of X-rays incident on the specimen, the name of the X-ray filter placed in front of the specimen, the temperature at the time of measurement, and the humidity at the time of measurement. The intensity of X-rays can be defined by the tube voltage and tube current in the X-ray generator.

  In addition, the “specimen” may be a small animal or a substance other than an animal. Moreover, a mouse | mouth etc. can be considered as a small animal.

  According to the X-ray measurement apparatus of the present invention, a specific sample can be accurately selected from a plurality of samples, and X-ray measurement can be performed a plurality of times over a long period of time for the sample. In other words, a specific sample can be definitely selected from a plurality of samples, and the sample can be observed for a long period of time.

  Further, the chip used in the X-ray measuring apparatus according to the present invention is, for example, an IC chip, and this type of chip can be easily and firmly fixed to an arbitrary place on the outer skin of a small animal. For example, it may be tied by a string-like member or fixed by an adhesive. It can also be embedded under the skin of a small animal. At present, an environment is set up in which anyone can easily insert a tip under the skin of a small animal using an insertion device having a structure similar to a syringe. The position to be embedded is not particularly limited, but preferably a position that does not affect the experiment is selected. For example, the neck, the shoulder, the limbs, and the like are selected.

  If the chip is embedded in the specimen, it is possible to prevent the chip from being stained or damaged due to dust, dust, etc., so that the predetermined characteristics of the chip can be maintained over a long period of time. According to the X-ray measurement apparatus of the present invention, the chip can be firmly fixed to the specimen as described above, so that stable reading and writing of data can always be performed on the chip.

  In the X-ray measurement apparatus according to the present invention, when the X-ray measurement is completed, measurement-related data (for example, measurement date, measurement condition) is stored in the storage means together with the measurement result data (for example, reconstruction data). The At the same time, measurement-related data is stored in the data storage unit in the chip in addition to the specimen identification data. Thus, since measurement related data is stored in both the storage means storing the measurement result data and the data storage unit in the chip, the measurement result data stored in the storage means corresponds to which sample. When confirming that, it is possible to use not only specimen identification data but also measurement related data as a reference for confirmation. For this reason, it is possible to certify which sample the measurement result data stored in the storage means corresponds to more accurately than in the case of certifying only by using the sample identification data. In addition, for example, when measurement-related data (for example, measurement date, measurement condition) in the storage means is accidentally changed or deliberately altered, the measurement-related data stored in the data storage unit in the chip By comparing with the data, the change or the like can be recognized immediately and clearly, and the reliability of the data can be kept high.

  Next, in the X-ray measurement apparatus according to the present invention, the X-ray measurement means varies the X-ray incident angles with respect to the specimen and calculates the intensity distribution of the X-rays transmitted through the specimen for each X-ray incident angle. It is a means to measure. The measurement result data is X-ray intensity distribution data obtained by the X-ray detection means for each X-ray incident angle, or reconstruction data obtained by integrating the individual X-ray intensity distribution data. It is desirable that

  This type of X-ray measurement apparatus is an apparatus that is suitably used for observing a specimen over a long period of time. When performing follow-up observation, it is necessary to repeatedly select a specific sample from a plurality of samples and then perform X-ray measurement repeatedly. In that case, the X-ray measurement apparatus according to the present invention is required. As described above, an apparatus that can very accurately recognize the correspondence between the measurement result data stored in the storage means and the specimen is very advantageous.

  Next, in the X-ray measurement apparatus according to the present invention, the measurement related data is measurement date data on which measurement is performed or measurement condition data related to measurement, and the measurement condition data includes irradiation X-ray intensity, filter name used, The measurement temperature or measurement humidity is desirable. Each of the above data is very effective data for indicating measurement result data such as reconstruction data. Therefore, if these data are used as measurement-related data, it is possible to more accurately identify which sample the measurement result data stored in the storage means corresponds to.

  Next, the X-ray measurement apparatus according to the present invention further includes an image calculation unit that generates an image signal based on an output signal of the X-ray detection unit, and an image display unit that displays an image based on the image signal. Preferably, the image calculation means generates an image signal based on both the measurement result data and measurement related data belonging to the same sample identification data as the sample identification data corresponding to the measurement result data.

  According to this configuration, when measurement result data such as reconstruction data is displayed on the screen of the image display means, in addition to the measurement result data, measurement related data (measurement date, irradiation X-ray intensity, use Filter, etc.) will also be displayed on the screen. Therefore, a lot of data can be provided to the observer when observing the measurement result, and therefore the observer can perform accurate observation.

  Next, an X-ray measurement apparatus according to the present invention includes an image calculation unit that generates an image signal based on an output signal of the X-ray detection unit, an image display unit that displays an image based on the image signal, Image data storage means for storing the image signal generated by the image calculation means in association with the search key data, and one or more images based on the search key data from the image signal stored in the image data storage means It is desirable to have image display control means for selecting a signal and transmitting the selected image signal to the image display means.

  According to this configuration, not only the current photographing data but also previous data of the same individual and data of other individuals can be displayed on the screen of the image display means. The screen display method in this case is not limited to a specific one. For example, a plurality of displays are displayed in a superimposed manner, a plurality of displays are displayed side by side, or a new one is overwritten on a plurality of old ones. Can be displayed.

  In addition, when using search key data like the aspect of this invention, it is desirable that the search key data is the said specimen identification data or measurement related data. In this way, for example, measurement result data with the same search identification data and different measurement dates can be displayed on the screen one after another, measurement result data of the same measurement date with different samples can be displayed on the screen one after another, Measurement result data of different specimens under the same measurement conditions can be displayed on the screen one after another. Thus, being able to easily compare and observe a lot of measurement result data on the screen is very effective in improving the accuracy of observation.

  Next, the X-ray measurement apparatus according to the present invention includes a sample table that supports the sample, and a sample table moving unit that moves the sample table between the measurement position and a retracted position away from the measurement position. It is desirable to have more. In general, the measurement position is often set inside the X-ray measurement apparatus, and around the measurement position, an X-ray generation apparatus, an X-ray detection apparatus, an apparatus for rotationally driving these apparatuses, Various other devices, wiring, and the like are provided. Therefore, it is very difficult for the measurer to place the sample directly at the measurement position. In addition, it is very difficult for the measurer to perform some processing on the specimen at the measurement position, for example, to perform treatment such as medication on a small animal that is the specimen. On the other hand, if the sample stage can be moved between the measurement position and the retracted position as in the aspect of the present invention, the necessary processing for the sample is performed at the retracted position having a space, and then the sample stage is performed. By moving the to the measurement position, the specimen can be correctly placed at the predetermined measurement position.

  Next, in the X-ray measurement apparatus according to the present invention, the power signal of the reader / writer data receiving unit, the reader / writer data transmitting unit, and the reader / writer may be at any position between the measurement position and the position where the chip is retracted. It is desirable to arrange the signal at a position where signals can be transmitted to and received from the chip. According to this configuration, the information in the chip can be automatically read and information can be automatically written in the chip while the observer moves the sample from the retracted position to the measuring position. . Further, although there is little spatial margin at the measurement position, there is a sufficient spatial margin between the measurement position and the retracted position, which is advantageous in that the degree of freedom for installing the reader / writer is increased.

  Next, in the X-ray measurement apparatus according to the present invention, when the specimen is an animal, the data writing area in the data storage section in the chip is (1) an area for storing data of drug names administered to the specimen. (2) an area for storing data on the date and time of administration to the specimen, (3) an area for storing data on the dosage to the specimen, (4) an area for storing data on the size of the lesion of the specimen, And (5) an area for storing data of date and time when the lesion size of the specimen is input.

  In this configuration, each of the above data is stored in the data storage unit in the specimen itself, instead of storing each of the above data in a storage unit (for example, a computer storage medium) in the X-ray measurement apparatus. That is. According to this configuration, it is possible to obtain an effect that the history regarding the specimen can be known between different computers.

  Next, in the specimen testing method according to the present invention, after using the X-ray measuring apparatus having the above-described configuration, (1) the chip is continuously attached to each of a plurality of specimens; A specific sample is selected based on the sample identification data stored in the chip, and (3) the selected sample is measured a plurality of times using the X-ray measuring means, and each measurement is performed. Measurement result data is obtained, and (4) the measurement result data is observed to observe temporal changes of the specimen.

  According to this inspection method, a specific sample can be selected from a plurality of samples, and the sample can be followed up. According to the method of the present invention, the operation of selecting a specific sample from a plurality of samples can be performed very accurately by the combination of the chip and the reader / writer, so that very reliable follow-up data can be obtained. it can.

  Next, in the sample testing method according to the present invention, (1) the selected sample is subjected to a plurality of processes over time, and (2) the measurement is performed using X-ray measurement means after those processes. It is desirable to provide a process of performing measurement and obtaining measurement result data in each measurement. Here, “processing” refers to performing some action on the specimen or holding the specimen in a state where no action is performed. Specifically, the following actions are performed on the specimen, for example, applying a load, applying heat, cooling, applying vibration, or irradiating light. In particular, when the specimen is an animal, medication, surgery or the like can be considered as the processing.

  According to the aspect of the present invention, it is possible to perform follow-up after some processing on the specimen. According to the present invention, it is possible to reliably prevent the sample from being mixed by the combination of the chip and the reader / writer, and therefore it is possible to perform very accurate follow-up observation.

  Hereinafter, an X-ray measuring apparatus according to the present invention will be described based on embodiments. Of course, the present invention is not limited to this embodiment. In the following description, the drawings are referred to. In the drawings, the components may be shown in different ratios from the actual ones in order to show the characteristic parts in an easy-to-understand manner.

  FIG. 1 shows an embodiment of an X-ray measuring apparatus according to the present invention. In the present embodiment, the present invention is applied to an X-ray CT apparatus which is an example of an X-ray measurement apparatus. In the present embodiment, a case where measurement is performed using an X-ray CT apparatus using a mouse, which is a small animal, as a specimen is illustrated.

  In FIG. 1, an X-ray CT apparatus 1 includes a control unit 2 configured by a computer, a display 3 as a display unit, an X-ray measurement unit 5 that performs measurement on a sample 4 using X-rays, and a sample. 4, a chip 6 fixed in 4 (embedded in the specimen in this embodiment), a reader / writer 7 that transmits and receives signals to the chip 6 in a wireless manner, and an input device 8 that is used when an operator inputs data. Have. Reference numeral 9 denotes a bus for transmitting signals between the elements.

  The display 3 is an electronic device that inputs an image signal and displays an image on a screen, and is configured by, for example, a CRT (Cathode Ray Tube) display or a flat panel display (for example, a liquid crystal display device). A VRAM (video ram) 12 that generates an image signal for one frame of the screen and supplies the image signal to the display 3 is provided at the front stage of the display 3.

  As shown in FIG. 2, the X-ray measurement unit 5 includes a sample table 13 on which a mouse 4 as a sample is placed, an X-ray generator 14 provided on one side of the sample table 13, and the other of the sample table 13. And an X-ray detector 15 provided on the side. The chip 6 of FIG. 1 is embedded under the skin of the mouse 4 placed on the specimen table 13, that is, in the body using a predetermined injector. The burying position is appropriately selected according to the type of examination, and for example, the back of a mouse can be considered. The chip 6 may be fixed to the body surface instead of being embedded in the body. As a fixing method in this case, adhesion using an adhesive or fastening using a string-like member can be considered.

  The X-ray generator 14 has an X-ray source F that emits X-rays. The X-ray source F is configured to include, for example, a filament that generates heat and emits thermoelectrons when energized, and a target that is disposed to face the filament. An area where the thermoelectrons emitted from the filament collide with the surface of the target is an X-ray focal point, and X-rays are emitted from this X-ray focal point. Thus, the X-ray focal point forms the X-ray source F. The X-ray R0 emitted from the X-ray source F is irradiated to a wide area of the specimen 4.

  The target is formed of, for example, W (tungsten). In this case, X-rays having a wavelength unique to W are generated from the X-ray source F. The intensity of the X-ray generated from the X-ray source F is determined by the current flowing through the circuit constituted by the filament and the target (so-called tube current) and the voltage applied between the filament and the target (so-called tube voltage). It depends on. The power supply circuit attached to the X-ray generator 14 is designed so that, for example, an appropriate current of 1 mA or less flows as a tube current and a voltage of about 30 kV is applied as a tube voltage.

  The X-ray detector 15 is configured using a two-dimensional X-ray detector that detects X-rays in a planar manner, for example, a two-dimensional CCD (Charge Coupled Device) sensor. As is well known, the two-dimensional CCD sensor is a two-dimensional X-ray sensor in which a plurality of CCD elements are arranged in a matrix in a vertical and horizontal plane. The X-ray detector 15 can capture the X-ray R1 transmitted through the specimen 4 in a planar shape. By detecting individual output signals of a plurality of CDD elements arranged in a matrix in the plane, the X-ray intensity distribution in the plane of the transmitted X-ray R1 can be known. The X-ray intensity calculation circuit 17 connected to the output terminal of the X-ray detector 15 generates such an in-plane X-ray intensity distribution signal I (x, y) by calculation and outputs it as a signal.

  The sample table 13 on which the sample 4 is placed is driven by the table moving device 16 and reciprocates linearly as indicated by an arrow A between the measurement position P1 and the retracted position P2. The measurement position P1 is a position at which the X-ray R0 emitted from the X-ray source F enters the specimen 4 supported by the specimen table 13. The retreat position P2 is a position away from the X-ray optical axis (that is, the central axis line of X-rays emitted from the X-ray source F) X0.

  In general, the X-ray generator 14 and the X-ray detector 15 are often surrounded by a metal or plastic casing 18 so as not to be seen from the outside. Since the external shape of the casing 18 can be arbitrarily set, the casing 2 is schematically drawn by a chain line in FIG. When the X-ray generator 14 and the X-ray detector 15 are thus covered with the casing 18, the measurement position P <b> 1 is located inside the casing 18, and the retracted position P <b> 2 is located outside the casing 18. An opening 19 is provided in the front surface of the casing 18, and the sample table 13 and the sample 4 supported thereon are driven by the table moving device 16 and are carried from the retracted position P 2 through the opening 19 to the measurement position P 1. .

  Since the measurement position P1 is inside the casing 18, it is difficult for the operator to act on the specimen 4 when the specimen 4 is in this position. However, if the sample stage 13 is pulled out to the retracted position P2 outside the casing 18, the operator can freely process the sample 4.

  The table moving device 16 can be configured by a linear conveyance mechanism having an arbitrary structure conventionally known. For example, the configuration is such that the feed screw shaft is rotated to translate the sample table 4 in the axial direction of the feed screw shaft, or the sample table 13 is fixed to the upper traveling portion of the conveyor belt that moves around and the straight line of the upper traveling portion. A configuration in which the sample table 13 is translated in accordance with the reciprocal movement can be employed. The power for moving the sample table 13 may be an automatic method using a power source such as a motor or may be manually moved.

  Next, a θ rotation driving device 21 is mechanically connected to both the X-ray generator 14 and the X-ray detector 15. This θ rotation drive device 21 rotates intermittently as shown by an arrow θ around the axis X1 (usually a horizontal axis) passing through the specimen 4 by synchronizing the X-ray generator 14 and the X-ray detector 15 with each other. Let In normal one-time measurement, rotation is performed from the position of θ = 0 ° shown in the figure to the position of θ = 360 ° (also the position shown in the drawing) around the axis X1.

  The θ rotation drive device 21 can be configured as follows, for example. That is, the X-ray generator 14 can be independently rotated about the axis X1 by a rotation drive system using a motor (for example, a pulse motor or a servomotor) capable of controlling the rotation angle as a drive source, and the rotation angle can be controlled. The X-ray detector 15 is independently rotated about the axis X1 by another rotational drive system using another motor as a drive source, and the X-ray generator 14 and the X-ray detector 15 are synchronized with each other. A driving method of controlling by a control circuit so as to rotate θ can be adopted.

  Further, the θ rotation drive device 21 can support the X-ray generator 14 and the X-ray detector 15 with a common support member and then mechanically connect the support member. In this case, the X-ray generator 14 and the X-ray detector 15 are commonly supported by the support member, so that they are always mechanically synchronized.

  Next, the control unit 2 in FIG. 1 provides a CPU (Central Processing Unit) 23 that functions as an arithmetic control unit, a ROM (Read Only Memory) 24 that stores basic system data, and a temporary work area. A random access memory (RAM) 25 and a memory 26 as a storage medium. The memory 26 includes a first file 27a, a second file 27b, and a third file 27c. The memory 26 can be formed by a mechanical memory such as a hard disk or a semiconductor memory. Further, the memory 26 may be formed by a single storage medium or may be configured by a plurality of storage media. Further, in the present embodiment, the calculation control is performed by one CPU 23. However, the functions may be shared by a plurality of CPUs, and the CPUs may be connected by wireless or wired signal lines. it can.

  A system management program 30 and an X-ray measurement program 31 are stored in the first file 27a. An image calculation program 36 and a database program 32 are stored in the second file 27b. Furthermore, a file area 33 for storing measurement raw data, a file area 37 for storing image data, and reconstruction data Is set. The third file 27c stores an IC tag management program 38 and further has an area 35 for storing IC tag data.

  The system management program 30 is a program that controls the X-ray measurement program 31, the database program 32, and the image calculation program 36. The X-ray measurement program 31 is a program for controlling the operation of the X-ray measurement unit 5 in FIG. The database program 32 is a program for realizing processing for managing various data. The image calculation program 36 is a program for generating an image signal for displaying data stored in various data files as an image on the screen of the display 3. The IC tag management program 38 is a program for managing data stored in the chip 6, that is, IC tag data.

  The image calculation program 36 includes a two-dimensional image processing unit that generates an image signal for displaying various data on the screen as a two-dimensional image (that is, a plane image), and various data on the screen. A three-dimensional image processing unit which is a part that generates an image signal to be displayed as a three-dimensional image (that is, a stereoscopic image displayed two-dimensionally). The two-dimensional image data and the three-dimensional image data generated by the image calculation program 36 are stored in the image data file 37, read out as necessary, and transmitted to the VRAM 12. In the present embodiment, two-dimensional image data and three-dimensional image data are generated and displayed. However, any other format of image data may be generated and displayed. For example, moving image data may be generated and displayed.

  Next, a chip 6 attached to, for example, subcutaneously, the mouse 4 as a specimen in FIG. 2 is an electronic component known as a so-called microchip or IC tag chip. This chip 6 has a small cylindrical shape in appearance as shown in FIG. The chip 4 is formed by covering the data receiving unit 40, the data transmitting unit 41, the power source unit 42, and the IC circuit 43 with a covering member 44 formed of an appropriate material, for example, glass, particularly biocompatible glass. .

  As shown in FIG. 3B, the IC circuit 43 includes a control unit 45 and a memory 46 as a data storage unit. The data receiving unit 40 and the data transmitting unit 41 are configured by an antenna printed on a circuit board, for example. The power supply unit 42 is formed by, for example, an electromagnetic induction type or radio wave type circuit. According to the electromagnetic induction method, the power supply unit 42 includes, for example, an antenna that generates a magnetic field in response to an external signal and a coil that extracts electric power from the generated magnetic field. If the radio wave system is adopted, the power supply unit 42 is configured by, for example, an antenna that receives external radio waves and a conversion unit that converts energy of the received radio waves into electric power.

  The control unit 45 is operated by the power supplied from the power supply unit 42, processes the signal received by the data reception unit 40, generates a signal to be transmitted to the outside, and transmits the signal to the data transmission unit 41. . In addition, the control unit 45 stores the signal received by the data receiving unit 40 and the signal processed by itself in the memory 46 as necessary.

  The memory 46 stores data according to an arbitrary method. In the present embodiment, for example, as shown in FIG. 3C, a signal is stored by multi-bit binary data, that is, data represented by storing “0” or “1” in a multi-bit storage area. It shall be. In the present embodiment, the specimen identification data is stored using the first 8 bits, and subsequently, a plurality of data are stored using the necessary number of bits. For example, as shown in FIG. 4A, following the specimen identification data, “sex”, “weight”, “birth date”, “gene information”, “measurement date”, “measurement condition”, “medication” It is assumed that “date and time”, “medication name”, “medication amount” and the like are stored.

  Next, the reader / writer 7 in FIG. 1 is installed at a position where a signal can be transmitted to and received from the chip 6 in the sample 4 when the sample table 13 moves between the measurement position P1 and the retracted position P2 in FIG. Is done. In the present embodiment, the reader / writer 7 is provided substantially at the center between the measurement position P1 and the retracted position P2. The reader / writer 7 is a device for reading and writing data to and from the chip 6 wirelessly. For example, the reader / writer 7 includes a data transmission unit configured by an antenna, a data reception unit configured by an antenna, It has a power signal transmission unit that transmits a power signal or a power wave to the power source unit 42 (see FIG. 3B), and a control unit that controls transmission and reception processing.

(Inspection method)
Hereinafter, the operation of the X-ray measurement apparatus having the above-described configuration will be described. Before that, the entire inspection method will be briefly described. The operator prepares a plurality of, for example, 150 mice to be inspected. Then, while keeping them divided into several groups, experiments with different conditions are carried out in groups. For example, 150 bodies are divided into 15 groups of 10 bodies, and one group is not dosed, and the other 14 groups are dosed with different drugs. In addition, only certain groups are operated on. In addition, healthy mice are initially introduced into one group, and mice with some illness from the beginning are introduced into another group.

  Then, one mouse is taken out from each group at an appropriate time and placed on the specimen table 13 shown in FIG. 2 of the X-ray measuring unit 5 shown in FIG. 1 to perform X-ray measurement (ie, X-ray fluoroscopy). In practice, an X-ray image is created for each mouse, the image data is stored in a storage medium, and the image data is displayed on a display when necessary to observe changes in the body of the mouse. When performing an operation on the specimen 4, the specimen stage 13 of FIG. 2 is placed at the retracted position P2 outside the casing 18, and the surgery is performed with the specimen 4 placed on the specimen stage 13. Is desirable.

  The X-ray measurement unit in FIG. 2 irradiates the specimen 4 with X-rays spreading in a conical shape from the X-ray source F, and detects the X-rays transmitted through the specimen 4 in a plane by the two-dimensional CCD X-ray detector 15. Therefore, the measurement time for one specimen 4 can be very short. For example, it is possible to perform measurement for one specimen 4 in a short time of about 17 seconds. For this reason, even if the total number of specimens 4 is large, X-ray images can be easily created for all of them.

  Further, as will be described later, the X-ray measurement apparatus 1 shown in FIG. 1 can store data corresponding to each specimen 4 in a storage area unique to the specimen 4 very accurately. Further, even when a plurality of measurements are repeated at different days, data of different dates obtained by the plurality of measurements can be stored accurately and continuously in the storage area corresponding to each specimen 4. . Furthermore, a plurality of stored measurement data can be freely recalled and displayed on the screen of the display 3 as desired by the operator. Therefore, if the X-ray measuring apparatus of this embodiment is used, each of a plurality of mice can be accurately selected and individually observed over a long period of time, so that highly reliable data can be obtained.

(Work process by operator)
Next, the work performed by the operator will be specifically described with reference to the process diagram shown in FIG. The operator inputs sample identification data, which is data for identifying a sample, to each of the plurality of chips 6 shown in FIG. 3A (step P1). Of course, the specimen identification data corresponding to individual specimens are different data that can be distinguished from each other. Data input in this case may be performed using the reader / writer 7 attached to the X-ray measurement unit 5 shown in FIG. 2, or may be performed using another portable reader / writer. Next, the operator inserts the chip 6 into the body of each specimen 4 using a predetermined insertion instrument (step P1).

  Instead of inserting the sample identification data into the chip 6 and inserting the chip 6 into the sample 4, the sample identification data is transmitted to the chip 6 by wireless communication after the chip 6 is inserted into the sample 4. You can also enter it. Also, information such as whether the sample 4 is healthy from the beginning or whether the sample 4 has any disease from the beginning can be input into the chip 6.

  Next, the operator raises the plurality of specimens 4 into which the chips 6 are inserted in a breeding box or a breeding house (process P2). Next, the operator performs an experiment on a specific specimen 4 as necessary. For example, the sample 4 is administered. When the experiment is performed, the experiment date, the experiment conditions, etc. are stored in the chip in the sample using the portable reader / writer or the reader / writer in the X-ray measuring apparatus (step P3).

  Next, when it becomes necessary to perform X-ray measurement on a specific specimen 4, that is, when it becomes necessary to create an X-ray image, specimen identification data in the specimen 4 is obtained using a portable reader / writer. The desired sample 4 is searched from the plurality of samples 4 by reading (step P4). In recent years, a reader / writer that can simultaneously read a plurality of chips 6 mounted on a plurality of specimens 4 has also been provided. Next, the found specimen 4 is placed on the specimen stage 13 (at the retracted position) of the X-ray measuring apparatus (process P5). Next, the operator inputs the sample identification data of the sample 4 placed on the sample table 13 from the input device 8 of FIG. 1 such as a keyboard (step P6).

  When the sample identification data input by the operator and the sample identification data in the sample 4 on the sample table 13 do not match, a predetermined warning is given by sound display, visual display, or the like. As a result, it is possible to prevent erroneous data for another sample 4 from being accumulated for a certain sample 4 (process P7). Next, CT measurement conditions (for example, tube voltage, tube current, used filter name, etc.) are input by the input device 8, and further an instruction to start CT measurement is given (step P8). The tube voltage and the tube current are condition data indicating the intensity of the X-ray irradiated to the specimen 4.

  When the CT measurement is finished, an X-ray image is displayed two-dimensionally or three-dimensionally on the screen of the display 3 in FIG. At the same time, the measurement date and measurement conditions are also displayed (process P9). Next, when the operator wants to view not only the current measurement data but also the previous data of the same sample and the data of related items of other samples, an instruction to that effect is given via a keyboard or the like. At that time, a search keyword is also input as search key data (process P10). Then, the instructed images are displayed one after another on the display screen. The operator can compare and observe these displays.

(Control flow)
Next, processing performed by the control unit 2 in FIG. 1 will be described with reference to flowcharts in FIGS. When the control is started, in step S1, it is checked whether or not there is the sample 4 on the sample table 13 placed at the retracted position P2 in FIG. If there is the sample 4, the process proceeds to step S2, and the sample identification data stored in the chip 6 in the sample 4 is read by the reader / writer 7 of FIG.

  Next, in the tape S3, it is checked whether or not the sample identification data input by the operator in step P6 in FIG. 5 matches the sample identification data in the chip 6. If they do not match, a warning is given in step S4 that the sample 4 on the sample table 13 is not the sample desired to be measured. This is a process for preventing the measurement of the wrong specimen 4 from being performed. For the warning, screen display, sound, lamp display, or any other means can be used.

  If the sample identification data input by the operator matches the sample identification data of the sample 4 on the sample table 13, in step S5, whether or not the sample identification data has already been registered, that is, the memory of FIG. It is checked whether or not the sample identification data is already stored in 26. If not registered, a new file is formed and the specimen identification data is stored therein (step S6). On the other hand, if registered, the process proceeds to step S7, and the corresponding data is read from the memory 26.

  Next, in step S8, the CPU refers to the time stored in the control unit 2 and stores the measurement date and time. In this case, the measurement date and time is stored in association with the specimen identification data as shown in FIGS. Next, the process proceeds to step S9, where it is checked in step P8 in FIG. 5 whether or not the operator has instructed the start of CT measurement. If the start has been instructed, the process proceeds to step S10. In step S10, it is checked whether the operator has input measurement conditions in step 8 of FIG. The measurement conditions are set conditions such as tube voltage V, tube current A, X-ray filter L, etc., as shown in the data format in FIG. Measurement temperature and measurement humidity can also be considered as measurement conditions.

  If YES is determined in steps S9 and S10, the CPU reads measurement conditions input by the operator in step S11. In this case, the measurement conditions are stored in association with the specimen identification data as shown in FIGS. Next, in step S12, the CPU operates the table moving device 16 of FIG. 2 to translate the sample table 13 from the retracted position P2 to the measuring position P1. When the sample stage 13 is placed at the measurement position P1, X-ray CT measurement is executed in step S13.

  Specifically, in FIG. 2, the θ rotation driving device 21 is operated and the angle θ with respect to the specimen 4 of the X-ray optical axis X0 passing through the centers of the X-ray source F and the X-ray detector 15 is θ = From the state of 0 °, it is rotated intermittently in an angle range of θ = 360 ° (that is, one rotation). That is, the X-ray source F and the X-ray detector 15 are synchronized with each other and intermittently rotated from θ = 0 ° to 360 ° around the specimen axis X1. The rotation step angle in this case is an appropriate angle α ° (α is appropriately determined according to the type of measurement). As a result, the X-ray source F and the X-ray detector 15 repeat rotation and stop at a step interval of α ° while θ rotates once from 0 ° to 360 °.

  Then, when the X-ray source F and the X-ray detector 15 are stopped a predetermined number of times corresponding to α °, the intensity of the X-ray emitted from the X-ray source F and transmitted through the specimen 4 is the X-ray detector. 15 is detected. Thus, the X-ray intensity distribution in the plane cross section of the specimen 4 is detected by the X-ray detector 15. In this specification, the data of the X-ray intensity distribution in such a plane cross section is represented by I (x, y). The X-ray detector 15 stops n times while the rotation angle θ of the optical system rotates from θ = 0 ° to θ = 360 °, and I (x, y) is measured each time. In this specification, X-ray intensity distribution data when the rotation angle changes as θ = 0 °, α × 1 °, α × 2 °,..., Α × (n−1) °, α × n °. Are respectively θ0 o'clock I (x, y), θ1 o'clock I (x, y), θ2 o'clock I (x, y), θ3 o'clock I (x, y),..., Θ (n−1). It will be called time I (x, y) and θn time I (x, y).

  While the measurement of the X-ray intensity distribution as described above is being performed, the CPU operates the image calculation program of FIG. 1 in step S14 to measure measurement conditions (for example, tube voltage, tube Current, X-ray filter name) is displayed as an image. The operator can confirm the conditions of the CT measurement currently performed by viewing this image display. Further, data obtained by measurement and not edited (so-called raw data) is a corresponding sample identification data area in the RAM 25 as shown in FIG. 4B in step S15. It is memorized continuously. As described above, the measurement date and time and the measurement conditions are stored in advance in this area.

  When the X-ray imaging of the specimen 4 is completed n times by the X-ray source F and the X-ray detector 15 (YES in step S16), the end of imaging is displayed on the screen of the display 3 in FIG. 1 in step S17. Is called. In step S18, the CPU stores the measurement date and time and measurement conditions (that is, measurement related data) in the memory 46 of the chip 6 in the sample 4 by the reader / writer 7 of FIG. In this case, these data are stored in association with the specimen identification data in a predetermined area of the data string in FIG.

  Next, the CPU proceeds to step S19 to activate the database program of FIG. 1 and execute the reconstruction calculation process. This reconstruction is to calculate the X-ray intensity at each coordinate point on the three-dimensional coordinate assumed inside the specimen 4 by integrating the n pieces of X-ray intensity distribution data obtained by the CT measurement in step S13. It is the process which is obtained by. In this specification, the reconstruction data, which is the three-dimensional X-ray intensity data, is represented by I (x0, y0, z0), I (x0, y0, z1), I (x0, y0, z2),. I (xn, yn, z (n-1)) and I (xn, yn, zn).

  In this specification, both n raw data obtained as a result of X-ray measurement and reconstruction data obtained by editing the raw data are measured from the meaning of data obtained as a result of X-ray measurement. This is called result data. Since the measurement result data is the raw data obtained as a result of the measurement and the data obtained by adding some edits to it, there are various kinds of measurement result data other than the raw data and the reconstructed data. You can also think about it. For example, data obtained by performing an averaging process on raw data, data after removing unnecessary data from raw data, and the like can be considered as measurement result data.

  In the present specification, the measurement-related data is used in the meaning of data that can specify the measurement result data in any way. Therefore, the measurement date / time data and the measurement condition data are measurement related data. Measurement conditions include, for example, tube voltage, tube current, X-ray filter name, type of X-ray source used, type of X-ray detector used, step width of θ rotation, time taken for measurement, etc. Various items are conceivable.

  When the reconstruction calculation process ends in step S19 in FIG. 7, the CPU stores the calculation result in the RAM 24 in FIG. 1 in step S20. At this time, as shown in FIG. 4C, the CPU stores the reconstructed data in association with the specimen identification data. In this area, the measurement date and time and the measurement conditions are stored in advance.

  Next, in step S21, the CPU creates 2D image data based on the reconstructed data by starting the image calculation program 36 of FIG. 1, and further creates 3D image data. In the two-dimensional image data, the X-ray intensity distribution in the cut surface when the specimen 4 is cut at an arbitrary virtual plane is represented by I (x0, y0, z0), I (x0, y0, z1), I (x0). , Y0, z2),..., I (xn, yn, z (n-1)), I (xn, yn, zn).

  The three-dimensional image data includes I (x0, y0, z0), I (x0, y0, z1), I (x0, y0, z2), ..., I (xn, yn, z (n-1). )), An X-ray intensity distribution in a three-dimensional space is virtually calculated based on I (xn, yn, zn), and the three-dimensional X-ray intensity distribution is expressed as a three-dimensional figure in a plane. is there. Since this three-dimensional image data is generated based on I (x0, y0, z0), ..., I (xn, yn, zn), the three-dimensional image calculation unit in the image calculation program 36 is The three-dimensional figure can be displayed with the viewpoint position for viewing the three-dimensional figure freely changed. That is, it is possible to display an image in which a three-dimensional figure rotates around an arbitrary axis.

  In step S21, the image calculation program 36 in FIG. 1 calculates an image including the specimen identification data and measurement conditions corresponding to the reconstruction data, and accordingly, the measurement result is displayed on the screen of the display 3. Sample identification data and measurement conditions are also displayed together with the 2D image and 3D image. Therefore, the operator can easily and clearly know the sample and measurement conditions corresponding to the measurement result displayed on the screen.

  When the image data is generated as described above, the CPU transmits the image data to the VRAM 12 in FIG. 1 in step S22, and displays the measurement result on the screen of the display 3 as a desired two-dimensional image or three-dimensional image. To do. In step S23, the CPU stores the image data in a predetermined storage area in association with the specimen identification data, the measurement date and time, and the measurement conditions as shown in FIG.

  FIG. 9 shows an example of image display. In this figure, the portion corresponding to the tail of the mouse in the reconstruction data (ie, X-ray image data) of the mouse as the specimen is displayed as an image. In the figure, a guide screen 50 and a perspective screen 51 are displayed on a screen 3a of the display 3 (see FIG. 1). In the illustrated example, image data of the tail portion of the mouse is displayed on the fluoroscopic screen 51 as a two-dimensional image (that is, a planar image). Note that a three-dimensional image (that is, a stereoscopic image) or a moving image may be displayed instead of the two-dimensional image. These various images may be displayed on the screen at the same time.

  The guide screen 50 provides various information related to the screen and X-ray measurement to the operator. In this embodiment, two windows, an image processing window and an information display window, are displayed in the guide screen 50. In the image processing window, two items of “brightness adjustment” and “contrast adjustment” are displayed as image correction items. If the operator indicates a desired item, the corresponding item can be adjusted. In the image processing window, two items of “distance measurement” and “area measurement” are displayed as selection items for image measurement. If the operator indicates a desired item, the corresponding item can be measured.

  “Image information” and “IC tag information” are displayed in the information display window. In the image information display, a tube voltage, a tube current, and an enlargement ratio are displayed. The tube voltage and the tube current are a value of the tube voltage and a value of the tube current when the data displayed on the fluoroscopic screen 51 is measured. The enlargement ratio is the enlargement ratio of the screen displayed on the fluoroscopic screen 51. Of course, the image calculation program of FIG. 1 can be configured to display other appropriate conditions as necessary. The operator can immediately recognize the conditions when the currently displayed X-ray image is taken by looking at the guide screen 50.

  Next, in addition to the X-ray image obtained by the current measurement, the operator may want to see previous data of the same individual or related data of another individual. In that case, the operator inputs that fact via the input device 8 of FIG. When the CPU confirms the input instruction in step S24 of FIG. 8 (YES in step S24), the CPU activates the database program 32 of FIG. 1 in step S25 and inputs the keyword (for example, specimen identification data, measurement date and time). The reconstruction data file 34 is searched based on the measurement conditions), and the reconstruction data corresponding to the keyword is read out.

  In step S26, the CPU generates an image signal by the image calculation program 36 based on the data read as described above, and the X corresponding to the data is displayed on the screen of the display 3 based on the image signal. Display line images. Thus, the operator can easily call and view other data related to the current measurement on the screen, and can make an accurate determination.

  When displaying other related data on the screen, if a lot of other related data is read and displayed suddenly side by side or superimposed on the screen, the operator's accurate judgment is lost. There is a fear. Therefore, when a lot of related data is read out, first, a large number of the read out data is displayed as a list on the screen, and the operator selects some data to be viewed from the list display. It is desirable to display the selected data as an image on the screen.

  Thereafter, when all the processes related to one specimen 4 are completed (YES in step S27), the CPU transfers the data stored in the RAM 24 of FIG. 1 to a predetermined area in the memory 26 (step S28), and performs control. Exit. The operator can call various data stored in the memory 26 when he / she wants and can confirm it by screen display.

(Other embodiments)
The present invention has been described with reference to the preferred embodiments. However, the present invention is not limited to the embodiments, and various modifications can be made within the scope of the invention described in the claims.
For example, although the above embodiment applies the present invention to an X-ray CT apparatus, the present invention can also be applied to apparatuses other than the X-ray CT apparatus, such as an X-ray apparatus, an X-ray bone density measuring apparatus, and the like. In the above embodiment, a mouse is considered as a specimen. However, in the present invention, an animal other than a mouse or a substance other than an animal can be used as a specimen.

  In the above embodiment, the present invention is applied to an X-ray measurement apparatus that moves the sample table 13 between the retracted position P2 and the measurement position P1 in FIG. The present invention can also be applied to an X-ray measurement apparatus having a structure placed at a measurement position. Further, the internal structure of the chip 6 is not limited to the configuration shown in FIGS. 3 (a), (b), and (c).

  In the embodiment shown in FIG. 2, a two-dimensional CCD sensor that is a two-dimensional X-ray detector is used as the X-ray detector 15. However, the X-ray detector 15 is an X-ray detector having any other configuration. Can be used. For example, a two-dimensional X-ray detector other than a two-dimensional CCD sensor, a zero-dimensional X-ray detector that receives X-rays in a dotted region, a one-dimensional X-ray detector that receives X-rays in a linear region, etc. An X-ray detector can also be used. As the two-dimensional X-ray detector other than the two-dimensional CCD sensor, for example, a flat plate X-ray detector formed by forming a planar X-ray light receiving surface with a stimulable phosphor or a two-dimensional flat panel is used. be able to. Examples of the zero-dimensional X-ray detector include PC (Proportional Counter) and SC (Scintillation Counter). One-dimensional X-ray detectors include, for example, PSPC (Position Sensitive Proportional Counter). When a one-dimensional X-ray detector is used as the X-ray detector, in order to detect X-rays in a plane, the one-dimensional X-ray detector is scanned parallel to the direction perpendicular to the arrangement direction of the detection elements, It is possible to scan to draw an arc in a direction perpendicular to the arrangement direction.

  In the above embodiment, in FIG. 2, when the X-ray source F and the X-ray detector 15 are rotated once from 0 ° to 360 ° and measurement is performed, they are rotated and stopped at a step interval of α °. , X-rays were detected (that is, sampled) at points of individual angular positions. However, the sampling method is not limited to this method, and a method may be employed in which the X-ray source F and the X-ray detector 15 are rotated continuously and only sampling is performed intermittently.

It is a block diagram which shows one Embodiment of the X-ray measuring apparatus which concerns on this invention. It is a perspective view which shows the X-ray CT measurement part which is the principal part of the X-ray measurement apparatus of FIG. 1A is a perspective view, FIG. 1B is a circuit diagram, and FIG. 1C is a memory structure. It is a figure which shows typically the memory | storage form of the data memorize | stored in the memory | storage part in the control part used with the apparatus of FIG. It is process drawing which shows an example of the operation | work performed by an operator. It is a flowchart which shows the flow of control implemented by the control part in the apparatus shown in FIG. It is a flowchart which shows the control flow following the control flow of FIG. It is a flowchart which shows the control flow following the control flow of FIG. It is a figure which shows an example of a screen display.

Explanation of symbols

1. 1. X-ray CT apparatus (X-ray measuring apparatus) 2. control unit; display,
4). Specimen (mouse); X-ray measurement unit, 6. Chip, 7. Reader / writer,
8). Input device, 9. Bus, 13. Sample table, 14. X-ray generator,
15. X-ray detector, 18. Casing, 19. Opening, 26. memory,
27a, 27b, 27c. File, 44. Covering member,
46. 50. Memory (data storage unit) 51. Guide screen Perspective screen,
P1. Measurement position, P2. Retraction position, R0. Incident X-ray, R1. Transmitted X-ray,
X0. X-ray optical axis, X1. Specimen axis

Claims (12)

(A) X-ray measurement means for irradiating a specimen placed at a measurement position with X-rays generated from an X-ray source and detecting X-rays transmitted through the specimen by an X-ray detection means;
(B) a chip that is fixed to the specimen and stores information about the specimen;
(C) a reader / writer that transmits and receives signals to and from the chip;
(A) The chip includes a data storage unit, a data reception unit, a data transmission unit, and a power supply unit that generates power based on an external signal,
(B) The data storage unit has an area for storing specimen identification data and a data writing area in which data can be written.
(C) The reader / writer
(A) a data receiving unit for receiving a signal output from a data transmitting unit in the chip;
(A) a data transmission unit that transmits a signal to a data reception unit in the chip;
(C) a power signal transmission unit that transmits a signal toward the power supply unit in the chip, and
(D) storage means for storing data;
(E) Measurement result data obtained by measurement using the X-ray measurement means and measurement related data corresponding to the measurement result data are stored in the storage means in association with the specimen identification data, and the chip An X-ray measuring apparatus comprising: control means for performing a process of writing the measurement related data in a data writing area. The X-ray measurement apparatus according to claim 1,
The X-ray measurement means is a means for varying the X-ray incident angle with respect to the specimen and measuring the intensity distribution of X-rays transmitted through the specimen for each X-ray incidence angle.
The measurement result data is X-ray intensity distribution data obtained by the X-ray detection means for each X-ray incident angle, or reconstruction data obtained by integrating individual X-ray intensity distribution data. An X-ray measuring apparatus characterized by that. The X-ray measuring apparatus according to claim 1 or 2,
The measurement related data is measurement date / time data of measurement or measurement condition data related to measurement, and the measurement condition data is at least one of irradiation X-ray intensity data and use filter name data. Line measuring device. In the X-ray measuring device according to any one of claims 1 to 3,
Image calculation means for generating an image signal based on an output signal of the X-ray detection means;
Image display means for displaying an image based on the image signal,
The X-ray measurement apparatus, wherein the image calculation means generates an image signal based on both the measurement result data and measurement-related data belonging to the same sample identification data as the sample identification data corresponding to the measurement result data . In the X-ray measuring device according to any one of claims 1 to 3,
Image calculation means for generating an image signal based on an output signal of the X-ray detection means;
Image display means for displaying an image based on the image signal;
Image data storage means for storing the image signal generated by the image calculation means in association with search key data;
Image display control means for selecting one or more image signals based on the search key data from the image signals stored in the image data storage means, and transmitting the selected image signals to the image display means;
An X-ray measuring apparatus comprising:   6. The X-ray measurement apparatus according to claim 5, wherein the search key data is the specimen identification data or measurement-related data. In the X-ray measuring device according to any one of claims 1 to 6,
An X-ray measurement apparatus, further comprising: a sample table that supports the sample; and a sample table moving unit that moves the sample table between the measurement position and a retracted position that is away from the measurement position. The X-ray measurement apparatus according to claim 7,
The reader receiving unit, the writer transmitting unit, and the power signal transmitting unit can exchange signals with the chip when the chip is at an arbitrary position between the retraction position and the measurement position. An X-ray measuring apparatus arranged at a position.   The X-ray measurement apparatus according to claim 1, wherein the specimen is an animal, and the chip is embedded under the specimen. The X-ray measurement apparatus according to claim 9, wherein
The data writing area in the data storage unit in the chip includes (1) an area for storing drug name data administered to the specimen, (2) an area for storing data on medication date and time for the specimen, (3 ) An area for storing dosage data for the specimen, (4) an area for storing data on the size of the lesion on the specimen, and (5) data on the date and time when the size of the lesion on the specimen is input. An X-ray measuring apparatus, further comprising: A specimen inspection method using the X-ray measurement apparatus according to claim 9 or 10,
The chip is continuously attached to each of a plurality of specimens,
Select a specific sample according to the sample identification data stored in the chip,
Perform measurement using the X-ray measurement means several times over the selected specimen, and obtain measurement result data in each measurement.
A specimen inspection method characterized by observing these measurement result data and observing temporal changes of the specimen. The specimen testing method according to claim 11, wherein
Subject the selected specimen to multiple treatments over time,
A specimen inspection method characterized by performing measurement using the X-ray measuring means after those processes and obtaining measurement result data in each measurement.

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