JP2007215546A5 - - Google Patents

Info

Publication number

JP2007215546A5

JP2007215546A5 JP2007076890A JP2007076890A JP2007215546A5 JP 2007215546 A5 JP2007215546 A5 JP 2007215546A5 JP 2007076890 A JP2007076890 A JP 2007076890A JP 2007076890 A JP2007076890 A JP 2007076890A JP 2007215546 A5 JP2007215546 A5 JP 2007215546A5

Authority

JP

Japan

Prior art keywords

antibody

fusion protein

amino acid

uti

protein according

Prior art date

2007-03-23

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
• Global Dossier
• Discuss

• 108020001507 fusion proteins Proteins 0.000 claims 22
• 102000037865 fusion proteins Human genes 0.000 claims 22
• 125000003275 alpha amino acid group Chemical group 0.000 claims 15
• 230000002401 inhibitory effect Effects 0.000 claims 12
• 108091005804 Peptidases Proteins 0.000 claims 10
• 239000004365 Protease Substances 0.000 claims 9
• 102100037486 Reverse transcriptase/ribonuclease H Human genes 0.000 claims 9
• 210000004027 cell Anatomy 0.000 claims 7
• 239000003112 inhibitor Substances 0.000 claims 7
• 102000040430 polynucleotide Human genes 0.000 claims 7
• 108091033319 polynucleotide Proteins 0.000 claims 7
• 239000002157 polynucleotide Substances 0.000 claims 7
• 101000946889 Homo sapiens Monocyte differentiation antigen CD14 Proteins 0.000 claims 6
• 238000006467 substitution reaction Methods 0.000 claims 6
• 150000001413 amino acids Chemical class 0.000 claims 5
• 230000003110 anti-inflammatory effect Effects 0.000 claims 5
• 102220389089 c.33G>T Human genes 0.000 claims 5
• 239000012634 fragment Substances 0.000 claims 5
• 230000002757 inflammatory effect Effects 0.000 claims 5
• 102220228148 rs1064793325 Human genes 0.000 claims 5
• 102100035877 Monocyte differentiation antigen CD14 Human genes 0.000 claims 4
• 238000012217 deletion Methods 0.000 claims 4
• 230000037430 deletion Effects 0.000 claims 4
• 201000010099 disease Diseases 0.000 claims 4
• 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 4
• 239000002158 endotoxin Substances 0.000 claims 4
• 238000003780 insertion Methods 0.000 claims 4
• 230000037431 insertion Effects 0.000 claims 4
• 230000017306 interleukin-6 production Effects 0.000 claims 4
• 238000007792 addition Methods 0.000 claims 3
• 229920001184 polypeptide Polymers 0.000 claims 3
• 108090000765 processed proteins & peptides Proteins 0.000 claims 3
• 102000004196 processed proteins & peptides Human genes 0.000 claims 3
• 206010001052 Acute respiratory distress syndrome Diseases 0.000 claims 2
• 206010040047 Sepsis Diseases 0.000 claims 2
• 206010040070 Septic Shock Diseases 0.000 claims 2
• 201000000028 adult respiratory distress syndrome Diseases 0.000 claims 2
• 239000003814 drug Substances 0.000 claims 2
• 230000000694 effects Effects 0.000 claims 2
• 102000046699 human CD14 Human genes 0.000 claims 2
• 229940124597 therapeutic agent Drugs 0.000 claims 2
• 102000035195 Peptidases Human genes 0.000 claims 1
• 229940124158 Protease/peptidase inhibitor Drugs 0.000 claims 1
• 206010051379 Systemic Inflammatory Response Syndrome Diseases 0.000 claims 1
• 230000006229 amino acid addition Effects 0.000 claims 1
• 210000004899 c-terminal region Anatomy 0.000 claims 1
• 230000002849 elastaseinhibitory effect Effects 0.000 claims 1
• 230000004927 fusion Effects 0.000 claims 1
• 238000004519 manufacturing process Methods 0.000 claims 1
• 239000000137 peptide hydrolase inhibitor Substances 0.000 claims 1
• 230000003449 preventive effect Effects 0.000 claims 1
• 230000000069 prophylactic effect Effects 0.000 claims 1
• 102000004169 proteins and genes Human genes 0.000 claims 1
• 108090000623 proteins and genes Proteins 0.000 claims 1
• 102200025791 rs179363876 Human genes 0.000 claims 1
• 102220234443 rs398123324 Human genes 0.000 claims 1
• 230000036303 septic shock Effects 0.000 claims 1
• 230000006433 tumor necrosis factor production Effects 0.000 claims 1