JP2007210985A - Disintegrable tablet and method for producing the same - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To provide a quickly disintegrable tablet which comprises a powder compression molded product having a high strength but having a low density and is excellent in a disintegration property in liquids. <P>SOLUTION: This disintegrable tablet is obtained by compressing a powder mixture comprising the powder of a raw material and a polymer binder which is solid at ordinary temperature and has a melting point of ≤100°C, and has a porosity of 20 to 40 vol.%. This disintegrable tablet is preferably obtained by compressing the mixture, while giving ultrasonic wave oscillations. The powder of the raw material as the main agent preferably has a weight-average particle diameter of 20 to 300 μm and a coefficient of variation of ≤50%. The method for producing the disintegrable tablet comprises filling a mold for table molding with the powder mixture, and then giving a compression force to at least one of molding pestles oppositely disposed on both the sides of the powder mixture, while giving ultrasonic wave oscillations to the powder mixture. <P>COPYRIGHT: (C)2007,JPO&INPIT

Description

  The present invention relates to a disintegrating tablet and a method for producing the same.

  Various powder compression-molded products such as intraoral rapidly disintegrating tablets, detergent tablets, and bath salt tablets are known. When a powder mixture containing 5 to 80% by weight of a thermoplastic material having a particle size of 5 to 500 μm is placed on the bottom of a pressurizing chamber and pressurized with a piston as a conventional technique related to a powder compression molding, ultrasonic waves are applied from one direction. A method of applying force has been proposed (Patent Document 1). The conditions for applying the ultrasonic force are that the frequency is 10 to 100 kHz, the amplitude is 20 to 60 μm, and the irradiation time is 0.5 to 3 seconds. The powder compression molding obtained in this way is used as cosmetics such as blushers and eye shadows. The powder compression molding obtained by this method is said to be friable and hard. However, since the pressure applied to the powder mixture during application of ultrasonic force is as high as 40 to 200 bar, that is, 4 to 20 MPa, this powder compression molding has a high degree of compression and a small gap between particles. Moreover, it cannot be said that disintegration is sufficient due to the high degree of compression.

JP-A-5-70325 method

  Accordingly, an object of the present invention is to provide a tablet having a high strength and a quick disintegration, which is made of a powder compression molding.

The present invention provides a disintegrating tablet obtained by compressing a mixture containing a raw material powder and a polymer binder that is solid at room temperature and has a melting point of 100 ° C. or less, and has a porosity of 20 to 40% by volume. The above-mentioned purpose is achieved. The porosity is expressed by the following formula.
Porosity (%) = (true density−tablet density) / true density × 100

  The present invention also includes a raw material powder and a mixture containing a polymer binder that is solid at room temperature and has a melting point of 100 ° C. or less in a mold for tablet molding, and are arranged opposite to each other with the mixture in between. The present invention provides a method for producing a disintegrating tablet in which compression is applied while applying ultrasonic vibration from the phase direction to the mixture using a molding wrinkle.

  According to the present invention, it is possible to obtain a rapidly disintegrating tablet made of a powder compression molded product having a low density despite its high strength and excellent in disintegration into a liquid.

  Hereinafter, the present invention will be described based on preferred embodiments thereof. The disintegrating tablet of the present invention comprises a powder compression molding. The tablet of the present invention is characterized by high strength and high disintegration into liquid. The liquid mentioned in this specification includes various liquids other than an aqueous liquid such as an aqueous liquid such as pure water and an organic solvent such as alcohol. The aqueous liquid widely includes pure water, various aqueous solutions, aqueous suspensions, body fluids, and the like. In order to improve the disintegration property when using powder compression moldings, simply set the molding pressure low to obtain a low density molding, but molding is caused by compression at low pressure. The strength of the object will decrease. As a result, defects such as cracks, chipping, and abrasion are likely to occur in the molded product during the manufacturing process of the product or during the transportation of the product. On the other hand, if the strength of the molded product is increased, the density of the molded product increases and the disintegration during use decreases. Thus, the strength of the conventional molded product and the disintegration property during use were in a trade-off relationship. On the other hand, according to the present invention, there is provided a compression-molded product having high strength and being rapidly disintegrating when used.

  The tablet of the present invention contains raw material powder and a polymer binder as its constituent materials. The raw material powder is the main ingredient in the tablet, and as the material, one or more kinds of appropriate substances are appropriately selected according to the specific use of the tablet. Similarly, regarding the particle size of the raw material powder, an appropriate size is appropriately selected according to the specific use of the tablet. Generally speaking, the raw material powder as the main agent has a weight average particle diameter of 20 to 300 μm and a coefficient of variation of 50% or less, and sufficiently satisfactory results are obtained.

  On the other hand, as the polymer binder, one that is solid at room temperature (= 35 ° C.) and has a melting point of 100 ° C. or less (DSC method) is used. The polymer binder serves as an excipient for binding the raw material powder particles to retain the tablet. The polymer binder is soluble in the liquid. Specifically, the polymer binder is water-soluble or oil-soluble. When the polymer binder is water-soluble or oil-soluble, when the tablet and water or oil come into contact with each other, the polymer binder binding the particles dissolves in them, and the bonds between the particles are released. The tablet will collapse. That is, the polymer binder also has a role as a disintegrant. The melting point by the DSC method is measured at a heating rate of 5 ° C./min.

  The reason why the melting point of the polymer binder is set to 100 ° C. or less is to reduce the energy applied when the tablet is molded. As will be described later with reference to the tablet production method, in the present invention, the raw material powder particles are bonded together by melting the polymer binder by frictional heat generated by ultrasonic vibration. Therefore, when the melting point of the polymer binder is high, it is necessary to apply a larger ultrasonic vibration or longer ultrasonic irradiation, which is disadvantageous in terms of energy. Further, when the melting point is high, the whole raw material powder becomes high temperature, and the raw material powder may be thermally damaged. Therefore, in the present invention, a polymer binder having a melting point of 100 ° C. or lower is used. In the present invention, two or more kinds of polymer binders may be used. In that case, the melting point of at least one kind of polymer binder may be 100 ° C. or less. In particular, among the two or more polymer binders, the polymer binder having the highest melting point preferably has a melting point of 100 ° C. or lower.

  The lower limit of the melting point of the polymer binder is not particularly limited, but the polymer is solid at least at room temperature (= 35 ° C.). That is, the melting point of the polymer binder does not fall below normal temperature. When the melting point of the polymer binder is close to room temperature, the tablet may feel sticky. Therefore, the melting point is preferably 40 ° C or higher, particularly 45 ° C or higher. On the other hand, generally, the melting point of the raw material powder is higher than that of the polymer binder. If the melting point of the raw material powder is preferably 30 ° C. or higher, more preferably 40 ° C. or higher, higher than the melting point of the polymer binder, adverse effects due to melting of the raw material powder can be avoided.

  The blending ratio of the raw material powder and the polymer binder in the tablet is preferably 0.01 to 33, particularly 0.01 to 19 in terms of the weight ratio of the raw material powder / polymer binder. Although the weight of the raw material powder as the main ingredient depends on the specific use of the tablet, it is preferably 1 to 97% by weight, particularly 1 to 95% by weight, based on the tablet. On the other hand, the weight of the polymer binder as the excipient is preferably 3 to 99% by weight, particularly 5 to 99% by weight, based on the tablet. Appropriate values are selected for the blending amounts of the raw material powder and the polymer binder depending on the specific use of the tablet. For example, when used as a bath agent, the weight of the raw material powder is preferably 50 to 95% by weight, particularly 70 to 90% by weight, based on the tablet. On the other hand, the weight of the polymer binder is preferably 5 to 50% by weight, particularly 10 to 30% by weight, based on the tablet. Moreover, when using as a pharmaceutical tablet or a mouth freshener, it is preferable that the weight of a raw material powder is 1 to 97 weight% with respect to a tablet, especially 10 to 90 weight%. On the other hand, the weight of the polymer binder is preferably 3 to 99% by weight, particularly 10 to 90% by weight, based on the tablet. In addition to the raw material powder and the polymer binder, the tablet may contain other components as necessary. A variety of such components can be selected depending on the specific use of the tablet. For example, when using a tablet as a bath agent, a fragrance | flavor and a pigment | dye can be mix | blended.

  The tablet of the present invention is characterized by having a large number of fine voids. Specifically, the tablet of the present invention has many fine voids having a porosity of 20 to 40% by volume, preferably 25 to 40% by volume, and more preferably 25 to 35% by volume. A powder compression molding having high strength while having such a high porosity cannot be obtained by conventional techniques. In this invention, a tablet becomes a low density because the porosity of a tablet shall be 20 volume% or more. As a result, when the tablet comes into contact with a liquid such as water or oil, the liquid easily enters the gap and quickly disintegrates. From this point of view, the higher the porosity, the better. However, since an excessively high porosity may cause a decrease in strength, the upper limit of the porosity is set to 40% by volume in the present invention. A method for measuring the porosity will be described in Examples described later.

  Although the tablet of the present invention has many fine voids, the raw material powder is firmly bonded by melting of the polymer binder by frictional heat. Has almost the same strength. As an example, for a bath preparation with a weight of 45 g and a tablet thickness of about 10 to 16 mm, a hardness of 6 kg or more is required when a point inside 5 mm from the side of the tablet is measured in the thickness direction of the tablet using a Kiyama hardness tester. This includes tablet production processes such as tableting processes, ejection from tableting machines, transportation processes from pillow packaging machines, pillow packaging processes, picking / boxing processes, and transportation from factories to stores. It is a hardness that does not cause cracks, chipping, abrasion, etc. in normal handling such as handling at home and purchaser's home. Of course, damage under special circumstances such as dropping is excluded. The tablet according to the present invention sufficiently satisfies this hardness, and when it is produced with the same level of hardness as a powder compression molded product by a conventionally known high-pressure press, the dissolution rate is greatly improved due to the high porosity. The Details are given in the examples.

  Similarly, in the mouth freshener, when the hardness is measured in the diameter direction of the tablet, 1.5 kg or more is required. The reason why the value is smaller than that of the bath preparation is that the weight is 0.4 g and the tablet thickness is as thin as 2.7 mm. When the tablet according to the present invention is used as a mouth freshener, this hardness is sufficiently satisfied.

  As for other applications, the tablet of the present invention produced by the mechanism in which the polymer binder is melted by frictional heat and the raw material powder is firmly bonded has the strength of the conventional powder compression molding while having a high porosity. It can be said that it has the same level of strength.

The tablet of the present invention is used for various applications, and is molded into a size corresponding to each application. The size of the tablet area 7～8000Mm ² approximately in a plan view, in particular 20～3000Mm ² about about height 1 to 30 mm, and particularly about 2 to 20 mm. There is no restriction | limiting in particular in the shape of a tablet, For example, it can shape | mold into well-known shapes, such as columnar shapes, polygonal column shapes, such as a triangular column shape and a quadratic column shape.

  The tablet of the present invention can be used, for example, as a bath agent. When a tablet is put into a bathtub, the tablet dissolves in a short time, so there is an advantage that the waiting time for bathing is shortened. When used as a bath agent, it is preferable to use a carbonate and an organic acid as a raw material powder and polyethylene glycol (hereinafter referred to as PEG) as a polymer binder. As the carbonate, sodium carbonate, sodium hydrogen carbonate, magnesium carbonate, potassium carbonate and the like are used. As the organic acid, it is preferable to use a water-soluble and solid acid such as succinic acid, fumaric acid, malic acid, adipic acid, tartaric acid, benzoic acid, citric acid, pyrrolidone carboxylic acid and salicylic acid. PEG having a molecular weight of 1000 to 20000 is preferably used.

  Moreover, the tablet of this invention can also be used as an intraoral quick disintegrating tablet. Intraoral rapidly disintegrating tablets are used as various pharmaceuticals and mouth fresheners, and dissolve in a short time with saliva in the mouth. Therefore, it is preferably used for elderly people and those with a reduced swallowing function. Moreover, even if it is a healthy person, it is useful when water cannot be prepared such as when moving. When the tablet of the present invention is used as an intraoral rapidly disintegrating tablet, it quickly dissolves when the tablet is contained in the mouth.

  The tablet of the present invention can also be used as a tablet detergent. When the tablet is put into the washing tub, it dissolves in a short time, so that it is difficult for the detergent to remain undissolved. In addition, the detergent concentration quickly increases, so that the cleaning property is improved and the washing time is shortened.

  A tablet having a porosity in the above range is preferably produced by the method described below. FIG. 1 shows a schematic diagram of a preferred apparatus used to produce the tablet of the present invention. The apparatus 10 includes a frame body 11. A tableting table 12 is attached in the horizontal direction at the center of the frame 11 in the height direction. A through hole is provided in the center of the tableting table 12, and a tablet molding die 13 is fitted in the through hole. The mold 13 has a cylindrical shape whose upper and lower sides are open. The mold 13 has a flange 13a projecting laterally at the top. The flange 13a is bolted (not shown) to the tableting table 12.

  Ultrasonic vibration elements 14 a and 14 b are disposed at positions above and below the cavity of the mold 13. Each element 14a, 14b is supported by air cylinders 15a, 15b. The upper air cylinder 15a is attached to the top plate 11a of the frame 11 and hangs from it. On the other hand, the lower air cylinder 15 b is mounted on the bottom plate 11 b of the frame body 11. Thereby, each ultrasonic vibration element 14a, 14b can be moved in the vertical direction. Note that the moving means of the ultrasonic vibration element is not limited to the air cylinder, and other devices such as a hydraulic cylinder and a ball screw press using an electric motor may be used.

  Horns 16a and 16b are attached to the tips of the ultrasonic vibration elements 14a and 14b. The tips of the horns 16 a and 16 b have the same shape as the cavity of the molding die 13. These three are located on the same axis. Each of the horns 16a and 16b has a role of applying ultrasonic vibration to the mixture and a role of a molding cage for compressing the mixture when the mixture containing the raw material powder and the polymer binder is compression-molded. is doing. Therefore, in the following description, these horns will be referred to as an upper rod 16a and a lower rod 16b, respectively. The tip shape of each of the flanges 16 a and 16 b is the same shape as the cavity of the mold 13.

  A tablet manufacturing method using the device 10 having the above structure will be described with reference to FIGS. 2A to 2C. First, as shown in FIG. 2A, the lower air cylinder 15b is operated, The lower brace inserted in advance in the mold is lowered in the mold in order to fill the raw material powder. Further, the upper air cylinder 15a is operated, and the upper punch 16a is raised and retracted in the space on the tableting table 12. As a result, the mold 13 is formed with a recess defined by the cavity and the lower collar 16b. This recess is filled with a mixture (hereinafter referred to as a powder mixture) 20 containing raw material powder and a polymer binder.

  The powder mixture 20 includes a raw material powder, a polymer binder, and various components to be blended as necessary, and these components are uniformly mixed. Alternatively, the powder mixture 20 may be obtained by coating the main component in the raw material powder or other powder raw material with a polymer binder using a rolling granulation method or the like. Rolling granulation is a granulation method in which a raw material powder is granulated by spraying a binder while applying rotation in a stirring tank such as a Henschel mixer or a high speed mixer. In the powder mixture 20 obtained by rolling granulation, the raw material powder particles are coated with a polymer binder. By using the powder mixture 20 in such a state, a low-density and high-strength tablet can be successfully produced (the reason will be described later).

  Next, the lower ultrasonic vibrating element 14b is operated to vibrate the lower eyelid 16b ultrasonically. At the same time or before and after this, the upper ultrasonic vibration element 14a is operated to ultrasonically vibrate the upper eyelid 16a. Then, the air cylinder 15a is operated to lower the upper rod 16a in a state of ultrasonic vibration, and the upper rod 16 is inserted into the concave portion filled with the powder mixture 20. As a result, the powder mixture 20 is compression molded as shown in FIG.

  This manufacturing method is characterized in that compression molding is performed while applying ultrasonic vibration by the upper and lower ridges 16a and 16b arranged opposite to each other with the powder mixture 20 in between. The particles of the powder mixture 20 are vibrated by receiving ultrasonic waves, thereby generating frictional heat. The frictional heat melts the polymer binder to bond the particles together. By applying ultrasonic waves from above and below with the powder mixture 20 interposed therebetween, the vibration of the particles is promoted, and the bonding of the powder via the polymer binder is strengthened. This makes it possible to increase the strength of the compression molding to the same extent even if the compression pressure is lowered, compared to the conventional method in which compression molding is performed while applying ultrasonic vibration only by one of the scissors. become. As a result, a compression molded product having a low density and a high strength can be easily obtained. The vibration conditions of each of the flanges 16a and 16b may be the same or different, but generally the same conditions are set.

  In particular, when the powder mixture 20 is in a state in which the particles of the raw material powder are coated with a polymer binder, for example, obtained by rolling granulation as described above, the frictional heat generated by the vibration of the particles is efficient. Thus, the particles are transmitted to the polymer binder, and the bonding of the particles through the polymer binder is further ensured.

  In the present manufacturing method in which ultrasonic vibration is applied by the upper and lower ridges 16a and 16b, when manufacturing a tablet for a bath agent or a rapidly disintegrating tablet in the oral cavity, the compression pressure by these ridges 16a and 16b is preferably The low pressure can be set to 0.1 to 2.5 MPa, more preferably 0.1 to 0.5 MPa. On the other hand, in the conventional method in which the compression molding is performed while applying ultrasonic vibration only by one of the scissors, the compression molding is performed at a pressure higher by one digit or more than the present manufacturing method.

  The ability to set the compression pressure to a low value is advantageous in that physical damage is reduced with respect to the raw material powder as the main agent. For example, even when a liquid component is contained in the raw material powder, the compression pressure is low, so that the powder particles are broken and the liquid component in the particles oozes out, resulting in a quality problem. Therefore, no trouble in manufacturing is caused.

  The conditions of ultrasonic vibration applied to the powder mixture 20 can be appropriately adjusted according to the components of the powder mixture 20, the amount of the mixture, the specific use of the target tablet, and the like. When the tablet is used as, for example, a bath preparation or a rapidly disintegrating tablet in the oral cavity, the ultrasonic frequency is preferably 10 to 100 kHz, particularly preferably 15 to 30 kHz. By setting the frequency within this range, the degree of attenuation of the ultrasonic wave in the powder mixture 20 as a medium is reduced, and vibration is transmitted to the deep part of the powder mixture 20.

  When the tablet is used as, for example, a bath preparation or a rapidly disintegrating tablet in the oral cavity, the amplitude of the ultrasonic wave is preferably 5 to 100 μm, particularly preferably 10 to 50 μm. By setting the amplitude within this range, the vibration of the particles becomes sufficiently large, and sufficient frictional heat is generated due to this. As a result, molding in a short time becomes possible.

  As a result of the examination by the present inventors, it was found that a short time of ultrasonic irradiation is sufficient. The reason for this is that ultrasonic vibration is applied from above and below across the powder mixture 20. The irradiation time is preferably 0.1 to 5 seconds, more preferably 0.2 to 2.0 seconds. Although it depends on the melting point and blending amount of the polymer binder and the weight and thickness of the raw material powder, if it is irradiated for too long, the surface will become high temperature, the raw material will deteriorate, and the polymer will melt and solidify, resulting in excessive hardness (hard to dissolve) ), Increased adhesion to wrinkles, and color burn may occur.

  When the compression molding is completed, the ultrasonic vibration is stopped, the upper air cylinder 15a is operated as shown in FIG. 2 (c), and the upper punch 16a is lifted and retracted in the space on the tableting table 12. Further, the lower air cylinder 15b is operated and the lower rod 16b is also raised. As a result, the target tablet 21 is taken out of the cavity of the mold 13.

  The tablets thus obtained are used as intraoral rapidly disintegrating tablets, detergent tablets, bath preparation tablets and the like as described above. In addition to this, it can be suitably used as cosmetics, agricultural chemicals and the like by taking advantage of being fast disintegrating.

  As mentioned above, although this invention was demonstrated based on the preferable embodiment, this invention is not restrict | limited to the said embodiment. For example, in the manufacturing method described above, for the purpose of preventing the powder mixture from adhering to the soot, an anti-adhesion inclusion such as a Teflon (registered trademark) sheet may be interposed therebetween.

  Hereinafter, the present invention will be described in more detail with reference to examples. However, the scope of the present invention is not limited to such examples. Unless otherwise specified, “%” means “% by weight”.

[Examples 1 and 2]
A bath preparation tablet was produced by the method shown in FIG. 2 using the apparatus shown in FIG. As the ultrasonic vibration elements 14a and 14b in the apparatus 10, Langevin elements (oscillation frequency 19 kHz, maximum output 1200 W, maximum amplitude 30 μm) manufactured by Seidensha Electronics Co., Ltd. were used. First, the following components were prepared. Fumaric acid, the main raw material, was tumbled and granulated using a Henschel mixer and coated with PEG. This and other raw material powders were mixed well to obtain a powder mixture.
・ Fumaric acid 40%
(Raw material powder, weight average particle size 172 μm, coefficient of variation 49.6%)
・ 44% sodium bicarbonate
(Raw material powder, weight average particle size 99 μm, coefficient of variation 41.2%)
・ Sodium carbonate 10%
(Raw material powder, weight average particle size 92 μm, coefficient of variation 45.1%)
・ PEG
(Polymer binder, weight average molecular weight 8500, melting point 60-66 ° C.) 5.49%
・ Perfume 0.5%
・ Dye 0.01%

  The apparatus shown in FIG. 1 was put into the state shown in FIG. 2A, and 45 g of the powder mixture was filled in the concave portion of the mold. The diameter of the recess was 60 mm. Next, the lower arm was vibrated ultrasonically. Also, the upper eyelid was ultrasonically vibrated and lowered to be inserted into the recess to obtain the state shown in FIG. Thus, compression molding was performed. The molding conditions are as shown in Table 1 below. After the compression molding is completed, the ultrasonic vibration is stopped, the upper eyelid is raised and retracted, and the lower eyelid is also raised, and the target tablet is taken out from the mold as shown in FIG. .

[Comparative Example 1]
The tablet was obtained by compression molding according to the procedure shown in FIG. First, as shown in FIG. 3A, the molding die 103 was set on the lower punch 106b. The mold 103 has a cylindrical shape with an open top and bottom, and its inner diameter was 60 mm. A powder mixture 20 having the same composition as in Example 1 and obtained by rolling granulation in the same manner as in Example 1 was filled in the recesses of the mold 103 as shown in FIG. . The filling amount was 45 g. Next, as shown in FIG. 3 (c), the mold 103 was set in a hydraulic press machine 107 (TYPE CD-50-135B manufactured by Riken Kikai Co., Ltd.) and attached to the hydraulic cylinder 105 of the press machine 107. A hydraulic press was performed with the upper arm 106a. After pressing, the lower rod 106b was removed, and the mold 103 and the upper rod 106a were turned upside down as shown in FIG. Further, the mold 103 was pushed down, and the tablet was taken out from the mold.

[Evaluation]
The porosity, hardness and dissolution time of the tablets obtained in Examples and Comparative Examples were measured by the following methods. The results are shown in Table 1 below.

[Porosity]
The true density of the powder mixture is measured using Accupic 1330 (trade name) which is a true density meter manufactured by Micromeritex. The density of the tablet is calculated from its volume and weight. Using these values, the porosity is calculated from the following equation. The true density of the powder mixture was 1.8889 g / cm ³ .
Porosity (%) = (true density−tablet density) / true density × 100

〔hardness〕
Using a Kiyama-type hardness meter, the hardness is measured at three positions 5 mm inside from the outer periphery of the tablet, and the average value of these values is calculated.

[Dissolution time]
Place 41 ° C hot water in a 5 liter beaker and let it stand, and put the tablet in it. The dissolution state of the tablet is visually observed, and the time from when the tablet is inserted until the tablet fragment is about 2 mm or less is measured.

  As is apparent from the results shown in Table 1, it can be seen that the tablet of Example 1 has almost the same hardness as the tablet of Comparative Example 1, but the porosity is considerably higher than that of the tablet of Comparative Example 1. As a result, it can be seen that the tablet of Example 1 has a shorter dissolution time than the tablet of Comparative Example 1. In particular, the dissolution time of Example 2 is further shortened because the porosity is higher than that of Example 1. The hardness of Example 2 is lower than that of Example 1, but the hardness of Example 2 is a value that causes no problem in handling as described above.

Example 3
In this example, a cool tablet in the mouth was produced. The following components were used as raw materials and mixed thoroughly to obtain a powder mixture. Using the obtained powder mixture, tablets were obtained in the same manner as in Example 1. However, the inner diameter of the mold was 13 mm. The filling amount of the powder mixture was 0.4 g. The molding conditions are as shown in Table 2.
・ Erythritol 40%
(Raw material powder, weight average particle size 40 μm, coefficient of variation 33.1%)
Maltitol 42%
(Raw material powder, weight average particle size 142 μm, coefficient of variation 49.7%)
・ Sugar ester (polymer binder, melting point 55 ° C.) 5%
・ Corn starch 10%
-Fragrance 12%
・ Fragrance 2 1%

[Comparative Example 2]
Using a powder mixture having the same composition as in Example 3, a tablet was obtained by hydraulic press in the same manner as in Comparative Example 1.

[Evaluation]
About the tablet obtained in Example 3 and Comparative Example 2, the porosity and hardness were measured by the above-mentioned method, and the dissolution time was measured by the following method. The hardness was measured as the fracture limit strength when a disk-shaped tablet was pressed in the radial direction. The true density of the powder mixture was 1.4995 g / cm ³ . The results are shown in Table 2 below.

[Dissolution time]
Put the tablet in your mouth and roll it on your tongue to dissolve. Be careful not to bite with your teeth. Measure the time from when the tablet is in the mouth until it is completely dissolved. The measurement is performed twice and the average value is obtained.

  As is apparent from the results shown in Table 2, it can be seen that the tablet of Example 3 has a higher porosity than the tablet of Comparative Example 2 although the hardness of the tablet of Comparative Example 2 is slightly higher than that of the tablet of Comparative Example 2. As a result, it can be seen that the tablet of Example 3 has a shorter dissolution time than the tablet of Comparative Example 2.

It is a schematic diagram which shows the preferable apparatus used in order to manufacture the tablet of this invention. It is a figure which shows the manufacturing process of the tablet using the apparatus shown in FIG. It is a figure which shows the manufacturing process of the tablet of the comparative example using a hydraulic press machine.

Explanation of symbols

DESCRIPTION OF SYMBOLS 10 Tablet manufacturing apparatus 12 Tableting table 13 Mold 14a, 14b Ultrasonic vibration element 15a, 15b Air cylinder 16a, 16b Molding bowl 20 Powder mixture 21 Tablet

Claims (5)

  A disintegrating tablet obtained by compressing a mixture containing a raw material powder and a polymer binder that is solid at room temperature and has a melting point of 100 ° C. or lower, and has a porosity of 20 to 40% by volume.   A mixture containing a raw material powder and a polymer binder that is solid at room temperature and has a melting point of 100 ° C. or less is filled in a tablet molding die, and molding molds arranged opposite to each other with the mixture interposed therebetween. A method for producing a disintegrating tablet, wherein compression is applied to the mixture while applying ultrasonic vibration from a phase direction.   The production method according to claim 2, wherein the compression is performed with a press pressure of 0.1 to 2.5 MPa.   The manufacturing method according to claim 2 or 3, wherein ultrasonic vibration is applied at a frequency of 10 to 100 kHz, an amplitude of 5 to 100 µm, and an irradiation time of 0.1 to 5 seconds. The production method according to any one of claims 2 to 4, wherein the mixture is one in which particles of the raw material powder are coated with the polymer binder.

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