JP2007202625A - Liquid preparation device - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To provide a liquid preparation device by which automatic liquid preparation can be carried out more precisely. <P>SOLUTION: An aqueous drug preparation device 10 has an accommodating container accommodating medication vials, ejecting units arranged for every drug vial. The accommodating container turns sealed with its opening portion closed by the lid body being a part of the ejecting units by relatively moving to the ejecting unit. The ejecting units guide aqueous medicine in the drug vials the medication vials by communicating the medication vials to the medication vials after reducing the pressure inside of the accommodating container keeping closed. The aqueous medicine is automatically prepared by repeating the movement of the accommodating container and the ejection of the aqueous medicine in series. <P>COPYRIGHT: (C)2007,JPO&INPIT

Description

  The present invention relates to a liquid blending device that blends a liquid by supplying a specified amount of liquid from a plurality of storage containers to the blending container.

  Conventionally, in various fields, liquid preparation has been performed in which a plurality of different liquids are prepared at a fixed ratio. For example, in the pharmaceutical field, a plurality of types of liquid medicine are prepared according to a prescription. Conventionally, such preparation has been performed by measuring each liquid medicine manually using a graduated cylinder or the like. However, such manual weighing is not only complicated, but also has a problem that a mixing error is likely to occur.

  Therefore, a liquid preparation apparatus that automatically prepares liquid such as liquid medicine has been proposed. For example, Patent Document 1 discloses a liquid medicine automatic dispensing machine that automates the preparation of liquid medicine. In this liquid medicine automatic dispensing machine, a plurality of chemical containers and pumps installed in the chemical containers are installed on a rotary table. When preparing liquid medicine, move the nozzle of the specified chemical container onto the medicine bottle by driving the rotary table, and then drive the pump to discharge the specified amount of liquid medicine into the medicine bottle. Yes. According to this dispensing machine, the specified amount of the chemical solution is automatically discharged to the medicine bottle, so that the liquid medicine can be dispensed automatically.

JP 2003-325639 A

  However, in such a liquid medicine dispensing machine, the discharge amount of liquid medicine is managed by a pump separated from the prescription bottle. Therefore, it cannot be confirmed whether or not the liquid medicine has been reliably discharged into the prescription bottle. Further, it is necessary to provide a pump capable of strictly controlling the suction and discharge amount in each of the plurality of chemical containers. A pump capable of strictly controlling the suction and discharge amount tends to be expensive, and when a large number of such pumps are provided, the entire apparatus tends to be expensive. Further, when a large number of pumps are provided, there is a problem that the control becomes complicated.

  Therefore, an object of the present invention is to provide a liquid preparation apparatus that can perform automatic liquid preparation more accurately.

  The liquid preparation apparatus of the present invention is a liquid preparation apparatus that prepares a liquid by supplying a specified amount of liquid from a plurality of storage containers to the preparation container, and is a container that contains the preparation container and has an opening. A container is provided for each storage container, the opening of the storage container located at the discharge position set for each storage container is shielded to seal the interior of the storage container, and the internal pressure of the storage container is reduced. A discharge unit that guides the liquid in the storage container to the preparation container, and a transfer unit that moves the storage container and the discharge unit to a discharge position corresponding to the selected storage container by relatively moving the storage container and the discharge unit. It is characterized by.

  In a preferred embodiment, each discharge unit includes a lid that shields the opening of the storage container and forms a sealed space when the storage container is transferred to the discharge position.

  In another preferred aspect, the discharge unit controls the discharge liquid volume based on the amount of change in internal pressure of the storage container accompanying the discharge of the liquid. In this case, the discharge unit discharges liquid medicine by connecting the storage container and the storage container after decompressing the sealed storage container, and the amount of change in internal pressure accompanying liquid medicine discharge is a value corresponding to the target discharge liquid volume. It is desirable to end the liquid medicine discharge by blocking the communication between the storage container and the storage container. It is also desirable for the discharge unit to communicate or block the storage container and the storage container by opening and closing a valve provided in a discharge pipe connecting the storage container and the storage container. Furthermore, it is desirable that the discharge unit excludes the gas in the discharge pipe by introducing liquid medicine into the discharge pipe prior to liquid discharge.

  In another preferred aspect, the discharge unit is a single pump shared by a plurality of discharge units, and a pipe connecting the pump and the plurality of discharge units, and the pressure increase / decrease branched according to the number of discharge units And a pressure increasing / decreasing valve provided in each branch passage of the pressure increasing / decreasing pipe, and opening / closing the pressure increasing / decreasing valve switches the discharge unit connected to the pump.

  In another preferred aspect, the transfer means includes a vertical transfer means for transferring the storage container in the vertical direction, and the vertical transfer means includes a mounting table on which the storage container is mounted, and the mounting table from below. And a cam that is rotatable in a vertical plane, and the mounting table moves up and down as the cam rotates.

  In another preferred embodiment, the storage container is an adapter selected according to the size of the mixing container to be stored, and the difference in the size of the mixing container can be obtained by being interposed between the storage container and the mixing container. With an adapter to absorb.

  According to this invention, the inside of the storage container which accommodated the preparation container is made into the airtight state, and the liquid in a storage container is guide | induced to the preparation container by decompressing this sealed space. When the liquid medicine is discharged and the gas volume in the container changes, the internal pressure of the container changes. Therefore, it can be confirmed whether liquid medicine discharge was performed reliably by checking the internal pressure of a storage container. As a result, automatic liquid preparation can be made more accurate. Further, the closed container that is essential for the discharge of the liquid medicine and the discharge confirmation is formed by moving the storage container to the discharge position. In other words, a plurality of medicine bottles share one sealed container. Therefore, the configuration of the entire apparatus can be simplified.

  Embodiments of the present invention will be described below with reference to the drawings. FIG. 1 is a diagram showing a configuration of a liquid medicine preparation device 10 according to an embodiment of the present invention, and FIG. 2 is a schematic top view thereof. This liquid medicine preparation device 10 is an apparatus that automatically prepares a plurality of kinds of liquid medicines according to a user's instruction. The liquid medicine required for the preparation is stored in the medicine bottles 100a, 100b,... 100 * (hereinafter, subscripts a, b,..., * Are omitted) as storage containers. At this time, a specified amount of liquid medicine is discharged from the medicine bottle 100 to the prescription bottle 110 which is a preparation container.

  Each medicine bottle 100 is provided with a discharge unit 14 which will be described later. The discharge unit 14 and the medicine bottle 100 are arranged in a circular pattern on the rotary table 18 as shown in FIG. Note that FIG. 1 shows the circular array converted into a linear array for easy viewing. Below the turntable 18, a storage container 12 that stores the prescription bottle 110 and a vertical movement mechanism 16 that transports the storage container 12 in the vertical direction are provided. When preparing the liquid medicine, the rotary table 18 is rotated to move the tip of the discharge pipe 34 connected to the desired medicine bottle 100 above the prescription bottle 110. In this state, the prescription bottle 110 is moved upward together with the container 12, and the opening formed in the upper part of the container 12 is shielded by the lid 30 attached to the bottom surface of the rotary table 18. When the opening is shielded by the lid 30, the inside of the storage container 12 is hermetically sealed. Then, the liquid medicine in the medicine bottle 100 is guided to the prescription bottle 110 by reducing the pressure inside the sealed container 12. By repeating this operation with a plurality of liquid medicines necessary for liquid medicine preparation, automatic liquid medicine preparation is realized.

  Next, each part of the liquid medicine preparation device 10 will be described in detail. FIG. 3 is a detailed view of part A of FIG. As described above, the prescription bottle 110 is stored in the storage container 12. The container 12 is a substantially cylindrical container having a size that can accommodate the prescription bottle 110, and its upper part is completely open. A flange 13 extending outward is formed at the upper end of the storage container 12, and the interior of the storage container 12 is hermetically sealed by the flange 13 being in close contact with the lid 30 attached to the bottom surface of the rotary table 18. Is done. Needless to say, the shape and size of the container 12 are not particularly limited as long as the container 12 can accommodate the prescription bottle 110 and can be lifted and adhered to the lid 30 to form a sealed space. However, when the prescription bottle 110 is smaller than the container 12, the upper end of the prescription bottle 110 and the distal end of the discharge pipe 34 are separated from each other, and liquid medicine discharge may not be performed properly. In order to solve such a problem, an adapter may be provided that keeps the upper end height of the prescription bottle 110 in the container 12 substantially constant regardless of the size of the prescription bottle 110. FIG. 8B is a diagram illustrating an example of the adapter 60. When a prescription bottle 110 that is smaller than the container 12 as shown in FIG. 8B is used, an adapter 60 is interposed between the container 12 and the prescription bottle 110 so that the inside of the container 12 It is desirable to keep the upper end height of the prescription bottle 110 substantially constant. By providing such an adapter 60, either a case where a relatively large prescription bottle 110 is used (see FIG. 8A) or a case where a relatively small prescription bottle 110 is used (see FIG. 8B) is used. Even so, the upper end position of the prescription bottle 110 can be maintained at substantially the same height, and appropriate liquid medicine can be discharged.

  The container 12 is placed on a placement table 42 that is a part of the vertical movement mechanism 16. The mounting table 42 is inserted through a guide shaft 44 extending in the vertical direction, and can move only in the vertical direction along the guide shaft 44. Below the mounting table 42 is supported by an elliptical cam 46. The elliptical cam 46 is rotatable in a vertical plane, and the mounting table 42 moves up and down as the elliptical cam 46 rotates. The rotation of the elliptical cam 46 is controlled by the vertical movement mechanism drive unit 50. When the mounting table 42 is raised to the highest height, the flange portion 13 of the storage container 12 is in close contact with the lid 30 and the inside of the storage container 12 is hermetically sealed. The position where the sealing state is achieved becomes the discharge position. Further, when the mounting table 42 is lowered to the lowest descending height, the flange 13 of the storage container 12 is below the tip of a discharge pipe 34 to be described later. That is, the lowest descending height of the mounting table 42 is set to a height that does not cause physical interference when the discharge pipe 34 and the storage container 12 are relatively moved in the horizontal plane.

  In the present embodiment, a mechanism including an elliptical cam 46 is used as the vertical movement mechanism. However, any mechanism that can relatively move the receiving container 12 to a position where the opening is shielded by the lid 30 is used. Of course, other mechanisms may be used. For example, a vertical moving mechanism including a lead screw and a motor may be used. Further, instead of moving the container 12 in the vertical direction, a discharge unit 14 described later may be moved in the vertical direction.

  The discharge unit 14 is provided for each medicine bottle 100, and includes a lid 30 that shields the opening of the container 12, a discharge mechanism that guides liquid medicine in the medicine bottle 100 to the prescription bottle 110, and the inside of the container. A pressure increasing / decreasing mechanism for increasing / decreasing the pressure of the air layer is provided.

  The lid 30 is affixed to the bottom surface of the turntable 18 and has a size enough to completely cover the opening of the storage container 12. In addition, an O-ring 32 is provided on the bottom surface of the lid 30, that is, on the surface facing the storage container 12, to ensure adhesion with the flange 13 of the storage container 12. When the storage container 12 is raised to the highest height, the opening of the storage container 12 is completely covered with the lid 30 and the flange 13 and the O-ring 32 are in close contact with each other. As a result, the inside of the storage container 12 becomes a sealed space that is completely blocked from the outside world.

  A water sensor 40 for detecting the position of the liquid medicine in the discharge pipe 34 is further provided on the bottom surface of the lid 30. The water sensor 40 is an optical sensor that irradiates the discharge pipe 34 with light and detects the presence or absence of liquid in the discharge pipe 34 based on a transmission amount or the like at that time. The water sensor 40 is installed so that it can irradiate detection light to a reference position X set near the tip of the discharge pipe 34, and can detect the presence or absence of liquid medicine at the reference position X. The controller 56 detects the presence or absence of liquid medicine at the time when the detection result of liquid medicine at the reference position X is switched, that is, when the liquid medicine is present or not, or when the liquid medicine is absent. The time point when the state is switched to the state is processed as the time point when the top of the liquid medicine reaches the reference position X. The reason for providing the water sensor 40 is to eliminate the gas in the discharge pipe 34 prior to the liquid medicine discharge, which will be described in detail later.

  The discharge mechanism includes a discharge pipe 34 connecting the vicinity of the bottom of the medicine bottle 100 and the vicinity of the top of the prescription bottle 110, and a discharge valve 36 provided in the discharge pipe 34. The discharge pipe 34 is a pipe for guiding the liquid medicine stored in the medicine bottle 100 to the prescription bottle 110, and its proximal end is located near the bottom of the medicine bottle 100, that is, in the liquid medicine in the medicine bottle 100. is doing. Further, the distal end of the discharge pipe 34 penetrates the lid body 30 and projects downward from the lid body 30. In addition, in order to ensure the sealing property of the container 12, the penetration location where the discharge piping 34 penetrates the cover body 30 is given.

  The liquid medicine stored in the medicine bottle 100 is guided to the medicine bottle 110 through the discharge pipe 34. A discharge valve 36 that is controlled to be opened and closed by the control unit 56 is provided in the middle of the discharge pipe 34 in order to appropriately permit or block the flow of the liquid medicine. A desired amount of liquid medicine can be discharged by appropriately opening or closing the discharge valve 36 according to the internal pressure of the sealed container 12. The valve 36 is preferably a pinch valve. Thereby, cleaning may be performed only on the discharge pipe 34, and the maintenance work can be simplified. Further, the discharge pipe 34 can be easily replaced. The relationship between the internal pressure of the container 12 and the opening / closing timing of the discharge valve 36 will be described in detail later. Note that the inside of the medicine bottle 100 is always maintained at atmospheric pressure by an open air pipe that connects the vicinity of the top of the medicine bottle 100 and the outside.

  The pressure increasing / decreasing mechanism is provided in the pump 20 for increasing / decreasing the inside of the sealed container 12, the pressure increasing / decreasing pipe 22 connecting the pump 20 and the inside of the receiving container 12, and the pressure increasing / decreasing pipe 22. A pressure increasing / decreasing valve 25 is provided. As shown in FIG. 1, the present embodiment has a configuration in which a single pump 20 is connected to a single pressure increasing / decreasing pipe 22 branched according to the number of medicine bottles 100. The liquid medicine is discharged by changing the internal pressure of the container 12 with the pump 20. Various pumps 20 can be considered depending on the discharge amount control method. In this embodiment, a syringe pump capable of quantitatively controlling the gas suction and discharge volume is used. The pump drive unit 54 drives the pump 20 in response to an instruction from the control unit 56.

  Each branch path 24 branched from the pressure-increasing / decompressing pipe 22 penetrates the lid body 30 and projects downward from the lid body 30. Each branch path 24 is provided with a pressure increasing / decreasing valve 25 that is controlled to be opened / closed by the control unit 56. By opening / closing the pressure increasing / decreasing valve 25, the branch path 24 communicated with the pump 20, and thus, The discharge unit 14 that performs pressure increase / decrease of the storage container 12 is switched.

  The pressurizing / decompressing pipe 22 is further provided with a single pressure gauge 26 and an air release valve 28. The pressure gauge 26 is provided at a position closer to the pump than each pressure increasing / decreasing valve 25, and can measure the pressure inside the pressure increasing / decreasing pipe 22. The air release valve 28 is provided on a pipe that communicates the inside and outside of the pressurizing / depressurizing pipe 22, and is also provided at a position closer to the pump than each pressurizing / depressurizing valve 25. By opening the air release valve 28, the inside of the storage container 12 connected to the branch path 24 in which the pressure increasing / decreasing pipe 22 and the pressure increasing / decreasing valve 25 are opened can be returned to atmospheric pressure.

  The turntable 18 is a moving mechanism for horizontally moving the plurality of discharge units 14 with respect to the container 12. The rotation table 18 is controlled by a horizontal movement mechanism drive unit 52. A moving mechanism other than the rotary table may be used as long as the mechanism can horizontally move the plurality of discharge units 14 relative to the container 12. For example, instead of the rotary table, a vertical movement mechanism such as a belt conveyor or an XY table may be used. Further, a mechanism for horizontally moving the container 12 instead of horizontally moving the discharge unit 14 may be used.

  The control part 56 controls the liquid medicine preparation apparatus 10 whole. The control unit 56 stores in advance the discharge positions of various liquid medicines as device information. Moreover, the liquid medicine kind and liquid volume etc. which are required for the preparation input from the user at the time of liquid medicine preparation are temporarily stored as preparation information. And when liquid medicine preparation is performed, a drive sequence for the rotary table 18, the vertical movement mechanism 16, various valves 25, 28, 36, etc. is generated based on the preparation information and device information, and the generated drive sequence is generated. The command signal corresponding to is output to each drive unit 50, 52, 54.

  Next, the principle at the time of discharging a liquid medicine with this liquid medicine preparation apparatus 10 is demonstrated. In the present embodiment, in a state where the storage container 12 is sealed and sealed with the lid body 30, only the corresponding pressure increase / decrease valve 25 is opened and the pump 20 is driven to decompress the interior of the storage container 12. If the target amount can be reduced, then the discharge valve 36 is opened to allow the inside of the medicine bottle 100 and the inside of the container 12 to communicate with each other. When the discharge valve 36 is opened, the liquid medicine stored in the medicine bottle 100 is guided to the storage container 12 by the pressure difference. And the liquid medicine discharged from the discharge piping 34 is supplied to the prescription bottle 110 accommodated inside the container 12. At this time, the internal pressure change of the storage container 12 accompanying the discharge of the liquid medicine is monitored by the pressure gauge 26, and the internal pressure change amount of the storage container 12 from the start to the end of the discharge becomes the internal pressure change amount corresponding to the target discharge liquid volume. When it reaches, the discharge valve 36 is closed and the liquid medicine discharge is finished.

Here, the relationship between the target discharge liquid volume ΔVa and the internal pressure of the container 12 will be described. When the target discharge liquid volume ΔVa is discharged into the prescription bottle 110 stored in the storage container 12, the volume change amount of the gas inside the storage container 12 can be regarded as ΔVa. And the container 12 at the time of liquid medicine discharge start, the pressurization / decompression piping 22 including the branch path 24 connected to the container 12, and the gas volume in the cylinder of the syringe pump 20 (hereinafter referred to as “gas volume in the container”). ”) Is Vs, the gas volume in the container after the liquid medicine is discharged can be (Vs−ΔVa). Further, since it is considered that there is no significant temperature change from the start to the end of the liquid medicine discharge, the product (PV) of the gas volume (V) and pressure (P) in the container can be regarded as substantially constant. . Therefore, when the internal pressure of the storage container 12 at the start of discharge is Ps and the internal pressure of the storage container after discharging the liquid medicine of the target discharge liquid volume ΔVa is Pe, the following equation is established.
Vs · Ps = (Vs−ΔVa) · Pe Equation 1

In the present embodiment, the internal pressure Ps at the start of discharge is obtained by the pressure reducing operation of the syringe pump 20. When the internal pressure in the container before the pressure reduction is the atmospheric pressure P0 and the gas volume is V0, Equation 2 is established.
V0 · P0 = Vs · Ps Equation 2
Substituting Equation 2 into Equation 1 yields Equation 3 below.
V0 · P0 = (Vs−ΔVa) · Pe Equation 3
Here, when the internal pressure Pe of the storage container 12 at the end of discharge is P0 (atmospheric pressure), Equation 3 is
Vs = V0 + ΔVa Formula 4
It becomes. In other words, the target discharge liquid volume ΔVa can be discharged into the prescription bottle by setting the volume Vs after the pressure reduction to a value satisfying the equation 4 and setting the internal pressure before the pressure reduction and at the end of the liquid medicine discharge to the same atmospheric pressure P0. become. Here, as can be seen from Equation 4, the gas volume Vs after decompression is a value obtained by adding the target discharge liquid volume ΔVa to the gas volume V0 before decompression. Here, in this embodiment, a syringe pump is used as the pump 20. When the pressure is reduced by the syringe pump, the volume difference between the gas volume V0 before the pressure reduction and the gas volume Vs after the pressure reduction is the gas volume sucked by the syringe pump. That is, when the internal pressure before decompression and at the end of liquid medicine discharge is the same atmospheric pressure P0, the suction gas volume in the syringe pump 20 becomes the target discharge liquid volume.

  And according to this control method, since the suction volume in the syringe pump becomes the target discharge liquid volume, even if the gas volume in the container or the liquid volume in the prescription bottle is unknown, the discharge liquid can be easily obtained. You can control the product. Moreover, there is a merit that it is not necessary to consider the absolute value of the atmospheric pressure.

In this embodiment, the discharge liquid volume is controlled by the suction gas volume of the syringe pump. However, the discharge liquid volume may be controlled by the internal pressure of the storage container. In this case, a discharge start pressure Ps that satisfies Equation 1 is obtained in advance. The discharge start pressure Ps can be obtained by Expression 5 obtained by modifying Expression 1.
Ps = Pe (1−ΔVa / Vs) Equation 5
Then, after reducing the inside of the storage container 12 to the determined discharge start pressure Ps, the discharge valve 36 is opened, and the discharge valve 36 is closed when the internal pressure of the storage container 12 reaches the discharge stop pressure Pe. When the discharge is finished, the target discharge liquid volume ΔVa can be discharged. In this case, since it is not necessary to perform volume control by a pump, a relatively inexpensive pump such as a diaphragm pump can be used.

  In the present embodiment, when the internal pressure Pe at the time of stopping the discharge is set to a high value, before reaching the internal pressure Ps at the time of stopping the discharge, in other words, before the liquid medicine of a desired volume is discharged, The pressure in the storage container 12 becomes an equilibrium state, and the discharge of liquid medicine is stopped. Since the pressure value at which the pressure in the medicine bottle 100 and the pressure in the container 12 are balanced varies depending on the hydraulic head pressure ρgh, the internal pressure Pe when the discharge is stopped is set in consideration of the hydraulic head pressure ρgh. In addition, when making Pe into the atmospheric pressure P0, it is necessary to make the liquid level in the medicine bottle 100 always be higher than the outlet of the discharge pipe 34.

  FIG. 4 is a diagram showing a change in internal pressure of the storage container 12 when liquid medicine is discharged. In FIG. 4, the horizontal axis represents time, and the vertical axis represents the internal pressure of the container 12. A thin solid line L1 indicates a case where the liquid level of the stored liquid medicine in the medicine bottle 100 is low, and a thick solid line L2 indicates a case where the liquid level of the stored liquid medicine in the medicine bottle 100 is high.

  When the discharge valve 36 is opened with the pressure reduced to the discharge start pressure Ps, liquid medicine is discharged into the prescription bottle 110 through the discharge pipe 34. As the liquid medicine is discharged, the gas volume in the storage container 12 decreases and the internal pressure of the storage container 12 increases. When the pressures at the proximal end and the distal end of the discharge pipe 34 are equal, that is, when the internal pressures of the medicine bottle 100 and the storage container 12 are equal, the discharge of the liquid medicine is automatically stopped and the internal pressure of the storage container 12 is stopped. Converges to a constant value. The convergence value of the internal pressure is a value obtained by adding the head pressure ρgh to the atmospheric pressure P0. The head pressure ρgh varies according to the liquid level of the liquid medicine in the medicine bottle 100, and the higher the liquid level, the higher the head pressure ρgh.

  Next, the flow of liquid medicine preparation in this liquid medicine preparation apparatus 10 will be described. FIG. 5 is a flowchart showing the flow of liquid medicine preparation. When performing liquid medicine preparation, the user first inputs the liquid medicine type and liquid volume required for liquid medicine preparation to the control unit 56 as preparation information. The control unit 56 generates a drive sequence for each unit based on the input blending information and device information stored in advance (S10).

  If the drive sequence can be generated, the liquid medicine is prepared based on the obtained drive sequence. Specifically, first, all the valves are closed, and the rotary table 18 is driven so that the discharge pipe 34 corresponding to the liquid medicine to be discharged is positioned above the container 12 (S12). At this time, in order to prevent physical interference between the discharge pipe 34 and the storage container 12, the storage container 12 is lowered to the lowest lowered height.

  Subsequently, the vertical movement mechanism 16 is driven to raise the storage container 12 to the highest height, and the opening of the storage container 12 is shielded by the lid 30 attached to the bottom surface of the turntable 18 (S14). At this time, in order to improve the hermeticity of the storage container 12, it is desirable to perform a gas suction operation with the pump 20 after the storage container 12 and the lid 30 are in contact with each other. That is, if the container 12 and the lid 30 come into contact with each other due to the rising of the container 12, only the pressure-intensifying valve 25 corresponding to the liquid medicine to be discharged is opened, and the pump 20 is driven to suck. By the suction drive of the pump 20, the inside of the storage container 12 becomes a light negative pressure. And by the influence of this negative pressure, the adhesiveness of the collar part 13 and the cover body 30 of the storage container 12 improves, and the airtightness in the storage container 12 can be improved more. When the flange 13 of the storage container 12 and the lid 30 are in close contact with each other, the air release valve 28 is opened, and the interior of the storage container 12 is returned to atmospheric pressure. If the inside of the storage container 12 is returned to atmospheric pressure, the air release valve is closed, and the storage container 12 is closed again.

  Next, the gas existing inside the discharge pipe is discharged (S16). In order to exclude gas, first, the discharge valve 36 and the pressure increasing / decreasing valve 25 are opened to allow the medicine bottle 100 and the container 12 and the container 12 and the pump 20 to communicate with each other. In this state, the pump 20 is driven to suck the gas inside the container 12 at a low speed. With this gas suction, the internal pressure of the container 12 is reduced at a low speed, and the liquid medicine stored in the medicine bottle 100 moves at a low speed to the vicinity of the tip of the discharge pipe 34. At this time, the water sensor 40 provided on the bottom surface of the lid body 30 detects whether or not the liquid medicine has moved to the reference position X of the discharge pipe 34. If the water sensor 40 detects that the liquid medicine has moved to the reference position X, the control unit 56 immediately stops the driving of the pump 20. At the same time, the discharge valve 36 is closed to block communication between the medicine bottle 100 and the container 12. By stopping the driving of the pump 20, the movement of the liquid medicine in the discharge pipe 34 is also stopped. Since the decompression operation is stopped when the liquid medicine reaches the reference position X, the liquid medicine remains at the reference position X and is not discharged to the prescription bottle 110. On the other hand, the inside of the discharge pipe 34 is filled with liquid medicine, and the gas existing in the discharge pipe 34 is almost eliminated. If it will be in this state, the air release valve 28 will be opened again and the inside of the container 12 will be returned to atmospheric pressure.

  Here, the reason why the gas existing inside the discharge pipe 34 is excluded is as follows. As described above, in this embodiment, the gas discharge volume of the sealed space, that is, the storage container 12 and the pressurizing / decompressing pipe 22 is set as the target discharge liquid volume. And the discharge liquid volume is controlled by giving the internal pressure variation | change_quantity according to this gas volume variation | change_quantity. In other words, if the gas volume in the sealed space at the start of liquid medicine discharge is different from the initial schedule, an error occurs in the discharge liquid volume. In order to reduce this error, in this embodiment, the inside of the discharge pipe 34 is filled with liquid medicine in advance to eliminate excess gas. This gas exclusion process may be performed only when the medicine bottle 100 is discharged for the first time. That is, since the gas in the discharge pipe 34 is excluded after the second time, this gas exclusion process becomes unnecessary.

  If the gas in the discharge pipe 34 can be eliminated, the liquid medicine discharge process is started (S18). FIG. 6 is a flowchart showing a more detailed flow of this liquid medicine discharge process. When performing the liquid medicine discharge process, first, all the valves 25, 28, and 36 are closed, and the container 12 is sealed (S22). Thereafter, the pressure increasing / decreasing valve 25 is opened and the syringe pump 20 sucks the gas having the same volume as the target discharge liquid volume ΔVa to reduce the pressure inside the container 12 (S24, S26).

  Subsequently, the discharge valve 36 is opened (S30). When the discharge valve 36 is opened, the liquid medicine stored in the medicine bottle 100 is guided from the inside of the medicine bottle 100 to the inside of the container 12 through the discharge pipe 34. Then, the liquid medicine discharged from the tip of the discharge pipe 34 is supplied to the prescription bottle 110 housed in the container 12.

  As the liquid medicine is supplied, the gas volume in the container 12 decreases and the internal pressure increases. The change in internal pressure at this time is also monitored by the pressure gauge 26. When the internal pressure of the container 12 reaches the atmospheric pressure P0, the control unit 56 closes the discharge valve 36 and stops the discharge of liquid medicine (S32, S34). And the liquid medicine discharge process will be complete | finished if the atmospheric | air release valve 28 provided in the pressurization / decompression piping 22 is open | released and the internal pressure of the storage container 12 is returned to atmospheric pressure.

  FIG. 7 is a flowchart showing a flow in the case where a diaphragm pump or the like is used instead of the syringe pump and the discharge liquid volume is controlled based on a change in the internal pressure of the storage container. In this case, first, the discharge start pressure Ps is calculated based on the target discharge liquid volume ΔVa (S20). This can be determined by Equation 5. Subsequently, as in the case of using a syringe pump, after all the valves 25, 28, and 36 are closed, only the pressure increasing / decreasing valve 25 is opened (S22, S24). Then, the pump 20 (diaphragm pump) is driven to start depressurization inside the container 12 (S27). At the time of this pressure reduction, the control part 56 monitors the internal pressure of the storage container 12 (S29). When the internal pressure reaches the discharge start pressure Ps, the pressure reducing operation is stopped (S28). The subsequent processing is the same as when a syringe pump is used (after step S30 in FIG. 6).

  When the liquid medicine discharge process is completed, finally, when the vertical movement mechanism 16 is driven and the storage container 12 is lowered, the discharge of one kind of liquid medicine is completed (S42). If one type of liquid medicine discharge is completed, the control part 56 will judge whether the liquid medicine required for mixing still remains based on the calculated drive sequence (S44). When there is a liquid medicine necessary for the preparation, the rotary table 18 is driven to move the discharge pipe 34 corresponding to the liquid medicine to the upper side of the container 12 (S46). And step S14-step S44 are performed again. If this is repeated and all of the liquid medicine necessary for the preparation is discharged into the prescription bottle 110, the liquid medicine preparation is completed.

  As is apparent from the above description, according to the present embodiment, the volume of the discharge liquid is controlled by controlling the internal pressure of the sealed container, that is, the storage container 12. In addition, if a syringe pump or the like that can control the gas suction / discharge amount is used, the discharge liquid volume can be controlled without being affected by the volume of the storage container, the absolute value of the atmospheric pressure, or the like. Therefore, highly accurate automatic liquid preparation can be performed with a simpler configuration. In addition, one pump 20 and pressure gauge 26 are configured to be shared by a plurality of discharge units 14. Therefore, a liquid medicine preparation device can be provided at low cost. In addition, maintenance such as pump control and wiring can be simplified. Further, the sealed container necessary for controlling the discharge liquid volume is formed by moving the container 12 containing the prescription bottle 110 relative to the discharge unit. In other words, it can be said that a plurality of discharge units 14 share a single sealed container. Therefore, a simpler and more compact liquid medicine preparation device can be provided.

  In addition, although the liquid medicine preparation apparatus was demonstrated as one Example of this invention, as long as it is an apparatus which mixes multiple types of liquid, you may naturally apply to another apparatus. Further, other configurations may be different from those of the present embodiment as long as the liquid medicine can be sucked and discharged by at least pressurizing and depressurizing the air layer of the intermediate tank. The procedure for sucking and discharging liquid medicine may be changed as appropriate.

It is a figure which shows the structure of the liquid medicine preparation apparatus which is embodiment of this invention. It is a schematic top view of a liquid medicine preparation device. FIG. 2 is a detailed view of a part A in FIG. 1. It is a graph which shows the relationship between the discharge time of a liquid medicine, and the internal pressure of a storage container. It is a flowchart which shows the flow of liquid medicine preparation. It is a flowchart which shows the more detailed flow of a liquid medicine discharge process. It is a flowchart which shows the flow of the liquid medicine discharge process at the time of using a diaphragm pump. It is a figure which shows the position of the prescription bottle in a storage container, (A) shows the case where an adapter is not used, (B) shows the mode at the time of using an adapter.

Explanation of symbols

  DESCRIPTION OF SYMBOLS 10 Liquid medicine preparation device, 12 Container, 14 Discharge unit, 16 Vertical movement mechanism, 18 Rotary table, 20 Pump, 22 Pressure-reducing piping, 25 Pressure-reducing valve, 26 Pressure gauge, 28 Atmospheric release valve, 30 Lid 34 discharge pipe, 36 discharge valve, 56 control unit, 60 adapter, 100 medicine bottle, 110 prescription bottle.

Claims (9)

A liquid compounding apparatus for preparing a liquid by supplying a specified amount of liquid from a plurality of storage containers to the compounding container,
A container for storing a blending container, the container having an opening;
A storage container is provided for each storage container, shields the opening of the storage container located at the discharge position set for each storage container, seals the inside of the storage container, and reduces the internal pressure of the storage container. A discharge unit for guiding the liquid in the preparation container;
Transfer means for moving the storage container to the discharge position corresponding to the selected storage container by relatively moving the storage container and the discharge unit;
A liquid preparation apparatus comprising: The liquid preparation device according to claim 1,
Each discharge unit includes a lid that shields the opening of the storage container to form a sealed space when the storage container is transferred to the discharge position. The liquid preparation apparatus according to claim 1 or 2,
The discharge unit controls the volume of discharge liquid based on the amount of change in internal pressure of the storage container accompanying the discharge of liquid. The liquid preparation apparatus according to claim 3,
The discharge unit discharges liquid medicine by communicating the storage container and the storage container after reducing the pressure of the sealed storage container, and the amount of change in internal pressure accompanying liquid medicine discharge reaches a value corresponding to the target discharge liquid volume. A liquid preparation apparatus, wherein liquid medicine discharge is terminated by blocking communication between the storage container and the storage container. A liquid preparation device according to claim 3 or 4,
The discharge unit is configured to open or close a valve provided in a discharge pipe connecting the storage container and the storage container, thereby connecting or blocking the storage container and the storage container. A liquid preparation device according to any one of claims 3 to 5,
Prior to liquid discharge, the discharge unit guides liquid medicine into the discharge pipe to eliminate gas in the discharge pipe. The liquid preparation device according to any one of claims 1 to 6,
The discharge unit is
A single pump shared by multiple discharge units;
A pipe connecting a pump and a plurality of discharge units, and a pressure-intensifying pipe branched according to the number of discharge units;
A pressure increasing / decreasing valve provided in each branch of the pressure increasing / decreasing pipe;
The liquid blending apparatus is characterized in that the discharge unit communicated with the pump is switched by opening and closing the pressure increasing / decreasing valve. A liquid preparation apparatus according to any one of claims 1 to 7,
The transfer means comprises a vertical transfer means for transferring the container in the vertical direction,
The vertical transfer means includes
A mounting table on which the container is mounted;
A cam that supports the mounting table from below and is rotatable in a vertical plane;
And a mounting table is moved up and down with the rotation of the cam. A liquid preparation device according to any one of claims 1 to 8,
The storage container is an adapter selected according to the size of the mixing container to be stored, and includes an adapter that absorbs the difference in the size of the mixing container by being interposed between the storage container and the mixing container. A liquid blending device.

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