JP2007159804A - Mouth plug member for plastic bag - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To provide a mouth plug member for a plastic bag, provided with a flexible bag composed of a gas barrier film excellent in safety and a plastic tubular port for chemicals (transfusion) which are easy to oxidize like an amino acid drug, a glucose drug and a fat emulsion. <P>SOLUTION: In the mouth plug member for the plastic bag, provided with a flexible bag (A) composed of the gas barrier film and the plastic tubular port (2), a resin composition which is removable in the case of using and which has oxygen absorption ability and composed of at least a thermoplastic resin (resin A) and a thermoplastic resin (resin B) where C-H bond dissociation energy is small, is provided. <P>COPYRIGHT: (C)2007,JPO&INPIT

Description

  The present invention relates to a plug member applied to a plastic bag such as a chemical solution bag.

  A chemical solution (infusion solution) that easily oxidizes such as an amino acid preparation, a glucose preparation and a fat emulsion needs to use a container having gas barrier properties. Conventionally, glass products have been used as the gas barrier chemical solution container, but there are problems such as heavy and easy breakage.

  Therefore, recently, in order to improve this problem, a bag made of a plastic film has been developed. (1) Made of a plastic such as polyethylene (2) Made of a film in which a gas barrier property is imparted to a polyolefin-based resin (for example, see Patent Document 1) (3) Infusion bag made of a gas barrier film and a plastic tubular port A plug member provided with a gas barrier property to the plug member (for example, see Patent Document 2).

Prior art documents are shown below.
Japanese Patent Laid-Open No. 5-184463 Japanese Patent Laid-Open No. 11-128317

  However, the above-mentioned type (1) needs to be put in an exterior having a gas barrier property because the gas permeability of the film itself is good.

  For the type (2), the infusion bag itself has suppressed gas permeability, but since the gas permeability of the plug member is good, it is necessary to put it in an exterior with gas barrier properties as in (1). There is.

  For the type of (3), an oxygen absorbing layer is provided in the intermediate layer of the plug member to improve the gas barrier properties, but since it is integrated with the plug member, there is a possibility of contact during infusion use There is a problem in terms of safety.

  The present invention is intended to solve such problems of the prior art, and is a gas barrier film excellent in safety for easily oxidizable drug solutions (infusion solutions) such as amino acid preparations, glucose preparations and fat emulsions. It is an object of the present invention to provide a plug member for a plastic bag provided with a flexible bag and a plastic tubular port.

  The present invention has been made to solve the above problems, and the invention according to claim 1 of the present invention includes a flexible bag (A) made of a gas barrier film and a plastic tubular port (2). A plug member for a plastic bag, characterized in that a resin composition having an oxygen-absorbing ability that can be detached during use is provided.

The invention according to claim 2 of the present invention is the plug member of the plastic bag according to claim 1, wherein the resin composition having oxygen absorption capacity is at least a thermoplastic resin (resin A) and a C—H bond. A cap member for a plastic bag, which is made of a thermoplastic resin (resin B) having a low dissociation energy.

  The invention according to claim 3 of the present invention is the plug member of the plastic bag according to claim 1 or 2, wherein the thermoplastic resin (resin B) having a small CH bond dissociation energy is carbon at the allylic position. A plug member for a plastic bag, which is any one of thermoplastic resins having benzylic carbon, tertiary carbon, or α-carbon.

The invention according to claim 4 of the present invention is the plug member of the plastic bag according to any one of claims 1 to 3, wherein the thermoplastic resin (resin A) has an oxygen permeability of 100 cm ³ [ 25 μm (thickness) / 1 m ² (area) / 24 h / (1.01325 × 10 ⁵ Pa (pressure)] or more, and is made of polyethylene, an ethylene-α-olefin copolymer, and at least one α-olefin. Polyolefin resin such as α-polyolefin, ethylene-α-olefin copolymer, ethylene-cyclic olefin copolymer, ethylene-α, β unsaturated carboxylic acid or esterified product thereof, ionic cross-linked product thereof, ethylene-vinyl acetate copolymer Grafts of polymers or ethylene copolymers represented by partially saponified products or completely saponified products, or acid anhydrides A plug member for a plastic bag, characterized in that it is a simple substance such as a modified polyolefin resin, polystyrene, polyacrylonitrile, or a mixture of one or more thereof.

  The plug member of the plastic bag according to the present invention is a plug member having a flexible bag made of a gas barrier film and a plastic tubular port. As a result, the shelf life of chemical liquids (infusion solutions) such as easily oxidizable amino acid preparations, glucose preparations and fat emulsions can be extended, and the resin composition with oxygen-absorbing ability can be removed when using infusion solutions. A plastic bag plug member having a flexible bag made of a gas barrier film having excellent properties and a plastic tubular port can be obtained.

  An embodiment of the present invention will be described in detail with reference to FIGS.

  FIG. 1 is a side sectional view showing one embodiment of a plug member of a plastic bag according to the present invention, and FIG. 2 is a side sectional view showing another embodiment of a plug member of a plastic bag according to the present invention. FIG. 3 is a side sectional view showing still another embodiment of the plug member of the plastic bag according to the present invention. FIG. 4 shows the plug member of the plastic bag according to the present invention from the gas barrier film. It is a top view which shows one Example with which the flexible bag (A) which becomes.

  As shown in FIG. 1, the embodiment of the plug member of the plastic bag according to the present invention has an oxygen absorption larger than the area of the tubular port (2) in the outermost exterior of the plastic tubular port (2). The oxygen absorbing layer (1) made of a film having a thickness of about 200 μm is thermally fused, and all the oxygen absorbing layer (1) can be removed during use. A rubber plug (3) is attached in close contact with the inner periphery of the upper portion of the tubular port (2).

  As shown in FIG. 2, another embodiment of the plug member of the plastic bag according to the present invention is formed by integrating a film having an oxygen absorption capacity of about 200 μm and a tablet having an oxygen absorption capacity of 10 mm or less. The oxygen-absorbing layer (4) that has been converted into heat is thermally fused, and all oxygen-absorbing layers (4) can be removed during use. A rubber stopper (6) is attached in close contact with the inner periphery of the upper portion of the tubular port (5).

In another embodiment of the plastic bag plug member according to the present invention, as shown in FIG. 3, the oxygen absorbing layer (7) made of a tablet having an oxygen absorbing capacity within 10 mm in thickness has a shrink film (10 The tablet having oxygen absorbing ability can be removed from the tubular port (8) by removing the shrink film (10) when infusion is used. A rubber stopper (9) is attached in close contact with the inner periphery of the upper portion of the tubular port (8).

  As the resin composition having oxygen absorbing ability, at least a thermoplastic resin (resin A) and a thermoplastic resin (resin B) having a small C—H bond dissociation energy are used.

  Examples of the thermoplastic resin (resin B) having a small C—H bond dissociation energy include any of a thermoplastic resin having an allylic carbon, a benzylic carbon, a tertiary carbon, or an α-position carbon.

  Examples of the allylic carbon-containing compound include conjugated and non-conjugated compounds, including butadiene rubber, isoprene rubber, styrene-butadiene copolymer rubber, styrene-isoprene copolymer rubber, dicyclopentagen, norbornene, and cyclohexene. In addition, alicyclic unsaturated hydrocarbons such as cyclized rubbers or derivatives thereof, and compounds such as unsaturated fatty acid esters of glycerol represented by various oils, carotenoids, and the like can be selected.

  Examples of the compound having benzylic carbon include MXD6 polyamide which is a polymer of xylylenediamine and a polyurethane resin synthesized from an isocyanate derivative of xylylenediamine.

  Examples of the compound having tertiary carbon include a polymer of α-olefin such as propylene, a copolymer with other monomers, an ethylene-vinyl acetate copolymer or a partial (complete) saponified product thereof, polystyrene, ethylene-α, Examples thereof include β-unsaturated carboxylic acid copolymers, esterified products or ionized products thereof, and polyacrylonitrile.

  Examples of the compound having a carbon at the α-position include thermoplastic resins having a carbon atom adjacent to a carbonyl bond, such as aliphatic polyester, aliphatic polyamide, or derivatives thereof, and easily cause an oxidation reaction. If it is a thermoplastic resin, the skeleton type is not ask | required. More preferably, it is better to select a thermoplastic resin having a low crystallinity and a low glass transition temperature. These resins may be used alone or in combination.

  Examples of the thermoplastic resin (resin A) of the present invention include polyethylene, ethylene-α-olefin copolymer, α-polyolefin comprising at least one α-olefin, ethylene-α-olefin copolymer, and ethylene-cyclic olefin. Ethylene-based resins such as polyolefin resins such as copolymers, ethylene-α, β-unsaturated carboxylic acids or esterified products thereof, ionic cross-linked products thereof, ethylene-vinyl acetate copolymers or partially saponified products or completely saponified products thereof Examples thereof include a copolymer, a graft-modified polyolefin resin such as an acid anhydride, a simple substance such as polystyrene and polyacrylonitrile, or a mixture of one or more of these.

  Furthermore, transition metal compound salts such as aromatic carboxylates, saturated or unsaturated carboxylates selected from at least one selected from cobalt, manganese, iron, nickel, copper, rhodium, vanadium, chromium and cerium, or acetylacetonato One or more compounds selected from various transition metal complexes such as ethylenediaminetetraacetic acid, salen, porphyrin, and phthalocyanine may be added.

In addition, as an oxygen-absorbing ability, the unsaturated fatty acids include oleic acid and / or
Alternatively, linoleic acid and / or unsaturated fatty acid esters of glycerol represented by ricinoleic acid and various oils, and carotenoids may be added.

  Moreover, in terms of the package, various additives other than the above, for example, various additives such as a flame retardant, slip agent, antiblocking agent, and UV absorber may be blended in each layer as necessary.

  As a method for producing films and tablets having oxygen absorption capacity provided on the plug member, various predetermined blending amounts of materials set according to the final product molding method and the required oxygen absorption capacity are used as a ribbon mixer, tumbler mixer, Henschel. Kneaded by dry blending using a mixer, etc., or by blending a predetermined amount using each feeder pre-installed in a kneader, extruders such as single-screw extruders and twin-screw extruders, Banbury mixers, etc. It is obtained by kneading using a machine at a melting point of the base thermoplastic resin of 260 ° C. or less, preferably 240 ° C. or less, more preferably 220 ° C. or less.

  As a film and a tablet having oxygen absorbing ability provided on the plug member of the present invention, a laminate can be formed using a molding method such as extrusion lamination molding, extrusion cast molding, inflation molding or the like.

<Example>
Hereinafter, the present invention will be described in more detail with reference to specific examples, but the present invention is not limited thereto.

(Method for producing a film having oxygen absorbing ability)
<Form 1>
Using a three-kind three-layer coextrusion laminating machine, a two-kind three-layer coextruded multilayer film in which a resin composition having oxygen absorbing ability was provided in the intermediate layer was formed. The layer structure is 50 μm / 100 μm / 50 μm from the outside. Polypropylene (PP) was used for the outer layer. This multilayer film was bonded to a base material having gas barrier properties by a dry laminating machine using an adhesive. The sealant part and the tubular port were thermally fused with hot air.

(Method for producing tablets having oxygen absorbing ability)
<Form 2>
Using a mold that can be heated, a tablet of a resin composition having an oxygen absorption capacity was produced. The tablet and the sealant part of the film produced by the above method were heat-bonded to form an integral body, and were heat-sealed to the tubular port by hot air.

(Shrink + method for producing tablets with oxygen absorption capacity)
<Mode 3>
The tablet produced by the above method is fitted into a tubular port and made of biaxially oriented polystyrene (OPS), biaxially oriented polyethylene terephthalate (OPET), biaxially oriented polypropylene (OPP), or biaxially oriented vinyl chloride (OPVC). A shrink film was used to fix the tubular port.

  The following materials were used as materials having oxygen absorption ability.

<Resin A>
・ Polypropylene <Resin B>
・ Polybutadiene <Oxidation catalyst>
・ Manganese stearate <Co-oxidizer>
·oleic acid

  A resin composition having the oxygen-absorbing ability of Form 1 was prepared in the configuration of “100 parts by weight of polypropylene / (30 parts by weight of polybutadiene + 70 parts by weight of polypropylene) / 100 parts by weight of polypropylene (1)” (FIG. 1). It was heat-sealed to the plug member attached to the flexible bag (A) containing 500 ml. Subsequently, the residual oxygen amount after retorting at 121 ° C./30 minutes and leaving at room temperature for 1 day was evaluated using a dissolved oxygen concentration meter. The results are shown in Table 1.

  A resin composition having an oxygen-absorbing capacity of Form 2 was prepared in the configuration of “100 parts by weight of polypropylene / (30 parts by weight of polybutadiene + 70 parts by weight of polypropylene) / 100 parts by weight of polypropylene (4)” (FIG. 2). It was heat-sealed to the plug member attached to the flexible bag (A) containing 500 ml. Subsequently, the residual oxygen amount after retorting at 121 ° C./30 minutes and leaving at room temperature for 1 day was evaluated using a dissolved oxygen concentration meter. The results are shown in Table 1.

  A resin composition having an oxygen-absorbing ability of Form 3 was prepared in a configuration of “100 parts by weight of polypropylene / (30 parts by weight of polybutadiene + 70 parts by weight of polypropylene) / 100 parts by weight of polypropylene (7)” (FIG. 3), and amino acid preparation It was heat-sealed to the plug member attached to the flexible bag (A) containing 500 ml. Subsequently, retort was performed at 121 ° C./30 minutes, and the amount of residual oxygen after standing at room temperature for 1 day was evaluated using a dissolved oxygen concentration meter. The results are shown in Table 1.

  Resin composition having the oxygen-absorbing ability of Form 1 in the configuration of “100 parts by weight of polypropylene / (30 parts by weight of polybutadiene + 69.97 parts by weight of polypropylene + 0.03 parts by weight of manganese stearate) / 100 parts by weight of polypropylene (1)” A product was prepared (FIG. 1) and heat-sealed to a plug member attached to a flexible bag (A) containing 500 ml of an amino acid preparation. Subsequently, retort was performed at 121 ° C./30 minutes, and the amount of residual oxygen after standing at room temperature for 1 day was evaluated using a dissolved oxygen concentration meter. The results are shown in Table 1.

  Form 1 in the configuration of “100 parts by weight of polypropylene / (30 parts by weight of polybutadiene + 68.47 parts by weight of polypropylene + 0.03 parts by weight of manganese stearate + 1.5 parts by weight of oleic acid) / 100 parts by weight of polypropylene (1)” A resin composition having the ability to absorb oxygen (FIG. 1) was prepared and heat-sealed to a plug member attached to a flexible bag (A) containing 500 ml of an amino acid preparation. Subsequently, retort was performed at 121 ° C./30 minutes, and the amount of residual oxygen after standing at room temperature for 1 day was evaluated using a dissolved oxygen concentration meter. The results are shown in Table 1.

A resin composition having the oxygen-absorbing ability of Form 1 was prepared in the configuration of “100 parts by weight of polypropylene / 70 parts by weight of polypropylene / 100 parts by weight of polypropylene (1)” (FIG. 1), and flexible containing 500 ml of amino acid preparation It was heat-sealed to the plug member attached to the bag (A). Subsequently, the residual oxygen amount after retorting at 121 ° C./30 minutes and leaving at room temperature for 1 day was evaluated using a dissolved oxygen concentration meter. The results are shown in Table 1.

表１は、常温にて１日放置した後の残存酸素量の測定結果を記す。

Table 1 shows the measurement results of the residual oxygen amount after being left for 1 day at room temperature.

<Evaluation>
In Example 5 of the present invention, the amount of residual oxygen after standing for one day was the smallest and good. In Example 6, the amount of residual oxygen was very large and bad.

It is a sectional side view which shows one Example of the stopper member of the plastic bag which concerns on this invention. It is a sectional side view which shows the other Example of the stopper member of the plastic bag which concerns on this invention. It is a sectional side view which shows the other Example of the stopper member of the plastic bag which concerns on this invention. It is a top view which shows one Example equipped with the cap member of the plastic bag which concerns on this invention in the flexible bag which consists of a gas barrier film.

Explanation of symbols

DESCRIPTION OF SYMBOLS 1, 4, 7 ... Oxygen absorption layer 2, 5, 8 ... Tubular port 3, 6, 9 ... Rubber stopper 10 ... Shrink film A ... Flexible bag

Claims (4)

  A mouthpiece of a plastic bag comprising a flexible bag made of a gas barrier film and a plastic tubular port, and a resin composition having an oxygen-absorbing ability that can be removed during use. Plug member.   2. The plastic product according to claim 1, wherein the resin composition having oxygen absorption capacity is composed of at least a thermoplastic resin (resin A) and a thermoplastic resin (resin B) having a small C—H bond dissociation energy. Bag plug member.   The thermoplastic resin (resin B) having a small C—H bond dissociation energy is any one of a thermoplastic resin having allylic carbon, benzylic carbon, tertiary carbon or α-carbon. The plug member for a plastic bag according to claim 1 or 2. The thermoplastic resin (resin A) has an oxygen permeability of 100 cm ³ [25 μm (thickness) / 1 m ² (area) / 24 h / (1.01325 × 10 ⁵ Pa (pressure)] or more, polyethylene, Ethylene-α-olefin copolymer, α-polyolefin comprising at least one α-olefin, polyolefin resin such as ethylene-α-olefin copolymer, ethylene-cyclic olefin copolymer, ethylene-α, β unsaturated Graft-modified polyolefin resin such as carboxylic acid or esterified product thereof, ionic cross-linked product thereof, ethylene-vinyl acetate copolymer or ethylene-based copolymer represented by partially saponified product or completely saponified product thereof, or acid anhydride, It is a simple substance such as polystyrene or polyacrylonitrile, or a mixture of one or more of these. The plug member for a plastic bag according to any one of claims 1 to 3.

Images