JP2007135908A - Blood purifying device - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To provide a blood purifying device which can suppress a measurement error, and also, can reduce costs by simplifying the constitution. <P>SOLUTION: This blood purifying device which performs the purification of the blood being taken out from a living body is equipped with an extracorporeal circulation circuit 1, a hemocatharsis section 2 which is provided in the extracorporeal circulation circuit 1, a first flow passage 3 for feeding a dialysis fluid to the blood purifying section 2, a second flow passage 4 for feeding a replacement fluid to the extracorporeal circulation circuit 1, a third flow passage 5 for discharging a filtrated fluid from the hemocatharasis section 2, a measurement section 20, and flow passage switching sections (valves 11 to 13). By the flow passage switching sections, the fluid flowing at least in one flow passage which is selected from among the first flow passages 3, the second flow passage 4 and the third flow passage 5 is guided to the measurement section 20, and the flow rate of the fluid flowing in the selected flow passage is measured by the measurement section 20. <P>COPYRIGHT: (C)2007,JPO&INPIT

Description

  The present invention relates to a blood purification apparatus used for blood purification therapy, particularly continuous renal replacement therapy (CRRT).

  In blood purification therapy, particularly continuous renal adjuvant therapy, blood purification is performed over a long period of 24 hours or more. In blood purification therapy, hemodialysis, hemodiafiltration, and blood filtration are mainly performed, and the measurement accuracy of each flow rate of the dialysate, the replacement fluid, and the filtrate is very important.

  For example, conventionally, the flow rate setting values of the dialysate pump and the replacement fluid pump are used as the flow rates of the dialysate and the replacement fluid, respectively. Further, the flow rate of the drainage discharged from the blood purifier is measured with a graduated cylinder, and the value obtained by subtracting the dialysate flow rate from the measured value is used as the flow rate of the filtrate.

  However, the diameters of the tubes constituting the dialysate circuit, the replacement fluid circuit, and the filtrate circuit vary. In addition, when a roller pump is used as the dialysate pump and the replacement fluid pump, the cross-sectional area of the tube varies due to the pressure variation generated in the tube. For this reason, an error of about 10% may occur between the actual flow rate and the pump flow rate setting value. For example, if treatment is continued for 24 hours, a water overload of several liters may occur, and there is a possibility that treatment adapted to the patient's condition cannot be taken.

In order to solve such a problem, for example, in Patent Document 1, measuring devices are individually installed in the dialysate circuit, the replacement fluid circuit, and the filtrate circuit, and the dialysate flow rate, the replacement fluid flow rate, and the filtrate flow rate are individually set by each measurement device. Discloses a blood purification device that is independently measured. In the blood purification device disclosed in Patent Document 1, the rotation speed of each pump is adjusted so that the actual measurement value actually measured by each measurement device matches the flow rate setting value of each pump. For this reason, the measurement error of each of the dialysate flow rate, the replacement fluid flow rate, and the filtrate flow rate is suppressed to less than 1%.
Japanese Patent No. 3180309

  However, in the above-described blood purification apparatus, it is necessary to separately install measuring devices in the dialysate circuit, the replacement fluid circuit, and the filtrate circuit. This complicates the configuration of each circuit and device and increases the cost.

  In addition, each measuring device has an error, and the error is different for each measuring device. For this reason, when controlling the whole blood purification apparatus based on the measured value of each measuring device, there exists a problem that a control tends to be out of order. Furthermore, since it is cumbersome to correct the error for each measuring device, if it is attempted to correct the error, preparation takes time in an emergency such as a lifesaving emergency.

  An object of the present invention is to provide a blood purification apparatus that can solve the above problems, suppress measurement errors, and can reduce costs by simplifying the configuration.

  In order to achieve the above object, a blood purification apparatus according to the present invention is a blood purification apparatus for purifying blood taken out from a living body, comprising an extracorporeal circuit, a blood purification unit provided in the extracorporeal circuit, A first channel for supplying dialysate to the blood purification unit, a second channel for supplying replacement fluid to the extracorporeal circuit, and a third channel for discharging the filtrate from the blood purification unit. A flow path, a measurement section, and a flow path switching section, wherein the flow path switching section is selected from the first flow path, the second flow path, and the third flow path. The liquid flowing through at least one flow path is guided to the measurement unit, and the measurement unit measures the flow rate of the liquid flowing through the selected flow path.

  As described above, in the blood purification apparatus according to the present invention, since it is not necessary to provide a measurement unit for each dialysate circuit, replacement fluid circuit, and filtrate circuit, the configuration of each circuit and device can be suppressed from being complicated, and further measurement can be performed. It is not necessary to consider the error for each part. Therefore, according to the blood purification apparatus of the present invention, measurement errors can be suppressed as compared with the conventional case, and the cost can be reduced by simplifying the configuration.

  The blood purification device according to the present invention is a blood purification device for purifying blood taken out from a living body, and comprises an extracorporeal circuit, a blood purification unit provided in the extracorporeal circuit, and dialysate to the blood purification unit. A first channel for supplying, a second channel for supplying a replacement fluid to the extracorporeal circuit, a third channel for discharging filtrate from the blood purification unit, and a measuring unit And a flow path switching unit, and the flow path switching unit flows through at least one flow path selected from the first flow path, the second flow path, and the third flow path. The liquid is guided to the measurement unit, and the measurement unit measures the flow rate of the liquid flowing through the selected flow path.

  The blood purification apparatus according to the present invention further includes a time measurement unit and a calculation unit, and the measurement unit includes a container for storing the liquid guided from the selected flow path, and the time measurement unit Measuring the time until a certain amount of liquid guided from the selected flow path is stored in the container, or the time until a certain amount of liquid stored in the container is discharged, However, the amount of liquid stored in the container or the amount of liquid discharged from the container is divided by the time measured by the time measuring unit, and flows through the flow path connected to the measuring unit. It is preferable that the flow rate of the liquid be calculated. According to this aspect, the flow rates of the dialysate, the replacement fluid, and the filtrate can be easily obtained.

  In the above aspect, the flow path switching unit may sequentially select one of the first flow path, the second flow path, and the third flow path. . Furthermore, in the said aspect, the said flow-path switching part can also be set as the aspect which selects the said 1st flow path and the said 2nd flow path simultaneously.

  Furthermore, in the above aspect, a dialysate pump provided in the first flow path, a replacement fluid pump provided in the second flow path, a filtrate pump provided in the third flow path, A controller, and the controller may adjust the discharge amount of the pump provided in the selected flow path based on the flow rate calculated by the calculator.

(Embodiment)
Hereinafter, a blood purification apparatus according to an embodiment of the present invention will be described with reference to FIG. FIG. 1 is a configuration diagram showing a schematic configuration of a blood purification apparatus according to an embodiment of the present invention.

  As shown in FIG. 1, the blood purification apparatus in the present embodiment purifies blood taken out from a living body. The blood purification apparatus includes an extracorporeal circuit 1, a blood purification unit 2, a first channel 3, a second channel 4, a third channel 5, a measuring unit 20, and a channel switching unit. And.

  The extracorporeal circuit 1 includes a blood removal circuit 1a that sends blood removed from a patient (not shown) to the blood purification unit 2, and a blood return circuit 1b that returns blood from the blood purification unit 2 to the patient. It consists of The blood purification unit 2 is provided in the extracorporeal circuit 1 and is connected to the blood blood removal channel 1a and the blood return channel 1b.

  In the present embodiment, the blood purification unit 2 is constituted by a hollow fiber type blood purification device in which a dialysis membrane is formed of a hollow fiber. The blood purification unit 2 is not limited to the hollow fiber type, and may be a laminated type or a coil type. In the present embodiment, the extracorporeal circuit 1 is provided with a chamber 23 in order to prevent foreign substances such as bubbles and blood clots from entering the living body. The chamber 23 includes a mesh inside to remove bubbles and foreign matters.

  The first flow path 3 is a dialysate circuit for supplying dialysate to the blood purification unit 2 and connects the supply port of the container 9 filled with dialysate and the dialysate introduction port of the blood purification unit 2. is doing. The second flow path 4 is a replacement fluid circuit for supplying a replacement fluid to the extracorporeal circulation circuit 1, and connects the supply port of the container 10 filled with the replacement fluid and the extracorporeal circulation circuit 1. In the present embodiment, the second flow path 4 is connected to a connection port (not shown) of the chamber 23 constituting the extracorporeal circuit 1. The third flow path 5 is a filtrate circuit for discharging the filtrate discharged from the blood purification unit 2 to the outside of the apparatus, and is connected to the filtrate discharge port of the blood purification unit 2.

  In the present embodiment, as shown in FIG. 1, the first flow path 3 is provided with a dialysate pump 6, the second flow path 4 is provided with a replacement fluid pump 7, A filtrate pump 8 is provided in the flow path 5. Further, in the present embodiment, roller pumps are used as the dialysate pump 6, the replacement fluid pump 7 and the filtrate pump 8. In addition, the kind of these pumps is not specifically limited, In addition, a finger pump etc. can also be used.

  In addition, initial flow rates are set for each of the dialysate pump 6, the replacement fluid pump 7, and the filtrate pump 8. Furthermore, at the start of blood purification treatment, the rotation speed of each pump is set so that liquid feeding is performed at an initial flow rate set for each pump.

  The flow path switching unit guides the liquid flowing through at least one flow path selected from the first flow path 3, the second flow path 4, and the third flow path 5 to the measurement unit 20 described later. Yes. In the present embodiment, the flow path switching unit includes a valve 11, a valve 12, and a valve 13.

  The valve 11 is provided in a first branch channel 17 branched from the first channel 3. The valve 12 is provided in the second branch flow path 18 branched from the second flow path 4. The valve 13 is provided in a third branch channel 19 that branches from the third channel 5. Further, the first branch channel 17, the second branch channel 18, and the third branch channel 19 are connected to the measurement unit 20.

  Thus, for example, when the first flow path 3 is selected, only the valve 11 is opened, the valve 12 and the valve 13 are closed, and only the dialysate flowing through the first flow path 3 is the first branch flow path. 17 to the measurement unit 20. Similarly, when the second flow path 4 is selected, only the valve 12 is opened, the valve 13 and the valve 11 are closed, and only the replacement fluid flowing through the second flow path 4 is caused by the second branch flow path 18. Guided to the measurement unit 20. Further, when the third flow path 5 is selected, only the valve 13 is opened, the valve 11 and the valve 12 are closed, and only the filtrate flowing through the third flow path 5 is measured by the third branch flow path 19. Guided to section 20. In addition, selection of a flow path is performed by the control part 32 mentioned later.

  The measurement unit 20 includes a first branch channel 17 and a second branch channel 18 from a channel selected from the first channel 3, the second channel 4, and the third channel 5. Alternatively, the flow rate of the liquid guided by the third branch channel 19 is measured. In the present embodiment, the measurement unit 20 includes a container 21 that stores the liquid guided from the selected flow path, liquid level sensors 23 and 24, a vent path 25, and a valve that opens and closes the vent path 25. 22.

  The container 21 is disposed at a position lower than the container 9 filled with the dialysate and the container 10 filled with the replacement fluid. This is because the dialysate and the replacement fluid are guided to the container 21 by using the height difference. Further, the container 21 is connected to the first branch flow channel 17, the second branch flow channel 18, and the third branch flow channel 19 at the lower part thereof. The air passage 25 is provided in the upper part of the container 21.

  The liquid level sensor 23 detects the liquid level set in the upper part of the container 21. The liquid level sensor 24 detects the liquid level set at the bottom of the container 21. When the liquid level sensors 23 and 24 detect the set liquid levels, the liquid level sensors 23 and 24 output detection signals to the time measuring unit 33 described later.

  As shown in FIG. 1, the blood purification apparatus according to the present embodiment also includes a control device 30. The control device 30 further includes a calculation unit 31, a control unit 32, and a time measurement unit 33.

  The time measuring unit 33 measures a time until a certain amount of liquid is stored in the container 21 or a time until a certain amount of the liquid stored in the container 21 is discharged. In the present embodiment, the time measuring unit 33 is connected to the liquid level sensors 23 and 24. The time measuring unit 33 is the time from when the liquid level sensor 24 outputs a detection signal until the liquid level sensor 23 outputs the detection signal, or after the liquid level sensor 23 outputs the detection signal. The time until the level sensor 24 outputs a detection signal is measured.

  For example, when the liquid flows into the container 21 from the first branch flow path 17, the second branch flow path 18, or the third branch flow path 19, the time level measurement unit 33 indicates that the liquid level sensor 24 detects the detection signal. The time from the output until the liquid level sensor 23 outputs the detection signal is measured. On the contrary, when the liquid is stored in the container 21 in advance, the time measuring unit 33 until the liquid level sensor 24 outputs the detection signal after the liquid level sensor 23 outputs the detection signal. Measure the time.

  The amount of liquid stored between the liquid level detected by the liquid level sensor 23 and the liquid level detected by the liquid level sensor 24 is measured in advance, and the measured value is stored in the calculation unit 31. ing. That is, the amount of liquid stored in the container 21 from when the liquid level sensor 24 detects the liquid level to when the liquid level sensor 23 detects the liquid level, and the liquid level sensor 23 The amount of liquid discharged from the container 21 is detected in advance and stored in the calculation unit 31 until the liquid level sensor 24 detects the liquid level.

  The calculation unit 31 calculates the flow rate of the liquid flowing through the selected flow path. Specifically, when the liquid flows into the container 21, the calculation unit 31 puts the liquid into the container 21 between the time when the liquid level sensor 24 detects the liquid level and the time when the liquid level sensor 23 detects the liquid level. The flow rate is calculated by dividing the storage amount of the stored liquid by the time measured by the time measuring unit 33. On the other hand, when the liquid is stored in the container 21, the calculation unit 31 starts from the container 21 until the liquid level sensor 24 detects the liquid level after the liquid level sensor 23 detects the liquid level. The flow rate is calculated by dividing the discharged amount of the liquid flowing out by the time measured by the time measuring unit 33.

  Thus, in this Embodiment, the calculating part 31 calculates a flow volume based on the time which the time measurement part 33 measured. Therefore, in the present embodiment, the calculation unit 31 functions as a part of the measurement unit 20 together with the time measurement unit 33.

  Further, the control unit 32 opens and closes the valves 11 to 13 constituting the flow path switching unit, and opens and closes the valve 25 provided in the vent passage 25 at the upper part of the container 21. Furthermore, in the present embodiment, as shown in FIG. 1, the upstream side of the branch point of the first flow path 3, the upstream side of the branch point of the second flow path 4, and the branch of the third flow path 5. A valve 14, a valve 15, and a valve 16 are also provided on the downstream side of the point. The control unit 32 also opens and closes the valves 14 to 16. Further, the control unit 32 also operates, stops, and adjusts the rotation speed of the dialysate pump 6, the replacement fluid pump 7, and the filtrate pump 8.

  Here, the flow rate measurement performed in the blood purification apparatus in the present embodiment will be described below. First, in order to start blood purification treatment, the control unit 32 opens the valves 14 to 16 and closes the valves 11 to 13.

  Next, when the flow rate measurement is required, the control unit 32 selects at least one of the first flow path 3 to the third flow path 5. Specifically, the control unit 32 opens the valve provided in the branch flow path of the selected flow path among the valves 11 to 13, and each branch flow path of the two unselected flow paths. Each valve provided in is kept closed. In addition, selection of a flow path is performed according to the content previously input into the control apparatus 30 by the operator. In the present embodiment, the selection of the flow path (opening / closing of the valve 11 to valve 13) can also be performed manually by the operator.

  For example, when the third flow path 5 is selected, the control unit 32 opens the valve 13 provided in the branch flow path of the third flow path 5 and closes the valves 11 and 12. Leave. At this time, the control unit 32 opens the valve 25 and closes the valve 16. As a result, the filtrate is guided from the selected third channel 5 to the inside of the container 21 through the branch channel 19.

  Next, when the filtrate is guided from the third flow path 5 to the inside of the container 21 and reaches the liquid level detected by the liquid level sensor 24, the liquid level sensor 24 outputs a detection signal, and the time measuring unit 33. Starts measuring time. Further, when the liquid level in the container 21 rises and the liquid level sensor 23 outputs a detection signal, the time measuring unit 33 ends the time measurement and notifies the calculation unit 31 of the measured time.

  Next, the calculation unit 31 divides the storage amount measured in advance by the time measured by the time measurement unit 33. Thereby, the flow rate of the filtrate flowing through the selected third flow path 5 is obtained. In addition, although not shown in figure, the calculating part 31 can also display the calculated flow volume on a display apparatus.

  Next, the calculation unit 31 notifies the control unit 32 that the calculation of the flow rate has been completed. Upon receiving the notification from the calculation unit 31, the control unit 32 opens the valve 16 on the downstream side of the branch point of the third flow path 5. Thereby, the filtrate stored in the container 21 flows backward to the third flow path 5 via the branch flow path 19. The valve operation by the control unit 32 can be performed simultaneously with the output of the detection signal by the liquid level sensor 23.

  Thereafter, the control unit 32 closes the valve 13. In the present embodiment, the calculation unit 31 can calculate the difference between the initial flow rate of the filtrate pump 8 provided in the third flow path 5 and the calculated flow rate of the filtrate, and the control unit 32 can Depending on the calculated difference, the rotational speed (discharge amount) of the filtrate pump 8 can also be adjusted. In this case, the automatic operation of the blood purification apparatus is possible.

  In addition, for example, when the first flow path 3 (or the second flow path 4) is selected, the control unit 32 causes the branch flow path of the first flow path 3 (or the second flow path 4). The valve 11 (or the valve 12) and the valve 25 provided in the above are opened, and the valve 12 and the valve 13 (or valve 11 and the valve 13) are kept closed. As a result, the dialysate (or replacement fluid) is introduced from the first flow path 3 (or the second flow path 4) into the container 21 through the branch flow path 17 (or the branch flow path 18). .

  Next, when the liquid level of the container 21 rises and the liquid level sensor 23 provided in the upper part of the container 21 outputs a detection signal, the control unit 32 outputs the first flow path 3 (or the second flow path). The valve 14 (or valve 15) on the upstream side of the branch point of 4) is closed. In this state, when the dialysate pump 6 (or the replacement fluid pump 7) is driven, the dialysate (or the replacement fluid) stored in the container 21 passes through the branch channel 17 (or the branch channel 18). It flows backward to the first flow path 3 (or the second flow path 4).

  At the same time as the liquid level sensor 23 outputs the detection signal, the time measuring unit 33 starts measuring time. Furthermore, when the liquid level of the container 21 is lowered due to the backflow of the dialysate (or the replacement fluid) and the liquid level sensor 24 outputs a detection signal, the time measuring unit 33 ends the time measurement and determines the measured time. The calculation unit 31 is notified.

  In addition, when the liquid level of the container 21 exceeds the liquid level detected by the liquid level sensor 23 due to the introduction of the dialysate (or the replacement fluid) into the container 21, the time measurement unit 33 may select the dialysate ( Alternatively, the time measurement can be started when the liquid level sensor 23 outputs the detection signal again due to the backflow of the replacement fluid).

  Next, the calculation unit 31 divides the discharge amount measured in advance by the time measured by the time measurement unit 33. Thereby, the flow volume of the dialysate (or replacement fluid) which flows through the selected 1st flow path 3 (or 2nd flow path 4) is calculated | required. In this case, the calculation unit 31 can also display the calculated flow rate on the display device.

  Next, the calculation unit 31 notifies the control unit 32 that the calculation of the flow rate has been completed. Upon receiving the notification from the calculation unit 31, the control unit 32 controls the valve 11 (or valve) provided in the branch channel 17 (or the branch channel 18) of the first channel 3 (or the second channel 4). 12) is closed. In addition, the control unit 32 opens the valve 14 (or valve 15) upstream of the branch point of the first flow path 3 (or the second flow path 4). The valve operation by the control unit 32 can be performed simultaneously with the output of the detection signal by the liquid level sensor 24.

  Further, similarly to the case where the third flow path 5 is selected, the calculation unit 31 also selects the first flow path when the first flow path 3 (or the second flow path 4) is selected. The difference between the initial flow rate of the dialysate pump 6 (or the replacement fluid pump 7) provided in the path 3 (or the second flow channel 4) and the calculated flow rate of the dialysate (or replacement fluid) can be calculated. Furthermore, the control unit 32 can also adjust the rotation speed (discharge amount) of the dialysate pump 6 (or the replacement fluid pump 7) according to the calculated difference. Also in this case, the blood purification apparatus can be automatically operated.

  As described above, in the present embodiment, the measurement unit is provided in each of the dialysate circuit (first flow path 3), the replacement fluid circuit (second flow path 4), and the filtrate circuit (third flow path 5). Without providing 20, the flow rate of each circuit can be measured. Therefore, it is possible to suppress the configuration of each circuit and device from becoming more complicated than in the past, and it is not necessary to consider errors for each measurement unit. For this reason, according to the blood purification apparatus in this Embodiment, compared with the past, a measurement error can be suppressed and cost reduction can be achieved by simplification of a structure.

  In the above example, one of the first flow path 3, the second flow path 4, and the third flow path 5 is sequentially selected. It is not limited to. For example, this embodiment may be an aspect in which the first flow path 3 and the second flow path 4 are selected simultaneously. This aspect will be described below.

  In the above aspect, the calculation unit 31 calculates the total flow rate of the dialysate flow rate flowing through the first flow path 3 and the flow rate of the replacement fluid flowing through the second flow path 4. Further, the calculation unit 31 calculates the single flow rate of the filtrate flowing through the third flow path 5.

  Furthermore, the calculation unit 31 compares the total flow rate of the dialysate and the replacement fluid with the flow rate of the filtrate, and, for example, the control unit 32 includes the dialysate pump 6 and the replacement fluid pump so that the total flow rate and the filtrate flow rate match. 7 and the number of revolutions of the filtrate pump 8 can be adjusted. In this case, dialysis can be performed only by solute diffusion without removing water or injecting the patient. In addition, it is possible to remove waste products without changing the weight by removing water from the amount injected into the patient's body.

  In addition, when the operator instructs an increase (infusion) of the patient's bodily fluid, the calculation unit 31 instructs the control unit 32 so that the total flow rate of the dialysate and the replacement fluid is larger than the flow rate of the filtrate. The rotational speeds of the dialysate pump 6, the replacement fluid pump 7 and the filtrate pump 8 are adjusted. Further, when the operator instructs the patient to remove water, the calculation unit 31 instructs the control unit 32 so that the total flow rate of the dialysate and the replacement fluid is smaller than the flow rate of the filtrate. The rotational speeds of the dialysate pump 6, the replacement fluid pump 7 and the filtrate pump 8 are adjusted.

  Thus, according to the said aspect, based on the flow rate measured correctly, a fixed quantity of a patient's bodily fluid, a liquid injection to a patient, and also water removal can be performed. Therefore, it is possible to improve the safety of the patient at the time of blood purification therapy.

  The present invention can simplify the circuit and device configuration of the blood purification device, and can contribute to suppression of measurement errors and cost reduction. Therefore, the blood purification apparatus of the present invention has industrial applicability.

FIG. 1 is a configuration diagram showing a schematic configuration of a blood purification apparatus according to an embodiment of the present invention.

Explanation of symbols

DESCRIPTION OF SYMBOLS 1 Extracorporeal circuit 1a Blood removal circuit 1b Blood return circuit 2 Blood purification part (dialyzer)
3 First channel (dialysate circuit)
4 Second flow path (replacement fluid circuit)
5 Third flow path (filtrate circuit)
6 Dialysate Pump 7 Replacement Fluid Pump 8 Filtrate Pump 9 Dialysate Solution Container 10 Replacement Solution Container 11, 12, 13 Valve (Channel Switching Unit)
14, 15, 16, 22 Valve 17 First branch flow path 18 Second branch flow path 19 Third branch flow path 20 Measuring unit 21 Container 23, 24 Liquid level sensor 30 Controller 31 Calculation unit 32 Control unit 33 Time measurement unit

Claims (5)

A blood purification device for purifying blood taken from a living body,
An extracorporeal circuit, a blood purification section provided in the extracorporeal circuit, a first flow path for supplying dialysate to the blood purification section, and a second for supplying a replacement fluid to the extracorporeal circuit. A flow path, a third flow path for discharging the filtrate from the blood purification section, a measurement section, and a flow path switching section,
The flow path switching unit guides the liquid flowing through at least one flow path selected from the first flow path, the second flow path, and the third flow path to the measurement section,
The blood purification apparatus, wherein the measurement unit measures the flow rate of the liquid flowing through the selected flow path. A time measurement unit and a calculation unit;
The measurement unit includes a container for storing the liquid guided from the selected flow path,
The time measuring unit measures a time until a certain amount of liquid guided from the selected flow path is stored in the container or a time until a certain amount of liquid stored in the container is discharged. ,
The arithmetic unit divides the amount of liquid stored in the container or the amount of liquid discharged from the container by the time measured by the time measuring unit, and the flow connected to the measuring unit. The blood purification apparatus according to claim 1, wherein the flow rate of the liquid flowing through the passage is calculated.   The blood purification apparatus according to claim 1 or 2, wherein the flow path switching unit sequentially selects one of the first flow path, the second flow path, and the third flow path.   The blood purification apparatus according to claim 1 or 2, wherein the flow path switching unit simultaneously selects the first flow path and the second flow path. A dialysate pump provided in the first flow path; a replacement fluid pump provided in the second flow path; a filtrate pump provided in the third flow path; and a controller.
The blood purification apparatus according to claim 2, wherein the control unit adjusts a discharge amount of a pump provided in the selected flow path based on the flow rate calculated by the calculation unit.

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