JP2007112814A - Prevention of development and therapeutic/ameliorating agent for troubles of mammary papilla after childbirth - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To plan prevention of development and improvement of troubles of mammary papilla after childbirth. <P>SOLUTION: By massaging of mammary papilla and areola once daily for about 15 minutes with 99% or over of squalane oil during the maternal puerperal period and days 1-5 after childbirth, the occurrence and unfavorable troubles of mammary papilla such as rigidity, edema, redness/blister and crack are prevented. The therapeutic/ameliorating agent decreases pain during breast-feeding and reduces psychological burdens, improves breast milk secretion leading to safe breast-feeding, improves direct breast-feeding after childbirth and furthermore improves nutritional conditions accompanying immunity of infants. <P>COPYRIGHT: (C)2007,JPO&INPIT

Description

  The present invention relates to a method for preventing breasts, mainly teats and areolae in a postpartum pregnant woman immediately after giving birth, eliminating maternal pain and psychological burden, and thus improving the direct breastfeeding rate after childbirth and preventing the occurrence of teat disorders. And to provide an improved therapeutic agent.

  Conventionally, care for the breast immediately after delivery of a maternity woman is insufficient, so that there are many nipple abnormalities such as nipple stiffness, edema, redness / vesicles, and cracks in the puerperium. For this, treatment by symptomatic treatment such as application of ointment has been performed, but there are limits to the treatment of nipples sucked frequently by infants every day, making it difficult to improve nipple abnormalities. As a result, the pain and psychological burden of the mother have not been resolved. As a result, it is impossible to give breast milk that is superior in terms of imparting nutritional value, nutritional lance, and immunity to infants, and there is no choice but to shift to artificial milk. It was in a situation that had to move to artificial milk with poor contact.

On the other hand, breasts are conventionally massaged in order to improve the milk output, but the conventional method of simply massaging the breasts slightly improves the milk output. It was difficult to improve papillary abnormalities such as papillary stiffness, edema, redness / hydration, and cracks during the postpartum period. In other words, nipple stiffness is a symptom that is common among mothers with large nipples, and the nipple is hard and rubbery and often does not give enough breast milk even after breastfeeding. There were also problems such as failure to improve obstruction and progression to mastitis. Also, in the case of a crack, the nipple is cleaved, and there is a problem that it is not completely cured by massage or treatment with a therapeutic agent because it causes severe pain each time breastfeeding.
In addition, there were similar problems in symptoms such as redness and water bubbles.
As a result, breastfeeding, which is indispensable for infants, is not only possible, but the situation is worsened by frequent breastfeeding, and there is a situation in which it is necessary to move to inorganic artificial milk without parent-child contact. It was.

  As a method for improving these, there is also an attempt to improve the abnormality of the teat by applying absorbent cotton soaked with olive oil to the teat and areola, and leaving it for about 10 to 15 minutes (see Non-Patent Document 1, for example). Although it is carried out, there is a concern in terms of safety, so it is necessary to bathe and then wash away with soap, which is cumbersome as a procedure and insufficient for improving nipple abnormalities.

Obstetrics and gynecology treatment: vol.85, no.4, p382-386 (2002/10))

  As described above, the current situation is that an excellent method for improving the lactation rate has not yet been established, and nipple abnormalities such as nipple stiffness, edema, redness / vesicles, and cracks in postpartum pregnant women immediately after childbirth. The purpose is to provide a method and an agent for measuring improvement and eliminating maternal pain and psychological burden, and thus improving the direct breastfeeding rate after delivery.

  In view of the above problems, the present inventors have conducted extensive research on methods for preventing nipple abnormalities and improving the direct feeding rate of breast milk during the puerperium of pregnant women, and as a result, the present invention has been completed.

  That is, the present invention prevents nipple disorders by applying squalane oil to the nipples and areola once a day from the first day to the fifth day after delivery in the pregnant woman's postpartum period, and directly after delivery. It is a method for improving the breastfeeding rate, and is a preventive and ameliorating therapeutic agent for nipple disorders including nipple stiffness, edema, redness / hydration, and cracks after childbirth.

For nipple disorders during the postpartum period, nipple stiffness, edema, redness / vesicles, cracks, etc. are regarded as problems of nipples that inhibit breastfeeding.
Nipple stiffness is more common among mothers with large nipples, and the nipples are hard and rubbery, and breastfeeding does not produce enough breast milk. If this is the case, it may develop into mastitis and lead to serious disability.

  In addition, edema is a breast fullness that occurs early in the second to third days of the postpartum period. The increase in inflow of arterial blood to the breast after childbirth, while the outflow of venous blood stagnates. It is a symptom of a condition in which congestion and edema occur due to balance.

Redness is a symptom of dull pain or painful conditions in which the epidermis of the breast is reddish and scratched due to clogging of the breast plug.
In addition, vesicles are common in mothers who are breastfeeding for the first time, and there are cases in which the nipples form vesicles while breastfeeding frequently, sometimes accompanied by cracks, which is very painful for mothers. Like the milk dregs, the vesicles become milky congested milk where the milky mouth is closed and breast milk does not come out, and show symptoms that feel hard and lump. When this symptom worsens, mastitis may accompany and painful fever may occur. There are methods for treating antibiotics, but incision may be performed to remove accumulated pus.

  In addition, cracks are caused by clogging of the nipple, etc., and mothers with weak nipple skin have cracks in the skin due to sucking the baby when breastfeeding, and sometimes breastfeeding is stopped due to pain. This is a very serious symptom.

  The present invention is a method for ameliorating the nipple disorders listed above, and is an effective and reliable treatment method for eliminating disorders that have been painful to the mother so far. It is a preventive and ameliorating treatment agent.

  That is, in the postpartum postpartum period, the present invention provides a nipple disorder, edema, redness / water by massaging after applying a preventive and ameliorating treatment for nipple disorders consisting of once-daily squalane oil to the nipple and areola in the nipple. Since nipple abnormalities such as cysts and fissures can be prevented, pain and psychological burden during breastfeeding are reduced, and breastfeeding is improved and safe breastfeeding becomes possible. As a result, the direct breastfeeding rate, which has been declining in recent years, is significantly improved during the specific period after delivery, improving the nutritional status of the infant and the immunity associated therewith. The touch of the skin of the mother and the child who was there will increase, and a healthy baby can be nurtured.

  The squalane oil used in the present invention is obtained by reducing squalene. That is, squalene is present in liver oil of deep-sea sharks, or in plants such as olive oil and cottonseed oil, and is also present as a human skin component, but squalane can be obtained by reducing this with hydrogen. Normally, squalene in animals and plants that exist in nature contains a large amount of impurities, so this is extracted or distilled in advance to purify the squalene content to a high purity of 99% or more and reduce this to reduce squalene. can get. Squalane is a saturated fat, and it is a liquid oil with very little oxidation and alteration, and excellent stability.

  The squalane oil used in the present invention is supposed to enter the mouth from the nipple when the infant is breastfeeding after application, but even in that case, safety must be ensured. High purity products are desirable. That is, a squalane oil having a purity of 90% or more, preferably 99% or more, more preferably 99.9% or more is used.

The squalane oil obtained as described above is a tasteless, odorless, colorless liquid oil, does not contain unidentified substances, has no stickiness, is slippery and has an excellent feel, so that it can be applied to the breast. Ideal and unparalleled. In addition, squalene oil and squalane oil are produced in a small amount in a human body and are excellent in safety because they are sebum components. For this reason, it is familiar to our skin and is widely used as a cosmetic oil because of its softness.
Squalane oil having the above characteristics is an oil for massage of nipples and nipples important for improving the breastfeeding rate of the present invention, is a nipple abnormality prevention for massage, a breastfeeding rate improving agent, and prevention of occurrence of nipple disorders. And an improved therapeutic agent.

By the way, with a widow (8 first-born women, 5 parous women, 13 people in total) as subjects, nipples and areola once a day from the first day of delivery, squalane oil and olives conventionally used in maternity hospitals, etc. After applying the oil alternately, massage was performed to examine the feeling of use of each. As a result, the following evaluation was obtained for the feeling of use when olive oil was applied.
Slimy, sticky ... 7 people
No effect on scratches, etc ... 3 people
Almost the same as or higher than squalane oil ... 2 people
I don't know …………………………… 1 person As mentioned above, olive oil is accompanied by discomfort such as stickiness, so there are many subjects who hesitate to apply and evaluation that it is not effective in improving nipple disorders Met. On the other hand, squalane oil has no stickiness and has a smooth feel, and since it can feel the effect on the nipple disorders shown below, it was an evaluation that the subject wanted to use continuously.
The olive oil used for this evaluation contained about 70% squalene, but it was not satisfactory from the viewpoint of feeling of use and improvement of nipple disorders.

  Nipple disorders for which improvement effects are observed using the squalane oil of the present invention are various symptoms that develop in the teats that inhibit breastfeeding such as nipple stiffness, edema, redness / hydration, and cracks. Is applied to the nipples and areola and massaged, so that nipple abnormalities are suppressed and the direct breastfeeding rate is significantly improved.

By such a method of the present invention, the milk output becomes normal, and the feeding rate of breast milk, which has been decreasing in recent years, is improved. Therefore, a healthy baby can be raised.
Hereinafter, the excellent effect of the present invention in the same maternity hospital will be described in detail.

  Pregnant women giving birth at maternity hospitals once a day from the first day to the fifth day of squalane oil (use 99.95% high-purity squalane oil sold by Harbor Research Laboratories) once / day teat and areola S group (411 cases) was applied to the body and massaged for about 15 minutes, and the breast feeding rate was determined from the number of breastfeeding on the 6th day and 1 month after birth, and the effect of improving the breastfeeding rate with squalane oil was observed. did. The group which massaged without applying squalane oil as a subject was defined as group C (414 cases) and compared with the breastfeeding rate after 6 days and 1 month after birth.

  In addition, Table 1 shows the results of observing the effects of Squalane oil by observing the direct breast milk ratio of the S group and the C group, which were fed directly after 6 days and 1 month after birth.

  As shown in Table 1, a massage group in which squall oil was applied to the teats and areola once a day and massaged, and the breastfeeding rate after 6 days (S group) was 88.6%, and no squalane oil was applied. Compared with the breastfeeding rate of 49.8% in (Group C), the feeding rate was significantly higher, approximately twice (p <0.05). In addition, this lactation rate was high even after one month, and the S group showed a significantly higher value of 45.7% compared to 24.4% in the C group (p <0.05), and the application of squalane oil Nipple and areola massage was clearly effective in breastfeeding rate.

  Similarly, the direct breastfeeding rate was also good, with group C showing only 34.3% after 6 days, compared to 71.5% in group S, approximately twice as significantly higher Rate was indicated (p <0.05). In addition, even after one month, the C group had a low rate of 22.2%, whereas the S group showed 42.6%, an improvement of the breastfeeding rate of direct breast milk (p <0.05).

As described above, it is apparent that the effect of squalane oil is remarkable even in direct breastfeeding and the method of the present invention is excellent.
In addition, no side effects of breast milk massage due to the application of squalane oil were observed, and there was no effect on both mothers and children.

  Furthermore, the application effect of the squalane oil of the present invention will be clarified below for the improvement effect of the nipple abnormality. In other words, nipple abnormalities are symptoms that occur in nipples that inhibit breastfeeding such as nipple stiffness, edema, redness / vesicles, and fissures, but these symptoms can be improved or prevented by the method of the present invention. To clarify.

That is, the group that performed massage (once / day) for 1 week after applying squalane oil to the areola and nipple was designated as group S, and the group that was massaged without applying squalane oil as group C, and nipple stiffness / edema, The improvement effect was observed with respect to redness, water vesicles and cracks, and each was compared.
Table 2 shows the data of the improvement effect.

    As a result, as shown in Table 2, post-application massage (once / day), compared to Group C, which did not apply squalane oil in any of nipple stiffness / edema, redness / vesicles, and cracks, as shown in Table 2. ) For 1 week, the breastfeeding rate was significantly improved (p <0.05). In particular, redness / vesicles were 15.2% in the C group and 76.2% in the S group, and the effect of improving papillary disorders was significant (p <0.05), and the stiffness / edema and cracks were also significant. The improvement effect was recognized (p <0.05), and it was clear that the 1-day / day massage effect of nipple and areola by applying squalane oil was effective.

  Next, Table 3 shows the effect of preventing the onset of nipple abnormalities in widows by the method of the present invention. As described above in Table 3, the group in which massage (once / day) was performed for 6 days without applying squalane oil was defined as group C, and the group S in which massage was performed by applying squalane oil for the same period; Contrast.

  As a result, the number of widows who had no abnormal findings on the first day was 286 in group C and 294 in group S. This value generally tends to decrease with the number of days after puerperium, and in fact, the number of cases without abnormal nipple development after 6 days was 36 in the C group. On the other hand, the S group massaged by applying squalane oil showed significant improvement in 54 cases and cases without abnormal nipple development, and the incidence of nipple abnormalities also increased from 12.6% to 18.4%. (P <0.05), clearly confirming the application effect of squalane oil on the lactation rate.

  INDUSTRIAL APPLICABILITY The present invention is effective as a preventive and ameliorating therapeutic agent for nipple disorders such as papillary rigidity, edema, redness / hydration, and cracks after childbirth, and has great utility as a medicine.

Claims (3)

A preventive and ameliorating treatment for nipple disorders including post-partum nipple stiffness, edema, redness, blisters, and cracks, comprising squalane oil purified to a purity of 90% or higher. The agent according to claim 1, wherein the squalane oil has a purity of 99% or more. The agent according to claim 1 or 2, wherein the squalane oil has a purity of 99.9% or more.