JP2007111018A - Animal feed, animal rearing method, livestock and fish food and health food - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To provide a food having remaining antibiotic reduced as much as possible, and effects of remaining antibiotic to a man, reduced as much as possible. <P>SOLUTION: Animal feed contains parsley (scientific name:Petroselinum crispum) or the derivative product of the parsley (hereinafter referred to as a parsley derivative product). An animal rearing method comprises letting an animal ingest the parsley or parsley derivative product so as to discharge antibiotic from the inside the body of the animal. Livestock and fish food is obtained from the animal which ingests the parsley or the parsley derivative product. Health food contains the parsley or parsley derivative product. <P>COPYRIGHT: (C)2007,JPO&INPIT

Description

  The present invention is an animal feed having a function of discharging antibiotics, a breeding method for discharging antibiotics from the body of the animal, a livestock and fishery food obtained from animals that have discharged antibiotics, and a function of discharging antibiotics. It relates to health foods.

  In recent years, the food industry has attracted the most attention on how to supply healthy food ingredients that consumers demand. Safety, which has been emphasized in the past, is already taken for granted, and securing higher quality foods is the most important point when consumers are evaluated. In order to meet this demand, attention has been paid to the construction of a system (traceability = production history management) that enables the end consumers to trace the origin of the food they purchased.

  Until now, the Japanese fishery industry has gathered the world's most advanced technologies for freshness management. As a result, it has become possible to supply seasonal seafood in a fresh state regardless of the season or place. To this end, it must not be overlooked that there have been advances in aquaculture technology to manage ultra-low temperature storage, low-temperature distribution systems, and catch fish on demand when needed. About 20% of the annual catch of about 6 million tons produced in Japan is produced by sea surface aquaculture, and various ingenuities have been put into the cultivation of these high-class fish, but problems still remain. .

  A typical example is the in-vivo residues of antibiotics used to treat or prevent diseases. The use and management of residual antibiotics are strictly regulated not only for marine products, but also for livestock products such as pigs and birds, because there are concerns about the effects of the food chain on the people who eat them.

  In other words, the period of drug use, the amount used, and the drug withdrawal period until the drug can be shipped after the last administration, are regulated by the Pharmaceutical Affairs Law. And compliance is required.

  In the first half of 2004, the Ministry of Health, Labor and Welfare conducted a veterinary drug inspection of imported foods that pointed out violations of antibiotics and synthetic antibacterial agents in farmed fish such as shrimp and eel.

  Amid the growing interest in food safety, the Food Sanitation Law was revised in May 2003, and a “positive list system” was introduced for veterinary drugs. This is a system that stipulates a certain amount of standard for veterinary drugs and feed additives whose food residue standards are not set by law, and prohibits the distribution of foods exceeding that standard. The number of veterinary drugs for which residual standard values have been set is 31 as of September 2004, but provisional standards are scheduled to be newly set for about 200 drugs by May 2006. .

  Orthotetracycline (OTC), the most widely used antibiotic for farmed fish, is a type of tetracycline drug that exhibits a broad antibacterial spectrum against Gram-positive and negative bacteria, and is widely used as a feed additive in aquaculture Has been.

  Antibiotics should be used for the treatment of diseases, but unlike livestock animals, once they become sick, the rate of infection among fish rearing in the same aquarium is quite high, so this is a long-time farmer. It is said that it is a common practice in the industry to observe fish well and administer medication before bacteria are actually confirmed.

  When this antibiotic is orally administered to humans, gastrointestinal side effects are known, and in large doses, gastrointestinal disorders and liver disorders are also known. In the case of farmed fish, it is widely used for the treatment of infectious diseases such as vibrio and hemolytic streptococci, and in the case of OTC, the usual dose is about 50 mg per kg fish weight.

  When antibiotics are continuously administered for treatment, some are metabolized and excreted from the body, but some are mainly maintained at high concentrations in organs such as the liver, and as a result, also in the muscles that are eaten It is known to remain for a certain period through the bloodstream.

  The current OTC residue permission standard in Japan is 0.6 ppm as the sum of three kinds of tetracycline antibiotics of OTC + CTC + TC in livestock meat, etc. In the case of seafood, only OTC is 0.2 ppm, and even CTC + TC is detected even slightly It should not be done.

The time taken to reach this level after the end of dosing depends not only on the dose and the number of days of dosing, but also on the ambient water temperature, and becomes considerably longer particularly in the low temperature period. For this reason, it is known that it takes at least 10 days, and it is common to provide a drug holiday of about one month for safety. Specifically, according to the provisions of the Pharmaceutical Affairs Law, 20 days before landing in yellowtail, red sea bream, etc., 30 days in coho salmon, rainbow trout, eel etc. Is supposed to be established.
JP 05-308908 A Supervised by Yutaro Hosokai and Masao Matsumoto “Food Safety Seminar 4 Animal Drugs and Feed Additives” Central Law 2001

  In this way, the antibiotics currently administered to farmed fish are brought below the residual concentration that is considered safe by providing a drug holiday.

  However, the establishment of a drug holiday does not mean that antibiotics have disappeared from the body of farmed fish. Recent consumers, especially pregnant women and mothers with small children, are quite anxious about harmful substances in food, even if they are below residual levels that are considered safe by law. It is difficult to accept a small amount of antibiotics. That is, consumers want farmed fish with as little antibiotic as possible.

  In view of such a situation, the present invention aims to provide a food that has as few residual antibiotics as possible and has as little influence on humans as possible from residual antibiotics.

  The animal feed according to the present invention is characterized by containing parsley or a product derived from the parsley (hereinafter referred to as “parsley-derived product”). In addition, the animal breeding method according to the present invention is characterized in that the animal is ingested with parsley or a parsley-derived material, and antibiotics are discharged from the body of the animal. The livestock and fishery products according to the present invention are characterized in that they are obtained from an animal fed with parsley or a parsley-derived product. In addition, the health food according to the present invention is characterized by containing parsley or a parsley-derived material.

  Here, the parsley refers to a plant identified by the scientific name Petroselinum crispum. As the parsley-derived material, a hot water extract of parsley or a crushed product of heated parsley can be used. Parsley or parsley-derived material is mixed with animal feed and consumed by animals. As animal feed, conventionally known animal feed can be used, and it is not necessary to use a special one.

  As the antibiotics to be excreted, tetracycline antibiotics can be mentioned in particular. As the tetracycline antibiotics, oxytetracycline (OTC), chlorotetracycline (CTC), and tetracycline (CT) can be mentioned. Considering that tetracycline antibiotics are protein synthesis inhibitors, other antibiotics of the same type (Aminoglycoside, Chloramphenicol, Macrolide, Lincomycin, Mikamycin, etc.) may also have an elimination effect. It is.

  Examples of livestock and fishery products include beef, pork, chicken, chicken eggs, milk, honey, cultured seafood, and processed foods thereof. included. In addition, although the Example mentioned later demonstrates the example which experimented using the flounder as an experimental animal, livestock and fishery foods are not limited to fish, The same result is obtained also in the other animal.

  According to the present invention, it is possible to greatly reduce the concentration of antibiotics remaining in the body of an animal more than naturally reducing, and to significantly reduce the effects of residual antibiotics on humans who consume livestock and fishery products. There is an effect.

  Further, according to the present invention, since the discharge of antibiotics remaining in the animal body can be promoted using an inexpensive food material called parsley or a parsley-derived material, the concentration of antibiotics remaining in the animal body can be reduced. There is an effect that it can be reduced at a low cost.

  In addition, according to the present invention, since it is possible to promote the discharge of antibiotics remaining in the animal body using a safe food material called parsley or a parsley-derived material, the safety of the material that promotes the discharge of antibiotics There is an effect that it is not necessary to confirm again.

  In addition, according to the present invention, since the concentration of residual antibiotic can be reliably reduced, there is an effect that it is possible to surely eliminate the possibility that residual antibiotic is detected in animals to be shipped.

  Further, according to the present invention, since the discharge of antibiotics remaining in the mother's body can be promoted, breast milk containing no antibiotics or almost no antibiotics can be given to infants. The effect is that you don't have to worry about the negative effects of antibiotics that may be contained in it.

  In addition, the present invention has the effect that, when the Pharmaceutical Affairs Law is revised in the future and the drug withdrawal period is shortened, it is possible to treat with antibiotics even in the case where infection is caused by refraining from shipping soon. There is.

  The objective of reducing the concentration of residual antibiotics in animals as much as possible was achieved by a simple and inexpensive means of feeding animals with parsley or parsley-derived material.

  Wash the parsley (Petroselinum crispum) with water, pass through hot water at around 90 ° C for 1-2 minutes to inactivate the enzymes, rub down with a juicer, separate the juice and solids by centrifugation or filtration, Sterilization was performed at 80 ° C. for about 10 to 30 minutes, and the mixture was concentrated about 50 times. When this concentrated juice is calculated from the production record, 1 kg contains a component corresponding to 8.67 kg of parsley raw grass.

  In addition, about 200 flounder with an average body weight of 334 ± 53 g and a body length of 311 ± 18 mm, the amount of OTC uptake calculated from the average feeding rate per body weight is 100 ppm (100 mg (titer) / kg fish weight). The prepared mixed feed was fed at a constant amount (0.7% / body weight) for 7 days.

  Moreover, the test fish which fed the mixed feed of the same composition which does not contain OTC was also prepared, and this was made into the negative control group.

  On the day after the end of the dosing period, five flounder in the OTC feeding group (positive control group) and five flounder in the negative control group were taken up and dissected to measure OTC concentrations in the liver and muscle.

  From the day after the end of the dosing period, a positive control test group that was fed only with a normal mixed fish feed, a test group that was fed with a mixed feed for fish farming that contained parsley juice in 2g / kg BW (2 g per kg of fish body weight) In addition, a total of 4 test sections were prepared: a test plot fed with a mixed feed for fish farming added with pantothenic acid 100 mg / kg BW, which is thought to promote metabolism, and a test plot added with walleye pollack liver oil 600 mg / kg BW thought to promote metabolism, The flounder was raised continuously. The feeding rate during this period is 1% / body weight / day.

  Every 5th day, 10th day, 20th day, 30th day and 40th day, 5 fish were taken from each test group, dissected, and OTC concentrations in liver and muscle were measured.

  The measurement results were divided into two parts, liver and muscle, and summarized in a graph. FIG. 1 is a graph showing changes in OTC concentration remaining in the flounder liver, and FIG. 2 is a graph showing changes in OTC concentration remaining in the flounder muscle.

  As is apparent from the above two graphs, the period in which OTC remains in the muscle is longer than that in the liver, and in order to decrease to a regulated value of 0.2 ppm or less except in the parsley juice addition test section, 10-15 It takes about a day.

  Although the liver is an organ that produces various drug-metabolizing enzymes, the elimination proceeds faster than the muscle, but it still reaches the regulated value of 0.2 ppm or less, but it is 9-12 except for the parsley juice addition test section. It takes days.

  On the other hand, in the test section where parsley juice was blended, both the liver and muscle decreased to 0.2 ppm in 4 to 4.5 days, and almost reached the detection limit on the 10th day. there were.

  Taking the above results together, it can be seen that parsley juice is effective in promoting the elimination of the antibiotic OTC from the living body.

  Considering the normal metabolic process of drugs in vivo, it is considered that the activity of drug metabolizing enzymes in the liver is activated by ingestion of parsley juice, and as a result, the rate of excretion of residual antibiotics is remarkably accelerated. Therefore, the present invention may be applicable to the promotion of the elimination of other harmful substances excreted by the liver in addition to antibiotics.

It is a graph which shows the change of the OTC density | concentration which remains in the flounder liver. It is a graph which shows the change of the OTC density | concentration which remains in the soleus muscle.

Claims (5)

  Animal feed comprising parsley or a product derived from the parsley (hereinafter referred to as “parsley-derived product”).   An animal breeding method comprising causing an animal to ingest parsley or a parsley-derived material to excrete antibiotics from the body of the animal.   The method for raising animals according to claim 2, wherein the antibiotic is a tetracycline antibiotic.   A livestock and fishery food product obtained from an animal ingested with parsley or a parsley-derived product.   A health food comprising parsley or a parsley-derived material.

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