JP2007055647A - Sleeve for chemical filling container and its production method - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To provide a sleeve for a chemical filling container which keeps the internal peripheral face superior in abrasion resistance, is hardly scratched and is used for a long time and which does not damage the internal peripheral face of a cylinder container, and to provide the production method of the sleeve. <P>SOLUTION: This sleeve for a chemical filling container made of a superior corrosion resisting metal material is used for pushing in a container plugging gasket 7 into a container 4 being sent into the container 4 filled with chemical powder or liquid 5. The sleeve comprises a sleeve holding thick cylindrical part 2 at the top side of the sleeve and a thin cylindrical part 3 extending from the part 2 to the bottom end of the sleeve. The whole area of the internal peripheral face of the sleeve 1 is made of a high stiffness layer and the outer peripheral face of the part 3 is made of a low stiffness layer. <P>COPYRIGHT: (C)2007,JPO&INPIT

Description

  The present invention relates to a sleeve for a medicine-filled container made of a metal material having excellent corrosion resistance for entering a cylinder container filled with medicinal powder or liquid from its upper end opening and pushing a gasket for closing the container. The present invention relates to a sleeve for a medicine filling container comprising an extremely thick cylindrical portion for holding a sleeve on the upper side and an extremely thin cylindrical portion extending from the extremely thick cylindrical portion to the lower end of the sleeve.

  Referring to FIG. 1 showing an embodiment of the present invention, which will be described later, a method for using a sleeve for a medicine filling container will be described. In this figure, 1 is a sleeve for a medicine filling container made of stainless steel, and an upper sleeve holding electrode. It consists of a thick cylindrical portion 2 and an ultrathin cylindrical portion 3 that extends to the lower end of the sleeve with the same inner diameter as this very thick cylindrical portion 2, and the thickness of the ultrathin cylindrical portion 3 is 0.1 to 1.0 mm. It is very thin. Reference numeral 4 denotes a cylinder container filled with medicinal powder or liquid 5, and has a lower end portion that has an opening 4 b that is squeezed to reduce the diameter, and is called a syringe. Reference numeral 6 denotes a pusher made of a rod-like body, and a gasket (rubber plug) 7 made of a rubber-like elastic material is pushed into the sleeve 1, and the gasket 7 is inserted from the lower end of the sleeve 1 into a cylinder container filled with medicinal powder or liquid 5. The container 4 is pushed out to be closed. It should be noted that the thickness of the cylindrical portion 3 is made extremely thin as described above by reducing the difference between the inner diameter of the cylindrical portion 3 and the inner diameter of the cylinder container 4 as much as possible, and the gasket 7 from the sleeve 1 into the cylinder container 4. This is to ensure that the fitting is performed accurately.

  In the filling operation of the medicine into the cylinder container 4, the cylinder container 4 with the lower end opening 4b closed by the cap 8 is filled with medicinal powder or liquid 5, and then the upper end opening 4a of the cylinder container 4 is filled. Further, the ultrathin cylindrical portion 3 of the sleeve 1 is inserted into the sleeve 1, and the gasket 7 is pushed into the sleeve 1 from the upper end opening 1a by the pusher 6, and the pusher 6 is connected to the inner periphery of the ultrathin cylindrical portion 3 of the sleeve 1. While pushing the gasket 7 along the surface, it is pushed into the cylinder container 4 from the tip of the ultrathin cylindrical portion 3, and the gasket 7 is fitted into the cylinder container 4 as shown in the phantom line to close it. ing.

  In the filling operation of the medicine, the above-described steps are repeatedly performed. Therefore, the sleeve for the medicine filling container that has been conventionally used is formed on the inner peripheral surface of the sleeve by the sliding action of the gasket 7 by the pusher 6 being pushed. Wear is fast, and the inner peripheral surface of the sleeve is scratched by a vertical stripe pattern. This scratch also causes a vertical stripe pattern scratch on the outer peripheral surface of the gasket 7, and the confidentiality of the gasket 7 is likely to be impaired. Had to be replaced.

  Despite the fact that conventional chemical-filled container sleeves are made of stainless steel, which is a metal material with excellent corrosion resistance because of contact with various chemicals, the sleeve inner peripheral surface wears quickly and is easily damaged. This is because the hardness of SUS304 or SUS316L currently used as stainless steel having excellent corrosion resistance is as low as around Hb160. Incidentally, SUS630 with high hardness has a problem in corrosion resistance.

  However, it is conceivable to increase the surface hardness of the sleeve by nitriding even with a low hardness stainless steel as described above, but a temperature of 400 to 600 ° C. is always required for any nitriding treatment. At such a temperature, the extremely thin cylindrical portion has a very thin thickness of 0.1 to 1.0 mm, so that the cylindrical portion itself is deformed and nitriding cannot be performed.

  Therefore, most of the sleeves for chemical filling containers that are currently used are made of SUS304 or SUS316L. However, because the hardness is low, the inner peripheral surface of the sleeve is easily damaged, and it is deformed during setting, storage, and cleaning. There was a problem that it had to be replaced with a new gasket at an early stage.

  In view of the above problems, the present invention has good wear resistance on the inner peripheral surface of the sleeve, is hardly scratched, has a long service life, and does not damage the inner peripheral surface of the cylinder container by the sleeve. It is an object of the present invention to provide a sleeve for a medicine-filled container and a method for producing the sleeve.

Means for solving the above problems will be described with reference numerals of the embodiments described later. The medicine filling container sleeve of the invention according to claim 1 is a cylinder container 4 filled with medicinal powder or liquid 5. A sleeve for a medicine-filled container made of a metal material having excellent corrosion resistance for pushing into the container closing gasket 7 through the upper end opening 4a into the container, and is an extremely thick cylindrical portion 2 for holding the sleeve on the sleeve upper side. And a sleeve for a medicine-filled container comprising an extremely thin cylindrical portion 3 extending from the extremely thick cylindrical portion 2 to the lower end of the sleeve,
The entire inner peripheral surface of the sleeve is made of a high hardness layer 10, and the outer peripheral surface side of the ultrathin cylindrical portion 3 is made of a low hardness layer 11.

  The invention according to claim 2 is a method of manufacturing a sleeve for a medicine filling container according to claim 1, wherein a cylindrical workpiece W having a predetermined length made of a metal material having excellent corrosion resistance is provided along its axis. A hole 12 having a predetermined inner diameter extending through the entire length is provided and the inner peripheral surface of the hole 12 is finished, and then the entire surface of the workpiece W including the inner peripheral surface of the hole 12 is subjected to surface hardening treatment, and the surface is hardened. The ultrathin cylindrical portion 3 having a predetermined thickness is formed by cutting the outer peripheral surface side of the cylindrical portion 13 for forming the ultrathin cylindrical portion extending from one end of the workpiece W to a predetermined length.

  According to a third aspect of the present invention, in the method for manufacturing a sleeve for a medicine filling container according to the second aspect, the outer peripheral surface side of the cylindrical portion 13 for forming the ultrathin cylindrical portion extending from one end of the surface-hardened workpiece W to a predetermined length is subjected to cutting. Thus, the ultrathin cylindrical portion 3 having a predetermined thickness is formed, and the surface hardened portion on the one end surface side of the workpiece W is cut off.

  The effect of the invention by the above solution will be described with reference numerals of the embodiments described later. According to the invention according to claim 1, since the entire inner peripheral surface of the sleeve 1 is made of the high hardness layer 10, the gasket By the sliding action of 7, the inner peripheral surface of the sleeve 1 is hardly damaged and the service life can be extended. Further, since the outer peripheral surface side of the ultrathin cylindrical portion 3 is composed of the low hardness layer 11, when the ultrathin cylindrical portion 3 enters the cylinder container 4, the outer peripheral portion of the ultrathin cylindrical portion 3 causes the inner peripheral surface of the cylinder container 4. The life of the cylinder container 4 can be extended.

  According to the second aspect of the invention, the medicine filling container sleeve 1 in which the entire inner peripheral surface of the sleeve is made of the high hardness layer 10 and the outer peripheral surface side of the ultrathin cylindrical portion 3 is made of the low hardness layer can be easily and accurately made. Can be manufactured.

  According to the invention of claim 3, when the ultrathin cylindrical portion 3 enters the cylinder container 4, the tip of the ultrathin cylindrical portion 3 is less likely to damage the inner peripheral surface of the cylinder container 4. 4 lifespan can be extended.

A preferred embodiment of the present invention will be described below with reference to the drawings. FIG. 1 is an explanatory cross-sectional view illustrating a method for using a sleeve 1 for a medicine filling container according to the present invention, and FIG. The cross-sectional enlarged front view of the sleeve 1 for a medicine filling container shown, (b) is a partially enlarged cross-sectional view of the sleeve 1, (c) is (b)
It is an enlarged view of the part shown by arrow X. This sleeve 1 is composed of an extremely thick cylindrical portion 2 for holding the sleeve on the upper side and an extremely thin cylindrical portion 3 extending from the very thick cylindrical portion 2 to the lower end of the sleeve. The upper half forms a large-diameter cylindrical portion 2a, the lower half forms a small-diameter cylindrical portion 2b, and the sleeve 1 is attached to the outer peripheral surface of the small-diameter cylindrical portion 2b on the apparatus main body side when setting the medicine filling device. A screw 9 is provided for fixing to the screw. The thickness of the ultrathin cylindrical portion 3 is very thin, 0.1 to 1.0 mm. Since the method of using the sleeve 1 has already been described with reference to FIG. 1 in the background art section, the description thereof will be omitted.

  As shown in FIGS. 2 (a) and 2 (b), the sleeve 1 for a medicine filling container has a high hardness layer 10 on the entire inner peripheral surface of the sleeve 1, and a low hardness layer on the outer peripheral surface side of the ultrathin cylindrical portion 3. As shown in FIG. 2 (c), the tip surface of the ultrathin cylindrical portion 3 has a high hardness layer 10 on the inner peripheral side and a low hardness layer 11 on the outer peripheral side. The inner peripheral surface of the sleeve 1 made of the high hardness layer 10 is continuous with the same inner diameter over the entire length of the sleeve 1, but the inlet portion 1o of the sleeve 1 into which the gasket 7 and the pusher 6 are inserted is In order to facilitate the insertion, the taper is widened.

  According to the sleeve 1 configured as described above, since the entire inner peripheral surface of the sleeve 1 is composed of the high hardness layer 10, as shown in FIG. 1, the sleeve 1 is slid and pushed into the cylinder container 4. By repeating the sliding action of the gasket 7, the inner peripheral surface of the sleeve 1 is hardly damaged and the service life of the sleeve 1 can be extended. Further, since the outer peripheral surface side of the ultrathin cylindrical portion 3 is composed of the low hardness layer 11, when the ultrathin cylindrical portion 3 enters the cylinder container 4, the outer peripheral portion of the ultrathin cylindrical portion 3 causes the inner peripheral surface of the cylinder container 4. The life of the cylinder container 4 can be extended.

  Next, the manufacturing method of the said medicine filling container sleeve 1 is demonstrated with reference to (a)-(f) of FIG.

  In manufacturing the sleeve 1, SUS304 and SUS316L were used as the sleeve material. The sleeve 1 manufactured by the following method includes both a sleeve formed of SUS304 and a sleeve formed of SUS316L.

  First, a cylindrical workpiece W (see (1) in FIG. 3) having a predetermined dimension (for example, a length of 115 mm and a diameter of 38 mm) made of the sleeve material is prepared. Then, as shown in (b) of the figure, a hole 12 having a predetermined inner diameter extending through the entire length along the axial center is provided in the cylindrical workpiece W. The hole diameter at this time is a hole diameter that leaves a finishing allowance. For example, if the finish hole diameter is 9.0 mm, and the finishing allowance is 0.2 mm, the inner diameter of the hole 12 is 8.6 mm. After that, the inner peripheral surface of the hole 12 is mirror finished by grinding to obtain a mirror surface with a hole diameter of 9.0 mm.

  Next, as shown in FIG. 3 (c), the lower end portion of the workpiece W (the vertical relationship with respect to FIG. 2 is reversed) is left, for example, by a length of 18 mm so as to form the large-diameter cylindrical portion 2a. The upper side of the large-diameter cylindrical portion 2a is cut so that the outer diameter is, for example, 20 mm over a length of, for example, 20 mm to form the small-diameter cylindrical portion 2b, and the tapered portion 2c is formed. The upper side of the workpiece W is cut so that a machining allowance of 2 mm or more remains in the ultrathin cylindrical portion 3 to form a cylindrical portion 13 for forming the ultrathin cylindrical portion. In this case, if the thickness of the cylindrical portion 13 for forming the ultrathin cylindrical portion is 3 mm, for example, the final finished hole diameter is 9 mm plus 6 mm (thickness 3 mm × 2), and the outer diameter is 15 mm. .

  Then, as shown in FIG. 3 (d), the entire surface of the work W including the inner peripheral surface of the hole 12 is subjected to surface hardening treatment, whereby the entire work W is surface-hardened, and the inner peripheral surface of the hole 12 The high hardness layer 10 of about 0.02 to 0.10 mm is formed on the entire surface of the workpiece W including This surface hardening process will be described later.

  Then, the outer peripheral surface side of the cylindrical portion 13 for forming the ultrathin cylindrical portion of the surface-hardened workpiece W is cut to a predetermined thickness (for example, 0.5 mm), thereby forming the ultrathin cylindrical portion 3. . That is, if the thickness of the cylindrical portion 13 for forming the ultrathin cylindrical portion of the surface-hardened workpiece W is 3.0 mm, the outer periphery of the cylindrical portion 13 for forming the ultrathin cylindrical portion is 0.5 mm until the thickness becomes 0.5 mm. The surface side is scraped off by 2.5 mm (3.0 mm-0.5 mm). A state in which the outer peripheral surface side of the cylindrical portion 13 is scraped is shown in FIG. 3 (e), and a state after scraping is shown in (f).

  As described above, by cutting the outer peripheral surface side of the ultrathin cylindrical portion forming cylindrical portion 13 to a predetermined thickness, for example, 0.5 mm, the ultrathin cylindrical portion 3 having a thickness of 0.5 mm is formed, As a result, the ultrathin cylindrical portion 3 forms a hardened surface layer k having a thickness of about 0.02 to 0.10 mm in the same manner as the inner peripheral surface of the ultrathick cylindrical portion 2 on the inner peripheral surface of the cylindrical portion 3. On the outer peripheral surface side, the surface hardened layer k is removed, and the original hardness (about Hb160) of the material of the workpiece W (SUS304 or SUS316L) is obtained.

  Further, as shown in FIG. 3 (e), the high hardness layer 10 is formed on the upper end surface side of the cylindrical portion 13 only by scraping the outer peripheral surface side of the ultrathin cylindrical portion forming cylindrical portion 13 to a predetermined thickness. Since it remains, the end surface side high hardness layer 10 of this cylindrical part 13 is finally cut off. As a result, as shown in FIG. 2C, the tip surface side of the ultrathin cylindrical portion 3 becomes the high hardness layer 10 on the inner peripheral side and the low hardness layer 11 on the outer peripheral side.

  The manufacturing method as described above facilitates the medicine filling container sleeve 1 in which the entire inner peripheral surface of the medicine filling container sleeve 1 is made of the high hardness layer 10 and the outer peripheral surface side of the ultrathin cylindrical portion 3 is made of the low hardness layer. And can be manufactured with high accuracy.

  In addition, as the surface hardening treatment method in the manufacturing method of the present invention described above, (1). Daido Hokusan's original surface treatment technology, "Pionite treatment", (2). Edison Hard's original "EH treatment" which is a surface treatment technology, (3) "Kanak treatment" which is a unique surface treatment technology of Kanakku Ltd., and (4). "Radical" which is a unique surface treatment technology of JEOL Ltd. Four "nitriding" were tried. Any of these surface hardening treatments requires a treatment temperature of 400 ° C. to 600 ° C. However, in the production method according to the present invention, the workpiece W (SUS304 or SUS304 or Since the processing of SUS316L) is performed, the workpiece W is not deformed even if the processing time is considerably long.

The surface hardening treatment method will be briefly described. “Pionite treatment” is a method in which carbon is dissolved and diffused in the austenite structure in a temperature range of 500 ° C. or less, and a surface hardening degree similar to that of nitriding treatment is obtained. In addition, the wear resistance is remarkably improved, and the hardened layer of the austenite structure has a corrosion resistance superior to that of the untreated material. “EH treatment” is a kind of nitriding treatment method and is a surface hardening method using a thermal decomposition reaction of lime nitrogen mainly composed of CaCN ₂ and using this powder as a nitriding medium. “Kanak treatment” is a kind of vacuum nitriding treatment method. A nitriding promotion gas mainly composed of NH ₃ is sent into the furnace in a vacuum and contains a sustaining agent, a nitrogen generator, and an anti-adhesive agent. This is a treatment method in which the active material diffuses into the base material. Furthermore, “radical nitridation” is a plasma surface modification method that efficiently uses nitriding radicals (active species) obtained by controlling gas flow rate, processing pressure, plasma output, etc. with high precision. This is the processing method to be performed.

  The test results of the surface hardness and the corrosion resistance of the SUS304 and SUS316L chemical-filled container sleeve 1 manufactured by the above-described manufacturing method are compared in the case of the above four types of surface hardening treatments. And Table-2.

尚、耐食性試験では、塩酸（濃度３０．５％、温度３０℃）を使用した。
(Table-1)
For SUS304

In the corrosion resistance test, hydrochloric acid (concentration 30.5%, temperature 30 ° C.) was used.

尚、耐食性試験では、塩酸（濃度３０．５％、温度３０℃）を使用した。
(Table-2)
For SUS316L

In the corrosion resistance test, hydrochloric acid (concentration 30.5%, temperature 30 ° C.) was used.

  From the test results shown in Tables 1 and 2 above, there is no problem with wear against powdered chemicals as long as the surface hardness is Hv 700 or higher for any material of SUS304 and SUS316L. As for corrosion resistance, it was found that the one by the pionite treatment was the best.

It is explanatory sectional drawing explaining the usage method of the sleeve for chemical | medical agent filling containers which concerns on this invention. (a) is a cross-sectional enlarged front view of the sleeve for a medicine filling container shown in FIG. 1, (b) is a partially enlarged cross-sectional view of the sleeve, and (c) is an enlarged view of a portion indicated by an arrow X in (b). (a)-(f) is explanatory drawing explaining the manufacturing method of the sleeve for chemical | medical agent filling containers which concerns on this invention.

Explanation of symbols

DESCRIPTION OF SYMBOLS 1 Sleeve for chemical filling containers 2 Extremely thick cylindrical part 3 Ultrathin cylindrical part 4 Cylinder container 5 Medicinal powder or liquid 6 Pusher 7 Gasket 10 High hardness layer 11 Low hardness layer 12 Hole 13 Ultrathin cylindrical part forming cylindrical part W Workpiece

Claims (3)

A sleeve for a medicine-filled container made of a metal material having excellent corrosion resistance for pushing a gasket for sealing a container into a cylinder container filled with medicinal powder or liquid, through an opening at the upper end of the cylinder container. In the sleeve for a medicine filling container consisting of a very thick cylindrical portion for holding and an extremely thin cylindrical portion extending from the very thick cylindrical portion to the lower end of the sleeve,
A sleeve for a medicine-filled container, wherein the entire inner peripheral surface of the sleeve is made of a high hardness layer, and the outer peripheral surface side of the ultrathin cylindrical portion is made of a low hardness layer.   A cylindrical work piece of a predetermined length made of a metal material having excellent corrosion resistance is provided with a hole having a predetermined inner diameter extending along the axial center and finishing the inner peripheral surface of the hole. The entire surface of the workpiece including the peripheral surface is subjected to surface hardening treatment, and the outer peripheral surface side of the cylindrical portion for forming the ultra-thin cylindrical portion extending from the one end of the surface-hardened workpiece to a predetermined length is cut to add a pole having a predetermined thickness. 2. The method for manufacturing a sleeve for a medicine-filled container according to claim 1, wherein a thin cylindrical portion is formed. The outer peripheral surface side of the cylindrical portion for forming the ultrathin cylindrical portion over a predetermined length from one end of the surface hardened workpiece is cut to form an ultrathin cylindrical portion with a predetermined thickness, and the surface hardening of the one end surface side of the workpiece is performed. The method for producing a sleeve for a medicine-filled container according to claim 2, wherein the portion is excised.

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