JP2007050339A - Organic synthesis apparatus - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To provide an organic synthesis apparatus, wherein stable rotation of low speed to high speed is available without being affected by an adjacent magnet, the number of revolution can be set separately, and the reaction condition of one reaction vessel and that of other reaction vessels can be set simultaneously while they are easily made equal. <P>SOLUTION: The organic synthesis apparatus is provided with: a reaction vessel grasping part capable of grasping two or more reaction vessels; and two or more agitation means 28 each of which is used for agitating a reagent in the grasped reaction vessel by moving a stirring chip due to displacement of a magnetic field, wherein a magnetic field isolating means 44 for preventing the displacement of the magnetic field of one of the adjacent agitation means 28 from affecting the magnetic field of the other of the adjacent agitation means 28 is further arranged, and a control means is constituted so that the reaction condition can be set for each of reaction vessels to be grasped by the reaction vessel grasping part, and the reaction condition set for each reaction vessel can be synchronized with that set for respective other reaction vessels. <P>COPYRIGHT: (C)2007,JPO&INPIT

Description

    The present invention relates to an organic synthesizer that synthesizes a reagent contained in a reaction vessel by stirring and heating the reagent in the reaction vessel.

    Conventionally, an organic synthesizer has been used as one that synthesizes many types of reagents under the same conditions or different conditions at one time, and tests the synthesized reagents all at once. This organic synthesizer synthesizes the reagent accommodated in the reaction container by stirring and heating the reagent in the reaction container. For example, as shown in FIG. 8, the organic synthesizer includes a reaction container gripper 72 that can grip five reaction containers 70 and a stirring unit that stirs the reagent in the reaction container 70 gripped by the reaction container gripper 72. 74 and a reagent addition unit 76 attached to the opening of the reaction container 70 and capable of adding a reagent into the reaction container 70 (see Patent Document 1).

  In the conventional organic synthesizer, the reaction vessel gripping portion 72 and the stirring portion 74 can be separated, and the reagent addition portion 76 is attached to the opening at the upper end of the reaction vessel 70 held by the reaction vessel gripping portion 72. It is configured. The stirring unit 74 includes a heating unit having a heater that heats the lower portion of the reaction vessel 70. The reaction container gripping portion 72 is provided for each of the top plate 78 in which a hole that can protrude from the top of the gripped reaction vessel 70 is formed, and the reaction container 70 gripped below the top plate 78. A holding block 84 having an insertion hole into which the bottom of the tube can be inserted, and a reflux block provided for each reaction vessel 70 gripped between the top plate 78 and the holding unit 84 and having a through-hole through which the reaction vessel 70 can pass. 82, a recirculation block 82, and a support column 86 that holds the holding portion 84 against the top plate 78. The heater of the stirring unit 74 is provided at a position aligned with each holding unit 84 of the reaction vessel gripping unit 72. Therefore, heat is transmitted from the heater of the heating unit to the lower side of the reaction vessel 70 via the holding unit 84. When the lower part of the reaction vessel 70 is heated by the heater of this heating unit, the reagent filled in the reaction vessel 70 evaporates, but it is cooled and condensed at the position of the reflux block 82 of the reaction vessel 70, and becomes a gas again. It is configured to be returned.

  The stirring unit 74 is provided with a reagent in the reaction vessel 70 and is provided with a rotating magnet that rotates a rotating tip composed of a magnet for each reaction vessel 70 held by the reaction vessel holding unit 72. The reagent in the reaction vessel 70 is agitated by rotating the rotating tip in the reaction vessel 70. FIG. 9 is a conceptual diagram showing the drive configuration of these rotating magnets. As shown in FIG. 9, the rotary magnets 88 </ b> A to 88 </ b> E have a single drive belt 92 attached to a drive pulley 90 connected to a drive source such as a motor. It is configured to rotate.

JP 11-137990 A

  As described above, in the conventional organic synthesizer, the rotating magnets 88A to 88E of the stirring unit are configured to be rotated by a single motor. Therefore, the stirring speed of all the reaction containers must be the same. There is a request to change the stirring speed every time. In order to meet this requirement, it is conceivable to provide a motor for each rotating magnetic force. However, since these rotating magnets 88A to 88E are provided in parallel for each of the gripped reaction vessels 70, adjacent rotating magnets are provided. There is a problem that the magnetic force between each other affects each other and the stirring speed cannot be easily adjusted. For example, even when rotating at a low speed, there is a problem that if an adjacent magnet rotates at a high speed, the magnet rotates at a high speed.

  In addition, the conventional organic synthesizer needs to set the reaction conditions for each reaction container even when the reaction conditions such as the reaction temperature of one reaction container are the same as those of the other reaction containers. There is a problem that the setting work is complicated.

  Therefore, the present invention provides an organic synthesizer capable of obtaining stable rotation from low-speed rotation to high-speed rotation without being influenced by adjacent magnets, and capable of easily setting the number of rotations individually. The first purpose. The second object of the present invention is to provide an organic synthesizer capable of easily setting the reaction conditions of one reaction vessel to be the same as those of other reaction vessels.

  In order to achieve the first object, the present invention is provided at each position where the reaction container gripping part capable of gripping two or more reaction containers and the reaction container gripped by the reaction container gripping part are aligned. And two or more agitation means for agitating the reagent in the grasped reaction container by moving the chip accommodated with the reagent in the grasped reaction container by the displacement of the magnetic field. The apparatus further includes magnetic field blocking means for preventing displacement of one magnetic field of the two or more adjacent stirring means from affecting the magnetic field of the other stirring means.

  Thus, according to the organic synthesizing apparatus according to the present invention, since the displacement of one magnetic field of the adjacent stirring means is provided with the magnetic field blocking means for preventing the magnetic field of the other stirring means from being affected, Each stirring speed can be easily adjusted without being influenced by the displacement of the magnetic field of the stirring means. In the organic synthesizer according to the present invention, it is preferable that the magnetic field blocking means is formed in a ring shape surrounding a portion of the stirring means where the magnetic field is displaced.

  In order to achieve the second object, the present invention provides a reaction container gripping part capable of gripping two or more reaction containers, a heating means for heating the inside of the reaction container gripped by the reaction container gripping part, An organic synthesizer comprising: stirring means for stirring the reagent in the reaction container gripped by the reaction container gripping section; and control means for controlling at least the heating means and the stirring means, wherein the control means includes: The reaction conditions can be set for each reaction container gripped by the reaction container gripping unit, and the reaction conditions set in each reaction container are synchronized with the reaction conditions set in the other reaction containers, respectively. Is configured to be possible.

  As described above, according to the organic synthesizer according to the present invention, the reaction conditions set in each reaction vessel can be synchronized with the reaction conditions set in the other reaction vessels. It is possible to easily set the reaction conditions of the reaction container as those of the other reaction containers.

  As described above, according to the organic synthesizer according to the present invention, a stable rotation from a low rotation to a high rotation can be obtained without being affected by adjacent magnets, and the number of rotations can be individually set. Since it is configured to be able to synchronize with the reaction conditions set in other reaction vessels, it is easy to set the reaction conditions in one reaction vessel to be the same as those in other reaction vessels. An apparatus can be provided.

  Next, examples of the organic synthesis apparatus according to the present invention will be described with reference to the drawings. FIG. 1 is a conceptual front view showing a use state of the organic synthesis apparatus according to the present embodiment. The organic synthesizer according to the present embodiment includes a reaction container gripping part 10 that can grip four reaction containers 8 and a stirring part 12 that stirs the reagent in the reaction container 8 gripped by the reaction container gripping part 10. The reaction container holding part 10 and the stirring part 12 are configured to be separable.

  The reaction container gripping part 10 is provided for each reaction container 8, and is a frame that supports the four reaction container holders 14, the four reagent addition parts 16, and the four reaction container holders 14 connected to the reaction containers 8. 18. The reaction vessel holder 14 includes four top plates 20 and four reflux blocks 22 that are provided below the top plate 20 and cool the substances evaporated in the reaction vessel 8 to return them to liquid again. The top plate 20 and the reflux block 22 are provided with through holes so that the reagent addition portion can be inserted and aligned. Further, fixing screws 20 a that fix the top plate 20 to the frame body 18 are provided at the front and rear edges of the top plate 20. In addition, on the upper surface of the frame body 18, a grip portion 18 a that can grip the frame body 18 is provided.

  As shown in FIGS. 1 to 3, the stirring unit 12 is disposed in the housing 24, the heating units 26 a to 26 d that are disposed on the upper surface of the housing 24, and heats the lower portions of the reaction vessels 8, and the reaction vessels 8. A rotating magnet unit 28 that rotates the rotating chip and a control unit 30 (see FIG. 5) that controls reaction conditions are provided.

  Each heating part 26a thru | or 26d is provided for every reaction container 8 hold | gripped by the reaction container holding part 10, and the heating temperature is comprised so that each can be set separately so that it may mention later. Each of the heating units 26a to 26d has an insertion hole that can be inserted while the reaction vessel 8 is in close contact, and is configured to heat the reaction vessel 8 inserted into the insertion hole by a heater (not shown). ing.

  Each rotating magnet unit 28 is provided for each reaction vessel 8 gripped by the reaction vessel gripping unit 10, and includes a disk-shaped rotating disk 32 and a pair of positions provided at opposing positions on the rotating disk 32. And magnets 34 and 34. These magnets 34 and 34 are provided so that “N” and “S” are opposite to each other. Below each of these turntables 32, motors 36a to 36d for rotating the turntable 32 are provided. The upper surfaces of the main bodies of the motors 36a to 36d are fixed to the bottom surface side of a fixing plate 38 provided in the housing 24, and the shaft centers of the motors 36a to 36d pass through holes formed in the fixing plate 38. , And joined to the center of the rotating plate 32 positioned above the fixed plate 38. The fixed plate 38 is supported by pillars 42 provided at the four corners of the fixed plate 38 via a vibration isolator 40 made of an elastic member such as rubber.

  In the present embodiment, on the fixed plate 38, a ring-shaped magnetic field blocking member 44 is provided for each rotary magnet unit 28 via a fixed member 46 so as to surround the outer periphery of the rotary magnet unit 28. The magnetic field blocking section 44 is made of a material that absorbs magnetism, such as iron, and preferably has a height that is at least higher than the height of the rotating magnet section 28.

  In the present embodiment, the rotating magnet unit 28 is provided in parallel as in the conventional organic synthesis apparatus, but since the magnetic field blocking member 44 is provided for each rotating magnet unit 28, other adjacent rotations are provided. There is no influence of the magnet portion 28. Accordingly, when the rotary magnet unit 28 is rotated by driving the motors 36a to 36d, the rotary chip placed in each reaction vessel 8 together with the reagent rotates to stir the solution in the reaction vessel 8, but the magnetic field blocking member 44 prevents the influence of the adjacent magnetic flux, so even if the rotational speed is different from that of the adjacent rotating magnet part 28, the rotation of the adjacent rotating magnet part 28 is not affected and provides stable rotation. can do.

As shown in FIGS. 1 and 5, the control unit 30 includes a first control unit 30a to a fourth control unit 30d that control the reaction conditions of the reaction vessel 8 held by the reaction vessel holding unit 10, and the first control unit 30a. And a fifth control unit 30e that controls the control unit 30a to the fourth control unit 30d. The first control unit 30a to the fourth control unit 30d and the fifth control unit 30e are connected by a bus 48 so that signals can be transmitted and received. The first control unit 30a controls the rotational speed of the motor 44a based on the first input unit 50a that inputs control information, the first display unit 52a that displays the input information and measurement information such as temperature, and the like. The first rotation control unit 54a, the first temperature control unit 56a for controlling the heating temperature of the heating unit 26a, and the first synchronization control unit 58a, and the reaction conditions input by the first input unit 50a Based on the above, the number of rotations of the motor 44a and the heating temperature of the heating unit 26a are controlled. Similar to the first control unit 30a, the second control unit 30b to the fourth control unit 30d are the second to fourth input units 50b to 50d, the second to fourth display units 52b to 52d, and the second to fourth units. Four rotation control units 54b to 54d, second to fourth temperature control units 56b to 56d, and second to fourth synchronization control units 58b to 58d are provided. The fifth control unit 30e includes a fifth input unit 50e, a fifth display unit 52e, and a synchronization control unit 58e. The first to fifth synchronization control units 58b to 58e cause one of the first to fourth control units 30a to 30d to function as a main control unit according to the input of the fifth input unit 50e, and It is comprised so that it may function as a sub-control part synchronizing with the reaction conditions of a main control part. Here, to synchronize the reaction conditions is to set the setting conditions of the first to fourth rotation control units 54a to 54d and the setting conditions of the first to fourth temperature control units 56a to 56d to be the same. The fifth control unit 30e may be, for example, a personal computer connected to an external terminal of the organic synthesis apparatus. Further, the fifth control unit 30e is omitted, and only the first control unit 30a to the fourth control unit 30d are configured to function synchronously based on the inputs of the first to fourth input units 50a to 50d. Good.

  Next, control by the first to fifth synchronization controllers 58a to 58e will be described with reference to FIG. First, in FIG. 6A, synchronization information is input from the fifth input unit 50e, and the first control unit 30a functions as a main control unit (symbol, main) capable of setting reaction conditions independently. It sets so that it may function as a sub-control part (code | symbol, sub) which synchronizes the reaction conditions of the 2nd and 3rd control parts 30b and 30c with the reaction conditions of the 1st control part 38a which is a main control part. Next, in FIG. 6B, when control information for controlling the first control unit 30a to a constant temperature of 25 ° C. and the fourth control unit 30d to 30 ° C. is input from the first and fourth input units 50a and 50d, As shown in FIG. 6C, the second and third control units 30b and 30c are set to 25 ° C. in synchronization with the set temperature of the first control unit 30a without receiving the set temperature. In FIG. 6, only the synchronization of the temperature setting is illustrated, but the synchronization of the stirring speed and the reaction time may be set similarly.

Although the embodiments of the invention have been described above, the present invention is not limited to these embodiments, and various modifications, additions, substitutions, and the like can be made without departing from the spirit of the invention. For example, the reaction container gripping part 10 of the organic synthesizer and the corresponding first to fourth control parts 30a to 30d are not limited to four, and may be five or more, and the larger the number, When the user sets the reaction conditions to be the same, the user can quickly use the organic synthesis apparatus without performing complicated setting work. Further, the magnetic field blocking member 44 described above may have a double structure as shown in FIG. 7 instead of the single structure shown in FIGS. Further, in the above embodiment, the magnetic field blocking member 44 is provided for each rotating magnet unit 28. However, since it is only necessary to block the influence of the magnetic field from the adjacent rotating magnet unit 28, every other magnetic field blocking member 44 is provided. It may be provided. Furthermore, the magnetic field blocking member 44 may be configured to block the magnetic field between adjacent magnets 34 instead of a ring-shaped structure, and may have a plate shape provided between the rotating disks 32. is there.

It is a disassembled perspective view of the organic synthesizer concerning one example of the present invention, and a front view at the time of use. It is A-A 'sectional drawing concerning FIG. 1 of the stirring part 12 of the organic synthesis apparatus which concerns on a present Example. It is B-B 'sectional drawing concerning FIG. 2 of the stirring part 12 of the organic synthesis apparatus which concerns on a present Example. It is the C section expansion perspective view of FIG. It is a functional block diagram of the organic synthesis apparatus which concerns on a present Example. It is a figure which shows the example of control of the organic synthesis apparatus which concerns on a present Example. It is an expansion perspective view of the rotation magnet part of the organic synthesizer concerning other examples of the present invention. It is a front conceptual diagram which shows the conventional organic synthesizer. It is a conceptual diagram which shows arrangement | positioning of the rotating magnet of the stirring part of the conventional organic synthesizer.

Explanation of symbols

DESCRIPTION OF SYMBOLS 8 ... Reaction container, 10 ... Reaction container holding part, 12 ... Stirring part, 14 ... Reaction container holder, 16 ... Reagent addition part, 18 ... Frame, 18a ... Holding part, 20 ... Top plate, 20a ... Fixing screw, 22 Reflux block, 24 housing, 26 heating unit, 28 rotating magnet unit, 30 control unit, 32 rotating plate, 34 magnet, 36 motor, 38 fixed plate, 40 vibration isolating unit, 42 ... Pole, 44 ... magnetic field blocking member, 46 ... fixing member, 48 ... bus, 50 ... input unit, 52 ... display unit, 54 ... rotation control unit, 56 ... temperature control unit, 58 ... synchronization control unit

Claims (3)

A reaction container gripping part capable of gripping two or more reaction containers;
It is provided at each position aligned with the reaction vessel held by the reaction vessel holding portion, and is held by moving the chip accommodated together with the reagent in the held reaction vessel by displacement of the magnetic field. In an organic synthesizer comprising two or more stirring means for stirring the reagent in the reaction vessel,
An organic synthesizing apparatus, further comprising a magnetic field blocking means for preventing a displacement of one magnetic field of the two or more adjacent stirring means from affecting the magnetic field of the other stirring means.        2. The organic synthesizer according to claim 1, wherein the magnetic field blocking means is formed in a ring shape surrounding a portion of the stirring means where the magnetic field is displaced. A reaction container gripping part capable of gripping two or more reaction containers;
Heating means for heating the inside of the reaction vessel held by the reaction vessel holding unit;
Stirring means for stirring the reagent in the reaction container held by the reaction container holding part;
A control means for controlling at least the heating means and the stirring means, and an organic synthesis apparatus comprising:
The control means is configured to be able to set reaction conditions for each reaction container gripped by the reaction container gripping part,
An organic synthesizer characterized in that reaction conditions set in each reaction vessel can be synchronized with reaction conditions set in other reaction vessels, respectively.

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