JP2007000543A - Biological component measuring probe supporter and biological component measuring device using the same - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To provide a biological component measuring probe supporter capable of obtaining the time-based reproducibility of a biological spectrum and improving the quantitative accuracy in the biological component concentration. <P>SOLUTION: An arm fixer 11 designed to be fitted on an arm 9 of a subject by means of a belt 14 has a penetration hole 16 for guiding a measuring probe 8 to the surface of the arm 9. Since an arm support 3 and a probe support 2 which holds the probe 8 in a way that the probe 8 can be moved up and down are both fixed on a base body 1, their relative positions are kept unchanged. The arm support 3 is provided with a recess part 12b at the top, where the recess part 12b is detachably engaged with a projection part 12a provided at the bottom of the arm fixer 11, so that the relative position between the arm fixer 11 and the arm support 3 can be set in place. <P>COPYRIGHT: (C)2007,JPO&INPIT

Description

  The present invention relates to a biological signal measuring device that irradiates near-infrared light on the surface of a living body, receives reflected light from the living body, and measures a biological signal from the received light component, thereby measuring a biological component in a non-invasive manner. The present invention relates to an in-vivo component measuring probe support used in a living body and an in-vivo component measuring device using the same.

  In vivo component measurement that measures non-invasive in vivo components, such as blood glucose levels, by irradiating near-infrared light on the surface of the living body and receiving reflected light from the living body and measuring biological signals from the received light component An apparatus is provided (for example, Patent Document 1).

  According to this in-vivo component measuring apparatus, there is no need to collect blood from the subject, and there is an advantage that blood glucose level can be measured without imposing a heavy burden on the subject.

  By the way, in the in-vivo component measuring apparatus as disclosed in Patent Document 1, the irradiation light varies depending on the ambient temperature variation or the positional relationship of the optical components, and the reflected light spectrum is measured. In order to correct this variation, the reference light reflected from a reference plate such as a ceramic plate is measured, and this is used as the reference light for ambient temperature. And variations due to the positional relationship of optical components are corrected.

On the other hand, when the spectrum is continuously measured, in addition to the above-described device-side variation factors, there are also variation factors in the relationship between the measurement probe and the skin. In other words, the surface of the skin has skin grooves / cutaneous skin composed of stratum corneum and forms an uneven shape. When a measurement probe is brought into contact with this surface, there is an air layer, sebum, sweat, etc. between the surface of the probe due to the three-dimensional shape of the skin, and the refractive index of light changes, so the spectral shape and size change. There is a problem of end up.
In other words, the refractive index of light changes due to the presence of an air layer, etc., and the index indicating the spectrum baseline (absorbance value at 1655 nm) varies greatly, or the index indicating the difference in height from the baseline of the water spectrum (1449 nm The difference between the absorbance value and the 1655 nm absorbance value) suddenly increases.

Therefore, in the device disclosed in Patent Document 1, in order to reduce the phenomenon as much as possible, a probe for measurement at a predetermined pressure by the urging means in a state where the arm of the subject is supported by a living body support unit capable of adjusting the angle. To the test subject's arm (skin), increasing the contact area of the probe for measurement to the dermis, that is, increasing adhesion, reducing the influence of the probe for measurement and the skin surface as much as possible, and reducing spectral fluctuations. It was supposed to be measured with restraint. In this case, a probe cradle for guiding the measurement probe to a position where it is brought into contact is attached and fixed to the arm with an adhesive tape, or is fixed to the arm with a belt.
Japanese Patent Laid-Open No. 2003-310578 (paragraph numbers 0057 and 0063, FIG. 1)

  Even if the adhesion is ensured by bringing the measurement probe into contact with a predetermined pressure by urging by the urging means as in the device disclosed in Patent Document 1 described above, the arm is placed on the living body support portion. The body around the measuring part including the wrist is easy to move because it is only placed on the living body support part or holding the grip bar, so the shape of the part supporting the skin such as muscle and tendon is As a result, the probe cradle follows the shape change, so that there is a problem that the position of the probe for measurement is deviated, and the index of the spectrum fluctuates even if it is a minute deviation of about 200 μm.

  In other words, the dermis layer in which near-infrared light enters the skin and picks up a lot of biological information absorbs moisture such as ISF (interstitial fluid) that fills between the fibrous structures of collagenous fibrous materials. There is plenty of substrate, and it is very easy to move by pressurization. This substrate contains a large amount of biological information-related substances such as glucose that permeates from capillaries, which greatly affects the shape of the spectrum. In addition, collagen and other binding fibers are densely arranged in a mesh, and the mesh layer that plays an important role in controlling skin movement is also a substance present in the optical path. The optical path depends on the probe contact position and probe contact angle. There are subtle changes, which have a great influence on the shape of the spectrum.

  Regardless of changes in the concentration of components in the body, if the measurement process varies or changes over time, the accuracy of quantification is low when quantifying component concentrations in multivariate analysis using these spectra. There was a problem of becoming.

  The present invention has been made in view of the above points, and provides a probe support for measuring in vivo components that can obtain the reproducibility of the biological spectrum over time and increase the quantitative accuracy of the concentration of biological components, and the probe support An object of the present invention is to provide an in-vivo component measuring apparatus using the above.

  In order to achieve the above-mentioned object, in the invention of the probe support for measuring in vivo components according to claim 1, the arm having a means for mounting on the arm of the subject and a through-hole for guiding the probe for measurement on the surface of the arm A fixed body; a probe support that defines a reference position of the probe; and an arm mount on which the position of the probe support is fixed; and a positional relationship between the arm mount and the arm fixed body It has the positioning part which detachably defines.

  According to the invention of the probe support for measuring the in vivo component of the first aspect, when measuring the in vivo component, the positional relationship of the arm fixing body mounted on the arm of the subject with respect to the arm rest is determined by the positioning unit. The movement of the arm during the measurement can be defined, so that the probe supported by the probe support whose position with the arm rest is fixed to the arm of the subject through the through hole of the arm fixed body Since the position to be pressed is stable and accurate, and the arm fixing body can be removed from the armrest while it is attached to the arm, the subject must be able to measure between measurements. It is possible to perform other activities while wearing the arm fixing body, and when the measurement is performed again, the positioning unit can accurately position the position of the arm rest and the arm fixing body in the previous measurement state. A living subject It is possible to reduce the change in the contact pressure and contact position of the probe for measurement with the arm of each measurement, and as a result, obtain the reproducibility of the biological spectrum over time and increase the quantification accuracy of the concentration of biological components. To do.

  According to a second aspect of the present invention, the positioning part is formed by a pair of non-circular uneven parts fitted to each other. To do.

  According to the invention of the probe support for measuring in-vivo components according to claim 2, since the positioning portion performs positioning by fitting one concavo-convex portion, positioning of the arm rest and the arm fixing body is performed. Since it can be easily performed and the uneven portion is non-circular, positional displacement due to rotation does not occur, so that the positioning state can be maintained.

  According to a third aspect of the present invention, the positioning unit locks the arm rest and the arm fixing body, and the arm rest and the arm support. A lock mechanism is provided for releasing the lock when a force of a predetermined value or more is applied in a direction in which the arm fixing body is pulled apart.

  According to the invention of the probe support for measuring in-vivo components of claim 3, the positioned state can be maintained with high accuracy, and the lock can be easily released.

  According to a fourth aspect of the present invention, there is provided the probe support for in vivo component measurement according to any one of the first to third aspects, further comprising a grip portion for defining a wrist angle with an arm placed on the arm rest. It is characterized by that.

  According to the invention of the probe support for measuring in vivo components according to claim 4, by specifying the wrist angle, the state of the arm muscles near the position where the probe guided by the through hole of the arm fixing body is pressed is also provided. It can be reproduced and more accurate measurement can be performed.

  In the in-vivo component measuring device according to the fifth aspect, the in-vivo component measuring probe support according to any one of claims 1 to 4 and the measuring probe mounted on the in-vivo component measuring probe support. A light source that transmits near-infrared light via a measurement optical fiber and a light-receiving optical fiber having one end connected to the probe, and receives reflected light emitted from the other end via optical means. It is characterized by comprising a light receiving element and an arithmetic device for calculating a component in the living body by analyzing a spectrum which is a biological signal included in the reflected light received by the light receiving element.

  According to the in-vivo component measuring apparatus of claim 5, the in-vivo component measurement can reduce the change in the contact pressure, the contact position, etc. of the measurement probe with respect to the arm of the subject who is a living body every measurement. By using the probe support tool, it is possible to obtain biological spectrum reproducibility over time and perform measurement with high quantification accuracy of biological component concentration.

  The present invention can determine the movement of the arm during measurement by determining the positional relationship with respect to the arm rest of the arm fixing body attached to the arm of the subject when measuring the in vivo component, Therefore, the position where the probe supported by the probe support with its position fixed to the arm rest is pressed against the arm of the subject through the through hole of the arm fixing body can be measured stably and accurately. Since the arm fixing body can be removed from the arm stand while wearing on the arm, the subject may perform other activities while wearing the arm fixing body between measurements when performing regular measurements. In addition, when the measurement is performed again, the positioning unit can accurately position the positional relationship between the arm rest and the arm fixed body in the state of the previous measurement, so that the contact pressure of the measurement probe against the arm of the subject who is a living body Or contact It reduces the like location is changed for each measurement, the results obtained over time reproducibility of the biological spectrum, it is possible to improve the quantitative accuracy of the biological constituent concentration.

  Embodiments of the present invention will be described below.

(Embodiment 1)
In this embodiment, as shown in FIG. 1A, a probe support 2 is vertically fixed on a base body 1 of a support, and an arm rest is placed on the base body 1 so as to be parallel to the probe support 2. 3 is fixedly arranged, and the position of the arm rest 3 with respect to the probe support 2 is fixed via the base body 1.

  The probe support body 2 includes an interlocking portion (not shown) that converts the rotation of the manual operation portion 4 provided in the upper end portion in the left-right direction into a linear motion, and moves the movable body 5 that moves up and down by the interlocking portion to the armrest. It is exposed on the side surface on the 3rd side.

  The moving body 5 fixes and supports a probe fixture 7 via a load cell 6 for pressure detection, and a measurement probe 8 fixed to the end of the probe fixture 7 located above the arm rest 3. It can be moved in the direction of the arm rest 3 or moved away from the arm rest 3.

  The load cell 6 is for detecting the force when the tip of the probe 8 is pressed against the arm 9 of the subject, and the arm of the probe 8 is operated by operating the manual operation unit 4 based on the detected pressure of the load cell 6. The pressing force to 9 can be made constant.

  The probe 8 has a light emitting fiber for sending near-infrared light to be irradiated on the skin surface of the arm 9 for measurement from the light source and light reflected in the living body and sends it to the apparatus side at the upper end. One end of an optical fiber 10 composed of a light receiving fiber is introduced.

  The arm rest 3 is a flat base having a rectangular planar shape as shown in FIG. 1B, and the longitudinal direction is perpendicular to the cross section of the arm 9 shown in FIG. It is fixed on the base body 1 so as to become, and at the center part thereof, there is provided a concave section 12b having a quadrangular cross section that can be detachably fitted with a convex section 12a having a quadrangular section on the side of the arm fixing body 11 described later. The pair of concave portions 12b and convex portions 12a constitute a positioning portion that determines the positional relationship of the arm fixing body 11 with respect to the arm rest 3. In addition, the cross-sectional shape of the convex part 12a and the recessed part 12b should just be a non-circular shape which cannot rotate, and may be elliptical besides polygons, such as a rectangle.

  As shown in FIG. 2A, the arm fixing body 11 includes an upper body 3a in which a concave portion 13 having a substantially semicircular cross section is formed on the lower surface that is easy to be in close contact with the inner surface of the subject's arm 10, and the upper body 3a. And a lower body 11b for sandwiching the arm 9 and an attachment belt 14 as means for attaching to the arm 9. The attachment belt 14 has one end fixed to one side surface of the upper body 11a, one end fixed to the other side surface of the belt body 14a and the other side surface of the upper body 11a, and one end fixed to the other side. It consists of a belt segment 14b provided with a fastening fitting 15.

  The upper body 11a is provided with a through hole 16 for guiding the probe 8 in the vertical direction, and the above-mentioned convex portion 12a is projected from the lower surface of the lower body 11b as shown in FIG. .

  Thus, when measuring an in vivo component by an in vivo component measuring apparatus (to be described later) using the in vivo component measuring probe support of the present embodiment, the arm is fixed in a state removed from the in vivo component measuring probe support. The body 11 is worn on the arm 9 of the subject. In this case, the arm 9 of the subject is inserted between the upper body 11a and the lower body 11b of the arm fixing body 11, the inner surface of the arm 9 is fitted into the concave 3 on the lower surface of the upper body 11a, and the lower body 11b. As shown in FIGS. 3 (a) and 3 (b), the attachment belt 14 is fastened to the upper surface of the arm 9 with an elastic body such as a pad 17 (see FIG. 1 (a)) pressed against the outer surface of the arm 9. The arm fixing body 11 is attached to the arm 9.

  Here, the position of the arm 9 for fixing the arm fixing body 11 is made to correspond to the position for measurement of the living body. From the viewpoint of good stability of the surface state and ease of measurement, it is better to set the central region of the forearm inner portion in the arm direction.

  When the attachment of the arm fixing member 11 to the arm 9 of the subject is completed, the convex portion 12a on the lower surface of the arm fixing member 11 is attached to and detached from the concave portion 12b on the upper surface of the arm rest 3 in order to measure the in vivo components. Fit freely. As a result, the arm fixing body 11 is positioned with respect to the arm rest 3. Since this positioning is performed by fitting the concave portion 12b and the convex portion 12a having a quadrangular section, the arm fixing body 11 cannot rotate, and therefore the positioning state is maintained without being affected by the movement of the arm 9 or the like.

  In a state where the arm fixing body 11 is positioned with respect to the arm mounting base 3, the positional relationship between the probe 8 supported by the probe support 2 and the arm fixing body 11 is also via the arm mounting base 3 and the probe support 2. Therefore, when the manual operation unit 4 is rotated and the probe 8 is moved downward, the probe 8 enters the through-hole 16 of the arm fixing body 11 and is guided to the through-hole 16 while being guided by the through-hole 16. The tip is brought into contact with the skin at the measurement position of the arm 9. The probe 8 is adjusted while moving up and down based on the detected pressure of the load cell 6 so that the contact pressure at this time becomes a pressure within a predetermined range that can be measured while keeping the S / N ratio of the biological signal high. Of course, it is assumed that a means for displaying that the detected pressure of the load cell 6 is within a predetermined range is provided on the in-vivo component measuring device side.

  When the probe 8 is thus brought into contact with the measurement position of the arm 9 with a predetermined pressure, the in-vivo component can be measured.

  Then, after the measurement is completed, when the manual operation unit 4 is rotated and the probe 8 is moved so that the tip thereof is positioned above the through hole 16 of the arm fixing body 11, the test subject protrudes from the arm fixing body 11. This is possible by moving the arm 9 so that 12a is disengaged from the recess 12b of the arm rest 3. Therefore, another activity can be performed until the next measurement with the arm fixing body 11 attached to the arm 9. When performing the measurement again, as described above, the convex portion 12a of the arm fixing body 11 is fitted into the concave portion 12b of the arm mounting base 3, and the arm fixing body 11 is positioned with respect to the arm mounting base 3, and then the above described. If the probe 8 is moved downward and brought into contact with the arm 9 with a contact pressure within a predetermined range, in-vivo measurement at the same measurement position can be performed.

In this embodiment, the probe fixture 7 is moved up and down by rotating the manual operation unit 4. However, the stepping motor is used to automatically control the movement of the probe 8 based on the detected pressure of the load cell 6. You may make it do.
(Embodiment 2)
In the first embodiment, the arm rest 3 is directly arranged and fixed on the base body 1, but in the present embodiment, as shown in FIG. 4A, the upper arm of the support body 30 erected on the base body 1 is used. 4 (b) and 4 (c), a recess 3a that is rotatably fitted to a cylindrical shaft portion 30a provided is provided on the lower surface of the arm rest 3, and the arm rest 3 is the upper end of the support 30. The arm rest 3 is pivotably attached to the arm 30 so that the arm rest 3 can be rotated around the shaft 30a so that the tilt angle can be adjusted. As shown in FIG. The state after the adjustment of the tilt angle can be fixed by tightening the angle adjusting knob 31 for screwing the tip portion into the screw hole 30b on the side surface of the shaft portion 30a in the recess 3a.

  That is, in the present embodiment, the tilt angle of the arm rest 3 can be adjusted to the angle at which the arm 6 is easy.

Since other configurations and operations are the same as those of the first embodiment, the same components are denoted by the same reference numerals and description thereof is omitted.
(Embodiment 3)
In this embodiment, instead of a drive unit that moves the probe fixture 7 up and down by rotating the manual operation unit, an auto Z-axis stage 40 with a stepping motor is provided on the side surface of the probe support 2 as shown in FIG. The probe fixing tool 7 is attached to the moving body 5 ′ of the auto Z-axis stage 40, and the rotation of the stepping motor is controlled so that the contact pressure of the probe 8 is within a predetermined range from the detected pressure of the load cell 6 ( (Not shown). Of course, the probe 8 is moved upward by controlling the rotation of the stepping motor.

  In other words, the movement of the probe 8 is performed by automatic control, which saves time and effort and allows the contact pressure of the probe 8 to be always set with high accuracy.

Since other configurations are the same as those of the second embodiment, the same components are denoted by the same reference numerals and description thereof is omitted. Of course, the auto Z-axis stage 40 with a stepping motor of this embodiment may be adopted in the first embodiment.
(Embodiment 4)
In this embodiment, as shown in FIG. 5B, an auto Z-axis with a stepping motor is attached to a movable body 50 that is attached to the side surface of the probe support 2 so as to be movable up and down and moves up and down by the rotation of the manual operation unit 4 ′. The probe support part side contact body 51 is attached together with the stage 40 so that the probe support part side contact body 51 can be brought into contact with or separated from the upper surface of the arm fixing body 11. It is. The feature is that the probe support side contact portion 51 is brought into contact with the upper surface of the arm fixing body 11 during measurement, and the skin of the arm 9 is pressed from the upper surface via the arm fixing body 11, thereby stabilizing the skin state during measurement. The spectrum measurement can be performed stably.

Since other configurations are the same as those of the third embodiment, the same components are denoted by the same reference numerals and description thereof is omitted. Of course, the probe support side contact body 51 of the present embodiment may be employed in the first and second embodiments.
(Embodiment 5)
In the first to fourth embodiments, the arm holder 3 and the arm fixing body 11 are positioned by fitting the convex portion 12a of the arm fixing body 11 to the recess 12b of the arm holder 3, but in this embodiment, The lock state is released only when the force for pulling the arm fixing body 11 away from the arm rest 3 is applied to a predetermined value or more, and in other cases, there is a feature in that a lock mechanism that holds the positioning state is provided. It can also be adopted in the embodiment.

  That is, on the arm fixing body 11 side, as shown in FIG. 6A, hemispherical engagement concave portions 60a are provided on both side surfaces of the convex portion 12a provided on the lower surface of the lower body 11b, and on the other hand, FIG. As shown, a ball-shaped key portion 60b protrudes from both inner surfaces of the concave portion 12b of the arm rest 3 to which the convex portion 12a is fitted. As shown in FIG. 6 (c), the ball-shaped key portion 60b is attached to the tip of a coil spring 62 housed in a groove portion 61 provided in the arm rest 3 on both sides of the recess 12, and is always directed toward the back portion 12a. When the convex portion 12a of the arm fixing body 11 is fitted into the concave portion 12b, the ball-shaped key portion 60b is pushed into the groove portion 61 by being pushed by the outer surface of the convex portion 12a. When the convex portion 12a moves in the concave portion 12b to the position where the combined concave portion 60a faces the key portion 60b, the key portion 60b is fitted into the engaging concave portion 60a by the urging force of the coil spring 62, and the convex portion 12a and the concave portion 12b are fitted. Lock the combined state. That is, the engagement recess 60a and the key portion 60b constitute a lock mechanism.

  On the other hand, when trying to move the arm fixing body 11 in the direction in which the arm fixing body 11 is pulled away from the arm rest 3, the amount in the direction of the coil spring 62 received by the key portion 60b from the inner surface of the engaging recess 60a on the convex portion 12b side to be moved in the pulling direction. If the force is larger than the urging force of the coil spring 62, the key portion 60b can be moved while being pushed into the groove portion 61. That is, the locked state is released, and finally, the convex portion 12 a comes out of the concave portion 12 b and the arm fixing body 11 is separated from the arm rest 3.

If the lock mechanism of the present embodiment is employed, the positioned state can be maintained with high accuracy, and the force in the direction in which the arm fixing body 11 is pulled away from the arm rest 3 is resisted to the urging force of the coil spring 62. The lock state can be released simply by increasing the size.
(Embodiment 6)
In this embodiment, as shown in FIGS. 7A and 7B, a grip portion 70 is provided to define the angle of the wrist 9a with the arm fixing member 11 positioned on the arm rest 3 and the arm 9 being placed. It is a thing. The grip 70 is supported on a support body 71 suspended on the base body 1, and one end is fixedly supported on the support body 71 so that the arm 9 is positioned on the arm rest 3 and the arm 9 is placed. And a grip bar 72 extending in the lateral direction. Other configurations may be the configurations of any of the above embodiments, and are not shown here.

  Thus, in this embodiment, when the arm individual 3 is positioned on the arm rest 3 and the arm 9 is placed at the time of measurement, the angle of the wrist 9a is grasped by grasping the grip rod 72 of the grip portion 70 by the subject. Can be defined. Therefore, it is possible to reproduce the state of the muscle near the through hole 16 of the arm fixing body 11 that guides the probe 8 every measurement. That is, the angle at which the probe 8 contacts the skin, the depth at which the probe 8 enters the skin, and the like can be reduced from measurement to measurement, and the light path passing through the skin can be stably obtained. .

  As shown in FIG. 8A, the grip portion 7 includes a support body 71 suspended from the base body 1 and a fixed body extending in the lateral direction with one end fixedly supported in the same manner as the grip rod 72 described above. 73, a joint 74 fixed to the upper portion of the fixed body 73, and a gripping rod 72 ′ having both ends connected to both ends of the joint 74 via belts 75, 75.

  Moreover, it is good also as a structure which can adjust the position of the grip bar 72 'of the grip part 70 so that it can respond to a test subject's individual difference. For example, as shown in FIG. 8B, a through hole 74a is provided at the base of the joint 74, and the fixing body 73 is inserted into the through hole 74a, so that the joint 74 extends in the direction of both ends of the fixing body 73, that is, the extension of the arm 9. It is possible to move in a direction orthogonal to the direction, and the position of the grip bar 72 'in the same direction is made to correspond to the individual difference of the subject. This moving position is fixed by tightening the tip of the fixing screw 76 screwed into the screw hole 74 b communicating with the through hole 74 a from the lower part of the joint 74 to the fixed body 73. The arm 9 is fixed to the base body 1 via a base 77 having a slide mechanism for supporting the lower portion of the support 71 so that the position of the support 71 can be adjusted by moving the arm 9 in the extending direction. The position of the support 71, that is, the gripping rod 73, with respect to the extending direction of the arm can be adjusted. This moving position can be fixed by tightening the lower portion of the support 71 with a fixing screw 78 screwed from the side surface of the base 77.

Furthermore, a cylindrical portion 73a is provided at one end of the fixed body 73, and a columnar support 71 is inserted into a through hole of the cylindrical portion 73a so that the fixed body 73 can be rotated in the horizontal direction around the support 71. It is movable up and down, the height position of the fixed body 73, that is, the height position of the gripping rod 73 can be adjusted, and the horizontal rotation, the movement of the joint 74, and the movement of the support body 71 can be performed. By combining, it is possible to cope with individual differences of subjects. This height position and rotation position can be fixed by tightening the support 71 with a fixing screw 79 screwed from the side surface of the cylindrical portion 73a.
(Embodiment 7)
This embodiment of the in-vivo component measuring apparatus using the in-vivo component-measuring probe support according to any of the first to sixth embodiments will be briefly described with reference to FIG. This apparatus is basically the same as the apparatus disclosed in Patent Document 1 described above, but is different in that any one of the in-vivo component measuring probe supports of Embodiments 1 to 6 is employed.

  In FIG. 9, reference numeral 100 denotes a light source such as a halogen lamp, 101 denotes a diffuser plate, 102 denotes a pinhole, and 103 denotes a lens. Near infrared light emitted from the light source 100 passes through the diffuser plate 101, the pinhole 102, and the lens 103. The light passes through and enters the light incident body 104. One end of the light emitting side optical fiber 105 and one end of the reference light emitting side optical fiber 106 are connected to the light incident body 104. The other end of the light emission side optical fiber 105 is connected to the measurement probe 8 fixed to the probe fixture 7 of the in vivo component measurement probe support of the present invention, and the other end of the reference light emission side optical fiber 106. Is connected to a reference probe 107. One end of a light receiving side optical fiber 108 is connected to the probe 8, and one end of a reference light receiving side optical fiber 109 is connected to the reference probe 107. The other end of the light receiving side optical fiber 108 is connected to the light receiving side light emitting body 110, and the other end of the reference light receiving side optical fiber 109 is connected to the reference light receiving side light emitting body 111.

  When the light source 100 emits light with the tip surface of the probe 8 in contact with the surface of the human arm 9 at a predetermined pressure, near-infrared light incident on the light incident body 104 from the light source 100 is emitted from the light-emitting side. The light is transmitted through the fiber 105 and irradiated from the tip of the probe 8 to the surface of the arm 9. After the measurement light applied to the arm 9 is reflected or diffused in the living body, the reflected light is received by the light receiving side optical fiber 108 from the tip of the probe 8. The received light is transmitted through the light receiving side optical fiber 108 and emitted from the light receiving side light emitting body 110. The light emitted from the light receiving side light emitting body 110 is incident on the diffraction grating 113 through the lens 112 and dispersed, and then detected by the light receiving element 114 which is a means for detecting reflected light. The optical signal detected by the light receiving element 114 is AD converted by the A / D converter 115 and then input to the arithmetic device 116 such as a personal computer to analyze the spectrum which is a biological signal in the detected optical signal. To calculate the blood sugar level and the like. Note that a known method such as the method disclosed in Patent Document 1 described above may be used as the spectrum calculation method, and thus the description thereof is omitted.

  Also, depending on the ambient temperature fluctuation and the positional relationship of the optical components, the irradiation light may fluctuate and affect the measured reflected light spectrum (change in shape, change in size level). This variation needs to be corrected. For this purpose, the reference light reflected from the reference plate 117 such as a ceramic plate is measured, and correction is performed using this as the reference light. That is, near infrared light incident on the light incident body 104 from the light source 100 is irradiated from the tip of the reference probe 107 to the surface of the reference plate 117. When the reflected light of the light irradiated on the reference plate 117 is received by the reference light receiving side optical fiber 109 from the tip of the reference probe 107, the reference light is passed through the reference light receiving side optical fiber 101 and then the reference light receiving side light emitting body. 1113 is emitted. Shutters 118a and 118b are disposed between the light receiving side light emitting member 110 and the lens 112 and between the reference light receiving side light emitting member 111 and the lens 112, respectively. By opening and closing, either the light from the light receiving side light emitting body 110 or the light from the reference light receiving side light emitting body 111 is selectively passed. Then, by detecting the reference light from the reference light-receiving side light emitter 111, it is possible to correct variations due to the ambient environmental temperature, the positional relationship of the optical components, and the like using this as the reference light.

  Next, an in vivo component measurement probe support (hereinafter referred to as support A) provided with a grip 70 in the apparatus, and an in vivo component measurement probe support (hereinafter referred to as support B) that does not include the grip 70. And a probe support for measuring in-vivo components (hereinafter referred to as support) for which there is no positioning part for determining the position between the arm fixing part 11 and the arm rest 3 and no grip part 70 is provided. In-vivo components were measured for evaluation using the tool C).

  This in-vivo component measurement is performed by connecting the arm fixing body 11 attached to the arm 9 of the subject to the arm rest 3 of each in-vivo component measuring probe support by an uneven fitting every hour, Each time the measurement was completed, the arm fixing body 11 was removed from the in vivo component measurement probe support while being attached to the arm 9, and the subject waited until the next measurement.

  One measurement is performed three times at three minute intervals, and the third spectrum measurement is performed by moving the probe 8 up and down for each spectrum measurement to bring it into contact with or separated from the skin. And measured. During the three spectrum measurements, the arm was conscious not to move from a predetermined position.

  The interval of 3 minutes is set so that the time required for applying the predetermined pressure shown in the following 4 to the arm after the probe 8 is brought into contact with the arm 9 and the predetermined pressure are measured for one spectrum measurement. This is to sufficiently take into account the time for the skin condition to stabilize after being applied and the time for moving the probe 8 up and down as shown in FIG.

  The probe 8 used was a cylindrical probe with a 4 mm diameter arm contact surface, the contact pressure to the arm 9 was 60 gf, and the contact pressure was controlled by the detected pressure of the load cell 6.

  The spectrum was measured in the range of 1430 nm to 1900 nm. Moreover, the stability of the spectrum is obtained by subtracting the value of 1655 nm from the value of 1655 nm (hereinafter referred to as the baseline), the value obtained by subtracting the value of 1655 nm from the value of 1449 nm (hereinafter referred to as the water peak height), and the value of 1725 Cape. (Hereinafter referred to as fat peak height).

  The measurement results using the above supports A to C are as shown in FIGS. (A) indicates the baseline, (B) indicates the water peak height, and (C) indicates the fat peak height.

  As can be seen from this result, the stability of the spectrum is most stable in the support A as shown in FIG. 10A, and then the support B shown in FIG. The support C was shown in FIG. In other words, these results show that even when the same in-vivo component measuring device is used, the in-vivo component-measuring probe support tool (support tools A and B) according to the present invention is used when the support tool C is used. It shows that the reproducibility of the arm position at the time of measurement is higher than that of.

(A) is the front view which abbreviate | omitted and fractured | ruptured Embodiment 1, (b) is a perspective view of the arm stand used for Embodiment 1. FIG. (A) is an expansion perspective view of the arm fixing body used for Embodiment 1, (b) is a perspective view of the lower body of the same arm fixing body. (A) shows the mounting state of the arm fixing body used for Embodiment 1, (a) is a perspective view which is partially broken, and (b) is a broken side view. (A) is a partially omitted and broken front view of the second embodiment, (b) is a side sectional view of the arm rest used in the second embodiment, and (c) is a support of the arm rest used in the second embodiment. An enlarged perspective view, (d) is a perspective view of an arm rest used in the second embodiment. (A) is a partially omitted and broken front view of the third embodiment, and (b) is a partially omitted and broken front view of the fourth embodiment. (A) is a perspective view of the lower body of the arm fixing body used in the fifth embodiment, (b) is a perspective view of the arm rest used in the fifth embodiment, and (c) is a plane of the arm rest used in the fifth embodiment. It is sectional drawing. (A) is a side view of a main part that can be partially omitted and broken in the sixth embodiment, and (b) is a front view of a grip portion used in the sixth embodiment. (A) is a front view of another example of the grip part used for Embodiment 6, (b) is a perspective view of the other example used for Embodiment 6. FIG. It is a block diagram of the in-vivo component measuring apparatus of Embodiment 7. In the in-vivo component measuring device of Embodiment 7, it is a graph of the measurement result using the probe support for in-vivo component measurement of the present invention, and a comparative example.

Explanation of symbols

DESCRIPTION OF SYMBOLS 1 Base body 2 Probe support body 3 Arm stand 4 Manual operation part 5 Moving body 6 Load cell 7 Probe fixing tool 8 Probe 9 Arm 10 Optical fiber 11 Arm fixing body 11a Upper body 11b Lower body 12a Convex part 12b Concave part 13 Concave part 14 Mounting belt 16 Through hole 17 Pad

Claims (5)

A means for mounting on the arm of the subject and an arm fixing body having a through hole for guiding a measurement probe to the surface of the arm, a probe support for determining a reference position of the probe, and a position of the probe support are fixed A probe support for measuring in-vivo components, comprising a positioning unit that detachably defines a positional relationship between the arm mount and the arm fixing body. . The in-vivo component measuring probe support according to claim 1, wherein the positioning portion is formed by a pair of non-circular uneven portions fitted to each other. The positioning portion locks the arm rest and the arm fixing body, and releases a lock when a force of a predetermined value or more is applied in a direction separating the arm rest and the arm fixing body. The probe support for in-vivo component measurement according to claim 1 or 2, characterized by comprising: The in-vivo component measuring probe support device according to any one of claims 1 to 3, further comprising a grip portion that defines a wrist angle with an arm placed on the arm rest. 5. The near-infrared light is transmitted to the in-vivo component measurement probe support according to claim 1 and the measurement probe mounted on the in-vivo component measurement probe support via a measurement optical fiber. A light source to be sent; a light receiving element that receives light reflected by the light receiving optical fiber having one end connected to the probe and is emitted from the other end through optical means; and reflected light received by the light receiving element An in-vivo component measuring apparatus comprising: an arithmetic device that calculates in-vivo components by analyzing a spectrum that is a bio-signal included in the in-vivo signal.

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