JP2006527232A5 - - Google Patents

Info

Publication number

JP2006527232A5

JP2006527232A5 JP2006515900A JP2006515900A JP2006527232A5 JP 2006527232 A5 JP2006527232 A5 JP 2006527232A5 JP 2006515900 A JP2006515900 A JP 2006515900A JP 2006515900 A JP2006515900 A JP 2006515900A JP 2006527232 A5 JP2006527232 A5 JP 2006527232A5

Authority

JP

Japan

Prior art keywords

glutaminase

compound

activity

preparation according

anthracyclines

Prior art date

2004-06-11

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Pending

Links

• Espacenet
• Global Dossier
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• 108010073324 Glutaminase Proteins 0.000 claims 6
• 102000009127 Glutaminase Human genes 0.000 claims 6
• 150000001875 compounds Chemical class 0.000 claims 5
• 230000000694 effects Effects 0.000 claims 5
• 229940034982 antineoplastic agent Drugs 0.000 claims 3
• AOJJSUZBOXZQNB-TZSSRYMLSA-N Doxorubicin Chemical compound O([C@H]1C[C@@](O)(CC=2C(O)=C3C(=O)C=4C=CC=C(C=4C(=O)C3=C(O)C=21)OC)C(=O)CO)[C@H]1C[C@H](N)[C@H](O)[C@H](C)O1 AOJJSUZBOXZQNB-TZSSRYMLSA-N 0.000 claims 2
• RJURFGZVJUQBHK-UHFFFAOYSA-N actinomycin D Natural products CC1OC(=O)C(C(C)C)N(C)C(=O)CN(C)C(=O)C2CCCN2C(=O)C(C(C)C)NC(=O)C1NC(=O)C1=C(N)C(=O)C(C)=C2OC(C(C)=CC=C3C(=O)NC4C(=O)NC(C(N5CCCC5C(=O)N(C)CC(=O)N(C)C(C(C)C)C(=O)OC4C)=O)C(C)C)=C3N=C21 RJURFGZVJUQBHK-UHFFFAOYSA-N 0.000 claims 2
• 239000013543 active substance Substances 0.000 claims 2
• 229940045799 anthracyclines and related substance Drugs 0.000 claims 2
• 239000002246 antineoplastic agent Substances 0.000 claims 2
• 238000009472 formulation Methods 0.000 claims 2
• 238000004519 manufacturing process Methods 0.000 claims 2
• 239000000203 mixture Substances 0.000 claims 2
• 108010033586 polyethylene glycol-glutaminase-asparaginase Proteins 0.000 claims 2
• STQGQHZAVUOBTE-UHFFFAOYSA-N 7-Cyan-hept-2t-en-4,6-diinsaeure Natural products C1=2C(O)=C3C(=O)C=4C(OC)=CC=CC=4C(=O)C3=C(O)C=2CC(O)(C(C)=O)CC1OC1CC(N)C(O)C(C)O1 STQGQHZAVUOBTE-UHFFFAOYSA-N 0.000 claims 1
• 108010092160 Dactinomycin Proteins 0.000 claims 1
• WEAHRLBPCANXCN-UHFFFAOYSA-N Daunomycin Natural products CCC1(O)CC(OC2CC(N)C(O)C(C)O2)c3cc4C(=O)c5c(OC)cccc5C(=O)c4c(O)c3C1 WEAHRLBPCANXCN-UHFFFAOYSA-N 0.000 claims 1
• 206010028980 Neoplasm Diseases 0.000 claims 1
• 239000002202 Polyethylene glycol Substances 0.000 claims 1
• 241000589516 Pseudomonas Species 0.000 claims 1
• 241000920685 Pseudomonas sp. 7A Species 0.000 claims 1
• RJURFGZVJUQBHK-IIXSONLDSA-N actinomycin D Chemical compound C[C@H]1OC(=O)[C@H](C(C)C)N(C)C(=O)CN(C)C(=O)[C@@H]2CCCN2C(=O)[C@@H](C(C)C)NC(=O)[C@H]1NC(=O)C1=C(N)C(=O)C(C)=C2OC(C(C)=CC=C3C(=O)N[C@@H]4C(=O)N[C@@H](C(N5CCC[C@H]5C(=O)N(C)CC(=O)N(C)[C@@H](C(C)C)C(=O)O[C@@H]4C)=O)C(C)C)=C3N=C21 RJURFGZVJUQBHK-IIXSONLDSA-N 0.000 claims 1
• 230000000118 anti-neoplastic effect Effects 0.000 claims 1
• 201000011510 cancer Diseases 0.000 claims 1
• 229960004562 carboplatin Drugs 0.000 claims 1
• 190000008236 carboplatin Chemical compound 0.000 claims 1
• 239000000969 carrier Substances 0.000 claims 1
• DQLATGHUWYMOKM-UHFFFAOYSA-L cisplatin Chemical compound N[Pt](N)(Cl)Cl DQLATGHUWYMOKM-UHFFFAOYSA-L 0.000 claims 1
• 229960004316 cisplatin Drugs 0.000 claims 1
• 229960000640 dactinomycin Drugs 0.000 claims 1
• STQGQHZAVUOBTE-VGBVRHCVSA-N daunorubicin Chemical compound O([C@H]1C[C@@](O)(CC=2C(O)=C3C(=O)C=4C=CC=C(C=4C(=O)C3=C(O)C=21)OC)C(C)=O)[C@H]1C[C@H](N)[C@H](O)[C@H](C)O1 STQGQHZAVUOBTE-VGBVRHCVSA-N 0.000 claims 1
• 229960004679 doxorubicin Drugs 0.000 claims 1
• 239000003814 drug Substances 0.000 claims 1
• 229960001156 mitoxantrone Drugs 0.000 claims 1
• KKZJGLLVHKMTCM-UHFFFAOYSA-N mitoxantrone Chemical compound O=C1C2=C(O)C=CC(O)=C2C(=O)C2=C1C(NCCNCCO)=CC=C2NCCNCCO KKZJGLLVHKMTCM-UHFFFAOYSA-N 0.000 claims 1
• 229960001756 oxaliplatin Drugs 0.000 claims 1
• DWAFYCQODLXJNR-BNTLRKBRSA-L oxaliplatin Chemical compound O1C(=O)C(=O)O[Pt]11N[C@@H]2CCCC[C@H]2N1 DWAFYCQODLXJNR-BNTLRKBRSA-L 0.000 claims 1
• 239000000825 pharmaceutical preparation Substances 0.000 claims 1
• 229920001223 polyethylene glycol Polymers 0.000 claims 1
• 238000002560 therapeutic procedure Methods 0.000 claims 1