JP2006520195A5 - - Google Patents
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- Publication number
- JP2006520195A5 JP2006520195A5 JP2006503098A JP2006503098A JP2006520195A5 JP 2006520195 A5 JP2006520195 A5 JP 2006520195A5 JP 2006503098 A JP2006503098 A JP 2006503098A JP 2006503098 A JP2006503098 A JP 2006503098A JP 2006520195 A5 JP2006520195 A5 JP 2006520195A5
- Authority
- JP
- Japan
- Prior art keywords
- oligonucleotide
- cell
- hif
- human
- compound according
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 108091034117 Oligonucleotide Proteins 0.000 claims 10
- 102100032742 Histone-lysine N-methyltransferase SETD2 Human genes 0.000 claims 8
- 101000654725 Homo sapiens Histone-lysine N-methyltransferase SETD2 Proteins 0.000 claims 8
- 150000001875 compounds Chemical class 0.000 claims 8
- 210000004027 cell Anatomy 0.000 claims 6
- 239000000074 antisense oligonucleotide Substances 0.000 claims 4
- 238000012230 antisense oligonucleotides Methods 0.000 claims 4
- 239000008194 pharmaceutical composition Substances 0.000 claims 4
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 2
- 206010028980 Neoplasm Diseases 0.000 claims 2
- 201000011510 cancer Diseases 0.000 claims 2
- 230000003013 cytotoxicity Effects 0.000 claims 2
- 231100000135 cytotoxicity Toxicity 0.000 claims 2
- 210000005260 human cell Anatomy 0.000 claims 2
- 108020004707 nucleic acids Proteins 0.000 claims 2
- 150000007523 nucleic acids Chemical class 0.000 claims 2
- 102000039446 nucleic acids Human genes 0.000 claims 2
- 230000008685 targeting Effects 0.000 claims 1
- RYYWUUFWQRZTIU-UHFFFAOYSA-K thiophosphate Chemical compound [O-]P([O-])([O-])=S RYYWUUFWQRZTIU-UHFFFAOYSA-K 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US76618503A | 2003-01-28 | 2003-01-28 | |
| US44436703P | 2003-01-31 | 2003-01-31 | |
| PCT/US2004/002344 WO2004066949A2 (en) | 2003-01-28 | 2004-01-28 | Antisense oligonucleotides that inhibit expression of hif-1 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2006520195A JP2006520195A (ja) | 2006-09-07 |
| JP2006520195A5 true JP2006520195A5 (enExample) | 2007-03-15 |
| JP4546454B2 JP4546454B2 (ja) | 2010-09-15 |
Family
ID=32829853
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006503098A Expired - Fee Related JP4546454B2 (ja) | 2003-01-28 | 2004-01-28 | Ｈｉｆ−１発現を抑制するアンチセンスオリゴヌクレオチド |
Country Status (3)
| Country | Link |
|---|---|
| JP (1) | JP4546454B2 (enExample) |
| AU (1) | AU2004207576B8 (enExample) |
| WO (1) | WO2004066949A2 (enExample) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2011353283A1 (en) | 2010-12-30 | 2013-07-18 | Samyang Biopharmaceuticals Corporation | siRNA for inhibition of Hif1alpha expression and anticancer composition containing the same |
| US10307490B2 (en) * | 2012-05-23 | 2019-06-04 | The Ohio State University | Lipid nanoparticle compositions for antisense oligonucleotides delivery |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5882914A (en) | 1995-06-06 | 1999-03-16 | The Johns Hopkins University School Of Medicine | Nucleic acids encoding the hypoxia inducible factor-1 |
| WO2000076497A1 (en) * | 1999-06-14 | 2000-12-21 | Cancer Research Ventures Limited | Cancer therapy |
| US7105656B2 (en) * | 2000-10-26 | 2006-09-12 | The Brigham And Women's Hospital, Inc. | Compositions and methods for treating hematologic malignancies and multiple drug resistance |
| HUE037352T2 (hu) * | 2002-04-05 | 2018-08-28 | Roche Innovation Ct Copenhagen As | A HIF-1alfa expresszálódását módosító oligomer vegyületek |
| US7144999B2 (en) * | 2002-11-23 | 2006-12-05 | Isis Pharmaceuticals, Inc. | Modulation of hypoxia-inducible factor 1 alpha expression |
-
2004
- 2004-01-28 JP JP2006503098A patent/JP4546454B2/ja not_active Expired - Fee Related
- 2004-01-28 WO PCT/US2004/002344 patent/WO2004066949A2/en not_active Ceased
- 2004-01-28 AU AU2004207576A patent/AU2004207576B8/en not_active Ceased
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