JP2006516101A - Fluid dispenser comprising a rigid vial and an inner flexible sac - Google Patents

Abstract

An ophthalmic dispenser includes a rigid housing that defines a fluid receiving chamber, a flexible bladder that is installable within the fluid receiving chamber, a pump that is coupled in fluid communication with the fluid receiving chamber, and an annular, axially extending valve. A valve defining a seat, a discharge port connected in fluid communication between the valve seat and the pump, a flexible valve cover extending around the valve seat and forming an annular, axially extending contact surface therebetween A nozzle. The contact surface of the valve is connectable in fluid communication with the outlet, and at least a portion of the valve cover includes: (i) the valve cover engages the valve seat to close the contact surface, while the fluid tight seal In a normally closed position, and (ii) at least a portion of the valve cover leaves the valve seat in response to pumped liquid flowing from the outlet at a pressure greater than the pressure for opening the valve. , And can be moved between an open position in which the pressurized liquid flows. A spring is drivably connected to the housing and moves at least one of the pump or housing relative to the other to activate the pump. The rigid housing can be installed within the cartridge, and the cartridge can be mounted within the housing of a dispenser that has a heel presser and a trigger that activates the heel presser and the pump simultaneously.

Description

  The present invention generally includes a dispenser and method for storing and delivering fluids and other materials, and a method thereof, and, for example, a rigid vial and a flexible bladder installed within the rigid vial. And a dispenser comprising a nozzle and pump assembly for supplying fluid and other substances therefrom, which is coupled in fluid communication with the chamber. The present invention relates to a method for manufacturing, distributing or selling a dispenser.

  This patent application is a continuation-in-part of US patent application Ser. No. 10 / 001,745 entitled “Fluid Dispenser with Rigid Vial and Flexible Inner Cap” filed on Oct. 23, 2001. No./001,745 is the benefit of US Provisional Application No. 60 / 242,595, filed Oct. 23, 2000, and US Provisional Application No. 60 / 242,974, filed Oct. 24, 2000. Each of which is expressly incorporated by reference as part of the present application. This patent application is also filed in US Provisional Application Nos. 60 / 443,524, filed Jan. 28, 2003 and entitled "Fluid Dispenser with Rigid Vial and Flexible Inner Pouch" and Oct. 21, 2002. We claim the benefit of US Provisional Patent Application No. 60 / 420,334 of similar title, each of which is expressly incorporated by reference as part of this application.

  A typical fluid dispenser includes a container having a chamber for receiving fluid to be supplied therein, a nozzle and pump assembly installed in the container, and extending downwardly from the nozzle into the chamber. A drop tube for pumping liquid from the bottom of the chamber out of the dispenser. Other known dispensers have a vial and a flexible bladder placed in the vial. For example, in US Pat. No. 6,062,430 to Fuchs, in FIG. 1, a bottle-shaped container 2 having a thin-walled hollow body made of a soft elastic plastic and enclosed in the container body 2 A supply container with variable capacity compensation function is shown, comprising a receiving container 15 formed of wrinkle film.

  One of the disadvantages found with typical prior art fluid dispensers is that the fluid chamber is not held substantially airless until the dispenser is stored, stored or expired. For example, nozzles and valves used in typical prior art dispensers often cannot keep the dispenser airtight. In the case of such nozzles and valves, air and other gases pass through them and come into contact with drugs and other substances held in the fluid chamber. Furthermore, it is frequently seen that such nozzles and valves are subject to loss due to evaporation either during storage, storage or use of the dispenser.

  Another drawback of prior art dispensers is that component material creep occurs, thereby leaking from the seal formed in the dispenser. Many drugs are stored in a storage facility or store shelves for at least several months and possibly months. During transport and storage, the dispenser is subject to changes in atmospheric conditions with significant fluctuations in temperature, pressure and humidity. As a result, the dispenser often undergoes substantial thermal expansion and contraction changes that cause the material to creep. Prior art dispenser seals and other components such as those described above are not designed to accommodate such creep, so they may leak from the dispenser when stored for extended periods of time or subject to changes in atmospheric conditions. Loss due to air ingress or evaporation. For example, some polyethylene dispensers have been found to lose about 10% to about 25% by weight of content during storage. Such weight loss may be due to evaporation loss from the chamber containing the drug or other fluid through the polyethylene wall of the dispenser, or due to leakage of the seal or other structural joints of the container. Evaporation losses are usually compensated by air ingress into the chamber. Evaporation loss or air intrusion tends to dilute the prescribed dose of the drug supplied from the container each time in the case of a dispenser containing drugs such as drugs and vaccines. This is especially a problem because the concentration is different each time.

  Another disadvantage of prior art dispensers is that they do not reliably hold drugs or other substances contained in them in an airtight state, so they do not contain preservatives or drugs that are administered multiple times. It cannot be used for any of the formulations. A single dispenser can be substantially more expensive than a multiple dispenser. Furthermore, preservatives used in many drugs such as pharmaceuticals and vaccines can cause side effects on the patient or reduce the effectiveness of the drug on the patient.

  Another disadvantage of prior art dispensers is that the deposits are caused by the ullage, or "dead space", characteristic of this type of dispenser. Many of the drugs and other formulations contained in such dispensers are suspensions. Due to the allocator, or dead space, of the prior art dispenser, the solute and other solid components of the suspension form precipitates therein. This sedimentation of the suspension dilutes the drug or other substance contained in the dispenser, thereby changing the drug or drug concentration in each dose to the patient.

  Another disadvantage associated with many prior art dispensers is that they can only deliver the drug or other material contained therein in an upright state or in some other orientation. Because of this drawback, this type of dispenser cannot be used effectively if it is upside down or otherwise oriented. In addition, these dispensers cannot be used in a low-gravity environment such as outer space because they cannot keep the drugs and other substances in the airless.

  Dispensers for storing and supplying fluids (other substances) are used in various applications. One example is ophthalmic treatment. In fact, many dispensers have been developed to deliver eye drops to the eye. Some such dispensers include flexible vials that deliver medication when compressed against the side walls of the vial. This type of dispenser is commonly referred to as an “eye drop container”. Less commonly, some dispensers have a pump-type delivery system.

  Various problems can occur when applying correctly. For example, it is difficult for many people to put droplets in their eyes. The eye is a very sensitive part of the body, and humans find it difficult to control the reflexive blinking when putting a drop of water into the eye. Also, if there is a user who cannot position the tip of the eye drop bottle well above the eye, there are also people who are difficult to hold the bottle firmly or press the bottle to instill the correct amount. In addition, it is often desirable to deliver a drug to a specific area of the eye. For example, when applying eye drops to the surface of the eyeball, blinking and natural tears remove or dilute the drug, limiting the effect of the drug. In addition, some drugs cause “eye congestion” when applied directly to the cornea region of the eyeball. On the other hand, if the drug reaches the conjunctival sac, the drug becomes less susceptible to blinking and tearing, and the effect lasts for a long time.

  Some dispensers have features to address one or several of the above problems. Examples of such features include a kite cover, a kite presser, a pump-type supply system, a trigger mechanism, and the like. Using the eyelid cover makes it easier to position the dispenser correctly on the top of the eye. Acupuncture helps to expose the conjunctival sac. A pump-type delivery system aids in drug delivery. The trigger mechanism allows the user to operate the delivery system more conveniently.

  One drawback with such a dispenser is that its cost is higher than desired. Furthermore, even if this type of dispenser can be purchased, other features of the cheaper dispenser may not be available. As a result, it is desirable for manufacturers of such dispensers to provide cheaper products in order to reach all areas of the market.

  Another disadvantage of this dispenser is that it is bulkier than a dispenser without the above features and less transportable than desired (eg, carried in a pocket, ship, etc.).

  Another disadvantage of this type of dispenser is that it limits the amount of drug (or other fluid) that can be stored in the dispenser. Most (but not all) have this drawback, but some dispensers are so expensive that they cannot be thrown away when empty. Many such dispensers cannot be refilled because the user cannot easily access the chamber. Some types of dispensers use replaceable cartridges, but this solves the refill problem, but its actuation mechanism is less user-friendly than what is currently required.

  Another drawback associated with many of the above dispensers is that a vacuum pump is required to properly fill and capping the chamber without spilling.

  Accordingly, it is an object of the present invention to overcome one or more of the above disadvantages or disadvantages of the prior art.

  The present invention relates to a dispenser for supplying fluid. In accordance with one aspect of the present invention, a dispenser includes a rigid housing, a flexible bladder disposed within the housing and defining an internal chamber, and a fluid receiving chamber between the flexible bladder and the rigid case. The dispenser further generates a first pressure in the fluid receiving chamber that is greater than a second pressure in the inner chamber within the bladder to prevent gas or vapor from entering the fluid receiving chamber. Means. In the presently preferred embodiment of the present invention, the means for generating the pressure difference comprises the sac with a recoverable material that deflects the sac outwardly into an expanded state, thereby providing a fluid receiving chamber. A first pressure greater than a second pressure in the internal chamber of the bladder is generated. Preferably, the recoverable sac is formed in an inflated state, so that the recoverable sac tends to inherently become inflated, thereby causing a gap between the fluid receiving chamber and the interior chamber of the sac. The desired pressure difference.

  One embodiment of the dispenser further includes a pump coupled in fluid communication with the fluid receiving chamber, a pump for pumping fluid in the chamber from the dispenser, and coupled in fluid communication with the pump for passing the pumped fluid through the interior. A one-way valve that prevents fluid from flowing to the opposite side. The one-way valve is preferably composed of a nozzle and a flexible cover located on the nozzle, and the one-way valve is formed at the interface between the nozzle and the cover.

  According to another aspect of the invention, the dispenser further comprises a seal formed between the flexible bladder and the rigid vial for sealing the fluid receiving chamber. The encapsulant is positioned on the outer surface of the flexible bladder radially extending first, and spaced axially with respect to the first bump and radially inward on the inner surface of the bladder. It has a second ridge that extends. The first and second ridges are radially compressed to seal the interface between the flexible bladder and the rigid vial. Preferably, the first ridge extends to the outer peripheral surface of the sac to define an outer annular sealing surface, and the second ridge extends to the inner peripheral surface of the sac to define an inner annular sealing surface. In addition, the first ridge directs the bladder material substantially in the direction of the second ridge, thereby helping to maintain fluid tightness when creep occurs in the bladder material. The seal also preferably includes a peripheral flange that extends to the open end of the flexible bladder and is axially compressed to further seal the contact surface between the bladder and the rigid vial.

  According to another aspect of the invention, the dispenser is further received in the open end of the rigid vial and engages at least one of the first and second ridges to radially compress the ridges. A plug is provided to seal the interface between the flexible bladder and the rigid vial. The plug defines therein at least one opening in fluid communication with the inner chamber of the flexible bladder. Preferably, the bidirectional valve of the dispenser is connected in fluid communication between the inner chamber of the flexible bladder and the opening of the stopper so that the pressure difference across the bidirectional valve is less than a limit value. To prevent fluid communication with the surrounding atmosphere. The bi-directional valve is preferably formed by a flexible annular ridge that extends radially inwardly from the inner peripheral surface of the flexible bladder, which engages the annular surface of the stopper and thereby between the flexible bladder and the stopper. Seal the joint surface. In one embodiment of the present invention, the annular ridges define axially opposed surfaces that are radially inwardly narrowed so that the pressure differential across the ridge exceeds a predetermined limit. Responsive to help the bulge bend.

  The flexure body of the dispenser further defines an open end and a closed end and varies between a collapsed state and an expanded state. As the flexible bladder expands from the collapsed state to the expanded state, the flexible bladder and the rigid vial define an annular gap therebetween. In one embodiment, the annular gap widens axially from the open end to the closed end of the flexible bladder, allowing fluid to exit the fluid receiving chamber when the bladder is inflated. Preferably, the flexible sac initially contacts the rigid vial at or near the open end of the sac and then expands axially from the open end to the closed end of the flexible sac as it expands. Gradually engage the rigid vial. Also, according to one embodiment of the dispenser, the flexible bladder defines an inflated outer shape, the rigid vial defines an inner shape, the outer and inner shapes are substantially the same, and the flexible bladder is rigid. There is almost no dead space in the fluid receiving chamber between and in contact with the vials.

  According to another aspect of the invention, a dispenser pump includes a piston and a slide that slidably receives the piston therein. At least one of the piston and the slide is reciprocable with respect to the other. In addition, the piston is made of a relatively hard material and the slide is made of a relatively soft material that causes the compression area of the slide to deflect outward when at least one of the piston and the slide moves relative to the other. This keeps the fluid tight between the piston and the slide. Furthermore, by forming the slide from a relatively flexible material, the slide can be integrally formed with the nozzle, for example by molding two components into a single part, in which case the integrated nozzle And the slide can be removed from the core pin by injecting compressed gas therebetween.

  According to another aspect of the invention, the dispenser further comprises means for controlling the collapse of the flexible sac to a predetermined collapsed state. In one embodiment of the present invention, the control means includes a plurality of legs extending axially inwardly into the inner chamber of the flexible sac and in contact with the flexible sac when the sac collapses. Prepare. In another embodiment of the invention, the control means is defined by a cut in at least one axially elongated surface formed in the flexible bladder.

  In other embodiments of the invention, the flexure sac can be penetrated by a needle or similar infusion member to introduce a predetermined substance into the fluid receiving chamber. In this embodiment, the flexible bladder is substantially injectable in response to the application of thermal energy thereto, and the first portion is compatible with the material received in the fluid receiving chamber; A second portion may be provided that is disposed over the portion and that is injectable in response to the application of thermal energy thereto. Thus, the second portion forms a substantial fluid tight seal in the portion that is penetrated by the needle or similar infusion member between the flexible bladder and the fluid receiving chamber. In one embodiment of the invention, the second portion is formed of either a thermoplastic or rubber-like material, and the bladder is formed of sulfurized rubber, including the first portion. Alternatively, a hole formed by a needle or other injection member by forming the entire penetrating portion of the flexible sac with a heat-resealable thermoplastic material and irradiating the laser beam with a predetermined wavelength and intensity. So that it can be sealed.

  According to another aspect of the present invention, a dispenser for storing and supplying fluid includes a housing, a first actuator coupled to the housing, and a self-contained cartridge. A self-contained cartridge includes a vial, the vial having an internal fluid receiving chamber defined therein, in fluid communication with the fluid receiving chamber, and a pump for pumping fluid received therein from the dispenser; A nozzle arranged in fluid communication with the pumped fluid therethrough, and a nozzle, pump, and vial in this order, held in a direction along the longitudinal axis toward the rear end of the dispenser A case. The case has a front wall having an opening for receiving a nozzle, and a second actuator is coupled to the case and is responsive to the first actuator. The second actuator is at least partially disposed on the outside of the case, and at least partially located on the inside of the case, and is operatively connected to at least one of the pump and the vial. In the first stage of actuation of the actuator, at least one of the pump and vial moves in the direction of the other along the longitudinal axis, and in the second stage of actuation by the actuator, at least one of the pump and vial is Move away from the other.

  According to another aspect of the present invention, a method including the following steps can be realized. Providing a plurality of cartridges for storing and supplying fluid; and the plurality of cartridges are substantially identical to each other, each comprising a vial, a pump and a nozzle, the vial having an internal fluid receiving chamber therein. The pump is in fluid communication with the fluid receiving chamber and pumps fluid therein from the dispenser, the nozzle is disposed in fluid communication with the pump, the pumped fluid can pass therethrough, and the cartridge further includes a nozzle, pump The vial is held in this order in a direction along the longitudinal axis toward the rear end of the cartridge, and the actuator is operatively connected to the pump, Mounting at least one in the dispenser and operably connecting the actuator to the cartridge; Operation of Chueta starts supplying, using at least one of the cartridge is and supplying a fluid without operably linked to the actuator to the cartridge attached to the cartridge in the dispenser.

  According to another aspect of the present invention, a method including the following steps can be realized. Providing a plurality of cartridges for storing and supplying fluid; and a plurality of cartridges substantially identical to each other, each comprising a vial, a pump and a nozzle, the vial having an internal fluid receiving chamber therein; The pump is in fluid communication with the fluid receiving chamber and pumps fluid therein from the dispenser, the nozzle is disposed in fluid communication with the pump, and the pumped fluid passes therethrough, and the cartridge further includes a nozzle, pump, A plurality of vials held in this order, arranged in a direction along the longitudinal axis toward the rear end of the cartridge, with an actuator operably connected to the pump and adapted to receive and operate the cartridge The step of installing the dispenser and the plurality of cartridges are substantially identical to each other and as independent units Or can operate in a dispenser, comprising the steps of selling at least one cartridge with at least one dispenser is a step of selling at least one of the cartridge without a dispenser.

  According to another aspect of the invention, a dispenser for supplying fluid comprises: Self-contained, replaceable cartridge. The cartridge is disposed in fluid communication with the rear portion having a vial with an internal fluid receiving chamber defined therein, a pump in fluid communication with the fluid receiving chamber and pumping fluid therein from the dispenser, A nozzle that allows the pumped fluid to pass therethrough, and a case that holds the nozzle, pump, and rear portion in this order, arranged in a direction toward the rear end of the dispenser along the longitudinal axis; The pump is operably connected to at least a portion of the rear portion and moves along the longitudinal axis in accordance with the movement of the portion of the rear portion on the shaft, and the case has a front having an opening for receiving the nozzle An actuator having a wall and operatively coupled to at least a portion of the rear portion, wherein in the first stage of operation, the actuator includes at least a portion of the rear portion. Move along the axis in the direction toward the rear edge of the case, thereby moving the pump in the same direction, and in the second stage of operation, the rear part moves along the vertical axis in the direction toward the front edge of the case. , Thereby moving the pump toward the front end of the case.

  According to yet another aspect of the present invention, a dispenser for supplying fluid comprises: cartridge. The cartridge includes a vial having an internal fluid receiving chamber defined therein, a pump in fluid communication with the fluid receiving chamber and pumping fluid therein from the dispenser, and a fluid pumped and disposed in fluid communication with the pump. Through which the nozzle passes, the spring portion disposed behind the internal fluid receiving chamber defined inside, the nozzle, the pump, and the vial in this order toward the rear end of the dispenser along the longitudinal axis. A case holding in a directional orientation and an actuator having a front wall with an opening for receiving the nozzle and operably connected to the pump, and in the first stage of operation, the actuator Move the pump along the length axis in the direction toward the rear edge of the case, thereby applying a force to the internal fluid receiving chamber and compressing the spring In the second stage of actuation, the compressed spring exerts a force to assist in moving in a direction toward the pump at the rear end of the case.

  According to another aspect of the present invention, a dispenser for supplying fluid comprises: Self-contained cartridge. The cartridge includes a vial having an internal fluid receiving chamber defined therein, a pump in fluid communication with the fluid receiving chamber and pumping fluid therein from the dispenser, and a fluid pumped and disposed in fluid communication with the pump. Through which the nozzle passes, the spring portion disposed behind the internal fluid receiving chamber defined inside, the nozzle, the pump, and the vial in this order toward the rear end of the dispenser along the longitudinal axis. A case holding in a state arranged in a direction, the case has a front wall having an opening for receiving a nozzle, an actuator having a first end and a second end, and the first end is Pivoted on the case, the second end is operably connected to the pump, and the actuator further has a pivot located between the first end and the second end.

  One advantage of the presently preferred embodiment of the present invention is that gas or other gases or vapors may be deflected from the flexor or other parts due to pressure differences between the fluid receiving chamber and the inner chamber of the bladder and the atmosphere. Entry into the fluid receiving chamber is substantially prevented. As a result, the dispenser according to the present invention is able to keep the medicaments and other substances contained therein airless during a sufficient period of storage, storage or use. Therefore, the dispenser of the present invention is particularly suitable for a case where a medicine or other substance containing no preservative, which needs to be stored in an airless state, is supplied several times.

  Another advantage of the presently preferred embodiment of the present invention is that the seal formed between the flexible bladder and the rigid vial directs the flexible bladder material in the radial and axial directions, and dispenser Even if material creep occurs during storage or storage, the fluid is kept fluid tight. In addition, the one-way valve used in the preferred embodiment of the present invention keeps the fluid receiving chamber more sealed throughout the storage, storage or use of the dispenser.

  Yet another advantage of the dispenser of the present invention is that the dispenser can be used in virtually any orientation and even in a low-gravity environment because drugs and other substances are kept airless in the fluid receiving chamber. Is a point.

  Another advantage of the dispenser of the present invention is that the flexible bladder defines an outer shape that substantially matches the inner shape of the rigid vial. As a result, the flexible bladder expands and contacts the rigid vial across the interface between the two portions, thereby eliminating dead space in the fluid receiving chamber.

  Another advantage of the presently preferred embodiment of the present invention is that a bi-directional valve connected in fluid communication between the inner chamber of the flexure bladder and the atmosphere has a predetermined pressure difference across the valve. As long as it is less than the level, it is to prevent any gas or vapor exchange between the internal chamber of the bladder and the atmosphere. As a result, the bi-directional valve forms a relatively stable micro-atmosphere within the inner chamber of the flexure sac, isolating the inner chamber from changes in atmospheric pressure or humidity, thereby further fluidizing Ingress of gas or vapor into the receiving chamber is prevented.

  One advantage of the presently preferred embodiment of the present invention is that the replaceable cartridge eliminates the need to return the dispenser to the factory for refilling. The dispenser can be refilled by installing a new cartridge. In addition, the cartridge has its own actuator, which is coupled to the actuator of the dispenser, and the dispenser operation is improved compared to prior art cartridge dispensers and meets the level of convenience currently desired. .

  Another advantage of the presently preferred embodiment of the present invention is that the actuator is on the cartridge, allowing the cartridge to be used as a dispenser.

  Another advantage of the presently preferred embodiment of the present invention is that the cartridge can be used as a dispenser so that the manufacturer sells the cartridge alone and reaches market areas where the dispenser cannot afford or intend to purchase the dispenser. It is a point that can be.

  Another advantage of the presently preferred embodiment of the present invention is that the merchant stores the cartridge and dispenser, sells the cartridge for the dispenser (whether or not with the dispenser), and sells the cartridge alone. Thus, it is possible to spread the market area where there is no room or intent to purchase the dispenser.

  Another advantage of the presently preferred embodiment of the present invention is that it is more convenient to carry (e.g., in a pocket, ship, etc.) because the cartridge is less bulky than the dispenser.

  One advantage of some embodiments of the present invention is that it is easier to use than conventional dispensers because the actuator has multiple pivot points.

  One advantage of some embodiments according to one aspect of the present invention is that a vacuum pump is not required to fill and cap the chamber without spilling.

  Other objects and advantages of various preferred embodiments of the present invention will become apparent from the following detailed description and the accompanying drawings.

  In FIG. 1, an ophthalmic treatment device 8 is shown according to the present invention that can be used in connection with a dispenser, generally designated 10. As seen in FIGS. 1 and 1A, the treatment device 8 has a housing 12 that is generally U-shaped in cross section and defines an internal cavity 14 and an eye cover 16. The trigger 18 has an arm portion 24 pivoted to the housing 12 by a hinge 22 at one end 20 and defining a slot 25 at the opposite end. As seen in FIG. 1A, the pin 26 of the wheel 27 is fixed in the slot 25, and the wheel 27 is rotatably mounted on the inner wall of the housing 12. As best seen in FIG. 1, the trigger 18 is elongated and has a finger groove 28 that fits comfortably into a patient's hand, for example. A substantially L-shaped spring arm 30 is fixed to one end of a post 29 projecting inwardly from the inner wall of the housing 12, and the spring arm engages the inner surface of the trigger 18, ie, a bend 31 ( The free end 32 engages a rim 34 formed at one end of the dispenser 10. The heel presser 36 is pivotally supported by the hinge 38 on the end of the housing 12 adjacent to the eye cover 16 and has a hook 40 fixed to a wheel 27 for pivoting the heel presser when the trigger 18 is operated.

  In use, the eye cover 16 is placed in the vicinity of the tissue around the eye with the eyelid holder 36 applied to the tissue in the vicinity of the conjunctival sac. When the trigger 18 is compressed, the eyelid presser 36 rotates in the direction of the arrow 41, which moves the tissue in the vicinity of the eye to expose the inside of the conjunctival sac of the eye. The rotation of the eaves holder 36 is caused by the wheel 27, which also opens the cover of the nozzle 42 formed at the adjacent end of the dispenser 10. At the same time, the spring arm 30 moves the rim 34 of the dispenser 10 away from the fixed nozzle 42, thereby preparing the dispenser pump. This will be described in detail later. When the trigger 18 is squeezed and the dispenser 10 in the housing 12 is correspondingly extended, the free end 32 of the spring arm 30 will eventually disengage from the rim 34 of the dispenser and the extended dispenser will be released from the spring arm. . As a result, as will be described later, due to the elasticity of the nozzle 42, that is, a spring-like property, the extended dispenser is pulled back, that is, in the direction of the nozzle. Released into the conjunctival sac of the user's eye. Thereafter, when the user removes the ophthalmic treatment device 8 from the eye and releases the trigger 18, the spring arm 30 automatically returns to the original or rest position shown in FIG. 1 and the free end 32 engages the rim 34. To do. Due to the force generated when the spring arm 30 returns to the original position, the wheel 27 is also rotated in the direction opposite to the arrow 41, and as a result, the eaves presser 36 returns to the original position as shown in the figure. At this time, the ophthalmic treatment device is ready to supply a predetermined amount of the medicine or other fluid contained therein.

  Other examples of ophthalmic treatment devices that can use the dispenser 10 are described in US Pat. Nos. 4,981,479 and 6,033,384. These are assigned to the assignee of the present invention and are incorporated herein by reference. Thus, as will be appreciated by those of ordinary skill in the art based on the teachings herein, the dispenser of the present invention can be used in a number of different devices or systems to contain drugs contained therein, such as nasal inhalers. It is possible to easily hold and supply other fluids, liquids and other substances.

  2 and 3, a partial cross-sectional view of the dispenser 10 is shown and its internal components are visible. The dispenser 10 is generally cylindrical in outer shape and includes a pump assembly 50, a generally rigid vial 52, and a flexible bladder disposed within the vial main fluid chamber 55. The pump assembly 50 includes a piston 56 for discharging a drug or other substance contained in the fluid chamber 55 by a predetermined dose, and a chamber in which the piston is slidably received and a predetermined dose is placed therebetween. And a pump cover 62 that moves the piston 58 or one of the pistons or nozzles toward the other together with the nozzle 58 at the position of the supply tip and spring-like bellows, A single dose of drug or other substance is discharged from the nozzle, and when a predetermined amount is released, a one-way valve is formed that moves one of the piston or nozzle away from the other. Nozzle 58 seals the dispensing tip of the dispenser and discharges the pumped medicament and other substances therefrom.

  Referring to FIG. 4, the piston 56 is durable, such as a plastic material, and can be constructed of a moldable material, preferably the material is suitable for use in conjunction with a drug. A suitable material is low concentration polyethylene. The piston 56 has a base part 64, an extension part 66 extending from the base part 64, and a central hole 68 in fluid communication with the fluid main chamber 55. The base portion 64 is generally disc-shaped on the outside, and is installed at an inner interval with respect to the connection flange 70, the annular mounting portion 72, the first annular groove 74, and the first annular groove, and the central hole 68. And a second annular groove 76 that surrounds the inlet end. The connecting flange 70 is configured to engage a vial 52 (FIG. 2) that defines a suitably sized mounting flange 78, such as in the form of a snap lock. As shown in FIG. 2, the mounting portion 72 and the first annular groove 74 receive an annular flange 80 and a rib 82 of a pump cover 62 (described later in detail) made of a flexible material, respectively. The fluid main chamber 55 is sealed. As further shown in FIG. 2, when the piston 56 is incorporated into the vial 52, the second annular groove 76 is adjacent to the fluid main chamber 55. The second annular groove 76 thereby functions as a trapping area for receiving bubbles that inadvertently enter the fluid main chamber and prevents the bubbles from entering the central hole 68.

  As best shown in FIG. 4, the extension 66 has an annular groove 84, a laterally extending hole 86, and a termination defining a receptacle 88. The annular groove 84 is configured to receive a seal 90 (FIG. 2), such as an O-ring, for sealing the piston that contacts the slide 60. The laterally extending hole 86 is in fluid communication with the central hole 68 and its end is located near the annular inner surface 92 of the slide 60 (FIG. 3). As shown in FIG. 4, the receiving portion 88 includes an annular wall 94, a tapered portion 95 extending between the annular wall 94 and the hole 86, and a piston surface 96 for stopping the movement of the nozzle 58. The situation will be described in detail later with reference to FIGS. The annular wall 94 increases in outer diameter towards the end of the piston and slidably engages the annular inner surface 92 of the slide 60. This will be described in detail later with reference to FIG.

  As shown in FIG. 3, the piston 56 further has two hook portions 97 that are generally symmetrically disposed, each of the hook portions 97 defining an individual slot 99 with the outer surface 101 of the piston 56. As will be described in detail with reference to FIG. 7, the slide 60 is reciprocally installed in the slot 99, and when the pump is operated, the piston moves relatively in the slide.

  Next, in FIG. 5 and FIG. 6, the nozzle 58 is made of a suitably durable, moldable, somewhat flexible material such as a plastic material (a shape in which the nozzle and body are fabricated as a single unit). For example, both of which are trademarks of VELEX and LEXAN owned by the General Electric Company of Pittsfield, Massachusetts. What is sold. The nozzle 58 is preferably molded as a single piece, and includes a conical body portion 98 having a truncated tip, and a disk portion 100 positioned coaxially with the conical portion and extending radially therefrom. It can be seen that the conical portion 98 and the disc portion 100 can be molded either integrally or individually. The conical portion 98 has a tapered outer surface 102, a central hole 104 that is halfway, and an engaging portion 106. The middle hole 104 ends halfway with a lever wall 108 sized and shaped so that the tapered outer surface 102 can deflect in the direction of arrow 110. The engagement portion 106 is configured with a receiving portion 88 of the piston 56, as described above with respect to FIG. As shown in FIGS. 2 and 3, when the piston 56 has supplied a predetermined amount and reaches the end of its stroke, the nozzle engagement surface 112 is received in the guide wall 94 and engages with the piston surface 96. Don't move any further. It can be seen that a variable discharge amount holding portion 113 is defined between the engagement surface 112 of the nozzle 58 and the piston surface 96 of the piston 56. As shown in FIG. 3, the maximum stroke volume is defined by the distance that the engagement surface 112 is maximally separated from the piston surface 96.

  As shown in FIG. 6, the disk portion 100 includes an annular mounting portion 114 for fixing the nozzle 58 to the pump cover 62 and the slide 60 (FIGS. 2 and 3), and also allows fluids and other substances to pass therethrough. Slot 116 is provided. The attachment portion 114 has an annular thickened portion 118 and a neck portion 120 located between the pair of annular grooves 122 and 124. As shown in FIGS. 2 and 3, the annular groove 122 is configured to engage the rib 126 of the pump cover 62 (FIG. 8) and the annular slot 124 is the correspondingly shaped distal end 128 of the slide 60 (FIG. 7) is configured to engage. As shown in FIG. 6, the annular groove 124 defines an annular gap 130 that is used, for example, to facilitate the incorporation of the slide 60 into the nozzle 58. The slot 116 is located in the vicinity of the flat portion 132 of the tapered outer surface 102, thereby realizing fluid communication from the variable once discharged amount holding portion 113 through the disk 100 to the tapered outer surface.

  As shown in FIG. 7, the slide 60 defines a tubular body and can be composed of materials similar to those described above for the nozzle 58 (FIGS. 5 and 6). As described above and with reference also to FIG. 2, the slide 60 has an annular inner surface 92, and when the dispenser 10 is assembled, the engagement portion 106 of the piston 56 and the nozzle 58 is located on the annular inner surface 92. Inner surface 92 defines a hole 134 with a small diameter neck 136 between a first transition region 138 that increases in diameter relatively quickly and a second transition region 140 that increases in diameter relatively slowly. Located in. Referring to FIG. 2, while the nozzle 58 and slide 60 move relatively away from the piston 56, the piston annular wall 94 (FIG. 4) seals and engages the second transition region 140 (FIG. 7). In addition, it can be understood that the liquid in the variable once discharged amount holding portion 113 is pushed into the slot 116 at the nozzle tip.

  Referring to FIG. 7 and as previously described with reference to FIGS. 5 and 6, the slide 60 defines a terminal end 128 with an annular thread 142 configured to engage the gap 130 of the nozzle 58. As shown in FIG. 3, the opposite end of the slide 60 defines a flange 144 configured to engage the hook portion 97 of the piston 56.

FIG. 8 is a cross-sectional view of the flexible pump cover 62. The flexible pump cover 62 can be made of any material having durability, elasticity, and flexibility, such as a rubber-like material. Preferably, the pump cover 62 is constructed of a thermoelastic material, such as a styrene butadiene elastomer sold by GLS of Illinois under the KRATON trademark. Other suitable materials include polyvinyl chloride, Santoprene ^™ , butyl rubber. The pump cover 62 includes a mounting portion 146, a bellows portion 148, and a nozzle cover 150 that cooperates with the slot 116 (FIG. 6) to provide a resilient valve, as will be described later in connection with FIG. As described above in connection with FIG. 4, the attachment portion 146 has an annular flange 80 that fits within the attachment groove 72 near the attachment flange 78 (FIG. 2) of the vial 52. As shown in FIG. 8, the rib 82 has a conical shape with a truncated tip corresponding to the shape of the annular groove 74 (FIG. 4) of the piston in its cross section. Due to the elasticity of the material of the pump cover 62, the annular flange 80 is slightly larger in size to fit resiliently with the vial 52 and piston 56, thereby sealing the main fluid chamber 55 (FIG. 2) along with the ribs 82. It can be.

  The bellows portion 148 extends between the attachment portion 140 and the nozzle cover 150 and has a plurality of meandering or oppositely curved portions 152, and the meandering portion 152 has a restoring force in a direction substantially parallel to the central axis 154. And either the piston or nozzle away from the other, providing a spring-like force sufficient to return the piston to the top of its stroke when a predetermined amount of drug or other material in the chamber 55 is supplied To function. Referring also to FIGS. 2 and 6, the nozzle cover 150 is dimensioned and configured to be resiliently engaged with the nozzle 58 and the slide 60 when attached, and has an annular rib 126 extending axially from the disk engaging portion 156. . The disk engaging portion 156 is installed between the slide engaging portion 158 and the nozzle body engaging portion 160. Referring also to FIG. 6, the nozzle body engagement portion 160 is configured to engage the tapered outer surface 102 of the nozzle 58, thereby forming a one-way valve that is normally closed therebetween. As seen in FIG. 8, the thickness of the cross section of the nozzle engaging portion 160 gradually decreases from the disk engaging portion 156 in the axial direction toward the supply tip 161. By gradually reducing the cross-sectional thickness of the nozzle engagement portion 160, one formed by a long, annular joint surface between the relatively flexible nozzle engagement portion 160 of the cover and the tapered surface 102 of the nozzle body. Drugs and other substances are easily released through the directional valve, while air and other gases are prevented from passing through the valve to the opposite side. This is due to the teachings of the following patents incorporated herein by reference:

  As shown in FIG. 6, the conical portion 98 defines a tapered outer surface, or valve seat 102. An interference fit between the nozzle cover 150 and the valve seat 102 forms a normally closed valve that opens until a single dose of the substance in the dispenser is delivered. The part or slot 116 is sealed. As shown, the portion of the nozzle cover 150 that contacts the valve seat 102 is preferably tapered so that the thickness is greater near the base of the valve seat, gradually decreases, and becomes thinner near the end of the valve seat. This makes it easier for the valve to open and the substance to flow through it. Further, the axial length of each of the valve seat 102, the nozzle cover 150 and the annular valve opening formed therebetween, ensures that the annular segment of the valve cover is always connected to the valve seat when material is fed through the valve opening. Sufficient to keep in contact. As can be seen, the nozzle cover 150 defines a hole therein, in which the valve seat 102 is received, forming an annular valve that is normally closed at the interface between the valve seat and the valve cover. The diameter (or width) of the valve seat is larger than the diameter (or width) of the hole in the cover, thereby forming an interference fit and normally closed valve opening therebetween. Preferably, the degree of tightness between the valve cover hole and the valve seat decreases in the axial direction of the valve seat from the inside of the dispenser to the outside so that the substance can flow easily through it.

  As one skilled in the art can appreciate based on the teachings of the present application, the one-way valve of the dispenser of the present invention is of various shapes that are currently known or will be known to perform the functions of the valves described herein. For example, copending application 60 / 403,484 filed on August 13, 2002, 10 / 272,577 filed on October 16, 2002, and filed August 13, 2003 No. 10 / 640,500, which may be any of the one-way valve configurations, and these applications are incorporated by reference as part of this application.

  In operation, as previously described with respect to FIGS. 1 and 1A, when the vial 52 moves axially, the piston 56 is moved from the position shown in FIG. 2 to FIG. 3 by actuation of the trigger 28 or other actuator of FIG. Moves to the position shown (or vice versa) so that the fluid passes through the central hole 68 of the piston and the laterally extending hole 86 into the variable single dose holder 113 from the fluid main chamber 55. Be drawn. Next, referring also to FIGS. 6 and 8, as the piston 56 moves in the direction of the nozzle 58 (or vice versa), fluid can flow from the slot 116 (FIG. 6) into the tapered surface 102 and the nozzle body engaging portion 160. In between, it is injected along the flat surface 132 and then outside the nozzle tip. Further details of the pump assembly used in the practice of the present invention can be found in US Pat. Nos. 5,944,702, 5,875,931, and 5,746,728, assigned to the same assignee as the present invention. These patents are incorporated herein by reference in their entirety.

  The advantage of the pump shape according to the illustrated embodiment is that the pumped fluid extends in a direction parallel to the shaft 154 from the variable once discharged amount holding portion 113 as shown by the arrows indicating the fluid flow paths in FIG. A unidirectional direction formed by the interface between the nozzle engaging portion 160 of the cover and the tapered outer surfaces 132, 102 of the nozzle body along the substantially straight path and from the slot 116 over the tapered surface of the engaging portion 106. Flows between valves. This relatively straight and smooth fluid flow path allows the pumped fluid to pass through the nozzle with a relatively small head loss and requires less force to supply the fluid. Thus, precise control over the type of liquid flow discharged from the supply tip is facilitated, as is control over flow rate, spray droplet size, spray pattern, and the like.

  Another advantage of the illustrated pump configuration is that the bellows 148 is sealed with respect to the variable stroke volume retainer 113 so that the drug or other material in the chamber 55 collects in the space between the bellows and the piston or slide. Is prevented. As shown, the O-ring or similar seal 90 forms a fluid tight seal between the piston and the slide and prevents fluid from flowing therethrough into the bellows. Similarly, the fluid tight seal is formed at the joint surface of the cover 62, the nozzle 58 and the slide 60. For example, the joint surface of the cover slide engaging portion 158 and the slide 60, and the joint surface of the annular rib 126 of the cover, There is a fluid tight seal at the annular groove 122 of the nozzle 58.

  Referring now to FIGS. 9 and 9A, the vial 52 is preferably constructed of a suitable rigid and moldable material, such as a rigid polymeric material such as polycarbonate or polyvinyl chloride. Preferably, this material is selected to be compatible with various types of drugs, such as those sold under the Lexan trademark of General Electric Corporation of Pittsfield, Massachusetts. The vial 52 has a tubular shape and an annular connection flange 162 formed at the opposite end of the vial with respect to the fluid main chamber 55, the annular mounting flange 78 described above in connection with FIGS. Is defined. The fluid main chamber 55 is large enough to accommodate a liquid to be supplied, such as a predetermined amount of medicine, along the flexible sac 54 (FIG. 2). This will be described in detail later. The mounting flange 78 includes an annular thread 164 for sealingly mounting the vial 52 with the nozzle cover 62 (FIG. 2) and preventing movement of the cover during use of the dispenser 10. As seen in FIGS. 2 and 3, the attachment portion 146 of the cover 62 is sandwiched between the base 64 of the piston 56 and the rigid vial 52 to form a fluid tight seal.

  As shown in FIG. 9A, the annular connecting portion 162 has a tapered end portion 166 and a peripheral groove 168 provided in the increased diameter portion 170 at a distance from the inside toward the inside. An annular thread 172 is provided to engage the flexible bladder 54 (FIG. 2). As will be described later, the increased diameter portion 170 and the annular thread 172 function to seal the fluid main chamber 55 after the vial 52 is assembled. As will be described later, an annular groove 174 is provided to hold the vial 152 during filling of the fluid main chamber 55.

  Referring now to FIG. 10, the flexible bladder 54 can be constructed of a suitable flexible material and preferably defines barrier properties that prevent the passage of vapor, moisture, or gas. For ease of manufacture, the material is preferably moldable and is compatible with various drugs and other materials that enter the chamber 55. Alternatively, the flexible bladder 54 can be composed of a thermoelastic material, such as a styrene butadiene elastomer sold under the KRATON trademark described above with respect to the pump cover 62. Similarly, materials sold under the VISKAFLEX trademark owned by AES Company, the ALKRYN or HYTREL trademark owned by Dupont Company in Wilmington, Delaware, and the SARLINK trademark owned by DSM Company may be used. . However, these materials are only examples. As those skilled in the art will appreciate from the teachings herein, the flexure sac can be comprised of a number of other materials now known or later known to perform the functions of the flexures disclosed herein.

  In a preferred embodiment of the present invention, the flexible bladder 54 is made of an elastic material as described above and is molded in an expanded state. Therefore, when crushed as described below, the elastic sac tends to spread outward, increasing the pressure of the drug or other liquid in the fluid main chamber 55 as compared to the pressure inside the sac. The great advantage of this pressure differential is that air or other gases or vapors in the inner chamber of the bladder are prevented from entering the bladder or otherwise into the main fluid chamber. As a result, the dispenser of the present invention includes multiple doses, drugs and other materials that do not use preservatives, and such materials that have been sterilized over a long period of storage, storage, or use of the dispenser. It is particularly suitable for keeping in mind. This advantageous feature helps to prevent the ambient conditions of the dispenser from affecting the airless state of the fluid main chamber 55 and prevents air, other gases or vapors from entering the fluid main chamber. prevent.

  The flexible sac 54 is also preferably a barrier that prevents the passage of gas such as air from the flexible sac, so that it can be composed of a single layer of material that has a very low permeability to air. In one embodiment of the invention, the bladder 54 is comprised of a multilayer material. For example, as shown in FIG. 10B, the bladder wall 175 includes an elastomeric first flexible layer 177 that is relatively permeable to air and a relatively impermeable to air, Delaware. It can be a barrier layer 179 such as a metal-deposited MYLAR such as an aluminum and polyester composition sold by Dupont Corporation of Wilmington. The barrier layer 179 can be installed between the upper layer 181 and the lower layer 183 of polyethylene, and can easily adhere the barrier layer to the wall 175 of the sac while maintaining flexibility. Alternatively, the barrier layer 179 may be comprised of polyvinylidene chloride sold under the SARAN trademark owned by Dow Chemical Company of Midland, Michigan. The barrier layer 179 is preferably dimensioned to cover as much of the bladder wall 176 as possible to reduce the passage of air therefrom without interfering with various possibilities of the flexible bladder, as described below. To do. The barrier layer 179 is also preferably placed inside the bladder wall 175. Alternatively, the barrier material may be a butyl rubber-based material such as one used for manufacturing a syringe stopper or one used in the tire industry. As those skilled in the art will appreciate from the teachings of the present application, the flexible sac and barrier materials disclosed herein are merely examples, and others currently known or will be known to perform the functions disclosed herein. Many of these and materials can be used as well.

  Turning again to FIG. 10, the flexible bladder has a tubular shape and has a closed end 176 and an open end 78 in fluid communication with the cavity 180. The bladder 54 defines an outer diameter that is sized to fit within the vial 52 (FIG. 2) when in the expanded state as shown in FIG. As shown in FIGS. 2 and 3, the outer surface of the sac 54 preferably defines substantially the same shape or configuration as the inner surface of the rigid vial 52 so that when the sag expands, these sac are The entire joint surface of the two components is in contact with and in contact with the rigid vial, thereby eliminating the ullage or dead space between these components, from which all of the drug and other substances in chamber 55 are supplied. The pump 50 can be pushed out into the variable discharge amount holding unit 113. In addition, the outer diameter (or width) of the flexible sac when fully inflated is preferably slightly larger than the inner diameter (or corresponding width) of the rigid vial, causing the expanded sac to generate a recovery force toward the vial. Hold at least a slight pressure difference between the chamber 55 on one side of the bladder and the inside of the bladder, thereby allowing air or other gases or vapors to enter the fluid main chamber from the bladder, as described above. Can be prevented.

  As shown in FIGS. 10 and 11, a reinforcing member or rib portion 182 extending in the longitudinal direction is installed along the inner surface 184 and functions to provide a support structure when the bladder 54 is crushed. This will be described in detail later with reference to FIG. To achieve this, the ribs 182 extend axially along the inner surface 184 and are arranged at approximately equal intervals around the inner surface. It can be seen that the present invention includes the rib portion 182 having a configuration other than this and the use of the rib portion in other locations. For example, the rib portion 182 may extend along the inner surface 182 of the closed end 176 of the flexible bladder 54.

  As shown in FIGS. 10 and 10A, the flexible sac 54 includes an annular flange 188 formed at the rear end of the sac and an outer annular ring that is spaced axially inwardly with respect to the flange 188. A lobe 190 and an inner annular lobe 192 disposed between the outer annular lobe 190 and the flange 188. As shown in FIG. 10A, the annular flange 188 defines an annular V-shaped cut on its underside for sealing engagement with the annular thread 172 (FIG. 9A) of the vial 52. Further, the annular flange 188 is large so that the peripheral surface of the annular flange engages the corresponding annular groove 168 (FIG. 9A) of the vial 52, as will be described in detail later, during initial assembly with the vial.

  During storage or storage of the dispenser 10, the material of the flexible bladder 54 flows or moves to even out the tension and compressive force it receives. Creep as used herein refers to a change in the properties of a material such that the resilience and memory of the material are impaired. In particular, when creep occurs, the elastic material is permanently deformed and at least part of its original elasticity is lost. Therefore, during assembly and during filling of the dispenser 10, a low pressure is applied to the cavity 180 of the flexible bladder 54, thereby causing its crushing and elastic deformation, which is the fluid main chamber 55 (FIG. 2). It is held by the pressure of the fluid filled in the. The filled dispenser is then held in a storage location or store or other merchandise shelf for at least 2 to 3 months prior to use, during which time the capsular material creeps, which causes at least some deformation. May occur. In order to properly manage the movement of the material during creep of the flexible bladder 54, the bladder has an outer annular sealing lobe 190, an outer sealing lobe and a flange 188, as shown in FIG. 10A. An inner annular sealing lobe 192 is provided that is axially spaced between, and when creep is caused by an elastomeric or rubber-like material, the pressure between the materials is balanced between the two lobes 190, 192. Consistent fluid tightness. Thereafter, such a mechanical seal is maintained because, as at least one factor, the material lobe is formed by the inner lobe, in which the creep of the material of the outer lobe 190 is the inner lobe. Offset by that of

  As shown in FIG. 10A, the outer annular lobe 190 comprises a first angle portion 190 located on one side of the lobe 192 and a second angle portion 200 placed on the opposite side of the lobe. The first angle portion 98 defines a first acute angle “A” with respect to the central axis 202 that ranges from about 0 ° to about 30 °, more preferably from about 0 ° to about 10 °. Second angle portion 200 defines a second acute angle “B” with respect to axis 202 that ranges from about 0 ° to about 15 °, more preferably from about 0 ° to about 5 °. The first angle A is greater than the second angle B to ensure that the material moves approximately in the direction of arrows 204 and 205 while creep of the material of the flexure body 54 occurs. The flexible bladder is secured axially by an inner annular sealing lobe 192 received in the corresponding annular groove (FIG. 14) of the posterior plug. As shown in FIGS. 2 and 3, when the flexible bladder 54 is fully received in the rigid vial 52, the outer annular lobe 190 is pressed against the smooth inner wall of the vial and the inner annular lobe 192 is Is received in the annular groove 22 (FIG. 14) of the rear stopper, and an annular flange 188 is sandwiched between the rear stopper and the annular thread 172 of the rigid vial. In this manner, the inner annular sealing lobe 192 functions as a material tank for the outer annular sealing lobe 190, and the material is generally removed from the outer lobe 190 by an axially offset lobe, as indicated by arrows 204,205. To 192 and from both lobes generally toward the annular flange 188. As a result, the flow of material is consistently directed to the inner sealing lobe 192 or annular flange 188, thereby ensuring fluid tightness between the flexible sac, rigid vial, and posterior plug regardless of the degree of sac material creep. Is preserved. As shown, the shape and relative position of the outer annular lobe 190 facilitates directing the force in the sac, and thus the material, in the direction of arrows 204 and 205, as described above. The fluid tightness can be maintained throughout the period of use.

  As shown in FIG. 11, the flexible sac 54 preferably includes at least one surface cut 206 that allows the sac to collapse from a tubular shape to a predetermined collapsed shape and is controlled. As a result, the cavity 180 defined by the inside of the bladder is substantially eliminated. In the illustrated embodiment, the flexible sac has three surface cuts 206 that are substantially equally spaced from each other on the inner surface 184 of the sac. As shown, the cuts 206 are each disposed at approximately equal intervals between adjacent elongated ribs 182. The cut 206 is depicted in the figure in the form of a gap or a fissure that ends in a substantially flat central portion (no reference number) in the cross section. As shown, the surface cut 206 causes the bladder to collapse or fold around each of the elongated ribs 182, thereby providing three folds or legs that are approximately 120 ° apart from each other in the collapsed state. Is formed. As will be appreciated by those skilled in the art from the disclosure of the present application, and as described in another embodiment below, a predetermined shape similar to the predetermined crush shape formed by the cuts and the elongated ribs as described above is used. Many other structures or shapes can be employed as well to collapse the sac.

  Turning now to FIG. 12, a simplified cross-sectional view of the outer wall 208 'of the flexible bladder 54' is shown. The flexible bladder 54 'can be crushed in the direction of arrow 210' from the expanded position indicated by the solid line near the outer wall 77 of the vial 52 (FIG. 9) to the collapsed position indicated by the dashed line. Since the flexible bladder 54 'is functionally similar to the flexible bladder 54, similar elements are given similar reference numbers with the symbol "'". However, it can be seen that there is some structural difference between the flexible bladder 54 and the flexible bladder 54 '. For example, the cut 206 'is depicted as being reversed with respect to the cut 206 and substantially covers the entire cross-sectional thickness (t') of the wall 208 '. The cut 206 'is depicted in a generally arcuate shape, but it is anticipated that other shapes such as the cut 206 can be used provided that they perform the functions described below. It can also be envisaged that the rib 182 'defines a mounting slot 209' for receiving a correspondingly shaped part (not shown) in the vial.

Both cuts 206, 206 ′ serve to reduce the length of the portion of the wall 208 ′ necessary to collapse the flexible bladders 54, 54 ′. Although this role has been described with respect to the embodiment of FIG. 12, this description applies equally to the embodiment of FIG. As shown in FIG. 12, the wall 208 ′ has a plurality of walls 212 ′ extending between each cut 206 ′ and an adjacent rib 182 ′, as shown by the solid lines. Each wall 212 ′ draws an arc when the bladder 54 ′ expands. While the sac 54 'collapses in the direction of the arrow 210', the wall 212 'becomes substantially linear, draws a chord shown by the chain line, and operates in reverse as shown by the dashed line. Therefore, as shown in the figure, the length L ₁ of the cut 206 ′ indicated by the solid line is shortened to the length L ₂ indicated by the chain line, and the arc 212 ′ can freely move in the direction of the arrow 210 ′. . When the flexible sac 54 'is completely crushed, the sac expands and the wall 212' can freely move in the direction opposite to the arrow 210 '.

As shown in FIGS. 13 and 14, the flexible bladder has a posterior stopper 214 configured to couple with the open end 178 (FIG. 2) of the flexible bladder 54, between the posterior stopper and the rigid vial 52. The flexible sac 54 installed in is sealed. The rear plug 214 can be made of a durable material having a suitable strength, such as a polymer material such as polyethylene, and is preferably made of Lexan ^™ having a stress-resistant property or a similar polycarbonate. To do. The rear plug 214 has a terminal wall 216 and a side wall 218, which, as best seen in FIG. 14A, preferably have a tapered portion 220 that gradually increases in diameter toward the rear end of the plug, and a tip. An annular groove 222 spaced apart toward the back of the detail 220, a step 224, and a plurality of outwardly projecting projections spaced angularly with respect to each other about the axis of the plug It includes a tab 226 (or a bump that may be easy to manufacture) and a hole 228 extending along the side wall that allows fluid communication between the internal chamber 180 of the bladder and the atmosphere. The tapered portion 220 increases in diameter, making it easier to incorporate the plug 214 into the flexible bladder 54 (FIG. 2) and defining an annular space 230 (FIG. 2) between the stopper and the adjacent surface of the flexible bladder. As described above, and as shown in FIGS. 2 and 3, the annular groove 222 is configured to receive the inner annular lobe 192 (FIG. 10), and the step portion 224 is against the annular thread 172 of the rigid vial. The annular flange 188 of the flexible bladder 54 is sandwiched. As best seen in FIGS. 13 and 14, the safety sealing tabs 226 protrude upward and outward from the step 224 and are angularly spaced relative to each other about the axis of the plug. The sealing tab 226 is installed to lock the stopper 214 to the vial 52 (FIG. 2) and, when pressed against the annular flange 188 of the bladder, snaps into the annular groove 168 (FIG. 9). It is configured to fit and is thereby hermetically sealed. In addition, the sealing tab 226 is typically tapered outwardly, as shown in FIG. 14A, so that the tab can easily fit into the annular groove 168 of the vial. However, since the tab cannot be taken out of the groove in the opposite direction, it also prevents mischief to the sealed portion. The hole 228 allows fluid communication between the annular space 230, the chamber 180 (FIG. 2) and the atmosphere, and is depicted in a generally rectangular shape. However, it will be understood that circles and other different shapes can be utilized as long as a sufficient amount of air can pass to fill the internal chamber 180 of the flexible bladder 54.

  10 and 10A, the flexible bladder 54 is also preferably axially spaced below the sealing lobes 190, 192 to control the air flow between the inner chamber 180 of the bladder and the atmosphere. An installed bidirectional valve 234 is provided. The valve 234 includes an annular operator 235 that protrudes inwardly from the inner wall of the bladder and is substantially thread-shaped in cross section. As shown in FIGS. 2 and 3, the terminal end of the annular operator 235 engages with an annular surface 232 formed in the base of the posterior plug 214 between the annular space 220 and the internal chamber 180 of the bladder. To position. The flexure bladder 54 further defines a plurality of support ridges 236 that are axially spaced in the vicinity of the annular operator 235 and that are angularly spaced relative to each other about the shaft 202. The end surface of each ridge 236 is spaced inwardly with respect to the end of the annular operator 235 so that the operator 235 engages the rear plug and the interface between the operator and the rear plug is sealed, At the same time, a sufficient radial space is ensured between the posterior plug and the flexible bladder so that the operator 235 can move in either direction. Thus, as can be seen, the annular wall 232 of the operator 235 and the rear plug is such that fluid can pass when the pressure difference across the valve is sufficient to deflect the operator axially. Form a bidirectional valve. It will be appreciated that the operator's stiffness is set to allow fluid to pass through when the pressure differential exceeds a predetermined pressure limit. Thus, the great advantage of the valve 234 is that it retains a relatively stable microatmosphere in the inner chamber 180 of the flexible bladder 54, air between the microatmosphere in the bladder and the atmosphere, other gases or It is to prevent the normal exchange of steam. For example, when a drug or other substance is supplied from the fluid main chamber 55 by the valve 234, air is drawn into the chamber 180, which causes the bladder to expand and fill the supplied drug space. However, valve 234 also prevents air and steam from flowing freely between the microatmosphere and the atmosphere. Thus, the microatmosphere in the chamber 180 defines a different pressure or humidity level compared to the atmosphere. The great advantage of this feature is that it insulates the microatmosphere from changes in atmospheric pressure or humidity, thereby maintaining a relatively stable pressure and humidity level in the microatmosphere, so that the air or vapor can be encapsulated. The passage from the body wall to the fluid main chamber is prevented.

  In FIG. 15A to FIG. 15C, a state where the dispenser is full, a state where the contents are half, and an empty state are shown. In FIG. 15A, the fluid main chamber 55 is filled with, for example, a drug (not shown) that the pump assembly 50 pumps out of the nozzle 58. Therefore, the sac 54 is drawn in a state in which the sac 54 is crushed. In FIG. 15B, the flexible sac 54 is in an expanded state, and thus the sac is expanded to move a volume of medicine supplied from the fluid main chamber 55. To accomplish this, air has already passed through valve 234 and into the inner chamber 180 of the sac in the direction of arrow 240. In FIG. 15C, the dispenser 10 is depicted empty. As shown, the bladder 54 is fully inflated with respect to the rigid vial wall 77, substantially matching the shape of the rigid vial, eliminating ullage or dead space, drugs and other materials therein. Are all discharged to the pump 50.

  Turning now to FIGS. 16A-16C, an initial assembly of the dispenser 10 for sterilization, such as by irradiation with an energy beam, is shown in FIG. 16A. In particular, the posterior plug 214 is attached to the flexible bladder 54, and the stopper and the flexible bladder are partially inserted into the vial 52. Referring now to FIGS. 9A and 10, the flange 188 of the flexible bladder 54 is positioned in the annular groove 168 of the vial 52 when in the partially inserted position, thereby causing the capsule and vial In the meantime, an airtight, but not tamper-proof sealed part is formed. In this state, the dispenser 10 can be sterilized or transported in a sealed state prior to filling the drug or other material to be placed therein.

  The state of filling of the dispenser 10 is schematically depicted in FIG. 16B. Here, the flexible sac 54 and the stopper 214 are separated from the vial 52 and reach the fluid main chamber 55 for filling. As can be seen, the annular flange 188 of the sac can be pulled back and removed from the annular groove 168 of the vial and the vial opened to reach the fluid main chamber 55. Preferably, this operation transports the sterilized dispenser by a sterilization transport port, for example, commonly assigned US Pat. Nos. 5,641,004 and 5,816, incorporated herein by reference. , 772 by filling the dispenser in a sterilizing and filling apparatus of the type disclosed in US Pat. In filling, the inner chamber 180 of the sac is evacuated to collapse the sac, and drugs and other substances contained therein are introduced into the fluid main chamber 55. In some embodiments, the fluid main chamber 55 is overfilled, that is, the amount of drug supplied to the chamber exceeds the amount the chamber can accommodate with the bladder and plug inserted. This eliminates the possibility of air entering the fluid main chamber when the bladder 54 and the rear plug 214 are inserted (that is, the fluid main chamber is filled only with a drug or other substance). ).

  As shown in FIG. 16C, when the fluid main chamber 5 is filled with a drug or other substance to be contained therein, the flexible sac and posterior plug assembly moves into the rigid vial, in FIG. 9A. As best seen, the flexure flange 188 of the bladder moves to engage the annular thread 172 and the posterior stopper is pressed inward so that the sealing tab 226 is in place within the annular groove 168 of the vial. An airtight sealing part that fits and is prevented by tampering is realized. In this state, the dispenser 10 can be attached to the ophthalmic treatment device described above or any other suitable device for supplying medication or other fluids, such as a nasal inhaler.

  In some embodiments, it may be desirable to utilize a vacuum to “capture” drug or other material overflowing from the vial during insertion of the bladder and posterior plug. This is especially true if the fluid main chamber 55 overflows before inserting the bladder and posterior plug in order to eliminate the possibility of air entering the main chamber after inserting the bladder and posterior stopper. Without vacuum, any excess drug or other material will overflow the vial when the capsule and posterior plug are inserted.

  In FIGS. 17-20, another embodiment of the dispenser of the present invention is indicated generally by the reference numeral 310. Since the dispenser 310 is substantially the same as the dispenser 10 described above, similar reference numbers starting with the number “3”, or starting with “4” instead of “1”, or starting with “5” instead of “2” are , Used to indicate similar elements. The main differences between the dispenser 310 and the dispenser 10 are that (i) the rigid vial 352 and the piston 356 are formed as an integral component, and (ii) the nozzle 358 and the slide 360 are formed as an integral component. (Iii) the flexible sac 354 defines a smooth cylindrical shape without any cuts or ribs, and (iv) the rear plug 514 has a flexible squeezed shape to a predetermined collapsed shape. And a plurality of inwardly projecting legs 538 for controlling crushing.

  As shown in FIGS. 21-23, the posterior plug 514 defines a framework within the inner chamber 480 of the flexible bladder 354 that defines a framework for controlling the collapse of the bladder into a predetermined collapsed shape. A plurality of legs 538 that protrude and are axially long are defined. As shown in FIG. 21, the illustrated embodiment according to the present invention has three legs 538 that are angularly spaced about 120 ° relative to each other about the axis of the posterior plug. Each leg defines a generally flat side 540 that lies in each plane that intersects the axis of the posterior stopper and extends radially between the axis of the stopper and the inner wall of the rigid vial. As seen in FIG. 19, the radial edge 542 of each leg is radially spaced inward with respect to the inner wall of the rigid vial so that the flexure sac is in the radial direction of the leg. Can move freely between the rim and the vial. As shown in FIGS. 19 and 20, the legs 538 are axially directed to the inner chamber 480 of the flexible sac by a distance sufficient to allow the legs to control the sac to collapse into a predetermined collapsed state. It extends to. In the illustrated embodiment, each leg 538 extends along at least about half the length of the bladder axis. As shown in FIG. 24, in a predetermined collapsed state, the flexible bladder 354 is engaged with the outer surface of the leg 538, thereby filling the fluid main chamber 355 with a drug or other substance. Next, as shown in FIG. 25, when all the medicine and other substances are supplied from the fluid main chamber 355, the sac expands outwardly away from the legs 538 due to the recoverability of the flexible sac 354. Typically, as shown in FIGS. 19 and 20, when fully inflated, the flexible bladder 354 engages the inner wall of the rigid vial, thereby eliminating ullage or dead space. All of the drugs and other substances in the fluid main chamber 34 are supplied from there.

  As described above, the flexible bladder 538 is preferably made of an elastomer or other rubber having a relatively low permeability such as butyl sulfide rubber. Such rubbers are currently preferred for such applications because of their proven stability or compatibility with various drugs such as pharmaceuticals and vaccines and other substances. In the presently preferred embodiment, the flexible sac 354 is shaped in an expanded state, and when crushed, the resilience of the sac tends to cause the sac to tend to move outwardly to its expanded state. is there. The resilience in the sac exerts pressure on the liquid in the fluid main chamber 355, and thus the fluid main chamber 355 is at a higher pressure compared to the sac inner chamber 480. As a result, the pressure differential prevents air or other gases or vapors from entering the fluid main chamber either through the flexible bladder or rigid vial or otherwise. As such, the material or shape of the bladder is preferably selected to maintain a sufficient pressure differential to prevent entry of air or other gases or vapors into the fluid main chamber under various atmospheric conditions. The As noted above, the preferred rubber material for the flexible bladder disclosed herein is only an example, and many other materials that are currently known or will be known to perform the function of the flexible bladder can be used as well. .

  As shown in FIGS. 26 and 27, the spaced ridges 236 described above in connection with the flexible bladder 54 of FIG. 10A depend on the material of construction of the flexible bladder 354 and other structural features. And become unnecessary. Further, the shape of the outer annular lobe may be different from that depicted in the figure in connection with the bladder of FIG. 10A. As shown in FIG. 27, the outer annular lobe 490 is defined by an annular ridge or thickening, and the tapered surface 498 is between the lobe or annular ridge 490 and the outer peripheral surface of the flexible bladder 354. Extends radially inward. As shown in FIGS. 19 and 20, the annular ridge 490 is compressed against the inner surface of the rigid vial 352 in an axial direction that is secured within the annular groove 522 (FIG. 23) of the rear end cap. In combination with an offset inner annular lobe 492, the creep of the flexible bladder material occurs or the material flows in the direction of arrows 504, 505 in FIG. 27, resulting in the flexible bladder, posterior plug, rigid vial. Is consistently airtight. In this way, the end seal of the flexible sac is radially compressed in the axially offset lobe between the posterior stopper and the rigid vial and axially compressed by the flange between the posterior stopper and the rigid vial. Is done.

  As representatively shown in FIG. 22, the posterior plug 514 defines three holes 528 that are approximately equally spaced with respect to each other about the axis of the plug. Further, instead of defining the sealing tab 226 described above with respect to FIG. 14, the posterior stopper 514 projects outward from the peripheral surface of the posterior stopper and is dimensioned to snap into the annular groove 168 (FIG. 30) of the rigid vial. An annular lobe 526 is defined. The dispenser 310 can be sterilized, provisionally closed, reopened, and filled in a manner similar to that described above with respect to FIGS. 16A-16C.

  As shown in FIGS. 28 and 29, the nozzle 358 and the slide 360 are integrally formed with each other. One advantage of such a unitary structure when compared to the separate nozzle and slide described above for the previous embodiment is that the unitary structure generally has lower manufacturing and assembly costs, and that there are fewer seal points between components, This improves the overall reliability of the dispenser.

  As shown in FIGS. 30 and 31, the piston 356 and the rigid vial 352 can also be formed integrally with each other. As with the monolithic nozzle and slide described above, one advantage of such a monolithic structure compared to the separate piston and slide previously described for the previous embodiment is that the monolithic construction generally has lower manufacturing and assembly costs. Low and, moreover, less sealing points between components, thereby improving the overall reliability of the dispenser. In one currently preferred embodiment of the present invention, the monolithic nozzle 358 and slide 360 are constructed of a relatively soft material, and the monolithic piston 356 and vial 352 are constructed of a relatively hard material. . In the operation of the dispenser 310, when the piston 356 is pushed downward and reaches the compression area 436 (FIG. 29) of the slide 360, the slide compression area 436 is pushed outward by the relative hardness and shape of the piston shown in the figure, or A hermetic engagement with the compression region of the slide forms a fluid tight seal between the piston and the slide. As shown in FIG. 30, the tip of the guide wall 394 is chamfered to assist in sliding the piston within the slide.

  By composing the integral nozzle and slide with a relatively soft and flexible material, the compression area 436 of the slide can be bent outward to remove the part from the core pin when molding the part. Can be molded integrally. Preferably, compressed air is injected between the core pin and the inner surface 392 of the slide to facilitate removal of the component from the core pin (not shown).

  As shown in FIGS. 19 and 20, when the flexible bladder 354 is in a fully expanded state or near it, an annular gap “C” is formed between the bladder and the vial. As can be seen, the width of the gap C gradually decreases in the axial direction from the back end cap 514 toward the closed end 476 of the bladder. As can be seen, the gap C begins at about half the length of the capsule axis, and its width is greatest at the curved portion of the capsule between the side wall and the terminal wall 476. The gap C is created by forming a generally cylindrical sidewall of the flexible sac 354 with a draft sufficient to form a gap when the sac is inserted into the rigid vial. The purpose of gradually widening the gap C is to push all the liquid in the fluid main chamber 355 in the direction of the pump 350 so that no fluid pockets are formed in the fluid main chamber that cannot be drained therefrom. That is.

  Typically, as shown in FIGS. 19 and 20, the flexible bladder 354 defines substantially the same shape as the inner surface of the rigid vial 352, except for the slight differences necessary to create the gap C. Once the sac is fully inflated, the sac is adapted to engage closely with the rigid vial. Further, the flexible bladder 354 preferably has an outer diameter (or width) that is at least as large as or greater than the inner diameter (or width) of the chamber 355 of the rigid vial in a fully expanded state. These features, combined with the resiliency of the flexure sac, prevent gas or vapor from entering the fluid main chamber 355 and ensure that substantially all of the liquid in the chamber can be utilized. Become.

  As shown in FIG. 32, the flexure cover 362 defines an annular mounting flange 380 at one end thereof, which is formed in an integral piston and rigid vial (FIGS. 30, 31) and a corresponding annular groove. By receiving at 374, the flexure cover is secured to the piston and vial. In addition, the integral piston and rigid vial define an annular flange 381 in the vicinity of the annular groove 374, which is received in the corresponding annular groove 382 (FIG. 32) of the flexible cover, making the cover more secure to the piston and vial. Fixed.

  Turning to FIG. 33, another embodiment of the dispenser of the present invention is indicated generally by the reference numeral 610. Since the dispenser 610 is substantially the same as the dispenser 310 described above, the number starts with “6” instead of the number “3”, “7” instead of “4”, or “8” instead of “5”. Are used to refer to similar elements. The main difference of the dispenser 610 compared to the dispenser 310 is that the dispenser 610 comprises a resealable sac, whereby in co-pending US patent application Ser. No. 09 / 781,846 filed on Feb. 12, 2001, US Pat. No. 6,604,561, which is assigned to the same assignee as the present invention and fills the sac in a sterilization filling device of the type disclosed in a patent incorporated by reference as a part of this application. It is a point that can be performed.

  As shown in FIG. 33, the flexible bladder 654 has a resealable portion 844 at its closed end 776 that overlaps the closed end 776. In the illustrated embodiment, the flexible bladder 354 is formed of a first material that is compatible with a predetermined drug or other substance that is placed in the fluid main chamber 655, and on the outer side thereof, the flexible bladder 354 is placed in the fluid main chamber. Defining a drug exposed surface that will be exposed to or in contact with the drug or other substance. The resealable portion 844 can be penetrated by a needle or other filling member to introduce a predetermined drug or other substance into the fluid main chamber through the flexible bladder. Since the penetrable region of the flexible sac is formed of sulfurized rubber, it responds to the application of thermal energy and is substantially impermeable. In contrast, the penetrable region of the resealable portion 844 becomes permeable when heat energy is applied, so that the penetrable region of the resealable portion is airtight when the needle or other filling member is removed therefrom. Sealed. In the illustrated embodiment, the resealable portion 844 is insert molded over the rubber sac while the thermoplastic resealable layer is bonded to the underlying rubber layer. If necessary, a mechanical anchoring device well known to those skilled in the art can be used to help adhere the resealable portion to the end wall of the flexible bladder.

Resealable member 844 is preferably a polymer material sold under the trademark KRATON® by GLS and a low density polyethylene such as polyethylene sold under the trademark ENGAGE ^™ or EXACT ^™ by Dow Chemical Co. It is composed of a recoverable polymer material represented by a mixture of An important feature of the resealable member 844 is that it is resealed after insertion of a needle, syringe or similar infusion member into the resealable member to form a hermetic seal. Preferably, the resealable member can be sealed by heating the area drilled with a needle by the methods described in the above-mentioned co-pending patent application, well known to those skilled in the art. One advantage of the above blended polymer is that the extent to which drugs and other substances are absorbed into the polymer is known to be as low as possible compared to KRATON® itself.

  As shown in FIG. 33, the back plug 514 is formed therein and defines a fill hole 846 that overlaps the close-closeable member 844. 33, a double lumen needle or similar infusion member 848 reciprocates within the fill hole 846 as indicated by the dashed line in FIG. 33, and the closed end of the resealable member 844 and the flexible sac beneath it. 776 is penetrated. The infusion member 848 is coupled in fluid communication with a source of drug or other material (not shown) contained within the fluid main chamber 655 and is operative to fill the chamber with the drug or other material. When the filling of the chamber is completed, the flexible sac 654 is crushed into a predetermined crushing state as described above, and the needle is extracted. If desired, the internal chamber 780 of the flexible bladder may be evacuated during filling to help collapse the bladder. Upon removal of the needle, a laser or other energy source (not shown) applies a laser beam to the penetrating region of the resealable member, sealing the needle hole in the manner described in the above-mentioned co-pending patent application, thereby Drugs and other substances therein are kept sterilized and sealed. The fill hole 846 can be sealed using a cap 850 (shown in broken lines) to keep the inner chamber 780 of the flexure bag sealed.

  In certain embodiments of the present invention, at least a portion of the resealable portion 844 is formed of a thermoplastic material that defines a needle penetration region that can be penetrated by a needle to form a needle hole and has a predetermined wavelength. Can be sealed with heat so that the needle hole can be sealed. In another embodiment of the present invention, the entire resealable portion 844 is formed of a thermoplastic material. In another embodiment of the present invention, the upper overlapping portion of the resealable portion is formed of a permeable thermoplastic material, and the lower overlapping portion of the resealable portion is of an impermeable material such as sulfurized rubber. It is formed. Preferably, each thermoplastic portion or body has (i) a predetermined wall thickness in its axial direction and (ii) a light beam that substantially absorbs a laser beam of a predetermined wavelength and passes through the predetermined wall thickness. (Iii) a laser beam of a predetermined wavelength and intensity for a predetermined time without substantially burning the needle penetration region (ie, the molecule of the material). Define a predetermined color and opacity that seals the needle hole formed in the needle penetration region (without irreversibly changing the structure or chemical properties). In certain embodiments, the predetermined time is about 2 seconds, preferably about 1.5 seconds or less, and most preferably about 1 second or less. In this embodiment, the predetermined wavelength of the laser beam is about 980 nm, and the predetermined intensity of each laser is preferably about 30 watts, most preferably about 10 watts or less, or about 8 watts to about 10 watts. In this embodiment, the predetermined color of the material is also gray, and the predetermined opacity is a dark gray colorant added to the material of the resealable portion in the range of about 0.3% to about 0.6% by weight. Is defined by

  Further, the thermoplastic material is preferably a first material that is a styrene block copolymer represented by a material sold under the KRATON or DYNAFLEX trademark, and preferably a material sold under the ENGAGE or EXACT trademark. A mixture of second materials that are olefins to be produced. In one embodiment, the first and second materials are mixed in a range of about 50:50 by weight to about 95: 5 by weight (first material: second material). In an example of such an embodiment, the mixing of the first and second materials is about 50:50 by weight. The advantage of such a mixture compared to the case of only the first material is that the moisture or vapor barrier properties are improved, thus improving the shelf life of the product, improving the heat sealing properties, reducing the coefficient of friction, molding And the mold flow rate is improved and the hysteresis loss is reduced. As those skilled in the art will appreciate from the teachings herein, these numbers and materials are merely examples and can be varied as desired or as needed in a particular system.

  34A-34C illustrate an ophthalmic treatment device 908 according to another aspect of the present invention. As will be apparent from the description below, the treatment device 908 is similar in many respects to the treatment device 8 (FIG. 1B).

  Referring to FIG. 34A, the treatment device 908 includes a housing 912, an eye cover 916, and a trigger 918. The housing 912 has a first end 919 and a second end 920. The eye cover 916 includes wings 923A and 923B that are pivotally supported on the first end 919 of the housing 912. An elongated, trigger 918 having finger grooves 928 is pivotally supported on the second end 920 of the housing 912. The housing 912 generally defines an inner cavity (details of the inner cavity are shown in FIG. 37).

  The device 98 further includes a heel retainer 936 that is pivoted to a first end 919 of the housing 912 (ie, the same end of the housing as the eye cover 916 is connected). The finger part 937 (FIG. 34C) with an empty space is provided.

  Next, referring to FIGS. 34B and 34C, the housing 912 has two portions 939 and 941. A first portion 939 of the housing (hereinafter referred to as “main part” 939) is substantially U-shaped, and has three side walls: a first side wall 943, a second side wall 945, and a third side wall 947. The second portion 941 (hereinafter referred to as “cover portion” 941) is substantially L-shaped and defines a fourth side wall 949 and a fifth side wall 951 (the fifth side wall is referred to as a bottom wall in the present application). One end of the cover portion 941 is pivotally supported on the upper region of the main portion 939, which will be described later. The other end of the cover portion 941 has a protrusion 953 configured to engage the main portion 939. Due to the engagement, the main portion 939 is locked to the cover portion 941 and is in a “closed state” (as illustrated), thereby concealing the interior of the housing 912. By pressing the protrusions 953 in the direction of each other, the protrusions 953 are disengaged from the main part 939, whereby one or both of the first part and the cover part are free to pivot (relative to each other). An “open” state exposes the inner cavity generally defined by the housing 912 (see FIGS. 35A, 35B, and 37).

  The protrusion tip of the cover portion 941 extends to a region between the finger portions 937 (FIG. 34C) with a space between the collar holders 936. The interval between the finger portions 937 is set to a sufficient width so that the heel presser 936 and the cover portion 941 can pivot without being disturbed by the opponent.

  FIGS. 35A-B show the treatment device 908 with the housing 912 open, and the cartridge 957 is visible according to one aspect of the present invention. The cartridge 957 is used for storage and supply of drugs (or other substances). FIG. 36 is an enlarged view of a portion of the treatment device 908, showing the cartridge 957 and the cover portion 941 of the housing 912 in more detail.

  FIG. 37 is a partially exploded perspective view of the ophthalmic treatment apparatus 908, showing the cartridge 957 and the cover portion 941 of the housing 912 in more detail.

  36 and 37, the cartridge 957 includes a case 959, a nozzle 1058, and an actuator 963. It can be seen that the case 959 has a front region 965, an intermediate region 967, and a rear region 969 (FIG. 36). The front region 965 has a truncated conical shape. The middle region and the rear regions 967, 969 are substantially cylindrical, but have two flat (ie, substantially planar) sidewalls 971. Note that only one of the flat side walls is shown. The other flat side wall is on the opposite side of the cartridge 957. Providing a flat sidewall reduces the width 973 of the cartridge 957, which allows the cartridge to fit into the inner cavity of the housing. The diameter of the rear region 969 is slightly larger than the diameter of the intermediate region 967. The front region 965 of the case has a perforated wall 975 that receives the tip of the nozzle 1068 and is in fluid communication with the fluid path exiting the nozzle 1068. Further, the protrusions 977 extend radially from the front region of the case 959. As will be described later, the protrusion 977 is adjusted to engage with the function on the cover portion 941 of the housing 912 or to engage with the eaves presser when used without the housing 912.

  In this embodiment, the case is divided in half and each case is integrally formed. The two halves are finally joined during manufacture of the cartridge.

  The actuator 963 has a lever 979, and one end of the lever is pivotally supported on the front region of the case 957 by a hinge 981. The other end of the lever 979 extends into an opening in the rear region 969 of the case 957. In the present embodiment, the lever 979 is formed to have a radius “γ”.

  The cartridge 957 is adjusted to be inserted into the cover portion 941 before the treatment device 908 is used. When the medicine in the cartridge is empty, the cartridge 957 can be removed from the cover portion 941 and replaced with another cartridge. In this embodiment, the cartridge is self-contained. Furthermore, the cartridge is a substantially sealed unit, and the opening on the outer surface of the cartridge (except for the drug flow path installed through the one-way valve of the nozzle) has substantially no seal. Does not exist.

  For this purpose, the cover portion 941 has walls 983, 985 and receiving surfaces 987, 989 that define a pedestal extending in the longitudinal direction for receiving the cartridge 957. A longitudinal rib 991 and a transverse rib 993 installed inside the cover portion 941 further define a pedestal for the cartridge 957 and cooperate with the walls 983, 985 and the receiving surfaces 987, 989; Position cartridge 957 correctly. The wall limits the lateral movement of the cartridge 957. The receiving surfaces 987, 989 limit the movement in the axial direction. Further, each of the walls has an opening 995 that cooperates with each protrusion 977 on the cartridge 957 to releasably hold the cartridge 957 on the cover portion 941 and further cover the cartridge 957. Position with respect to portion 941 and housing 012. The width of the cover portion 941 is as small as possible to fit between the first and third side walls 943, 947 of the main portion 939 of the housing 912. The receiving surface 989 includes a slot 997 in fluid communication with the flow path exiting the nozzle 1068.

  FIG. 38 is a partially removed side view of one embodiment of the cartridge of FIG. 357. FIG. In this embodiment, the cartridge 957 includes a pump assembly 1050, a rigid vial 1052, a flexible bladder 1054, a piston 1056, a nozzle 1058, a pump cover 1062, a nozzle cover 1150, a cavity 1180, and a rear plug 1214. And a valve 1234, which are the pump assembly 350, rigid vial 352, flexible bladder 354, piston 356, nozzle 358, slide 360, pump cover 362, nozzle cover 450, cavity 480 described above with respect to FIGS. This is the same as the rear plug 514 and the valve 534.

  Hereinafter, reference numbers beginning with “10” instead of the number “3” indicate similar elements. Similarly, reference numbers starting with “11” instead of the number “4” indicate similar elements, and reference numbers starting with “12” instead of “5” indicate similar elements. For example, the posterior plug 1214 includes a plurality of inwardly projecting legs 1238 for controlling the flexible bladder to collapse into a predetermined collapsed shape. The rigid vial 1052 has a peripheral groove 1168 and has an annular thread 1172 for engaging the flexible bladder 1054.

  However, there are three major differences that should be noted. First, the rigid vial 352 has an enlarged portion and an annular thread (see the enlarged portion 170 and the annular thread 172 (FIG. 9A)). However, in this embodiment, the vial 1052 has only a portion of the increased diameter portion 1300 (FIGS. 39A and 39B) and only a portion of the annular thread 1301 (FIGS. 39A and 39B). This is because the vial 1052 has a flat side 1302 (FIGS. 39A, 39B), which reduces the width of the vial, thereby allowing the vial 1052 to fit within the inner cavity defined by the case 959. It is. As described above, the case 959 has a flat side wall 971 (FIGS. 35-37) to fit within the inner cavity defined by the housing 912. Although not shown in the figure, the flat side wall 1302 (FIGS. 39A, 39B) of the vial 1052 coincides with or contacts the flat side wall 971 (FIGS. 35-37) of the casing 959 along the circumference. . Second, the slide 1060 has a neck 1303 that is approximately 50% shorter than the neck of the slide 360 (see neck 136 (FIG. 7)). This is so that the treatment device delivers about half of the dose delivered by the device of FIGS. Third, the length of the piston 1056 is shorter than the length of the piston 356 in order to place a shorter neck on the slide 1060.

  It should be noted that a single dose can be precisely controlled by controlling the volume defined by the neck 1303. 4 and 7, when the annular wall 94 (FIG. 4) of the piston 56 (FIG. 4) reaches the neck 1303 of the slide 1060, the annular wall 94 forms a seal, which This is because the backflow to the main chamber 55 is prevented, and as a result, the amount of medicine trapped in the neck 1303 of the slide 1060 determines the amount of medicine discharged from the nozzle. Thus, for example, in some embodiments, the dosage can be precisely 10 microliters (μl). However, as those skilled in the art will appreciate from the teachings herein, the dosage is precisely controlled, or is required for a particular application, or otherwise desired, such as 15, 20, 25, 30, 35 or 40 microliters. Can be set to virtually any dose, including other doses such as Thus, the major advantages of the presently preferred embodiments of the present invention are, for example, to maximize the pharmacological benefits of a particular drug, or approximately the same as the volume that can be received and retained in the conjunctival sac. The dose can be precisely controlled to set (or correspond to).

  The cartridge 957 further has a spring 1304. The spring 1304 is installed between the outer surface of the rear wall of the rear plug 1214 and the inner surface of the rear wall of the casing 959. A guide 1306 on the rear plug and a longitudinal rib 1308 on the case 959 hold the spring in the desired position. As described below, the spring 1304 provides a force that helps to overcome friction and expel the dose of medication from the cartridge 957 into the eye.

  As described above, one end of the lever 979 is pivotally supported by the case 959 by a hinge. The other end of the lever 979 extends into the opening 982 of the case 959. The case includes a pair of surfaces 1310 and 1312 that seal the end of a lever that extends into the case 959. Of these surfaces, the radially inner surface 1310 seals the radially inner surface 1314 of the lever 979. Out of the pair of surfaces, the outer surface 1312 in the radial direction seals the outer surface 1316 in the radial direction of the lever 79.

  During operation of the cartridge, a radially inner force is applied to the lever 979. This brings the portion 1318 of the lever 979 into contact with the case 959, which causes the lever 979 to straighten, and thus the end of the lever moves toward the rear end of the cartridge, and the portion of the annular thread 1301 of the vial 1052 Engage. The lever continues to move toward the rear end of the cartridge, thereby driving the piston 1056 in the same direction, enabling the pump to operate (as detailed above), and compressing the sprig 1304. As the radial force on the lever 979 increases, the free end of the lever 979 will eventually disengage from the portion of the annular thread 1301, thereby releasing the integral vial 1052 and piston 1056 from the lever 979 force. As a result, the piston 1056 and vial 1052 as a unitary structure are directed toward the front end of the cartridge 957 due to the restoring force or spring-like nature of the pump assembly 1050 (detailed above) and the spring force of the compressed spring 1304. The medicine (other substances) of a predetermined dose is pushed out from the nozzle 1058.

  40A and 40B are views in which a part of the treatment device 908 is removed.

  40C is a cross-sectional view of the ophthalmic treatment device of FIG. 34A. Looking at FIG. 40C, one end of the trigger 918 is pivotally supported on the housing 912 by a pin 1332. The other end 1334 of the trigger 918 is connected to an arm 1336 having a curved surface 1338, and the arm is connected to the end of the heel presser 936 for pivoting the heel presser 936 by actuation of the trigger 918. The trigger 918 further includes a surface 1339 that is adjusted to transmit the received force to the lever 979 of the cartridge 957.

  During use, the eye cover 916 of the treatment device 908 is placed adjacent to the tissue around the eye with the eyelid press 936 against the tissue near the conjunctival sac. When the trigger 918 is squeezed, the eyelid press 936 rotates in the direction of arrow 1340, which moves the tissue near the eye and exposes the conjunctival sac. The rotation of the collar holder 936 is caused by the arm 1336, which opens the cover of the nozzle 1058. At the same time, the surface 1339 of the trigger 918 applies a force to the lever 979 of the cartridge 957, which causes the cartridge to deliver a predetermined dose of medication (other substances) from the nozzle 1058, as described above.

  In some embodiments, the wings 923A, 923B of the eye cover 916 are sufficiently pivotable so that the wings 923A, 923B cover at least a portion of the nozzle 1058 when the device 908 is not in use.

  It should be noted that in this embodiment, the pivot of trigger 918 and the pivot of lever 979 are on the opposite side of the device. That is, the pivot axis of the trigger 918 is located approximately in the rear region of the device 908, and the pivot axis of the lever 979 is located approximately in the front region of the device 99. In some embodiments, the pivot of trigger 918 and the pivot of lever 979 are at substantially opposite ends of the device (eg, the pivot of trigger 918 is at approximately one end and the pivot of lever 979 is at approximately the opposite end. is there). Note that in this embodiment, the trigger 918 and the lever each pivot in the same direction, eg, downward. Of course, other types of actuators and arrangements may be utilized in other embodiments.

  FIG. 41A is a partial cross-sectional side view showing another embodiment of rigid vial 1452, bladder 1454, and posterior plug 1614 in a filled and uncovered state. FIG. 41B is a partial cross-sectional side view showing the rigid vial and sac of FIG. 41A with a lid on. In this embodiment of rigid vial 1452, bladder 1454, and back plug 1614, vacuum capping is not required. The rigid vial 1452, sac 1454, and posterior plug 1614 are similar to the rigid vial 1052, flexible sac 1054, and posterior stopper 1214 described above with respect to FIG. Hereinafter, reference numerals beginning with “14” instead of the number “10” indicate similar elements. Similarly, reference numbers beginning with “15” instead of the number “11” indicate similar elements, reference numbers starting with “16” instead of “12” indicate similar elements, and instead of “13” Reference numbers beginning with “17” indicate similar elements.

  In FIG. 41B, the rigid vial 1052 has a peripheral groove 1568, an increased diameter portion 1700, an annular thread portion 1701, a fluid main chamber 1855, and an annular thread 1872 in the front region of the increased diameter portion 1700. The fluid main chamber 1872 is the same as the fluid main chamber 55 (FIG. 9). The rear plug 1614 has an inwardly projecting leg 1638, an annular rib 1800, and an annular surface 1832. The protruding leg 1638 is similar to the leg 1238 (FIG. 38) for controlling the sac 1454 to collapse into a predetermined collapsed shape. The annular rib 1800 brings the bladder 1454 into intimate contact with the front portion of the increased diameter portion 1700 of the vial 1452, thereby sealing the fluid main chamber 1855. An annular surface 1832, similar to the annular surface 532 (FIG. 19), brings the posterior portion 1900 of the bladder 1454 into intimate contact with the rigid vial 1452, thereby cooperating with the bladder 1454 and the enlarged diameter portion 1700 of the rigid vial 1452. An annular chamber 1834 is defined. As described below, the presence of the annular chamber 1834 helps prevent spillage when capping the rigid vial.

  In FIG. 41A, an example of a method of filling the fluid main chamber 1855 without using vacuum capping is as follows. The main chamber 1855 of the rigid vial 1452 is supplied with a drug (other substance) to be placed therein. The chamber is preferably overfilled. That is, the amount of the medicine supplied to the chamber 1855 is preferably larger than the amount that the chamber 1855 can accommodate with the capsule and the plug inserted. As a result, the fluid main chamber 1855 is filled with only the medicine and other substances when the bladder 1454 and the rear plug 1614 are inserted (that is, air does not enter the fluid main chamber 1855).

  Referring now to FIG. 41B, the flexible sac 1454 and posterior plug 1614 assembly is moved into the rigid vial 1452, the sac 1454 engages the annular thread 1872, the posterior stopper 1614 is pushed inward, Eventually, the annular surface 1872 snaps into the annular groove 1568 of the vial so that the rear portion 1900 of the bladder 1454 is in intimate contact with the rigid vial 1452 to form an airtight seal. This process pushes excess drug or other material out of the main chamber 1855 but does not spill because it is captured by the annular chamber 1834. As a result, there is no need to use a vacuum to capture excess drug. Of course, the main chamber 1855 should not be filled to the extent that excess drug or other material exceeds (ie, overflows) the annular chamber 1834.

  The cartridge 957 is depicted such that the treatment device has a number of features, such as a housing 912, an eye cover 916, a trigger 918, an eyelid retainer 936, etc., but the cartridge is only some of these features. It can also be used for therapeutic devices. For example, in some embodiments, the cartridge 957 is used with a treatment device that does not have a cover to hide the cartridge. Thus, even when installed in the housing, the cartridge is always visible. In other embodiments, the cartridge is used, for example, in a treatment device that does not have an eye cover 196, a trigger 918, and an eyelid retainer 936. Of course, some treatment devices have more features than the treatment device 908.

  Further, although the cartridge 957 is depicted as being used within the therapy device 908, it should be noted that the cartridge 957 can be used alone, that is, without using the rest of the device 908. For example, the user may press the lever of the cartridge with his / her hand. Further, if desired, heel presses and other features can be combined with the cartridge 957 to further assist the user in supplying the medication. The heel presser need not be trigger type like the heel presser 936. An example of a cartridge 957 with one embodiment 1952 of a heel presser is shown in FIG. A cartridge 957 with another embodiment 1954 of a heel presser is shown in FIG. As those skilled in the art will appreciate from the teaching of the present application, the heel presser has various shapes and configurations that are currently known or will be known in the future as performing the various heel presser functions disclosed herein. Can do.

  Further, it should be understood that the cartridge 957 is not limited to the cartridge 957 that is the specific embodiment described above. For example, in certain embodiments, the cartridge may not use an integral pump and vial. In addition, some embodiments use different shaped cases, different actuators, and different storage or supply systems.

  Furthermore, it should be understood that the dispensers and cartridges disclosed herein are not limited to eye treatments or even medical devices.

  42 to 4 illustrate an ophthalmic treatment device 2008 according to another aspect of the present invention. The treatment device 2008 is similar to the treatment device 908 (FIGS. 34 to 40). Unless otherwise noted, reference numbers starting with “20” instead of the number “9” indicate similar elements, reference numbers starting with “21” instead of the number “10” indicate similar elements, and “12 Reference numbers beginning with “23” instead of “” indicate similar elements. However, unless otherwise noted.

  For example, the therapy device 2008 includes a housing 2012, an eye cover 2016, a trigger 2018, and a heel presser 2036, which are the housing 912, eye cover 916, trigger 918, and heel presser 936 (see FIG. 34). 40).

  The main differences between treatment device 208 and treatment device 9008 relate to the differences between cartridge 2057 and cartridge 957 (FIGS. 35-40). In particular, (i) the cartridge 2057 has an actuator 2063 with two integral hinges instead of the curved lever 957, and (ii) the cartridge 2057 is opened instead of being substantially sealed, (Iii) The cartridge 2057 does not use a spring installed between the rear plug 2314 and the case 2059, and (iv) the cartridge 2057 has that of the cartridge 957 (flat portion 971 (FIG. 37)). ), And (v) the nozzle 2158 extends through the entire case 2059.

  Although the lever and case are shown as separate parts, this need not be the case. For example, in some embodiments, the lever and case can be formed as a single integral component.

  47A-47D illustrate another embodiment of a liquid storage and supply system that can be used in a cartridge. This embodiment includes a pump assembly 2650, a rigid vial 2652, a flexible bladder 2654, a piston 2656, a nozzle 2658, a slide 2660, a pump cover 2662, a nozzle cover 2750, a cavity 2780, and a rear plug 2814. And a valve 2834 (see FIG. 47D).

  Although cartridge 957 was a substantially sealed unit, it should be understood that the present invention is not limited to a cartridge in a substantially sealed unit. For example, some embodiments can use cartridges that are self-contained (or at least substantially self-contained), but that are not substantially sealed. In another embodiment, non-self-contained cartridges are also used.

  The second portion 941 of the housing 912 has a protrusion 953 that is adjusted to engage the first portion 939 and releasably lock the first portion 939 to the second portion 941. This does not mean that another type of engagement structure that locks the first part to the second part cannot be used.

  As described above, the cartridge can be used alone, that is, without using the rest of the device 908. Further, the cartridges and dispensers disclosed herein are not limited to ophthalmic treatments or even medical devices.

  FIG. 49 is a partially removed perspective view of an ophthalmic treatment apparatus 3008 according to another aspect of the present invention. The treatment device 3008 is similar to the treatment device 908 (FIGS. 34 to 40). Unless otherwise noted, reference numbers starting with “30” instead of the number “9” indicate similar elements, reference numbers starting with “31” instead of the number “10” indicate similar elements, and “11 Reference numbers beginning with “31” instead of “” are similar elements, reference numbers beginning with “33” instead of the number “12” indicate similar elements, and references beginning with “34” instead of “13” Numbers indicate similar elements. However, unless otherwise noted.

  For example, the treatment device 3008 includes a housing 3012, an eye cover 3016, a trigger 3018, and an eyelid press 3036, which are the housing 912, the eye cover 916, the trigger 918, and the eyelash hold 936 (see FIG. 34). 40). The housing 3012 has first and second portions 3039 and 3041, which are similar to the first and second portions 939 and 941.

  The treatment device 3008 further includes a case 3059, an actuator 3063, a pump assembly 3150, a rigid vial 3152, a flexible bladder 3154, a piston 3156, a nozzle 3158, a slide 3160, a pump cover 3162, and a cavity 3280. , Rear plug 3314, which are pump assembly 1050, rigid vial 1052, flexible bladder 1054, piston 1056, nozzle 1058, slide 1060, pump cover 1062, nozzle cover 1150, cavity 1180 described above with respect to FIGS. The same as the rear plug 1214.

  The main differences between the treatment device 3008 and the treatment device 908 are related to the difference between the cartridge 3057 and the cartridge 957 (FIGS. 35 to 40), the difference between the trigger 3018 and the trigger 918, and the difference between the numerical jig 3012 and the housing 912. is doing. In particular, (i) the actuator 3063 included in the cartridge 3057 is configured such that the actuator 3063 is pivotally supported by the lever 3079A instead of the lever 979 used by the actuator 963 (for example, at or using the elbow 3079C). Unlike the actuator 963 in that it has an arm 3079B, (ii) the cartridge 3057 has a spring 3404 (installed between the rear plug 3314 and the case 3059), which differs from the spring 1304 of the cartridge 957, Connected to, formed integrally with, and extending from actuator 3063. As described below, the spring 3404 provides a force to overcome friction and deliver a dose of medication from the cartridge 3057 to the eye. A trigger 3018 that is long and has a finger group 3028 has (i) a pedestal 3700 for lever 3079A, the pedestal 3700 has a surface shape that complements the surface of lever 3079A, and (ii) has an end 3430 ( Pivoted on housing 3012), which has a slot so that it can slide axially over pin 3432. Finally, unlike housing 912, housing 3012 does not have a pedestal for end 3430 of trigger 3018.

  50A to 50D are continuous side views showing the operation of the ophthalmologic treatment apparatus of FIG. 49 when a large force is gradually applied to the trigger. 50E through 50H show the operation of the ophthalmic treatment device of FIG. 49 after the trigger is fully activated and the trigger gradually returns to its original state.

  50A to 50D, when the trigger 3018 is compressed, the heel presser 3036 rotates, which moves the tissue near the eye to expose the conjunctival sac. The rotation of the collar holder 3036 is caused by the arm 3436, which opens the cover of the nozzle 3158. At the same time, trigger 3018 applies a radially inward force to lever 3079 of cartridge 3057. This pushes lever 3079A in the direction of housing 3059 (note that lever 3079A slides along pedestal 3700 in trigger 3018) and in response, elbow 3079C begins to straighten, As a result, the end of the arm 3079B moves toward the rear end of the cartridge and engages a portion of the annular thread 3401 of the vial 3152. In some embodiments, the spring 3404 is compressed by movement of the arm. As more radial inward force is applied, the elbow 3079C is further straightened and the arm 3079B continues to move backwards, driving the piston 3156 in the same direction to allow the pump to operate (as described in detail above). ), Compresses (or further compresses) the spring 3404.

  Next, looking at FIGS. 50E through 50H, a more radial force is applied to the lever 3079A, and the arm 3079B eventually disengages from a portion of the annular thread 3401, thereby causing the vial 3152 and the piston 3156 to move to the arm 3079B. The power applied from is lost. As a result, the restoring force or spring-like nature of the pump assembly 3150 and the spring force of the compressed spring 3404 causes the piston 3156 and vial 3132 to move toward the forward end of the cartridge 3057, thereby providing a predetermined amount. The medicine (other substances) is pushed out from the nozzle 3158.

  51 is a perspective view of the ophthalmic treatment device of FIG. 49, with the housing open.

  FIG. 52 is a partially exploded perspective view of the ophthalmic treatment apparatus of FIG.

  53 is a partially exploded side view of the ophthalmic treatment apparatus of FIG.

  The cartridge 3057 is depicted such that the treatment device has a number of features, such as a housing 3012, an eye cover 3016, a trigger 3018, a heel retainer 3036, etc., but the cartridge is only part of these features. It can also be used for therapeutic devices. For example, in some embodiments, the cartridge 3057 is used with a treatment device that does not have a cover to hide the cartridge. Thus, even when installed in the housing, the cartridge is always visible. In other embodiments, the cartridge is used, for example, in a treatment device that does not have an eye cover 3096, a trigger 3018, and a heel presser 3036. Of course, some treatment devices have more features than the treatment device 3008.

  Further, it is noted that although cartridge 3057 is depicted as being used in a housing, as described above for cartridge 957, cartridge 3057 can be used alone, that is, without a housing. Should. For example, the user can use the cartridge 3057 by himself and push the actuator 3063 with his / her hand. In addition, if desired, heel presses and other features can be incorporated into the cartridge 3057 to further assist the user in supplying the medication. The heel press used does not have to be a trigger type like the heel press 3036. In some embodiments, the heel presser can be integrally formed with the housing 3059 of the cartridge 3057. In another embodiment, it is possible to use a heel presser that is not integral with the cartridge 3057 but is formed separately and then attached to the cartridge.

  FIG. 54 and FIG. 55 show one method of attaching the eyelid presser to the cartridge. This method uses a cap 3500 that is provided with an integrated heel retainer 3502 and is adapted to be releasably secured to the cartridge 3057. In particular, the cap 3500 has a peripheral wall 3504 that is shaped and dimensioned to receive the end of the cartridge 3057. Perimeter wall 3504 defines an opening 3506 that is tuned to receive a protrusion 3077 that extends from housing 3059 of cartridge 3057. With this configuration, the cap 3500 is pressed or fitted to the cartridge 3057 and engages with the cartridge to releasably fix the cap 3500 to the cartridge 3057. The peripheral wall 3504 of the cap further defines an opening 3508 at a location coinciding with the nozzle 3158 so as not to impede the flow of drug delivered from the nozzle 3158.

  56 to 58 are views of a cartridge having another cap 3600 with an integrated heel press 3602. FIG. The cap 3600 is the same as the cap 3500 (FIGS. 54 and 55) except for the design of the heel presser 3602. Reference numbers beginning with “36” instead of the number “35” indicate similar elements. As can be seen from the figure, the distance from the nozzle to the eaves holder 3602 is shorter than in the previous embodiment. As those skilled in the art will appreciate from the teachings of this application, the shape, configuration, and orientation of the heel retainer are used to achieve comfort for the patient, etc. It can be adjusted as desired to facilitate the delivery of drops.

  Several other ways of providing a cartridge with a heel hold are shown in FIGS.

  Other methods of placing the heel presser releasably or fixedly on the cartridge should be apparent to those skilled in the art from the present description.

  FIG. 59 shows one embodiment of the nozzle, piston, and vial used in the cartridge of FIG. Unless otherwise noted, reference numbers beginning with “4” instead of the number “3” indicate similar elements. This particular embodiment shows two slots 4116 for passages through which liquids and other materials pass. The two slots 4116 are located diametrically opposite each other when viewed with respect to the central hole of the nozzle 4158. Such an arrangement of slots generally results in an elongate spray pattern (ie, the spray pattern of drug delivered from the device has a slightly elongated cross section).

  One advantage of this slot arrangement is that the elongated spray pattern is more compatible with the shape in the conjunctival sac when compared to the circular spray pattern. Therefore, such a slot arrangement results in a greater proportion of the drug reaching the conjunctival sac when compared to the rate of drug reaching the conjunctival sac when a circular jet pattern is used.

  As noted above, it is often desirable to direct the drug to a specific area of the eye. In at least some embodiments, it is desirable to deliver the drug into the conjunctival sac, often referred to as the conjunctival blind tube, which is generally elongated.

  When such a slot arrangement is used, the keying is preferably incorporated into the cartridge 3057 or treatment device 3008 so that the generally elongate spray pattern substantially matches the position of the shape within the generally elongate conjunctival sac. Although not shown in FIG. 66, the keying has a flat side wall that complements, coincides with, and contacts the flat side wall of cartridge case 3059 in vial 4052 or a portion thereof. Can be incorporated. For example, the flat side wall 1302 of the vial (FIGS. 39A, 39B) reduces the width of the vial 1052 so that the vial 1062 can fit into the inner cavity defined by the case 959.

  60A to 60D are views of other embodiments of nozzles, pistons, and vials used in the cartridge of FIG. Unless otherwise noted, reference numbers beginning with “5” instead of the number “3” indicate similar elements. This embodiment also uses two diametrically opposed slots 5116 to achieve a generally elongate spray pattern.

  Other configurations for providing a generally elongate reproduction pattern will be apparent to those skilled in the art from the present description.

  It should be understood that despite the advantages of a generally elongate spray pattern, the treatment device of FIG. 49 is not limited to such a spray pattern.

  Unless otherwise specified, for example, the phrase “extends radially (radially)” means “extends in a direction having, for example, a radiation component”. This direction can therefore be purely radial, or it can have a radial component in addition to the axial or circumferential component.

  Unless otherwise specified, for example, the phrase “connected” means “directly connected” or “indirectly connected”. Therefore, unless otherwise specified, “connected” means “directly connected” or “indirectly connected”.

  Further, unless otherwise specified, for example, “comprising”, “having”, “including” and all utilization forms thereof are considered to be unlimited without excluding other elements and features.

  It will be apparent to those skilled in the art from the teachings herein that various changes and modifications may be made to the foregoing and other embodiments of the invention without departing from the spirit of the invention as defined in the claims. be able to. For example, the components of the dispenser can be composed of a number of other materials that are currently known or will be known to perform the function of that component. Similarly, the components of the dispenser can take any of a wide variety of shapes and configurations. The dispenser can also be used to deliver a variety of fluids and other materials for various applications, such as, for example, eye, nose, dermatology, other pharmacological or OTC. Furthermore, the sterilization and filling device used to fill the dispenser of the present invention can be of various configurations now known or future known for dispenser filling. For example, any of a variety of mechanisms for sterilizing, feeding, discharging or filling the dispenser can be used. In addition, the dispenser can incorporate any of a variety of features for employing such a filling device or method. Furthermore, each of the pump and the supply valve can be configured differently from that disclosed in the present application. Accordingly, the detailed description of the presently preferred embodiments should be understood as an example and not in a limiting sense.

FIG. 4 is a partially removed perspective view of an ophthalmic treatment device incorporating a dispenser according to a preferred embodiment of the present invention. It is a figure similar to FIG. 1 without a dispenser. FIG. 2 is a perspective view of the ophthalmic treatment apparatus of FIG. 1. 1B is an exploded perspective view of the ophthalmic treatment device of FIG. 1B. FIG. 1B is an exploded side view of the ophthalmic treatment apparatus of FIG. 1B. FIG. FIG. 2 is a side view, including a partial cross-section, showing in more detail the dispenser of FIG. 1 with a pump assembly, a vial, a bladder, and the pump assembly in a closed position. FIG. 3 is a view similar to FIG. 2 with the dispenser rotated 90 ° in the orientation of FIG. 2 and the pump assembly in an extended state. 2 is a central cross-sectional view along the longitudinal axis of the piston of the pump assembly of FIG. FIG. 2 is a front view of a tip of a nozzle of the pump assembly of FIG. 1. FIG. 6 is a longitudinal sectional view taken along line 6-6 in FIG. FIG. 4 is a central cross-sectional view of the pump assembly of FIGS. 2 and 3 along the longitudinal axis of a slide or body that essentially forms a compression region. FIG. 4 is a central cross-sectional view along the longitudinal axis of the flexible pump cover of the pump assembly of FIGS. 2 and 3, with the pump cover extending from the tip of the nozzle to a rigid vial allowing reciprocating movement of a piston connected to the vial It shows how it is configured to Fig. 4 is a central cross-sectional view along the longitudinal axis of the rigid vial of the dispenser of Figs. FIG. 10 is an enlarged view of a portion of the vial of FIG. 9 showing a posterior attachment for receiving the sac of FIG. FIG. 4 is a central cross-sectional view along the longitudinal axis of the sac of the dispenser of FIGS. 2 and 3, in which a three-ribbed structure is installed so that the sac collapses into a predetermined collapsed state. Indicates that It is an enlarged view of a part of the sac of FIG. It is the figure which expanded a part of sac of FIG. It is sectional drawing along the horizontal axis of the sac of FIG. A separate capsular of the dispenser of FIGS. 2 and 3 having an elongated cut or elongated buffer in the outer wall of the sac installed within the rigid vial to facilitate collapse of the arc passing through each chord of the arc. It is a section schematic diagram showing an embodiment. FIG. 2 is a top view of a posterior stopper used to close the posterior end of the inner capsule by forming a sandwich-type structure between the rigid vial and the posterior stopper to seal the dispenser of FIGS. is there. FIG. 14 is a cross-sectional view of the rear plug taken along line 14-14 of FIG. It is the elements on larger scale of the back stopper of Drawing 14, and shows the annular side wall of a stopper in detail. FIG. 2 is a continuous side view, partly in section, showing the reduction of the liquid volume and the corresponding expansion of the bladder in the full, half, empty state of the dispenser of FIG. 1, respectively. FIG. 2 is a continuous side view, partly in section, showing the reduction of the liquid volume and the corresponding expansion of the bladder in the full, half, empty state of the dispenser of FIG. 1, respectively. FIG. 2 is a continuous side view, partly in section, showing the reduction of the liquid volume and the corresponding expansion of the bladder in the full, half, empty state of the dispenser of FIG. 1, respectively. FIG. 4 is a partial cross-sectional side view showing the steps of attaching the capsule to the vial during sterilization and filling of the dispenser of FIGS. FIG. 4 is a partial cross-sectional side view showing the steps of attaching the capsule to the vial during sterilization and filling of the dispenser of FIGS. FIG. 4 is a partial cross-sectional side view showing the steps of attaching the capsule to the vial during sterilization and filling of the dispenser of FIGS. FIG. 6 is a perspective view of another embodiment of the dispenser of the present invention. FIG. 18 is an end elevation view of the dispenser of FIG. 17. FIG. 19 is a cross-sectional view of the dispenser of FIGS. 17 and 18 taken along line 19-19 of FIG. FIG. 20 is a cross-sectional view of the dispenser of FIGS. 17 and 18 taken along line 20-20 of FIG. It is a perspective view of the back stopper of the dispenser of FIG. It is sectional drawing of the back stopper of FIG. It is sectional drawing of the back stopper of FIG. FIG. 22 is a partial cross-sectional view of the leg extending in the axial direction of the rear plug of FIG. 21 and projecting in the radial direction, and shows a state in which the flexible sac engages with the leg in a predetermined collapsed state. It is the leg of a back plug and a fragmentary sectional view of a sac, and shows the state where a sac is expanding. It is sectional drawing of the flexible sac of the dispenser of FIG. FIG. 27 is a partial enlarged cross-sectional view of a part of the flexible sac of FIG. 26. FIG. 18 is a front view of an integral nozzle and slide of the dispenser of FIG. 17. FIG. 29 is a cross-sectional view of the integrated nozzle and slide along line 29-29 of FIG. 28. FIG. 18 is a side view of an integral piston and rigid vial of the dispenser of FIG. FIG. 31 is a partial cross-sectional view of the integrated piston and rigid vial of FIG. 30. FIG. 18 is a cross-sectional view of a flexible nozzle cover and bellows of the dispenser of FIG. 17. To fill the dispenser with a drug or other substance, it has a resealable portion on the flexible sac from which to insert a needle or similar injection member, and the needle hole is created by applying thermal energy. FIG. 6 is a cross-sectional view of another embodiment of the dispenser of the present invention adapted to be sealed. 6 is a front top perspective view of an ophthalmic treatment apparatus according to another embodiment of the present invention. FIG. FIG. 34B is a side view of the ophthalmic treatment apparatus of FIG. 34A. FIG. 34B is a bottom view of the ophthalmic treatment apparatus of FIG. 34A. FIG. 34B is a perspective view of the ophthalmic treatment apparatus of FIG. 34A with the housing open. FIG. 34B is a side view of the ophthalmic treatment apparatus of FIG. 34A with the housing open. FIG. 35B is an enlarged view of a part of the cartridge of FIG. 35A. FIG. 35B is a partially exploded perspective view of the ophthalmic treatment apparatus of FIG. 35A. FIG. 35B is a side view, partly removed, of the cartridge of FIG. 35A. FIG. 39 is a rear view of the integrated piston and vial of FIG. 38. FIG. 39 is a rear bottom view of the integrated piston and vial of FIG. 38. FIG. 39 is a side view of the integrated piston and vial of FIG. 38. FIG. 39 is a cross-sectional view of a portion of the integrated piston and vial of FIG. 38. FIG. 34B is a side view of the ophthalmic treatment apparatus of FIG. FIG. 34B is a front bottom view of the ophthalmic treatment apparatus of FIG. 34A with a portion removed. FIG. 34B is a cross-sectional view of the ophthalmic treatment apparatus of FIG. 34A. FIG. 6 is a partial cross-sectional side view of another embodiment of a rigid vial and bladder with the vial filled and uncapped. FIG. 41B is a partial cross-sectional side view of the vial with the lid closed showing the rigid vial and sac of FIG. 41A. It is the front top view made into the partial virtual line of the ophthalmologic treatment apparatus by another embodiment of this invention. FIG. 42 is a partially exploded perspective view of the ophthalmic treatment apparatus of FIG. 41. 42 is a perspective view of the cartridge of FIG. 41. FIG. 42 is a perspective view of the cartridge of FIG. 41. FIG. 42 is a perspective view of the cartridge of FIG. 41. FIG. FIG. 42 is an exploded perspective view of the cartridge of FIG. 41. FIG. 42 is a cross-sectional view of the cartridge of FIG. 41 with a heel press according to one embodiment. It is a figure which shows another embodiment of a storage and supply system. It is a figure which shows another embodiment of a storage and supply system. It is a figure which shows another embodiment of a storage and supply system. It is a figure which shows another embodiment of a storage and supply system. FIG. 42 is a cross-sectional view of the cartridge of FIG. 41 with a heel press according to another embodiment. FIG. 6 is a perspective view of an ophthalmic treatment device according to another aspect of the present invention, partially removed. FIG. 50 is a partial cross-sectional, continuous side view showing the operation of the ophthalmic treatment device of FIG. 49 when a gradual force is applied to the trigger. FIG. 50 is a partial cross-sectional, continuous side view showing the operation of the ophthalmic treatment device of FIG. 49 when a gradual force is applied to the trigger. FIG. 50 is a partial cross-sectional, continuous side view showing the operation of the ophthalmic treatment device of FIG. 49 when a gradual force is applied to the trigger. FIG. 50 is a partial cross-sectional, continuous side view showing the operation of the ophthalmic treatment device of FIG. 49 when a gradual force is applied to the trigger. FIG. 50 is a partial cross-sectional, continuous side view showing the operation of the ophthalmic treatment device of FIG. 49 when it gradually returns to its initial state after the trigger is fully activated. FIG. 50 is a partial cross-sectional, continuous side view showing the operation of the ophthalmic treatment device of FIG. 49 when it gradually returns to its initial state after the trigger is fully activated. FIG. 50 is a partial cross-sectional, continuous side view showing the operation of the ophthalmic treatment device of FIG. 49 when it gradually returns to its initial state after the trigger is fully activated. FIG. 50 is a partial cross-sectional, continuous side view showing the operation of the ophthalmic treatment device of FIG. 49 when it gradually returns to its initial state after the trigger is fully activated. FIG. 50 is a perspective view of the ophthalmic treatment device of FIG. 49 with the housing open. FIG. 50 is a partially exploded perspective view of the ophthalmic treatment apparatus of FIG. 49. FIG. 50 is a partially exploded side view of the ophthalmic treatment apparatus of FIG. 49. FIG. 50 is an enlarged side view of the cartridge of FIG. 49 with a reed detachably installed according to another aspect of the present invention. FIG. 55 is a perspective view of the cartridge and the collar holder of FIG. 54. FIG. 50 is a side view of the cartridge of FIG. 49 with the heel presser of another embodiment detachably installed. FIG. 50 is a side view of the cartridge of FIG. 49 with the heel presser of another embodiment detachably installed. FIG. 57 is a perspective view of the cartridge and the collar holder of FIG. 56. FIG. 50 is a diagram of one embodiment of a nozzle, piston, vial that can be used with the cartridge of FIG. 49. FIG. 50 is an illustration of another embodiment of a nozzle, piston, vial that can be used with the cartridge of FIG. 49. FIG. 50 is an illustration of another embodiment of a nozzle, piston, vial that can be used with the cartridge of FIG. 49. FIG. 50 is an illustration of another embodiment of a nozzle, piston, vial that can be used with the cartridge of FIG. 49. FIG. 50 is an illustration of another embodiment of a nozzle, piston, vial that can be used with the cartridge of FIG. 49.

Claims (41)

An ophthalmic dispenser,
A body defining a fluid container;
A slide coupled in fluid communication with the container and defining an axially elongated passage; a pump having a piston slidably received within the axially elongated passage; and the slide being an elongated passage in the axial direction Defining a compression region therein, a first portion formed between the compression region and the container, and a second portion located opposite the compression region with respect to the first portion, And the compression region is defined by a second radius that is smaller than the first radius, and at least one of the piston and the slide is (i) the tip of the piston is the slide. A first operating position received in the first portion of the container, wherein the compression region is connected in fluid communication with the container and receives fluid therefrom; and (ii) the tip of the piston Movable with respect to the other between an acceptable carrier rest position within said second portion of said slide,
The nozzle extends around the valve seat, an annular, axially extending valve seat (valve seat), a discharge port connected in fluid communication between the valve seat and the compression region, A flexible valve cover (valve cover: valve cover) that forms an annular, rearwardly extending joint surface therebetween is provided, and the joint surface can be connected in fluid communication with the discharge port, and the valve cover At least a portion of: (i) a normally closed position where the valve cover engages the valve seat and forms a fluid tight seal therebetween; and (ii) at least a portion of the valve cover. In response to the flow of fluid from the outlet at a pressure greater than the pressure for opening the valve, and is movable between an open position for leaving the valve seat and passing the pressurized fluid therebetween. Yes,
At least one spring drivingly connected to at least one of the piston and the slide, the spring moving at least one of the piston and the slide from the first operating position to the rest position; An ophthalmic dispenser that is actuated to pressurize fluid in the compression region and then deliver a metered dose of fluid from the valve to a user's eye. The ophthalmic dispenser according to claim 1, further comprising:
An actuator is drivably connected to at least one of the piston and the slide, and moves at least one of the piston and the slide from the rest position to the first operating position. . The ophthalmic dispenser according to claim 1,
The ophthalmic dispenser wherein the pump defines an elongate axis and the actuator defines a path of motion across the elongate axis of the pump. An ophthalmic dispenser according to claim 2,
The actuator is drivingly connected to at least one of a trigger, the trigger, the piston, and a slide, and at least one of the piston and the slide is moved from the rest position in response to the movement of the trigger. An ophthalmic dispenser comprising: a lever arm that moves to the first operating position. An ophthalmic dispenser according to claim 4,
The ophthalmic dispenser characterized in that the spring is formed integrally with the lever arm. An ophthalmic dispenser according to claim 5,
The spring engages the main body, moves the main body, and then moves at least one of the piston and the slide from the first operating position to the rest position. An ophthalmic dispenser characterized in that it is defined by a portion. The ophthalmic dispenser according to claim 1,
At least one of the piston tip and the compression area of the slide is softer than the other, the piston tip and the compression area form an interference fit, thereby forming a fluid tight seal therebetween. Characteristic ophthalmic dispenser. The ophthalmic dispenser according to claim 1,
The ophthalmic dispenser characterized in that the volume of the compression region is approximately equal to the volume of the metered dose of fluid supplied from the valve. The ophthalmic dispenser according to claim 1,
In the rest position, the tip of the piston is located in the second part of the slide, and the outlet is connected in fluid communication with the container to reduce the pressure between the outlet and the compression region. And the valve is closed. The ophthalmic dispenser according to claim 1,
At least one of the piston and the slide includes: (i) the rest position in which the tip of the piston is located in the second portion of the slide; and (ii) the tip of the piston is the position of the slide. A first operating position located in a first portion, wherein the compression region is connected in fluid communication with the container and receives fluid therefrom; and (iii) the tip of the piston is in the compression region. A fluid tight seal is formed between the tip of the piston and the compression region, pressurizing the fluid in the compression region to a pressure greater than the pressure for opening the valve, A second actuating position that opens the valve and is supplied from the valve; and (iv) the tip of the piston is located in the second portion of the slide, and the outlet is in fluid communication with the container. Connected, said The pressure between the outlet and the compressed area is reduced, ophthalmic dispensers, characterized in that between said rest position closing the valve, is movable with respect to the other. The ophthalmic dispenser according to claim 1,
The nozzle defines a stop surface that contacts the tip of the piston in the rest position, the tip of the piston and the surface of the stop surface cooperate, and when the tip of the piston is in the rest position, An ophthalmic dispenser characterized in that the volume in the second part of the slide is substantially zero. The ophthalmic dispenser according to claim 1,
The ophthalmic dispenser wherein the stop surface defines a first configuration and the tip of the piston defines a second configuration substantially coincident with the first configuration. An ophthalmic dispenser according to claim 12,
The ophthalmic dispenser wherein the nozzle defines a single, angularly extending outlet. The ophthalmic dispenser according to claim 13, further comprising:
It includes a heel presser that engages with facial tissue near the eyes, moves the heel downward, and exposes the conjunctival sac when supplying a measured dose, and the nozzle outlet is aligned with the heel presser An ophthalmic dispenser for dispensing a metered dose into the exposed conjunctival sac. An ophthalmic dispenser for supplying liquid,
A housing;
A first actuator coupled to the housing;
A self-contained cartridge,
The cartridge is
A vial, and the vial includes an internal fluid receiving chamber therein;
A pump in fluid communication with the fluid receiving chamber for pumping liquid received therein from the dispenser;
A nozzle installed in fluid communication with the pump and passing the pumped liquid therethrough;
A case that holds the nozzle, the pump, and the vial in this order along a longitudinal axis in a direction toward the rear end of the dispenser, and the case receives the nozzle. Having a front wall with an opening for,
A second actuator connected to the case and responsive to the first actuator; the second actuator having at least a portion located outside the case; and at least a portion located inside the case. And is operably connected to at least one of the pump and the vial, and in the first stage of operation of the actuator, at least one of the pump and the vial is already along the longitudinal axis. Moving in one direction, and in the second stage of operation by the actuator, at least one of the pump and the vial moves away from the other,
An ophthalmic dispenser characterized by that. An ophthalmic dispenser according to claim 15,
The ophthalmic dispenser characterized in that the cartridge is integrally formed and has two main parts that are joined together to form a case. An ophthalmic dispenser according to claim 15,
The second actuator has a first end and a second end, the first end is pivotally supported by the case, and the second end is functionally connected to the pump. The actuator further comprises a pivot disposed between the first end and the second end. An ophthalmic dispenser according to claim 15,
The ophthalmic dispenser characterized in that the case further comprises a longitudinally extending portion having an inner surface substantially coincident with the longitudinally extending portion of the vial. An ophthalmic dispenser according to claim 15,
The vial, pump, and nozzle form part of a fluid storage and supply system, the fluid storage and supply system has an envelope that defines a shape, and the case includes the enclosure of the fluid storage and supply system. An ophthalmic dispenser comprising an outer container defining a shape substantially the same as the shape defined by the outer container. A method,
Providing a plurality of cartridges for storing and supplying ophthalmic solution; and the plurality of cartridges are substantially identical to each other, each having a vial, a pump, and a nozzle, the vial being defined therein An internal fluid receiving chamber, wherein the pump is in fluid communication with the fluid receiving chamber and pumps fluid received therein from the cartridge, and the nozzle is disposed in fluid communication with the pump to communicate with the pumped fluid. A case in which the cartridge is further passed, and the cartridge further holds the nozzle, the pump, and the vial in this order along the vertical axis in a direction toward the rear end of the cartridge; An actuator operably connected to the pump;
Mounting at least one of the plurality of cartridges in an ophthalmic dispenser having an actuator operably connected to the cartridge;
Supplying eye drops using at least one of the cartridges without installing the cartridge in an ophthalmic dispenser having an actuator operatively connected to the cartridge;
A method comprising the steps of: A method,
Providing a plurality of cartridges for storing and supplying ophthalmic solution; and wherein the plurality of cartridges are substantially identical to each other, each having a vial, a pump, a nozzle, the vial receiving an internal fluid defined therein Having a chamber, wherein the pump is in fluid communication with the fluid receiving chamber for pumping liquid received therein from the cartridge, and the nozzle is disposed in fluid communication with the pump for passing the pumped liquid therethrough. The cartridge further holds the nozzle, the pump, and the vial in this order along the longitudinal axis in a direction toward the rear end of the cartridge; and the pump and the functional With an actuator connected to
Providing a plurality of dispensers adapted to receive and actuate the cartridge;
Selling at least one of the cartridges together with at least one of the dispensers;
Selling at least one of the cartridges without a dispenser;
A method comprising the steps of: An ophthalmic dispenser for supplying fluid,
A self-contained replaceable cartridge and the cartridge
A rear portion including a vial, the vial having an internal fluid receiving chamber defined therein;
A pump in fluid communication with the fluid receiving chamber for pumping ophthalmic solution received therein from the dispenser;
A nozzle disposed in fluid communication with the pump and allowing the pumped liquid to pass therethrough;
A case that holds the nozzle, the pump, and the rear portion in this order along the longitudinal axis toward the rear end of the dispenser; and the pump is at least part of the rear portion. Operatively connected and moved along the longitudinal axis along with the movement of the at least part of the rear portion along the axis, the case having a front wall having an opening for receiving the nozzle Have
An actuator operably connected to the at least a portion of the rear portion, and in a first stage of operation, the actuator moves the at least a portion of the rear portion along the longitudinal axis of the case. Moving in the direction towards the rear end, thereby moving the pump in the same direction, and in the second stage of operation, the rear part moves along the longitudinal axis in the direction towards the front end of the case Thus, the ophthalmic dispenser is characterized in that the pump is moved in a direction toward the front end of the case. An ophthalmic dispenser according to claim 22,
The ophthalmic dispenser characterized in that the cartridge is integrally formed and has two main parts that are joined together to form the case. An ophthalmic dispenser according to claim 23,
The ophthalmic dispenser characterized in that the case further comprises a longitudinally extending portion having an inner surface substantially coincident with the longitudinally extending portion of the vial. An ophthalmic dispenser according to claim 22,
The vial, the pump and the nozzle form part of a fluid storage and supply system, the fluid storage and supply system has an envelope defining a shape, and the case is a part of the fluid storage and supply system. An ophthalmic dispenser comprising an outer container defining a shape substantially the same as the shape defined by the outer container. An ophthalmic dispenser for supplying liquid,
A cartridge and the cartridge
A vial, and the vial has an internal fluid receiving chamber defined therein;
A pump in fluid communication with the fluid receiving chamber for pumping ophthalmic solution received therein from the dispenser;
A nozzle that is placed in fluid communication with the pump and allows the pumped liquid to pass through the interior;
A spring portion disposed behind the internal fluid receiving chamber defined therein;
A case for holding the nozzle, the pump, and the vial in this order in a state of being arranged in a direction toward the rear end of the dispenser along the vertical axis, and the case is an opening for receiving the nozzle Having a front wall with
An actuator operably connected to the pump, wherein the actuator moves the pump along a longitudinal axis in a direction toward the rear end of the case in a first stage of operation, whereby the internal fluid A force is applied to the receiving chamber to compress the spring, and in a second stage of operation, the compressed spring applies a force to help move the pump toward the front end of the case. Ophthalmic dispenser. An ophthalmic dispenser for supplying liquid,
A self-contained replaceable cartridge and the cartridge
A vial, and the vial has an internal fluid receiving chamber defined therein;
A pump in fluid communication with the fluid receiving chamber for pumping ophthalmic solution received therein from the dispenser;
A nozzle disposed in fluid communication with the pump and allowing the pumped liquid to pass therethrough;
A case that holds the nozzle, the pump, and the vial in this order along the vertical axis toward the rear end of the dispenser, and the case has an opening for receiving the nozzle Having a front wall with
An actuator having a first end and a second end, wherein the first end is pivotally supported by the case, the second end is operatively connected to the pump, and the actuator is The ophthalmic dispenser further comprises a pivoting portion disposed between the first end and the second end. An ophthalmic dispenser according to claim 27,
The ophthalmic dispenser characterized in that the cartridge is integrally formed and has two main parts that are joined together to form the case. An ophthalmic dispenser according to claim 28,
The ophthalmic dispenser characterized in that the case further comprises a longitudinally extending portion having an inner surface substantially coincident with the longitudinally extending portion of the vial. An ophthalmic dispenser according to claim 27,
The vial, pump, and nozzle form part of a fluid storage and supply system, the fluid storage and supply system having an envelope that defines a shape, and the case is located outside the fluid storage and supply system. An ophthalmic dispenser comprising an outer container defining a shape substantially the same as the shape defined by the surrounding container. An ophthalmic dispenser,
A first means for forming a fluid container;
A pump connected in fluid communication with the vessel and having an axially elongated passage and a second means for pumping fluid in the axially elongated passage; and the pump is in the axially elongated passage Defining a compression region, a first portion formed between the compression region and the container, and a second portion located opposite the first portion of the compression region, And the compression region is defined by a second dimension that is smaller than the first dimension, and at least one of the second means and the axially elongated passage is ( i) a first actuation wherein the second means is received in the first portion of the axially elongated passage and the compression region is connected in fluid communication with the tank and receives fluid therefrom; A position, and (ii) the second means Between a rest position in which is received within said second portion of the elongate passage in the axial direction, it is movable with respect to the other,
An annular, axially extending valve seat, a discharge port connected in flow communication between the valve seat and the compression region, an annular, axially extending joint extending around the valve seat The nozzle having a valve with a flexible valve cover forming a surface and the joint surface can be connected in fluid communication with the outlet, and at least a portion of the valve cover is (i) the valve cover is A normally closed position that engages the valve seat, closes the joint surface and forms a fluid tight seal therebetween, and (ii) fluid is greater than the pressure for opening the valve from the outlet Responsive to flowing under pressure, moveable between an open position that allows at least a portion of the valve to leave the valve seat and allow pressurized fluid to flow therebetween,
Diverting at least one of the second means and the axially elongated passageway from the first operating position to the rest position, and then pressurizing fluid in the compression region to force fluid from the valve A third means of supplying to the user's eyes;
An ophthalmic dispenser characterized by comprising: The ophthalmic dispenser of claim 31, further comprising:
An ophthalmic dispenser comprising: fourth means for actuating the pump and then moving at least one of the second means and the axially elongated passage relative to the other. An ophthalmic dispenser according to claim 32,
The ophthalmic dispenser wherein the pump defines an elongate axis and the fourth means defines a path of movement across the elongate axis of the pump. An ophthalmic dispenser according to claim 31,
The fourth means comprises a trigger, and a lever arm drivingly connected to at least one of the first means and the pump, the lever arm being elongated in the axial direction with the second means. An ophthalmic dispenser engagable by the trigger to move at least one of the passages with respect to the other. An ophthalmic dispenser according to claim 34,
The lever arm includes (1) a flexible curved main body that moves flexibly in a radial direction and an axial direction along with the movement of the trigger, and (2) a first arm portion, a second arm portion, and the first arm portion. And a second arm part flexibly connected to each other, and together with the movement of the trigger, the first and second arm parts can be moved in a radial direction and an axial direction. An ophthalmic dispenser characterized by defining at least one. The ophthalmic dispenser of claim 31, further comprising:
An ophthalmic dispenser comprising an actuator operatively connected to at least one of the first means and the pump and defining the third means. An ophthalmic dispenser according to claim 36,
The third means engages the first means, moves the first means, and then moves at least one of the axially elongated passages relative to the second means with respect to the other. An ophthalmic dispenser defined by a flexure curve of the actuator. The ophthalmic dispenser of claim 31, further comprising:
At least one of: a wrinkle presser capable of engaging with facial tissue near the eye, moving the tissue, and then moving a nearby wrinkle downward; the wrinkle presser; and the first means and the pump An ophthalmic dispenser comprising: an actuator that is connected to both of the driving members and that operates the heel presser and the pump substantially simultaneously. An ophthalmic dispenser according to claim 38,
3. The ophthalmic dispenser according to claim 3, wherein the third means is formed by the actuator. A method of filling an ophthalmic dispenser comprising:
The ophthalmic dispenser includes a rigid housing defining a first fluid receiving chamber, and a second fluid that is axially spaced with respect to the first fluid receiving chamber and is coupled in fluid communication therewith. A flange defining a receiving chamber, an axially extending body portion received in the first fluid receiving chamber of the housing, a first annular sealing surface, and the axial direction of the first annular sealing surface A flexible bladder, which is axially spaced on the opposite side with respect to the body portion extending to and defining a second annular sealing surface received within the flange of the housing, in fluid communication with the first fluid receiving chamber Connected to the pump, an annular, axially extending valve seat, a discharge port connected in fluid communication between the valve seat and the pump, and extending near the valve seat And a nozzle having a flexible valve cover forming an annular, axially extending joint surface therebetween, the joint surface being fluidly connectable to the outlet and at least one of the valve covers. The part is (i) the normally closed position where the valve cover engages the valve seat, closes the joint surface and forms a fluid tight seal therebetween, and (ii) the fluid opens the valve Responsive to flowing through the outlet at a pressure greater than that for pressure, and moving between open positions to allow at least a portion of the valve cover to move away from the valve seat and allow pressurized fluid to pass between them And at least one spring drivingly connected to at least one of the pump and housing, and the spring moves at least one of the pump and housing relative to the other to operate the pump. The method,
(I) introducing eye drops into the first fluid receiving chamber of the housing;
(Ii) at least partially inserting the axially elongated body portion of the flexible bladder into the first fluid receiving chamber of the housing, wherein the first fluid receiving chamber is filled with eye drops; Allowing the second fluid receiving chamber to be at least partially filled with eye drops;
(Iii) forming a first substantially fluid tight seal between the first annular sealing surface of the bladder and the housing, the second annular sealing surface of the bladder and the housing of the housing; Forming a second substantially fluid tight seal between the flanges, the first fluid receiving chamber being filled with eye drops substantially free of gas, the second fluid receiving chamber; Allowing the ophthalmic solution to be at least partially filled;
A method comprising the steps of: 41. The method of claim 40, further comprising:
Crushing the flexible bladder and then inserting the bladder into the first fluid receiving chamber of the housing.

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