JP2006510669A - 眼障害および眼疾患の処置のためのスーパーオキシドジスムターゼ模倣物 - Google Patents
眼障害および眼疾患の処置のためのスーパーオキシドジスムターゼ模倣物 Download PDFInfo
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- YTZALCGQUPRCGW-ZSFNYQMMSA-N verteporfin Chemical compound N1C(C=C2C(=C(CCC(O)=O)C(C=C3C(CCC(=O)OC)=C(C)C(N3)=C3)=N2)C)=C(C=C)C(C)=C1C=C1C2=CC=C(C(=O)OC)[C@@H](C(=O)OC)[C@@]2(C)C3=N1 YTZALCGQUPRCGW-ZSFNYQMMSA-N 0.000 description 1
- 208000029257 vision disease Diseases 0.000 description 1
- 230000009978 visual deterioration Effects 0.000 description 1
- 230000004393 visual impairment Effects 0.000 description 1
- 229940061392 visudyne Drugs 0.000 description 1
- 239000002699 waste material Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/409—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil having four such rings, e.g. porphine derivatives, bilirubin, biliverdine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4178—1,3-Diazoles not condensed 1,3-diazoles and containing further heterocyclic rings, e.g. pilocarpine, nitrofurantoin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/555—Heterocyclic compounds containing heavy metals, e.g. hemin, hematin, melarsoprol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
Landscapes
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Diabetes (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Gastroenterology & Hepatology (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Ophthalmology & Optometry (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Dermatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US43140102P | 2002-12-06 | 2002-12-06 | |
| PCT/US2003/038678 WO2004052227A2 (en) | 2002-12-06 | 2003-12-05 | Superoxide dismutase mimics for the treatment of ocular disorders and diseases |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2006510669A true JP2006510669A (ja) | 2006-03-30 |
| JP2006510669A5 JP2006510669A5 (enExample) | 2006-08-24 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2004559315A Pending JP2006510669A (ja) | 2002-12-06 | 2003-12-05 | 眼障害および眼疾患の処置のためのスーパーオキシドジスムターゼ模倣物 |
Country Status (9)
| Country | Link |
|---|---|
| US (2) | US20060089343A1 (enExample) |
| EP (1) | EP1581212A4 (enExample) |
| JP (1) | JP2006510669A (enExample) |
| CN (1) | CN1717234A (enExample) |
| AU (1) | AU2003298917A1 (enExample) |
| BR (1) | BR0317026A (enExample) |
| CA (1) | CA2505608A1 (enExample) |
| MX (1) | MXPA05005240A (enExample) |
| WO (1) | WO2004052227A2 (enExample) |
Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2014514328A (ja) * | 2011-04-26 | 2014-06-19 | レトロトップ、 インコーポレイテッド | 酸化的網膜疾患 |
| US10052299B2 (en) | 2009-10-30 | 2018-08-21 | Retrotope, Inc. | Alleviating oxidative stress disorders with PUFA derivatives |
| US10058612B2 (en) | 2011-04-26 | 2018-08-28 | Retrotope, Inc. | Impaired energy processing disorders and mitochondrial deficiency |
| US10154978B2 (en) | 2011-04-26 | 2018-12-18 | Retrotope, Inc. | Disorders implicating PUFA oxidation |
| US10154983B2 (en) | 2011-04-26 | 2018-12-18 | Retrotope, Inc. | Neurodegenerative disorders and muscle diseases implicating PUFAs |
| US11447441B2 (en) | 2015-11-23 | 2022-09-20 | Retrotope, Inc. | Site-specific isotopic labeling of 1,4-diene systems |
| US11779910B2 (en) | 2020-02-21 | 2023-10-10 | Biojiva Llc | Processes for isotopic modification of polyunsaturated fatty acids and derivatives thereof |
| US12109194B2 (en) | 2021-02-05 | 2024-10-08 | Biojiva Llc | Synergistic combination therapy for treating ALS |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB2397067B (en) * | 2002-12-23 | 2005-05-11 | Destiny Pharma Ltd | Porphin & azaporphin derivatives with at least one cationic-nitrogen-containing meso-substituent for use in photodynamic therapy & in vitro sterilisation |
| GB2415372A (en) | 2004-06-23 | 2005-12-28 | Destiny Pharma Ltd | Non photodynamical or sonodynamical antimicrobial use of porphyrins and azaporphyrins containing at least one cationic-nitrogen-containing substituent |
| WO2006033734A2 (en) * | 2004-08-18 | 2006-03-30 | Sirion Therapeutics, Inc. | Combination compositions comprising 13-cis-retinyl derivatives and uses thereof to treat opthalmic disorders |
| WO2006091796A2 (en) * | 2005-02-22 | 2006-08-31 | Acucela, Inc. | Compositions and methods for diagnosing and treating retinal diseases |
| MX2009011360A (es) | 2007-04-20 | 2010-02-12 | Acucela Inc | Compuestos derivados de estirenilo para tratar enfermedades y trastornos oftalmicos. |
| CA2690229C (en) | 2007-06-29 | 2013-10-29 | Acucela, Inc. | Alkynyl phenyl derivative compounds for treating ophthalmic diseases and disorders |
| WO2009045479A1 (en) | 2007-10-05 | 2009-04-09 | Acucela Inc. | Alkoxy compounds for disease treatment |
| JP5559701B2 (ja) * | 2008-01-30 | 2014-07-23 | エージェンシー フォー サイエンス，テクノロジー アンド リサーチ | イミダゾリウム及びイミダゾリニウム化合物で線維症及び癌を治療する方法 |
| WO2009123569A1 (en) * | 2008-03-31 | 2009-10-08 | Agency For Science, Technology And Research | Method for treating neurological disorders with imidazolium and imidazolinium compounds |
| US8598150B1 (en) | 2008-04-02 | 2013-12-03 | Jonathan R. Brestoff | Composition and method for affecting obesity and related conditions |
| US8987245B2 (en) | 2008-04-02 | 2015-03-24 | Jonathan R. Brestoff Parker | Composition and method for affecting obesity and related conditions |
| EP2433640B1 (en) | 2010-09-24 | 2020-01-15 | OmniVision GmbH | Composition comprising SOD, lutein and zeaxanthin |
| WO2013109991A1 (en) | 2012-01-20 | 2013-07-25 | Acucela Inc. | Substituted heterocyclic compounds for disease treatment |
| EP2911662A4 (en) * | 2012-10-25 | 2016-09-28 | Technion Res & Dev Foundation | METHOD OF TREATING A DISEASE |
| BR112015022041A2 (pt) | 2013-03-12 | 2017-07-18 | Acucela Inc | derivados substituídos de 3-fenilpropilamina para o tratamento de doenças e distúrbios oftálmicas |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
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| JP2001521939A (ja) * | 1997-11-03 | 2001-11-13 | デューク・ユニバーシティー | 置換されたポルフィリン類 |
| JP2002535332A (ja) * | 1999-01-25 | 2002-10-22 | ナショナル・ジュウィッシュ・メディカル・アンド・リサーチ・センター | 置換ポルフィリン |
| JP2005508864A (ja) * | 2001-06-01 | 2005-04-07 | ナショナル・ジュウィッシュ・メディカル・アンド・リサーチ・センター | 糖尿病の治療、または移植術における使用、または免疫寛容の誘導のためのオキシダントスカベンジャー |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5252720A (en) * | 1989-03-06 | 1993-10-12 | Board Of Regents, The University Of Texas System | Metal complexes of water soluble texaphyrins |
| TW325997B (en) * | 1993-02-02 | 1998-02-01 | Senju Pharma Co | Pharmaceutical composition for preventing and treating retinal diseases |
| US6127356A (en) * | 1993-10-15 | 2000-10-03 | Duke University | Oxidant scavengers |
| US5994339A (en) * | 1993-10-15 | 1999-11-30 | University Of Alabama At Birmingham Research Foundation | Oxidant scavengers |
| US5798349A (en) * | 1994-03-14 | 1998-08-25 | The General Hospital Corporation | Use of green porphyrins to treat neovasculature in the eye |
| US6214817B1 (en) * | 1997-06-20 | 2001-04-10 | Monsanto Company | Substituted pyridino pentaazamacrocyle complexes having superoxide dismutase activity |
| US6180620B1 (en) * | 1997-06-20 | 2001-01-30 | G.D. Searle & Co. | Analgesic methods using synthetic catalysts for the dismutation of superoxide radicals |
| GB9817845D0 (en) * | 1998-08-17 | 1998-10-14 | Glaxo Group Ltd | Chemical compounds |
-
2003
- 2003-12-05 CN CNA2003801041193A patent/CN1717234A/zh active Pending
- 2003-12-05 AU AU2003298917A patent/AU2003298917A1/en not_active Abandoned
- 2003-12-05 WO PCT/US2003/038678 patent/WO2004052227A2/en not_active Ceased
- 2003-12-05 US US10/534,791 patent/US20060089343A1/en not_active Abandoned
- 2003-12-05 EP EP03796677A patent/EP1581212A4/en not_active Withdrawn
- 2003-12-05 JP JP2004559315A patent/JP2006510669A/ja active Pending
- 2003-12-05 MX MXPA05005240A patent/MXPA05005240A/es unknown
- 2003-12-05 CA CA002505608A patent/CA2505608A1/en not_active Abandoned
- 2003-12-05 US US10/729,213 patent/US20040116403A1/en not_active Abandoned
- 2003-12-05 BR BR0317026-8A patent/BR0317026A/pt unknown
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2001521939A (ja) * | 1997-11-03 | 2001-11-13 | デューク・ユニバーシティー | 置換されたポルフィリン類 |
| JP2002535332A (ja) * | 1999-01-25 | 2002-10-22 | ナショナル・ジュウィッシュ・メディカル・アンド・リサーチ・センター | 置換ポルフィリン |
| JP2005508864A (ja) * | 2001-06-01 | 2005-04-07 | ナショナル・ジュウィッシュ・メディカル・アンド・リサーチ・センター | 糖尿病の治療、または移植術における使用、または免疫寛容の誘導のためのオキシダントスカベンジャー |
Cited By (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| USRE49238E1 (en) | 2009-10-30 | 2022-10-11 | Retrotope, Inc. | Alleviating oxidative stress disorders with PUFA derivatives |
| US11510888B2 (en) | 2009-10-30 | 2022-11-29 | Retrotope, Inc. | Alleviating oxidative stress disorders with PUFA derivatives |
| US10052299B2 (en) | 2009-10-30 | 2018-08-21 | Retrotope, Inc. | Alleviating oxidative stress disorders with PUFA derivatives |
| US10058522B2 (en) | 2011-04-26 | 2018-08-28 | Retrotope, Inc. | Oxidative retinal diseases |
| JP2017125046A (ja) * | 2011-04-26 | 2017-07-20 | レトロトップ、 インコーポレイテッドＲｅｔｒｏｔｏｐｅ， Ｉｎｃ． | 酸化的網膜疾患 |
| US10154978B2 (en) | 2011-04-26 | 2018-12-18 | Retrotope, Inc. | Disorders implicating PUFA oxidation |
| US10154983B2 (en) | 2011-04-26 | 2018-12-18 | Retrotope, Inc. | Neurodegenerative disorders and muscle diseases implicating PUFAs |
| US11241409B2 (en) | 2011-04-26 | 2022-02-08 | Retrotope, Inc. | Neurodegenerative disorders and muscle diseases implicating PUFAs |
| US11285125B2 (en) | 2011-04-26 | 2022-03-29 | Retrotope, Inc. | Oxidative retinal diseases |
| US12156860B2 (en) | 2011-04-26 | 2024-12-03 | Biojiva Llc | Disorders implicating PUFA oxidation |
| JP2014514328A (ja) * | 2011-04-26 | 2014-06-19 | レトロトップ、 インコーポレイテッド | 酸化的網膜疾患 |
| US10058612B2 (en) | 2011-04-26 | 2018-08-28 | Retrotope, Inc. | Impaired energy processing disorders and mitochondrial deficiency |
| US11453637B2 (en) | 2015-11-23 | 2022-09-27 | Retrotope, Inc. | Site-specific isotopic labeling of 1,4-diene systems |
| US12060324B2 (en) | 2015-11-23 | 2024-08-13 | Biojiva Llc | Site-specific isotopic labeling of 1,4-diene systems |
| US11447441B2 (en) | 2015-11-23 | 2022-09-20 | Retrotope, Inc. | Site-specific isotopic labeling of 1,4-diene systems |
| US11779910B2 (en) | 2020-02-21 | 2023-10-10 | Biojiva Llc | Processes for isotopic modification of polyunsaturated fatty acids and derivatives thereof |
| US12109194B2 (en) | 2021-02-05 | 2024-10-08 | Biojiva Llc | Synergistic combination therapy for treating ALS |
Also Published As
| Publication number | Publication date |
|---|---|
| CN1717234A (zh) | 2006-01-04 |
| BR0317026A (pt) | 2005-10-25 |
| EP1581212A4 (en) | 2008-11-05 |
| CA2505608A1 (en) | 2004-06-24 |
| US20060089343A1 (en) | 2006-04-27 |
| US20040116403A1 (en) | 2004-06-17 |
| WO2004052227A2 (en) | 2004-06-24 |
| AU2003298917A1 (en) | 2004-06-30 |
| WO2004052227A3 (en) | 2005-03-31 |
| MXPA05005240A (es) | 2005-07-25 |
| EP1581212A2 (en) | 2005-10-05 |
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