JP2006341115A - Biological light measuring device - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To provide a biological light measuring device which does not have to fix a measuring section and has low restriction. <P>SOLUTION: In a biologic light measuring device which irradiates a subject with the light of two or more wavelengths guided from a light source by an optical fiber, has a measuring probe which condenses the light which passes through the subject from two or more sections, and generates the biologic passage light intensity image of the subject from the condensed passage light; the measuring probe has a cylindrical probe case which holds the optical fiber, an optical fiber fixing member which fixes the probe case at given intervals, and a supporting member which supports the optical fiber fixing member. In the cylindrical probe case, a locking lug which allows the engagement between the cylindrical probe case and the optical fiber fixing member is prepared. <P>COPYRIGHT: (C)2007,JPO&INPIT

Description

  The present invention relates to a biological light measurement device, and more particularly to a measurement probe of a biological light measurement device that is effective when applied to a newborn and an intraoperative subject.

  Conventionally, an apparatus for measuring the inside of a living body simply and without causing harm to the living body has been eagerly desired in the fields of clinical medicine and brain science. In response to this demand, an apparatus for measuring the inside of a living body by irradiating the living body with light having a wavelength from visible to infrared and detecting the light passing through the living body is disclosed in, for example, Japanese Patent Laid-Open No. 9-98972 (hereinafter referred to as “ Reference 1 ”) or JP-A-9-149903 (hereinafter referred to as“ Reference 2 ”).

  The "biological light measuring device" described in these documents is a modulated semiconductor laser that generates light with different modulation frequencies, an optical fiber for irradiation that directs the generated light to the living body and irradiates it at different positions, and a living body that passes through the living body. A detection optical fiber that collects the collected light and guides it to the photodiode, a measurement probe that fixes the tip of the irradiation and detection optical fiber to a predetermined position on the living body, and a living body light intensity output from the photodiode. A lock-in amplifier that separates the reflected light intensity corresponding to the wavelength and the irradiation position from the electrical signal to be expressed (hereinafter referred to as “biological passage light intensity signal”), and an A / D that converts the output of the lock-in amplifier into a digital signal The relative change amount of the oxidized and reduced hemoglobin concentration at each measurement point is calculated from the converter and the biological passage light intensity signal after A / D conversion. Image is composed of a display device for displaying a (topographic image).

  The conventional measurement probe is composed of an optical fiber fixing member that alternately arranges the tips of the irradiation optical fiber and the detection optical fiber in a lattice pattern, and a fixing belt that fixes the optical fiber fixing member to a living body. In this optical fiber fixing member, for example, a base of a plastic sheet having a thickness of about 3 mm is formed in a helmet or cap shape. A belt is attached to the optical fiber fixing member, and the optical fiber fixing member is fixed to a living body.

  In the optical fiber fixing member, a hole is formed at each of a plurality of positions where the living body is irradiated and detected with light, and an optical fiber folder is disposed in the hole. This optical fiber folder is composed of a hollow holder main body, a nut screw, and an optical fiber fixing screw, and the holder main body is fixedly attached to the optical fiber fixing member by the nut screw. An irradiation optical fiber or a detection optical fiber was inserted into the holder body, and the optical fiber was lightly brought into contact with the surface of the living body and fixed with an optical fiber fixing screw.

  As a result of studying the prior art, the present inventors have found the following problems.

  Along with recent advances in medical technology, early detection has made it possible to treat a considerable part, and in particular, there is a strong demand for an inspection device that is optimal for early detection of brain damage in newborns or monitoring of cerebral thrombosis during cardiac surgery. Yes.

  For example, in the case of a neonatal language disorder caused by a brain disorder, the part related to the language function of the neonate is established at an early stage, so if the brain disorder is discovered before this establishment and appropriate treatment is not given, it will last a lifetime. It was known that the newborn could no longer speak the language. For this reason, an inspection apparatus capable of early detection of brain damage in newborns has been desired.

  In addition, in the case of a newborn born with a visual impairment, it is impossible for the newborn to be aware of the visual impairment, and it is common for parents to find the visual impairment. However, it often takes about one year after the parents notice the newborn's visual impairment, which is problematic from the viewpoint of early detection and early treatment.

  As an inspection apparatus that solves this problem, attention has been focused on a biological light measurement apparatus that does not require fixation of a measurement part during measurement, has low restraint, and can perform measurement in an arbitrary place and environment.

  However, conventional biological light measurement devices have been developed on the premise that they are used in a sitting position or standing position. For living bodies that are difficult to hold a sitting position or standing position, such as a newborn baby, it is used for irradiation when the head moves. In addition, the contact position between the detection optical fiber and the scalp is shifted, and there is a problem that accurate measurement cannot be performed.

  Similarly, in the monitoring of a cerebral thrombus that causes clots generated during cardiac surgery to be transported to the brain and clog the blood vessels in the brain, the body position of the living body is in the recumbent position. There is a problem that the contact position is shifted and measurement cannot be performed.

  Furthermore, for a living body with relatively thin hair such as a newborn baby, it was relatively easy to avoid the hair and contact the irradiation and detection optical fibers with the scalp. There is a problem that it is difficult to avoid hair in the case of an adult who has many hairs and each hair is hard.

  An object of the present invention is to provide a living body light measurement device capable of performing living body light measurement in the lying position.

  Another object of the present invention is to provide a living body light measurement device capable of easily avoiding hair when a measurement probe is attached.

  Another object of the present invention is to provide a biological light measurement device capable of performing biological light measurement while applying a predetermined stimulus to a subject.

  Another object of the present invention is to provide a living body light measuring apparatus capable of improving diagnostic efficiency in living body light measurement.

  The above and other objects and novel features of the present invention will be apparent from the description of this specification and the accompanying drawings.

Of the inventions disclosed in the present application, the outline of typical features will be briefly described as follows.
(1) A measurement probe that irradiates a subject with light having a plurality of wavelengths guided by an optical fiber from a light source, and collects light that has passed through the subject from a plurality of parts, and the subject from the collected passing light In the biological light measurement device for generating a biological passage light intensity image of a specimen, the measurement probe includes an optical fiber fixing member that fixes the optical fiber at a predetermined interval, and a support member that supports and swings the optical fiber fixing member. Equipped with.
(2) In the biological optical measurement device according to (1) described above, the optical fiber fixing member is provided with a mounting hole for the optical fiber, and a hole extending continuously in the outer peripheral direction from the mounting hole. Prepared.
(3) In the biological optical measurement device according to (1) described above, a sensory stimulation unit including an acoustic unit that outputs a predetermined sound wave and / or a video unit that displays a predetermined image, and the sensory stimulation unit Image generating means for outputting a stimulus output and generating a living body light intensity image of the subject.
(4) The biological light measurement device according to (1) described above includes a display device, and displays the biological transmitted light intensity image on the display device.
(5) In the biological light measurement device according to (1) described above, the support member includes means for hanging and supporting the optical fiber fixing portion.
(6) In the living body optical measurement device according to (1) described above, the support member includes means for changing a suspended height of the optical fiber fixing portion.

  According to the means (1) to (6) described above, the measurement probe is divided into an optical fiber fixing member that fixes the optical fiber at a predetermined interval and a support member that supports the optical fiber fixing member so as to be swingable. By adjusting the mounting position and height of the optical fiber fixing member to the support member, the distance between the optical fibers, that is, the tip of the optical fiber, even when the subject is in the lying position Biological light measurement can be performed without moving the contact position between the portion and the epidermis of the subject. At this time, since the optical fiber fixing member is supported so as to be swingable with respect to the support member, accurate biological light measurement can be performed even for a newborn who is constantly moving as compared with an adult or the like. .

  At this time, by forming a hole in the optical fiber fixing member that is formed continuously to the optical fiber mounting hole and extends radially outward of the mounting hole, the optical fiber is attached to the optical fiber fixing member in the outer circumferential direction. Direct access to the subject's hair from the extending hole, that is, the subject's hair can be easily moved from the hole extending in the outer circumferential direction, so that the tip of the optical fiber and the scalp can be easily Can be contacted directly. That is, it is possible to improve the work efficiency of contact of the optical fiber with the subject. Therefore, it is possible to improve the diagnostic efficiency in the biological light measurement device.

  On the other hand, a sensory stimulation means including an acoustic means for outputting a predetermined sound wave or an image means for displaying a predetermined image, and an in-vivo light intensity image of a subject synchronized or not synchronized with an output from the acoustic means or the image means. By providing the image generating means for generating the sensory sensor, it is possible to give a predetermined sensory stimulus without directly attaching the sensory stimulus means to the newborn, and to accurately measure the biological light from the point of time when the stimulus is given Therefore, biological light measurement can be performed with high accuracy while giving a predetermined stimulus to the subject.

  Hereinafter, the present invention will be described in detail with reference to the drawings together with embodiments (examples) of the invention.

  Note that components having the same function are denoted by the same reference symbols throughout the drawings for describing the embodiment of the invention, and the repetitive description thereof is omitted.

(Embodiment 1)
FIG. 1 is a diagram for explaining a schematic configuration of the biological light measurement apparatus according to the first embodiment of the present invention. 101 is a measurement probe, 102 is a modulation semiconductor laser, 103 is a photodiode, 104 is a lock-in amplifier, 105 Denotes an A / D converter, 106 denotes an information processing device, 107 denotes an irradiation optical fiber, and 108 denotes a detection optical fiber. However, other means and mechanisms other than the measurement probe 101 use known means and mechanisms. In the first embodiment, the living body optical measurement that images the inside of the cerebrum by irradiating and detecting light from the skin of the head of the newborn while holding the position of the newborn being the subject in the recumbent position. The apparatus is shown when the number of measurement points is 24, with an intermediate point between irradiation and detection (reception) as a measurement point.

  In FIG. 2, the measurement probe 101 according to the first embodiment is based on, for example, a plastic sheet having a thickness of about 2 mm. The base is formed in a concave shape, and the optical fibers 107 and 108 are fixed so that the distal end portions of the irradiation and detection optical fibers 107 and 108 in contact with the subject are arranged at predetermined positions on the concave surface side. Thus, a shell plate 201 which is an optical fiber fixing member for fixing the irradiation and detection optical fibers along the head shape of the subject is configured. At both ends of the shell plate 201, one end of the belt is disposed, and by supporting the other end of the belt, the shell plate 201 is swung back and forth, right and left, that is, in the direction of the body axis of the subject and the direction perpendicular to the body axis. It is the structure which supports so that it can move. As a method of supporting the other end of the belt, two struts are provided at a predetermined interval, and the other end of the belt is supported by this strut, whereby the shell plate 201 is used for measuring, for example, a newborn in a lying position. In addition to supporting the head at the time of the measurement, the contact position between the optical fiber and the scalp due to the movement of the head during measurement is prevented. That is, by supporting the convex surface side, which is the back surface side of the shell plate 201 to which the irradiation and detection optical fibers 107 and 108 are attached, so as not to come into direct contact with a bed or the like that supports the subject in a lying position, The contact positions of the irradiation and detection optical fibers 107 and 108 and the scalp are prevented from shifting.

  In the measurement probe 101 of the first embodiment, the shell plate 201 is provided with a probe folder 211 for alternately arranging eight irradiation optical fibers 107 and eight detection optical fibers 108 in a square lattice pattern. ing. The detailed configuration of the measurement probe 101 will be described later.

  In addition, shell plates 201 having a plurality of sizes and radii of curvature are prepared in advance, and the examiner selects appropriately according to the size of the head of the newborn to be measured. It is possible to perform biological light measurement suitable for the size of the head of a newborn with a large difference.

  Next, based on FIG. 1, the structure and operation | movement of the biological light measuring device of this Embodiment 1 are demonstrated.

  The modulation semiconductor laser 102 includes, for example, eight optical modules each including two semiconductor lasers that respectively emit light having two wavelengths of 780 nm and 830 nm. Each optical module includes a driving circuit that drives each semiconductor laser, an oscillator that applies modulation signals having different frequencies to the driving circuit and modulates light emitted from each semiconductor laser, and each semiconductor laser. And an optical fiber coupler for introducing radiated light having a wavelength of 780 nm and 830 nm into one optical fiber (irradiation optical fiber 107).

  Accordingly, the mixed light of the two-wavelength light emitted from the modulated semiconductor laser 102 is irradiated to the head of a newborn, which is not shown, from the tip of the eight irradiation optical fibers 107 connected to each optical module. Is done. At this time, each irradiation optical fiber 107 is fixed to a probe holder arranged on the shell plate of the measurement probe 101, and irradiates light to different positions of the subject.

  The light that has passed through the head, that is, the light passing through the living body, is collected by the eight detection optical fibers 108 fixed to the probe holder disposed on the shell plate and guided to the photodiode 103. The light guided to the photodiode 103 is converted into a biological light intensity signal that is an electrical signal representing the biological light intensity by the photodiode corresponding to each of the eight detection optical fibers 108, and is output to the lock-in amplifier 104. Is done. The means for converting the light guided by the eight detection optical fibers 108 into an electric signal is not limited to a photodiode, and any other photoelectric conversion element such as a photomultiplier tube may be used. Good.

  The biological light intensity signal input to the lock-in amplifier 104 is separated into biological light intensity signals corresponding to the respective wavelengths and irradiation positions, and output to the A / D converter 105. The biological light intensity signal for each wavelength and irradiation position digitally converted by the A / D converter 105 is stored in a storage device (not shown) inside or outside the information processing apparatus 106. During or after the measurement, the information processing device 106 uses the biological light intensity signal stored in the storage device to calculate the relative change in the oxygenated and deoxygenated hemoglobin concentration obtained from the detection signal at each measurement position. The value of hemoglobin concentration change at each measurement position is calculated. However, since the method for calculating the relative change amount of the oxygenated and deoxygenated hemoglobin concentration from the detection signal at each measurement position is described in Document 1 and Document 2, detailed description thereof is omitted.

  Thereafter, the information processing device 106 calculates the value of hemoglobin concentration change in the measurement region by, for example, a well-known cubic spline interpolation and displays the result as a two-dimensional image on a display device (not shown), thereby creating a newborn It is possible to easily perform biological light measurement even on a subject that is difficult to perform measurement at a sitting position such as.

  Next, FIG. 2 is a front view for explaining the schematic configuration of the measurement probe 101 of the first embodiment, and FIG. 3 is a top view for explaining the schematic configuration of the measurement probe 101 of the first embodiment. 4 shows a side view for explaining a schematic configuration of the measurement probe 101 according to the first embodiment. Hereinafter, the structure and operation of the measurement probe 101 according to the first embodiment will be described with reference to FIGS. However, in FIG.3 and FIG.4, in order to simplify description, illustration of the probe case 210 attached to the shell plate 201 is abbreviate | omitted (refer FIG. 5).

  2 to 4, 201 is a shell plate, 202 is a belt, 203 is a subject fixing belt, 204 is an adjustment column, 205 is a column, 206 is a belt hook, 207 is an adjustment screw, 208 is a pillow base, and 209 is rubber. The foot, 211 is a probe holder, 212 is a silicone rubber sheet, 213 is a cable clamp, 214 is a subject, 215 is a hole formed in the belt 202, and 216 is a hair avoidance hole (adjustment hole).

  As is apparent from FIGS. 2 to 4, the measurement probe 101 of the first embodiment is an optical fiber fixing that fixes the distal end portions of the irradiation optical fiber 107 and the detection optical fiber 108 to a predetermined position on the head of the subject 214. And a support member that suspends and supports the head of the subject 214 supported by the optical fiber fixing member and the optical fiber fixing member.

  The optical fiber fixing member of Embodiment 1 includes a shell plate 201, a belt 202 for suspending the shell plate 201 on a support member, a subject fixing belt 203 for fixing the shell plate 201 to the head of the subject 214, and a subject. A silicon rubber sheet 212 is disposed between the head of the specimen 214 and the shell plate 201.

  As described above, the shell plate 201 of the first embodiment is based on a plastic sheet having a thickness of about 2 mm, for example, and the base is formed in a concave shape. This realizes a strength that does not cause deformation when the weight of the head of the subject 214 is supported. Sixteen probe holders 211 for fixing the irradiation optical fiber 107 and the detection optical fiber 108 to the shell plate 201 are attached to the shell plate 201. As is apparent from FIGS. 2 and 3, the attachment positions of the probe holder 211 are arranged in a lattice pattern along the surface shape of the shell plate 201. In the first embodiment, since a total of 16 optical fibers including the eight irradiation optical fibers 107 and the eight detection optical fibers 108 are used, 16 probe holders 211 are attached. However, the detailed structure of the probe holder 211 will be described later.

  Further, when performing biological light measurement, it is necessary to directly contact the tip portions of the irradiation and detection optical fibers 107 and 108 with the scalp which is the skin surface of the subject. In other words, if there is hair or the like between the optical fibers 107 and 108 and the scalp, the irradiation light or detection light is blocked by the hair, and the measurement accuracy is greatly reduced, or measurement can be performed. It is known that it will disappear. However, a plurality of hair avoidance holes 216 are formed in the shell plate 201 of the first embodiment together with the probe holder 211, and the hair of the subject 214 can be moved from the hair avoidance holes 216. The tip portions of the fibers 107 and 108 can be easily brought into contact with the scalp. That is, the contact work efficiency of the optical fibers 107 and 108 to the subject can be improved. Therefore, it is possible to improve the diagnostic efficiency in the living body optical measurement device according to the first embodiment.

  Further, since the hair avoidance hole 216 also functions as a vent hole during measurement, the burden on the subject can be reduced even when the measurement takes a long time.

  One hole for passing the belt 202 and the subject fixing belt 203 is provided at each end of the shell plate 201. In particular, in the shell plate 201 of the first embodiment, a hole for passing the belt 202 is formed so that a straight line connecting two holes for passing the belt 202 passes through the center of the shell plate 201 or near the center. Therefore, there is an effect that the stability when the head of the subject is placed on the shell plate 201 can be increased.

  A plurality of holes 215 are formed in the belt 202 along the extending direction thereof, and the shell plate 201 is selected by appropriately selecting the holes 215 to be passed through the belt hooking portion 206 attached to the front end portion of the adjustment column 204. Can be adjusted arbitrarily. At this time, since the shell plate 201 can be rotated around the body axis of the subject 214, the angle adjustment, that is, the inclination adjustment of the shell plate 201 according to the body position of the subject 214 can also be performed. Furthermore, the height of the shell plate 201 can be adjusted. However, the height of the shell plate 201 can be adjusted more easily by adjusting the degree of freedom of swinging of the shell plate 201 when adjusting the feed amount of the adjustment column 204 described later.

  The subject fixing belt 203 is formed of a resin-based material having relatively small elasticity, so that the head of the subject 214 is always tightened even when the measurement time is relatively long. It is possible to reduce the burden on the subject 214 due to continuing being performed. However, it goes without saying that even when the subject fixing belt 203 is formed of rubber or the like having high elasticity, the burden can be reduced by taking care not to increase the tightening force.

  The silicon rubber sheet 212 is a sheet for preventing the relatively hard shell plate 201 and the probe holder 211 from coming into direct contact with the scalp, and functions as a cushioning material, that is, a cushioning material and a slip stopper. In the silicon rubber sheet 212, holes (not shown) for passing the irradiation optical fiber 107 and the detection optical fiber 108 and corresponding to the hair avoidance holes are formed at positions corresponding to the mounting positions of the probe holder 211. The tip of the optical fiber is in contact with the scalp of the subject 214 through the hole.

  On the other hand, the support member according to the first embodiment includes a support column 205, an adjustment support column 204, a belt hooking portion 206, an adjustment screw 207, a pillow base 208, and rubber feet 209.

  As is clear from FIGS. 2 and 3, the pillow base 208 is based on, for example, an aluminum plate having a thickness of about 5 mm, and this base is formed in a U-shape so that the measurement probe 101 is attached to the head of the subject 214. The degree of freedom is ensured when placing in the section. Four rubber feet 209 are arranged at each corner on the back side of the pillow base 208, and the rubber feet 209 prevent the measurement probe 101 of the first embodiment from slipping during measurement. At the same time, vibration is prevented from propagating to the shell plate 201 and the positions of the optical fibers 107 and 108 are shifted.

  On two opposite sides of the pillow base 208, support columns 205 are attached to the surface side toward the upper surface. A cylindrical hole is formed in the column 205 along the extending direction, and an adjustment screw 207 is arranged from the side surface of the column 205 toward the center.

  One end of the adjustment column 204 is formed in a columnar shape that fits into a cylindrical hole formed in the column 205, and a plurality of grooves are formed on the side surface. That is, in the support member of the first embodiment, the height of the shell plate 201 can be arbitrarily adjusted by adjusting the feed amount of the adjustment column 204 from the column 205 and fitting the adjustment screw 207 in the groove. In addition, the inclination of the shell plate 201 can be adjusted. However, as described above, the inclination of the shell plate 201 can also be made by selecting the holes 215 formed in the belt 202.

  On the other hand, the other end of the adjustment column 204 is formed in a rectangular parallelepiped shape where at least all corners against which the belt 202 hits are chamfered. A belt hooking portion 206 is attached. As described above, in the first embodiment, the wear of the belt 202 is prevented by chamfering the corner on the side to which the belt 202 which is the other end of the adjustment column 204 is attached. However, the diameter of the belt hooking portion 206 is smaller than the diameter of the hole 215 formed in the belt 202, and as described above, the plurality of holes 215 formed in the belt 202 can be appropriately selected and adjusted. it can.

  As described above, in the support member of the first embodiment, the column 205 and the adjustment column 204 ensure a height for allowing the shell plate 201 to fish in the air.

  In addition, a well-known cable clamp 213 for bundling the irradiation optical fiber 107 and the detection optical fiber 108 is disposed on the support member of the first embodiment. The cable clamp 213 is disposed on the surface side in the short direction of the pillow base 208 in order to bundle the optical fibers 107 and 108 in the attaching direction of the belt 202 where the movement of the shell plate 201 is relatively small. Unnecessary force is prevented from being applied to 107 and 108.

  FIG. 5 is a longitudinal side view for explaining a schematic configuration of the probe holder 211 and the probe case according to the first embodiment. 210 is a probe case, 501 is a spring mechanism, and 502 is a case holding screw.

  As is clear from FIG. 5, the probe case 210 is formed in a cylindrical shape, and one side surface is formed so that its diameter gradually decreases as it approaches the tip. Further, a known spring mechanism 501 is built in the inner peripheral portion of each probe case 210, and an optical fiber is fixed to the movable side of the spring mechanism 501. At this time, the movable side of the spring mechanism that fixes the optical fiber is directed to push the tip end portion of the optical fiber to the side that is gradually narrowed of the probe case 210, that is, the side that contacts the subject 214. .

  Therefore, in the measurement probe 101 of the first embodiment, the scalp and the optical fiber are moved by moving the shell plate 201 up and down and left and right while pressing the shell case 201 against the head of the subject 214 with the probe case 210 mounted on the probe holder 211. The hair which is pinched between the tip portions of 107 and 108 can be easily avoided. That is, once the hair sandwiched between the scalp and the distal end portion of the optical fiber is detached with the movement of the shell plate 201, the optical fibers 107 and 108 are again haired by the pushing force of the spring mechanism 501. It is possible to prevent the optical fibers 107 and 108 from coming into contact with the scalp.

  On the other hand, the probe holder 211 is also formed in a cylindrical shape, one end is fixed to the shell plate 201, and the other end is provided with a case holding screw 502 for inserting the probe case 210 into the probe holder 211. Has been.

  In the first embodiment, the extending direction of the belt hooking portion 206 is configured to coincide with the extending direction of the support column 205. However, as in the belt hooking portion 206 in the second embodiment to be described later, the tip portion is It is possible to prevent the belt 202 from being easily displaced by bending it into an L shape.

  Further, in the first embodiment, for example, as shown in FIGS. 6A and 6B, a silicon rubber sheet 212 provided with a hole at the position of the probe holder 211 arranged on the shell plate 201 is replaced with a silicon rubber sheet 212 shown in FIG. As shown in FIGS. 7A and 7B, the probe holder 211 is arranged between the subject 214 and the shell plate 201. However, as shown in FIGS. Needless to say, the silicon rubber 5801 formed in the same C shape as the back surface side shape may be fixed to the back surface side of the probe holder 211 as shown in FIG. 7C. Needless to say, the silicon rubber 5801 and the silicon rubber sheet 212 may be other inclusions as long as they have elasticity such as sponge and have an anti-slip effect.

  As shown in FIGS. 6 (a) and 7 (a), a part of the probe holder 211 is notched and formed into an incomplete cylindrical shape so that the fixing hole of the probe holder 211 can be directly accessed. Even if an avoidance hole is not provided, the hair that has entered between the scalp and the optical fiber can be moved from this portion.

(Embodiment 2)
FIG. 8 is a front view for explaining a schematic configuration of the measurement probe 101 in the biological light measurement apparatus according to the second embodiment of the present invention, and FIG. 9 is a measurement probe in the biological light measurement apparatus according to the second embodiment of the present invention. FIG. 10 is a side view for explaining the schematic configuration of the measurement probe 101 in the biological optical measurement device according to the second embodiment of the present invention. However, in the following description, only the measurement probe 101 part having a configuration different from that of the biological light measurement apparatus according to the first embodiment will be described.

  8 to 10, 601 is a first pillow base, 602 is a second pillow base, 603 is a rubber plate, 604 is a mirror, 605 is a first silicon rubber plate, 606 is a second silicon rubber plate, 607. Is the first shell plate, 608 is the second shell plate, 609 is the first fixing belt, 610 is the second fixing belt, 611 is the probe case, 612 is the probe holder, 613 is the shell plate stand, and 614 is Shows hair avoidance holes.

  The optical fiber fixing member of the second embodiment includes a first silicon rubber plate 605, a second silicon rubber plate 606, a first shell plate 607, a second shell plate 608, a first fixing belt 609, and a second. The fixed belt 610 and the belt 202 are configured.

  Similar to the shell plate 201 of the first embodiment, the first shell plate 607 and the second shell plate 608 are based on, for example, a plastic sheet having a thickness of about 3 mm, and the base is formed in a concave shape. This realizes a strength that does not cause deformation when the weight of the subject's head (not shown) is supported.

  Similar to the shell plate 201 of the first embodiment, the first shell plate 607 and the second shell plate 608 include the irradiation optical fiber 107 and the detection optical fiber 108 with the first shell plate 607 and the second shell plate 607. Eight probe holders 612 for fixing and arranging on the shell plate 608 are attached. The attachment positions of these probe holders 612 are in a grid-like arrangement position along the surface shapes of the first shell plate 607 and the second shell plate 608 as in the first embodiment. Note that the living body light measurement apparatus according to the second embodiment also uses a total of 16 optical fibers including the eight irradiation optical fibers 107 and the eight detection optical fibers 108, so that the respective shell plates 607 and 608 are used. Eight probe holders 612 are attached to each. However, the detailed structure of the probe holder 612 of the second embodiment will be described later.

  The first shell plate 607 is formed with a hair avoidance hole 614 extending from the probe holder 612. By moving the hair of the subject (not shown) from the hair avoidance hole 614, the first shell plate 607 is moved to the first shell plate 607. It is possible to improve the working efficiency for bringing the tip portions of the attached irradiation and detection optical fibers 107 and 108 into direct contact with the scalp of the subject. Therefore, it is possible to improve the diagnostic efficiency when using the biological light measurement device of the second embodiment. In addition, the hair avoidance hole 614 functions as a vent hole during measurement, similar to the hair avoidance hole 216 of the first embodiment, so even if the measurement takes a long time, This burden can be reduced. In Embodiment 2, since the back of the subject (not shown), that is, the lower surface side is arranged on the first shell plate 607, the hair avoiding hole 614 is provided only in the first shell plate 607 where workability is lowered. It was. However, it goes without saying that the hair avoidance hole 614 may be provided in the second shell plate 608.

  At both ends of the first shell plate 607, one hole for passing the belt 202, the first fixing belt 609, and the second fixing belt 610 is provided. On the other hand, one hole for passing the first fixing belt 609 and the second fixing belt 610 is provided at both ends of the second shell plate 608. Also in the second embodiment, as in the first embodiment, a hole for passing the belt 202 is formed so as to pass through the center of the first shell plate 607 that supports the head of the subject or near the center. Has been.

  Also in the second embodiment, the belt 202 is formed with a plurality of holes 215 along the extending direction thereof, and the hole 215 that passes through the belt hooking portion 206 attached to the tip end portion of the adjustment column 204 is formed. By appropriately selecting, the swing amount of the first shell plate 607 can be arbitrarily adjusted. At this time, since the first shell plate 607 can be rotated around the body axis of the subject, the inclination of the first shell plate 607 can be adjusted according to the posture of the subject. Furthermore, the height of the first shell plate 607 can be adjusted. However, the height of the first shell plate 607 is adjusted by adjusting the feed amount of the adjustment column 204, as in the first embodiment. Becomes easy.

  The first fixing belt 609 and the second fixing belt 610 are formed of a resin material having relatively low elasticity, like the subject fixing belt 203 of the first embodiment. Even when it takes a long time, it is possible to reduce the burden on the subject due to the fact that the head of the subject is always tightened. However, even when the first fixing belt 609 and the second fixing belt 610 are formed of rubber having high elasticity, the burden can be reduced by taking care not to increase the tightening force. Needless to say.

  By the first and second fixing belts 609 and 610, the first and second shell plates 607 and 608 are fixed to a subject (not shown). And it can prevent that the contact position of the front-end | tip position of the optical fibers 107 and 108 for a detection and a scalp shifts | deviates easily. In particular, in the second embodiment, since the first and second shell plates 607 and 608 are fixed by the two fixing belts of the first and second fixing belts 609 and 610, the displacement of the contact position is further increased. There is an effect that it is difficult to occur.

  The first silicon rubber plate 605 is a plate for preventing the hard first and second fixing belts 609 and 610 from hitting the subject's ears or the like because of its relatively low elasticity, and the first silicon rubber plate 605 has first ends at both ends. In addition, holes for passing the second fixing belts 609 and 610 are formed.

  The second silicon rubber plate 606 is a plate for preventing the relatively hard first shell plate 607 and probe holder 612 from coming into direct contact with the scalp, like the silicon rubber sheet 212 of the first embodiment. It functions as a cushioning material, that is, a cushioning material and an antislip material. In the second silicon rubber plate 606, a hole (not shown) for passing the irradiation optical fiber 107 and the detection optical fiber 108 is formed at a position corresponding to the position of the probe holder 612, and the optical fiber is passed through the hole. The tip is in contact with the scalp of the subject.

  As described above, in the biological light measurement using the measurement probe 101 of the second embodiment, the measurement obtained from the light passing through the living body collected by the detection optical fiber 108 arranged on the first shell plate 607. A function related to the back of the head can be measured from the two-dimensional image of the hemoglobin concentration change value in the region. On the other hand, from the two-dimensional image of the hemoglobin concentration change value in the measurement region obtained from the light passing through the living body collected by the detection optical fiber 108 arranged on the second shell plate 608, it is related to the frontal region. Function can be measured. Therefore, in the living body optical measurement device using the measurement probe 101 of the second embodiment, for example, a thrombus formed during surgery (particularly, cardiac surgery) is carried into the brain and clogs blood vessels in the brain. It is suitable for monitoring the state of the brain in a wide range.

  On the other hand, the support member of the second embodiment includes the first pillow base 601, the second pillow base 602, the rubber plate in addition to the support column 205, the adjustment support column 204, the belt hooking portion 206, and the adjustment screw 207 of the first embodiment. 603, mirror 604, and shell plate stand 613.

  As is apparent from FIGS. 8, 9, and 10, the first pillow base 601 is based on an aluminum plate having a thickness of about 5 mm, for example, like the pillow base 208 of the first embodiment. By forming it in the shape of a letter, the degree of freedom when placing the measurement probe 101 on the head of the subject is secured.

  The second pillow base 602 is made of, for example, an aluminum plate having a thickness of about 3 mm as a base, and the base is formed in a rectangular shape, whereby the first pillow base 601 and the mirror 604 are placed on the upper surface side of the second pillow base 602. The area to be placed in is secured. Three rubber plates 603 are arranged on the back side of the second pillow base 602 along the first pillow base 601, and the measurement is performed during measurement as in the case of the rubber feet 209 of the first embodiment. This prevents the measurement probe 101 of Form 2 from slipping and prevents the vibration from propagating to the first shell plate 607 and shifting the positions of the optical fibers 107 and 108.

  As is apparent from FIGS. 8 and 10, a shell plate holder for temporarily storing the second shell plate 608 on the upper surface of the first pillow base 601 when the measurement probe 101 is not used or the like. A table 613 is arranged. The shell plate pedestal 613 is formed by bending a columnar body extending from the upper surface of the first pillow base 601 in the upper surface direction in a direction substantially parallel to the first shell plate 607, and then repositioning the tip portion thereof again. A columnar body bent in the upper surface direction is provided in parallel with the first pillow base 601.

  The mirror 604 disposed on the upper surface of the second pillow base 602 is used for confirmation when avoiding hair in a state where the head of the subject is mounted on the first shell plate 607, and an optical fiber is securely attached to the scalp. Can be brought into contact with each other, and the work efficiency can be improved.

  FIGS. 11A and 11B are diagrams for explaining schematic configurations of the probe holder 612 and the probe case 611 according to the second embodiment. In particular, FIG. 11A shows the probe holder 612 according to the second embodiment. FIG. 11B is a front view of the probe holder 612 and the probe case 611 according to the second embodiment.

  In FIG. 11A, reference numeral 901 denotes a spring mechanism, 902 denotes a first case holding screw, and 903 denotes a second case holding screw.

  As is clear from FIG. 11A, the probe case 611 of the second embodiment is formed in a cylindrical shape, and one side surface is formed so that its diameter gradually decreases as it approaches the tip. In addition, a known spring mechanism 901 is built in the inner peripheral portion of the probe case 611. One end of the spring mechanism 901 is fixed to the probe case 611 body, and the other end is a movable part that holds the optical fiber. It is fixed to. However, the movable part that sandwiches the optical fiber is oriented such that the tip of the optical fiber is pushed out to the side where the probe case 611 is gradually formed, that is, the side that contacts the subject 214. Therefore, in the state where the probe case 611 is attached to the probe holder 612, a force that always pushes the optical fiber to the concave surface side of the first and second shell plates 607 and 608 is applied as in the first embodiment. It becomes.

  Further, the probe case 611 of the second embodiment is provided with a groove at a position facing the outer peripheral surface, and the tip portions of the first and second case holding screws 902 and 903 arranged in the probe holder 612 are provided. It is comprised so that it may insert in the groove | channel formed in the outer peripheral surface.

  On the other hand, the probe holder 612 of the second embodiment has a notch formed in a cylindrical part, and the notch is fixed so as to coincide with the notch of the first shell plate 607. Further, as described above, the first and second case holding screws 902 and 903 are arranged in the probe holder 612 at positions facing the outer peripheral surface. The first and second case holding screws 902 and 903 are formed in such a length that the tip portions protrude from the inner peripheral surface of the probe holder 612, and the tip portions are formed on the outer peripheral surface of the probe case 611. The probe case 611 is held in the probe holder 612 by being inserted into the groove.

  In the second embodiment, since the diameter of the outer peripheral surface of the probe case 611 is configured to be smaller than the diameter of the inner peripheral surface of the probe holder 612, the tip portions of the first and second case holding screws 902 and 903 are formed. The tip portion of the probe case 611, that is, the tip portion of the optical fiber, is supported so as to be movable in a direction perpendicular to the straight line connecting the first and second case holding screws 902 and 903, with the position where the is inserted as a fulcrum. Therefore, in the second embodiment, after the first and second shell plates 607 and 608 are attached to the subject, the hair can be moved in the notch direction provided in the shell plates 607 and 608. In addition, after attaching the probe case 611, that is, the optical fiber to the probe holder 612 disposed on the first and second shell plates 607 and 608, the probe case 611 can be swung around the fulcrum. That is, in the second embodiment, it is possible to swing the tip portions of the irradiation and detection optical fibers 107 and 108 in a direction orthogonal to a straight line connecting the first and second case holding screws 902 and 903. . Therefore, even if the subject has a lot of hair compared to a newborn baby or the like, the hair that is sandwiched between the scalp and the optical fibers 107 and 108 can be easily avoided. As a result, it is possible to improve work efficiency for bringing the tip portions of the irradiation and detection optical fibers 107 and 108 into direct contact with predetermined positions on the scalp of the subject. Therefore, the diagnostic efficiency of the subject by the living body optical measurement device according to the second embodiment can be improved.

  The swing direction of the notch and the probe case 611 may be any direction, but it is needless to say that it is most desirable to set it to 90 °.

(Embodiment 3)
FIG. 12 is a longitudinal side view for explaining a schematic configuration of the measurement probe 101 in the biological light measurement apparatus according to the third embodiment of the present invention. FIG. 13 shows the measurement probe 101 in the biological light measurement apparatus according to the third embodiment. FIG. 14 is a top view for explaining the schematic configuration, and FIG. 14 is a side view for explaining the schematic configuration of the measurement probe 101 in the biological light measurement device of the third embodiment. However, in the following description, only the measurement probe 101 part having a configuration different from that of the biological light measurement apparatus according to the first embodiment will be described. In order to simplify the description, a case where there are two irradiation optical fibers 107 and two detection optical fibers 108 will be described.

  12-14, 1001 is a case, 1002 is a probe holder, 1003 is a probe case, and 1004 is a case holding screw.

  As is apparent from FIGS. 12 to 14, the measurement probe 101 according to the third embodiment is a case where an object (not shown) performs measurement in the lying position by placing the probe holder 1002 and the probe case 1003 in the case 1001. In addition, the probe case 1003 and the irradiation and detection optical fibers 107 and 108 are configured not to be subjected to unnecessary force.

  The upper surface of the case 1001 is formed in a concave shape like the shell plate 201 of the first embodiment, and the probe holder 1002 is disposed on the upper surface.

  In this way, by projecting the tip portions of the irradiation and detection optical fibers 107 and 108 from the upper surface of the case 1001, the head of the subject not shown in the lying position is supported, and the scalp and the optical fibers 107 and 108 are supported. The contact position can be easily determined.

  However, in Embodiment 3, the surface facing the upper surface of the case 1001 on which the probe holder 1002 is disposed is a flat surface, but the present invention is not limited to this, and as shown in FIG. By forming the surface into a curved surface or a semi-cylindrical shape, the case 1001 main body, that is, the tip portions of the irradiation and detection optical fibers 107 and 108 can be moved in accordance with the movement of the head of the subject (not shown). It is possible to prevent the detection position from being shifted due to the movement of the head of the subject. At this time, the first and second subject fixing belts 2002 and 2003 that are belts for fixing the measurement probe 101 of the third embodiment to the subject are provided on the shell plate 2001 that is the upper surface of the case 1001. Thus, the followability of the measurement probe 101 with respect to the subject 214 can be further improved, so that the performance of preventing the displacement of the detection position due to the movement of the head of the subject can be further improved. Further, by forming the shell plate 2001 portion from a relatively soft material, it is possible to greatly reduce the sense of incongruity when the measurement probe 101 of Embodiment 3 is used for biological light measurement by an infant. Furthermore, when the measurement probe 101 according to the third embodiment is used for an infant, the measurement probe 101 can easily follow the movement around the body axis, which is the main movement of the infant. The displacement of the detection position due to the movement of the head can be prevented.

(Embodiment 4)
FIG. 16 is a diagram for explaining a schematic configuration of the biological light measurement device according to the fourth embodiment of the present invention, and reference numeral 1301 denotes a stimulation device. However, in the following description, only the configuration and operation of the stimulation device 1301 that are different in configuration from the biological light measurement device of the first embodiment will be described.

  The biological light measurement apparatus according to the fourth embodiment includes, for example, a stimulation apparatus 1301 that performs predetermined display output and audio output based on a video signal and an audio signal that are control signals from the information processing apparatus 106 according to the first embodiment. Have. Therefore, the brain activity status can be measured while applying the video stimulus and the voice stimulus to the subject (not shown), so that more accurate measurement is possible. Note that the video stimulus and the voice stimulus given to the subject may be given in synchronization with the measurement, and in this case, the measurement with high measurement accuracy from when the stimulus is given until the reaction is detected can be performed. However, as a video stimulus, various images can be displayed in addition to a general flash.

  FIG. 17 is a diagram for explaining a schematic configuration of the stimulation device in the biological light measurement device according to the fourth embodiment. 1401 is a display unit, 1402 is a speaker, 1403 is a flexible tube, and 1404 is a stand.

  The display unit 1401 is composed of, for example, a known liquid crystal display device, and a known speaker 1402 that outputs sound is disposed below the liquid crystal display device. The display unit 1401 is attached to the stand 1404 via a flexible tube 1403. Therefore, for example, as shown in FIG. 18, it is possible to easily give a stimulus to the head of the subject together with the measurement probe 101 of the first and second embodiments. Measurements for newborns and the like can also be performed.

  In this case, in the stimulation apparatus 1301 of Embodiment 4, since the display unit 1401 and the stand 1404 are connected via the flexible tube 1403, the position and angle of the display unit 1401 with respect to a subject (not shown) can be easily changed. Is possible. Therefore, the display unit 1401 can be optimally set for the subject even when measurement is performed with various changes in the size of the subject's head and the measurement posture.

  In this case, as described above, the stimulus given to the newborn and the brain activity obtained by the stimulus can be measured synchronously, so that the diagnostic efficiency can be improved.

  In the fourth embodiment, the light stimulus and the sound stimulus are only given. However, the present invention is not limited to this, and a plurality of fragrances that serve as odor bases are prepared in advance. By mixing based on an instruction from the information processing apparatus 106 and releasing it from the front surface of the display unit 1401, it is also possible to perform synchronous measurement of stimulation with respect to olfaction. In addition, a plurality of types of solutions serving as taste bases are prepared in advance, and the solutions are mixed based on an instruction from the information processing apparatus 106 and given to the subject via a tube or the like provided on the front surface of the display unit 1401. Thus, it is possible to perform synchronous measurement of stimuli with respect to taste.

  In the fourth embodiment, a liquid crystal display device is used for the display unit 1401 which is a light stimulus generation unit. However, the present invention is not limited to this. For example, a well-known light bulb, strobe device, projector device, It goes without saying that a backlight device or the like used for a liquid crystal display device may be used. In particular, when an infant or the like is measured as a subject, it is difficult to gaze at the display unit 1401, and thus a light bulb, strobe device, or projector device capable of relatively high-capacity light emission is suitable.

  Furthermore, in the fourth embodiment, the stand 1404 is arranged at one end of the flexible tube 1403. However, the present invention is not limited to this. For example, a known clamp is arranged at one end of the flexible tube 1403. Since the subject 214 can be easily attached to a bed on which the subject 214 is set or a handrail placed on the bed, the display unit 1401 can be placed at a position most suitable for the subject.

(Embodiment 5)
FIG. 19 is a diagram for explaining a schematic configuration of a part of the measurement probe 101 in the living body optical measurement apparatus according to the fifth embodiment of the present invention, in which 1601 indicates a guide rail and 1602 indicates a belt. However, in the following description, only the configuration of the adjustment column 204 having a configuration different from that of the measurement probe 101 of the first embodiment will be described.

  As shown in FIG. 19, in the measurement probe 101 of the fifth embodiment, a guide rail 1601 formed in parallel with the pillow base 208 is disposed at the other end of the adjustment column 204. The guide rail 1601 is formed so that the extending direction thereof is parallel to the body axis direction of the subject 214 when the measurement probe 101 of the fifth embodiment is set to the subject 214 (not shown). . Specifically, a guide rail 1601 is formed in parallel with two sides on which the support column 205 is formed in a pillow base 208 formed in a U-shape.

  The guide rail 1601 is formed with a belt hooking portion (not shown) that is movable in the extending direction. The belt hook portion is hooked in the hole 215 formed in the belt 1602.

  Similar to the first embodiment, a shell plate 201 (not shown) is disposed at one end of the belt 1602, and a plurality of holes 215 are formed at the other end. Therefore, also in the measurement probe 101 of the fifth embodiment, by supporting the other end of the belt 1602, the shell plate 201 can be swung back and forth, right and left, that is, the body axis direction of the subject and the direction perpendicular to the body axis. It is the structure which supports so that it may become. In particular, in the measurement probe 101 of the fifth embodiment, the belt 1602 that suspends the shell plate 201 that supports the head of the subject 214 from both sides is supported so as to be movable in the body axis direction. The displacement of the contact position between the optical fiber and the scalp accompanying the movement in the front-rear direction can be prevented.

(Embodiment 6)
FIG. 20 is a diagram for explaining a schematic configuration of the measurement probe 101 in the biological optical measurement apparatus according to the sixth embodiment of the present invention, and reference numeral 1701 denotes a second subject fixing belt. However, in the following description, only the configuration of the subject fixing belt 1701 having a configuration different from that of the measurement probe 101 of the first embodiment will be described.

  As shown in FIG. 20, in the measurement probe 101 of the sixth embodiment, the second subject formed of a resin material having relatively low elasticity, like the subject fixing belt 203 of the first embodiment. A fixed belt 1701 is disposed.

  In particular, in the sixth embodiment, a hole for passing the subject fixing belt 203 is formed on one side with respect to a hole for passing the belt 202 arranged at both ends of the shell plate 201. On the other side, a hole for passing the second subject fixing belt 1701 is formed. As described above, in the measurement probe 101 according to the sixth embodiment, for example, the subject fixing belt 203 is passed through the forehead side of the subject 214 and the second subject fixing belt 1701 is passed through the jaw portion of the subject 214. Thus, the shell plate 201 can be fixed to the subject 214 at two locations.

  As a result, it is possible to prevent the displacement of the contact position between the optical fiber and the scalp caused by the displacement of the shell plate 201 due to the swing of the subject 214.

(Embodiment 7)
FIGS. 21A and 21B are diagrams for explaining a schematic configuration of the measurement probe 101 in the biological light measurement apparatus according to the seventh embodiment of the present invention. In particular, FIG. 21A shows the first embodiment. It is a figure for demonstrating the variation schematic structure of the probe case 210 of FIG. 21, FIG.21 (b) is a figure for demonstrating the schematic structure of the probe case of Embodiment 7, and a probe holder. However, in the following description, only the configuration of the probe case and the probe holder, which is different in configuration from the measurement probe 101 of Embodiment 1, will be described.

  As is clear from FIG. 21A, in the variation of the probe case 210 of the first embodiment, a suspension pipe 1801 made of, for example, stainless steel is disposed at the position where the irradiation or detection optical fibers 107 and 108 are taken out. ing. The suspension pipe 1801 is bent at, for example, 90 degrees, and is configured to pass the irradiation or detection optical fibers 107 and 108 through the suspension pipe 1801. As described above, by adopting a configuration in which the optical fibers 107 and 108 are covered with the suspension pipe 1801, in the variation of the probe case 210 of the first embodiment, the irradiation is performed when the measurement probe 101 is arranged on the back of the subject 214 (not shown). The optical fibers 107 and 108 for use and detection are prevented from being damaged due to extreme deformation.

  On the other hand, in the seventh embodiment shown in FIG. 21B, a known prism 1803 is arranged at the tip of the detection or irradiation optical fibers 107 and 108. The prism 1803 is formed such that one incident / exit surface and the other incident / exit surface form 90 degrees, and the ends of the irradiation or detection optical fibers 107 and 108 are arranged on the other incident / exit surface. Has been. One entrance / exit surface of the prism 1803 is disposed so as to contact the surface of the subject 214. That is, the one incident / exit surface side of the prism 1803 is held by the probe holder 1802 of the seventh embodiment. Therefore, in the seventh embodiment, the height H2 of the probe case can be made smaller than the height H1 of the probe case of the first embodiment and its variations. As a result, the measurement probe 101 according to the seventh embodiment can reduce the height of the measurement probe 101 during measurement. Therefore, when the measurement probe 101 is placed on the back of the subject 214, the subject The load on 214 can be reduced.

  Needless to say, the angle formed by one of the entrance and exit surfaces of the prism 1803 and the other entrance and exit surface is not limited to 90 degrees, and may be formed at an arbitrary angle.

(Embodiment 8)
22 (a) and 22 (b) are diagrams for explaining a schematic configuration of the measurement probe 101 in the biological light measurement apparatus according to the eighth embodiment of the present invention. In particular, FIG. 22 (a) shows the eighth embodiment. FIG. 22B is a rear view of the measurement probe 101 according to the eighth embodiment. However, in the following description, only the configuration of the measurement probe 101, which is different from the configuration of the biological light measurement apparatus of the first embodiment, will be described.

  22A and 22B, reference numeral 1901 denotes a shell plate, 1902 denotes a first roller, 1903 denotes a second roller, 1904 denotes a third roller, 1905 denotes a case, and 1906 denotes a ball tire.

  As is clear from FIG. 22A, the measurement probe 101 of the eighth embodiment has a first roller 1902 and a second roller 1903 arranged on two adjacent sides of the side surface of the case 1901, respectively. Yes. Further, a third roller 1904 is disposed at an apex portion where two sides where the first and second rollers 1901 and 1902 are not disposed are in contact with each other.

  Here, in the eighth embodiment, the shell plate 1901 is placed on the first to third rollers 1902 to 1904, so that the first to third rollers 1902 to 1904 are used to form the shell plate 1901. It is the composition which supports. As a result, in the measurement probe 101 according to the eighth embodiment, the degree of freedom of movement of the shell plate 1901 relative to the case 1905 can be increased, resulting in the displacement of the shell plate 1901 accompanying the swing of the subject 214. The performance of preventing the displacement of the contact position between the optical fiber and the scalp can be improved.

  In the measurement probe 101 of the eighth embodiment, four well-known ball tires 1906 are respectively disposed on the back surface of the case 1905. Therefore, the subject 214 (not shown) is placed on the recumbent position and the back of the head of the eighth embodiment. When the measurement probe 101 is set, the measurement probe 101 can be moved following the subject 214 even if the subject 214 moves in parallel with the surface on which the subject 214 is arranged. As a result, it is possible to improve the performance of preventing the displacement of the contact position between the optical fiber and the scalp due to the displacement of the shell plate 1901 accompanying the swing of the subject 214.

  The measurement probe 101 according to the eighth embodiment can move the position of the shell plate 1901 relative to the case 1905 and can move the case 1905 main body. However, the measurement probe 101 is not limited to this. Needless to say, the tire plate 1901 may be moved with respect to the case 1905 without the tire 1906. Needless to say, the shell plate 1901 may be fixed to the case 1905 and the ball tire 1906 may be disposed on the back surface of the case 1905 as in the third embodiment.

  Further, by providing a known vertical mechanism for moving the first to third rollers 1902 to 1904 in the vertical direction, the angle of the shell plate 1901 with respect to the measurement site can be changed. Further, by moving the first to third rollers 1902 to 1904 in the same manner, the height of the shell plate 1901 can be adjusted according to the height of the neck that varies depending on the individual difference of the subject 214. Further, by providing a subject fixing belt for fixing the shell plate 1901 to the subject 214 at both ends of the shell plate 1901, the optical fiber and the scalp caused by the displacement of the shell plate 1901 accompanying the swing of the subject 214 are provided. It is possible to further improve the performance of preventing the displacement of the contact position.

(Embodiment 9)
FIGS. 23A and 23B are diagrams for explaining a schematic configuration of the measurement probe 101 in the biological optical measurement device according to the ninth embodiment of the present invention. FIG. 23A is a measurement according to the ninth embodiment. FIG. 23B is a perspective view of the probe 101, and FIG. 23B is a diagram for explaining the detailed structure of the shell plate 2104 portion of the measurement probe 101 of the ninth embodiment. However, in the following description, only the configuration of the measurement probe 101, which is different from the configuration of the biological light measurement apparatus of the first embodiment, will be described.

  23A and 23B, 2101 is a case, 2102 is a comforter, 2103 is a foot of the case, and 2104 is a shell plate.

  As is clear from FIG. 23A, the measurement probe 101 of the ninth embodiment has a case 2101 formed in a crib shape. Further, in the measurement probe 101 of the ninth embodiment, a comforter 2102 that is hung on the subject 214 is provided so as to reduce the movement of the subject 214 placed on the case 2101. Here, for example, by providing means for fixing the comforter 2102 to the case 2101, the subject 214 can be fixed to the case 2101.

  In addition, four case legs 2103 are arranged on the back surface of the case 2101 to prevent the case 2101 from easily falling over even when the subject 214 moves.

  Next, a detailed configuration of the measurement probe 101 according to the ninth embodiment will be described with reference to FIG.

  In the measurement probe 101 of the ninth embodiment, the shell plate 2104 is disposed at a position corresponding to the back of the head when the subject 214 is laid upward. A subject fixing belt 2105 for fixing the head of the subject 214 is disposed on the shell plate 2104. Similar to the measurement probe 101 of the first embodiment, the subject fixing belt 2105 is attached to the shell plate 2104. It is configured to hit the forehead of 214. Further, for example, the probe holder shown in the first embodiment is arranged on the shell plate 2104, and a probe case is attached to the probe holder.

  As described above, in the measurement probe 101 of the ninth embodiment, the case 2101 is formed in a crib shape, thereby restraining the movement of the subject 214 and at the position corresponding to the back of the head or other measurement position. And fixing the shell plate 2104 to the head of the subject 214 with the subject fixing belt 2105 can prevent displacement of the contact position between the optical fiber and the scalp.

(Embodiment 10)
FIGS. 24A and 24B are views for explaining a schematic configuration of the measurement probe 101 in the biological light measurement apparatus according to the tenth embodiment of the present invention. FIG. 24A shows only the head of the subject. FIG. 24B is a diagram for explaining the schematic configuration of the measurement probe 101 that covers the upper half of the subject. However, in the following description, only the configuration of the measurement probe 101, which is different from the configuration of the biological light measurement apparatus of the first embodiment, will be described.

  In FIG. 24A, 2201 denotes a shell plate, 2202 denotes a subject fixing belt, and 2203 denotes a jaw plate.

  As shown in FIG. 24A, in the measurement probe 101 of the tenth embodiment, the shell plate 2201 is formed in a cap shape, and the material thereof is, for example, cloth or rubber. Similar to the shell plate of the first embodiment, the probe holder 211 is disposed on the shell plate 2201. By attaching the probe case 210 to the probe holder 211, the optical fibers 107 and 108 for irradiation and detection are used. The tip portion of this is brought into contact with the epidermis (skin surface) of the subject 214. Moreover, in the measurement probe 101 of the tenth embodiment, the shell plate 2201 is formed so as to cover the hair portion of the subject 214, so that it is disposed at the lower part of the shell plate 2201, that is, at a position close to the neck of the subject 214. A subject fixing belt 2202 is disposed below the shell plate 2201 in order to improve the restraining performance of the portion and prevent the displacement of the contact position between the optical fiber and the skin.

  However, since the subject fixing belt 2202 needs to be hung on the jaw portion of the subject 214, it is necessary to prevent the subject fixing belt 2202 from being displaced and to reduce discomfort given to the subject 214. . For this purpose, in the measurement probe 101 of the tenth embodiment, a chin plate 2203 is disposed at a portion of the subject fixing belt 2202 that contacts the jaw of the subject 214.

  On the other hand, as shown in FIG. 24B, the shell plate 2204 is formed so as to be worn by the subject 214 like a suit, so that the portion where the probe holder 211 serving as the shell plate 2204 is disposed and the subject 214 are arranged. Since the displacement can be prevented, the displacement of the contact position between the optical fiber and the scalp can be prevented.

  In the case where the shell plates 2201 and 2204 are formed of cloth, the contact of the irradiation and detection optical fibers 107 and 108 with the surface of the subject by using a stretchable cloth, that is, the optical fiber and The performance of preventing the displacement of the contact position with the epidermis can be improved.

  In addition, when the measurement probe 101 is formed in a suit shape as shown in FIG. 24B, the attachment / detachment of the measurement probe 101 can be facilitated by providing an opening / closing part provided with a fastener or the like.

(Embodiment 11)
FIG. 25 is a diagram for explaining a schematic configuration of the measurement probe 101 in the biological optical measurement device according to the eleventh embodiment of the present invention. 2301 is a pillow base, 2302 is a side column, 2303 is a horizontal column, and 2304 is a chin presser. Reference numeral 2305 denotes a horizontal belt, and 2306 denotes a shell plate. However, in the following description, only the configuration of the measurement probe 101, which is different from the configuration of the biological light measurement apparatus of the first embodiment, will be described.

  As shown in FIG. 25, the measurement probe 101 according to the eleventh embodiment includes a restraining member that restrains the subject 214 at a predetermined position, and irradiation and detection (not shown) on the measurement site of the subject 214 restrained by the restraining member. And an optical fiber fixing member for fixing the tip portions of the optical fibers 107 and 108 for use.

  As is clear from FIG. 25, in the restraining member of the eleventh embodiment, the two pillow bases 2301 and the side struts 2302 are each formed in a T shape, and the side struts 2302 are connected to each other by the horizontal struts 2303. It is formed by. At this time, in the restraining member of the eleventh embodiment, the jaw holder 2304 for fixing the jaw of the subject 214 is arranged on the horizontal support 2303, and the head position is fixed when the subject 214 is restrained. It has become. In addition, a restraining belt (not shown) for restraining the subject 214 to the restraining member is disposed on the restraining member of the eleventh embodiment.

  In the restraining member of the measurement probe 101 according to the eleventh embodiment, a horizontal belt 2305 is stretched around two side columns 2302, and a shell plate 2306 is attached to the horizontal belt 2305. Note that the configuration of the shell plate 2306 is the same as the configuration of the shell plate of the first embodiment described above, and thus detailed description thereof is omitted.

  In particular, in the restraining member of the measurement probe 101 according to the eleventh embodiment, the head restraint belt that restrains the head of the subject 214 and the body restraint belt that restrains the body part of the subject 214 to the horizontal support 2303. By arranging the restraining belt, restraining performance can be improved.

  In addition, by disposing cushion materials on the surfaces of the pillow base 2301, the side struts 2302 and the horizontal struts 2303 constituting the restraining member of the eleventh embodiment, there is a sense of incongruity when the subject 214 is restrained by the restraining member. It can be reduced.

(Embodiment 12)
FIG. 26 is a diagram for explaining a schematic configuration of the measurement probe 101 in the biological optical measurement device according to the twelfth embodiment of the present invention. 2401 is a shell plate, 2402 is an adjustment column, 2403 is a horizontal column, and 2404 is horizontal adjustment. A screw 2405 indicates a hook pin. However, in the following description, only the configuration of the measurement probe 101, which is different from the configuration of the biological light measurement apparatus of the first embodiment, will be described.

  As shown in FIG. 26, the measurement probe 101 of the twelfth embodiment is supported by the shell plate 2401 serving as an optical fiber fixing member, the shell plate 2401, and the shell plate 2401 in the same manner as the measurement probe 101 of the first embodiment. And a support member that supports the head of the subject 214 to be suspended.

  The shell plate 2401 of the twelfth embodiment is made of a cloth having flexibility and strength, such as a cloth made of polyester, vinyl leather, or the like. One hole is formed at each end of the shell plate 2401, and the shell plate 2401 is suspended and supported by passing a hook pin 2405 attached to one end of the horizontal support 2403 through the hole. Details of the shell plate 2401 of the twelfth embodiment will be described later.

  As in the support member of the first embodiment, the support member of the twelfth embodiment has the support column 205 on the upper surface side of two opposing sides of the pillow base 208 formed in a U-shape. Each is attached. A columnar hole is formed in the column 205 along the extending direction, and an adjustment screw 207 is arranged from the side surface of the column 205 toward the center.

  Next, a different part from Embodiment 1 is demonstrated based on FIG.

  One end of the adjustment column 2402 of the twelfth embodiment is formed in a columnar shape, and is inserted into a hole provided in the column 205. On the other hand, a cylindrical hole perpendicular to the extending direction is formed at the other end of the adjustment column 2402, and a horizontal adjustment screw 2404 extends from the upper part of the adjustment column 2402 toward the center of the columnar hole. Has been placed. A horizontal column 2403 is passed through the hole formed in the adjustment column 2402 and is movable in the center axis direction of the hole, that is, the extending direction of the horizontal column 2403. However, in the measurement probe 101 of the twelfth embodiment, the movement of the horizontal column 2403 is limited by tightening the horizontal adjustment screw 2404, that is, the interval between the horizontally arranged horizontal columns 2403 can be set to an arbitrary interval. It has a possible configuration.

  As described above, in the measurement probe 101 according to the twelfth embodiment, a cloth having a width capable of covering the head of the subject 214 is used for the shell plate 2401, and both ends of the shell plate 2401 are suspended and supported by the support members. Thus, even when the subject 214 moves, it is possible to prevent the contact position between the optical fiber and the scalp from shifting.

  FIGS. 27A and 27B are diagrams for explaining the detailed configuration of the shell plate 2401 according to the twelfth embodiment. In particular, FIG. 27A is a front view for explaining the detailed configuration of the shell plate 2401. FIG. 27B is a side view for explaining the detailed configuration of the shell plate 2401.

  As shown in FIG. 27A, the shell plate 2401 of the twelfth embodiment is formed so as to wrap the head of the subject 214. A probe socket (holder) (not shown) is arranged at the center portion of the shell plate 2401, and when the subject 214 is measured upward, the tip portion of the probe case 210, that is, the irradiation and detection optical fibers 107 and 108. The distal end portion is configured to come into contact with the back of the subject 214.

  Further, as shown in FIG. 27B, holes 2406 for passing through hook pins 2405 attached to one end of each horizontal column 2403 are provided at both ends of the shell plate 2401. In order to increase the strength, a well-known caulking 2407 is disposed in each hole 2406.

  FIGS. 28A, 28B to 31A, 31B are diagrams for explaining the relationship between the biological light measurement position and the probe holder position. In particular, FIGS. FIG. 28A is a diagram for explaining the position of the probe holder formed on the shell plate 2401, and FIGS. 28B to 31B are diagrams for explaining the relationship between the biological light measurement position and the body position of the subject. FIG.

  As shown in FIG. 28A, by arranging 4 × 4 probe holders 211 in the central portion of the shell plate 2401, a shell plate 2401 suitable for biological light measurement in the back of the subject 214 is configured. Can do. When biological light measurement is performed using the shell plate 2401 shown in FIG. 28A, the probe holder 211 is suspended by supporting the head of the subject 214 upward as shown in FIG. 28B. It is possible to bring the irradiation and detection optical fibers 107 and 108 (not shown), which are the distal end portion of the probe case 210 disposed in the position, into contact with the back of the subject 214.

  As shown in FIG. 29A, by arranging 3 × 3 probe holders 211 on the left and right portions of the shell plate 2401, respectively, a shell plate 2401 suitable for simultaneously measuring the temporal region of the subject 214 on the left and right sides. Can be configured. When biological light measurement is performed using the shell plate 2401 shown in FIG. 29A, the probe holder 211 is suspended by supporting the head of the subject 214 upward as shown in FIG. 29B. It is possible to simultaneously bring the irradiation and detection optical fibers 107 and 108 (not shown), which are the distal end portion of the probe case 210 disposed in the left and right sides, into contact with the left and right of the temporal region of the subject 214.

  As shown in FIG. 30 (a), by arranging 2 × 4 probe holders 211 on the left and right sides of the shell plate 2401, a shell suitable for simultaneously measuring the frontal and occipital regions of the subject 214. A plate 2401 can be constructed. When biological light measurement is performed using the shell plate 2401 shown in FIG. 30A, the probe holder 211 is suspended by supporting the head of the subject 214 sideways as shown in FIG. 30B. Irradiation and detection optical fibers 107 and 108 (not shown), which are the distal end portion of the probe case 210 arranged in the above, can be brought into contact with the front and back heads of the subject 214 at the same time.

  As shown in FIG. 31A, 2 × 2 probe holders 211 are arranged on the left and right sides of the shell plate 2401, respectively, and 2 × 4 probe holders 211 are arranged in the center portion of the shell plate 2401. Thus, a shell plate 2401 suitable for simultaneously measuring the frontal and occipital regions of the subject 214 can be configured. When performing biological light measurement using the shell plate 2401 shown in FIG. 31A, as shown in FIG. 31B, the probe holder 211 is supported by suspending the head of the subject 214 upward. Irradiation and detection optical fibers 107 and 108 (not shown), which are the distal end portion of the probe case 210 arranged in the above, can be brought into contact with the front and back heads of the subject 214 at the same time. However, when the shell plate 2401 shown in FIG. 31A is used, even when the head of the subject 214 is suspended and supported downward, the tip of the probe case 210 disposed in the probe holder 211 is used. Certain irradiation and detection optical fibers 107 and 108 (not shown) can be brought into contact with the front and back of the subject 214 simultaneously.

  As described above, in the measurement probe 101 of the twelfth embodiment, the measurement site can be easily changed by changing the arrangement pattern and the arrangement position of the probe holder 211. Therefore, by preparing a plurality of types of shell plates 2401 in which the arrangement pattern and arrangement position of the probe holder 211 are changed in advance, and appropriately selecting the shell plate 2401 corresponding to the measurement site and the size of the head of the subject 214. The living body light measurement corresponding to various body positions and measurement positions can be performed.

  32 (a) and 32 (b) are diagrams for explaining another configuration example of the measurement probe 101 of the twelfth embodiment. In particular, FIG. 32 (a) shows another shell plate 2401 of the twelfth embodiment. FIG. 32B is a diagram for explaining a schematic configuration of another shell plate 2401 of the twelfth embodiment.

  The measurement probe 101 using the shell plate 2401 of the twelfth embodiment shown in FIG. 32A is similar to the measurement probe 101 of the first embodiment in that the degree of freedom of the shell plate 2401 when the head is suspended and supported. In order to adjust the suspension height, a plurality of holes 2406 are provided in the extending direction of the shell plate 2401.

  A shell plate 2401 shown in FIG. 32 (b) is formed in a shape that removes an unnecessary intersection when the shell plate 2401 is wound around the head of the subject 214 so as to intersect. In this manner, by removing the intersecting portion of the shell plate 2401, it is possible to prevent the shell plate 2401 from being kinked with the intersection. As a result, it is possible to prevent the measurement position from being displaced due to kinking.

  Needless to say, the shell plate 2401 of the twelfth embodiment is formed in a shape that does not reach the eye of the subject 214 so as not to hinder the application of light stimulation or the like. Needless to say, this point must be noted when the subject 214 is set to the measurement probe 101 of the twelfth embodiment.

  In the measurement probe 101 of the twelfth embodiment, the columnar horizontal column 2403 is used. However, the present invention is not limited to this, and the amount of the horizontal column 2403 delivered by using the prismatic horizontal column is not limited thereto. There is an effect that it is possible to prevent the rotation of the column itself at the time of adjustment. In order to prevent rotation of the horizontal column 2403, as another method, a convex portion and / or a concave portion are provided along the extending direction of the horizontal column 2403 formed in a cylindrical shape, and the hole of the horizontal column 2403 is provided in the hole provided with the adjustment column 2402. There is a method of forming a concave portion and / or a convex portion that fits into the convex portion and / or the concave portion. Further, the cross-sectional shape of the horizontal support 2403 is formed in an elliptical shape or a combination of a circle and a straight line, and the shape of the hole provided in the adjustment support 2402 is formed so as to correspond to the shape of the horizontal support 2403. Also good.

  In the twelfth embodiment, the two end portions of the shell plate 2401 are supported at one place, but the present invention is not limited to this. For example, as shown in FIG. A second horizontal column 3101 is provided perpendicular to the horizontal column 2403, and a plurality of hook pins 2405 are arranged in parallel on the second horizontal column 3101 to form a support member. On the other hand, the shell plate 3102 is formed so that the width H of both ends thereof matches the length of the second horizontal column 3101, and there are a plurality of holes 2406 for hooking the respective hook pins 2405 in the width direction of the shell plate 3102. Individually formed. Here, it is possible to improve the stability of the subject 214 in the body axis direction during measurement by hooking each hole 2406 to the respective hook pin 2405. However, the configuration of the shell plate 3102 is the same as that of the shell plate 2401 described above except that the width H of both ends is increased and a plurality of holes 2406 are provided.

  Furthermore, as shown in FIG. 34, it goes without saying that the shell plate 3201 may be hung on the support member of Embodiment 1 without being wrapped around the head of the subject 214.

(Embodiment 13)
FIG. 35 is a diagram for explaining a schematic configuration of the measurement probe 101 in the biological optical measurement apparatus according to the thirteenth embodiment of the present invention. Reference numeral 3301 denotes a shell plate, 3302 denotes a forehead fixing band, 3303 denotes a rear belt, and 3304 denotes The first front belt 3305 is a second front belt 3306 is a body band.

  The measurement probe 101 according to the thirteenth embodiment includes a shell plate 3301, a forehead fixing band 3302 having ends arranged at the top of both ends of the shell plate 3301, and one end fixed to the forehead fixing band 3302. One front belt 3304 and a second front belt 3305, a rear belt 3303 having one end disposed below the shell plate 3301, the first and second front belts 3304 and 3305, and the other end of the rear belt 3303 Is fixed to the body belt 3306.

  As shown in FIG. 35, when the measurement probe 101 according to the thirteenth embodiment is attached, the forehead fixing band 3302 is attached to the forehead of the subject 214, and the body belt 3306 is attached to the chest of the subject 214. At this time, the first and second front belts 3304 and 3305 are arranged so as to intersect at the lower part of the chin of the subject 214, that is, at the throat portion, so that the first when the subject 214 moves the head. And it becomes possible to absorb the looseness of the second front belts 3304 and 3305.

  The measurement probe 101 according to the thirteenth embodiment is a body harness type measurement probe that fixes the other ends of the first and second front belts 3304 and 3305 and the rear belt 3303 to the body belt 3306. Without being limited thereto, as shown in FIG. 36, a chin plate 3401 disposed on the chin of the subject 214 is provided, and two front belts 3402 extending from the forehead fixing belt 3302 are provided on the chin plate 3401. Needless to say, the chin guard type measurement probe 101 may be used to fix the other end of the two and the other ends of the two left and right rear belts 3403 attached to the lower portions of both ends of the shell plate 3301.

  In addition, as shown in FIG. 37, when performing biological light measurement on the left and right temporal regions of the subject 214, the two connecting belts 3502 with the shell plates 3501 arranged on the left and right respectively are arranged on the upper part. Connected. On the other hand, one end of a front belt 3503 and a rear belt 3504 is fixed to the lower part of the shell plate 3501. The other ends of the front belt 3503 and the rear belt 3504 are fixed to body belts 3505 mounted on the chest of the subject 214, respectively. At this time, the front belt 3503 from the left and right shell plates 3501 is arranged so as to intersect under the jaw of the subject 214. Similarly, rear belts 3504 from the left and right shell plates 3501 are arranged so as to intersect at the back portion of the subject 214. In particular, when the shell plate 3501 is disposed on the temporal region, the left and right shell plates 3501 can be prevented from floating from the subject epidermis by crossing the front and rear belts 3503 and 3504, respectively. There is also an effect.

  Further, when the shell plate 3301 is arranged at the back of the subject 214, as shown in FIG. 38, the other end of the rear belt 3601 having one end fixed to the lower portion of the shell plate 3301 is connected to the subject 214. It may be fixed to a body belt 3602 attached to the chest. Also at this time, it is better to cross the rear belt 3601 at the back portion of the subject 214.

(Embodiment 14)
FIG. 39 is a view for explaining a schematic configuration of the hair avoiding jig according to the fourteenth embodiment of the present invention, wherein 3701 is a holding portion, 3702 is a switch, 3703 is a guide, and 3704 is a battery lid.

  As shown in FIG. 39, the hair avoidance jig according to the fourteenth embodiment includes a holding part 3701 and a guide 3703 extending from the holding part 3701.

  The holding unit 3701 incorporates a battery and a light source (not shown), and a switch 3702 is disposed on a side surface of the holding unit 3701. In addition, a battery lid 3704 is disposed on the back surface side of the holding portion 3701, and the battery can be replaced by opening and closing the battery lid 3704.

  The guide 3703 is formed of a well-known transparent resin having a cylindrical or prismatic shape, and one end of the guide 3703 is disposed adjacent to a light source built in the holding portion 3701. Therefore, the light irradiated from the light source passes through the guide 3703 and is irradiated at the other end.

  Further, in the hair avoidance jig according to the fourteenth embodiment, the other end of the guide 3703, that is, the front end is bent. Therefore, even when the hair avoidance work site is parallel to the hair avoidance jig and the hair avoidance jig is used to avoid the hair, the angle at which the tip of the guide 3703 comes into contact with the epidermis can be set. Can be improved.

  A well-known air blower 3801 can be used as a hair avoiding jig. In the hair avoidance using this air blower 3801, as shown in FIG. 40, the compressed air is ejected from the notched portion of the probe holder 211 in the direction indicated by the arrow to avoid the hair at the wind speed.

(Embodiment 15)
FIG. 41 is a view for explaining a schematic configuration of the probe case and the probe holder in the living body optical measurement apparatus according to the fifteenth embodiment of the present invention, in which 3901 indicates a probe case, 3902 indicates an air hose, and 3903 indicates an air outlet. However, in the following description, only the configuration of the probe case 3901, which is different from the configuration of the biological light measurement apparatus of the first embodiment, will be described.

  As shown in FIG. 41, an air outlet 3902 serving as an outlet for compressed air is formed at the tip of the probe case 3901 of the fifteenth embodiment. In addition to the irradiation or detection optical fibers 107 and 108, an air hose 3902 for supplying compressed air to the probe case 3901 is disposed on the other end side of the probe case 3901. The air hose 3902 is connected to a compressor (not shown), and supplies compressed air generated by the compressor to the probe case 3901.

  Accordingly, when the probe case 3901 is attached to the probe holder 211 disposed on the shell plate attached to the head of the subject 214 (not shown), compressed air is ejected in the direction indicated by the arrow. Hair at the tip of the case 3901, that is, at the tip of the optical fiber, is avoided by the wind speed. That is, in the probe case 3901 of the fifteenth embodiment, it is possible to avoid hair without using the above-described jig for avoiding hair, so that the work efficiency of biological light measurement can be improved.

  Since hair avoidance is necessary when the probe case 3901 is attached, the compressor (not shown) may be stopped during measurement and the supply of high-speed air from the air outlet 3903 may be stopped.

(Embodiment 16)
42 (a) and 42 (b) are diagrams for explaining a schematic configuration of the measurement probe 101 in the biological optical measurement device according to the sixteenth embodiment of the present invention. In particular, FIG. 42 (a) shows the sixteenth embodiment. FIG. 42B is a perspective view for explaining the schematic configuration of the probe holder according to the sixteenth embodiment. However, in the following description, only the configurations of the probe case 4001 and the probe holder 4004 that are different from the configuration of the biological light measurement apparatus of the first embodiment will be described.

  42A and 42B, reference numeral 4001 denotes a probe case, 4002 denotes a locking claw, 4003 denotes a release button, 4004 denotes a probe holder, and 4005 denotes a fixing groove.

  As shown in FIG. 42A, the probe case 4001 of the sixteenth embodiment is provided with two locking claws 4002 near the tip of the case body. The locking claw 4002 is interlocked with a release button 4003 disposed behind the probe case 4001. By pushing the release button 4003 in the central axis direction of the probe case 4001, the locking claw 4003 is moved to the probe case 4003. The structure is drawn into 4001. In addition, the locking claw 4003 is formed such that the shape of the portion protruding from the probe case 4001 gradually increases from the tip side to the rear side. The detailed structure of the locking claw 4002 and the release button 4003 will be described later.

  On the other hand, as shown in FIG. 42B, a fixed groove 4005 having a predetermined width is formed along the circumferential direction on the inner peripheral surface of the probe holder 4004, and the probe case 4001 is inserted into the probe holder 4004. In this case, the locking claw 4002 enters the fixing groove 4005 and the probe case 4001 is fixed.

  At this time, in the probe case 4001 of the sixteenth embodiment, an inclination is formed such that the protruding amount of the locking claw 4002 gradually increases from the distal direction, and therefore the release button 4003 is operated when the probe case 4001 is inserted. Since the mounting operation of the probe case 4001 can be performed without mounting, the mounting efficiency can be improved.

  Next, FIG. 43 shows a longitudinal side view of the probe case 4001 of the sixteenth embodiment, and the configuration of the probe case 4001 will be described below based on FIG.

  As shown in FIG. 43, in the probe case 4001, a locking member 4006 having a locking claw 4002 formed at one end and a release button 4003 formed at the other end is disposed. The other end of the spring 4007 whose one end is fixed to the probe case 4001 is fixed to the locking member 4006.

  As described above, in the probe case 4001 of the sixteenth embodiment, the locking claw 4002 and the release button 4003 are integrated, so that the locking claw 4002 is also retracted into the probe case 4001 by pressing the release button 4003. Then, the probe case 4001 is released from the probe holder 4004.

  In the sixteenth embodiment, the locking claw 4002 is provided on the probe case 4001 side. However, the present invention is not limited to this, and the locking claw may be provided on the probe holder 4004 side. Needless to say.

  In the sixteenth embodiment, the rear end portion of the locking claw 4002 is formed so as to be perpendicular to the central axis of the probe case 4001. However, the present invention is not limited to this. For example, the protruding amount gradually decreases. Needless to say, it may be formed as follows. At this time, the probe case 4001 is automatically taken out from the probe holder 4004 when a predetermined force or more is applied to the optical fiber arranged at the tip of the probe case 4001 by adjusting the inclination angle of the locking claw 4002. Therefore, it is possible to prevent the tip portion of the optical fiber from being damaged.

(Embodiment 17)
FIG. 44 is a longitudinal side view of the probe case in the biological optical measurement device according to the seventeenth embodiment of the present invention. Reference numeral 4201 denotes a probe case, 4202 pressure sensor, 4203 denotes a sensor cable, 501a denotes a movable portion, and 501b denotes a spring. However, in the following description, only the configuration of the probe case 4001 that is different from the configuration of the biological light measurement apparatus of the first embodiment will be described.

  In FIG. 44, a pressure sensor 4202 is a known pressure sensor that detects the pressure applied to the spring mechanism 501, and the detection output is output to the information processing apparatus 106 via the sensor cable 4203.

  Next, based on FIG. 44, the structure of the probe case 4201 of Embodiment 17 is demonstrated.

  Similar to the probe case 210 shown in the first embodiment, the probe case 4201 of the seventeenth embodiment includes a spring 501b and a movable portion 501a having one end fixed to the spring 501b on the inner peripheral portion of the probe case 4201. A configured spring mechanism 501 is disposed. Irradiation or detection optical fibers 107 and 108 are fixed to the movable portion 501a.

  On the other hand, the other end of the spring 501b is fixed to the pressure sensor 4202, and this pressure sensor 4202 is fixed to the inner peripheral surface of the probe case 4201.

  One end of a sensor cable 4203 is connected to the pressure sensor 4202, the sensor cable 4203 is pulled out from a cable outlet (not shown) formed in the probe case 4201, and the other end is connected to the information processing apparatus 106. .

  Therefore, in a state where the probe case 4201 is attached to the subject 214 (not shown), the distal end portions of the optical fibers 107 and 108 are applied to the scalp of the subject 214 by the pushing force of the optical fibers 107 and 108 by the spring mechanism 501. It is pressed. That is, when the probe case 4201 is attached to a shell plate (not shown) attached to the subject 214 and the tip portions of the optical fibers 107 and 108 are in contact with the epidermis of the measurement site, the spring 501b is compressed. Will be held.

  As a result, the pressure applied to the pressure sensor 4202 increases, and the detected value is output to the information processing apparatus 106.

  Here, by monitoring the pressure applied to the probe case 4201 by the information processing apparatus 106, it is possible to easily monitor whether or not the tip portions of the optical fibers 107 and 108 are in contact with the surface of the subject 214. Therefore, it is possible to reduce erroneous measurement due to poor mounting of the measurement probe 101. In addition, since the number of re-measurements associated with erroneous measurement can be reduced, the diagnostic efficiency can be improved.

  Furthermore, the information processing device 106 is provided with light intensity correction means for correcting the intensity of light passing through the living body, which is measurement data, based on the measured pressure value, so that the optical fibers 107 and 108 are in contact with the epidermis. Changes in blood flow caused by pushing the epidermis with the optical fibers 107 and 108, and measurement errors due to differences in propagation efficiency of light passing from the epidermis to the optical fibers 107 and 108 are minimized. It becomes possible. It should be noted that the relationship between the pressure and the correction amount is obtained by experiments or the like for each measurement site or the shape of the measurement probe 101.

(Embodiment 18)
FIG. 45 is a perspective view for explaining a schematic configuration of the probe case in the biological optical measurement apparatus according to the eighteenth embodiment of the present invention, and FIG. 46 explains a configuration when the probe case according to the eighteenth embodiment is not attached. FIG. 47 is a longitudinal side view for explaining the configuration when the probe case of Embodiment 18 is mounted. However, in the following description, only the configurations of the probe case 4301 and the probe holder 4308, which are different in configuration from the biological light measurement apparatus of the first embodiment, will be described.

  45 to 47, 4301 is a probe case, 4302 is a guide slit, 4303 is a slide claw, 4304 is a cover, 4305 is a slide member, 4306 is a joint, 4307 is a spring, and 4308 is a probe holder. A probe case 4301 according to the eighteenth embodiment will be described with reference to FIGS.

  As is clear from FIG. 45, the probe case 4301 according to the eighteenth embodiment includes four covers 4304 disposed at the tip of the probe case 4301 and four slide claws 4303 disposed on the outer peripheral surface. A shutter mechanism is provided. The four covers 4304 function as a cover that covers the optical fiber protruding from the tip portion of the probe case 4301. Each cover 4304 is connected to a respective slide claw 4303, and is stored in the probe case 4301 by moving the slide claw 4303. However, the movement of the slide claw 4303 is limited to a guide slit 4302 formed in parallel with the central axis direction of the probe case 4301.

  Next, the shutter mechanism according to Embodiment 18 will be described with reference to FIGS. 46 and 47. FIG.

  As shown in FIG. 46, in the eighteenth embodiment, a slide member 4305 is arranged in the probe case 4301 along the guide slit 4302. A known joint 4306 is attached to one end of the slide member 4305, and a slide claw 4303 is formed at the other end. A cover 4304 is attached to the joint 4306, and the cover 4304 is opened by sliding the slide member 4305 in the direction of the arrow, and is stored in the probe case 4301. However, each joint 4306 is provided with a well-known spring (not shown) for closing the cover 4304.

  A known spring 4307 is arranged on the other end side of the slide member 4305, one end of the spring 4307 is fixed to the slide member 4305, and the other end of a guide slit 4302 formed on the outer periphery of the probe case 4301. It is fixed at the end. Therefore, a force in the direction opposite to the arrow is always applied to the slide member 4305.

  On the other hand, as shown in FIG. 47, a step is formed on the inner peripheral surface of the probe holder 4308 of the eighteenth embodiment. That is, in the probe holder 4308 of the eighteenth embodiment, the inner peripheral diameter on the side arranged on the subject 214 (not shown) is formed to the inner peripheral diameter L1 into which the main body portion of the probe case 4301 can be inserted. The inner diameter on the side far from the inner diameter L2 is formed so that the slide claw 4303 portion can also be inserted.

  Therefore, as shown in FIG. 47, by inserting the probe case 4301 into the probe holder 4308, the slide claw 4303 is slid in the direction of the arrow at the step portion between the inner peripheral diameter L1 and the inner peripheral diameter L2. Therefore, the cover 4304 is opened, and the tip portion of the optical fiber is exposed.

  As described above, the measurement probe 101 according to the eighteenth embodiment is configured such that the cover 4304 of the shutter mechanism is opened and the tip portion of the optical fiber is exposed only when the probe case 4301 is inserted (attached) to the probe holder 4308. Therefore, it is possible to prevent laser light irradiation when not attached. Therefore, the measurement probe 101 main body and the probe case 4301 can be attached and detached without stopping the output of the modulation semiconductor laser 102 (not shown). As a result, it is possible to improve the diagnostic efficiency in biological light measurement.

  In the eighteenth embodiment, the cover 4304 protrudes to the front surface of the optical fiber as the shutter mechanism and the optical fiber is covered with the cover 4304. However, the present invention is not limited to this. Needless to say, the optical fiber may be retracted into 4301 so that the tip of the optical fiber is covered with a cover.

(Embodiment 19)
48 (a) and 48 (b) are diagrams for explaining a schematic configuration of a light shielding mask according to the nineteenth embodiment of the present invention. FIGS. 49 (a) and 49 (b) are measurement probes 101 according to the nineteenth embodiment. It is a figure for demonstrating schematic structure of these. In particular, FIG. 48 (a) is a perspective view of the light shielding mask of the nineteenth embodiment, FIG. 48 (b) is a diagram for explaining the mounting state of the light shielding mask, and FIG. 49 (a) is the embodiment. FIG. 49B is a rear view for explaining the schematic configuration of the measurement probe 101 according to the nineteenth embodiment.

  In FIGS. 48A, 48B and 49A, 49B, 4601 is a light shielding mask, 4602 is a light shielding member, 4603 is a buffer member, 4604 is a fixing member, 4605 is an intake port, and 4701 is a shell plate. Reference numerals 4702 to 4705 denote fixed belts.

  As is clear from FIG. 48 (a), the light shielding mask 4601 of the nineteenth embodiment uses a member that absorbs near infrared light, such as plastic, and the light shielding member is molded into a mortar shape. 4602. In order to reduce the uncomfortable feeling at the time of wearing, for example, a member such as rubber, sponge, or a vinyl leather cushion filled with sponge in the end of the light shielding member 4602 is disposed as a buffer member 4603. Further, the buffer member 4603 prevents a gap from being formed between the light shielding member 4601 and the head of the subject 214 due to the unevenness of the face having a relatively large individual difference.

  Further, a known fixing member 4604 for fixing the light shielding mask 4601 to the head of the subject 214 is disposed at the end of the light shielding member 4602. The fixing member 4604 according to the nineteenth embodiment is formed of a well-known band having stretchability that is stretched over a position where the end of the light shielding member 4602 faces. It goes without saying that the fixing member 4604 needs to be attached at a position that does not cover the measurement site. Therefore, a known slide mechanism that can move the mounting position of the fixing member 4604 up and down may be provided at the end of the light shielding member. Alternatively, a plurality of types of light shielding masks 4601 with different mounting positions may be prepared, and may be selected as needed according to the measurement site.

  A plurality of holes are formed as air inlets 4605 on the surface of the light shielding member 4602. As shown in FIG. 48B, the formation position of the intake port 4605 is formed to be the same position as the mouth of the subject 214 when worn. As a result, the load on the subject 214 is reduced.

  As is apparent from FIG. 48B, the mounting position of the light shielding mask 4601 of the nineteenth embodiment is the head of the subject 214, and the probe case (not shown) is mounted by mounting the light shielding member 4602 so as to cover the face. It is possible to prevent the near-infrared light from being directly irradiated to the face during the desorption.

  Next, the configuration of the measurement probe 101 of the nineteenth embodiment for temporal measurement will be described with reference to FIGS.

  As is apparent from FIGS. 49A and 49B, the measurement probe 101 according to the nineteenth embodiment has two shell plates 4701 on which probe holders (not shown) are arranged and a shell plate 4701 attached to the subject 214. The first to fourth fixing belts 4702, 4703, 4704, and 4705 are configured. A probe holder (not shown) is arranged at a predetermined position of each shell plate 4701.

  The first belt 4702 is disposed on the top of the head, the second belt 4703 is disposed on the chin, the third belt 4704 is disposed on the back of the head, and the fourth belt 4705 is disposed on the face side. At this time, in the nineteenth embodiment, as shown in FIG. 49A, when the measurement probe 101 is attached to the subject 214 to which the light shielding mask 4601 is attached, that is, on the light shielding mask 4601, the fourth. Therefore, the length is set in consideration of the light shielding member 4602.

  As is clear from FIG. 49B, since the fixing member 4604 does not come into contact with the shell plate 4701 even when the light shielding mask 4701 and the measurement probe 101 are mounted, the biological light at a desired measurement position is obtained. Measurement can be performed.

  The light shielding mask 4601 according to the nineteenth embodiment is configured to cover only the face of the subject 214, but is not limited to this. For example, the shell plates 2201 and 2204 according to the tenth embodiment are not limited to this. Needless to say, the light shielding member 4602 may be disposed on the face portion. Furthermore, a shell plate in which a light shielding member 4602 is disposed on the face portion of a shell plate that covers only the head of the subject 214 and a probe holder is disposed on the occipital region, the temporal region, or the like, as if it is a fencing face mask. Needless to say.

  In addition, since the size of the head has a relatively large individual difference, a plurality of types of light-shielding masks 4601 are prepared in advance, and the most suitable one according to the shape of the head of the subject 214 is selected and used. It is possible to prevent a gap from being generated between the mask 4601 and the head.

  50A and 50B, the other end of the fixing member 4801 to 4805 for fixing the light shielding mask 4601 to the subject 214 is fixed to the shell plate. That is, the light shielding mask 4601 and the measurement probe 101 are fixed. Since the light shielding mask 4601 and the measurement probe 101 can be attached at the same time, the diagnostic efficiency can be improved. Furthermore, by integrally forming the light shielding mask 4601 and the measurement probe 101, there is an effect that the contact between the shell plate 4801 and the fixing members 4802 to 4805 at the time of mounting can be prevented.

(Embodiment 20)
FIG. 51 is a diagram for explaining a schematic configuration of the stimulation device in the biological light measurement device according to the twentieth embodiment of the present invention. 4901 is a display support portion, 4902 is a support column, 4903 is a height adjustment screw, and 4904 is a display. Indicates the device. However, in the following description, only the configuration of the stimulation device having a configuration different from that of the biological light measurement device of the first embodiment will be described as in the fourth embodiment. X, Y, and Z represent the X axis, the Y axis, and the Z axis, respectively.

  As is clear from FIG. 51, the stimulating device of the twentieth embodiment is a flat display support portion 4901 in which a display device 4904 is disposed at the center portion, and the display support portions 4901 disposed at the four corners of the display support portion 4901. Four columns 4902 for holding 4901 at a predetermined height, four height adjusting screws 4903 disposed on the side surface of the display support member 4901, and a display device 4904 disposed at the center portion of the display support portion 4901. It consists of.

  The display device 4904 includes, for example, a well-known liquid crystal display device (not shown) and a well-known speaker (not shown) arranged on the same side as the display surface of the liquid crystal display device, as in the fourth embodiment.

  The display support portion 4901 has an opening at the center, and a display device 4904 is disposed in the opening. In addition, holes penetrating in the Z-axis direction are formed at the four corners of the display support portion 4901, and a column 4902 is passed through each hole. The length of at least one of the display support 4901 in the X-axis direction or the Y-axis direction is greater than the head width of the subject 214 to be measured.

  The height adjustment screw 4903 is disposed on the side surface of the display support portion 4901, that is, a surface parallel to the Z axis. The height adjustment screw 4903 is formed to have a length that protrudes from the inner peripheral surface of a hole formed at the four corners of the display support portion 4901.

  Therefore, in the stimulation apparatus of the twentieth embodiment, the distance from the subject 214 to the display surface of the display device 4904 can be arbitrarily set by adjusting the position where the display support 4901 is fixed with the height adjustment screw 4903. Can do. As a result, it is possible to perform measurement on all subjects 214 having different head sizes such as adults and children. Furthermore, the height can be adjusted when relaxation is applied when a strong stimulus is applied or when the subject 214 cannot concentrate on one point.

  Furthermore, since the stimulation device of the twentieth embodiment can independently adjust the heights of the four columns 4902, for example, the installation location of the stimulation device is uneven or the installation location. There is also an effect that it can be installed in parallel with the subject 214 even when is tilted.

  As described above, since the stimulation apparatus according to the twentieth embodiment can arbitrarily set the position of the display device 4904, the display device can be installed at an optimal position in accordance with the line-of-sight position of the subject. That is, by moving the stimulating device in the body axis direction, it is possible to select measurement with the eye line facing downward, measurement with the eye line facing the front, or measurement with the eye line facing upward as necessary. . Therefore, it is possible to easily perform biological light measurement with the eye line facing down, which is suitable for light stimulation to an infant whose eye line is difficult to face up.

  In the twentieth embodiment, a liquid crystal display device is used for the display device 4904 that is a means for generating light stimulation. However, the present invention is not limited to this. For example, a well-known light bulb, strobe device, projector device, It goes without saying that a backlight device or the like used for a liquid crystal display device may be used. As in the fourth embodiment, when performing biological light measurement using an infant as the subject 214, it is difficult to gaze at the display device 4904. Therefore, a light bulb or strobe device capable of relatively high-capacity light emission. Or a projector apparatus is suitable.

  In addition, multiple types of devices such as light bulbs, strobe devices, projector devices, and backlight devices are prepared in advance to perform simple light stimulation such as blinking light and complex light stimulation such as patterns. By appropriately selecting the type of the device to be arranged on the display support portion 4901 for the measurement to be given, it is possible to give the optimal light stimulus to the subject 214, so that the measurement accuracy can be improved.

  Further, as shown in FIG. 52, an incubator 5001 in which a fixing mechanism 5002 is provided on the upper surface of a known incubator and a display device 4904 is arranged on the fixing mechanism 5002 is considered as a stimulator suitable for an infant. It is done. In the stimulation apparatus shown in FIG. 52, since the subject 214 is set in the incubator 5001, the movement in the body axis direction is restricted. Therefore, it is possible to easily perform biological light measurement with the eye line facing down, which is suitable for light stimulation to an infant whose eye line is difficult to face up.

  In the stimulation apparatus shown in FIG. 52, a well-known slide mechanism is provided in the fixing device 5002, and the slide direction is the body axis direction of the subject 214, that is, the longitudinal direction of the incubator 5001, so The stimulus can be given to the subject 214 under optimum conditions.

(Embodiment 21)
FIG. 53 is a diagram for illustrating a schematic configuration of the biological light measurement device according to the twenty-first embodiment of the present invention. Reference numeral 5101 denotes a video camera, and 5102 denotes a control synthesis unit. However, in the following description, only the video camera 5101 and the control synthesis unit 5102 that are different in configuration from the biological light measurement devices of Embodiments 1 and 4 will be described.

  In FIG. 53, a video camera 5101 is a well-known video camera that captures and records the state of a subject 214 (not shown). In the twenty-first embodiment, in particular, the front surface of the subject 214, that is, the side on which the stimulating device 1301 is disposed. Set to shoot.

  Based on the measurement start from the information processing apparatus 106, the control synthesis unit 5102 instructs the video camera 5101 to start and end recording of the subject 214, and outputs the elapsed time from the recording start to the information processing apparatus 106. In addition, the control synthesis unit 5102 outputs an image at a specified time to the information processing device 106 based on a reproduction instruction from the information processing device 106. This reproduced image is displayed on a display screen of a display device (not shown) connected to the image processing device 106.

  Next, FIG. 54 shows a display example by the biological light measurement device of the twenty-first embodiment. Hereinafter, the operation of the biological light measurement device of the twenty-first embodiment will be described based on FIG.

  54, reference numeral 5201 denotes a display screen, reference numeral 5202 denotes a display area of a reproduction image, and reference numerals 5203 to 5208 denote display areas of measurement results.

  The recorded state of the subject 214 is reproduced and displayed in the display area 5202 of the reproduced image, and the measurement data obtained at that time is displayed in the display areas 5203 to 5208 of the measurement results.

  As described above, the living body light measurement apparatus according to the twenty-first embodiment can always measure the state (state) of the subject 214 at the time of living body light measurement. In analyzing the result, it can be confirmed whether the subject 214 is interested in the stimulus, that is, whether the subject is conscious of the stimulus. As a result, since the analysis can be performed only from the measurement result when the subject 214 is conscious of the stimulus, the accurate analysis can be performed. Accordingly, it is not necessary to perform re-measurement or the same measurement a plurality of times, so that diagnostic efficiency (measurement efficiency) can be improved.

(Embodiment 22)
FIGS. 55A and 55B are views for explaining a schematic configuration of the measurement probe 101 in the biological light measurement apparatus according to the twenty-second embodiment of the present invention. FIGS. It is a figure for demonstrating the mounting state of the measurement probe 101 of the form 22. FIG. In particular, FIG. 55 (a) is a diagram for explaining the schematic configuration of the shell plate, FIG. 55 (b) is a diagram for explaining the schematic configuration of the air balloon, and FIG. 56 (a) is a measurement probe. It is a figure for demonstrating the state immediately after mounting | wearing of 101, FIG.56 (b) is a figure for demonstrating the state which put air into the air balloon. However, in the following description, only the configuration related to the present embodiment 22 in the measurement probe 101, which is different from the configuration of the biological light measurement apparatus of the first embodiment, will be described.

  As shown in FIG. 55A, the shell plate 5301 of the twenty-second embodiment has the same configuration as the above-described shell plate. A belt 5305 (not shown) is disposed at the end of the shell plate, and the shell plate 5301 is fixed to the subject 214 with the belt 5305. However, for simplicity of explanation, the probe holder is omitted, and only the hole 5302 in which the probe holder is disposed is shown.

  The air balloon 5303 is formed of a resin having flexibility such as a well-known floating ring, for example, and a position corresponding to the hole 5302 provided in the shell plate 5301 as shown in FIG. An opening 5304 is formed in the opening. The air balloon 5303 is formed with an air port (not shown), and expands to a predetermined volume by introducing air from the air port.

  Next, the mounting procedure and effects of the measurement probe 101 according to the twenty-second embodiment will be described with reference to FIGS.

  As shown in FIG. 56A, the head of the subject 214 has various shapes depending on individual differences. In the shell plate 5301 prepared in advance, a gap 5306 is provided between the shell plate 5301 and the head. May occur. That is, since the contact area between the shell plate 5301 and the head is reduced, the shell plate 5301 is likely to be displaced.

  Therefore, as shown in FIG. 56 (b), the air balloon 5303 is disposed between the shell plate 5301 and the head, and the air balloon 5303 causes the gap 5306 between the shell plate 5301 and the head to enter. Since the measurement probe 101 is in close contact with the subject 214, it is possible to prevent the measurement probe 101 from being displaced. As a result, the accuracy of biological light measurement can be improved. In addition, since the displacement of the measurement probe 101 can be prevented, it is possible to reduce the re-measurement due to the displacement and improve the diagnostic efficiency.

  However, a chin plate 5307 is disposed on the belt 5305 provided on the shell plate 5301 of the twenty-second embodiment, and the chin plate 5307 is applied to the chin portion of the subject 214. That is, since the belt 5305 regulates the movement of the shell plate 5301 due to the expansion of the air balloon 5303, the measurement probe 101 can be in close contact with the subject 214.

(Embodiment 23)
57 (a), (b), and (c) are diagrams for explaining a schematic configuration of the measurement probe 101 in the biological light measurement device according to the twenty-third embodiment. In particular, FIG. 57 (a) shows a shell plate. FIG. 57B is a vertical side view of the shell plate, and FIG. 57C is a view for explaining the mounting state of the measurement probe 101. FIG. However, in the following description, only the configuration of the shell plate according to the twenty-third embodiment in the measurement probe 101, which is different from the configuration of the biological light measurement apparatus of the first embodiment, will be described.

  As is clear from FIG. 57 (a), the shell plate 5501 of the twenty-third embodiment has an air passage 5503 for guiding air in the vicinity of a hole 5502 in which a probe holder (not shown) is arranged. Accordingly, one end of the air passage 5503 is gathered into one place and connected to the air hose 5504. On the other hand, the other end of the air passage 5503 is opened on the subject side of the shell plate 5501. Air hose 5504 is supplied with compressed air.

  Therefore, as shown in FIGS. 57 (b) and 57 (c), the compressed air supplied through the air passage 5503 is attached to the probe holder serving as the opening, that is, the optical fibers 107 and 108 (not shown). Since it is ejected to the position where the end portion is arranged as shown by the arrow, the hair is moved by the ejected compressed air, and the background is exposed at the ejection location. That is, it is not necessary to avoid hair associated with the mounting of a probe case (not shown), so that the mounting of the measurement probe is facilitated. As a result, diagnostic efficiency can be improved. Furthermore, since only compressed air is ejected, hair can be avoided without damaging the scalp of the subject 214. However, the position and angle of the opening where the compressed air is ejected are measured in advance by the probe case and shell plate used, and the optimum position and angle are determined.

  In the embodiment of the present invention, the semiconductor laser is used as the light source. However, the present invention is not limited to this. For example, a titanium sapphire laser or a light emitting diode may be used as the light source. Absent.

  In addition, the living body passage light intensity image which is display image data obtained by the cubic spline interpolation calculation is not only displayed on the display device, but also, for example, a magnetic disk which is an external storage device (not shown) connected to the information processing device 106 Needless to say, the data may be stored in a device or an optical disk device.

  Needless to say, a three-dimensional image measured by an X-ray CT apparatus or MR apparatus may be displayed by superimposing a biological light intensity image stored in an external storage device.

  Furthermore, in the measurement probe 101 of the present embodiment, the case where the longitudinal direction of the pillow base 208, that is, the length in the suspension direction of the belt 202 is fixed has been described, but the structure of the pillow base 208 is limited to this. For example, as shown in FIG. 58A, a known rail mechanism is provided in which a longitudinal portion of the pillow base 208 is divided into two and a rail 5601 is disposed therebetween, and the divided pillow base 208 is divided. By providing a well-known fixing mechanism for fixing the rail 5601 to the rail 5601 with the screw 5602, it is possible to adjust the interval between the support columns 205, so that the measurement most suitable for the size of the head of the subject 214 is performed. Is possible. FIG. 58 (b) is a longitudinal side view of the rail mechanism portion, and as is apparent from FIG. 58 (b), the pillow base 208 is formed in a U-shape. A rail 5601 is passed through the space, and the rail 5601 is fixed to the pillow base 208 with a screw 5602 to adjust the interval between the support columns 205 to a predetermined interval.

  As mentioned above, the invention made by the inventors has been specifically described based on the embodiment of the invention, but the invention is not limited to the embodiment of the invention and does not depart from the gist of the invention. Of course, various changes in the range are possible.

The effects obtained by the representative ones of the inventions disclosed in the present application will be briefly described as follows.
(1) Biological light measurement in the recumbent position can be performed.
(2) It is possible to easily avoid hair when the measurement probe is mounted.
(3) Biological light measurement can be performed while applying a predetermined stimulus to the subject.
(4) The diagnostic efficiency can be improved.

It is a figure for demonstrating schematic structure of the biological light measuring device of Embodiment 1 of this invention. It is a front view for demonstrating schematic structure of the measurement probe of Embodiment 1 of this invention. It is a top view for demonstrating schematic structure of the measurement probe of Embodiment 1 of this invention. It is a side view for demonstrating schematic structure of the measurement probe of Embodiment 1 of this invention. It is a vertical side view for demonstrating schematic structure of the probe holder and probe case of Embodiment 1 of this invention. (A), (b), (c) It is a figure for demonstrating the relationship between the shell plate of Embodiment 1 of this invention, and a silicone rubber sheet. (A), (b), (c) It is a figure for demonstrating schematic structure of the other silicon rubber sheet of Embodiment 1 of this invention. It is a front view for demonstrating schematic structure of the measurement probe in the biological light measuring device of Embodiment 2 of this invention. It is a top view for demonstrating schematic structure of the measurement probe in the biological light measuring device of Embodiment 2 of this invention. It is a side view for demonstrating schematic structure of the measurement probe in the biological light measuring device of Embodiment 2 of this invention. (A), (b) It is a figure for demonstrating schematic structure of the probe holder and probe case of Embodiment 2 of this invention. It is a vertical side view for demonstrating schematic structure of the measurement probe in the biological light measuring device of Embodiment 3 of this invention. It is a top view for demonstrating schematic structure of the measurement probe in the biological light measuring device of Embodiment 3 of this invention. It is a side view for demonstrating schematic structure of the measurement probe in the biological light measuring device of Embodiment 3 of this invention. It is a figure for demonstrating schematic structure of the other measurement probe in the biological light measuring device of Embodiment 3 of this invention. It is a figure for demonstrating schematic structure of the biological light measuring device of Embodiment 4 of this invention. It is a figure for demonstrating schematic structure of the irritation | stimulation apparatus in the biological light measuring device of Embodiment 4 of this invention. It is a figure for demonstrating operation | movement when using together the measurement probe and stimulation apparatus of Embodiment 1, 2 of this invention. It is a figure for demonstrating schematic structure of the measurement probe in the biological light measuring device of Embodiment 5 of this invention. It is a figure for demonstrating schematic structure of the measurement probe in the biological light measuring device of Embodiment 6 of this invention. (A), (b) It is a figure for demonstrating schematic structure of the probe case used with the measurement probe in the biological light measuring device of Embodiment 7 of this invention. (A), (b) It is a figure for demonstrating schematic structure of the measurement probe in the biological light measuring device of Embodiment 8 of this invention. (A), (b) It is a figure for demonstrating schematic structure of the measurement probe in the biological light measuring device of Embodiment 9 of this invention. (A), (b) It is a figure for demonstrating schematic structure of the measurement probe in the biological light measuring device of Embodiment 10 of this invention. It is a figure for demonstrating schematic structure of the measurement probe in the biological light measuring device of Embodiment 11 of this invention. It is a figure for demonstrating schematic structure of the measurement probe in the biological light measuring device of Embodiment 12 of this invention. (A), (b) It is a figure for demonstrating the detailed structure of the shell plate of Embodiment 12 of this invention. (A), (b) It is a figure for demonstrating the relationship between the biological-light measurement position and probe holder position of Embodiment 12 of this invention. (A), (b) It is a figure for demonstrating the relationship between the biological-light measurement position and probe holder position of Embodiment 12 of this invention. (A), (b) It is a figure for demonstrating the relationship between the biological-light measurement position and probe holder position of Embodiment 12 of this invention. (A), (b) It is a figure for demonstrating the relationship between the biological-light measurement position and probe holder position of Embodiment 12 of this invention. (A), (b) It is a figure for demonstrating the structural example of the other shell plate used for the other measurement probe of Embodiment 12 of this invention. It is a figure for demonstrating the structural example of the other shell plate used for the other measurement probe of Embodiment 12 of this invention. It is a figure for demonstrating the structural example of the other shell plate used for the other measurement probe of Embodiment 12 of this invention. It is a figure for demonstrating schematic structure of the measurement probe in the biological light measuring device of Embodiment 13 of this invention. It is a figure for demonstrating schematic structure of the other measurement probe in the biological light measuring device of Embodiment 13 of this invention. It is a figure for demonstrating schematic structure of the other measurement probe in the biological light measuring device of Embodiment 13 of this invention. It is a figure for demonstrating schematic structure of the other measurement probe in the biological light measuring device of Embodiment 13 of this invention. It is a figure for demonstrating schematic structure of the hair avoidance jig | tool of Embodiment 14 of this invention. It is a figure for demonstrating schematic structure of the other hair avoidance jig | tool of Embodiment 14 of this invention. It is a figure for demonstrating schematic structure of the probe case in the biological light measuring device of Embodiment 15 of this invention. (A), (b) It is a figure for demonstrating schematic structure of the probe case and probe holder used for the measurement probe in the biological light measuring device of Embodiment 16 of this invention. It is a vertical side view of the probe case of Embodiment 16 of this invention. It is a vertical side view of the probe case used for the measurement probe in the biological light measurement device of Embodiment 17 of the present invention. It is a perspective view for demonstrating schematic structure of the probe case used for the measurement probe in the biological light measuring device of Embodiment 18 of this invention. It is a vertical side view for demonstrating the structure when the probe case of Embodiment 18 of this invention is not mounted | worn. It is a vertical side view for demonstrating the structure at the time of mounting | wearing with the probe case of Embodiment 18 of this invention. (A), (b) It is a figure for demonstrating schematic structure of the light shielding mask used with the measurement probe of the biological light measuring device of Embodiment 19 of this invention. (A), (b) It is a figure for demonstrating schematic structure of the measurement probe used with the light-shielding mask of Embodiment 19 of this invention. (A), (b) It is a figure for demonstrating schematic structure of the other measurement probe used with the light-shielding mask of Embodiment 19 of this invention. It is a figure for demonstrating schematic structure of the stimulating device in the biological light measuring device of Embodiment 20 of this invention. It is a figure for demonstrating schematic structure of the other stimulating device in the biological light measuring device of Embodiment 20 of this invention. It is a figure for demonstrating schematic structure of the biological light measuring device of Embodiment 21 of this invention. FIG. 38 shows a display example of the biological light measurement device according to the twenty-first embodiment. (A), (b) It is a figure for demonstrating schematic structure of the measurement probe in the biological light measuring device of Embodiment 22 of this invention. (A), (b) It is a figure for demonstrating the mounting state of the measurement probe of Embodiment 22 of this invention. (A), (b), (c) It is a figure for demonstrating schematic structure of the measurement probe in the biological light measuring device of Embodiment 23 of this invention. (A), (b) It is a figure for demonstrating schematic structure of the other supporting member used with the measurement probe of this invention.

Claims (8)

A measurement probe that irradiates a subject with light having a plurality of wavelengths guided by an optical fiber from a light source, and collects light that has passed through the subject from a plurality of parts, and the living body of the subject from the collected passing light In the biological light measurement device that generates a passing light intensity image,
The measurement probe includes a cylindrical probe case that holds the optical fiber, an optical fiber fixing member that fixes the probe case at a predetermined interval, and a support member that supports the optical fiber fixing member. One of the case and the optical fiber fixing member is provided with a locking claw that enables engagement between the cylindrical probe case and the optical fiber fixing member. . 2. The biological light measurement device according to claim 1, wherein a fixing groove having a predetermined width is formed along the circumferential direction on an inner peripheral surface of each of the optical fiber fixing members or an outer peripheral surface of the probe case. . The living body optical measurement device according to claim 2, wherein the locking claw is provided in the vicinity of the tip of the probe case so as to be able to engage with the fixing groove. 4. The living body according to claim 3, wherein the shape of the locking claw protruding toward the optical fiber fixing member is formed such that the protruding amount gradually increases from the front end toward the rear end. Optical measuring device. The living body optical measurement device according to claim 1, wherein the optical fiber fixing member is provided with a locking claw for appropriately positioning the probe case. The living body light measuring apparatus according to claim 1, wherein a spring mechanism is incorporated in an inner peripheral portion of the probe case, and a movable side of the spring mechanism is fixed to an optical fiber. A release button is formed integrally with the locking claw, and when the release button is pushed, the locking claw is retracted into the probe case, and the probe case is released from the optical fiber fixing member. The living body light measuring device according to claim 1 characterized by things. The living body light measuring apparatus according to claim 1, wherein a guide slit is provided in the probe case, and a slide member is disposed along the guide slit.

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