JP2006340845A - Blood circuit - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To provide a blood circuit capable of reducing residual blood by eliminating the difference in level for detecting the negative pressure, and capable of retaining the workability in the dialytic therapy, etc. <P>SOLUTION: The blood circuit comprises a blood purifier 7, an artery-side blood circuit L1 for making the blood collected by a puncture needle at the distal end flow into the blood purifier 7, a vein-side blood circuit L2 for making the blood from the blood purifier 7 flow to the puncture needle at the distal end to be returned into the body of a patient, and a liquid introduction line L3 for introducing the liquid into the artery-side blood circuit L1. In the blood circuit, part of the liquid introduction line L3 is disposed parallel to the artery-side blood circuit L1, and the parallel part of the liquid introduction line L3 is integrated with the artery-side blood circuit L1. A part constituting the integrated part of the artery-side blood circuit L1 is made softer than a part constituting the liquid introduction line L3 so that the artery-side blood circuit L1 can be bent in the radial direction with the negative pressure inside the artery-side blood circuit. <P>COPYRIGHT: (C)2007,JPO&INPIT

Description

  The present invention relates to a blood circuit for collecting blood from a patient and purifying it with a blood purifier such as a dialyzer in the course of extracorporeal circulation, and then returning the purified blood to the patient again, in particular, a liquid such as physiological saline. The present invention relates to a blood circuit provided with a liquid introduction line for introducing a liquid into a blood flow path.

  As shown in FIG. 9, a general blood circuit used at the time of dialysis treatment is an arterial blood circuit L1 having an arterial puncture needle 101 attached to one end and a venous blood circuit having a venous puncture needle 102 attached to one end. L2 is configured mainly, and a dialyzer 104 serving as a blood purifier can be connected to the other ends of the arterial blood circuit L1 and the venous blood circuit L2.

  The arterial blood circuit L1 is provided with an iron-type blood pump 103. By driving the blood pump 103 with both the arterial puncture needle 101 and the venous puncture needle 102 punctured in the patient, Blood is collected from the arterial puncture needle 101, and the blood flows in the arterial blood circuit L1 to the dialyzer 104. The blood purified by the dialyzer 104 flows in the venous blood circuit L2, and the vein Dialysis treatment is performed by returning to the patient's body through the side puncture needle 102.

  An arterial drip chamber 106 and a venous drip chamber 107 are connected to the arterial blood circuit L1 and the venous blood circuit L2, respectively, and upstream of the blood pump 103 in the arterial blood circuit L1. Is connected to a negative pressure detecting member 105 for detecting the negative pressure. As shown in FIG. 10, the negative pressure detecting member 105 is formed of a flexible hollow member having a predetermined capacity space 105a therein, and a surface portion when blood flowing in the artery-side blood circuit L1 becomes negative pressure. The negative pressure can be detected by, for example, bringing a probe of a negative pressure detector into contact with the front surface portion and the back surface portion.

  Furthermore, in order to introduce physiological saline into the blood circuit to perform priming, replacement fluid or blood collection, a saline line (fluid introduction line) L3 extending from the container C filled with physiological saline is formed as shown in FIG. Has been. Conventionally, the saline line L3 is disposed in parallel with the arterial blood circuit L1 via the T-shaped tube 108 while extending in a direction close to the arterial blood circuit L1 from the container C, and has a Y-shaped tube 109 at the tip. And connected to the vicinity of the artery side puncture needle 101.

  Thereby, the physiological saline in the container C is guided to the vicinity of the arterial puncture needle 101 in the arterial blood circuit L1 via the saline line L3, and the physiological saline is supplied to the arterial blood circuit L1, the dialyzer 104, and the venous blood circuit. It can be flowed into the blood flow path in L2, and priming, replacement fluid or blood recovery with the physiological saline is performed. Of course, during normal dialysis treatment, the flow path of the saline line L3 is blocked by a clamping device (not shown) or the like. In addition, since this prior art does not relate to the literature known invention, there is no prior art document information to be described.

  However, the conventional blood circuit has the following problems. That is, since the negative pressure detecting member 105 connected to the arterial blood circuit L1 has a space 105a into which blood is introduced, blood tends to stay in the corner (the hatched portion in FIG. 10). In addition, even when physiological saline is supplied from the raw food line L3 and blood is collected, there is a possibility that blood remains attached to the corner and residual blood is generated.

  As a result of study for improvement in order to solve the above-mentioned problems, the present applicant has made the flexible tube constituting the arterial blood circuit L1 thinner to make it softer, and the blood flowing inside is negatively affected. It was considered to bend in the radial direction when the pressure was reached. As a result, the step of the blood flow path such as the corner of the space 105a can be eliminated, the retention of blood can be suppressed, and the negative pressure can be detected by detecting the deflection in the radial direction. Can do.

  However, if the flexible tube constituting the arterial blood circuit L1 is soft as described above, it is naturally easy to bend, and it is expected that a new problem will occur that the flow path may be blocked by the bend. The Therefore, the blood circuit must be handled very carefully so as not to inadvertently block the flow path, and workability such as dialysis treatment or priming may be deteriorated.

  The present invention has been made in view of such circumstances, and provides a blood circuit capable of suppressing residual blood by eliminating a step for detecting negative pressure and maintaining workability during dialysis treatment and the like. There is to do.

  The invention according to claim 1 is connected to the blood purifier and is connected to the blood purifier and an arterial blood circuit for flowing the blood collected from the puncture needle at the tip to the blood purifier. In the blood circuit having a venous blood circuit for flowing the blood of the blood to the puncture needle at the tip and returning it to the patient's body, and a liquid introduction line for introducing liquid into the arterial blood circuit or the venous blood circuit, At least a part of the liquid introduction line is disposed in parallel with the arterial blood circuit or the venous blood circuit, and the liquid introduction line and the arterial blood circuit or the venous blood circuit in the parallel part are integrated. In addition, the part constituting the arterial blood circuit or the vein side blood circuit in the integrated part is formed softer than the part constituting the liquid introduction line, and the arterial blood circuit or static Characterized in that to obtain flexing radially negative pressure in the side blood circuit.

  According to a second aspect of the present invention, in the blood circuit according to the first aspect, a part of the liquid introduction line is disposed in parallel with the arterial blood circuit or the venous blood circuit, and a tip is the puncture It extends to the vicinity of the needle and is connected to the arterial blood circuit or the venous blood circuit, and comprises a saline line through which physiological saline can be introduced from the vicinity of the puncture needle.

  The invention according to claim 3 is the blood circuit according to claim 1 or 2, wherein the integrated part is composed of a single flexible tube having two flow holes extending in the axial direction. These flow holes are formed at positions deviated from the axis of the flexible tube, and one flow hole is used as a part of the arterial blood circuit or the venous blood circuit, and the other flow hole is formed in the liquid introduction line. It is characterized by being part.

  The invention according to claim 4 is the blood circuit according to claim 3, characterized in that one of the flow holes in the flexible tube has an elliptical cross-sectional shape.

  According to a fifth aspect of the present invention, in the blood circuit according to the first or second aspect, the integrated portion is formed by joining two flexible tubes each having a flow hole extending in the axial direction. One flow hole is a part of the arterial blood circuit or the venous blood circuit, and the other flow hole is a part of the liquid introduction line.

  According to the first aspect of the present invention, the fluid introduction line and the arterial blood circuit or the venous blood circuit are integrated in a part extending in parallel, and the arterial blood circuit or the venous blood circuit in the integrated part is configured. Since the portion to be made is softer by making the wall thickness thinner than the portion constituting the liquid introduction line, the negative pressure in the artery side blood circuit or the vein side blood circuit can be bent in the radial direction. The step for pressure detection can be eliminated to suppress residual blood and bend easily to maintain workability during dialysis treatment.

  According to the invention of claim 2, since the liquid introduction line is composed of a saline line, the saline line arranged in parallel with the arterial blood circuit or the venous blood circuit is used as a reinforcing member as it is. The effect of the invention of claim 1 can be fully exhibited.

  According to the invention of claim 3, since the integrated part is composed of one flexible tube having two flow holes extending in the axial direction, the arterial blood circuit or the venous blood circuit The part in parallel with the liquid introduction line can be integrally formed, and the manufacturing cost can be reduced.

  According to the invention of claim 4, since one of the flow holes in the flexible tube has an elliptical cross-sectional shape, the area of the thin portion that is a part for detecting negative pressure can be increased. Negative pressure can be easily detected.

  According to the invention of claim 5, since the integrated portion is formed by joining two flexible tubes each having a flow hole extending in the axial direction, an existing flexible tube ( The effect of the invention of claim 1 can be obtained by using a thick wall).

Hereinafter, embodiments of the present invention will be specifically described with reference to the drawings.
The blood circuit according to the embodiment of the present invention comprises a flexible tube for circulating a patient's blood extracorporeally during dialysis treatment, and is connected to a dialyzer 7 as a blood purifier as shown in FIG. It is mainly composed of an arterial blood circuit L1 and a venous blood circuit L2. Note that each of the tubes constituting the arterial blood circuit L1 and the venous blood circuit L2 is a flexible tube made of soft vinyl chloride.

  The arterial blood circuit L1 includes an integrated flexible tube 3, flexible tubes a to c and g, and a large-diameter flexible tube 4a. The arterial blood circuit L1 is composed of a line upstream from the dialyzer 7 and has a distal end. It is connected to the arterial puncture needle 1 via the connector 1a. Both ends of the integrated flexible tube 3 are connected to the flexible tubes a and g via the first connecting tube 8 and the second connecting tube 9, and between the flexible tubes b and c. A drip chamber (arterial drip chamber) 5 is connected.

  The large-diameter flexible tube 4a is provided with a blood pump 4 composed of a peristaltic pump, and is configured so that the patient's blood collected by the arterial puncture needle 1 can be fed to the dialyzer 7 side. The first connecting pipe 8 is connected to a flexible tube f that constitutes a part of the saline line L3 as a liquid introduction line extending from the container C filled with physiological saline. Can be introduced into the arterial blood circuit L1.

  The flexible tube c located at the downstream end of the arterial blood circuit L1 is connected to the blood introduction port 7a in the dialyzer 7. The blood introduced into the dialyzer 7 passes through the inside hollow fiber membrane (blood flow path) and is discharged from the blood discharge port 7b, while the dialysate introduced from the dialysate introduction port 7c becomes the hollow fiber membrane. It passes through the outside (dialysate flow path) and is discharged from the dialysate discharge port 7d.

  As a result, wastes and the like in the blood passing through the blood flow path can be permeated to the dialysate side to be purified, and the clean blood can be returned to the patient's body via the venous blood circuit L2. it can. The venous blood circuit L2 is composed of flexible tubes d and e, and is composed of a line on the downstream side of the dialyzer 7. The distal end of the venous blood circuit L2 is connected to the venous puncture needle 2 via a connector 2a. A drip chamber (venous drip chamber) 6 is connected between the flexible tubes d and e.

  The above is the overall configuration of the blood circuit applied to this embodiment. Here, the integrated flexible tube 3 in the arterial blood circuit L1 includes two axially extending tubes as shown in FIG. It consists of one flexible tube having flow holes 3a and 3b, and these flow holes 3a and 3b are formed at positions shifted from the axis Cr of the flexible tube (that is, the flow holes 3a and 3b are respectively formed). And one flow hole 3a is a part of the arterial blood circuit L1, and the other flow hole 3b is a part of the saline line L3.

  That is, one flow hole 3a is connected to the flexible tubes g and a to flow the patient's blood from the arterial puncture needle 1, and the other flow hole 3b is connected to the flexible tube f. The physiological saline guided from the container C is made to flow. Specifically, as shown in FIG. 4, the first connection pipe 8 includes a connection hole 8a for connecting the end of the integrated flexible tube 3, and a connection hole 8b for connecting the end of the flexible tube a. And a connection hole 8c for connecting the end of the flexible tube f.

  Of these, the connection hole 8a communicates with a flow passage 8ab extending from one flow hole 3a to the flexible tube a and a flow passage 8af extending from the other flow hole 3b to the flexible tube f. The circulation hole 3a and the flow path 8ab constitute a part of the arterial blood circuit L1, and the flexible tube f, the flow path 8af, and the other flow hole 3b constitute the saline line L3.

  Further, as shown in FIG. 5, the second connection pipe 9 has a connection hole 9 a for connecting the end of the flexible tube g and a connection hole 9 b for connecting the end of the integrated flexible tube 3. Of these, the connection hole 9a communicates with a flow passage 9aa extending to one flow hole 3a, and a flow passage 9ab extending from the middle of the flow passage 9aa to the other flow hole 3b is formed.

  Thereby, the blood of the patient collected from the arterial puncture needle 1 flows into the flexible tube g, the flow passage 9aa, and the one flow hole 3a of the integrated flexible tube 3, and the other flow hole 3b. The physiological saline that has flowed through the flow path 9ab reaches the flow path 9aa through the flow path 9ab, and flows into the other flow hole 3a of the integrated flexible tube 3. Therefore, physiological saline can be introduced into the arterial blood circuit L1.

  Here, as shown in FIG. 2, the thickness t1 constituting one flow hole 3a is designed to be thinner than the thickness t2 constituting the other flow hole 3b. The site | part of the said thickness t1 is soft. Thereby, when the inside of the circulation hole 3a becomes a negative pressure, as shown in FIG. 3, the negative pressure can be recognized by bending in the radial direction.

  That is, the flow hole 3a forms part of the arterial blood circuit L1 and also has a negative pressure detection function capable of detecting a negative pressure. This eliminates the need for a separate negative pressure detection member as in the prior art, and eliminates steps in the blood flow path, thereby suppressing the retention of blood during dialysis treatment and preventing residual blood after blood collection. can do. In addition, as for the range of the hardness in the site | part whose thickness is t1, HDA55-95 are preferable.

  Further, as shown in FIG. 2, the cross-sectional shape of one of the flow holes 3a is an ellipse, and the area of the thin wall portion (the portion in the range H in the figure) that is a portion for detecting negative pressure can be increased. Thus, the negative pressure can be detected more easily. In the present embodiment, the other circulation hole 3b is also elliptical in cross section, but it may be circular or rectangular in cross section.

  In order to perform dialysis treatment with the blood circuit having the above-described configuration, a part of the flexible tube f is sandwiched by a clamp device or the like, thereby closing the physiological saline flow path. The flow path of the flexible tube f is opened only at the time of previous priming, replacement fluid during dialysis treatment, or blood collection after dialysis treatment. When the flow path of the flexible tube f is opened, the physiological saline filled in the container C flows through the flexible tube f and then flows through the flow passage 8ac of the first connection pipe 8. To the other flow hole 3b.

  Then, the physiological saline that has flowed through the other flow hole 3b reaches the flow path 9aa from the flow path 9ab of the second connection tube 9, and is introduced into the arterial blood circuit L1. The physiological saline introduced into the arterial blood circuit L1 reaches the venous blood circuit L2 via the dialyzer 7 and is discharged from the venous puncture needle 2 at the time of priming or blood recovery, for example. It is supplied together with the patient.

  According to this embodiment, the integrated flexible tube has a function of flowing blood as a part of the arterial blood circuit L1, and a function of deflecting at the time of negative pressure to detect the negative pressure (the conventional negative pressure detecting member Dialysis treatment because it is difficult to bend and the flow path is inadvertently blocked due to bending, compared to a thin wall as a whole. Workability such as time can be maintained. That is, according to the present embodiment, since the negative pressure can be detected by a part of the arterial blood circuit L1, a separate negative pressure detecting member as in the prior art, which is supposed to cause residual blood, can be eliminated. Therefore, the configuration of the blood circuit can be simplified by eliminating the separate negative pressure detection member.

  Moreover, since the integrated flexible tube 3 is composed of one flexible tube 3 having two flow holes 3a and 3b, the tube can be manufactured by integral molding and manufactured separately. The manufacturing cost can be reduced compared to the above. For example, when a separately manufactured tube is joined with a string or the like, the arrangement site of the string or the like may be pressed, which may hinder blood flow, and when a separately manufactured tube is bonded with an adhesive or the like However, according to the present embodiment, the manufacturing cost can be suppressed while maintaining the fluidity of blood. The first connecting pipe 8 or the second connecting pipe 9 to which the end of the integrated flexible tube 3 should be connected may have other forms.

Next, a blood circuit according to another embodiment of the present invention will be described.
As shown in FIG. 6, the blood circuit according to the present embodiment is mainly composed of an arterial blood circuit L1 and a venous blood circuit L2. In the middle of these circuits L1 and L2, the blood pump 4 and the drip chamber (Arterial drip chamber 5 and venous drip chamber 6), dialyzer 7 and the like are connected. In addition, about the component similar to previous embodiment, the same code | symbol is attached | subjected and detailed description is abbreviate | omitted.

  In this embodiment, the flexible tube g connected to the connector 1 a is connected to the Y-shaped tube 13, and the first flexible tube 11 and the second flexible tube 12 are connected to the Y-shaped tube 13. Are extended in parallel. Of these, the first flexible tube 11 is connected to a T-shaped tube 10 as shown in FIG. 8 and is connected to a flexible tube f extending from the container C.

  As shown in the figure, the T-shaped tube 10 has a connection hole 10a for connecting the end of the flexible tube 11, and a connection hole 10b for connecting the end of the flexible tube f. A connection hole 10c communicating with 10a and 10b is closed by a closing member K. In addition, a flow passage 10ab that connects the connection holes 10a and 10b is formed in the T-shaped tube 10, and the communication passage 10ab, the flexible tube f, and the first flexible tube 11 are introduced into the liquid. The raw food line L3 as a line is comprised.

  In the first flexible tube 11 and the second flexible tube 12, as shown in FIG. 7, one flow hole 11a extending in the axial direction and the other 12a are formed, and each of them is a raw food. Part of the line L3 and part of the arterial blood circuit L1 are configured. As shown in the figure, the first flexible tube 11 and the second flexible tube 12 are joined and integrated with an adhesive in a close contact state. In addition, you may join by heat welding etc. other than what joins two flexible tubes with an adhesive agent in this way.

  Further, the wall thickness w1 of the second flexible tube 12 in which one flow hole 12a is formed is made thinner than the wall thickness w2 of the first flexible tube 11 in which the other flow hole 11a is formed. 2 The flexible tube 12 is softly formed. As a result, when a negative pressure is generated in the second flexible tube 12, the negative pressure can be detected because it bends in the radial direction, and the second flexible tube 12 is joined to the thick first flexible tube 11. Therefore, it is difficult to bend, and inadvertent blockage of the blood flow path can be avoided. In addition, as for the range of the hardness in the site | part whose thickness is w1, HDA55-95 is preferable like the previous embodiment.

  In addition, such a flexible tube having one flow hole 11a or 12a has been widely used conventionally, and various thicknesses thereof are prepared, so that a flexible tube having a desired thickness can be obtained. Two can be selected and joined to form part of the arterial blood circuit L1 and part of the saline line L3. Therefore, the blood circuit of this embodiment can be configured using an existing flexible tube (thickness selection is necessary).

  In order to perform dialysis treatment with the blood circuit having the above-described configuration, the physiological flow path is closed by holding a part of the flexible tube f or the first flexible tube 11 with a clamp device or the like. For example, the flow path is opened only during priming before dialysis treatment, replacement fluid during dialysis treatment, or blood collection after dialysis treatment. When the flow path is opened, the physiological saline filled in the container C flows through the flexible tube f, and then flows into the first flexible tube 11 through the flow passage 10ab of the T-shaped tube 10. To the Y-shaped tube 13.

  And since the physiological saline which reached the said Y-shaped pipe | tube 10 flows into the 2nd flexible tube 12 from there, it will be introduce | transduced into the artery side blood circuit L1. The physiological saline introduced into the arterial blood circuit L1 reaches the venous blood circuit L2 via the dialyzer 7 and is discharged from the venous puncture needle 2 at the time of priming or blood recovery, for example. It is supplied together with the patient.

  In the present embodiment, one first flexible tube 11 is provided from the Y-shaped tube 13 to the position where the T-shaped tube 10 is disposed, and second from the Y-shaped tube 13 to the large-diameter flexible tube 4a. Each of the flexible tubes 12 is disposed. For example, if a plurality of rubber buttons are connected in the middle, the second flexible tube 12 is connected only between adjacent rubber buttons, and the portion Only negative pressure may be detected.

  Although the two embodiments have been described above, the present invention is not limited to these embodiments. For example, instead of the saline line L3, another liquid introduction line for introducing a chemical solution or the like into the blood circuit may be used. Even in this case, at the site where the liquid introduction line and the arterial blood circuit are arranged in parallel, the thickness on the side of the arterial blood circuit is made softer and the internal negative pressure is detected. It is necessary to have a configuration that can do this.

  In this embodiment, the liquid introduction line (saline line L3) is connected to the arterial blood circuit L1, but instead of or together with this, it is applied to the one connected to the venous blood circuit L2. Also good. Further, other various components (for example, a bubble detector) may be connected to the blood circuit, and on the contrary, predetermined components (for example, a drip chamber on the artery side) may be omitted. Good.

  Furthermore, in the present embodiment, a double needle type having two puncture needles, ie, an artery side puncture needle 1 and a vein side puncture needle 2, is mentioned, but a single needle having one puncture needle is mentioned. You may make it apply to the thing of a type | mold.

  At least a part of the liquid introduction line is disposed in parallel with the arterial blood circuit or the venous blood circuit, and integrates the liquid introduction line and the arterial blood circuit or the venous blood circuit in the parallel part, The part constituting the arterial blood circuit or the venous side blood circuit in the integrated part is formed to be softer than the part constituting the liquid introduction line, and the negative pressure in the arterial blood circuit or the venous side blood circuit causes the radial direction As long as the blood circuit can be bent, the blood circuit can be applied to one having a different external shape or having another function added.

FIG. 1 is an overall schematic diagram showing a blood circuit according to an embodiment of the present invention. Sectional view taken along the line II-II in FIG. 1 (a state where no negative pressure is generated) Sectional schematic diagram which shows the state which the negative pressure produced in the flow hole 3a in the blood circuit which concerns on embodiment of this invention. Sectional schematic diagram which shows the 1st connection pipe in the blood circuit which concerns on embodiment of this invention. Sectional schematic diagram which shows the 2nd connection pipe in the blood circuit which concerns on embodiment of this invention. Overall schematic diagram showing a blood circuit according to another embodiment of the present invention. VII-VII line sectional view in FIG. Sectional schematic diagram which shows the T-shaped tube in the blood circuit which concerns on other embodiment of this invention. Overall schematic diagram showing a conventional blood circuit The front view which shows the negative pressure detection member arrange | positioned in the conventional blood circuit

Explanation of symbols

DESCRIPTION OF SYMBOLS 1 ... Arterial side puncture needle 1a, 2a ... Connector 2 ... Vein side puncture needle 3 ... Integrated flexible tube 4 ... Blood pump 4a ... Large diameter flexible tube 5, 6 ... Drip chamber 7 ... Dializer (blood purifier) )
DESCRIPTION OF SYMBOLS 8 ... 1st connection tube 9 ... 2nd connection tube 10 ... T-shaped tube 11 ... 1st flexible tube 12 ... 2nd flexible tube 13 ... Y-shaped tube L1 ... Arterial side blood circuit L2 ... Vein side blood circuit L3 ... Raw food line (liquid introduction line)

Claims (5)

An arterial blood circuit that is connected to the blood purifier and causes the blood collected from the puncture needle at the tip to flow to the blood purifier;
A venous blood circuit connected to the blood purifier, for flowing the blood from the blood purifier to the puncture needle at the tip, and returning it to the patient's body;
A liquid introduction line for introducing liquid into the arterial blood circuit or the venous blood circuit;
In a blood circuit having
At least a part of the liquid introduction line is arranged in parallel with the arterial blood circuit or venous blood circuit, and the liquid introduction line and the arterial blood circuit or venous blood circuit in the parallel part are integrated. In addition, the part constituting the arterial blood circuit or the venous side blood circuit in the integrated part is formed softer than the part constituting the liquid introduction line, and the negative pressure in the arterial blood circuit or the venous side blood circuit is formed. A blood circuit characterized by being able to bend in the radial direction.   The liquid introduction line is partially arranged in parallel with the arterial blood circuit or the venous blood circuit, and the tip extends to the vicinity of the puncture needle and is connected to the arterial blood circuit or the venous blood circuit. The blood circuit according to claim 1, comprising a saline line through which physiological saline can be introduced from the vicinity of the puncture needle.   The integrated portion is composed of one flexible tube having two flow holes extending in the axial direction, and the flow holes are formed at positions shifted from the axis of the flexible tube. The blood circuit according to claim 1 or 2, wherein the circulation hole is a part of the arterial blood circuit or the venous blood circuit, and the other circulation hole is a part of the liquid introduction line.   The blood circuit according to claim 3, wherein one of the flow holes in the flexible tube has an elliptical cross-sectional shape.   The integrated part is formed by joining two flexible tubes each formed with a flow hole extending in the axial direction, and one of the flow holes is part of the arterial blood circuit or the venous blood circuit. The blood circuit according to claim 1 or 2, wherein the other circulation hole is a part of the liquid introduction line.

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