JP2006321776A - Antibacterial mildewproofing agent of metal complex coordinated with amino acid and its secondary product - Google Patents
Antibacterial mildewproofing agent of metal complex coordinated with amino acid and its secondary product Download PDFInfo
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- JP2006321776A JP2006321776A JP2005172896A JP2005172896A JP2006321776A JP 2006321776 A JP2006321776 A JP 2006321776A JP 2005172896 A JP2005172896 A JP 2005172896A JP 2005172896 A JP2005172896 A JP 2005172896A JP 2006321776 A JP2006321776 A JP 2006321776A
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- mildewproofing agent
- amino acid
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本発明は 医療施設・食品加工場・容什器などを衛生的に良好な状態とする為施される抗菌防カビ剤について 誤って摂取しても 安全無害な薬剤を提供するものである。 The present invention provides an antibacterial and antifungal agent that is administered to make medical facilities, food processing plants, and containers well hygienic, and is safe and harmless even if ingested by mistake.
従来 医療施設・食品加工場・容什器などの衛生状況を改善する為に 大別して 次の５種の薬剤が採用されていた。
▲１▼過酸化物、 ▲２▼石炭酸系化合物、 ▲３▼ハロゲン系有機化合物、 ▲４▼砒素系有機化合物、 ▲５▼水銀、銀などの 必須ではない金属とその化合物
しかし それらは 少量且つ短期間の使用では 害も少なく有益であるが、効果が持続しない故に 頻繁に施す必要があり、常用すれば 蓄積毒や環境汚染の副作用の虞がある。
従って 常用しても安全無害で 且つ持続性のある抗菌防カビ剤の開発が待たれていた。Conventionally, the following five types of drugs have been adopted to improve the hygiene status of medical facilities, food processing plants, and containers.
(1) Peroxides, (2) Carcoic acid compounds, (3) Halogen organic compounds, (4) Arsenic organic compounds, (5) Non-essential metals and their compounds such as mercury, silver, etc. Short-term use is less harmful and beneficial, but it must be applied frequently because the effect does not last. If it is used regularly, there is a risk of side effects such as accumulated poisons and environmental pollution.
Therefore, the development of antibacterial and antifungal agents that are safe and harmless even when used regularly has been awaited.
安全無害である為に 抗菌防カビ原料として 必須アミノ酸と必須ミネラルのみを採用する事により、蓄積毒にも環境汚染にも成らず、程々の溶解度を選ぶ事により 徐放性・持続性もあり、安全無害で永続な抗菌防カビ剤を得る。 Because it is safe and harmless, by adopting only essential amino acids and essential minerals as antibacterial and antifungal raw materials, there is no accumulated poison or environmental pollution, and by selecting moderate solubility, there is also sustained release and sustainability, Get a safe, harmless and durable antibacterial fungicide.
錯体の配位子に必須アミノ酸を採用すれば 媒体との親和性がよく 成形・塗装・含浸・散布・霧化の何れの場合でも分散し易く、溶出性・徐放性・永続性も選択が可能となる。 If an essential amino acid is used for the ligand of the complex, the affinity with the medium is good and it is easy to disperse in any of molding, painting, impregnation, spraying, and atomization, and elution, sustained release, and permanence can be selected It becomes possible.
必須ミネラルとして 銅及び亜鉛を採用する事で 充分な抗菌防カビ効果が得られ、且つ 誤って生体内に摂取される事が有っても 必須ながら不足に成り易い銅と亜鉛はサプリメントとして積極的に摂取を促される程であるから、なんら案ずることは無い。 Adequate antibacterial and antifungal effects can be obtained by adopting copper and zinc as essential minerals, and copper and zinc that are likely to be deficient even if they are accidentally taken into the body are proactive as supplements It ’s so much that you ’re encouraged to take it.
配位子と金属を選択し 単一又は複合で錯体化する事により 媒体に対する溶解度・親和度 更に 電解度を調整する事ができ、徐放性・永続性を操縦する事が可能である。 By selecting a ligand and a metal and complexing them in a single or complex form, it is possible to adjust the solubility / affinity of the medium and the degree of electrolysis, and to control sustained release and permanence.
アミノ酸を２モル、金属を１モルからなる錯体は 配位式［Ｚｎ（ＮＨ２ＣＨＲＣＯＯ）２］で表記され、Ｒにアルキル基など種々の側鎖が充当される。 A complex composed of 2 moles of amino acid and 1 mole of metal is represented by a coordination formula [Zn (NH 2 CHRCOO) 2], and R is assigned various side chains such as an alkyl group.
バリン２モルとカルシウム１モル： ［Ｃａ｛（ＣＨ３）２ＣＨＣＨ（ＮＨ２）ＣＯＯ｝２］2 mols of valine and 1 mol of calcium: [Ca {(CH 3 ) 2 CHCH (NH 2 ) COO} 2 ]
ロイシン２モルとカリウム１モル： ［Ｋ｛（ＣＨ３）２ＣＨＣＨ２ＣＨ（ＮＨ２）ＣＯＯ｝２］2 moles of leucine and 1 mole of potassium: [K {(CH 3 ) 2 CHCH 2 CH (NH 2 ) COO} 2 ]
イソロイシン２モルと鉄１モル： ［Ｆｅ｛ＣＨ３ＣＨ２ＣＨ（ＣＨ３）ＣＨ（ＮＨ２）ＣＯＯ｝２］2 moles of isoleucine and 1 mole of iron: [Fe {CH 3 CH 2 CH (CH 3 ) CH (NH 2 ) COO} 2 ]
トレオニン２モルとマグネシウム１モル：［Ｍｇ｛ＣＨ３ＣＨ（ＯＨ）ＣＨ（ＮＨ２）ＣＯＯ｝２］2 moles of threonine and 1 mole of magnesium: [Mg {CH 3 CH (OH) CH (NH 2 ) COO} 2 ]
リジン２モルと亜鉛１モル： ［Ｚｎ｛ＮＨ２（ＣＨ２）ＣＨ（ＮＨ２）ＣＯＯ｝２］2 moles of lysine and 1 mole of zinc: [Zn {NH 2 (CH 2 ) CH (NH 2 ) COO} 2 ]
メチオニン２モルと銅１モル： ［Ｃｕ｛ＣＨ３ＳＣＨ２ＣＨ２ＣＨ（ＮＨ２）ＣＯＯ｝２］2 moles of methionine and 1 mole of copper: [Cu {CH 3 SCH 2 CH 2 CH (NH 2 ) COO} 2 ]
Claims (1)
バリン： （ＣＨ３）２ＣＨ ＣＨ（ＮＨ２）ＣＯＯＨ
ロイシン： （ＣＨ３）２ＣＨＣＨ２ＣＨ（ＮＨ２）ＣＯＯＨ
イソロイシン： ＣＨ３ＣＨ２ＣＨ（ＣＨ３）ＣＨ（ＮＨ２）ＣＯＯＨ
トレオニン： ＣＨ３ＣＨ（ＯＨ）ＣＨ（ＮＨ２）ＣＯＯＨ
リジン： ＮＨ２（ＣＨ２）ＣＨ（ＮＨ２）ＣＯＯＨ
フェニルアラニン：（Ｃ６Ｈ５）ＣＨ２ＣＨ（ＮＨ２）ＣＯＯＨ
トリプトファン： （ＮＣ６Ｈ６）ＣＨ２ＣＨ（ＮＨ２）ＣＯＯＨ
メチオニン： ＣＨ３ＳＣＨ２ＣＨ２ＣＨ（ＮＨ２）ＣＯＯＨ
システイン： ＨＳＣＨ２ＣＨ（ＮＨ２）ＣＯＯＨ
チスチン： ＳＣＨ２ＣＨ（ＮＨ２）ＣＯＯＨ
ＳＣＨ２ＣＨ（ＮＨ２）ＣＯＯＨAn antibacterial and antifungal agent, which is a metal complex in which an amino acid represented by the following general formula is coordinated to sodium, calcium, potassium, iron, magnesium, zinc or copper ions.
Valine: (CH 3) 2 CH CH (NH 2) COOH
Leucine: (CH 3 ) 2 CHCH 2 CH (NH 2 ) COOH
Isoleucine: CH 3 CH 2 CH (CH 3 ) CH (NH 2 ) COOH
Threonine: CH 3 CH (OH) CH (NH 2 ) COOH
Lysine: NH 2 (CH 2 ) CH (NH 2 ) COOH
Phenylalanine: (C 6 H 5 ) CH 2 CH (NH 2 ) COOH
Tryptophan: (NC 6 H 6 ) CH 2 CH (NH 2 ) COOH
Methionine: CH 3 SCH 2 CH 2 CH (NH 2 ) COOH
Cysteine: HSCH 2 CH (NH 2 ) COOH
Cystine: SCH 2 CH (NH 2 ) COOH
SCH 2 CH (NH 2 ) COOH
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2005172896A JP2006321776A (en) | 2005-05-18 | 2005-05-18 | Antibacterial mildewproofing agent of metal complex coordinated with amino acid and its secondary product |
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| Application Number | Priority Date | Filing Date | Title |
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| JP2005172896A JP2006321776A (en) | 2005-05-18 | 2005-05-18 | Antibacterial mildewproofing agent of metal complex coordinated with amino acid and its secondary product |
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| Publication Number | Publication Date |
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| JP2006321776A true JP2006321776A (en) | 2006-11-30 |
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| JP2005172896A Pending JP2006321776A (en) | 2005-05-18 | 2005-05-18 | Antibacterial mildewproofing agent of metal complex coordinated with amino acid and its secondary product |
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10106567B2 (en) | 2015-08-11 | 2018-10-23 | Akeso Biomedical, Inc. | Biofilm inhibiting compositions enhancing weight gain in livestock |
| US10195172B2 (en) | 2012-02-16 | 2019-02-05 | Akeso Biomedical, Inc. | Reduction of gastrointestinal tract colonisation by Campylobacter |
| US10264766B2 (en) | 2014-08-13 | 2019-04-23 | Akeso Biomedical, Inc. | Antimicrobial compounds and compositions, and uses thereof |
| US10653658B2 (en) | 2015-08-11 | 2020-05-19 | Akeso Biomedical, Inc. | Biofilm inhibiting compositions enhancing weight gain in livestock |
| CN111635537A (en) * | 2020-07-08 | 2020-09-08 | 浙江理工大学 | Metal-organic framework material and preparation method and application thereof |
-
2005
- 2005-05-18 JP JP2005172896A patent/JP2006321776A/en active Pending
Cited By (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10195172B2 (en) | 2012-02-16 | 2019-02-05 | Akeso Biomedical, Inc. | Reduction of gastrointestinal tract colonisation by Campylobacter |
| US10264766B2 (en) | 2014-08-13 | 2019-04-23 | Akeso Biomedical, Inc. | Antimicrobial compounds and compositions, and uses thereof |
| US10327423B2 (en) * | 2014-08-13 | 2019-06-25 | Akeso Biomedical, Inc. | Antimicrobial compounds and compositions, and uses thereof |
| US10106567B2 (en) | 2015-08-11 | 2018-10-23 | Akeso Biomedical, Inc. | Biofilm inhibiting compositions enhancing weight gain in livestock |
| US10301339B2 (en) | 2015-08-11 | 2019-05-28 | Akeso Biomedical, Inc. | Biofilm inhibiting compositions enhancing weight gain in livestock |
| US10377785B2 (en) | 2015-08-11 | 2019-08-13 | Akeso Biomedical, Inc. | Biofilm inhibiting compositions enhancing weight gain in livestock |
| US10555531B2 (en) | 2015-08-11 | 2020-02-11 | Akeso Biomedical, Inc. | Biofilm inhibiting compositions enhancing weight gain in livestock |
| US10647736B2 (en) | 2015-08-11 | 2020-05-12 | Akeso Biomedical, Inc. | Antimicrobial preparation and uses thereof |
| US10653658B2 (en) | 2015-08-11 | 2020-05-19 | Akeso Biomedical, Inc. | Biofilm inhibiting compositions enhancing weight gain in livestock |
| US10793587B2 (en) | 2015-08-11 | 2020-10-06 | Akeso Biomedical, Inc. | Biofilm inhibiting compositions enhancing weight gain in livestock |
| US11311511B2 (en) | 2015-08-11 | 2022-04-26 | Akeso Biomedical, Inc. | Biofilm inhibiting compositions enhancing weight gain in livestock |
| CN111635537A (en) * | 2020-07-08 | 2020-09-08 | 浙江理工大学 | Metal-organic framework material and preparation method and application thereof |
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