JP2006273722A - Method for producing organic compound - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To provide a method for obtaining an organic compound having less nitrogen-containing impurity content from a reaction mixture using a cyclic imide-based or cyclic acylurea-based compound catalyst in a good efficiency. <P>SOLUTION: This method for producing the organic compound by reacting a substrate in the presence of a catalyst of a cyclic imide-based compound or a cyclic acylurea-based compound, having a cyclic imide skeleton or a cyclic acylurea skeleton and expressed by formulae (I) or (II) [wherein, X is O or -OR (wherein R is H or a protecting group of hydroxy); (n) is 1 or 2, and when (n) is 2, two Gs are each the same or different] is characterized by subjecting the produced organic compound under a rinsing and/or re-pulping treatment to obtain the objective material reduced with the content of the nitrogen-containing impurity. <P>COPYRIGHT: (C)2007,JPO&INPIT

Description

  The present invention relates to a method for producing an organic compound using a cyclic imide or cyclic acylurea compound catalyst. More specifically, the present invention relates to a method for obtaining an organic compound having a low nitrogen-containing impurity content by subjecting a product obtained using a 6-membered cyclic imide-based or cyclic acylurea-based compound catalyst to a specific treatment.

  When a cyclic imide compound or a cyclic acylurea compound is used as a catalyst, various radical reactions proceed well for various substrates, and many useful organic compounds can be efficiently produced under mild conditions ( Patent Literatures 1 to 3). For example, in the presence of these catalysts, when an aromatic compound having an alkyl group bonded to an aromatic ring is oxidized with oxygen, the alkyl group is efficiently oxidized, and an aromatic carboxylic acid such as terephthalic acid or pyromellitic acid is industrially produced. Can be manufactured efficiently. In addition, when a non-aromatic cyclic hydrocarbon such as cyclohexane is oxidized with oxygen in the presence of the catalyst, an alcohol, hydroperoxide or ketone in which a hydroxyl group, a hydroperoxy group or an oxo group is introduced into a carbon atom constituting the ring Alternatively, depending on the reaction conditions, the corresponding dicarboxylic acid whose ring is oxidatively cleaved is obtained.

  However, depending on the product, if nitrogen-containing impurities are mixed, the product value may be significantly reduced. For example, polyvalent carboxylic acids such as terephthalic acid and pyromellitic acid are important compounds used as raw material monomers for polymers such as polyester and polyimide, but if nitrogen-containing impurities are contained, the polymerization reaction is inhibited by these impurities. Or the resulting polymer may become colored. Since the above-mentioned cyclic imide compounds and cyclic acylurea compounds have nitrogen atoms in the molecule, the reaction product using these compounds as a catalyst may adhere to nitrogen content derived from the catalyst. . In addition to polyvalent carboxylic acids, in many organic compounds, nitrogen-containing impurities often cause deterioration in product quality.

JP 2003-128618 A International Publication No. 03/28884 pamphlet WO03 / 55600 pamphlet

  Accordingly, an object of the present invention is to provide a method for efficiently obtaining an organic compound having a low nitrogen-containing impurity content from a reaction product using a 6-membered cyclic imide-based or cyclic acylurea-based compound catalyst.

  As a result of intensive investigations to achieve the above object, the present inventors perform a specific treatment on a product obtained by reacting a substrate in the presence of a 6-membered cyclic imide-based or cyclic acylurea-based compound catalyst. The present inventors have found that the nitrogen-containing impurities derived from the catalyst can be efficiently removed.

［式中、Ｘは酸素原子又は−ＯＲ基（Ｒは水素原子又はヒドロキシル基の保護基を示す）を示す。Ｇは炭素原子又は窒素原子を示す。ｎは１又は２を示し、ｎが２のとき、２つのＧは同一でもよく異なっていてもよい］
で表される環状イミド骨格又は環状アシルウレア骨格を有する環状イミド系又は環状アシルウレア系化合物触媒の存在下、基質を反応させて有機化合物を製造する方法において、生成した有機化合物をリンス及び／又はリパルプ処理に付して含窒素不純物含量の低減された目的物を得ることを特徴とする有機化合物の製造方法を提供する。 That is, the present invention provides the following formula (I) or (II)

[Wherein, X represents an oxygen atom or an —OR group (R represents a hydrogen atom or a protecting group for a hydroxyl group). G represents a carbon atom or a nitrogen atom. n represents 1 or 2, and when n is 2, two Gs may be the same or different.]
In the method of producing an organic compound by reacting a substrate in the presence of a cyclic imide-based or cyclic acylurea-based compound catalyst having a cyclic imide skeleton or a cyclic acylurea skeleton represented by the formula, the generated organic compound is rinsed and / or repulped. To provide a method for producing an organic compound characterized in that a target product having a reduced nitrogen-containing impurity content is obtained.

［式中、Ｘは酸素原子又は−ＯＲ基（Ｒは水素原子又はヒドロキシル基の保護基を示す）を示す。Ｒ¹、Ｒ²、Ｒ³、Ｒ⁴、Ｒ⁵及びＲ⁶は、同一又は異なって、水素原子、ハロゲン原子、アルキル基、アリール基、シクロアルキル基、ヒドロキシル基、アルコキシ基、カルボキシル基、置換オキシカルボニル基、アシル基又はアシルオキシ基を示し、Ｒ¹、Ｒ²、Ｒ³、Ｒ⁴、Ｒ⁵及びＲ⁶のうち少なくとも２つが互いに結合して二重結合、又は芳香族性若しくは非芳香族性の環を形成してもよい。前記Ｒ¹、Ｒ²、Ｒ³、Ｒ⁴、Ｒ⁵、Ｒ⁶、又はＲ¹、Ｒ²、Ｒ³、Ｒ⁴、Ｒ⁵及びＲ⁶のうち少なくとも２つが互いに結合して形成された二重結合又は芳香族性若しくは非芳香族性の環には、下記式（ａ）

（式中、Ｘは前記に同じ）
で表される環状イミド骨格がさらに１又は２個以上形成されていてもよい］
で表される化合物が含まれる。 The cyclic imide compound includes the following formula (1):

[Wherein, X represents an oxygen atom or an —OR group (R represents a hydrogen atom or a protecting group for a hydroxyl group). R ¹ , R ² , R ³ , R ⁴ , R ⁵ and R ⁶ are the same or different and are a hydrogen atom, halogen atom, alkyl group, aryl group, cycloalkyl group, hydroxyl group, alkoxy group, carboxyl group, substituted An oxycarbonyl group, an acyl group or an acyloxy group, wherein at least two of R ¹ , R ² , R ³ , R ⁴ , R ⁵ and R ⁶ are bonded to each other to form a double bond, or aromatic or non-aromatic Sex rings may be formed. ^{Two of} R ¹ , R ² , R ³ , R ⁴ , R ⁵ , R ⁶ , or at least two of R ¹ , R ² , R ³ , R ⁴ , R ⁵ and R ⁶ are bonded together. In the case of a heavy bond or an aromatic or non-aromatic ring, the following formula (a)

(Wherein X is the same as above)
Or one or more cyclic imide skeletons represented by
The compound represented by these is included.

（式中、Ｒは水素原子又はヒドロキシル基の保護基を示す。Ｒ^a、Ｒ^dは、同一又は異なって、水素原子、アルキル基、アリール基、シクロアルキル基、保護基で保護されていてもよいヒドロキシル基、保護基で保護されていてもよいカルボキシル基、又はアシル基を示し、Ｒ^b、Ｒ^cは、同一又は異なって、水素原子、ハロゲン原子、アルキル基、アリール基、シクロアルキル基、ヒドロキシル基、アルコキシ基、カルボキシル基、置換オキシカルボニル基、アシル基又はアシルオキシ基を示す。Ｒ^a、Ｒ^b、Ｒ^c、Ｒ^dのうち少なくとも２つが互いに結合して、式中の環を構成する原子とともに二重結合、又は芳香族性若しくは非芳香族性の環を形成してもよく、Ｒ^bとＲ^cは一体となってオキソ基を形成してもよい）
で表される化合物が含まれる。 The cyclic acylurea compound includes the following formula (2):

(In the formula, R represents a hydrogen atom or a protecting group for a hydroxyl group. R ^a and R ^d may be the same or different and may be protected with a hydrogen atom, an alkyl group, an aryl group, a cycloalkyl group or a protecting group. A good hydroxyl group, a carboxyl group which may be protected by a protecting group, or an acyl group, and R ^b and R ^c are the same or different and are a hydrogen atom, a halogen atom, an alkyl group, an aryl group, a cycloalkyl group, A hydroxyl group, an alkoxy group, a carboxyl group, a substituted oxycarbonyl group, an acyl group or an acyloxy group, at least two of R ^a , R ^b , R ^c and R ^d are bonded to each other to form a ring in the formula A double bond or an aromatic or non-aromatic ring may be formed together with an atom, and R ^b and R ^c may be combined to form an oxo group)
The compound represented by these is included.

  In the method for producing an organic compound, the organic compound to be subjected to rinsing and / or repulping is at least selected from the group consisting of an oxidation reaction, a nitration reaction, a carboxylation reaction, a sulfonation reaction, and a carbon-carbon bond formation reaction. Organic compounds produced by one reaction are included. Typical examples of the organic compound subjected to the rinsing and / or repulping treatment include polyvalent carboxylic acids such as aromatic polyvalent carboxylic acids.

  The solvent used for the rinsing and / or repulping treatment is preferably an organic acid.

  According to the present invention, a nitrogen-containing impurity derived from a catalyst is efficiently removed from a reaction product using a 6-membered cyclic imide-based or cyclic acylurea-based compound catalyst, and an organic compound having a low nitrogen-containing impurity content is easily obtained. be able to.

[Cyclic imide or cyclic acylurea compound catalyst]
In the present invention, a cyclic imide type or cyclic acyl urea type compound having a 6-membered cyclic imide skeleton or a cyclic acyl urea skeleton represented by the formula (I) or (II) is used as a catalyst.

  In the formulas (I) and (II), the bond between the nitrogen atom and X is a single bond or a double bond. The cyclic imide type or cyclic acyl urea type compound having a cyclic imide skeleton or a cyclic acyl urea skeleton represented by the formula (I) or (II) (hereinafter, these may be collectively referred to as “nitrogen atom-containing cyclic compounds”). The molecule may have a plurality of cyclic imide skeletons or cyclic acylurea skeletons represented by the formula (I) or (II). Further, in this nitrogen atom-containing cyclic compound, when X is an —OR group and R is a hydroxyl-protecting group, the portion other than R in the skeleton represented by the formula (I) or (II) A plurality of them may be bonded via R.

As the protecting group for the hydroxyl group represented by R, a protecting group for a hydroxyl group commonly used in the field of organic synthesis can be used. Examples of such protecting groups include alkyl groups (eg, C _1-4 alkyl groups such as methyl and t-butyl groups), alkenyl groups (eg, allyl groups), cycloalkyl groups (eg, cyclohexyl groups, etc.) ), Aryl groups (eg, 2,4-dinitrophenyl group, etc.), aralkyl groups (eg, benzyl, 2,6-dichlorobenzyl, 3-bromobenzyl, 2-nitrobenzyl, triphenylmethyl groups, etc.); substituted methyl Groups such as methoxymethyl, methylthiomethyl, benzyloxymethyl, t-butoxymethyl, 2-methoxyethoxymethyl, 2,2,2-trichloroethoxymethyl, bis (2-chloroethoxy) methyl, 2- (trimethylsilyl) ethoxy Methyl group), substituted ethyl group (for example, 1-ethoxyethyl, 1-methyl) -1-methoxyethyl, 1-isopropoxyethyl, 2,2,2-trichloroethyl, 2-methoxyethyl group, etc.), tetrahydropyranyl group, tetrahydrofuranyl group, 1-hydroxyalkyl group (for example, 1-hydroxyethyl group) A group capable of forming an acetal or hemiacetal group with a hydroxyl group such as 1-hydroxyhexyl, 1-hydroxydecyl, 1-hydroxyhexadecyl, 1-hydroxy-1-phenylmethyl group, etc .; an acyl group (for example, Aliphatic saturated or unsaturated such as C _1-20 aliphatic acyl groups such as formyl, acetyl, propionyl, butyryl, isobutyryl, valeryl, pivaloyl, hexanoyl, heptanoyl, octanoyl, nonanoyl, decanoyl, lauroyl, myristoyl, palmitoyl, stearoyl groups A Acetoacetyl group; alicyclic acyl group such as cycloalkanecarbonyl group such as cyclopentanecarbonyl and cyclohexanecarbonyl group; aromatic acyl group such as benzoyl and naphthoyl group), sulfonyl group (methanesulfonyl, ethanesulfonyl, Trifluoromethanesulfonyl, benzenesulfonyl, p-toluenesulfonyl, naphthalenesulfonyl groups, etc.), alkoxycarbonyl groups (for example, C _1-4 alkoxy-carbonyl groups such as methoxycarbonyl, ethoxycarbonyl, t-butoxycarbonyl groups, etc.), aralkyloxy Carbonyl group (for example, benzyloxycarbonyl group, p-methoxybenzyloxycarbonyl group, etc.), substituted or unsubstituted carbamoyl group (for example, carbamoyl, methylcarbamoyl, phenyl) Rubamoyl group), inorganic acid (sulfuric acid, nitric acid, phosphoric acid, boric acid, etc.), OH group removed, dialkylphosphinothioyl group (for example, dimethylphosphinothioyl group, etc.), diarylphosphinothioyl Group (for example, diphenylphosphinothioyl group), substituted silyl group (for example, trimethylsilyl, t-butyldimethylsilyl, tribenzylsilyl, triphenylsilyl group, etc.) and the like.

  In the case where X is an -OR group, a plurality of portions excluding R (N-oxycyclic imide skeleton or N-oxycyclic acylurea skeleton) in the skeleton represented by formula (I) or (II), In the case of bonding via R, as R, for example, an acyl group such as an oxalyl, malonyl, succinyl, glutaryl, adipoyl, phthaloyl, isophthaloyl, terephthaloyl group, etc .; a carbonyl group; And polyvalent hydrocarbon groups (particularly, groups that form an acetal bond with two hydroxyl groups) such as a lidene, cyclohexylidene, and benzylidene group.

  Preferable R includes, for example, a hydrogen atom; a group capable of forming an acetal or hemiacetal group with a hydroxyl group; an OH group is removed from an acid such as carboxylic acid, sulfonic acid, carbonic acid, carbamic acid, sulfuric acid, phosphoric acid or boric acid. Hydrolyzable protecting groups that can be removed by hydrolysis of the group (acyl group, sulfonyl group, alkoxycarbonyl group, carbamoyl group, etc.).

As a typical example of the cyclic imide compound having a 6-membered cyclic imide skeleton represented by the formula (I), a compound represented by the formula (1) may be mentioned. X is the same as described above. R ¹ , R ² , R ³ , R ⁴ , R ⁵ and R ⁶ are the same or different and are a hydrogen atom, halogen atom, alkyl group, aryl group, cycloalkyl group, hydroxyl group, alkoxy group, carboxyl group, substituted An oxycarbonyl group, an acyl group or an acyloxy group is shown.

  The halogen atom includes iodine, bromine, chlorine and fluorine atoms. Examples of the alkyl group include about 1 to 30 carbon atoms such as methyl, ethyl, propyl, isopropyl, butyl, isobutyl, s-butyl, t-butyl, hexyl, decyl, dodecyl, tetradecyl, and hexadecyl groups (particularly carbon number). About 1 to 20) linear or branched alkyl group.

  Aryl groups include phenyl, tolyl, xylyl, naphthyl groups, and the like, and cycloalkyl groups include cyclopentyl, cyclohexyl groups, and the like. The alkoxy group includes, for example, about 1 to 30 carbon atoms such as methoxy, ethoxy, isopropoxy, butoxy, t-butoxy, hexyloxy, octyloxy, decyloxy, dodecyloxy, tetradecyloxy, octadecyloxy groups (particularly carbon An alkoxy group of about 1 to 20).

Substituted oxycarbonyl groups include, for example, C _1-30 alkoxy-carbonyl groups such as methoxycarbonyl, ethoxycarbonyl, isopropoxycarbonyl, butoxycarbonyl, t-butoxycarbonyl, hexyloxycarbonyl, decyloxycarbonyl, hexadecyloxycarbonyl groups, etc. (Especially C _1-20 alkoxy-carbonyl group); cycloalkyloxycarbonyl group such as cyclopentyloxycarbonyl, cyclohexyloxycarbonyl group (especially 3-20 membered cycloalkyloxycarbonyl group); phenyloxycarbonyl, naphthyloxycarbonyl group aryloxycarbonyl group such as (in particular, C _6-20 aryloxy - carbonyl group); aralkyloxycarbonyl group such as benzyloxycarbonyl group (particularly, C _7-21 Ala Kiruokishi - carbonyl group).

Examples of the acyl group include C _1-30 aliphatic acyl groups such as formyl, acetyl, propionyl, butyryl, isobutyryl, valeryl, pivaloyl, hexanoyl, octanoyl, decanoyl, lauroyl, myristoyl, palmitoyl, stearoyl groups (particularly, C ₁ Aliphatic saturated or unsaturated acyl groups such as _-20 aliphatic acyl groups; acetoacetyl groups; alicyclic acyl groups such as cycloalkanecarbonyl groups such as cyclopentanecarbonyl and cyclohexanecarbonyl groups; aromatics such as benzoyl and naphthoyl groups Group acyl groups and the like.

Examples of the acyloxy group include formyloxy, acetyloxy, propionyloxy, butyryloxy, isobutyryloxy, valeryloxy, pivaloyloxy, hexanoyloxy, octanoyloxy, decanoyloxy, lauroyloxy, myristoyloxy, palmitoyloxy, stearoyloxy Aliphatic saturated or unsaturated acyloxy groups such as C _1-30 aliphatic acyloxy groups (particularly C _1-20 aliphatic acyloxy groups); acetoacetyloxy groups; cyclopentanecarbonyloxy, cyclohexanecarbonyloxy groups, etc. Examples thereof include alicyclic acyloxy groups such as cycloalkanecarbonyloxy group; aromatic acyloxy groups such as benzoyloxy and naphthoyloxy groups.

In the formula (1), at least two of R ¹ , R ² , R ³ , R ⁴ , R ⁵ and R ⁶ are bonded to each other to form a carbon atom or carbon-carbon bond constituting a cyclic imide skeleton, A double bond or an aromatic or non-aromatic ring may be formed. A preferable aromatic or non-aromatic ring is a 5- to 12-membered ring, particularly a 6- to 10-membered ring, and may be a heterocyclic ring or a condensed heterocyclic ring, but is often a hydrocarbon ring. Such a ring includes, for example, a non-aromatic alicyclic ring (a cycloalkene ring which may have a substituent such as a cyclohexane ring and a cycloalkene ring which may have a substituent such as a cyclohexene ring). Ring), non-aromatic bridged ring (such as bridged hydrocarbon ring optionally having substituent such as 5-norbornene ring), benzene ring, naphthalene ring and the like Also included are aromatic rings (including fused rings). The ring is often composed of an aromatic ring. The ring has a substituent such as an alkyl group, a haloalkyl group, a hydroxyl group, an alkoxy group, a carboxyl group, a substituted oxycarbonyl group, an acyl group, an acyloxy group, a nitro group, a cyano group, an amino group, and a halogen atom. Also good.

^{Two of} R ¹ , R ² , R ³ , R ⁴ , R ⁵ , R ⁶ , or at least two of R ¹ , R ² , R ³ , R ⁴ , R ⁵ and R ⁶ are bonded together. One or more N-substituted cyclic imide groups represented by the formula (a) may be further formed in the heavy bond or the aromatic or non-aromatic ring. For example, when R ¹ , R ² , R ³ , R ⁴ , R ^5, or R ⁶ is an alkyl group having 2 or more carbon atoms, the N-substituted group containing two adjacent carbon atoms constituting the alkyl group A cyclic imide group may be formed. When at least two of R ¹ , R ² , R ³ , R ⁴ , R ⁵ and R ⁶ are bonded to each other to form a double bond together with the carbon-carbon bond constituting the cyclic imide skeleton, The N-substituted cyclic imide group may be formed including a heavy bond.

（式中、Ｒ¹¹〜Ｒ¹⁶は、同一又は異なって、水素原子、ハロゲン原子、アルキル基、アリール基、シクロアルキル基、ヒドロキシル基、アルコキシ基、カルボキシル基、置換オキシカルボニル基、アシル基又はアシルオキシ基を示す。Ｒ²¹〜Ｒ²⁶は、同一又は異なって、水素原子、アルキル基、ハロアルキル基、ヒドロキシル基、アルコキシ基、カルボキシル基、置換オキシカルボニル基、アシル基、アシルオキシ基、ニトロ基、シアノ基、アミノ基、ハロゲン原子を示す。Ｒ²¹〜Ｒ²⁶は、隣接する基同士が結合して、前記式（ａ）で表される環状イミド骨格をさらに１又は２以上形成していてもよい。Ｘは前記に同じ） Preferred cyclic imide compounds include compounds represented by the following formula.

(Wherein R ^{11 to} R ¹⁶ are the same or different and each represents a hydrogen atom, halogen atom, alkyl group, aryl group, cycloalkyl group, hydroxyl group, alkoxy group, carboxyl group, substituted oxycarbonyl group, acyl group or acyloxy group) R ^{21 to} R ²⁶ are the same or different and each represents a hydrogen atom, an alkyl group, a haloalkyl group, a hydroxyl group, an alkoxy group, a carboxyl group, a substituted oxycarbonyl group, an acyl group, an acyloxy group, a nitro group, or a cyano group. R ^{21 to} R ²⁶ may further form one or more cyclic imide skeletons represented by the formula (a) by bonding adjacent groups to each other. X is the same as above)

Halogen atom in the substituents R ¹¹ to R ^16, an alkyl group, an aryl group, a cycloalkyl group, a hydroxyl group, an alkoxy group, a carboxyl group, substituted oxycarbonyl group, an acyl group, the acyloxy group, in the R ¹ to R ⁶ Examples corresponding to the corresponding groups are exemplified. In the substituents R ^{21 to} R ²⁶ , the alkyl group includes the same alkyl group as the above exemplified alkyl group, particularly an alkyl group having about 1 to 6 carbon atoms, and the haloalkyl group includes a trifluoromethyl group and the like. For haloalkyl groups and alkoxy groups having about 1 to 4 carbon atoms, the same alkoxy groups as described above, particularly for lower alkoxy groups having about 1 to 4 carbon atoms and substituted oxycarbonyl groups, the same substituted oxycarbonyl groups ( Alkoxycarbonyl group, cycloalkyloxycarbonyl group, aryloxycarbonyl group, aralkyloxycarbonyl group and the like). Examples of the acyl group include the same acyl groups as described above (aliphatic saturated or unsaturated acyl group, acetoacetyl group, alicyclic acyl group, aromatic acyl group, etc.), and the acyloxy group is the same as described above. And an acyloxy group (aliphatic saturated or unsaturated acyloxy group, acetoacetyloxy group, alicyclic acyloxy group, aromatic acyloxy group, etc.). Examples of halogen atoms include fluorine, chlorine and bromine atoms. The substituents R ^{21 to} R ²⁶ are usually a hydrogen atom, a lower alkyl group having about 1 to 4 carbon atoms, a carboxyl group, a substituted oxycarbonyl group, a nitro group, or a halogen atom in many cases.

  Representative examples of preferred cyclic imide compounds include, for example, N-hydroxyglutarimide, N-hydroxy-α, α-dimethylglutarimide, N-hydroxy-β, β-dimethylglutarimide, N-hydroxy-1, 8-decalin dicarboxylic acid imide, N, N′-dihydroxy-1,8; 4,5-decalin tetracarboxylic acid diimide, N-hydroxy-1,8-naphthalenedicarboxylic acid imide (N-hydroxynaphthalic acid imide), N, N'-dihydroxy-1,8; 4,5-naphthalenetetracarboxylic acid diimide and the like, wherein X is an -OR group and R is a hydrogen atom; corresponding to these compounds, R Wherein N is an acyl group such as an acetyl group, a propionyl group or a benzoyl group; N-methoxymethyloxy-1,8-naphth In formula (1) such as dicarboxylic acid imide, N, N′-bis (methoxymethyloxy) -1,8; 4,5-naphthalenetetracarboxylic acid diimide, X is an —OR group, and R is a hydroxyl group and an acetal Or a compound which is a group capable of forming a hemiacetal bond; N-methanesulfonyloxy-1,8-naphthalenedicarboxylic imide, N, N′-bis (methanesulfonyloxy) -1,8; 4,5-naphthalenetetra Compound in which X in formula (1) such as carboxylic acid diimide is —OR group and R is sulfonyl group; N-hydroxy-1,8-naphthalenedicarboxylic imide or N, N′-dihydroxy-1,8; 4 , 5-naphthalenetetracarboxylic acid diimide sulfate ester, nitrate ester, phosphate ester or borate ester (1 ) In which X is an —OR group and R is a group obtained by removing an OH group from an inorganic acid.

  In addition to the cyclic imide compound, the nitrogen atom-containing cyclic compound includes a cyclic acylurea skeleton [—C (═O) —N—C (═O) —N—] represented by the formula (II). The cyclic acylurea-type compound which has is included. The atom G constituting the cyclic acylurea skeleton and the nitrogen atom bonded to the G may have various substituents, and the cyclic acylurea skeleton has a non-aromatic or aromatic ring. It may be condensed. Furthermore, the cyclic acylurea skeleton may have a double bond in the ring.

（式中、Ｒは前記に同じ） The cyclic acylurea skeleton represented by the formula (II) includes a 3-hydroxy (or 3-substituted oxy) hydantoin skeleton represented by the following formula (IIa), a 4-hydroxy (or the formula (IIb) 4-substituted oxy) -1,2,4-triazolidine-3,5-dione skeleton [including 4-hydroxy (or 4-substituted oxy) -1,2,4-triazoline-3,5-dione skeleton], Hydro-3-hydroxy (or 3-substituted oxy) -1,3-diazine-2,4-dione skeleton represented by formula (IIc) [hexahydro-1-hydroxy (or 1-substituted oxy) -1,3 -Diazine-2,4,6-trione skeleton, hexahydro-1,3-dihydroxy (or 1,3-bis-substituted oxy) -1,3-diazine-2,4,6-trione skeleton, 3-hydroxy (or 3-substituted oxy) ura A hydro-4-hydroxy (or 4-substituted oxy) -1,2,4-triazine-3,5-dione skeleton represented by the formula (IId) Hydro-1-hydroxy (or 1-substituted oxy) -1,3,5-triazine-2,6-dione skeleton, and hydro-5-hydroxy (or 5-substituted oxy)-represented by formula (IIf) A 1,2,3,5-tetrazine-4,6-dione skeleton is included.

(Wherein R is the same as above)

A typical example of the cyclic acylurea compound is a hydro-1-hydroxy (or 1-substituted oxy) -1,3,5-triazine-2,6-dione compound represented by the formula (2). . In formula (2), R ^a and R ^d are the same or different and are protected with a hydrogen atom, an alkyl group, an aryl group, a cycloalkyl group, a hydroxyl group which may be protected with a protecting group, or a protecting group. R ^b and R ^c may be the same or different and each represents a hydrogen atom, a halogen atom, an alkyl group, an aryl group, a cycloalkyl group, a hydroxyl group, an alkoxy group, a carboxyl group, a substituted oxy group. A carbonyl group, an acyl group or an acyloxy group is shown. Even if at least two of R ^a , R ^b , R ^c and R ^d are bonded to each other to form a double bond or an aromatic or non-aromatic ring with the atoms constituting the ring in the formula R ^b and R ^c may together form an oxo group. R is the same as described above.

Examples of the alkyl group, aryl group, cycloalkyl group, and acyl group in R ^a and R ^d are the same as the alkyl groups in R ^{1 to} R ⁶ described above. Examples of the protecting group for the hydroxyl group include those described above. Examples of the protecting group for the carboxyl group include protecting groups commonly used in the field of organic synthesis, such as alkoxy groups (for example, C _1-6 alkoxy groups such as methoxy, ethoxy, butoxy, etc.), cycloalkyloxy groups, aryloxy groups ( For example, phenoxy group etc.) aralkyloxy group (eg benzyloxy group etc.), trialkylsilyloxy group (eg trimethylsilyloxy group etc.), optionally substituted amino group (eg amino group; methyl And mono- or di-C _1-6 alkylamino groups such as amino group and dimethylamino group).

As the halogen atom, alkyl group, aryl group, cycloalkyl group, hydroxyl group, alkoxy group, carboxyl group, substituted oxycarbonyl group, acyl group, and acyloxy group in R ^b and R ^c , the alkyl group in R ^{1 to} R ⁶ above. The same thing is illustrated.

  Representative examples of preferable cyclic acylurea compounds include, for example, 3-hydroxyhydantoin, 1,3-dihydroxyhydantoin, 3-hydroxy-1-methylhydantoin, 3-acetoxyhydantoin, 1,3-diacetoxyhydantoin, 3- Compounds having a skeleton represented by the formula (IIa) such as acetoxy-1-methylhydantoin; 4-hydroxy-1,2,4-triazolidine-3,5-dione, 4-hydroxy-1,2-dimethyl-1 2,4-triazolidine-3,5-dione, 4-acetoxy-1,2,4-triazolidine-3,5-dione, 4-acetoxy-1,2-dimethyl-1,2,4-triazolidine-3 , 5-dione, 4-hydroxy-1,2,4-triazoline-3,5-dione, 4-acetoxy-1,2,4 Compounds having a skeleton represented by the formula (IIb) such as triazoline-3,5-dione; hexahydro-3-hydroxy-1,3-diazine-2,4-dione, hexahydro-1,3-dihydroxy-1, 3-diazine-2,4-dione, hexahydro-3-hydroxy-1-methyl-1,3-diazine-2,4-dione, 3-acetoxy-hexahydro-1,3-diazine-2,4-dione, 1,3-diacetoxy-hexahydro-1,3-diazine-2,4-dione, 3-acetoxy-hexahydro-1-methyl-1,3-diazine-2,4-dione, hexahydro-1-hydroxy-1, 3-diazine-2,4,6-trione, 1-acetoxy-hexahydro-1,3-diazine-2,4,6-trione, hexahydro-1,3-dihydroxy -1,3-diazine-2,4,6-trione, 1,3-diacetoxy-hexahydro-1,3-diazine-2,4,6-trione, 3-hydroxyuracil, 3-acetoxyuracil and the like ( IIc) compound having a skeleton represented by: hexahydro-4-hydroxy-1,2,4-triazine-3,5-dione, hexahydro-4-hydroxy-1,2-dimethyl-1,2,4-triazine 3,5-dione, 4-acetoxy-hexahydro-1,2,4-triazine-3,5-dione, 4-acetoxy-hexahydro-1,2-dimethyl-1,2,4-triazine-3,5 A compound having a skeleton represented by the formula (IId) such as dione; hexahydro-1,3,5-trihydroxy-1,3,5-triazine-2,4,6-trione, 1,3,5- Triacetoxy-hexahydro-1,3,5-triazine-2,4,6-trione, hexahydro-1-hydroxy-1,3,5-triazine-2,6-dione, hexahydro-1-hydroxy-3,5 -Dimethyl-1,3,5-triazine-2,6-dione, 1-acetoxy-hexahydro-1,3,5-triazine-2,6-dione, 1-acetoxy-hexahydro-3,5-dimethyl-1 , 3,5-triazine-2,6-dione and the like having a skeleton represented by the formula (IIe) [for example, a compound represented by the formula (2)]; hexahydro-5-hydroxy-1,2, 3,5-tetrazine-4,6-dione, hexahydro-5-hydroxy-1,2,3-trimethyl-1,2,3,5-tetrazine-4,6-dione, 5-acetoxy-hexahi Formulas such as b-1,2,3,5-tetrazine-4,6-dione, 5-acetoxy-hexahydro-1,2,3-trimethyl-1,2,3,5-tetrazine-4,6-dione And a compound having a skeleton represented by (IIf).

  Among the nitrogen atom-containing cyclic compounds, a compound in which X is an —OR group and R is a hydrogen atom (N-hydroxy cyclic compound) can be produced according to a known method or by a combination of known methods. it can. Among the nitrogen atom-containing cyclic compounds, a compound in which X is an —OR group and R is a protecting group for a hydroxyl group is a conventional compound (N-hydroxy cyclic compound) in which R is a hydrogen atom. It can be prepared by introducing a desired protecting group using a protecting group introduction reaction.

  Specifically, among the cyclic imide compounds, a compound in which X is an —OR group and R is a hydrogen atom (N-hydroxy cyclic imide compound) is a conventional imidization reaction, for example, a corresponding acid anhydride. Can be obtained by a method of reacting with hydroxylamine and imidizing via ring opening and ring closing of an acid anhydride group. For example, N-acetoxyphthalimide can be obtained by reacting N-hydroxyphthalimide with acetic anhydride or reacting acetyl halide in the presence of a base. It is also possible to manufacture by other methods.

  Among the cyclic acylurea compounds, for example, 1,3,5-triacetoxy-hexahydro-1,3,5-triazine-2,4,6-trione (= 1,3,5-triacetoxyisocyanuric acid) is , Hexahydro-1,3,5-trihydroxy-1,3,5-triazine-2,4,6-trione (= 1,3,5-trihydroxyisocyanuric acid) and acetic anhydride, It can be obtained by reacting acetyl halide in the presence.

  The nitrogen atom-containing cyclic compound containing a skeleton represented by formula (I) or (II) as a ring component can be used alone or in combination of two or more in the reaction. For example, a cyclic imide compound having a cyclic imide skeleton represented by formula (I) and a cyclic acylurea compound having a cyclic acylurea skeleton represented by formula (II) can be used in combination. The nitrogen atom-containing cyclic compound catalyst may be generated in the reaction system. The nitrogen atom-containing cyclic compound catalyst may be used in a form supported on a carrier. As the carrier, porous carriers such as activated carbon, zeolite, silica, silica-alumina and bentonite are often used. The amount of the nitrogen atom-containing cyclic compound supported on the carrier is, for example, 0.1 to 50 parts by weight, preferably 0.5 to 30 parts by weight, and more preferably about 1 to 20 parts by weight with respect to 100 parts by weight of the carrier. is there.

  The amount of the nitrogen atom-containing cyclic compound catalyst used can be selected within a wide range. For example, 0.0000001 to 1 mol, preferably 0.000001 to 0.5 mol, more preferably, with respect to 1 mol of the reaction component (substrate). Is about 0.00001 to 0.4 mol.

[Cocatalyst]
In the present invention, a promoter may be used together with the nitrogen atom-containing cyclic compound catalyst. Examples of the cocatalyst include metal compounds. By using the nitrogen atom-containing cyclic compound catalyst and the metal compound in combination, the reaction rate and the selectivity of the reaction can be improved.

  Although it does not specifically limit as a metal element which comprises a metal compound, The periodic table 1-15 group metal element is used in many cases. In this specification, boron B is also included in the metal element. Preferred metal elements include transition metal elements (periodic group 3-12 elements). Of these, Mn, Co, Zr, Ce, Fe, V, Mo and the like are preferable, and Mn and Co are particularly preferable. Moreover, activity may be improved by using a transition metal element in combination with a periodic table group 1 or group 2 element. The valence of the metal element is not particularly limited, and is about 0 to 6, for example.

Examples of the metal compound include simple substances, hydroxides, oxides (including composite oxides), halides (fluorides, chlorides, bromides, iodides), oxo acid salts (eg, nitrates, sulfates) of the above metal elements. , Phosphates, borates, carbonates, etc.), inorganic compounds such as isopolyacid salts, heteropolyacid salts; organic acid salts (eg acetate, propionate, cyanate, naphthenate, stearic acid) Salt) and organic compounds such as complexes. The ligands constituting the complex include OH (hydroxo), alkoxy (methoxy, ethoxy, propoxy, butoxy, etc.), acyl (acetyl, propionyl, etc.), alkoxycarbonyl (methoxycarbonyl, ethoxycarbonyl, etc.), acetylacetonato , Cyclopentadienyl group, halogen atom (chlorine, bromine, etc.), CO, CN, oxygen atom, H ₂ O (aquo), phosphine (triarylphosphine such as triphenylphosphine), phosphorus compound, NH ₃ (ammine) ), NO, NO ₂ (nitro), NO ₃ (nitrato), nitrogen-containing compounds such as ethylenediamine, diethylenetriamine, pyridine and phenanthroline.

  Specific examples of the metal compound include, for example, a cobalt compound, inorganic compounds such as cobalt hydroxide, cobalt oxide, cobalt chloride, cobalt bromide, cobalt nitrate, cobalt sulfate, and cobalt phosphate; cobalt acetate, naphthene Examples thereof include organic acid salts such as cobalt acid and cobalt stearate; divalent or trivalent cobalt compounds such as complexes such as cobalt acetylacetonate. Examples of vanadium compounds include inorganic compounds such as vanadium hydroxide, vanadium oxide, vanadium chloride, vanadyl chloride, vanadium sulfate, vanadyl sulfate, and sodium vanadate; complexes such as vanadium acetylacetonate and vanadylacetylacetonate Examples thereof include divalent to pentavalent vanadium compounds. Furthermore, examples of sodium compounds that are Group 1 element compounds of the periodic table include inorganic compounds (including simple metals) such as sodium, sodium hydroxide, sodium carbonate, sodium bicarbonate, sodium chloride, sodium sulfate; sodium methoxide, Organic compounds such as sodium ethoxide, sodium acetate, sodium benzoate, sodium p-toluenesulfonate, and the like can be mentioned. Examples of other metal element compounds include compounds corresponding to the cobalt compounds, vanadium compounds, and sodium compounds. A metal compound can be used individually or in combination of 2 or more types. In particular, when a cobalt compound, a manganese compound, and optionally a zirconium compound are combined, the reaction rate is often significantly improved. It is also preferable to use a combination of a plurality of metal compounds having different valences (for example, a divalent metal compound and a trivalent metal compound). Further, when a catalyst in which X is an —OR group and R is a protecting group for a hydroxyl group in the formula (I) or (II) is used, a transition metal element compound such as a cobalt compound and a periodic table are used as the metal compound. When used in combination with a Group 1 element or Group 2 element compound, a high catalytic activity can be obtained even in a reaction in a non-acidic solvent or an aprotic solvent, and the reaction between the substrate and the catalyst can be suppressed. .

  The usage-amount of the said metal compound is 0.0001-10 mol with respect to 1 mol of said nitrogen atom containing cyclic compound catalysts, for example, Preferably it is about 0.005-3 mol. Moreover, the usage-amount of a metal compound is 0.00001 mol%-10 mol% with respect to 1 mol of reaction components (substrate), Preferably it is about 0.1 mol%-5 mol%.

  In the present invention, as the promoter, an organic salt composed of a polyatomic cation or polyatomic anion containing a group 15 or 16 element of the periodic table to which at least one organic group is bonded and a counter ion is used. You can also. By using the organic salt as a cocatalyst, the reaction rate and the selectivity of the reaction can be improved. The group 15 element of the periodic table includes N, P, As, Sb, and Bi. Periodic table group 16 elements include O, S, Se, Te and the like. Preferable elements include N, P, As, Sb, and S, and N, P, and S are particularly preferable. Representative examples of the organic salt include organic ammonium salts such as tetrabutylammonium chloride, organic phosphonium salts such as tetrabutylphosphonium chloride, and organic onium salts such as organic sulfonium salts such as triethylsulfonium iodide. The usage-amount of organic salt is about 0.001-0.1 mol with respect to 1 mol of said nitrogen atom containing cyclic compounds, Preferably it is about 0.005-0.08 mol.

  In the present invention, a strong acid (for example, a compound having a pKa2 (25 ° C.) or lower) can also be used as a cocatalyst. Preferred strong acids include, for example, hydrogen halides, hydrohalic acids, sulfuric acids, heteropoly acids and the like. The amount of the strong acid used is, for example, about 0.001 to 3 mol with respect to 1 mol of the nitrogen atom-containing cyclic compound catalyst.

  In the present invention, a compound having a carbonyl group to which an electron withdrawing group is bonded can also be used as a promoter. Typical examples of the compound having a carbonyl group to which an electron withdrawing group is bonded include hexafluoroacetone, trifluoroacetic acid, pentafluorophenyl ketone, pentafluorophenyl ketone, and benzoic acid. The amount of the compound used is, for example, about 0.0001 to 3 mol with respect to 1 mol (preparation basis) of the reaction component (substrate).

  In the present invention, a radical generator or a radical reaction accelerator may be present in the system. Examples of such components include hydrous such as halogen (chlorine, bromine, etc.), peracid (peracetic acid, m-chloroperbenzoic acid, etc.), peroxide (hydrogen peroxide, t-butyl hydroperoxide (TBHP), etc. Peroxide), nitric acid or nitrous acid or their salts, nitrogen dioxide, aldehydes such as benzaldehyde (if the target compound is an aromatic carboxylic acid or an aromatic carboxylic acid anhydride, etc.) Is mentioned. When these components are present in the system, the reaction may be accelerated. The usage-amount of the said component is about 0.001-3 mol with respect to 1 mol of said nitrogen atom containing cyclic compound catalysts.

  The reaction in the present invention includes all reactions in which the nitrogen atom-containing cyclic compound exhibits a catalytic action. The details of these reactions are described in the above-mentioned WO 03/28884 pamphlet and WO 03/55600 pamphlet. A typical reaction in which the nitrogen atom-containing cyclic compound exhibits a catalytic action is a reaction between a compound (A) capable of generating a radical and a radical scavenging compound (B). (A) A compound capable of generating radicals and (B) a radical scavenging compound are reacted to give an addition or substitution reaction product of the compound (A) and the compound (B) or a derivative thereof (oxidation reaction product) Products, cyclization reaction products, dehydration reaction products, decarboxylation reaction products, rearrangement reaction products, isomerization reaction products, and the like.

[Compound capable of generating radical (A)]
The compound (A) capable of generating a radical is not particularly limited as long as it is a compound capable of generating a stable radical. As a typical example, the compound (A1) has a carbon-hydrogen bond adjacent to a heteroatom. A heteroatom-containing compound, (A2) a compound having a carbon-heteroatom double bond, (A3) a compound having a methine carbon atom, (A4) a compound having a carbon-hydrogen bond adjacent to the unsaturated bond, (A5) Non-aromatic cyclic hydrocarbons, (A6) conjugated compounds, (A7) amines, (A8) aromatic compounds, (A9) linear alkanes, and (A10) olefins can be mentioned. These compounds may have various substituents as long as the reaction is not inhibited. The compound (A) capable of generating a radical functions as a radical donating compound.

  As the heteroatom-containing compound (A1) having a carbon-hydrogen bond at the adjacent position of the heteroatom, (A1-1) primary or secondary alcohol or primary or secondary thiol, (A1-2) An ether having a carbon-hydrogen bond adjacent to an oxygen atom or a sulfide having a carbon-hydrogen bond adjacent to a sulfur atom, (A1-3) an acetal having a carbon-hydrogen bond adjacent to an oxygen atom (also a hemiacetal) Thioacetal (including thiohemiacetal) having a carbon-hydrogen bond at a position adjacent to a sulfur atom.

The primary or secondary alcohol in (A1-1) includes a wide range of alcohols. The alcohol may be monovalent, divalent or polyhydric alcohol. Typical primary alcohols include 1-30 carbon atoms (preferably 1-20, more preferably 1-20, such as methanol, ethanol, 1-propanol, 1-butanol, 1-hexanol, ethylene glycol, pentaerythritol. 15) about saturated or unsaturated aliphatic primary alcohols; saturated or unsaturated alicyclic primary alcohols such as cyclohexylmethyl alcohol; aromatic primary alcohols such as benzyl alcohol and cinnamon alcohol; 2-hydroxymethyl And heterocyclic alcohols such as pyridine. Typical secondary alcohols include 3 to 30 carbon atoms (preferably 3 to 20, more preferably 3 to 20 carbon atoms, such as vicinal diols such as 2-propanol, s-butyl alcohol, and 1,2-propanediol). 15) about a saturated or unsaturated aliphatic secondary alcohol; an aliphatic hydrocarbon group and an alicyclic hydrocarbon (such as a cycloalkyl group) are bonded to a carbon atom to which a hydroxyl group is bonded, such as 1-cyclohexylethanol Secondary alcohols such as cyclohexanol, 2-adamantanol, 2-adamantanol having 1 to 4 hydroxyl groups at the bridgehead position, and 2-adamantanol having an oxo group in the adamantane ring (3 to 20 members ( Preferably a saturated or unsaturated alicyclic secondary alkyl of about 3 to 15 members, more preferably 5 to 15 members, especially 5 to 8 members) Chromatography (including bridged cyclic secondary alcohols) yl; 1-phenyl-aromatic secondary alcohols such as ethanol; 1- the like (2-pyridyl) heterocyclic secondary alcohols such as ethanol. Further, representative alcohols include 1-adamantane methanol, α-methyl-2-tricyclo [5.2.1.0 ^2,6 ] decane methanol, α-methyl-1-norbornane methanol, α-methyl-2. -Alcohols having a bridged ring hydrocarbon group such as norbornene-1-methanol (compounds having a bridged ring hydrocarbon group bonded to a carbon atom to which a hydroxyl group is bonded) are also included.

  Examples of the primary or secondary thiol in (A1-1) include thiols corresponding to the primary or secondary alcohol.

  Examples of the ether having a carbon-hydrogen bond at the position adjacent to the oxygen atom in (A1-2) include aliphatic ethers such as dimethyl ether, diethyl ether, dipropyl ether, dibutyl ether, diallyl ether, and methyl vinyl ether; , Aromatic ethers such as dibenzyl ether and phenyl benzyl ether; cyclic ethers such as dihydrofuran, tetrahydrofuran, pyran, dihydropyran, tetrahydropyran, morpholine, chroman and isochroman (with aromatic or non-aromatic rings condensed) May be included).

  Examples of the sulfide having a carbon-hydrogen bond at a position adjacent to a sulfur atom in (A1-2) include a sulfide corresponding to an ether having a carbon-hydrogen bond at a position adjacent to the oxygen atom.

  Examples of the acetal having a carbon-hydrogen bond at the position adjacent to the oxygen atom in (A1-3) include an acetal derived from an aldehyde and an alcohol or an acid anhydride, and the acetal includes a cyclic acetal and a non-acetal. Cyclic acetals are included. Examples of the aldehyde include aliphatic aldehydes such as formaldehyde, acetaldehyde, propionaldehyde, butyraldehyde, isobutyraldehyde, hexanal and decanal; alicyclic aldehydes such as cyclopentanecarbaldehyde and cyclohexanecarbaldehyde; and aromatics such as benzaldehyde and phenylacetaldehyde. And group aldehydes. Examples of the alcohol include monohydric alcohols such as methanol, ethanol, 1-propanol, 1-butanol, and benzyl alcohol; dihydric alcohols such as ethylene glycol, propylene glycol, and 1,3-propanediol. . As typical acetals, 1,3-dioxolane compounds such as 1,3-dioxolane and 2-methyl-1,3-dioxolane; 1,3-dioxane compounds such as 2-methyl-1,3-dioxane; acetaldehyde dimethyl Examples thereof include dialkyl acetal compounds such as acetal.

  Examples of the thioacetal having a carbon-hydrogen bond at the position adjacent to the sulfur atom in (A1-3) include thioacetals corresponding to the acetal having a carbon-hydrogen bond at the position adjacent to the oxygen atom.

  Examples of the compound (A2) having a carbon-heteroatom double bond include (A2-1) carbonyl group-containing compounds, (A2-2) thiocarbonyl group-containing compounds, (A2-3) imines, and the like. The carbonyl group-containing compound (A2-1) includes ketones and aldehydes, for example, chains of acetone, methyl ethyl ketone, methyl isobutyl ketone, methyl isopropenyl ketone, methyl cyclohexyl ketone, acetophenone, methyl (2-pyridyl) ketone, and the like. Ketones; cyclic ketones such as cyclopentanone, cyclohexanone, isophorone, cyclododecanone, 2-adamantanone; 1, 1, such as biacetyl (2,3-butanedione), 2,3-pentanedione, bibenzoyl (benzyl) 2-dicarbonyl compounds (α-diketones, etc.); α-keto alcohols such as acetoin, benzoin; acetaldehyde, propionaldehyde, butanal, hexanal, succinaldehyde, glutaraldehyde, adipine aldehyde Aliphatic aldehydes; Cyclohexylaldehyde, citral, citronellal and other alicyclic aldehydes; Benzaldehyde, carboxybenzaldehyde, cinnamaldehyde, salicylaldehyde, anisaldehyde, phthalaldehyde, isophthalaldehyde, terephthalaldehyde and other aromatic aldehydes; furfural, nicotinaldehyde And heterocyclic aldehydes.

  Examples of the thiocarbonyl group-containing compound (A2-2) include thiocarbonyl group-containing compounds corresponding to the carbonyl group-containing compound (A2-1).

  The imines (A2-3) include the carbonyl group-containing compound (A2-1) and ammonia or amines (for example, methylamine, ethylamine, propylamine, butylamine, hexylamine, benzylamine, cyclohexylamine, aniline, etc. And imines (including oximes and hydrazones) derived from hydroxylamines such as hydroxylamine and O-methylhydroxylamine; hydrazines such as hydrazine, methylhydrazine and phenylhydrazine.

  The compound (A3) having a methine carbon atom includes (A3-1) a cyclic compound containing a methine group (that is, a methine carbon-hydrogen bond) as a structural unit of the ring, and (A3-2) a chain having a methine carbon atom. Like compounds.

  The cyclic compound (A3-1) includes (A3-1a) a bridged cyclic compound having at least one methine group, and (A3-1b) a non-aromatic cyclic compound (alicyclic ring) having a hydrocarbon group bonded to the ring. Formula hydrocarbon etc.). The bridged cyclic compound includes a compound in which two rings share two carbon atoms, for example, a hydrogenated product of condensed polycyclic aromatic hydrocarbons.

Examples of the bridged cyclic compound (A3-1a) include decalin, bicyclo [2.2.2] octane, bicyclo [3.3.3] undecane, bornane, bornylene, norbornane, norbornene, and tricyclo [5.2. .1.0 ^3,8] decane, tricyclo [4.2.1.1 ^{2, 5]} decane, exo-tricyclo [5.2.1.0 ^{2, 6]} decane, end tricyclo [5.2. 1.0 ^2,6 ] decane, endotricyclo [5.2.2.0 ^2,6 ] undecane, adamantane, 1-adamantanol, 1,3-dimethyladamantane, 1-carboxyadamantane, 1-methoxycarbonyladamantane 2-4 cyclic bridged cyclic hydrocarbons or bridged heterocyclic compounds such as 1-nitroadamantane and quinuclidine, and derivatives thereof. These bridged cyclic compounds have a methine carbon atom at the bridge head position (corresponding to the bonding site when two rings share two atoms).

  Examples of the non-aromatic cyclic compound (A3-1b) having a hydrocarbon group bonded to the ring include 1-methylcyclopentane, 1-methylcyclohexane, limonene, menten, menthol, carbomenton, menthone, and the like. Examples thereof include about 3 to 15-membered alicyclic hydrocarbons having about 20 (preferably 1 to 10) hydrocarbon groups (for example, alkyl groups) bonded to the ring and derivatives thereof. The non-aromatic cyclic compound (A3-1b) in which a hydrocarbon group is bonded to a ring has a methine carbon atom at the bonding site between the ring and the hydrocarbon group.

  Examples of the chain compound (A3-2) having a methine carbon atom include chain hydrocarbons having a tertiary carbon atom such as isobutane, isopentane, isohexane, 3-methylpentane, 2,3-dimethylbutane, 2 Examples thereof include aliphatic hydrocarbons having about 4 to 20 carbon atoms (preferably 4 to 10), such as methyl hexane, 3-methyl hexane, 3,4-dimethyl hexane, and 3-methyl octane, and derivatives thereof.

  As the compound (A4) having a carbon-hydrogen bond at the adjacent position of the unsaturated bond, (A4-1) an aromatic compound having a methyl group or a methylene group at the adjacent position (so-called benzyl position) of the aromatic ring, (A4-2) Non-aromatic compounds having a methyl group or a methylene group at an adjacent position of an unsaturated bond (for example, a carbon-carbon unsaturated bond, a carbon-oxygen double bond, etc.), and the like.

  In the aromatic compound (A4-1), the aromatic ring may be either an aromatic hydrocarbon ring or an aromatic heterocyclic ring. Aromatic hydrocarbon rings include benzene rings and condensed carbocycles (for example, condensed carbocycles in which 2 to 10 4 to 7 membered carbocycles such as naphthalene, azulene, indacene, anthracene, phenanthrene, triphenylene, and pyrene are condensed) ) Etc. are included. As the aromatic heterocycle, for example, a heterocycle containing an oxygen atom as a hetero atom (for example, a 5-membered ring such as furan, oxazole or isoxazole, a 6-membered ring such as 4-oxo-4H-pyran, benzofuran, iso Benzofuran, condensed rings such as 4-oxo-4H-chromene, etc.), heterocycles containing a sulfur atom as a hetero atom (for example, 5-membered rings such as thiophene, thiazole, isothiazole, thiadiazole, 4-oxo-4H-thiopyran, etc. 6-membered rings, condensed rings such as benzothiophene, etc.), heterocycles containing nitrogen atoms as heteroatoms (for example, 5-membered rings such as pyrrole, pyrazole, imidazole, triazole, etc., 6-membered rings such as pyridine, pyridazine, pyrimidine, pyrazine, etc. Ring, indole, quinoline, acridine, naphthyridine, quinazoline, Other condensed rings down), and the like.

  The methylene group adjacent to the aromatic ring may be a methylene group constituting a non-aromatic ring condensed with the aromatic ring. In the above (A4-1), both a methyl group and a methylene group may be present at a position adjacent to the aromatic ring.

  Examples of the aromatic compound having a methyl group adjacent to the aromatic ring include aromatic hydrocarbons having about 1 to 6 methyl groups substituted on the aromatic ring (for example, toluene, xylene, 1-ethyl- 4-methylbenzene, 1-ethyl-3-methylbenzene, 1-isopropyl-4-methylbenzene, 1-t-butyl-4-methylbenzene, 1-methoxy-4-methylbenzene, mesitylene, pseudocumene, durene, methyl Naphthalene, dimethylnaphthalene, methylanthracene, 4,4'-dimethylbiphenyl, tolualdehyde, dimethylbenzaldehyde, trimethylbenzaldehyde, toluic acid, trimethylbenzoic acid, dimethylbenzoic acid, etc.), about 1 to 6 methyl groups in the heterocyclic ring Substituted heterocyclic compounds (eg 2-methylfuran, 3-methyl Lan, 3-methylthiophene, 2-methylpyridine, 3-methylpyridine, 4-methylpyridine, 2,4-dimethylpyridine, 2,4,6-trimethylpyridine, 4-methylindole, 2-methylquinoline, 3- Examples thereof include methylquinoline and the like.

  Examples of the aromatic compound having a methylene group adjacent to the aromatic ring include aromatic hydrocarbons having an alkyl group having 2 or more carbon atoms or a substituted alkyl group (for example, ethylbenzene, propylbenzene, 1,4- Diethylbenzene, diphenylmethane, etc.), an aromatic heterocyclic compound having an alkyl group having 2 or more carbon atoms or a substituted alkyl group (for example, 2-ethylfuran, 3-propylthiophene, 4-ethylpyridine, 4-butylquinoline, etc.), A compound in which a non-aromatic ring is condensed to an aromatic ring, and a compound having a methylene group at a position adjacent to the aromatic ring among the non-aromatic rings (dihydronaphthalene, indene, indane, tetralin, fluorene Acenaphthene, phenalene, indanone, xanthene, etc.).

  Non-aromatic compounds (A4-2) having a methyl group or methylene group adjacent to the unsaturated bond include, for example, (A4-2a) a chain unsaturated carbonization having a methyl group or methylene group at the so-called allylic position. Examples of the hydrogen compound include a compound having a methyl group or a methylene group adjacent to the (A4-2b) carbonyl group.

  Examples of the chain unsaturated hydrocarbons (A4-2a) include propylene, 1-butene, 2-butene, 1-pentene, 1-hexene, 2-hexene, 1,5-hexadiene, 1-octene, Examples thereof include chain unsaturated hydrocarbons having about 3 to 20 carbon atoms such as 3-octene and undecatriene. Examples of the compound (A4-2b) include ketones (eg, chain ketones such as acetone, methyl ethyl ketone, 3-pentanone, and acetophenone; cyclic ketones such as cyclohexanone), carboxylic acids or derivatives thereof (eg, acetic acid, propion). Acid, butanoic acid, pentanoic acid, hexanoic acid, heptanoic acid, phenylacetic acid, malonic acid, succinic acid, glutaric acid, and esters thereof).

  The non-aromatic cyclic hydrocarbon (A5) includes (A5-1) cycloalkanes and (A5-2) cycloalkenes.

  Examples of the cycloalkane (A5-1) include compounds having a 3- to 30-membered cycloalkane ring, such as cyclopentane, cyclohexane, cyclooctane, cyclodecane, cyclododecane, and derivatives thereof. Preferred cycloalkane rings include 5-30 membered, especially 5-20 membered cycloalkane rings.

  Cycloalkenes (A5-2) include compounds having a 3- to 30-membered cycloalkene ring, such as cyclopentene, cyclohexene, cyclopentadiene, 1,3-cyclohexadiene, 1,5-cyclooctadiene, etc. And cycloalkatrienes such as cyclooctatriene, and derivatives thereof. Preferred cycloalkenes include compounds having 3 to 20 membered rings, especially 3 to 12 membered rings.

  The conjugated compound (A6) includes conjugated dienes (A6-1), α, β-unsaturated nitriles (A6-2), α, β-unsaturated carboxylic acids or derivatives thereof (for example, esters, amides, acids Anhydride, etc.) (A6-3).

  Examples of the conjugated dienes (A6-1) include butadiene and isoprene. The conjugated dienes (A6-1) include compounds in which a double bond and a triple bond are conjugated, such as vinyl acetylene.

  Examples of the α, β-unsaturated nitrile (A6-2) include (meth) acrylonitrile. As α, β-unsaturated carboxylic acid or its derivative (A6-3), (meth) acrylic acid; (meth) acrylic acid methyl, (meth) acrylic acid ethyl, (meth) acrylic acid isopropyl, (meth) acrylic Examples include (meth) acrylic acid esters such as butyl acid and (meth) acrylic acid-2-hydroxyethyl; (meth) acrylamide derivatives such as (meth) acrylamide and N-methylol (meth) acrylamide.

  Examples of the amines (A7) include primary or secondary amines such as methylamine, ethylamine, propylamine, butylamine, dimethylamine, diethylamine, dibutylamine, ethylenediamine, 1,4-butanediamine, hydroxylamine, Aliphatic amines such as ethanolamine; cycloaliphatic amines such as cyclopentylamine and cyclohexylamine; aromatic amines such as benzylamine and toluidine; cyclic amines such as pyrrolidine, piperidine, piperazine and indoline (aromatic or non-aromatic) A ring may be condensed) and the like.

  Examples of the aromatic hydrocarbon (A8) include at least benzene, naphthalene, acenaphthylene, phenanthrene, anthracene, naphthacene, acanththrylene, triphenylene, pyrene, chrysene, naphthacene, picene, perylene, pentacene, coronene, pyranthrene, ovalene, and the like. An aromatic compound having one benzene ring, preferably a condensed polycyclic aromatic compound in which a plurality of (for example, 2 to 10) benzene rings are condensed. These aromatic hydrocarbons may have one or more substituents. Further, the benzene ring may be condensed with a non-aromatic carbocycle, an aromatic heterocycle, or a non-aromatic heterocycle.

  Examples of the linear alkane (A9) include about 1 to 30 carbon atoms such as methane, ethane, propane, butane, pentane, hexane, heptane, octane, nonane, decane, dodecane, tetradecane, and hexadecane (preferably carbon). A linear alkane having a number of about 1 to 20).

  The olefins (A10) may be any of α-olefins and internal olefins which may have a substituent (for example, the above-mentioned exemplified substituents such as a hydroxyl group and an acyloxy group), and diene. Olefins having a plurality of carbon-carbon double bonds such as are also included. For example, as olefins (A10), ethylene, propylene, 1-butene, 2-butene, isobutene, 1-pentene, 2-pentene, 1-hexene, 2-hexene, 2,3-dimethyl-2-butene, 3 -Hexene, 3-hexen-1-ol, 1-octene, 2-octene, 3-octene, 4-octene, 1-decene, 1-dodecene, styrene, vinyltoluene, α-methylstyrene, 3-vinylpyridine, Examples include chain olefins such as 3-vinylthiophene; cyclic olefins such as cyclopentene, cyclohexene, limonene, 1-p-mentene, 3-p-mentene, and 2-bornene.

  The above-mentioned compounds capable of generating radicals may be used alone, or two or more of the same or different ones may be used in combination. When these compounds are used in combination of two or more, particularly two or more different compounds, for example, when reacting with an oxygen atom-containing gas such as oxygen, one substrate is a co-reactant (co-oxidant) of the other substrate. Etc.) and the reaction rate may be significantly improved.

[Radical scavenging compound (B)]
As the radical scavenging compound (B), any compound capable of reacting with a radical to form a stable compound may be used, and representative compounds thereof include (B1) an unsaturated compound and (B2) a methine carbon atom. Compounds, (B3) heteroatom-containing compounds, and (B4) oxygen atom-containing reactants (oxygen atom-containing gases, etc.). These compounds may be used alone or in combination of two or more. These compounds may have various substituents as long as the reaction is not inhibited.

  The unsaturated compound (B1) includes a wide range of compounds having an unsaturated bond. Examples of such compounds include (B1-1) unsaturated compounds having an electron withdrawing group adjacent to the carbon-carbon unsaturated bond [active unsaturated compounds such as active olefins (electron-deficient olefins)], (B1- 2) Compound having carbon-carbon triple bond, (B1-3) Compound having aromatic ring, (B1-4) Ketenes, (B1-5) Isocyanate or thiocyanate compound, (B1-6) Inactive olefin Etc. can be exemplified.

  Examples of the active unsaturated compound (B1-1) include methyl (meth) acrylate, ethyl (meth) acrylate, isopropyl (meth) acrylate, phenyl (meth) acrylate, methyl crotonate, and 2-pentene. Α, β-unsaturated esters such as methyl acrylate, methyl cinnamate, dimethyl maleate, diethyl maleate, dimethyl fumarate, diethyl fumarate, methyl 3-cyanoacrylate and ethyl 3-cyanoacrylate; vinyl methyl ketone Α, β-unsaturated ketones such as vinylethylketone; α, β-unsaturated aldehydes such as propenal and crotonaldehyde; α, β-unsaturated nitriles such as acrylonitrile and methacrylonitrile; and (meth) acrylic Α, β-unsaturated carboxylic acids such as acid and crotonic acid; α, β- such as (meth) acrylamide Unsaturated carboxylic acid amides; α, β-unsaturated imines such as N- (2-propenylidene) methylamine and N- (2-butenylidene) methylamine; styrene, vinyltoluene, α-methylstyrene, β-methyl Compounds having an aryl group bonded to the position adjacent to the carbon-carbon unsaturated bond such as styrene derivatives such as styrene; conjugated dienes such as butadiene, isoprene, 2-chlorobutadiene, 2-ethylbutadiene, vinylacetylene, cyclopentadiene derivatives (Including compounds in which a double bond and a triple bond are conjugated).

  Examples of the compound (B1-2) having a carbon-carbon triple bond include methylacetylene and 1-butyne. The compound having an aromatic ring (B1-3) includes a compound having an aromatic carbon ring such as a benzene ring or a naphthalene ring; a compound having an aromatic heterocyclic ring such as a pyrrole ring, a furan ring or a thiophene ring Is included. Ketenes (B1-4) include ketene, 2-methylketene, and the like. The isocyanate or thiocyanate compound (B1-5) includes methyl isocyanate, ethyl isocyanate, phenyl isocyanate, methyl thiocyanate, ethyl thiocyanate, phenyl thiocyanate, and the like.

  The inactive olefin (B1-6) may be either an α-olefin or an internal olefin, and also includes an olefin having a plurality of carbon-carbon bonds such as a diene. Representative examples of the non-active olefin (B1-6) include, for example, ethylene, propylene, 1-butene, 2-butene, isobutene, 1-hexene, 2-hexene, 3-hexene, 1-octene and 2-octene. , Chain olefins (alkenes) such as 3-octene, 4-octene, 1-decene and 1-dodecene; cyclic olefins (cycloalkenes) such as cyclopentene, cyclohexene, cyclooctene, cyclodecene and cyclododecene It is done.

  Examples of the compound (B2) having a methine carbon atom include the compounds exemplified as the above (A3). In the reaction, the same compound may be used as the compound (A3) and the compound (B2).

  The heteroatom-containing compound (B3) includes (B3-1) a compound having a sulfur atom, (B3-2) a compound having a nitrogen atom, (B3-3) a compound having a phosphorus atom, (B3-4) oxygen Compounds having atoms are included. Examples of the compound (B3-1) having a sulfur atom include sulfides and thiols. Examples of the compound (B3-2) having a nitrogen atom include amines. Examples of the compound having a phosphorus atom (B3-3) include phosphites. Examples of the compound having an oxygen atom (B3-4) include N-oxides.

  The oxygen atom-containing reactant (B4) includes an oxygen atom-containing gas, nitric acid or nitrous acid, or a salt thereof (hereinafter sometimes referred to as nitric acid). Examples of the oxygen atom-containing gas include those having a boiling point (or sublimation point) of 45 ° C. or lower. Typical examples thereof include (B4-1) oxygen, (B4-2) carbon monoxide, ( B4-3) nitrogen oxides, (B4-4) sulfur oxides, and the like. These oxygen atom-containing reactants can be used alone or in combination of two or more.

  Oxygen (B4-1) may be either molecular oxygen or active oxygen. The molecular oxygen is not particularly limited, and pure oxygen may be used, or oxygen or air diluted with an inert gas such as nitrogen, helium, argon, or carbon dioxide may be used. In many cases, molecular oxygen is used as oxygen.

  As carbon monoxide (B4-2), pure carbon monoxide may be used, or one diluted with an inert gas may be used. When carbon monoxide and oxygen are used in combination, a carboxylic acid can be obtained in a high yield by reaction with the compound (A).

The nitrogen oxide (B4-3) includes a compound represented by N _x O _y (wherein x represents 1 or 2, y represents an integer of 1 to 6). In this compound, when x is 1, y is usually an integer of 1 to 3, and when x is 2, y is usually an integer of 1 to 6.

Typical examples of nitrogen oxides include N ₂ O, NO, N ₂ O ₃ , NO ₂ , N ₂ O ₄ , N ₂ O ₅ , NO ₃ and N ₂ O ₆ . These nitrogen oxides can be used alone or in combination of two or more. Nitrogen oxide may be pure or a mixture containing nitrogen oxide as a main component. As a mixture containing nitrogen oxide as a main component, for example, exhaust gas of a nitric acid oxidation process can be used.

Preferred nitrogen oxides include NO, N ₂ O ₃ , NO ₂ , N ₂ O _{5 and the} like. N ₂ O ₃ can be easily obtained by reaction of dinitrogen oxide (N ₂ O) and / or nitric oxide (NO) with oxygen. More specifically, it can be prepared by introducing nitrogen monoxide (or dinitrogen oxide) and oxygen into a cooled reactor to produce blue liquid N ₂ O ₃ . Therefore, the reaction of the present invention may be performed by introducing dinitrogen oxide (N ₂ O) and / or nitrogen monoxide (NO) and oxygen into the reaction system without generating N ₂ O ₃ in advance. . Nitrogen oxides can be used with oxygen. For example, the yield of a product (for example, a nitro compound) can be further improved by using NO ₂ and oxygen in combination.

The sulfur oxide (B4-4) includes a compound represented by S _p O _q (wherein p is 1 or 2, q is an integer of 1 to 7). In this compound, when p is 1, q is usually an integer of 1 to 4, and when p is 2, q is usually 3 or 7.

Typical examples of the sulfur oxide include SO, S ₂ O ₃ , SO ₂ , SO ₃ , S ₂ O ₇ and SO ₄ . These sulfur oxides can be used alone or in combination of two or more. Note that fuming sulfuric acid containing sulfur trioxide may be used as sulfur trioxide.

Preferred sulfur oxides include sulfur oxides containing as a main component at least one selected from sulfur dioxide (SO ₂ ) and sulfur trioxide (SO ₃ ). Sulfur oxides can also be used with oxygen. For example, when sulfur dioxide (SO ₂ ) and oxygen are used in combination, the corresponding sulfonic acid can be obtained in a high yield by reaction with the compound (A).

  As salts of nitric acid and nitrous acid, alkali metal salts such as sodium salt and potassium salt; alkaline earth metal salts such as magnesium salt, calcium salt and barium salt; other metal salts such as silver salt, aluminum salt and zinc salt Etc. Preferable salts include alkali metal salts of nitric acid or nitrous acid.

  Nitric acid may be supplied to the reaction system as it is, but can be supplied to the reaction system in the form of a solution such as an aqueous solution. Moreover, these can also be produced | generated in a reaction system and used for reaction.

  The reaction of the compound (A) capable of generating a radical and the radical scavenging compound (B) is carried out in the presence or absence of a solvent. Examples of the solvent include organic acids such as acetic acid and propionic acid; nitriles such as acetonitrile, propionitrile and benzonitrile; amides such as formamide, acetamide, dimethylformamide (DMF) and dimethylacetamide; hexane, octane and the like Aliphatic hydrocarbons; halogenated hydrocarbons such as chloroform, dichloromethane, dichloroethane, carbon tetrachloride, chlorobenzene, trifluoromethylbenzene; nitro compounds such as nitrobenzene, nitromethane, nitroethane; esters such as ethyl acetate and butyl acetate; water; These mixed solvents are mentioned. As the solvent, organic acids such as acetic acid, nitriles such as acetonitrile and benzonitrile, halogenated hydrocarbons such as trifluoromethylbenzene, and esters such as ethyl acetate are often used.

  The ratio of the compound (A) capable of generating radicals and the radical scavenging compound (B) can be appropriately selected depending on the type (price, reactivity) and combination of both compounds. For example, the compound (A) may be used in excess (for example, about 2 to 50 mole times) relative to the compound (B), and conversely, the compound (B) is used in excess relative to the compound (A). Also good.

  The reaction temperature can be appropriately selected according to the types of the compound (A) and the compound (B), the type of the target product, and the like, and is, for example, 0 to 300 ° C., preferably 20 to 250 ° C., more preferably 20 to It is about 200 ° C. The reaction can be carried out at normal pressure or under pressure, and is usually about 0.1 to 10 MPa (for example, 0.15 to 8 MPa, particularly 1 to 8 MPa) when the reaction is carried out under pressure. The reaction time can be appropriately selected from the range of about 10 minutes to 48 hours, for example, depending on the reaction temperature and pressure.

  The reaction can be performed by a conventional method such as a batch system, a semi-batch system, or a continuous system. When the nitrogen atom-containing cyclic compound catalyst is sequentially added to the system, the target compound can often be obtained with a higher conversion rate and selectivity.

  According to the method of the present invention, depending on the combination of the compound (A) capable of generating radicals and the radical scavenging compound (B), a product by addition or substitution reaction, for example, a carbon-carbon bond forming reaction product (cup) Ring reaction products, etc.), oxidation reaction products, carboxylation reaction products, nitration reaction products, sulfonation reaction products, etc., or derivatives thereof.

  For example, when the heteroatom-containing compound (A1) having a carbon-hydrogen bond at the adjacent position of the heteroatom is used as the compound (A), the adjacent position of the heteroatom is the unsaturated compound (B1). Addition or substitution reaction generated by binding to an atom forming a saturated bond (for example, a carbon atom), the methine carbon atom of a compound (B2) having a methine carbon atom, or the heteroatom of a heteroatom-containing compound (B3) Product or derivatives thereof.

  In addition, when a compound having a carbon-heteroatom double bond (for example, a carbonyl group-containing compound) (A2) is used as the compound (A), a carbon atom related to the carbon-heteroatom double bond (for example, carbonyl carbon) Atom) and an atom adjacent to the carbon atom are broken, and an atomic group containing the carbon-heteroatom double bond (for example, an acyl group) is converted into the compound (B1), (B2) or (B3 To give an addition or substitution reaction product or a derivative thereof.

  Further, when the compound (A3) having a methine carbon atom is used as the compound (A) capable of generating a radical, the methine carbon atom is the site of the compound (B1), (B2) or (B3). To the corresponding addition or substitution reaction product or derivative thereof.

  Usually, when the unsaturated compound (B1) is used as the radical scavenging compound (B), the addition reaction product is used. When the compound (B2) having a methine carbon atom is used, the substitution reaction product (for example, cup Ring product, etc.).

  Further, when an oxygen atom-containing reactive agent (B4) is used as the radical scavenging compound (B) and reacted with a compound (A) capable of generating radicals, an oxygen atom-containing group corresponding to the type of the oxygen atom-containing reactive agent An organic compound containing (for example, hydroxyl group, oxo group, carboxyl group, nitro group, sulfur acid group, etc.) is produced.

  More specifically, when oxygen (B4-1) is used as the oxygen atom-containing reactant, the oxidation reaction proceeds and a corresponding oxidation product is obtained. For example, when a heteroatom-containing compound (A1) having a carbon-hydrogen bond at the position adjacent to the heteroatom is used as the compound (A), the carbon atom adjacent to the heteroatom is oxidized. For example, a corresponding aldehyde or carboxylic acid is generated from a primary alcohol, and a corresponding ketone or the like is generated from a secondary alcohol. Further, the corresponding hydroxyketone can be obtained from 1,3-diol, and the corresponding carboxylic acid can be obtained from 1,2-diol by oxidative cleavage. Furthermore, the corresponding ester or acid anhydride can be obtained from ether.

  When the compound (A2) having a carbon-heteroatom double bond is used as the compound (A), an oxidation reaction product corresponding to the type of heteroatom is obtained. For example, when a ketone is oxidized, it is cleaved to produce a carboxylic acid or the like, and a dicarboxylic acid such as adipic acid is obtained from a cyclic ketone such as cyclohexanone. Further, when a heteroatom-containing compound (A1) having a carbon-hydrogen bond adjacent to a heteroatom such as a secondary alcohol (for example, benzhydrol) is used as a co-reactant (co-oxidant), Under the conditions, a Bayer-bilger type reaction proceeds, and corresponding lactones can be obtained from cyclic ketones, and corresponding esters can be obtained from chain ketones in good yield. In addition, a corresponding carboxylic acid is produced from aldehydes.

  Further, when the compound (A3) having a methine carbon atom is used as the compound (A), an alcohol derivative having a hydroxyl group introduced into the methine carbon can be obtained in high yield. For example, when a bridged cyclic hydrocarbon (A3-1a) such as adamantane is oxidized, an alcohol derivative having a hydroxyl group introduced at the bridge head position, such as 1-adamantanol, 1,3-adamantanediol, and 1,3 , 5-adamantanetriol can be obtained with high selectivity. From the chain compound (A3-2) having a methine carbon atom such as isobutane, a tertiary alcohol such as t-butanol can be obtained in high yield.

  When the compound (A4) having a carbon-hydrogen bond at the position adjacent to the unsaturated bond is used as the compound (A), the position adjacent to the unsaturated bond is efficiently oxidized to produce alcohol, carboxylic acid, ketone or the like. For example, primary alcohols or carboxylic acids can be obtained in high yield from a compound having a methyl group adjacent to the unsaturated bond. Further, from a compound having a methylene group or a methine group at the position adjacent to the unsaturated bond, a secondary or tertiary alcohol, a ketone or a carboxylic acid can be obtained with high yield depending on the reaction conditions.

  More specifically, from an aromatic compound in which an alkyl group or a lower oxidation group thereof is bonded to an aromatic ring, the aromatic group in which the alkyl group or the lower oxidation group is oxidized and a carboxyl group is bonded to the aromatic ring. A group carboxylic acid is produced. Hereinafter, this reaction will be described.

The aromatic ring includes benzene ring, naphthalene ring, acenaphthylene ring, phenanthrene ring, anthracene ring, pyrene ring and other aromatic carbon rings; furan ring, thiophene ring, pyrrole ring, pyrazole ring, imidazole ring, tetrazole ring, oxazole ring , Isoxazole ring, isothiazole ring, thiazole ring, pyridine ring, 4-oxo-1,4-dihydropyridine ring, 2-oxo-1,2-dihydropyridine ring, pyridazine ring, pyrimidine ring, pyrazine ring, quinoline ring, 4 -Oxo-4H-pyran ring, 2-oxo-2H-pyran ring, benzofuran ring, indole ring, indazole ring, benzotriazole ring, quinazoline ring, phthalazine ring, 1,8-naphthyridine ring, acridine ring, phenazine ring, chromone Oxygen atoms such as rings, sulfur atoms and nitrogen atoms And aromatic heterocyclic ring are exemplified having 1-3 about at least one heteroatom is al selected. These aromatic rings have various substituents (for example, a carboxyl group, a halogen atom, a hydroxyl group, an alkoxy group, an acyloxy group, a substituted oxycarbonyl group, a substituted or unsubstituted amino group, and a nitro group as long as they do not inhibit the reaction. Etc.), and an aromatic ring or a non-aromatic ring may be condensed. Examples of the alkyl group bonded to the aromatic ring include methyl, ethyl, propyl, isopropyl, butyl, isobutyl, s-butyl, pentyl, isopentyl, hexyl, isohexyl, heptyl, octyl, 2-ethylhexyl, and decyl groups. A primary or secondary alkyl group may be mentioned. Among these, C _1-4 alkyl group, particularly a methyl group, an ethyl group, a C _1-3 alkyl group such as isopropyl group.

The low-order oxidation group of the alkyl group means a low-order oxidation group in which the carbon atom at the 1-position is not oxidized to a carboxyl group or an equivalent thereof. For example, hydroxyalkyl group, formyl group, formylalkyl Group, an alkyl group having an oxo group, and the like. Examples of the hydroxyalkyl group include hydroxymethyl, 1-hydroxyethyl, 2-hydroxyethyl, 1-hydroxypropyl, 1-hydroxy-1-methylethyl, 2-hydroxypropyl, 3-hydroxypropyl, and 1-hydroxybutyl groups. Etc. Examples of the formylalkyl group include formylmethyl, 1-formylethyl, 2-formylethyl, 1-formylpropyl group and the like. Examples of the alkyl group having an oxo group include aliphatic acyl groups such as acetyl, propionyl, butyryl, pentanoyl, and hexanoyl groups. Among these, a low-order oxidation group corresponding to a C _1-4 alkyl group (particularly, a C _1-3 alkyl group) is preferable. The alkyl group and its lower oxidation group may have various substituents as long as the reaction is not inhibited.

  Typical examples of aromatic compounds in which an alkyl group or a lower oxidation group thereof is bonded to an aromatic ring include, for example, toluene, ethylbenzene, isopropylbenzene (cumene), n-propylbenzene, o-cresol, and m-cresol. P-cresol, o-toluic acid (2-methylbenzoic acid), m-toluic acid (3-methylbenzoic acid), p-toluic acid (4-methylbenzoic acid), 4-chloro-1-methylbenzene, 2-methoxy-1-methylbenzene, 3-methoxy-1-methylbenzene, 4-methoxy-1-methylbenzene, 4-ethoxy-1-methylbenzene, 4-isopropoxy-1-methylbenzene, 2-acetoxy- 1-methylbenzene, 3-acetoxy-1-methylbenzene, 4-acetoxy-1-methylbenzene, 4-propionylo Ci-1-methylbenzene, 4-methoxycarbonyl-1-methylbenzene, 4-ethoxycarbonyl-1-methylbenzene, 4-amino-1-methylbenzene, 4-dimethylamino-1-methylbenzene, 1-methylnaphthalene 2-methylnaphthalene, methylanthracene, benzyl alcohol, 1-hydroxyethylbenzene, benzaldehyde, acetophenone, propiophenone, o-carboxybenzaldehyde, m-carboxybenzaldehyde, p-carboxybenzaldehyde, o-hydroxybenzaldehyde, m-hydroxybenzaldehyde, p-hydroxybenzaldehyde, o-hydroxybenzyl alcohol, m-hydroxybenzyl alcohol, p-hydroxybenzyl alcohol, 2-methylfuran, 3 Methylfuran, 2-methylthiophene, 3-methylthiophene, 2-methylpyridine (α-picoline), 3-methylpyridine (β-picoline), 4-methylpyridine (γ-picoline), 2-ethylpyridine, 3- Ethylpyridine, 4-ethylpyridine, 3-isopropylpyridine, 4-methylindole, 5-methylindole, 7-methylindole, 2-methylquinoline, 3-methyl-4-pyrone, N-substituted or unsubstituted-3- Compounds in which one alkyl group or one lower-order oxidation group thereof is bonded to an aromatic ring such as methyl-4-pyridone and 2-chloro-4-methylpyridine; o-xylene, m-xylene, p-xylene, 1- Ethyl-4-methylbenzene, 1-ethyl-3-methylbenzene, diisopropylbenzene, xylenol (for example, 2,3-alkyl Silenol, 2,4-xylenol, 3,5-xylenol, etc.), thymol (6-isopropyl-m-cresol), methylbenzaldehyde (tolualdehyde), dimethylbenzoic acid (for example, 2,3-dimethylbenzoic acid, 2, 4-dimethylbenzoic acid, 3,5-dimethylbenzoic acid, etc.), 4,5-dimethylphthalic acid, 4,6-dimethylisophthalic acid, 2,5-dimethylterephthalic acid, 3,4,5,6-tetrachloro -1,2-dimethylbenzene, 3,4,5,6-tetrabromo-1,2-dimethylbenzene, 2,3-dimethylnitrobenzene, 1,5-dimethylnaphthalene, 2,5-dimethylnaphthalene, diisopropylnaphthalene, dimethyl Anthracene, 4,4'-dimethylbiphenyl, 2,3-dimethylpyridine (2,3-lutidine 2,4-dimethylpyridine (2,4-lutidine), 2,5-dimethylpyridine (2,5-lutidine), 3,5-dimethylpyridine (3,5-lutidine), 2,6-dimethylpyridine ( 2,6-lutidine), 2-ethyl-4-methylpyridine, 3,5-dimethyl-4-pyrone, N-substituted or unsubstituted-3,5-dimethyl-4-pyridone, an alkyl group or Compounds in which two low-order oxidation groups are bonded; 1,2,3-trimethylbenzene, 1,2,4-trimethylbenzene (pseudocumene), 1,3,5-trimethylbenzene (mesitylene), 1,2 , 3,5-tetramethylbenzene, 1,2,3,4-tetramethylbenzene, 1,2,4,5-tetramethylbenzene (durene), 1,2,3,4,5,6-hexamethyl benzene Dimethylbenzyl alcohol, dimethylbenzaldehyde, 2,4,5-trimethylbenzoic acid, trimethylanthracene, 2,3,4-trimethylpyridine, 2,3,5-trimethylpyridine, 2,3,6-trimethylpyridine, 2,4 , 6-trimethylpyridine, and the like are compounds in which three or more alkyl groups or lower oxidation groups thereof are bonded to an aromatic ring.

  In the present invention, for example, toluene, ethylbenzene, isopropylbenzene, benzaldehyde, a mixture thereof, benzoic acid; p-xylene, p-isopropyltoluene, p-diisopropylbenzene, p-tolualdehyde, p-toluic acid, p-carboxyl Benzaldehyde, terephthalic acid from these mixtures; m-xylene, m-tolualdehyde, m-carboxybenzaldehyde, isophthalic acid from these mixtures, etc .; phthalic acid from o-xylene; pseudocumene, dimethylbenzaldehyde, dimethylbenzoic acid, Trimellitic acid from these mixtures; durene, trimethylbenzaldehyde, trimethylbenzoic acid, pyromellitic acid from these mixtures; 3-quinolinecarboxylic acid from 3-methylquinoline, etc. Rate well obtained. Nicotinic acid is obtained from β-picoline.

  Further, for example, secondary alcohols or ketones can be obtained from a compound having a methylene group at the adjacent position of the carbon-carbon double bond. In this case, when a cobalt (II) salt of an acid having a pKa of 8.0 or less such as cobalt acetate (II) or cobalt nitrate (II) is used as a cocatalyst, an oxo group is introduced into the carbon atom of the methylene group. A conjugated unsaturated carbonyl compound is obtained in high yield. More specifically, nootkatone can be obtained from Valensen in high yield.

  When a non-aromatic cyclic hydrocarbon (A5) is used as the compound (A), depending on the alcohol, hydroperoxide or ketone in which a hydroxy group, hydroperoxy group or oxo group is introduced into the carbon atom constituting the ring, or the reaction conditions The ring is oxidatively cleaved to produce the corresponding dicarboxylic acid. For example, cyclohexyl alcohol, cyclohexyl peroxide, cyclohexanone or adipic acid can be obtained with good selectivity from cyclohexane by appropriately selecting the conditions. Further, bis (1-hydroxycycloalkyl) peroxide such as bis (1-hydroxycyclohexyl) peroxide can be obtained from cycloalkane such as cyclohexane. Furthermore, by using a strong acid as a cocatalyst, adamantane can be obtained from adamantane with good yield.

  When the conjugated compound (A6) is used as the compound (A), various compounds are generated depending on the structure. For example, alkenediol and the like are produced by oxidation of conjugated dienes. Specifically, when butadiene is oxidized, 2-butene-1,4-diol, 1-butene-3,4-diol and the like are obtained. When α, β-unsaturated nitrile, α, β-unsaturated carboxylic acid or a derivative thereof is oxidized, α, β-unsaturated bond site is selectively oxidized, and the unsaturated bond becomes a single bond, and β A compound in which the position is converted into a formyl group, an acetal group (when reacted in the presence of an alcohol) or an acyloxy group (when reacted in the presence of a carboxylic acid) is obtained. More specifically, for example, when acrylonitrile and methyl acrylate are oxidized in the presence of methanol, methyl 3,3-dimethoxypropionitrile and methyl 3,3-dimethoxypropionate are produced, respectively.

  When amines (A7) are used as compound (A), the corresponding Schiff base, oxime, etc. are produced. When the aromatic compound (A8) is used as the compound (A), a compound having a carbon-hydrogen bond (for example, fluorene or the like) (A4) or the like adjacent to the unsaturated bond is used as a co-reactant (co-oxidant). When they coexist, the corresponding quinones are produced with good yield. In addition, alcohol, ketone, carboxylic acid and the like are generated from linear alkane (A9).

  Furthermore, when an olefin (A10) is used as the compound (A), a corresponding epoxy compound can be obtained. In particular, a co-reactant such as a heteroatom-containing compound (A1) having a carbon-hydrogen bond adjacent to a heteroatom such as a secondary alcohol or a compound (A4) having a carbon-hydrogen bond adjacent to an unsaturated bond When coexisting as a (cooxidant), the epoxidation reaction proceeds under mild conditions, and the corresponding epoxide can be obtained in good yield.

  In the presence of the nitrogen atom-containing cyclic compound catalyst, at least one compound selected from cycloalkane, cycloalkanol and cycloalkanone reacts with oxygen (B4-1) as an oxygen atom-containing reactant and ammonia. The corresponding lactam is produced. More specifically, when at least one compound selected from cyclohexane, cyclohexanol and cyclohexanone is reacted with oxygen and ammonia in the presence of the catalyst, ε-caprolactam is obtained.

  When carbon monoxide (B4-2) and oxygen (B4-1) are used as the oxygen atom-containing reactant, the carboxylation reaction proceeds smoothly and the corresponding carboxylic acid can be obtained in good yield. . For example, when a compound (A3) having a methine carbon atom is used as the compound (A), a carboxyl group is introduced into the methine carbon atom and a compound having a carbon-hydrogen bond adjacent to the unsaturated bond (A4 ), A carboxyl group is introduced into the carbon atom associated with the carbon-hydrogen bond. In addition, from a non-aromatic cyclic hydrocarbon (A5) such as cyclohexane, a carboxylic acid in which a carboxyl group is bonded to a carbon atom constituting the ring is generated.

  When nitrogen oxide (B4-3) is used as the oxygen atom-containing reactant, the nitration reaction proceeds mainly, and the corresponding nitro compound is obtained. For example, when the compound (A3) having a methine carbon atom is used as the compound (A), the compound (A4) having a carbon-hydrogen bond adjacent to the unsaturated bond is used when the methine carbon atom is nitrated. The carbon atom associated with the carbon-hydrogen bond is nitrated. Non-aromatic cyclic hydrocarbons such as cyclohexane (A5) produce the corresponding cyclic nitro compounds in which a nitro group is bonded to the carbon atoms constituting the ring. Furthermore, linear alkanes such as hexane (A9 ), The corresponding nitroalkane is produced. When nitrogen dioxide is used as the oxygen atom-containing reactant, the nitration reaction proceeds efficiently if the substrate is used in an excess amount relative to nitrogen dioxide.

  When a compound having a methyl group (for example, toluene) at the adjacent position (so-called benzyl position) of the aromatic ring is used as the compound (A), a nitro group is introduced into the carbon atom of the methyl group. In some cases, a corresponding aromatic aldehyde in which the methyl group is formylated (for example, benzaldehyde) or a compound in which a nitro group is introduced into an aromatic ring may be generated. Furthermore, when a compound having a methylene group adjacent to the aromatic ring (for example, ethylbenzene) is used as a substrate, a nitro compound (for example, α-nitroethylbenzene) in which the methylene group is nitrated is generated and reacted. Depending on conditions, an oxime compound in which the methylene group is oximed (for example, acetophenone oxime) may be generated.

  When nitric oxide is used as the oxygen atom-containing reactant, a corresponding aldehyde produced by cleavage of the ether bond can be obtained from ether. For example, phthalaldehyde can be obtained from phthalane in high yield. When nitrogen monoxide is used as the oxygen atom-containing reactant, the corresponding cycloalkanone oxime can be obtained from cycloalkane. For example, cyclohexanone oxime is produced from cyclohexane.

  When a chain or cyclic compound having a methylene group is reacted with a nitrogen oxide such as nitric oxide in the presence of the nitrogen atom-containing cyclic compound, halogen (such as chlorine) or a Beckmann rearrangement catalyst, the corresponding amide or lactam Produces. For example, ε-caprolactam is obtained from cyclohexane.

  When the nitric acid is used as the oxygen atom-containing reactant, the nitration reaction proceeds mainly as in the case of using the nitrogen oxide (B4-3), and the corresponding nitro compound is obtained. For example, when a compound (A4) having a carbon-hydrogen bond at a site adjacent to the unsaturated bond is used as a substrate, the carbon atom related to the carbon-hydrogen bond is nitrated. Further, when the compound (A3) having a methine carbon atom is used as a substrate, the methine carbon atom is nitrated. Furthermore, when a non-aromatic cyclic hydrocarbon (A5) is used as a substrate, a nitro group is introduced into a carbon atom constituting the ring, and for example, a corresponding nitrocycloalkane is generated from a cycloalkane such as cyclohexane. . Moreover, in the non-aromatic heterocyclic compound having a carbon-hydrogen bond at the adjacent position of the hetero atom, the carbon atom related to the carbon-hydrogen bond is nitrated, and this is supported from linear alkanes (A9) such as hexane. To produce a nitroalkane. In this reaction, the catalyst and nitric acid react to generate an N-oxy radical, which extracts a hydrogen atom from the substrate to generate a radical, to which nitrogen dioxide generated in the system is added. The corresponding nitro compound is considered to be produced.

  When sulfur oxide (B4-4) is used as the oxygen atom-containing reactant, sulfonation or sulfination reaction proceeds, and the corresponding organic sulfur acid or salt thereof is obtained. For example, when the compound (A3) having a methine carbon atom is used as the compound (A), a compound (A4) having a sulfur-acid group introduced into the methine carbon atom and having a carbon-hydrogen bond adjacent to the unsaturated bond is obtained. When used, a sulfur acid group (such as a sulfonic acid group or a sulfinic acid group) is introduced into the carbon atom associated with the carbon-hydrogen bond. In addition, from a non-aromatic cyclic hydrocarbon (A5) such as cyclohexane, an organic sulfur acid in which a sulfur acid group is bonded to a carbon atom constituting the ring is generated. The produced organic sulfur acid can be obtained by a conventional method, for example, alkali metal hydroxide, alkali metal carbonate, alkali metal bicarbonate, alkaline earth metal hydroxide, alkaline earth in a suitable solvent such as water. By reacting with metal carbonates, amines, thioureas, isothioureas, etc., they can be converted into the corresponding organic sulfur salts.

  Further, in the method of the present invention, by using two or more kinds of compounds (A) capable of generating radicals and radical scavenging compounds (B), substitution or addition reaction occurs sequentially, and one step of complex organic compounds It is possible to obtain in For example, when the unsaturated compound (B1) and oxygen (B4-1) are used as the radical scavenging compound (B) and reacted with the compound (A), among the two carbon atoms that form an unsaturated bond, As described above, a group derived from the compound (A) is bonded to one carbon atom, and an oxygen-derived hydroxyl group can be introduced to the other carbon atom.

  In the method of the present invention, details of the reaction mechanism are not necessarily clear, but an oxidation active species [for example, N-oxy radical (> NO.)] Is generated in the course of the reaction, which is hydrogenated from the compound (A). For example, the compound (A1) has a carbon atom adjacent to the hetero atom, the compound (A2) has a carbon-heteroatom double bond, the compound (A3) has a methine carbon atom, the compound ( In A4), a radical is generated on each carbon atom adjacent to the unsaturated bond, and the radical thus generated reacts with the compound (B) to produce the corresponding substitution or addition reaction product. It is guessed. In addition, the addition or substitution reaction product produced by the above reaction undergoes further dehydration reaction, cyclization reaction, decarboxylation reaction, rearrangement reaction, isomerization reaction, etc. in the reaction system depending on the structure and reaction conditions. Corresponding derivatives can be produced.

  When the organic compound produced by the reaction is a solid, it is usually separated by crystallization or precipitation (including crystallization or precipitation during the reaction step). The solvent used for crystallization and precipitation may be a poor solvent for the target compound, and is appropriately selected from an organic solvent, water, and a mixed solvent thereof according to the type of the target compound. However, the organic compound thus separated is adhering to the nitrogen atom-containing cyclic compound catalyst or a denatured product (decomposition product) of the catalyst, and if this is used as it is in a polymerization reaction, polymerization is inhibited. Or the produced polymer may be colored.

  An important feature of the present invention is that the organic compound thus obtained is subjected to rinsing and / or repulping to obtain a target product having a reduced nitrogen-containing impurity content. The organic compound subjected to rinsing and / or repulping is not particularly limited as long as it is the reaction product and is a solid compound at room temperature. For example, carboxylic acid, acid anhydride, ester, lactone, sulfonic acid, Any of amide, lactam, nitrile, ketone, aldehyde, alcohol, ether, hydrocarbon, amine, nitro compound, oxime and the like may be used. Among these, polyvalent carboxylic acids that are required to have a low content of nitrogen-containing impurities for use, especially fragrances such as terephthalic acid, orthophthalic acid (phthalic acid), isophthalic acid, trimellitic acid, and pyromellitic acid Group polycarboxylic acids are preferred.

As the solvent used for the rinsing treatment and the repulping treatment, a solvent in which the target compound is hardly soluble and the nitrogen atom-containing cyclic compound catalyst or a modified product (decomposed product) thereof is easily soluble is preferable. Examples of such solvents include organic acids such as carboxylic acids such as formic acid, acetic acid, propionic acid and butyric acid; halogenated hydrocarbons such as methylene chloride, chlorobenzene and dichlorobenzene; chain ethers such as dimethoxyethane; tetrahydrofuran and dioxane. Cyclic ethers such as acetone, ketones such as methyl ethyl ketone; esters such as methyl acetate, ethyl acetate and butyl acetate; nitro compounds such as nitromethane; nitriles such as acetonitrile and benzonitrile; carbonates such as dimethyl carbonate, ethylene carbonate and propylene carbonate; Examples include alcohols such as methanol, ethanol, butanol, and ethylene glycol; mixed solvents thereof. Among these, organic acids are preferable, and C _1-4 aliphatic carboxylic acids are particularly preferable. In addition, when the reaction solvent is carboxylic acid, it is preferable to use the same carboxylic acid as the reaction solvent as a rinse solvent and a repulp solvent.

  Either the rinsing process or the repulping process may be performed, or both processes may be used in combination. In addition, each process can be performed a plurality of times. Although the usage-amount of a solvent is not specifically limited, Usually, it is 10-10000 weight part with respect to 100 weight part of target compounds, Preferably it is about 100-3000 weight part. The temperature at the time of performing a rinse process and a repulp process is 0-150 degreeC, for example, Preferably it is about 30-120 degreeC. The rinsing time and repulping time can be appropriately set according to the type and amount of solvent used.

  The organic compound that has been subjected to the rinsing treatment and / or the repulping treatment may be further subjected to purification (for example, recrystallization and the like) as necessary.

  According to the present invention, nitrogen-containing impurities (particularly components derived from a nitrogen atom-containing cyclic compound catalyst) can be efficiently removed from a solid organic compound, and a compound having an extremely small amount of nitrogen can be obtained. Therefore, the present invention is particularly useful as a method for producing an organic compound obtained by a reaction using a cyclic acylurea compound having a cyclic acylurea skeleton represented by the above formula (II) rich in nitrogen as a catalyst. The organic compound thus obtained can be used as a raw material for polymers (eg, polyester, polyamide, polyimide, etc.), an intermediate raw material for fine chemicals, and the like.

  EXAMPLES Hereinafter, although this invention is demonstrated in detail based on an Example, this invention is not limited by these Examples. The nitrogen content in the crystal was analyzed by the Kjeldahl decomposition method (indophenol method).

Example 1
Reaction is performed in a gas-liquid continuous reaction system using a reactor equipped with a reflux condenser, stirrer, mass flow, raw material supply line, gas introduction line, reaction liquid extraction line, exhaust gas line, pressure gauge, and pressure regulator. It was. In the reactor, 10% by weight of p-xylene, 1.0% by weight of N-hydroxynaphthalimide (N-hydroxy-1,8-naphthalenedicarboxylic acid imide), 0.23% by weight of manganese (II) acetate tetrahydrate %, Acetic acid mixed solution containing cobalt acetate (II) tetrahydrate 0.09% by weight, and air from the bottom of the reactor so that the oxygen concentration in the exhaust gas line is 3 to 6%. The reaction was continuously carried out, the reaction was carried out under conditions of a reaction temperature of 170 ° C., a reaction pressure of 2 MPa, and a residence time of 2 hours, and the reaction solution was continuously discharged out of the system. The obtained reaction solution was cooled to room temperature, and the precipitated crystals were filtered. 10 times the amount of acetic acid obtained was added to the crystal and stirred at 60 ° C. for 1 hour to repulp the crystal. The crystals were filtered at a temperature of 60 ° C. and dried to obtain terephthalic acid. The nitrogen content of the crystals was 36 ppm by weight. The nitrogen content of the crystals before repulping was 101 ppm by weight.

Example 2
The procedure of Example 1 was repeated except that 0.86% by weight of N, N ′, N ″ -triacetoxyisocyanuric acid was used instead of 1.0% by weight of N-hydroxynaphthalimide. The crystals obtained had a nitrogen content of 62 ppm by weight, and the nitrogen content of the crystals before repulping was 138 ppm by weight.

Example 3
The same as Example 1 except that 1.2% by weight of N-acetoxysinaphthalimide (N-acetoxy-1,8-naphthalenedicarboxylic imide) was used instead of 1.0% by weight of N-hydroxynaphthalimide. Operation was performed to obtain crystals of terephthalic acid. The nitrogen content of the obtained crystal was 74 ppm by weight. The nitrogen content of the crystals before repulping was 152 ppm by weight.

Example 4
The same procedure as in Example 1 was performed except that 0.50% by weight of N, N ′, N ″ -trihydroxyisocyanuric acid was used instead of 1.0% by weight of N-hydroxynaphthalimide. The obtained crystals had a nitrogen content of 140 ppm by weight, and the nitrogen content of the crystals before repulping was 190 ppm by weight.

Claims (7)

The following formula (I) or (II)

[Wherein, X represents an oxygen atom or an —OR group (R represents a hydrogen atom or a protecting group for a hydroxyl group). G represents a carbon atom or a nitrogen atom. n represents 1 or 2, and when n is 2, two Gs may be the same or different.]
In the method of producing an organic compound by reacting a substrate in the presence of a cyclic imide-based or cyclic acylurea-based compound catalyst having a cyclic imide skeleton or a cyclic acylurea skeleton represented by the formula, the generated organic compound is rinsed and / or repulped. A method for producing an organic compound characterized in that a target product having a reduced nitrogen-containing impurity content is obtained. The cyclic imide compound is represented by the following formula (1)

[Wherein, X represents an oxygen atom or an —OR group (R represents a hydrogen atom or a protecting group for a hydroxyl group). R ¹ , R ² , R ³ , R ⁴ , R ⁵ and R ⁶ are the same or different and are a hydrogen atom, halogen atom, alkyl group, aryl group, cycloalkyl group, hydroxyl group, alkoxy group, carboxyl group, substituted An oxycarbonyl group, an acyl group or an acyloxy group, wherein at least two of R ¹ , R ² , R ³ , R ⁴ , R ⁵ and R ⁶ are bonded to each other to form a double bond, or aromatic or non-aromatic Sex rings may be formed. ^{Two of} R ¹ , R ² , R ³ , R ⁴ , R ⁵ , R ⁶ , or at least two of R ¹ , R ² , R ³ , R ⁴ , R ⁵ and R ⁶ are bonded together. In the case of a heavy bond or an aromatic or non-aromatic ring, the following formula (a)

(Wherein X is the same as above)
Or one or more cyclic imide skeletons represented by
The method for producing an organic compound according to claim 1, wherein the compound is represented by the formula: The cyclic acyl urea compound is represented by the following formula (2)

(In the formula, R represents a hydrogen atom or a protecting group for a hydroxyl group. R ^a and R ^d may be the same or different and may be protected with a hydrogen atom, an alkyl group, an aryl group, a cycloalkyl group or a protecting group. A good hydroxyl group, a carboxyl group which may be protected by a protecting group, or an acyl group, and R ^b and R ^c are the same or different and are a hydrogen atom, a halogen atom, an alkyl group, an aryl group, a cycloalkyl group, A hydroxyl group, an alkoxy group, a carboxyl group, a substituted oxycarbonyl group, an acyl group or an acyloxy group, at least two of R ^a , R ^b , R ^c and R ^d are bonded to each other to form a ring in the formula A double bond or an aromatic or non-aromatic ring may be formed together with an atom, and R ^b and R ^c may be combined to form an oxo group)
The method for producing an organic compound according to claim 1, wherein the compound is represented by the formula:   An organic compound produced by at least one reaction selected from the group consisting of an oxidation reaction, a nitration reaction, a carboxylation reaction, a sulfonation oxidation reaction, and a carbon-carbon bond formation reaction, as an organic compound subjected to rinsing and / or repulping The method for producing an organic compound according to any one of claims 1 to 3.   The method for producing an organic compound according to any one of claims 1 to 4, wherein the organic compound to be subjected to rinsing and / or repulping is a polyvalent carboxylic acid.   The method for producing an organic compound according to any one of claims 1 to 4, wherein the organic compound to be subjected to rinsing and / or repulping is an aromatic polycarboxylic acid. The method for producing an organic compound according to any one of claims 1 to 6, wherein the solvent used for the rinsing and / or repulping treatment is an organic acid.