JP2006224987A - Ptp package - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To provide a PTP package which has no die marks on the front and rear surfaces, and is flattened in the PTP package comprising a PTP sheet and an aluminum foil. <P>SOLUTION: The PTP sheet and the aluminum foil are bonded by using a PTP molding machine having a sealing die on which a cushioning material is installed excepting a pocket receiving hole section, and a flat heating plate without grooves. Thus, the PTP package which has no die marks on the front and rear surfaces and is flattened is obtained. <P>COPYRIGHT: (C)2006,JPO&NCIPI

Description

  The present invention relates to a PTP package, and specifically to a flat PTP package without dice.

  In the field of pharmaceutical packaging, PTP (Press Through Pack) packaging is generally used for packaging solid agents such as tablets and capsules. In PTP packaging, a sheet made of vinyl chloride, polyolefin, or the like is formed to form a large number of recesses, and medicines and various foods such as tablets and capsules are stored in the recesses, and then covered with a cover made of aluminum foil or paper. The package has a structure in which the content can break and take out the aluminum foil when the molded part of the sheet is pressed.

  In such a package, after filling tablets or capsules into the recesses of the plastic sheet (hereinafter referred to as “PTP sheet”) formed in the numerous recesses, the PTP sheet and the aluminum foil are bonded by heat, A PTP package is manufactured. When bonding the PTP sheet and aluminum foil, in order to prevent tearing of the aluminum foil at the time of bonding, so-called pinholes, a groove of a lattice, a so-called dice (angle 40 to 50 °, It is necessary to provide a pitch of 0.5 to 1.5 mm and a depth of about 0.1 to 1 mm. Therefore, a large number of dies are usually observed on the aluminum foil of the PTP package.

  In recent years, drug information management is an important task in hospitals due to frequent medication errors. In addition, in order to shorten the patient waiting time for drugs, automation of dispensing etc. is also being studied. Therefore, in order to manage drug information, it is considered that a bar code or a two-dimensional code is attached to the aluminum foil surface (the aluminum foil surface opposite to the PTP sheet and the aluminum foil bonding surface) of the PTP package. . It is also considered that an explanatory note is put on the aluminum foil surface of the PTP package. However, as described above, there are almost all dice on the aluminum foil surface of the PTP package. When a bar code or a two-dimensional code is attached to an aluminum foil surface having such a die, the bar code or the two-dimensional code may not be read due to irregular reflection of light or may be read erroneously. In addition, detailed explanations may become very difficult to read due to the dice.

  On the other hand, when manufacturing a PTP package, if a hot plate without a die is used and the PTP sheet and the aluminum foil are bonded, the air remaining between the PTP sheet and the aluminum foil is usually discharged through the groove of the die. Inability to do so causes a so-called air pocket on the PTP package.

Patent Document 1 describes that a PTP sheet without an uneven surface can be produced using a mirror roll without an uneven surface. Patent Document 2 describes that a PTP sheet having a small uneven surface was produced. However, both are related to PTP sheets, and there is no description about a PTP package that is flat on an aluminum foil surface without a die and that does not generate pinholes or air pockets.
JP 2001-219964 A JP 2004-224300 A

  When a bar code or two-dimensional code is attached to the aluminum foil surface of the PTP package, the dice are present on the aluminum foil surface, causing irregular reflection of light, etc. If the bar code or two-dimensional code cannot be read or read incorrectly There is a possibility that. In addition, detailed explanations on the aluminum foil surface may be very difficult to read depending on the die. Therefore, there has been a demand for a so-called flattened PTP package that has no dice on the aluminum foil surface of the PTP package and that does not cause pinholes or air accumulation on the PTP package.

  Therefore, as a result of intensive studies to solve the above problems, the inventors have devised a method for manufacturing a PTP package, whereby the aluminum foil surface of the PTP package is flattened, and a pinhole is formed on the PTP package. And a PTP package that does not have so-called dice and does not cause air retention.

That is, the present invention
(1) In a PTP package comprising a PTP sheet and an aluminum foil, there is no die on the front and back surfaces of the package, and the PTP package is characterized in that the front and back surfaces are flattened,
(2) The PTP package according to the above (1), wherein there are no pinholes and air pockets on the front and back surfaces of the PTP package,
(3) The PTP package according to (1) or (2), wherein the material of the PTP sheet is one or more selected from polyvinyl chloride, polypropylene, polyvinylidene chloride, polyethylene, polychlorotrifluoroethylene, and polyester. ,
(4) The PTP package according to (3), wherein the material of the PTP sheet is polyvinyl chloride,
(5) 1) Seal mold in which cushioning material is installed on the seal mold excluding the pocket receiving hole,
2) Using a PTP molding machine having a flat heating plate without grooves, a PTP sheet and an aluminum foil are bonded to each other, a method for producing a PTP package,
(6) The production method according to the above (5), wherein the material of the buffer material is a fluororesin,
(7) The production method according to the above (5), wherein the thickness of the buffer material is 0.1 to 2.0 mm,
(8) The manufacturing method according to the above (5), wherein the temperature of the heating plate during bonding is 100 to 300 ° C.
(9) The production method according to the above (5), wherein the adhesion pressure during adhesion is 0.01 to 0.2 MPa,
(10) The production method according to the above (5), wherein the adhesion time is 0.1 to 30 seconds,
(11) 1) Seal mold in which a cushioning material is installed on the seal mold excluding the pocket receiving hole,
2) Using a PTP molding machine having a flat heating plate without grooves, the temperature of the heating plate during bonding is 100 to 300 ° C., the bonding pressure is 0.01 to 0.2 MPa, and the bonding time is 0.1 to 30. A method for producing a PTP package, wherein the sheet and the aluminum foil of the PTP package are bonded according to the conditions of seconds,
It is about.

  The PTP package of the present invention is a PTP package in which the aluminum foil surface is flattened, so-called dice does not exist, and even if a barcode or a two-dimensional code is attached to the aluminum foil surface of the package, A PTP package that can read codes and the like, can be read even if fine characters are attached to the package, and does not cause pinholes or air pockets on the PTP package can be manufactured.

  The PTP package of the present invention relates to a so-called flattened PTP package in which no dice are present on the front and back surfaces and a method for producing the same. That is, after filling tablets or capsules into the recesses of the PTP sheet formed in the recesses, the PTP sheet and aluminum foil, the seal mold with the cushioning material installed on the seal mold excluding the pocket receiving holes, and no grooves By a PTP packaging machine having a flat heating plate, it is possible to produce a flattened PTP package by bonding with heat. In addition, the front and back surfaces of the PTP package refer to the surface where the PTP sheet and the aluminum foil are in contact and the back surface thereof.

  The PTP sheet of the PTP package used in the present invention may be a plastic sheet usually used in a PTP package. Specific examples include polyvinyl chloride, polypropylene, polyvinylidene chloride, polyester, and polychlorotrifluoroethylene, with polyvinyl chloride being preferred. Polyvinyl chloride has good moldability, strong durability, and low cost. The thickness of this sheet is generally 150 to 600 μm, preferably 200 to 400 μm, more preferably 250 to 300 μm. If it is thicker than this thickness, there is a possibility that the contents cannot be taken out, and if it is thin, sufficient durability as a PTP package may not be maintained. Here, the PTP sheet formed in the recess is usually referred to as a blister bottom material, and has transparency, so that the contents are highly visible.

  What is necessary is just to use the aluminum foil normally used with a PTP package body as the aluminum foil of the PTP package body used for this invention. The thickness of the aluminum foil is generally 10 to 50 μm, preferably 15 to 45 μm, more preferably 20 to 40 μm as a total thickness including the adhesive. If it is thicker than this thickness, there is a risk that the aluminum foil will not break when the contents are taken out, and the contents may be deformed or cracked. If it is thin, sufficient durability as a PTP package may not be maintained. There is sex. When the aluminum foil is used, the aluminum foil itself has a barrier property and can be printed. If the PTP sheet side is pressed, the aluminum foil can be easily broken and opened by the contents, and the contents can be taken out.

  The PTP package of the present invention can be produced by a normal method for producing a PTP package. That is, as shown in FIG. 1, a PTP sheet and an aluminum foil are formed by sandwiching a PTP sheet and aluminum foil formed in a recess between a sealing mold and a heating plate of a PTP packaging machine, and pressing the sealing mold and the heating plate. Can be bonded to produce the package.

  In order to manufacture a so-called flattened PTP package having no dice, it is necessary that the dice are not present on the heating plate in the PTP packaging machine. However, as described above, in this case, there is a possibility that pinholes and air pockets are generated between the PTP sheet and the aluminum foil on the surface (contact surface between the PTP sheet and the aluminum foil) of the PTP package. Therefore, in order to manufacture a flattened PTP package without pinholes and air pockets and without dies, as shown in FIG. It is necessary to place a PTP sheet and aluminum foil on it. Accordingly, when the aluminum foil and the PTP sheet are bonded, air accumulated between the PTP sheet and the aluminum foil can be discharged through the buffer material. By the above manufacturing method, a flat PTP package without a die and a PTP package that does not cause pinholes and air accumulation between the PTP sheet and the aluminum foil can be manufactured.

  The buffer material is generally a heat-resistant polymer resin, preferably a fluororesin. More preferably, it is a Teflon (registered trademark) resin. Specifically, it is a plate made of Teflon (registered trademark) resin. By using this Teflon (registered trademark) resin as a cushioning material, a flat PTP package without die holes and free of pinholes and air pockets can be produced. Further, the buffer material itself is not likely to be melted or damaged by heat.

  The thickness of the buffer material may be a thickness that allows air accumulated between the PTP sheet and the aluminum foil to pass through the buffer material when the PTP sheet and the aluminum foil are bonded with the heating plate and the seal mold. Specifically, it is 0.1 to 2 mm, preferably 0.5 to 1.5 mm, and more preferably 0.8 to 1.2 mm. If it is thinner than this thickness, air cannot pass through and there is a risk of pinholes and air pools. On the other hand, if it is thicker than this thickness, there is a possibility that adhesion cannot be sufficiently achieved.

  When bonding a PTP sheet and aluminum foil, the temperature of the heating plate of a PTP packaging machine should just be a temperature which can adhere | attach a PTP sheet and aluminum foil. Specifically, it is 100-300 degreeC, Preferably it is 120-280 degreeC, More preferably, it is 130-250 degreeC. If it is higher than this temperature, the PTP sheet may melt more than necessary, and the sheet itself may be damaged. On the other hand, if it is lower than this temperature, the PTP sheet and the aluminum foil cannot be sufficiently bonded, and the contents may leak from the PTP package.

  The bonding pressure between the heating plate and the sealing mold when bonding the PTP sheet and the aluminum foil may be a pressure that can bond the PTP sheet and the aluminum foil. Specifically, the sealing pressure is 0.01 to 0.2 MPa, preferably 0.02 to 0.1 MPa, and more preferably 0.03 to 0.08 MPa. If it is higher than this pressure, the PTP sheet and aluminum foil may adhere to and adhere to the heating plate and the seal mold. On the other hand, if the pressure is lower than this, the PTP sheet and the aluminum foil cannot be sufficiently bonded, and the contents may leak from the PTP package.

  The bonding time between the PTP sheet and the aluminum foil may be a time that allows the PTP sheet and the aluminum foil to be bonded. Specifically, it is 0.1 to 30 seconds, preferably 0.5 to 20 seconds, and more preferably 1 to 10 seconds. If it is shorter than this time, the PTP sheet and the aluminum foil cannot be sufficiently bonded, and the contents may leak from the PTP package. On the other hand, if it is longer than this time, the PTP sheet or the aluminum foil may adhere to the heating plate or the seal mold.

  As conditions for bonding the PTP sheet and the aluminum foil, the temperature of the heating plate is generally 100 to 300 ° C., the bonding pressure is 0.01 to 0.2 MPa, the bonding time is 0.1 to 30 seconds, preferably the heating plate The temperature is 120 to 280 ° C., the adhesion pressure is 0.02 to 0.1 MPa, the adhesion time is 0.5 to 20 seconds, more preferably the heating plate temperature is 130 to 250 ° C., and the adhesion pressure is 0.03 to 0. 0.08 MPa, adhesion time is 1 to 10 seconds.

  Various characters and figures can be printed on the surface of the aluminum foil of the PTP package. For example, various fine characters can be printed in addition to barcodes and two-dimensional codes. In the case of the PTP package of the present invention, there is no die on the aluminum foil surface of the package, and it is flattened. When reading a barcode or a two-dimensional code, there is no irregular reflection of light, and there is a risk of erroneous reading. Absent.

  It is also possible to manufacture a so-called book sheet type PTP package in which a paper package is sandwiched between the PTP package of the present invention. When manufacturing this book sheet type PTP package, a PTP sheet and an aluminum foil are put into a paper package in a book sheet, and are bonded from above the paper with a sealing mold and a heating plate. This book sheet type PTP package can also be used for a PTP package printed with a day of the week called a calendar pack.

  The PTP package of the present invention can be manufactured with a normal PTP packaging machine provided with a seal mold and a heating plate. If there is a PTP sheet molded in the recess that can hold tablets, etc., the PTP packaging body (semi-automatic PTP packaging machine, manufactured by Daiwa Kasei Kogyo Co., Ltd.) can bond the PTP sheet and aluminum foil. Can be manufactured. A commercially available drum type or flat plate type PTP packaging machine (for example, FBP-M1 manufactured by CKD Corporation) can also be used.

  When packaging a large amount of tablets and capsules with a PTP packaging machine, the accessory equipment of the PTP machine includes tablet / capsule supply device, capsule direction control device, PTP sheet and aluminum foil supply device, stamping device, Usually, a half-cut or perforated device, a sheet punching device, etc. are attached, and specifically, there is FBP-M1 type manufactured by CKD Corporation. For the tablet / capsule supply device, the PTP sheet and the aluminum foil supply device, an automatic supply or automatic sheet connection device can be provided as an option for the purpose of improving workability and saving labor.

  In addition, for quality assurance, devices added to the PTP packaging machine include a device for removing foreign matter (dust, hair, etc.) adhering to the PTP packaging, a tablet breakage detection device using a photoelectric tube, and a cracked chipping foreign material due to image processing. A detection device or the like is used.

  The PTP line for mass production of PTP package is composed of PTP machine, counting / stacking machine, pillow packaging machine, box packing machine, cardboard case packing machine, etc., and can mass-produce the PTP package of the present invention. .

EXAMPLES Examples and test examples will be described below to specifically explain the present invention, but the present invention is not limited to these examples.
Example 1
(Production method)
The PTP sheet and aluminum foil were bonded under the following sealing conditions with a PTP packaging machine (sealing machine, trimming machine, manufactured by Daiwa Kasei Kogyo Co., Ltd.). The PTP sheet used was a No. 4 capsule PTP7P × 12 sheet (polyvinyl chloride, manufactured by Sumitomo Bakelite Co., Ltd.), and the aluminum foil used was a vinyl chloride (PVC) aluminum foil (plain fabric, manufactured by Nippon Metal Co., Ltd.). . Further, a 1 mm-thick fluororesin cushioning material (Teflon (registered trademark) resin, manufactured by Nitto Denko (Shanghai Songjiang) Co., Ltd.) was installed in a portion other than the concave portion of the seal mold.

Sealing conditions • Heating plate: Flat iron plate • Adhesion temperature: 160 ° C
・ Adhesion time: 2 seconds ・ Adhesion pressure: 0.05 MPa

(Experimental result)
As shown in FIG. 3, it was possible to produce a flattened PTP package in which no dice exist on the entire surface of the front and back aluminum foils in the PTP package. Further, no pinholes or air pockets were generated between the PTP sheet on the surface of the PTP package and the aluminum foil.

(Comparative Example 1)
(Production method)
The manufacturing method is the same as in Example 1 except that a fluororesin cushioning material (Teflon (registered trademark) resin, manufactured by Nitto Denko (Shanghai Songjiang) Co., Ltd.) is not installed in any part other than the recess of the seal mold. is there.
(Experimental result)
Although no dice were present on the entire surface of the front and back aluminum foils in the PTP package, air pockets and pinholes were generated between the PTP sheet and the aluminum foil on the front surface.
When a PTP package is manufactured without a cushioning material, air leakage between the PTP sheet and the aluminum foil is not alleviated, and air accumulates in the portion that should be sealed, and when the sheet size is cut out, the outside air is removed from the air reservoir portion. May intrude and make it very difficult to ensure the stability of the contents. Further, pinholes may be generated by strongly pressing a metal heating plate.

(Reference Example 1)
(Production method)
Except that no cushioning material is installed in a portion other than the concave portion of the seal mold and a heating plate containing dice is used as the heating plate, it is the same as in Example 1.
(Experimental result)
As shown in FIG. 4, although no pinholes or air pockets were formed between the PTP sheet and the aluminum foil on the surface (contact surface between the PTP sheet and the aluminum foil) of the PTP package, Dice eyes were observed on the aluminum foil.
Test example

An experiment for reading the two-dimensional code on the back surface of the PTP package of Example 1 and Reference Example 1 was performed. In addition, "the back surface in a PTP package" means the opposite surface of the surface which affixed the aluminum foil and the PTP sheet.
(Test method)
By the method of Example 1 and Reference Example 1, the surface opposite to the aluminum foil surface on which the two-dimensional code was printed was adhered to the PTP sheet to produce a PTP package. Next, a two-dimensional code printed on the back surface of the PTP package was read using a barcode reader (manufactured by Keyence Corporation), and an experiment was performed.
(Test results)
The two-dimensional barcode of the PTP package of Example 1 was able to be read 10 times (100%) in 10 reading experiments, whereas it was 10 times for the PTP package of Reference Example 1. In the reading experiment, it was possible to read only 5 times (50%). From this result, it was revealed that the two-dimensional code printed on the PTP package of Example 1 was significantly easier to read than Reference Example 1.

  Not only can a barcode or a two-dimensional code be attached to the aluminum foil surface of the PTP package of the present invention, but also an explanation can be described, which is useful in that a medicinal error can be prevented.

Manufacturing schematic diagram of PTP package with dice Production schematic diagram of flattened PTP package without die A photograph of the surface of a PTP package manufactured with a heating plate without a die, with a cushioning material on the seal mold A photograph of the surface of a PTP package manufactured with a heating plate with a die without a cushioning material on the seal mold

Claims (11)

A PTP package comprising a PTP sheet and an aluminum foil, wherein there are no dice on the front and back surfaces of the package, and the front and back surfaces are flattened. 2. The PTP package according to claim 1, wherein there are no pinholes and air pockets on the front and back surfaces of the PTP package. The PTP package according to claim 1 or 2, wherein the material of the PTP sheet is one or more selected from polyvinyl chloride, polypropylene, polyvinylidene chloride, polyethylene, polychlorotrifluoroethylene, and polyester. The PTP package according to claim 3, wherein the material of the PTP sheet is polyvinyl chloride. 1) Seal mold with cushioning material on the seal mold excluding the pocket receiving hole,
2) A method for producing a PTP package, wherein a PTP sheet and an aluminum foil are bonded using a PTP packaging machine having a flat heating plate without grooves. The manufacturing method according to claim 5, wherein the material of the buffer material is a fluororesin. The manufacturing method according to claim 5, wherein the thickness of the buffer material is 0.1 to 2.0 mm. The manufacturing method according to claim 5, wherein the temperature of the heating plate at the time of bonding is 100 to 300 ° C. 6. The production method according to claim 5, wherein the adhesion pressure at the time of adhesion is 0.01 to 0.2 MPa. The production method according to claim 5, wherein the adhesion time is 0.1 to 30 seconds. 1) Seal mold with cushioning material on the seal mold excluding the pocket receiving hole,
2) Using a PTP packaging machine having a flat heating plate without grooves, the temperature of the heating plate during bonding is 100 to 300 ° C., the bonding pressure is 0.01 to 0.2 MPa, and the bonding time is 0.1 to 30. A method for producing a PTP package, comprising bonding a sheet of a PTP package and an aluminum foil according to a second condition.

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