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被測定成分を含む被検体における前記被測定成分の測定を行う測定用デバイスにおいて、測定試料中の異物を除去できるプレフィルタ部、測定試料中の成分を分離するためのカラム部、測定試料中の成分の光検出を行うための検出部から構成されており、大きさが４００ｃｍ２以下であることを特徴とするヘモグロビン類の測定用デバイス。
In the measuring device for performing measurement of the component to be measured in a subject comprising the components to be measured, pre-filter unit capable of removing foreign matters in the measurement sample, the column portion for separating components in the measurement sample, the measurement sample A device for measuring hemoglobin, comprising a detection unit for performing light detection of components and having a size of 400 cm2or less .
請求項１記載のヘモグロビン類の測定用デバイスにおいて、測定試料中の異物を除去できるプレフィルタ部、測定試料中の成分を分離するためのカチオン交換基を有するカラム部、測定試料中の成分の吸光度検出を行うための検出部の群の内、少なくとも１つ、または、複数の部位が、ユニット形式に構成されていることを特徴とするヘモグロビン類の測定用デバイス。
2. The device for measuring hemoglobin according to claim 1, wherein a prefilter part capable of removing foreign substances in the measurement sample, a column part having a cation exchange group for separating the components in the measurement sample, and the absorbance of the components in the measurement sample A device for measuring hemoglobin, wherein at least one or a plurality of parts of a group of detection units for performing detection are configured in a unit form.
請求項１〜２のいずれか１項に記載のヘモグロビン類の測定用デバイスに、少なくともカラムの前流路にエア抜き構造が施されていることを特徴とするヘモグロビン類の測定用デバイス。
The hemoglobin measuring device according to any one of claims 1 to 2, wherein an air vent structure is provided at least in a front channel of the column.
請求項１〜３のいずれか１項に記載のヘモグロビン類の測定用デバイスにおいて、前記検出部のセル部が、直線状に形成された流路からなり、前記セル部を、吸光度測定用の光線の光軸が前記直線状に形成された流路の流れ方向になるように、かつ、前記直線状に形成された流路内への前記光線の入射角及び出射角が０°であるように吸光度測定装置に接続可能であることを特徴とするヘモグロビン類の測定用デバイス。
The device for measuring hemoglobin according to any one of claims 1 to 3, wherein the cell portion of the detection unit is formed of a linear channel, and the cell portion is a light beam for measuring absorbance. So that the optical axis is in the flow direction of the linearly formed flow path, and the incident angle and the outgoing angle of the light beam into the linearly formed flow path are 0 ° A device for measuring hemoglobin, which is connectable to an absorbance measuring apparatus.
請求項１〜４のいずれか１項に記載のヘモグロビン類の測定用デバイスにおいて、吸光度測定装置に接続し、検体のない状態で測定した吸光度測定波長における光線透過率が、同一の光路長及び吸光度測定波長で空気を測定した場合の光線透過率の５０％以上であることを特徴とするヘモグロビン類の測定用デバイス。
In measuring devices of hemoglobin according to claim 1, connected to the absorbance measuring apparatus, the light transmittance at an absorbance measurement wavelength measured in the absence of analyte, the same optical path length and A device for measuring hemoglobin, which is 50% or more of light transmittance when air is measured at an absorbance measurement wavelength.
請求項１〜５のいずれか１項に記載のヘモグロビン類の測定用デバイスにおいて、セル部は、流入部及び／又は流出部において接続用流路とコの字状又はＬ字状に接続されていることを特徴とするヘモグロビン類の測定用デバイス。
In measuring devices of hemoglobin according to any one of claims 1 to 5, cell unit is connected to the shape or L-shape of the connecting channel and co in the inlet and / or outlet section A device for measuring hemoglobin, characterized by comprising:
請求項１〜６のいずれか１項に記載のヘモグロビン類の測定用デバイスにおいて、プレフィルタ部、カラム部、セル部、流路部からなる群の内、一つまたは複数部位の表面が、生体成分吸着抑制の表面処理方法が施されていることを特徴とするヘモグロビン類の測定用デバイス。
In measuring devices of hemoglobin according to any one of claims 1 to 6, the pre-filtering unit, column unit, cell unit, among the group consisting of the flow path portion, the surface of one or more sites, A device for measuring hemoglobin, which is subjected to a surface treatment method for suppressing adsorption of biological components.ヘモグロビン類の測定方法において、トリブロモ酢酸イオン、トリクロロ酢酸イオン、チオシアン酸イオン、ヨウ化物イオン、過塩素酸イオン、ジクロロ酢酸イオン、硝酸イオン、臭化物イオン、バリウムイオン、セシウムイオン及びグアニジンイオンからなる群より選ばれる少なくとも一種であるカオトロピックイオンと０．００１％〜０．１％アジ化物イオンを含有し、かつ、ｐＨ４．０〜６．８で緩衝能を持つ無機酸、有機酸及び/またはこれらの塩を含む基板に流す液と、請求項１〜７のいずれか１項に記載のヘモグロビン類の測定用デバイスとを用いることを特徴とするヘモグロビン類の測定方法。
In the method of hemoglobin such, tribromoacetic acid ion, trichloroacetate ion, thiocyanate ion, iodide ion, perchlorate ion, dichloroacetate ion, the group consisting of nitrate ions, bromide ions, barium ions, cesium ions and guanidinium ions An inorganic acid, an organic acid and / or these containing at least one selected from chaotropic ions and 0.001% to 0.1% azide ions and having a buffer capacity at pH 4.0 to 6.8 a liquid to be supplied to the substrate comprising a salt, the method for measuring hemoglobin, which comprises using ameasuringdevice hemoglobin according to any one of claims 1-7.
JP2005003127A2005-01-072005-01-07
Device for measuring μTAS of hemoglobins
ActiveJP5054894B2
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