JP2006160729A - New acetylene compound and method for producing the same - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To provide a method for easily producing an acetylene alcohol having a comparatively large molecular weight and a complicated structure. <P>SOLUTION: The acetylene compound is represented by general formula (1) (wherein, R<SP>1</SP>is a 4-10C monovalent hydrocarbon wherein the carbon bonding to a silicon atom is a tertiary carbon; R<SP>2</SP>and R<SP>3</SP>are each a 1-4C alkyl group or a monovalent group including a fluoroalkyl group represented by Rf-Q-; Rf is a 3-100C perfluoroalkyl group which may include an ether bond in the chain and may be branched; Q is a 2-10C divalent group which may include nitrogen, oxygen or sulfur in the chain; and n is 0 or 1). The new acetylene compound is useful as a nonionic surfactant, an intermediate for a compound, and a reaction controller of hydrosilylation. <P>COPYRIGHT: (C)2006,JPO&NCIPI

Description

  The present invention relates to a novel acetylene compound and a method for producing the same. In particular, the present invention provides acetylene alcohols having a molecular weight so high that isolation by distillation is difficult.

  The acetylene alcohols are, for example, “Orphine” (trade name of Nissin Chemical Industry Co., Ltd.) 3-methyl-1-butyn-3-ol, 3-methyl-1-pentyn-3-ol 2,5-dimethyl- Various acetylene glycols are commercially available, such as 3-hexyne-2,5-diol and “Surfinol” (trade name of Air Products Co., Ltd.).

  These acetylene alcohols are used as intermediate raw materials for compounds, and are also used as nonionic surfactants such as metal surface treatment agents, low foaming wetting agents, antifoaming agents, and pigment dispersants. It is a very useful compound widely used industrially as a control agent for hydrosilylation reaction utilizing high coordination ability to metal (see Patent Documents 1 to 3).

  In general, acetylene alcohols are produced by reacting ketones with acetylide as shown below.

  That is, in order to produce acetylene alcohol having a certain structure, it is necessary to obtain ketones as precursors. If an attempt is made to produce an acetylene alcohol having a high molecular weight and a complicated structure, the above method will be difficult.

A substance obtained by reacting acetylene alcohol with a fluoroalkyl group-containing chlorosilane is known (see Patent Document 4). However, since the fluorine organosilicon compound does not have an alcoholic hydroxyl group, it is not satisfactory as a control agent.

Japanese Examined Patent Publication No. 44-31476 JP-A-6-329917 JP-A-9-143371 JP 2000-53685 A

  The present invention has been made in view of the above circumstances, and provides a method for easily producing acetylene alcohol having a relatively large molecular weight and a complicated structure.

  As a result of investigations to achieve the above object, the present inventors have completed the present invention by providing a silylated acetylene compound represented by the following general formula.

但し、Ｒ^１は、ケイ素原子と結合する炭素原子が３級炭素である炭素数４〜１０の１価炭化水素基、Ｒ^２、Ｒ^３は炭素数１〜４のアルキル基またはＲｆ−Ｑ−で示されるフロロアルキル基を含む１価の基であり、Ｒｆは炭素数３〜１００のパーフルオロアルキル基で、途中エーテル結合を含んでいてもよく、分岐していても良い。Ｑは炭素数２〜１０の２価の基であって途中に窒素、酸素、イオウを含んでもよい。ｎは０または１である。

R ¹ is a monovalent hydrocarbon group having 4 to 10 carbon atoms in which the carbon atom bonded to the silicon atom is a tertiary carbon, R ² and R ³ are alkyl groups having 1 to 4 carbon atoms or Rf-Q- And Rf is a perfluoroalkyl group having 3 to 100 carbon atoms and may contain an ether bond in the middle or may be branched. Q is a divalent group having 2 to 10 carbon atoms and may contain nitrogen, oxygen, or sulfur in the middle. n is 0 or 1.

  An organosilicon compound represented by the following general formula (A);

（但し、Ｒ^１、Ｒ^２及びＲ^３は前記と同じ基、Ｘはハロゲン原子、ｎは０または１である。）下記のアセチレンアルコール（Ｂ）を反応させて、

(However, R ¹ , R ² and R ³ are the same groups as described above, X is a halogen atom, and n is 0 or 1.) The following acetylene alcohol (B) is reacted,

（Ａ）のＳｉ−Ｘと、（Ｂ）のいずれか一方または両方の水酸基とからＳｉ−Ｏ結合を形成させることを特徴とするシリル化されたアセチレン化合物の製造方法。このとき１級炭素に結合した水酸基が優先的にハロゲン化ケイ素化合物と反応してＳｉ−Ｏ結合を生じ、目的とするアセチレンアルコールを得ることができる。

A method for producing a silylated acetylene compound, wherein a Si—O bond is formed from Si—X of (A) and one or both of the hydroxyl groups of (B). At this time, the hydroxyl group bonded to the primary carbon preferentially reacts with the silicon halide compound to form a Si—O bond, and the target acetylene alcohol can be obtained.

  The novel fluorine-containing acetyl alcohol compound of the present invention is extremely useful as a nonionic surfactant, an intermediate of the compound, and a controller for a curing reaction by hydrosilylation of a polymer.

Hereinafter, the present invention will be described in more detail. In the acetylene compound represented by the above general formula, R ¹ is a monovalent hydrocarbon group having 4 to 10 carbon atoms in which the carbon atom bonded to the silicon atom is a tertiary carbon. Examples of such R ¹ include the following structures.

Here, the carbon atom bonded to the silicon atom of R ¹ is limited to the tertiary carbon because the alkyl group containing the tertiary carbon exemplified above is a bulky substituent. This is because it is known to have an effect of stabilizing the —O bond. In the absence of an alkyl group containing a tertiary carbon, the silylated acetylene compound is unstable and may cause inconvenience such as easy hydrolysis.

R ² and R ³ may be the same or different and each is an alkyl group having 1 to 4 carbon atoms or a monovalent group containing a fluoroalkyl group represented by Rf-Q—, and Rf is 3 to 3 carbon atoms It is a 100 perfluoroalkyl group and may contain an ether bond in the middle or may be branched.

  Specific examples of the alkyl group having 1 to 4 carbon atoms include a methyl group, an ethyl group, an n-propyl group, an isopropyl group, an n-butyl group, an isobutyl group, and a t-butyl group. A methyl group is particularly preferable.

  Preferable examples of Rf include the following.

  Q is a divalent organic group having 1 to 20 carbon atoms. Q is not particularly limited as long as it is a divalent organic group having 1 to 20 carbon atoms, but may be intervened through oxygen, nitrogen, carbonyl group, etc., and examples thereof include the following structures.

− (CH ₂ ) _p −
(However, p = 1-10, particularly preferably 2-4)
_{-CH 2 -O- (CH 2) q} -
(However, q = 1-9, particularly preferably 2-4)

（Ｒ^４およびＲ^５は、それぞれ独立に炭素数１〜９のアルキル基もしくは水素原子である。Ｒ^４およびＲ^５として具体的にはメチル基、エチル基、プロピル基、フェニル基、シクロヘキシルなどが挙げられる）

(R ⁴ and R ⁵ are each independently an alkyl group having 1 to 9 carbon atoms or a hydrogen atom. Specific examples of R ⁴ and R ⁵ include a methyl group, an ethyl group, a propyl group, a phenyl group, and cyclohexyl. Can be mentioned)

  The cetylene compound represented by the above general formula of the present invention is an organosilicon compound (A) represented by the following general formula:

（但し、Ｒ^１、Ｒ^２及びＲ^３は前述の通り、Ｘはハロゲン原子）

(Wherein R ¹ , R ² and R ³ are as described above, X is a halogen atom)

  Acetylene alcohol (B) below

とを反応させると、（Ａ）のＳｉ−Ｘと（Ｂ）の１級炭素に結合した水酸基とからＳｉ−Ｏ結合を形成させることにより製造される。

Is reacted with Si—X in (A) and a hydroxyl group bonded to the primary carbon in (B) to produce a Si—O bond.

  The acetylene alcohol 3-methyl-4-pentyne-1,3-diol of (B) can be produced by reacting 4-hydroxy-2-butaneone with an acetylene Grignard reagent. In addition, in J. Am. Chem. Soc. 1980, 102, 6255-6259. It has two hydroxyl groups, one bonded to the primary carbon and the other to the tertiary carbon.

  The silicon halide compound (A) can be produced by reacting a silicon compound having one substituent and three halogens with a bulky alkyl group Grignard reagent (for example, a t-butyl Grignard reagent). By this method, a silicon compound having one substituent, two halogens and a bulky substituent can be obtained. Further, when a silicon compound having one halogen and three substituents is obtained by introducing a substituent, a reagent with relatively little steric hindrance such as an n-butyl Grignard reagent can be subsequently reacted under selective conditions. .

  Specific examples of the organosilicon compound (A) include the following.

（但し、Ｒｆは前述の通り、ｔ−Ｂｕはターシャリブチル基である。）

(However, Rf is a tertiary butyl group as described above.)

[Production method]
The production of the acetylene compound of the present invention is carried out by mixing the acetylene alcohol (B) and the acid acceptor and introducing the organosilicon compound (A) therein. Examples of the acid acceptor include triethylamine, pyridine, urea, 1,4-diazabicyclo [2.2.2] octane (DABCO), 1,8-diazabicyclo [5.4.7] -7-undecene (DBU), and imidazole. Etc.

  A solvent can also be used during the reaction. As the solvent, toluene, xylene, hexane, octane, isooctane, 1,3-bistrifluoromethylbenzene, DMF, N-methylpyrrolidone and the like are suitable.

  When n = 1 in (A) (monofunctional), the amount used is 1 to 2 moles of acetylene alcohol (B) and 1 to 3 moles of acid acceptor per mole of organosilicon compound (A). To do. The reaction temperature may be 20 to 50 ° C., and the reaction time may be 1 to 40 hours. After completion of the reaction, washing with water is repeated to take out the organic phase, and purification is performed using an appropriate method, whereby the target acetylene alcohol can be obtained.

  Further, when n = 0 in (A) (in the case of bifunctionality), 2 to 4 mol of acetylene alcohol (B) and 2 to 4 mol of acid acceptor are used per 1 mol of the organosilicon compound (A). The reaction temperature may be 20 to 50 ° C., and the reaction time may be 1 to 20 hours. After completion of the reaction, washing with water is repeated to take out the organic phase, and purification is performed using an appropriate method, whereby the target acetylene alcohol can be obtained.

  EXAMPLES Hereinafter, although an Example and a comparative example are shown and this invention is demonstrated concretely, this invention is not restrict | limited to the following Example.

[Example 1]
3-methyl-3,5-dihydroxy-pentyne 5.00 g (0.0439 mol), t-butyldimethylchlorosilane 6.58 g (0.0439 mol), imidazole 7.50 g (0.110 mol), dimethylformamide 10.0 g Was stirred at room temperature for 20 hours. After completion of the reaction, 30 g of diethyl ether was added, washed with 50 g of water three times, and then stripped at 70 ° C./5 mmHg to obtain 7.2 g of product. The product was analyzed by NMR and confirmed to have the following structure.

The ¹ H NMR spectrum of this compound is shown in FIG. The results were as follows.
¹ H NMR spectrum (CDCl ₃ )
δ0.05 (Si—C H ₂ , 6H, d)
δ 0.84 ((C H ₃ ) ₃ C-Si, 9H, s)
δ1.43 (C H ₃ —C—OH, 3H, s)
_{δ1.63 (-OCH 2 C H 2 -} , 1H, m)
_{δ1.90 (-OCH 2 C H 2 -} , 1H, m) δ2.38 (-C≡C H, 1H, s)
δ 3.83 (—OC H ₂ CH ₂ —, 1H, m)
δ 4.18 (—OC H ₂ CH ₂ —, 1H, m)
δ4.66 (-O H, 1H, s )

The IR spectrum of this compound is shown in FIG. The results were as follows.
Infrared absorption spectrum 3478 cm ⁻¹ (—OH)
3315 cm ⁻¹ (—C≡CH)

[Example 2]
3-methyl-3,5-dihydroxy-pentyne 5.0 g, triethylamine 3.2 g, 1,3-bistrifluoromethylbenzene 20 g, and 10 g of an organosilicon compound having the following structure,

を反応器に仕込み、室温にて１５時間攪拌を行った。反応終了後、反応混合物を水に投入して有機相を取り出し、さらに水洗を３回繰り返した。回収した有機相に少量の無水硫酸ナトリウムを加え、ろ過したのち、１００℃／５ｍｍＨｇにてストリップして溶媒を取り除いた。このようにして１１．３ｇの生成物を得た。この物質をＮＭＲにて分析したところ、主な生成物は下記（Ｃ）の構造であり、少量の副生成物として（Ｄ）が含まれているものであった。

Was stirred at room temperature for 15 hours. After completion of the reaction, the reaction mixture was poured into water, the organic phase was taken out, and further washed with water three times. A small amount of anhydrous sodium sulfate was added to the collected organic phase, filtered, and then stripped at 100 ° C./5 mmHg to remove the solvent. In this way 11.3 g of product was obtained. When this substance was analyzed by NMR, the main product had the following structure (C), and (D) was contained as a small amount of by-products.

The ¹ H NMR spectrum of this compound is shown in FIG. The results were as follows.
¹ H NMR spectrum (CDCl ₃ )
δ 0.82 (Si—C H ₂ , 2H, s)
δ0.99 ((C H ₃ ) ₃ C-Si, 9H, s)
δ 1.53 (C H ₃ —C—OH, 6H, s)
_{δ1.80 (-OCH 2 - C H 2} - CH 2, 2H, m)
_{δ1.80 (-OCH 2 C H 2 -} , 2H, m)
_{δ2.06 (-OCH 2 C H 2 -} , 2H, m) δ2.47 (-C≡C H, 2H, m)
δ3.56 (—OC H ₂ —CH ₂ —CH ₂ , 2H, m)
δ 3.98 (CF—CH ₂ —O, 2H, d)
δ 4.15 (—OC H ₂ CH ₂ —, 2H, m)
δ4.25 (-O H, 2H, m )
δ 4.43 (—OC H ₂ CH ₂ —, 2H, m)

The IR spectrum of this compound is shown in FIG. The results were as follows.
Infrared absorption spectrum 3478 cm ⁻¹ (—OH)
3315 cm ⁻¹ (—C≡CH)
1300-1000cm ^-1 (C-F)

  From the above results, it was confirmed that the product had the structure of the product (C).

Structure of by-product (D)

It is a NMR spectrum figure of the compound concerning the present invention. Example 1 It is IR spectrum figure of the compound concerning this invention. Example 1 It is a NMR spectrum figure of the compound concerning the present invention. (Example 2) It is IR spectrum figure of the compound concerning this invention. (Example 2)

Claims (2)

An acetylene compound represented by the following general formula.

(However, R ¹ is a monovalent hydrocarbon group having 4 to 10 carbon atoms in which the carbon atom bonded to the silicon atom is a tertiary carbon, R ² and R ³ are alkyl groups having 1 to 4 carbon atoms, or Rf-Q. -Is a monovalent group containing a fluoroalkyl group represented by-, Rf is a perfluoroalkyl group having 3 to 100 carbon atoms, may contain an ether bond, or may be branched, Q is carbon. (It is a divalent group of 2 to 10 and may contain nitrogen, oxygen and sulfur in the middle. N is 0 or 1.) An organosilicon compound represented by the following general formula (A);

(However, R ¹ , R ² and R ³ are the same groups as described above, X is a halogen atom, and n is 0 or 1.)
The following acetylene alcohol (B) is reacted,

A method for producing a silylated acetylene compound, wherein a Si—O bond is formed from Si—X of (A) and one or both of the hydroxyl groups of (B).

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