JP2006151957A5 - - Google Patents
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- JP2006151957A5 JP2006151957A5 JP2005309218A JP2005309218A JP2006151957A5 JP 2006151957 A5 JP2006151957 A5 JP 2006151957A5 JP 2005309218 A JP2005309218 A JP 2005309218A JP 2005309218 A JP2005309218 A JP 2005309218A JP 2006151957 A5 JP2006151957 A5 JP 2006151957A5
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- JP
- Japan
- Prior art keywords
- tetrahydro
- benzazepine
- ylidene
- benzoyl
- trifluoromethyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Claims (1)
(2Z)-N-(2-アミノ-2-オキソエチル)-2-{4,4,7-トリフルオロ-1-[4-{[(2R)-2-フルオロプロピル]オキシ}-2-(トリフルオロメチル)ベンゾイル]-1,2,3,4-テトラヒドロ-5H-1-ベンゾアゼピン-5-イリデン}アセトアミド、
(2Z)-N-(2-ヒドロキシエチル)-2-{4,4,7-トリフルオロ-1-[4-{[(2S)-2-フルオロプロピル]オキシ}-2-(トリフルオロメチル)ベンゾイル]-1,2,3,4-テトラヒドロ-5H-1-ベンゾアゼピン-5-イリデン}アセトアミド、
(2Z)-N-(2-ヒドロキシエチル)-2-{4,4,7-トリフルオロ-1-[4-{[(2R)-2-フルオロプロピル]オキシ}-2-(トリフルオロメチル)ベンゾイル]-1,2,3,4-テトラヒドロ-5H-1-ベンゾアゼピン-5-イリデン}アセトアミド、
(2Z)-2-{4,4-ジフルオロ-1-[4-{[(2R)-2-フルオロプロピル]オキシ}-2-(トリフルオロメチル)ベンゾイル]-1,2,3,4-テトラヒドロ-5H-1-ベンゾアゼピン-5-イリデン}-N-[(2S)-2,3-ジヒドロキシプロピル]アセトアミド、
3-[((2Z)-2-{4,4,7-トリフルオロ-1-[4-{[(2R)-2-フルオロプロピル]オキシ}-2-(トリフルオロメチル)ベンゾイル]-1,2,3,4-テトラヒドロ-5H-1-ベンゾアゼピン-5-イリデン}アセチル)アミノ]プロパンアミド、
(2Z)-N-[(2R)-2,3-ジヒドロキシプロピル]-2-{4,4,7-トリフルオロ-1-[4-{[(2R)-2-フルオロプロピル]オキシ}-2-(トリフルオロメチル)ベンゾイル]-1,2,3,4-テトラヒドロ-5H-1-ベンゾアゼピン-5-イリデン}アセトアミド、
(2Z)-N-(2-アミノ-2-オキソエチル)-2-{4,4,7-トリフルオロ-1-[4-{[(2S)-2-フルオロプロピル]オキシ}-2-(トリフルオロメチル)ベンゾイル]-1,2,3,4-テトラヒドロ-5H-1-ベンゾアゼピン-5-イリデン}アセトアミド、
(2Z)-2-{1-[4-(2,2-ジフルオロプロポキシ)-2-(トリフルオロメチル)ベンゾイル]-4,4-ジフルオロ-1,2,3,4-テトラヒドロ-5H-1-ベンゾアゼピン-5-イリデン}-N-(2-ヒドロキシエチル)アセトアミド、
(2Z)-2-{4,4-ジフルオロ-1-[4-{[(2S)-2-フルオロプロピル]オキシ}-2-(トリフルオロメチル)ベンゾイル]-1,2,3,4-テトラヒドロ-5H-1-ベンゾアゼピン-5-イリデン}-N-(2-ヒドロキシエチル)アセトアミド、
(2Z)-2-{4,4-ジフルオロ-1-[4-{[(2R)-2-フルオロプロピル]オキシ}-2-(トリフルオロメチル)ベンゾイル]-1,2,3,4-テトラヒドロ-5H-1-ベンゾアゼピン-5-イリデン}-N-(2-ヒドロキシエチル)アセトアミド、
(2Z)-2-{1-[4-(2,2-ジフルオロプロポキシ)-2-(トリフルオロメチル)ベンゾイル]-4,4,7-トリフルオロ-1,2,3,4-テトラヒドロ-5H-1-ベンゾアゼピン-5-イリデン}-N-(2-ヒドロキシエチル)アセトアミド、
(2Z)-N-[(2R)-2,3-ジヒドロキシプロピル]-2-{4,4,7-トリフルオロ-1-[4-プロポキシ-2-(トリフルオロメチル)ベンゾイル]-1,2,3,4-テトラヒドロ-5H-1-ベンゾアゼピン-5-イリデン}アセトアミド、
(2Z)-2-{4,4-ジフルオロ-1-[4-{[(2S)-2-フルオロプロピル]オキシ}-2-(トリフルオロメチル)ベンゾイル]-1,2,3,4-テトラヒドロ-5H-1-ベンゾアゼピン-5-イリデン}-N-[(2S)-2,3-ジヒドロキシプロピル]アセトアミド、
(2Z)-2-{4,4-ジフルオロ-1-[4-{[(2R)-2-フルオロプロピル]オキシ}-2-(トリフルオロメチル)ベンゾイル]-1,2,3,4-テトラヒドロ-5H-1-ベンゾアゼピン-5-イリデン}-N-[(2R)-2,3-ジヒドロキシプロピル]アセトアミド、
3-[((2Z)-2-{4,4,7-トリフルオロ-1-[4-{[(2S)-2-フルオロプロピル]オキシ}-2-(トリフルオロメチル)ベンゾイル]-1,2,3,4-テトラヒドロ-5H-1-ベンゾアゼピン-5-イリデン}アセチル)アミノ]プロパンアミド、
(2Z)-N-[(2R)-2,3-ジヒドロキシプロピル]-2-{4,4,7-トリフルオロ-1-[4-{[(2S)-2-フルオロプロピル]オキシ}-2-(トリフルオロメチル)ベンゾイル]-1,2,3,4-テトラヒドロ-5H-1-ベンゾアゼピン-5-イリデン}アセトアミド、
3-[((2Z)-2-{1-[4-(2,2-ジフルオロプロポキシ)-2-(トリフルオロメチル)ベンゾイル]-4,4,7-トリフルオロ-1,2,3,4-テトラヒドロ-5H-1-ベンゾアゼピン-5-イリデン}アセチル)アミノ]プロパンアミド、
(2Z)-2-{4,4-ジフルオロ-1-[4-プロポキシ-2-(トリフルオロメチル)ベンゾイル]-1,2,3,4-テトラヒドロ-5H-1-ベンゾアゼピン-5-イリデン}-N-[(2R)-2,3-ジヒドロキシプロピル]アセトアミド、若しくは、
(2Z)-2-{4,4-ジフルオロ-1-[4-プロポキシ-2-(トリフルオロメチル)ベンゾイル]-1,2,3,4-テトラヒドロ-5H-1-ベンゾアゼピン-5-イリデン}-N-[(2S)-2,3-ジヒドロキシプロピル]アセトアミド、
又はその製薬学的に許容される塩である、請求項１記載の製造法。
The 4,4-difluoro-1,2,3,4-tetrahydro-5H-1-benzazepine derivative represented by the formula (I) according to claim 1 or a pharmaceutically acceptable salt thereof is:
(2Z) -N- (2-Amino-2-oxoethyl) -2- {4,4,7-trifluoro-1- [4-{[(2R) -2-fluoropropyl] oxy} -2- ( Trifluoromethyl) benzoyl] -1,2,3,4-tetrahydro-5H-1-benzazepine-5-ylidene} acetamide,
(2Z) -N- (2-hydroxyethyl) -2- {4,4,7-trifluoro-1- [4-{[(2S) -2-fluoropropyl] oxy} -2- (trifluoromethyl ) Benzoyl] -1,2,3,4-tetrahydro-5H-1-benzazepine-5-ylidene} acetamide,
(2Z) -N- (2-hydroxyethyl) -2- {4,4,7-trifluoro-1- [4-{[(2R) -2-fluoropropyl] oxy} -2- (trifluoromethyl ) Benzoyl] -1,2,3,4-tetrahydro-5H-1-benzazepine-5-ylidene} acetamide,
(2Z) -2- {4,4-Difluoro-1- [4-{[(2R) -2-fluoropropyl] oxy} -2- (trifluoromethyl) benzoyl] -1,2,3,4- Tetrahydro-5H-1-benzazepine-5-ylidene} -N-[(2S) -2,3-dihydroxypropyl] acetamide,
3-[((2Z) -2- {4,4,7-trifluoro-1- [4-{[(2R) -2-fluoropropyl] oxy} -2- (trifluoromethyl) benzoyl] -1 , 2,3,4-tetrahydro-5H-1-benzazepine-5-ylidene} acetyl) amino] propanamide,
(2Z) -N-[(2R) -2,3-Dihydroxypropyl] -2- {4,4,7-trifluoro-1- [4-{[(2R) -2-fluoropropyl] oxy}- 2- (trifluoromethyl) benzoyl] -1,2,3,4-tetrahydro-5H-1-benzazepine-5-ylidene} acetamide,
(2Z) -N- (2-amino-2-oxoethyl) -2- {4,4,7-trifluoro-1- [4-{[(2S) -2-fluoropropyl] oxy} -2- ( Trifluoromethyl) benzoyl] -1,2,3,4-tetrahydro-5H-1-benzazepine-5-ylidene} acetamide,
(2Z) -2- {1- [4- (2,2-difluoropropoxy) -2- (trifluoromethyl) benzoyl] -4,4-difluoro-1,2,3,4-tetrahydro-5H-1 -Benzazepine-5-ylidene} -N- (2-hydroxyethyl) acetamide,
(2Z) -2- {4,4-Difluoro-1- [4-{[(2S) -2-fluoropropyl] oxy} -2- (trifluoromethyl) benzoyl] -1,2,3,4- Tetrahydro-5H-1-benzazepine-5-ylidene} -N- (2-hydroxyethyl) acetamide,
(2Z) -2- {4,4-Difluoro-1- [4-{[(2R) -2-fluoropropyl] oxy} -2- (trifluoromethyl) benzoyl] -1,2,3,4- Tetrahydro-5H-1-benzazepine-5-ylidene} -N- (2-hydroxyethyl) acetamide,
(2Z) -2- {1- [4- (2,2-difluoropropoxy) -2- (trifluoromethyl) benzoyl] -4,4,7-trifluoro-1,2,3,4-tetrahydro- 5H-1-Benzazepine-5-ylidene} -N- (2-hydroxyethyl) acetamide,
(2Z) -N-[(2R) -2,3-dihydroxypropyl] -2- {4,4,7-trifluoro-1- [4-propoxy-2- (trifluoromethyl) benzoyl] -1, 2,3,4-tetrahydro-5H-1-benzazepine-5-ylidene} acetamide,
(2Z) -2- {4,4-Difluoro-1- [4-{[(2S) -2-fluoropropyl] oxy} -2- (trifluoromethyl) benzoyl] -1,2,3,4- Tetrahydro-5H-1-benzazepine-5-ylidene} -N-[(2S) -2,3-dihydroxypropyl] acetamide,
(2Z) -2- {4,4-Difluoro-1- [4-{[(2R) -2-fluoropropyl] oxy} -2- (trifluoromethyl) benzoyl] -1,2,3,4- Tetrahydro-5H-1-benzazepine-5-ylidene} -N-[(2R) -2,3-dihydroxypropyl] acetamide,
3-[((2Z) -2- {4,4,7-trifluoro-1- [4-{[(2S) -2-fluoropropyl] oxy} -2- (trifluoromethyl) benzoyl] -1 , 2,3,4-tetrahydro-5H-1-benzazepine-5-ylidene} acetyl) amino] propanamide,
(2Z) -N-[(2R) -2,3-Dihydroxypropyl] -2- {4,4,7-trifluoro-1- [4-{[(2S) -2-fluoropropyl] oxy}- 2- (trifluoromethyl) benzoyl] -1,2,3,4-tetrahydro-5H-1-benzazepine-5-ylidene} acetamide,
3-[((2Z) -2- {1- [4- (2,2-difluoropropoxy) -2- (trifluoromethyl) benzoyl] -4,4,7-trifluoro-1,2,3, 4-tetrahydro-5H-1-benzazepine-5-ylidene} acetyl) amino] propanamide,
(2Z) -2- {4,4-Difluoro-1- [4-propoxy-2- (trifluoromethyl) benzoyl] -1,2,3,4-tetrahydro-5H-1-benzazepine-5-ylidene } -N-[(2R) -2,3-dihydroxypropyl] acetamide, or
(2Z) -2- {4,4-Difluoro-1- [4-propoxy-2- (trifluoromethyl) benzoyl] -1,2,3,4-tetrahydro-5H-1-benzazepine-5-ylidene } -N-[(2S) -2,3-dihydroxypropyl] acetamide,
Or the manufacturing method of Claim 1 which is its pharmaceutically acceptable salt.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2005309218A JP4765546B2 (en) | 2004-10-27 | 2005-10-25 | Method for producing benzazepine derivative or salt thereof |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2004311914 | 2004-10-27 | ||
| JP2004311914 | 2004-10-27 | ||
| JP2005309218A JP4765546B2 (en) | 2004-10-27 | 2005-10-25 | Method for producing benzazepine derivative or salt thereof |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2006151957A JP2006151957A (en) | 2006-06-15 |
| JP2006151957A5 true JP2006151957A5 (en) | 2009-08-13 |
| JP4765546B2 JP4765546B2 (en) | 2011-09-07 |
Family
ID=36630670
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2005309218A Expired - Fee Related JP4765546B2 (en) | 2004-10-27 | 2005-10-25 | Method for producing benzazepine derivative or salt thereof |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JP4765546B2 (en) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RS56804B1 (en) | 2012-06-11 | 2018-04-30 | Tacurion | Method for producing 4,4,7-trifluoro-1,2,3,4-tetrahydro-5h-1-benzazepine compound and intermediate for synthesis thereof |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH04334403A (en) * | 1991-05-10 | 1992-11-20 | Toto Ltd | Cast molding die for washing basin or the like |
| PL182011B1 (en) * | 1993-08-26 | 2001-10-31 | Yamanouchi Pharma Co Ltd | Benzazepine derivative, pharmaceutic composition and intermediate compounds |
| JP3215910B2 (en) * | 1994-06-15 | 2001-10-09 | 大塚製薬株式会社 | Benzoheterocyclic derivatives |
| JP3599403B2 (en) * | 1995-02-24 | 2004-12-08 | 山之内製薬株式会社 | A new method for producing benzazepine derivatives |
-
2005
- 2005-10-25 JP JP2005309218A patent/JP4765546B2/en not_active Expired - Fee Related
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