JP2006125981A - Analyzer - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To enhance analyzing precision by properly suppressing the evaporation of a sample without increasing the load of a user and an examinee and requiring the complicated control of the analyzer. <P>SOLUTION: In the analyzer 1 for analyzing a specific component in the sample on the basis of a change caused in a reaction phase at the time of reaction of the sample with a reagent, a humidification means 5 for increasing the humidity around the reaction phase is provided. The humidification means 5 is constituted so as to keeping the humidity around the reaction phase to a definite value or above (e.g., a relative humidity of 30% or above). <P>COPYRIGHT: (C)2006,JPO&NCIPI

Description

  The present invention relates to an apparatus for analyzing a specific component in a sample based on a change that occurs in a reaction phase when the sample is reacted with a reagent.

  As a sample analysis method, a method of photometrically measuring the degree of color development of a reagent when the sample is reacted with the reagent is often used. The reaction between the sample and the reagent in this method can be broadly classified into a case where the reaction is performed in a liquid phase using a reaction vessel or the like and a case where a reaction is performed on a solid support using a dry analysis tool. The latter method is widely used because it requires a small amount of sample and can analyze the sample easily and with relatively high accuracy. In this method, an analysis tool provided with one or more reagent pads in which a reagent is supported on a porous layer such as a filter paper is used as an analysis tool. When such an analysis tool is used, the sample is usually analyzed by spotting the sample on the reagent pad and measuring the degree of coloration of the reagent pad in the analyzer. Some analysis tools are configured to measure the degree of coloration of the reaction zone after spotting a sample and a reagent on the reaction zone including the porous layer.

  When analyzing a sample by the above-described method, the sample evaporates while the sample and the reagent are reacted. In particular, when the reaction temperature needs to be set higher than room temperature, the amount of evaporation of the sample increases. Therefore, the detected component is reduced by the amount of the sample evaporated within the intended reaction time, and the measured value is lowered. In particular, when a sample is analyzed using an analytical tool, the amount of sample required is small, so that the sample evaporation results in the measurement result compared to the case where the sample and reagent are reacted in the liquid phase. The impact is great. In order to solve such a problem, it is conceivable to use a sample whose amount is increased by the evaporation amount. However, if the amount of sample required for measurement increases, for example, when using whole blood as a sample, the burden of blood collection on the subject increases.

  In addition, the amount of sample evaporation varies depending on the internal environment of the apparatus. In this case, it appears as an error between measurements (between analysis tools), and when using an analysis tool having multiple reagent pads (reaction zones) Since the amount of evaporation differs for each reagent pad (reaction zone), an error occurs between the reagent pads (reaction zones). In order to solve such problems, the cooling fan incorporated in the apparatus is controlled to control the air blowing state in the apparatus, and the evaporation amount of the sample is made uniform for each measurement or for each reagent pad (reaction zone). It is also possible. However, since various parts are incorporated in the device, it is difficult to control the air flow to such an extent that the evaporation amount of the sample can be made uniform, and the sample can be evaporated while maintaining the function as a cooling fan. It is difficult to control the blowing state to such an extent that the amount can be made uniform.

  Therefore, conventionally, when using an analysis tool, a method of suppressing evaporation of the sample from the reagent pad (reaction zone) or making the evaporation amount from the reagent pad (reaction zone) constant for each measurement has been adopted. .

  As a method of suppressing the evaporation of the sample from the reagent pad (reaction zone), for example, there is a method of reacting the sample and the reagent using the reagent pad (reaction zone) as a closed system (see, for example, Patent Documents 1 and 2). In the method described in Patent Document 1, a reagent and a sample are spotted on the reaction zone, and then the reaction zone is covered with a cap. In this method, the cap is configured to be disposable or reusable. For this reason, when the cap is made disposable, the manufacturing cost or measurement cost of the analysis tool increases, and the running cost increases. On the other hand, when the cap is repeatedly used, contamination may occur and there is a problem in terms of hygiene. On the other hand, the method described in Patent Document 2 is provided with a lid that covers the upper opening of the incubation chamber to suppress evaporation of the sample from the reagent pad in the incubation chamber. In this method, since it is necessary to attach and detach the lid, the measurement operation becomes complicated and the burden on the user increases.

JP-A-6-174728 JP-A-8-334507

  An object of the present invention is to appropriately suppress sample evaporation and improve analysis accuracy without increasing the burden on the user and the subject and without requiring complicated control in the apparatus.

  The present invention is an apparatus for analyzing a specific component in a sample based on a change that occurs in a reaction phase when the sample is reacted with a reagent, and includes a humidity controller for adjusting the humidity around the reaction phase. There is provided an analyzer characterized by the above.

  The humidity controller is provided with humidifying means for increasing the humidity around the reaction phase, for example. The humidity controller can be configured to include a dehumidifying means in addition to the humidifying means.

  The humidity controller is configured, for example, so that the humidity around the reaction phase can be maintained above a certain value. More specifically, the humidity controller further includes control means for adjusting the degree of humidification around the reaction phase by, for example, humidification means.

  The control means is configured to control the humidification means so that the relative humidity becomes 30% or more, for example, and the relative humidity around the reaction phase is a specific relative humidity selected in advance from a range of 60 to 90%. It is preferable that the humidifying means is controlled so as to be. This is because when the relative humidity around the reaction phase is less than 60%, particularly when the relative humidity is less than 30%, the evaporation of the sample in the reaction phase cannot be sufficiently suppressed. Setting the relative humidity around the reaction phase to be larger than 90% is because the running cost of the humidifying means becomes higher than necessary.

  The humidifying means is configured to include, for example, a part of the humidifying means that is open to the outside, a liquid holding tank that holds the liquid, and a heater that heats the liquid held in the liquid holding tank. . In this case, the control means is configured to adjust the degree of humidification around the reaction system, for example, by controlling the heater.

  The analyzer of the present invention analyzes a sample using an analysis tool including one or more reagent parts including a reagent for reacting with a sample (for example, a color former that develops color when reacted with the specific component). Configured as follows.

  The analyzer of the present invention has, for example, a detection means for detecting a change occurring in the reaction phase and a holding portion for holding an analysis tool, and a position where the change in the reaction phase can be detected by the detection means. And a movable tray for moving the analysis tool. The humidity controller is disposed, for example, below the movable tray and is configured to include a humidified gas generating unit for generating humidified gas. The movable tray has, for example, one or more through holes for allowing the gas generated in the humidified gas generation unit to actively exist around one or more reagent parts of the analysis tool held in the holding part. Composed.

  The analyzer 1 shown in FIGS. 1 and 2 is configured to analyze the concentration of a specific component in blood using the test pieces 20 and 21, and includes a housing 3, a test piece mounting table 4, a humidifier. It has a device 5, a pipette device 6, and a photometric device 7.

  The housing 3 defines the external shape of the analyzer 1 and accommodates various elements. The housing 3 has an opening 30, a housing portion 31, and a pair of guide convex portions 32.

  The opening 30 is for allowing a part of the test piece mounting table 4 to protrude outside the housing 3, and is provided on the front surface 33 of the housing 3. The opening 30 is configured to be selected between an open state and a closed state by the front lid 34. In the state where the opening 30 is opened, the inside and outside of the housing 3 communicate with each other, the state in which the test piece mounting table 4 is accommodated in the housing 3, and the majority of the test piece mounting table 4 is the housing. 3 and a state in which the first and the plurality of second slits 41 and 42 are exposed are selectable.

  The accommodating part 31 is for accommodating the bottle 53 of the humidifying device 5 described later, and the upper opening 36 can be closed by the lid 35. That is, at the normal time, the bottle 53 is accommodated in the container 31 and the lid 35 is closed. On the other hand, by opening the lid 35, the bottle 53 can be taken in and out of the container 31. Yes. A joint 36 for inserting a drainage portion 53 </ b> A of the bottle 53 described later is fixed to the bottom surface of the housing portion 31. A tube 56D is connected to the joint 36, and the water held in the bottle 53 can be introduced into the tube 56D.

  The pair of guide convex portions 32 are for engaging with a pair of guide concave portions 43 of the test piece mounting table 4 described later, and for defining a moving path of the test piece mounting table 4. These guide protrusions 32 are provided at intervals in the D1 and D2 directions and extend in the D3 and D4 directions, although they are not clearly shown in the drawing. Each guide convex portion 32 is provided with a plurality of through holes 37 for allowing the movement of the humidified air generated by the humidifier 5.

  The housing 3 is further provided with an operation panel 38 and a display 39. The operation panel 38 is provided with various operation buttons 38A for setting measurement conditions or prescribing the operation of the analyzer 1. The display 39 displays measurement results, operation results of the operation buttons 38A, and the like.

  The test piece mounting table 4 is for mounting the test pieces 20 and 21 and for moving the test pieces 20 and 21 to a target position. The test specimen mounting table 4 can reciprocate in the directions D3 and D4 between the first and second stop positions with respect to the housing 3. The first stop position is a position for placing the test pieces 20 and 21 on the test piece mounting table 4 or removing the test pieces 20 and 21 from the test piece mounting table 4. The second slits 41 and 42 are exposed to the outside of the housing 3. The second stop position is a position for measuring the degree of coloration of the reagent pads 20A and 21A, and is a position where the reagent pads 20A and 21A face a light emitting element 71 of the photometric device 7 described later. In addition to the first and second stop positions, the test piece mounting table 4 places a sample on the third stop position between the first and second stop positions, that is, the reagent pads 20A and 21A of the test pieces 20 and 21. It is possible to stop at the position for wearing.

  Such a test piece mounting table 4 includes a first slit 41, a plurality of (three in this embodiment) second slits 42, a pair of guide recesses 43, a plurality of through holes 44, and a gear portion 45. .

  The first slit 41 is for holding the test piece 20 for multi-component measurement, and extends in the D1 and D2 directions of the housing 3. The test piece 20 for multi-component measurement is provided with a plurality (five in this embodiment) of reagent pads 20A. Each of the reagent pads 20A carries a reagent that reacts with a specific component such as glucose, albumin, calcium, etc., for example. On the other hand, the second slit 42 is for holding the test piece 21 for single component measurement, and extends in the directions D3 and D4 of the housing 3. The test piece 21 for single component measurement is provided with one reagent pad 21A. The reagent pad 21A carries a reagent that reacts with a specific component such as glucose, albumin, calcium, etc., for example.

  The pair of guide concave portions 43 are for engaging with the pair of guide convex portions 32 provided in the housing 3. That is, the test piece mounting table 4 is configured to be moved in the D3 and D4 directions along the pair of guide convex portions 32 by engaging each guide concave portion 43 with the corresponding guide convex portion 32. .

  The plurality of through holes 44 are for making it easy for humidified air from the humidifier 5 described later to gather around the reagent pads 20A and 21A in the test pieces 20 and 21. These through holes 44 are provided around the reagent pads 20A and 21A in a state where the test pieces 20 and 21 are placed in the first and second slits 41 and 42, respectively.

  The gear part 45 is a part for inputting the rotational driving force of the motor 46 to the test piece mounting table 4. The gear portion 45 has a plurality of teeth (not shown) for engaging with a gear 48 fixed to the output shaft 47 of the motor 46. Therefore, the test piece mounting table 4 is moved in the D3 direction or the D4 direction with respect to the housing 3 in accordance with the rotation direction of the output shaft 47 of the motor 46. Thereby, the test piece mounting table 4 can be reciprocated between the first stop position and the second stop position.

  As shown in FIGS. 2 and 3, the humidifying device 5 is for maintaining the humidity around the reagent pads 20A and 21A of the test pieces 20 and 21 at a predetermined value or more, and includes a control unit 50, a hygrometer. 51, a humidified air generating unit 52, a bottle 53, and a valve 54.

  The control unit 50 is for controlling the operation of the humidifier 5. The control unit 50 performs, for example, opening / closing control of the valve 54 and operation control of the heater 58 and the fan 59 of the humidified air generating unit 52 described later.

  The hygrometer 51 is for measuring the humidity around the reagent pads 20A and 21A in the test pieces 20 and 21, and is fixed to a holder 70 of the photometric device 7 described later. The observation result of the hygrometer 51 is monitored by the control unit 50.

  The humidified air generating unit 52 is for generating humidified air, and is disposed below the test piece mounting table 4. The humidified air generating unit 52 includes a case 55, a tank 56, a water level sensor 57, a heater 58 and a fan 59.

  The case 55 is for accommodating various elements, and has a plurality of through holes 55B provided in the upper wall 55A. The plurality of through holes 55 </ b> B are for discharging humidified gas discharged from a tank 56 described later to the outside of the humidified air generating unit 52.

  The tank 56 holds water necessary for humidifying the air, and has a plurality of through holes 56B provided in the upper wall 56A. The plurality of through holes 56 </ b> B are for discharging humidified air generated inside the tank 56 to the outside of the tank 56. A tube 56D is fixed to the side wall 56C of the tank 56, and the inside of the tank 56 communicates with the inside of the tube 56D.

  The water level sensor 57 is for grasping the remaining amount of water held in the tank 56, and is fixed to the upper wall 56 </ b> A of the tank 56. The observation result of the water level sensor 57 is monitored by the control unit 50.

  The heater 58 is for heating and vaporizing water held in the tank 56, and its operation is controlled by the control unit 50. For example, the control unit 50 monitors the observation result of the hygrometer 51, and operates the heater 58 so that the humidity observed in the hygrometer 51 is maintained in a target range (to the extent that the water in the tank 56 is heated). To control. More specifically, the controller 50 increases the amount of heating by the heater 58 to increase the amount of humidified air when the humidity observed by the hygrometer 51 is likely to fall below or below the target value. The heater 58 is controlled so as to increase. In contrast, when the humidity observed by the hygrometer 51 is likely to exceed or exceed the target value, the control unit 50 reduces the amount of heating by the heater 58 to reduce the amount of humidified air generated. Thus, the heater 58 is controlled. The target humidity value in the control unit 50 is selected, for example, from 30% or more, more preferably from 60 to 90% in relative humidity.

  The fan 59 is for moving the humidified air inside the case 55 toward the through hole 55 </ b> B of the case 55, and its operation is controlled by the control unit 50. The control unit 50 controls the operation of the fan 59 (increase / decrease in the rotational speed of the fan 59), for example, according to the monitoring result of the hygrometer 51. More specifically, the control unit 50 increases the number of rotations of the fan 59 to increase the supply amount of humidified air when the humidity observed in the hygrometer 51 is likely to fall below or below the target value. The fan 59 is controlled so that On the other hand, when the humidity observed in the hygrometer 51 is likely to exceed the target value or exceeds the target value, the control unit 50 decreases the rotation speed of the fan 59 to reduce the supply amount of humidified air. Thus, the fan 59 is controlled.

  In the humidified air generation unit 52, when the water in the tank 56 is heated by the heater 58, the water in the tank 56 is positively evaporated. The water vapor (humidified air) generated at this time is discharged to the outside of the tank 56 through the through hole 56 </ b> B of the tank 56. On the other hand, in the humidified air generating unit 52, the fan 59 is driven so as to generate an upward airflow, and the humidified air is supplied to the case 55 (humidified air generating unit via the through hole 55B of the case 55. 52).

  The bottle 53 is for holding water to be supplied to the tank 56, and is held in the housing portion 31 of the housing 3. The bottle 53 has a discharge portion 53A for discharging water contained therein. The discharge portion 53A is inserted into the joint 36 of the housing portion 31, and the inside of the bottle 53 communicates with the tube 56D via the joint 36. The tube 56D communicates with the inside of the tank 56 as described above. Therefore, the water stored in the bottle 53 can be supplied to the tank 56 in a state where the bottle 53 is stored in the storage portion 31.

  The valve 54 is for selecting a state where water is supplied to the tank 56 and a state where water is not supplied to the tank 56, and is normally closed. The valve 54 is controlled to be opened and closed by the control unit 50. More specifically, the control unit 50 monitors the observation result of the water level sensor 57, and when it is determined that the remaining amount of water in the tank 56 is below a certain value based on the monitoring result, the valve 54 is turned on. Open. On the other hand, the control unit 50 causes the valve 54 to be closed when the water level observed by the water level sensor 57 reaches the target water level or when a certain period of time has elapsed since the valve 54 was opened. The valve 54 is controlled.

  The pipette device 6 shown in FIG. 2 is for sucking a sample such as blood and spotting it on the reagent pads 20A and 21A of the test pieces 20 and 21. Although not shown clearly on the drawing, the pipette device 6 is movable in the vertical direction and the horizontal direction.

  The photometric device 7 is for grasping the coloration state of the reagent pads 20A and 21A of the test pieces 20 and 21. The photometric device 7 has a light emitting element 71 and a light receiving element 72 fixed to a holder 70. The light emitting element 71 is for irradiating light to the reagent pads 20A and 21A of the test pieces 20 and 21, and is composed of, for example, an LED lamp. On the other hand, the light receiving element 72 is for receiving the reflected light from the reagent pads 20A and 21A, and is constituted by a photodiode, for example.

  Next, a sample analysis operation using the analyzer 1 will be described.

  When analyzing the sample using the analyzer 1, first, the test pieces 20 and 21 are set on the test piece mounting table 4. The set of the test pieces 20 and 21 moves the test piece mounting table 4 to the front side of the housing 3 to stop the test piece mounting table 4 at the first stop position, and sets the first slit 41 and the second slit 42. Each is performed in an exposed state. This state is automatically achieved, for example, by pressing a predetermined operation button 38A or by opening the front cover 34. When the test pieces 20 and 21 are set on the test piece mounting table 4, the front cover 34 is closed after the test piece mounting table 4 is moved into the housing 3. The movement of the test specimen mounting table 4 to the inside of the housing 3 is automatically achieved, for example, by pressing a predetermined operation button 38A or by closing the front cover 34.

  At this time, in the analyzer 1, the humidity inside the housing 3 is monitored by the control unit 50, and the humidified air generation unit 52 is controlled by the control unit 50 according to the monitoring result. Such control of the humidified air generating unit 52 by the control unit 50 is performed unless the main power supply of the analyzer 1 is turned off or the operation of the humidified air generating unit 52 is not stopped by the user. That is, the operation of the humidified air generating unit 52 is controlled by the control unit 50 regardless of whether the test pieces 20 and 21 are present inside the housing 3.

  Here, the test pieces 20 and 21 to be set on the test piece mounting table 4 are selected according to the type of the specific component to be measured. As described above, when measuring a plurality of specific components, the test piece 20 for multi-component measurement is set in the first slit 41 of the test piece mounting table 4. On the other hand, when the measurement is performed only for a specific component that cannot be handled by the test piece 20 for multi-component measurement, or for one specific component that can be measured by the test piece 20 for multi-component measurement, The component measurement test pieces 21 are individually set in the second slits 42.

  When the setting of the test pieces 20 and 21 is completed as described above, for example, the concentration of the specific component is automatically measured. The measurement in the analyzer 1 is performed by spotting a sample on the reagent pads 20A and 21A and then measuring the coloration state of the reagent pads 20A and 21A by an optical method.

  The spotting of the sample on the reagent pads 20 and 21 is performed using the pipette device 6 after moving the test specimen mounting table 4 from the first stop position to the third stop position. The spotting by the pipette device 6 is performed by, for example, sucking a sample stocked in the housing 3 and then discharging the sample to the reagent pads 20A and 21A to be measured.

  On the other hand, the photometric measurement of the colored state of the reagent pads 20A and 21A is performed after the sample and the reagent of the reagent pads 20A and 21A are reacted for a certain time after the sample is spotted.

  The reaction between the sample and the reagent is performed while maintaining the humidity around the reagent pads 20A and 21A constant in a state where the test piece mounting table 4 is stopped at the third stop position. The humidity around the reagent pads 20A and 21A is maintained by the control unit 50 controlling the operation of the humidified air generating unit 52. That is, the control unit 50 monitors the measurement result of the hygrometer 51 and controls the heating amount of the heater 58 and the rotation speed of the fan 59 in the humidified air generation unit 52 according to the monitoring result.

  In the humidified air generating unit 52, the humidified air is discharged from the through hole 55B of the case 55 as described above. On the other hand, the humidified air generating unit 52 is disposed below the test piece mounting table 4, and the test piece mounting table 4 is provided with a plurality of through holes 44. Therefore, the humidified gas generated in the humidified air generating unit 52 is guided to the upper surface side of the test piece mounting table 4 through each through hole 44. The plurality of through holes 44 are formed around the reagent pads 20A and 21A. Therefore, in the analyzer 1, the surroundings of the reagent pads 20A and 21A can be actively and efficiently humidified.

  Photometry of the reagent pads 20A and 21A is performed using the photometry device 7 after the test piece mounting table 4 is moved from the third stop position to the second stop position. In the photometric device 7, each light emitting element 71 emits light to the corresponding reagent pads 20 </ b> A and 21 </ b> A. On the other hand, each light receiving element 72 of the photometric device 7 receives light reflected by the reagent pads 20A and 21A. Then, the degree of coloration of each reagent pad 20A, 21A and the concentration of a specific component contained in plasma are calculated according to the output from the photometric device 7 corresponding to each reagent pad 20A, 21A.

  Since the analysis apparatus 1 includes the humidifier 5, when measuring using a plurality of test pieces 20, 21 in one measurement, or using a test piece 20 having a plurality of reagent pads 20 </ b> A. In this case, the humidity around each of the reagent pads 20A and 21A can be similarly maintained. Therefore, in the analyzer 1, since the variation in the evaporation amount of the sample for each reagent pad 20A, 21A can be suppressed, the variation in the measurement error for each reagent pad 20A, 21A can be suppressed.

  Similarly, in the analyzer 1, since the humidity in each analysis is the same, the amount of evaporation from the reagent pads 20A and 21A in each measurement can be the same. Thereby, the dispersion | variation for every measurement can be suppressed.

  In the analyzer 1, the effect of suppressing the variation between the reagent pads 20 </ b> A and 21 </ b> A or the effect of suppressing the variation between a plurality of measurements can be achieved by providing the humidifying device 5. Therefore, at the time of measurement, it is not necessary to put a cap on the reagent pads 20A and 21A in order to suppress the evaporation of the sample from the reagent pads 20A and 21A. As a result, it is not necessary for the user to perform the work of putting the cap on the reagent pads 20A and 21A, so that the burden on the user is reduced. In addition, the running cost can be reduced as compared with the case where the cap is used because the cap does not need to be used.

  Furthermore, in the analyzer 1, the humidified air generating unit 52 can be controlled so as to maintain the inside of the housing 3 at high humidity. In that case, the amount of evaporation from the reagent pads 20A and 21A can be reduced. Thereby, the amount of the sample to be spotted on the reagent pads 20A and 21A can be reduced. As a result, when blood is used as a sample, the burden of blood collection on the subject is reduced.

  The present invention is not limited to the configuration adopted in the above-described embodiment. The configuration of the humidified air generating unit is not limited to that described in the present embodiment, and for example, a unit that generates a humidified gas other than humidified air or a unit that humidifies with a liquid other than water may be used. Further, the location of the humidified air generating unit is not necessarily below the test piece mounting table. Furthermore, the present invention is not limited to an analyzer that analyzes a sample using the test piece shown in the present embodiment, but is also applied to an analyzer that analyzes a sample using an analysis tool of another form. Can do.

It is a whole perspective view which shows an example of the analyzer which concerns on this invention. It is sectional drawing which follows the II-II line of FIG. It is sectional drawing for demonstrating the humidification air generation | occurrence | production unit in the analyzer shown in FIG.

Explanation of symbols

1 Analyzer 20, 21 Test piece (analytical tool)
20A, 21A (test piece) reagent pad (dry reagent part)
4 Test specimen mounting table (movable tray)
41 First slit (of the test specimen mounting table) (movable tray holder)
42 Second slit (of the test specimen mounting table) (movable tray holder)
5 Humidifier (humidifying means)
50 Control unit (control means)
52 Humidification air generation unit (humidification gas generation unit)
56 Tank (for humidified air generation unit) (Liquid holding tank)
7 Photometric device (detection means)

Claims (9)

An apparatus for analyzing a specific component in a sample based on a change that occurs in a reaction phase when the sample is reacted with a reagent,
An analyzer comprising a humidity controller for adjusting the humidity around the reaction phase.   The analyzer according to claim 1, wherein the humidity controller includes humidifying means for increasing humidity around the reaction phase.   The analyzer according to claim 2, wherein the humidity controller is configured to maintain a humidity around the reaction phase at a predetermined value or more. The humidity controller further includes control means for adjusting the degree of humidification around the reaction phase by the humidifying means,
The analyzer according to claim 3, wherein the control unit is configured to control the humidifying unit so that a relative humidity becomes 30% or more.   The said control means is comprised so that the said humidification means may be controlled so that the relative humidity around the said reaction phase may become the specific relative humidity previously selected from the range of 60 to 90%. The analyzer described. The humidifying means is partially open to the outside, and includes a liquid holding tank that holds the liquid, and a heater for heating the liquid held in the liquid holding tank,
The analyzer according to claim 4 or 5, wherein the control means is configured to adjust the degree of humidification around the reaction system by controlling the heater.   The analyzer according to any one of claims 1 to 6, wherein the analyzer is configured to analyze the sample using an analysis tool including one or more reagent parts including a reagent for reacting with the sample.   The analysis tool is configured to analyze a sample using a tool in which a plurality of dry reagent parts containing a color former that develops a color when reacted with the specific component is fixed on a substrate. 8. The analyzer according to 7. Detection means for detecting changes occurring in the reaction phase;
A movable tray for moving the analysis tool to a position having a holding part for holding the analysis tool and capable of detecting a change in the reaction phase by the detection means;
And further comprising
The humidity controller is disposed below the movable tray and includes a humidified gas generation unit for generating a humidified gas.
The movable tray has one or more through holes for allowing the gas generated in the humidified gas generation unit to actively exist around one or more reagent parts of the analysis tool held by the holding part. The analyzer according to claim 7 or 8.

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