JP2006069966A - Composition for oral cavity - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To provide a composition for oral cavity having improved antibacterial effect against bacteria forming a biofilm and exhibiting excellent antibacterial activity against bacteria and plaque having the form of biofilm by using a pectinase known as a kind of carbohydrase in combination with one or more antibacterial agents selected from scarcely water-soluble metal salt compound of an antibacterial metal and zeolite supporting an antibacterial metal ion. <P>SOLUTION: The composition for oral cavity is produced by compounding a pectinase with one or more antibacterial agents selected from scarcely water-soluble metal salt compound of an antibacterial metal and zeolite supporting an antibacterial metal ion. <P>COPYRIGHT: (C)2006,JPO&NCIPI

Description

  The present invention relates to an oral composition that exhibits excellent antibacterial activity against oral bacteria and plaques in the form of a biofilm in which an antibacterial agent alone is unlikely to act.

  It is a well-known reason that plaque formed by bacteria in the oral cavity is a pathogenic factor for oral diseases such as caries, periodontal disease and bad breath, and that plaque removal is important in oral hygiene. Plaque is in the form of a biofilm, and it is difficult for drugs such as bactericides to be effective than existing in a floating state. Conventionally, bactericides such as chlorhexidine and triclosan have been used for the purpose of removing oral bacteria. The effect on bacteria present as a film was not satisfactory.

  Therefore, the penetrability of the bactericide is improved (Patent Document 1; see JP-A-11-255629), the retention is improved (Patent Document 2; see JP-A-04-139119), and the sensitivity is improved (Patent Document 3; 2002-370953), enzyme development (Patent Document 4; Patent 2898079, Patent Document 5; Special Table 2002-526069) and the like have been proposed. Instead, it is desired to develop an oral composition having an antibacterial effect on biofilm-forming bacteria with higher effectiveness.

JP-A-11-255629 JP 04-139119 A JP 2002-370953 A Japanese Patent No. 2898079 Japanese translation of PCT publication No. 2002-526069 Japanese Patent Laid-Open No. 8-26955

  This invention is made | formed in view of the said situation, and it aims at providing the composition for oral cavity which has the outstanding antimicrobial effect with respect to plaque, especially biofilm formation intraoral bacteria.

  As a result of intensive research to achieve the above object, the present inventor has found that pectinase, which is one kind of carbohydrolase, and one or more kinds selected from a poorly water-soluble metal salt compound of an antibacterial metal and an antibacterial metal ion-carrying zeolite. By using two or more antibacterial agents in combination, the antibacterial effect of the antibacterial agent on the biofilm-forming oral bacteria is synergistically improved by pectinase, and the antibacterial effect on the oral bacteria that have formed the biofilm is remarkable. As a result, it was found that an oral composition excellent in antibacterial effect was obtained, and the present invention was completed.

  Patent Document 4 discloses an antibacterial composition containing a specific enzyme and an antibacterial agent, and Patent Document 5 discloses a method for destroying a microbial biofilm using a polypeptide having a specific hydrase activity. A combination formulation of an enzyme such as carbohydrase and an antibacterial agent is disclosed. However, from these patent documents, pectinase, which is a kind of carbohydrolase, has an action to improve the antibacterial effect of the antibacterial metal poorly water-soluble metal salt compound and the antibacterial metal ion-supported zeolite against biofilm-forming oral bacteria. Having it is not by analogy.

  Therefore, the present invention is an oral cavity characterized by comprising pectinase and one or more antibacterial agents selected from a poorly water-soluble metal salt compound of an antibacterial metal and an antibacterial metal ion-carrying zeolite. A composition is provided.

  The oral composition of the present invention uses pectinase, which is one type of carbohydrase, and one or more antibacterial agents selected from a poorly water-soluble metal salt compound of an antibacterial metal and an antibacterial metal ion-carrying zeolite. As a result, the antibacterial effect on the oral bacteria that formed the biofilm is improved, and the antibacterial activity is excellent against the oral bacteria and plaque taking the form of a biofilm.

  Hereinafter, the present invention will be described in more detail. The composition for oral cavity of the present invention comprises pectinase and an antibacterial agent selected from an antibacterial metal poorly water-soluble metal salt compound and an antibacterial metal ion-carrying zeolite. Is.

  The pectinase used in the present invention is an enzyme that cleaves glycosidic bonds of pectin substances, mainly poly 1,4-alpha-d-galacturonide and its derivatives, and includes pectate lyase (EC 4.2.2.2), pectin lyase ( EC 4.2.2.10), polygalacturonase (EC 3.2.1.15), exo-polygalacturonase (EC 3.2.1.67), exo-polygalacturonic acid lyase (EC 4.2.2.9) and exo-poly-α-galacturonosidase (EC 3.2.1.82) (in parentheses are classification numbers according to the International Biochemical Union). Among them, polygalacturonase (EC 3.2.1.15), pectate lyase (EC 4.2.2.2), pectin lyase (EC 4.2.2.10) that degrade glycosidic bonds at random. Can be preferably used. These enzymes do not need to be purified, and may have pectin degradation activity as a whole even if they contain a mixture of the above enzymes, a mixture with other enzymes, and other impurities.

  Pectinase used in the present invention include Aspergillus species (Aspergillus niger (Aspergillus niger), Aspergillus Puruberurentsusu (Aspergillus pulverulentus), Aspergillus japonicus (Aspergillus japonicus)), Rhizopus species (Rhizopus oryzae (Rizopus oryzae.), Rhizopus nigricans (Rizopus nigricans) ), Bacillus species (Bacillus subtilis), etc., and are obtained from Amano Enzyme Co., Ltd., Nagase ChemteX Co., Ltd., Novozymes Japan Co., Ltd., Yakult Pharmaceutical Co., Ltd., etc. What can be used can be used.

  The blending amount of pectinase is not particularly limited, but is preferably 0.01 to 10% (mass percentage, hereinafter the same) of the whole composition, and particularly preferably 0.1 to 5%. If the blending amount is less than 0.01%, the effect of the present invention may not be sufficiently obtained, and if it exceeds 10%, it may be disadvantageous in terms of formulation stability and cost.

Next, the composition for oral cavity of the present invention is selected from an antibacterial metal poorly water-soluble metal salt compound as an antibacterial agent, and an antibacterial metal ion-carrying zeolite in which ion-exchangeable ions in the zeolite are substituted with antibacterial metal ions. 1 type or 2 types or more are blended.
Here, examples of the antibacterial metal used in the present invention include silver, copper, zinc, lead, tin, bismuth, cadmium, chromium, nickel, and cobalt. In particular, one or more antibacterial metals selected from silver, zinc, and copper are more preferably used from the viewpoints of antibacterial action, discoloration, and safety to the human body.

  As the poorly water-soluble metal salt compound of the antibacterial metal, the above-mentioned poorly water-soluble salt of the antibacterial metal can be used, for example, zinc oxide, zinc citrate, zinc stearate, zinc undecylenate, zinc hydroxide, zinc oxalate, Zinc phosphate, silver oxide, silver chloride, copper hydroxide, silver carbonate, silver phosphate, lead carbonate, tin hydroxide, bismuth hydroxide, cadmium carbonate, chromium fluoride, chromium phosphate, nickel carbonate, cobalt hydrogen phosphate Among them, zinc oxide and silver oxide are preferable. In the present invention, “poorly water-soluble” is defined as the property of a solute in which the amount of a solute dissolved in 100 mL of water as a solute is 20 ° C. or less and 0.5 g or less.

  Further, the antibacterial metal ion-carrying zeolite is obtained by substituting ions capable of exchanging ions in the zeolite with ions of the antibacterial metal.

Zeolite is generally an aluminosilicate having a three-dimensional framework structure and is represented by the following general formula (1).
_{XM 2 / n O · Al 2} O 3 · YSiO 2 · ZH 2 O (1)
In the above formula (1), M represents an ion-exchangeable ion, and is usually a monovalent or divalent metal ion, such as sodium ion, calcium ion, potassium ion, magnesium ion, or iron ion. n is the valence of the metal ion. X is a coefficient of metal oxide, Y is a coefficient of silica, and Z represents the number of crystal water.

  Here, there are both natural and synthetic zeolites. About 40 kinds of natural ones and about 200 or more synthetic ones are already known. In the present invention, natural zeolite and synthetic ones are known. Any of zeolite may be sufficient. Specific examples of the zeolite are not particularly limited. For example, A-type zeolite, X-type zeolite, Y-type zeolite, T-type zeolite, high silica zeolite, sodalite, mordenite, analcite, clinopti Lolite, chabasite, erionite, etc. can be mentioned. Among these, natural zeolite contains impurities and lacks homogeneity, so synthetic zeolite is preferable, and A-type zeolite, X-type zeolite, Y-type zeolite, and mordenite are particularly preferable.

  Further, as the antibacterial metal ion supported on the zeolite, the metal ion of the antibacterial metal similar to the above-mentioned poorly water-soluble metal salt compound of the antibacterial metal can be used, and among them, one kind selected from silver, zinc and copper or Two or more metal ions are preferred.

  The antibacterial metal ion-carrying zeolite according to the present invention is obtained by replacing the ion-exchangeable ion (M) in the zeolite represented by the above formula (1) with the metal ion of the antibacterial metal. The content of the antibacterial metal ion is preferably 0.1 to 25% in the zeolite in terms of the antibacterial effect.

As such an antibacterial metal ion-carrying zeolite, a commercially available product can be used, and the production method is not particularly defined. However, as a method for producing the antibacterial zeolite, for example, it is described in Patent Document 6 (JP-A-8-26955). Those prepared by adopting the following method can be preferably used.
That is, the zeolite is brought into contact with a mixed aqueous solution containing antibacterial metal ions such as silver ions, copper ions, and zinc ions prepared in advance to replace the ion-exchangeable ions in the zeolite with the antibacterial metal ions. The contact is suitably performed at 10 to 70 ° C., preferably 40 to 60 ° C. for 3 to 24 hours, preferably 10 to 24 hours. In addition, it is appropriate to adjust the pH of the mixed aqueous solution to 3 to 10, preferably 5 to 7. Such adjustment is preferable because precipitation of silver oxide or the like on the zeolite surface or in the pores can be prevented. In addition, each antibacterial metal ion in the mixed aqueous solution is usually supplied as a salt. For example, nitrate, sulfate, perchlorate, acetate, etc. can be used.

  The content of antibacterial metal ions in the zeolite can be appropriately controlled by adjusting the concentration of each antibacterial metal ion in the mixed aqueous solution. For example, when the antibacterial metal ion-carrying zeolite contains silver ions, the silver ion content is suitably 0.1 to 5% by adjusting the silver ion concentration in the mixed aqueous solution to 0.002 to 0.15 mol / l. The antibacterial zeolite can be obtained. When the antibacterial metal ion-carrying zeolite further contains copper ions and zinc ions, the copper ion concentration in the mixed aqueous solution is 0.1 to 0.85 mol / l, and the zinc ion concentration is 0.15 to 1.2 mol. By setting / l, an antibacterial metal ion-supported zeolite having a copper ion content of 0.1 to 8% and a zinc ion content of 0.1 to 8% can be obtained as appropriate. In addition to the above mixed aqueous solution, the antibacterial metal ion-carrying zeolite can be ion-exchanged by using an aqueous solution containing each antibacterial metal ion alone and sequentially contacting each aqueous solution with the zeolite. The concentration of each antibacterial metal ion in each aqueous solution can be determined according to the concentration of each antibacterial metal ion in the mixed aqueous solution.

  The zeolite after the ion exchange is sufficiently washed and then dried. Drying is preferably performed at 105 to 115 ° C. or 70 to 90 ° C. under reduced pressure (0.1 to 4 kPa). It should be noted that ion exchange of ions and organic ions without suitable water-soluble salts such as tin and bismuth can be carried out using an organic solvent solution such as alcohol or acetone so that hardly soluble basic salts do not precipitate.

  The antibacterial metal poorly water-soluble metal salt compound and the antibacterial metal ion-carrying zeolite used in the present invention may be used alone or in combination, and the antibacterial metal poorly water-soluble metal salt compound or antibacterial metal ion Two or more of any one of the supported zeolites may be used in combination of one or more of the water-insoluble metal salt compound of the antibacterial metal and one or more of the antibacterial metal ion-supported zeolite.

  The total amount of the antibacterial metal poorly water-soluble metal salt compound and the antibacterial metal ion-carrying zeolite is preferably 0.001 to 10%, more preferably 0.01 to 5% in the composition. If the blending amount is less than 0.001%, the effects of the present invention may not be sufficiently obtained, and if it exceeds 10%, it may be disadvantageous in terms of formulation stability and cost.

  The oral composition of the present invention can be in the form of toothpaste, toothpaste, toothpaste such as liquid toothpaste, mouthwash, mouth freshener, gargle tablet, denture cleaner, chewing gum, etc. Depending on the characteristics of the dosage form, other components can be blended as optional components within a range not impairing the effects of the present invention, and can be prepared by ordinary methods. For example, for dentifrices, abrasives, thickeners (humectants), binders, surfactants, sweeteners, fragrances, other preservatives, colorants, pH adjusters, excipients, various medicinal effects Components and the like can be blended.

As abrasives, dicalcium phosphate (dihydrate or anhydride), primary calcium phosphate, tertiary calcium phosphate, calcium pyrophosphate, calcium carbonate, aluminum hydroxide, alumina, magnesium carbonate, tertiary magnesium phosphate, insoluble metaphosphoric acid Examples include sodium, insoluble potassium metaphosphate, titanium oxide, anhydrous silicic acid, hydrous silicic acid, titanium silicate, zirconium silicate, and synthetic resin-based abrasives. 5 to 80% is good, preferably 10 to 50%.
As a binder, carrageenan, sodium carboxymethylcellulose, methylcellulose, ethylcellulose, cellulose acetate, sodium hydroxyethylcellulose, sodium alginate, xanthan gum, tragacanth gum, karaya gum, arabiya gum, locust bean gum, polyvinyl alcohol, sodium polyacrylate, carboxyvinyl polymer, Examples include polyvinylpyrrolidone, carbopol, silica gel, aluminum silica gel, thickening silica, bee gum, and laponite (the amount is usually 0.1 to 5.0%).

  Examples of the thickener include glycerin, sorbitol, ethylene glycol, propylene glycol, polyethylene glycol, polypropylene glycol, xylitol, maltitol, and lactol (the amount is usually 1 to 80%).

  As the surfactant, an anionic surfactant, a cationic surfactant, a nonionic surfactant, and an amphoteric surfactant can be blended. As the anionic surfactant, sodium lauryl sulfate, sodium myristyl sulfate, N -Sodium lauroyl sarcosinate, sodium N-myristoyl sarcosinate, sodium dodecylbenzene sulfonate, hydrogenated coconut fatty acid monoglyceride sodium monosulfate, sodium lauryl sulfoacetate, sodium α-olefin sulfonate, sodium N-palmitoyl glutamate, etc. N-acyl glutamate, N-acyl taurate such as N-methyl-N-acyl taurine sodium, and the like. Nonionic surfactants include sucrose fatty acid esters, sucrose fatty acid esters such as maltose fatty acid ester, sugar alcohol fatty acid esters such as maltitol fatty acid ester, lactol fatty acid ester, alkylol amide, polyoxyethylene sorbitan monostearate, etc. Polyoxyethylene sorbitan fatty acid ester, polyoxyethylene fatty acid ester such as polyoxyethylene hydrogenated castor oil, fatty acid diethanolamide such as lauric acid mono- or diethanolamide, sorbitan fatty acid ester, polyoxyethylene higher alcohol ether, polyoxyethylene polyoxypropylene Examples include copolymers, polyoxyethylene polyoxypropylene fatty acid esters, polyglycerin fatty acid esters, and pluronics. In addition, as the zwitterionic surfactant, N-alkyldiaminoethylglycine such as 2-alkyl-N-carboxymethyl-N-hydroxyethylimidazolium betaine, N-lauryldiaminoethylglycine, N-myristyldiaminoethylglycine, or N -Alkyl-1-hydroxyethyl imidazoline betaine sodium etc. are mentioned. These surfactants may be used alone or in combination of two or more.

  The blending amount of the surfactant is 0.001 to 10% of the entire composition, preferably 0.01 to 5%, and particularly preferably 0.1 to 2%.

  Examples of the sweetener include saccharin sodium, stevioside, stevia extract, paramethoxycinnamic aldehyde, neohesperidyl hydrochalcone, perlartin, glycyrrhizin, thaumatin, asparatylphenylalanine methyl ester, and the like, which can be blended in an effective amount.

  As fragrances, menthol, anethole, carvone, eugenol, limonene, n-decyl alcohol, citronellol, α-terpineol, citronellyl acetate, cineol, linalool, ethyl linalool, crocodile, thymol, spearmint oil, peppermint oil, lemon oil, orange Oil, sage oil, rosemary oil, cinnamon oil, pimento oil, cinnamon oil, perilla oil, winter green oil, clove oil, eucalyptus oil and the like can be mentioned, and they can be blended in an effective amount.

  As preservatives other than those mentioned above, various parabens, nonionic antibacterial agents such as sodium benzoate and triclosan, cationic antibacterial agents such as benzethonium chloride and cetylpyridinium chloride, and essential oil components are included in effective amounts. Is possible.

  Active ingredients include enzymes other than pectinase such as dextranase, amylase, proteinase and mutanase, alkali metal monofluorophosphates such as sodium monofluorophosphate, fluorides such as sodium fluoride and stannous fluoride, tranexam Acid, epsilon aminocaproic acid, aluminum chlorohydroxy allantoin, azulene, glycyrrhizinate, glycyrrhetinic acid, sodium chloride, vitamin C, anti-inflammatory agents such as vitamin C, E, copper chlorophyll, copper gluconate, cetyl pyridinium chloride, benzalkonium chloride, Bactericides such as triclosan, hinokitiol, lysozyme chloride, tartar preventives such as polyphosphates, tobacco crab removers such as polyethylene glycol and polyvinylpyrrolidone, perception of aluminum lactate, potassium nitrate, etc. Satoshi prophylactic agents may incorporated. In addition, the compounding quantity of an active ingredient can be made into an effective amount.

  EXAMPLES Hereinafter, although an experimental example, an Example, and a comparative example are shown and this invention is demonstrated concretely, this invention is not restrict | limited to the following Example. In the following examples, the blending amount is mass%.

[Experimental example]
The following 5 strains were cultured under anaerobic conditions at 37 ° C. in THB medium (Todd Hewitt broth medium, Nippon Becton Dickinson Co., Ltd.).
Species used:
(1) Streptococcus sanguinis (Streptococcus sanguinis ATCC 10556)
(2) Actinomyces naeslundy (Actinomyces naeslundii ATCC 51655)
(3) Bayonella parvula (Veillonella parvula ATCC17745)
(4) Fusobacterium nucleatum (CCC10953)
(5) Streptococcus mutans ATCC25175

The culture solution was inoculated into 1000 mL of BMM medium having the following composition so that the cell concentration was 10 ⁶ cells / mL, and continuous culture was started (anaerobic, 37 ° C., stirred at 100 rpm, 100 mL of fresh BMM medium for 1 hour) With continuous replacement). 200 mL of the above continuous culture solution was transferred to another container, and a rotor fixed with hydroxyapatite (HA) was rotated at 37 ° C. for 2 days at about 100 rpm to form a biofilm on the HA. The bacterial solution was continuously replaced by 20 mL per hour, and replaced with THB medium containing 1% sucrose three times a day, and culture was performed for 30 minutes to promote biofilm formation.

BMM (Basal Medium Mucin) medium composition:
Proteose peptone ^{* 1} 0.2%
East Extract ^{* 1} 0.1
Tripty case peptone ^{* 1} 0.1
Porcine stomach mucin ^{* 2} 0.25
KCl ^{* 3} 0.05
L-cysteine hydrochloride ^{* 3} 0.01
Water remaining
Total 100%
* 1: Nippon Becton Dickinson Co., Ltd. * 2: Sigma-Aldrich Japan Co., Ltd. * 3: Wako Pure Chemical Industries, Ltd.

  The formed biofilm was subjected to drug treatment (37 ° C., 3 minutes) using the samples shown in Table 1 below, and cultured for 18 hours in HI medium (Heart infusion (Heart Infusion) medium, Nippon Becton Dickinson Co., Ltd.). (37 ° C., anaerobic) and ultrasonically dispersed in physiological saline. The dispersion was serially diluted and then smeared on a plate medium to determine the number of viable bacteria. As a flat plate medium, the THB medium is used for the measurement of the total number of the five bacterial species of (1) to (5) above, and the mutans bacteria (Streptococcus mutans ATCC25175 of (5) above) is used as a caries-causing bacterium. )) Was measured using MSB medium (Mitiss Salivarius medium (Nippon Becton Dickinson Co., Ltd.) with bacitracin (Sigma Aldrich Japan Co., Ltd.) added to 0.2 units / mL). The biofilm inhibition rate was calculated by the following formula. The number of control biofilm (BF) bacteria is the number of viable bacteria without treatment with the drug. The results are shown in Table 1 (N = 2 average value).

  As is apparent from Table 1, pectinase contains antibacterial metal zinc, silver poorly water-soluble metal salt compound zinc oxide (water solubility 0.42 mg / 100 mL (18 ° C.)), silver oxide (water Solubility 1.74mg / 100mL (20 ° C), Encyclopedia of Chemistry (Kyoritsu Shuppan Co., Ltd.) and antibacterial zeolite supporting silver and zinc synergistically improve the antibacterial effect on biofilm-forming bacteria all right.

＊４：ペクチナーゼＸＰ−５３４（ナガセケムテックス（株）製）
＊５：酸化亜鉛（和光純薬（株）製）
＊６：酸化銀（和光純薬（株）製）
＊７：銀、亜鉛担持ゼオライト（商品名「ゼオミックＡＪ１０Ｎ」、シナネンゼオミ
ック（株）製 銀イオン含有率２．５％、亜鉛イオン含有率１４％）

* 4: Pectinase XP-534 (manufactured by Nagase ChemteX Corporation)
* 5: Zinc oxide (Wako Pure Chemical Industries, Ltd.)
* 6: Silver oxide (Wako Pure Chemical Industries, Ltd.)
* 7: Silver and zinc-supported zeolite (trade name “Zeomic AJ10N”, Sinanen Zeomi
Made by Cook Co., Ltd. Silver ion content 2.5%, zinc ion content 14%)

Example 11 Dentifrice Calcium Phosphate 25%
Silicic anhydride 5
Sodium lauryl sulfate 1.0
Myristic acid diethanolamide 0.6
Glycerin 20
Sodium carboxymethylcellulose 0.8
Carrageenan 0.5
Gelatin 0.8
Saccharin sodium 0.1
Pectinase ^{* 8} 0.05
Antibacterial zeolite ^{* 9} 0.2
Fragrance 1.0
Water balance <br/> Total 100%
* 8: Pectinase XP-534 (manufactured by Nagase ChemteX Corporation)
* 9: Silver and zinc-supported zeolite (trade name “Zeomic AJ10N”, manufactured by Sinanen Zeomic Co., Ltd.)

[Example 12] Dentifrice Silicic anhydride 15.0%
Sodium lauryl sulfate 1.0
Sorbitol 20.0
Xanthan gum 0.5
Sodium alginate 0.5
Saccharin sodium 0.1
Sodium monofluorophosphate 0.1
Pectinase ^{* 10} 0.1
Zinc oxide 0.05
Fragrance 1.0
Water balance <br/> Total 100%
* 10: Pectinase A “Amano” (Amano Enzyme Co., Ltd.)

[Example 13] Oral pasteacetanol 5.0%
Squalane 20.0
Precipitated silica 5.0
Polyoxyethylene (40) hydrogenated castor oil 0.1
Sorbitan monooleate 1.0
Sodium lauryl sulfate 0.2
Saccharin sodium 0.6
Pectinase ^{* 11} 0.05
Zinc oxide 0.2
Fragrance 0.6
Water balance <br/> Total 100%
* 11: Pectinex Ultra SP-L (manufactured by Novozymes Japan)

[Example 14] Mouthwash ethanol 10.0%
Pectinase ^{* 12} 0.2
Antibacterial zeolite ^{* 13} 0.05
Polyoxyethylene (60) hydrogenated castor oil 0.5
Sorbitan saccharin sodium 0.2
Xylitol 5.0
Fragrance 0.8
Water balance <br/> Total 100%
* 12: Pectinase SS (manufactured by Yakult Pharmaceutical Co., Ltd.)
* 13: Zeolite carrying silver and zinc (trade name “Zeomic AJ10N”, manufactured by Sinanen Zeomic Co., Ltd.)

[Example 15] Gum gum base 20.0%
Fragrance 1.0
Minamata 20.0
Sorbitol 20.0
Xylitol 10.0
Powdered sugar 20.0
Trisodium citrate 1.5
Pectinase ^{* 14} 0.1
Antibacterial zeolite ^{* 15} 1.0
Water balance <br/> Total 100%
* 14: Macero Team A (Yakult Pharmaceutical Co., Ltd.)
* 15: Silver and zinc supported zeolite (trade name “Zeomic AJ10N”, manufactured by Sinanen Zeomic Co., Ltd.)

Claims (3)

  An oral composition comprising pectinase and one or more antibacterial agents selected from a poorly water-soluble metal salt compound of an antibacterial metal and an antibacterial metal ion-carrying zeolite.   The composition for oral cavity according to claim 1, wherein the antibacterial metal is one or more metals selected from silver, zinc and copper.   The composition for oral cavity according to claim 1, wherein the antibacterial agent is one or more selected from zinc oxide, silver oxide, and silver and / or zinc-supported zeolite.