JP2006052230A - Dividable tablet and press-through pack - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To provide a dividable tablet and a press-through pack, especially a dividable tablet easily dividable in high accuracy without generating chipping, having excellent impact resistance and having a shape to prevent the twinning, etc., of tablets in a film-coating process and a press-through pack holding the dividable tablet. <P>SOLUTION: The dividable tablet has a dividing line formed along a center line on the upper surface of the tablet, and ridgelines each located on an inner side of the peripheral portion of the tablet to surround the dividing line in two areas defined by the dividing line on the upper surface of the tablet. The lower surface of the tablet gradually rises from the peripheral portion of the tablet toward the center portion, and areas around the ridgelines are each formed by a convex surface. <P>COPYRIGHT: (C)2006,JPO&NCIPI

Description

  The present invention relates to divided tablets and press-through packs, and in particular, can be divided easily and accurately without chipping, has excellent impact resistance, and does not cause twinning between tablets during the film coating process. A split tablet having a shape, and a press-through pack containing such a split tablet, and the split tablet contained in the press-through pack can be easily and easily stored in two in the state stored in the press-through pack. The present invention relates to a press-through pack that can be divided and collected in two at the same time.

Divided tablets are tablets that are divided by the pharmacist at the time of dispensing according to the dose, or by the patient himself at the time of taking, and are developed to optimize administration of doses for individual patients and increase the convenience of prescription Has been.
Such divided tablets are generally provided with a dividing line (dividing groove) for dividing the tablet.

FIG. 13 is a view schematically showing a conventional flat divided tablet, in which FIG. 13 (a) is a plan view, FIG. 13 (b) is a bottom view, and FIG. 13 (c) is a side view. , Respectively.
In the flat divided tablet Te, both the upper surface Sa and the lower surface Sb have a planar shape, and a dividing line Ld is formed along the center line on the upper surface Sa.
When dividing this divided tablet Te into two, each of the two regions R1 and R2 formed by the dividing line Ld on the upper surface Sa is grasped directly by a pharmacist or patient with fingers, and the dividing line Ld is obtained. The split tablet Te is divided along the secant Ld so as to be spread.
However, the split tablet Te shown in FIG. 13 has a problem that it is difficult to split the split tablet Te for an elderly person who has difficulty in splitting into two, and whose fingertip strength and sensation are reduced.

FIG. 14 is a diagram schematically showing a conventional karate-type divided tablet described in Patent Document 1, FIG. 14 (a) is a plan view, FIG. 14 (b) is a bottom view, and FIG. 14 (c) shows side views, respectively.
The karate-type tablet Tf has a lower surface Sb in a planar shape. In addition, the upper surface Sa is provided with a dividing line Ld along the center line, and each of the two regions R1 and R2 formed by the dividing line Ld on the upper surface Sa is a line Ld2 serving as a starting point of the dividing line Ld. , Ld2 has a flat surface provided so as to be gradually thickened in the peripheral direction of the tablet.
In this divided tablet Tf, when dividing into two, in addition to the method in which the pharmacist or patient, etc., directly grabs each of the two regions R1, R2 with the fingers and divides along the dividing line Ld, If the upper surface Sa provided with the dividing line Ld of the tablet Tf is turned down and the lower surface Sb is turned up and pushed downward from above, there is an advantage that it can be divided into two.

  By the way, the tablet may contain an ingredient having an unpleasant odor or taste as an active ingredient, or an ingredient that is not very stable with respect to light or the like, and a tablet containing such an active ingredient is effective. In order to mask the unpleasant odor and taste of the components and to ensure stability against light or the like, a film coat is generally applied.

However, since the upper surface Sa and the lower surface Sb of the conventional divided tablet Te are both flat, the tablets Te,... Are easily in surface contact with each other. For this reason, in the film coating process in which a film coat is applied to the surface of the tablet Te, there is a problem that the phenomenon that the tablets Te,...
Similarly, the conventional divided tablet Tf has a flat surface on each of the two regions R1 and R2 formed by the dividing line Ld on the upper surface Sa, and the lower surface Sb is formed on a flat surface. Tf, ... are easily in surface contact with each other. Therefore, when a film coat is applied to the surface of the tablet Tf, there is a problem that a phenomenon (so-called twinning) in which the tablets Tf,...

In addition, when film coating is applied to the conventional divided tablets Te and Tf, the strength of the tablet is enhanced by the film coating, so that a stronger force is required at the time of division or the division tends to be uneven. is there.
For example, the split tablet described in Patent Document 2 has already been proposed as a split tablet that is less likely to cause twinning in the film coating process and easily split into two when the film coat is applied. Yes.

FIG. 15 is a diagram schematically showing an example of a divided tablet described in Patent Document 2. FIG. 15 (a) is a plan view, FIG. 15 (b) is a bottom view, and FIG. Shows side views, respectively.
This divided tablet Tg is provided with a dividing line Ld along the center line on the upper surface Sa, and each of the two regions R1 and R2 formed by the dividing line Ld on the upper surface Sa is an origin of the dividing line Ld. Each of the lines Ld2 and Ld2 has an inclined plane that gradually increases in thickness in the peripheral direction of the tablet, and the lower surface Sb of the tablet Tg has an edge at the center C. It is a convex shape that rises from the part E.

Since this divided tablet Tg has a convex shape in which the lower surface Sb of the tablet Tg is raised so that the central portion C rises from the edge portion E, the tablet Tg,... More if you do. For this reason, twinning or the like hardly occurs during the film coating process.
In addition, when the tablet Tg is divided into two, in addition to the method in which the pharmacist or patient or the like grasps each of the two regions R1 and R2 directly with fingers and divides along the dividing line Ld, the tablet Tg Has an advantage that it can be divided into two if it is pushed downward from above.

FIG. 16 is a diagram schematically showing another example of the divided tablet described in Patent Document 2. FIG. 16 (a) is a plan view, FIG. 16 (b) is a bottom view, and FIG. (c) shows side views, respectively.
This divided tablet (lower curved type karate tablet) Th is provided with a dividing line Ld along the center line on its upper surface Sa, and two regions R1, R2 formed by the dividing line Ld on its upper surface Sa. Each has a concave shape that gradually increases in thickness in the peripheral edge E direction of the tablet Th from each of the lines Ld2 and Ld2 that are the starting ends of the dividing line Ld, and the lower surface Sb of the tablet Th is, The shape is a convex shape in which the central portion C rises from the edge portion E.

Similarly to the divided tablet Tg, this divided tablet Th has a convex shape such that the lower surface Sb of the tablet Th rises from the edge E so that the tablets Th,... It is configured to make point contact easier than contact.
Further, in this divided tablet Th, the shape of each of the two regions R1 and R2 formed by the dividing line Ld on the upper surface Sa is made concave so that the planar portion is eliminated from the surface of the tablet Th. Therefore, twinning is less likely to occur during the film coating process compared to the split tablet Tg.
In addition, when the tablet Th is divided into two, in addition to the method in which the pharmacist or patient or the like grasps each of the two regions R1 and R2 with fingers and divides along the dividing line Ld, the tablet Th Has an advantage that it can be divided into two if it is pushed downward from above.

By the way, tablets are generally contained in a press-through pack (generally referred to as PTP packaging) so as not to be contaminated by moisture, dust, mold, bacteria, or the like during storage.
FIG. 17 is a cross-sectional view schematically showing an example of such a press-through pack.
The press-through pack 101 includes a storage body 102 and a sealing sheet 103.
The storage body 102 is generally made of a synthetic resin such as polyvinyl chloride, polypropylene, or cyclic polyolefin, and is connected by plate-like portions 102a,..., 102a. It has a shape having a plurality of storage recesses 102b, ..., 102b formed according to the shape.
The sealing sheet 103 includes a base material 105 made of aluminum foil or the like, and an adhesive layer 104 provided on one surface of the base material 105.
The press-through pack 101 includes the adhesive layer 104 of the sealing sheet 103 and the storage body 102 in a state where the tablets T,..., T are stored in the storage recesses 102b,. The plate-like portions 102a,..., 102a are bonded to each other, and the storage body 102 is sealed with a sealing sheet 103.

In such a press-through pack 101, if each of the convex portions 102c, ..., 102c on the outside of the storage recesses 102b, ..., 102b of the storage body 102 is pressed, the storage recesses 102b, ... Each of the tablets T,..., T in which the portions r1,..., R1 of the sealing sheet 103 sealing each of the 102b are accommodated in the storage recesses 102b,. , And the tablets T,..., T can be taken out from the press-through pack 101 one by one.
When split tablets Te and Tf are stored in such a press-through pack 101, generally, the tablet is broken by the split tablets Te and Tf stored in the storage recesses 102b,. Then, the divided tablets Te and Tf are taken out one by one from the press-through pack 101, and then, if necessary, the divided tablets Te and Tf are divided into two by fingers by the pharmacist or the patient.
Further, according to Patent Document 2, when the divided tablets Tg, Th are stored in the press-through pack 101, the divided tablets Tg, Th are also removed before taking out the divided tablets Tg, Th from the press-through pack 101. There is a description that it can be divided into two.

Thus, if the divided tablets Tg, Th can be divided into two before being taken out from the press-through pack 101, the divided tablets Tg, Th can be divided into two when the divided tablets Tg, Th are divided into two. There is no need to grab it with your fingers. Thereby, when dividing the divided tablets Tg and Th into two, the situation that the tablets Tg and Th are contaminated by fingers does not occur.
However, split tablets Tg and Th are difficult to split into two when applying force in the vertical direction from top to bottom, and defective products occur in the tableting and coating processes. In addition, it cannot be said that the problem of easy handling is sufficiently solved, and the divided tablets Tg and Th are transported when they are pneumatically transported from one place to another, or when they are transported in a press-through pack 101 or bottling. There is a problem that chipping easily occurs.

For example, when the divided tablet Tg is to be divided by applying a force in the vertical direction from the upper side to the lower side (see FIG. 18 (a)), as shown in FIG. Since the edge portion Pe is sharp, the force concentrates on the sharp edge portion Pe, and the edge portion Pe may be crushed or chipped.
Further, the divided tablet Tg has a problem that capping is likely to occur at the sharp edge portion Pe in the tableting process.
Further, since each of the two regions R1 and R2 formed by the secant Ld on the upper surface Sa of the tablet Tg is a flat surface, the region R1 of a certain tablet Tg and the region R1 of a certain tablet Tg contact each other, or a certain tablet When the relationship between the region R1 of the Tg and the region R2 of the tablet Tg is in contact with each other, or the region R2 of the tablet Tg and the region R2 of the tablet Tg are in contact with each other, the tablet Tg and the tablet Tg are in contact with each other. In this case, since the tablets Tg, ... are in surface contact with each other, the problem that twinning occurs in the coating process is not solved.
In addition, since the edge portion Pe of the upper surface Sa of the tablet Tg is pointed, when the tablets Tg, ... collide with each other in the coating process, core erosion (a phenomenon that the uncoated tablet is worn away) or edge Chipping (a phenomenon in which the edge portion is missing) is likely to occur.
In addition, when tablets Tg, ... are pneumatically transported from one place to another, when they are pneumatically transported, tablets Tg, ... collide with each other, or tablets Tg, ... collide with the transport pipe. The edge portion Pe of the upper surface Sa of the tablet Tg is chipped, and the edge of the upper surface Sa of the tablet Tg due to the vibration that occurs during the transport when the press-through pack 101 is transported. There is a problem that the portion Pe collides with the storage main body 102 or the sealing sheet 103 to cause chipping or the sealing sheet 103 is broken by the edge portion Pe.
In addition, when bottled, tablets Tg, ... collide with each other or tablets Tg, ... collide with the bottle due to vibrations etc. that occur during transportation, and the edge portion Pe is missing. There is a problem such as.

Further, when the tablet Tg is stored in the press-through pack 101, the tablet Tg is provided in the storage recess 102b of the storage body 102 of the press-through pack 101, and the dividing line Ld of the tablet Tg is provided in the direction of the sealing sheet 103. When the upper surface Sa on the other side is facing (see the tablet Tg stored in the right storage recess 102b in FIG. 19 (a)), the storage recess of the storage body 102 of the press-through pack 101 is used. When the convex portion 102c to be 102b is pressed with a finger, the tablet Tg can be easily divided into two by pressing the convex central portion of the lower surface Sb of the tablet Tg with a finger (FIG. 19 (b ) (Refer to the tablet Tg stored in the right side storage recess 102b) However, on the contrary, the tablet Tg is stored in the storage recess 102b of the storage body 102 of the press-through pack 101. When the upper surface Sa on the side where the dividing line Ld of the tablet Tg is provided faces toward the 102 (stored in the storage recess 102b on the left side in FIG. 19 (a)) (Refer to agent Tg) When the convex portion 102c that becomes the storage recess 102b of the storage body 102 of the press-through pack 101 is pressed with a finger, the storage recess 102b is crushed into a V shape when viewed from the side. Since the shape of the two regions R1 and R2 formed by the dividing line Ld of the upper surface Sa of the tablet Tg is parallel to the shape of the finger Tg, the tablet Tg There is a problem that cannot be divided into two.

  Therefore, before taking out the tablet Tg from the storage recess 102b of the storage body 102 of the press-through pack 101, in order to be able to easily divide the tablet Tg into two, on the right side in FIG. As shown, the tablet Tg accommodated in each of the storage recesses 102b of the storage body 102 of the press-through pack 101 is provided with a dividing line Ld for the tablet Tg toward the sealing sheet 103. It is necessary to regulate the direction so that the upper surface Sa of the pressed side faces, but in this way, all the directions of the tablets Tg,... Are regulated in a certain direction, and the storage body 102 of the press-through pack 101 is stored. There is a problem that it is extremely difficult to realize in each of the recesses 102b,.

Moreover, even if all the tablets Tg,... Can be accommodated in each of the storage recesses 102b,... When each of Tg,... Is stored in each of the storage recesses 102b,... With the sealing sheet 103 facing the upper surface Sa on the side where the dividing line Ld of the tablet Tg is provided. Since the sharp edge portion Pe faces the direction of the sealing sheet 103, the sealing sheet 103 is easily broken by the sharp edge portion Pe without being pushed with a finger or the like.
Similarly to the divided tablet Tg, when the divided tablet Th is divided by applying a force in the vertical direction from the upper side to the lower side (see FIG. 20 (a)), the edge portion Pe of the upper surface Sa of the tablet Th However, since it is pointed, the force concentrates on this pointed edge part Pe, and the edge part Pe is crushed or chipped, etc., and it is difficult to divide into two parts (FIG. 20 (b) And capping is likely to occur at the sharp edge portion Pe in the tableting process.
Further, since the edge portion Pe of the upper surface Sa of the tablet Th is pointed, similarly to the divided tablet Tg, the tablets Th,... Damage phenomenon) and edge chipping (a phenomenon in which an edge portion is missing).

  Furthermore, when tablets Th,... Are pneumatically transported from one place to another, tablets Th,... Collide with each other, or tablets Th,. When the edge portion Pe of the upper surface Sa of the tablet Th is chipped or conveyed as a press-through pack 101, the edge portion Pe of the upper surface Sa of the tablet Th is caused to move into the storage body 102 due to vibration or the like generated during the conveyance. The tablet due to problems such as collision with the sealing sheet 103 and causing chipping, or the sealing sheet 103 being broken by the edge portion Pe, and vibration generated during transportation when bottled. There is a problem that the edges Pe are chipped when Th,... Collide with each other, or the tablets Th,.

Further, when the tablet Th is stored in the press-through pack 101, the tablet Th is provided in the storage recess 102b of the storage body 102 of the press-through pack 101, and the dividing line Ld of the tablet Tg is provided in the direction of the sealing sheet 103. When the upper surface Sa on the other side is facing (see the tablet Th stored in the right storage recess 102b in FIG. 21 (a)), the storage recess of the storage body 102 of the press-through pack 101 is used. When the convex portion 102c to be 102b is pressed with a finger, the tablet Th can be easily divided into two by pressing the convex central portion of the lower surface Sb of the tablet Th with a finger (FIG. 21 (b ) (Refer to the tablet Th stored in the right side storage recess 102b), but on the contrary, the tablet Th is stored in the storage recess 102b of the storage body 102 of the press-through pack 101. When the upper surface Sa on the side where the secant line Ld of the tablet Th is provided faces toward the 102 (stored in the storage recess 102b on the left side in FIG. 21 (a)) (See Agent Th), when the convex portion 102c that becomes the storage recess 102b of the storage body 102 of the press-through pack 101 is pressed with a finger, the storage recess 102b is crushed in a V shape when viewed from the side. Since the shape of the two regions R1 and R2 formed by the dividing line Ld of the upper surface Sa of the tablet Th is parallel to the shape of the finger Th, the tablet Th is 2 unless a considerable force is applied. There is a problem that it cannot be divided into two.

Further, in the case of the tablet Th, since each of the two regions R1, R2 formed by the secant Ld on the upper surface Sa is concave, it means that the tablets are in surface contact with each other like the divided tablet Tg. Since there is no twinning in the coating process compared to the divided tablet Tg, each of the two regions R1 and R2 formed by the dividing line Ld of the upper surface Sa of the tablet Th is a concave surface, so the dividing line Ld In the vicinity of the dividing line Ld of either of the two regions R1 and R2, the tablet Th is likely to break into two (see the split R11 in FIG. 20 (b)). .
Furthermore, when the divided tablets stored in the press-through pack are divided in the state stored in the press-through pack, the conventional press-through pack sheet is prepared on the assumption that the tablets are taken out one by one. The tablets divided into two must be taken out from each of the storage recesses 102b,..., And there is a problem that the operation of taking out the tablets divided into two from the press-through pack is troublesome.
JP 61-289027 JP-A-8-53345

The present invention was made to solve the above problems, and can be divided into two easily and accurately without restricting the direction with respect to the upper or lower surface of the tablet. It is an object of the present invention to provide a divided tablet which is less likely to be chipped at the time and / or at the time of transport and which does not cause problems such as twinning even when film-coated.
Furthermore, the present invention provides a press-through pack in which a pharmacist or patient can easily divide a divided tablet at once without touching it with fingers and easily and easily collect a tablet divided into two. The purpose is to provide.

The present invention relates to the following (1) to (9).
(1) a secant formed along the center line on the upper surface of the tablet;
In each of the two regions formed by the secant on the upper surface of the tablet, a ridge line so as to surround the secant and to be located inside the edge of the tablet,
Provided on the lower surface of the tablet with a shape gradually rising from the edge of the tablet toward the center, and
The divided tablet which comprised each ridgeline periphery area | region of the said two ridgelines with the convex-shaped curved surface.
(2) Each of the two regions formed by the secant on the upper surface of the tablet, the shape of the surface from each of the lines that are the starting edge of the secant to each of the two ridge lines is a convex curved surface The divided tablet according to (1), which is constituted.
(3) The divided tablet according to (1) or (2), wherein the secant is formed by a groove deeper than the upper surface of the edge of the tablet.
(4) The divided tablet according to any one of (1) to (3), wherein the score line is a V-groove or a U-groove.
(5) Each of the lines serving as the starting ends of the dividing line is provided at a position above the upper surface of the edge of the tablet, according to any one of (1) to (4), Split tablet.
(6) The division according to any one of (1) to (5) above, wherein the shape from each of the two ridges on the upper surface of the tablet to the edge of the tablet is a steep slope. tablet.
(7) The divided tablet according to (6) above, wherein the steep slope is a straight or convex curve when viewed in cross section.
(8) The dividing line is chamfered in two convex shapes formed so as to sandwich each of the dividing lines in the vicinity of the intersection with the edge of the tablet. (7) The divided tablet according to any one of
(9) A storage body having a plurality of storage recesses connected by a plate-like portion, a base material, and a sealing sheet having an adhesive layer provided on one surface of the base material,
In the state where the divided tablets according to any one of (1) to (8) are housed in each of the plurality of housing recesses of the housing body, the adhesive layer of the sealing sheet and the plate shape of the housing body And the storage body is sealed by the sealing sheet,
When the sealing sheet is pressed by a finger with a convex portion that is outside the storage recess storing the divided tablet according to any one of (1) to (8), the adhesive layer of the sealing sheet and the storage In the bonding portion with the plate-like portion of the main body, without causing floating or peeling, the portion of the sealing sheet that seals the housing recess is broken, and any one of the above (1) to (8) The described divided tablets can be taken out, and
A press-through pack adhered to a plate-like portion of the storage body so that the storage body can be easily peeled off.

The divided tablet of (1) includes a dividing line formed along the center line on the upper surface of the tablet and two regions formed by the dividing line on the upper surface of the tablet so as to surround the dividing line and the edge of the tablet A ridge line so as to be located on the inner side and a shape gradually rising from the edge of the tablet toward the center part are provided on the lower surface of the tablet, and each of the ridge line peripheral areas of the two ridge lines is convex. It was composed of curved surfaces.
In this divided tablet, when the ridge line is formed in each of the two regions formed by the dividing line on the upper surface of the tablet, each peripheral region of the two ridge lines is constituted by a convex curved surface, and the upper surface of the tablet Since the sharp edge portion is eliminated, when a force is applied from the upper side to the lower side of the tablet, the tablet can be neatly divided along the dividing line without causing any chipping. In addition, chipping of the tablets is unlikely to occur during the tableting process, pneumatic transportation, or when transported in a press-through pack or bottling.

In addition, since the sharp edge from the upper surface of the tablet is eliminated, core erosion, edge chipping, and the like are unlikely to occur in the coating process.
In addition, since the sharp edge from the upper surface of the tablet is eliminated, when the tablet is accommodated in the storage recess of the press-through pack, the sealing sheet can be used without any need to press it with fingers. It is unlikely to break.

The divided tablet of (2) is divided from each of the two regions formed by the dividing line on the upper surface of the divided tablet of (1) to each of the two ridge lines. The shape of this surface is a convex curved surface.
Here, in each of the two regions, the “convex curved surface” of the shape of the surface from each of the lines serving as the starting point of the dividing line to each of the two ridge lines is a gently raised curved surface.
More specifically, the curvature of each surface of each of the two regions continuously changes from a surface having a low curvature to a surface having a large curvature in a ridgeline direction from the starting line of the secant line. By doing so, it becomes a gentle raised curved surface as a whole.

In this divided tablet, since the bottom surface of the tablet has a shape that gradually rises from the edge of the tablet toward the center, the tablet is placed in the storage recess of the storage body of the press-through pack and toward the sealing sheet. When the upper surface on the side where the score line is provided is facing, when the convex part that is the storage recess of the storage body of the press-through pack is pressed with a finger, the convex center part of the lower surface of the tablet is pressed with the finger. By pressing, the tablet can be easily divided into two.
In addition, since the shape of the surface from each of the starting lines of the dividing line to each of the two ridge lines is configured by a convex curved surface, the dividing line of the tablet is provided in the storage recess of the press-through pack. When the convex part of the press-down pack storage recess is pressed with a finger even when the side is stored facing the storage body, the storage recess or finger is crushed in a V shape when viewed from the side. Since each of the two regions formed by the dividing line on the upper surface of the tablet has a curved surface facing each other, the force acts on the tablet in the direction of opening the dividing line without applying force to the finger. Thereby, even when the side where the score line of the tablet is provided is stored in the storage recess of the press-through pack so as to face the storage body, the tablet can be easily divided into two.

Thus, in this divided tablet, even if the tablet is stored in the storage recess of the storage body of the press-through pack without restricting the direction, it is divided into two before taking out the tablet from the press-through pack. Can do.
Further, since this divided tablet has two convex surfaces on the upper surface and a convex surface on the lower surface, the tablets do not make surface contact but make point contact. Thus, twinning is unlikely to occur in the coating process.

The divided tablet of (3) is characterized in that the dividing line of the divided tablet of (1) or (2) is formed with a deeper groove than the upper surface of the edge of the tablet.
Here, the term “deep groove” used in the present invention means a groove whose deepest part is located below the edge of the upper surface of the tablet.
More specifically, the vertical distance from the top of the tablet to the deepest part of the secant has a shorter relationship than the vertical distance from the top of the tablet to the top of the edge of the tablet. Means that.
In this divided tablet, since the dividing line of the tablet is formed deeper than the dividing line of a normal divided tablet, it can be divided neatly along the dividing line.

The divided tablet of (4) is characterized in that the dividing line of the divided tablets of (1) to (3) is a V groove or a U groove.
Here, the term “V-groove” used in the present specification means the case of a V-groove and a substantially V-groove. The “substantially V-groove” is, for example, a shape in which the vicinity of the apex angle of the V-groove is a rounded curve, a shape around the top of a parabola (secondary curve), or the top of the V-groove. This includes a case where the rounded curved portion in the vicinity of the corner has a polygonal shape having a bent portion.
In addition, the term “U-groove” used in the present specification means a U-groove and a case where it is a substantially U-groove. The “substantially U-groove” includes, for example, a case where the round curved portion of the U-groove has a polygonal shape having a bent portion.
In this divided tablet, the shape of the surface forming the dividing line is a flat surface or a concave surface, and is different from the convex shape of each of the two regions from the line that is the starting edge of the dividing line to each of the ridge lines.
Since the dividing line is a V-groove or a U-groove, the tablet thickness from the deepest part of the dividing line to each of the lines that become the starting edge of the dividing line is gradually and gradually increased in the case of the V-groove. In the case of the groove, in the dividing line region, the thickness gradually increases from the deepest part of the dividing line to each of the lines that are the starting ends of the dividing lines, and rapidly increases in the vicinity of each of the lines that are the starting ends of the dividing lines.

On the other hand, since the surface from each of the two lines from the starting line of the dividing line to each of the ridge lines has a convex shape, the starting line in each direction of the ridge line from the line from which the dividing line starts. At each position near the end line, the tablet thickness suddenly increases.
Thus, in this divided tablet, the change in the thickness of the tablet in the dividing line area, and the respective positions in the vicinity of the starting line in the respective directions of the ridge line from the starting line of the dividing line. The thickness of the tablet at each position near the starting line in each direction of the ridge line from the starting line of the secant line The force acting from the outside of the tablet per unit volume is large in the dividing line area, and in the vicinity of the starting line in each direction of the ridge line from the starting line of the dividing line Since the force acting from the outside of the tablet per unit volume in the secant area is smaller at each position of the tablet, the tablet can be neatly divided according to the dividing line when divided into two.

In the divided tablet of (5), each of the line portions that are the starting ends of the dividing lines of the divided tablets of (1) to (4) is provided at a position above the upper surface of the edge of the tablet. It is characterized by.
Here, “the line that is the starting point of the dividing line” means two lines that are the starting points of the dividing line.
The “position above the upper surface of the edge of the tablet” more specifically refers to the position on the surface of each of the two surfaces from each of the lines that are the starting edge of the dividing line to each of the two ridge lines. means.
Dividing tablets can be easily divided into two by increasing the dividing line (depth of the dividing line), but when increasing the dividing line (deepening of the dividing line depth), the tablet can be moved vertically from the top of the tablet to the tablet. If the secant line is formed deeply, the mechanical strength of the tablet will be weakened in the area where the secant line is provided, and the tablet will be divided into two parts even though it is not intended to be divided. There is a problem that it becomes easy.

In this divided tablet, the starting line of the dividing line is not formed on the upper surface of the tablet, but is provided at a position above the upper surface of the edge of the tablet. The dividing line can be made large (the depth of the dividing line can be increased) without forming.
As a result, as in the case where a secant line is formed deeply in the longitudinal direction from the upper surface of the tablet to the tablet, the secant line is increased in the region where the secant line is provided without decreasing the mechanical strength of the tablet (the depth of the secant line is increased). It is easy to divide into two, and when the tablet is not intended to be divided, the tablet will not be divided into two without permission. Can do.

The divided tablet of (6) is characterized in that the shape of each of the divided tablets of (1) to (5) from each of the two ridges on the upper surface of the tablet to the edge of the tablet is a steep slope. And
In this divided tablet, the shape from each of the two ridge lines on the upper surface of the tablet to the edge of the tablet is a steep slope, and the shape from the line that becomes the starting edge of the dividing line on the upper surface of the tablet to the ridge line is divided into two Compared to the shape from each of the ridge lines to the edge of the tablet, it has a gentle bulge curve. Therefore, when a force is applied to the tablet from the top to the bottom, the force is easily applied in the direction of opening the dividing line. Thereby, it can divide neatly along a secant with a small force.

The divided tablet of (7) is characterized in that the steep slope of the divided tablet of (6) is a straight or convex curve when viewed in cross section.
In this divided tablet, the vicinity of the two ridge lines formed on the upper surface of the tablet is not a sharp edge portion, is constituted by a convex curved surface, and when a force is applied to the tablet from the top to the bottom, To make it easier to apply a force in the direction of opening the secant line, the shape from the starting line of the dividing line on the upper surface of the tablet to the ridge line should be a gentle bulge curve as far as possible from the ridge line on the upper surface of the tablet to the edge of the tablet. The shape of the inclined surface with a steep shape up to the portion may be a straight or convex curved line as long as it is not concave when viewed in cross section.

Therefore, whether the shape of the steep slope from the ridge line on the upper surface of the tablet to the edge of the tablet is a straight or convex curve may be determined from the design of the tablet.
Therefore, the shape of the tablet can be produced so that the shape of the tablet can be impressed by a doctor, a pharmacist, a patient or the like based on the medicinal effect, efficacy, effect, etc. of the divided tablet.

The divided tablet of the above (8), the divided tablet of the above-mentioned divided tablets of (1) to (7), two convex shapes formed so that each of the regions in the vicinity of the intersection with the edge of the tablet sandwiches the dividing line It is characterized by being chamfered.
In this divided tablet, each region near the intersection that intersects the edge of the tablet is chamfered into two convex shapes formed so as to sandwich the dividing line, so that the tablet is less likely to be chipped.
The divided tablets of (1) to (8) may be plain tablets (bare tablets) or may be those with an appropriate coating such as a film coat or sugar coating on the surface.

Moreover, the divided tablets of (1) to (8) may contain an excipient, a binder, a disintegrant, and a lubricant as the case may be, in addition to the active ingredient. Furthermore, if necessary, a sweetener, a coloring agent, a flavoring agent, an antioxidant and the like may be added to prepare a formulation.
Such a divided tablet can be produced by, for example, a compression molding method.
As the compression molding method, the mixed powder may be directly compressed, and the powder is granulated into a granulated product having a predetermined particle size and particle size distribution in a dry or wet manner, followed by a drying step and a sizing step. Alternatively, a granule or fine granule may be prepared, and a small amount of lubricant may be mixed with the granule or fine granule, followed by compression molding to form a tablet.

  None of the divided tablets of the above (1) to (8) has a sharp portion, so that sticking, laminating, capping and the like are unlikely to occur in the tableting process. It can be manufactured by continuous tableting using not only a machine but also a rotary tableting machine.

The lubricant may be added in advance to the active ingredient, excipient, etc., and the kneaded product of the active ingredient, excipient, etc. and the lubricant may be tableted (this Such a tablet production method is referred to as an internal lubrication method), and it is not added to active ingredients, excipients, etc. The kneaded product of the active ingredient, excipient, etc. may be tableted using a pestle or mortar having a lubricant layer on the surface (the method for producing such a tablet is called an external lubricant method). )
As a coating method, various coating methods can be used as long as they are conventional coating methods. For example, a pan (or drum) coating method, a fluid coating method, or the like can be used.
The film pressure of such a coating is not particularly limited, but is preferably 10 μm or more and 50 μm or less.

Various excipients can be used, and are not particularly limited. For example, sugars such as lactose, mannitol, sucrose, and glucose, potato starch, corn starch, and partially pregelatinized starch Any known materials such as starches such as precipitated calcium carbonate, calcium phosphate, sodium chloride and inorganic salts such as sodium chloride and crystalline cellulose can be used.
The excipient is generally contained in the range of 10 to 95 parts by weight per tablet.

Various binders can be used and are not particularly limited. For example, partially saponified polypinyl alcohol, hydroxyprocellulose, hydroxypropylmethylsetulose, polyvinylpyrrolidone, pullulan, methylcellulose, Any known materials such as gum arabic and starch can be used.
The binder is generally contained in the range of 0.5 to 5 parts by weight per tablet.

Various disintegrators can be used, and are not particularly limited. For example, crospovidone, low-substituted hydroxypropylcellulose, croscarmellose sodium, carboxymethylcellulose, carboxymethylcellulose calcium, carboxymethyl Any known substance such as sodium starch or partially pregelatinized starch hydroxypropyl starch can be used, but crospovidone, low-substituted hydroxypropylcellulose, and croscarmellose sodium are preferred.
Note that the disintegrant is contained in one tablet in the range of 1 to 15 parts by weight.

Examples of lubricants used for tableting include magnesium stearate, calcium stearate, zinc stearate, stearic acid, talc, hydrogenated vegetable oil, talc, etc., preferably magnesium stearate and calcium stearate. .
In addition, the lubricant is generally contained in the range of 0.01 to 5 parts by weight in one tablet.

The press-through pack of (9) is a sealing sheet having a storage body having a plurality of storage recesses connected by plate-like portions, a base material, and an adhesive layer provided on one surface of the base material The adhesive layer of the sealing sheet and the plate-like portion of the storage body are bonded to each of the plurality of storage recesses of the storage body in a state where the divided tablets of (1) to (8) are stored. The storage body is sealed with a sealing sheet, and the sealing sheet is sealed when a convex portion that is outside the storage recess storing the divided tablets of (1) to (8) is pressed with a finger. In the adhesive portion between the adhesive layer and the plate-like portion of the storage body, the portion of the sealing sheet sealing the storage recess is broken without causing floating or peeling, and the above (1) to (8) Can be taken out and adhered to the plate-like part of the storage body so that it can be easily peeled off from the storage body It has been.

Here, “adhered to the plate-like portion of the storage main body so that it can be easily peeled off from the storage main body” will be described in more detail when the part of the sealing sheet of the press-through pack is turned up. It means that the sheet is bonded so that it can be easily peeled off from the plate-like portion of the storage body without breaking.
In this press-through pack, it is sufficient that one or more of the divided tablets (1) to (8) are stored in any of the storage recesses of the storage body.
Moreover, the divided tablet accommodated in one of the storage recesses of the storage body may be stored in the storage recess so that the surface where the dividing line of the divided tablet is provided faces the storage body side. It may be stored so that the surface opposite the surface provided with the score line of the tablet faces the storage body side, and further, the surface provided with the score line of the divided tablet is stored so as to face the storage body side. Stored in each of the storage recesses of the storage body so that both the storage surface and the surface facing the surface where the dividing line of the divided tablet is placed face the storage body. May be.

In addition, the adhesive strength between the sealing sheet of this press-through pack and the plate-like part of the storage body is 0.9N / 15mm width or more and 3.1N / 15mm width or less when the T peel test is performed at a peel speed of 200mm / min. It is preferable that it is 1.9 N / 15 mm width or more and 2.7 N / 15 mm or less.
Further, when the T peel test is performed at a peel speed of 100 mm, it is preferably 4.2 N / 15 mm width or more and 7.0 N / 15 mm or less, preferably 4.8 N / 15 mm or more and 6.5 N / 15 mm width or less. More preferred.
Here, the unit “N / 15 mm width” used in this specification is to bond the storage body and the sealing sheet, and then cut the adhesive part between the storage body and the sealing sheet to a width of 15 mm, which is used as a test sample. Means the peel strength when the T peel test is conducted.

Also, the term “T peel test” used in this specification is JIS
It means the test according to K6845.
If it is within the above range, the convex part which is the outer surface of the storage recess storing the divided tablets of the storage main body is pushed out with the finger toward the sealing sheet, and the part sealing the storage recess of the sealing sheet is broken. When taking out the divided tablets, in the adhesive part between the adhesive layer of the sealing sheet outside the area of the storage recess (so-called pocket) where the divided tablets of the sealing sheet were taken out and the plate-like part of the storage body, When the sealing sheet is not peeled off or floated between the storage body and the sealing sheet, and the sealing sheet is peeled and turned up, the sealing sheet can be peeled off from the storage body without breaking the sealing sheet.

  On the other hand, below the above range, when the sealing sheet is peeled and turned up, the sealing sheet can be peeled off from the storage main body without breaking the sealing sheet, but the storage containing the divided tablets of the storage main body is stored. When the convex part which becomes the outer surface of the recess is pushed out with the finger in the direction of the sealing sheet, the sealing sheet is broken to take out the divided tablet, the outer side of the area of the storage recess where the divided tablet of the sealing sheet is taken out In the adhesive part between the adhesive layer of the sealing sheet and the plate-like part of the storage body, peeling or floating occurs between the storage body and the sealing sheet, which is not preferable.

  In addition, when exceeding the above range, when the convex portion which is the outer surface of the storage recess storing the divided tablet of the storage body is pushed out by the finger in the direction of the sealing sheet, the sealing sheet is broken to take out the divided tablet, No peeling or floating occurs between the storage body of the sealing sheet and the sealing sheet at the adhesive portion between the adhesive layer of the sealing sheet outside the storage recess from which the divided tablets are taken out and the plate-like portion of the storage body. However, it is difficult to peel off the sealing sheet and peel off the sealing sheet from the storage body. If the sealing sheet is forcibly peeled off, a part of the sealing sheet is broken, which is not preferable.

Here, the “adhesive component” means an adhesive used for normal heat sealing and cold sealing.
In addition, the “adhesive strength reducing component” means a component having an action of weakening the adhesive strength of the adhesive component, and means an adhesive having a weak adhesive strength, usually used as a release agent, a filler, etc. Examples thereof include resins used as mold release agents such as silicone resins and fluororesins. Moreover, when the storage main body is made of polyvinyl chloride, an acrylic resin can be used as the adhesive strength reducing component.
Examples of the filler include fine powders such as silicon oxide, magnesium silicate, titanium dioxide, zinc white, calcium carbonate, alumina, and talc.

  In this press-through pack, by adding an appropriate amount of adhesion-reducing component to the adhesive component, the adhesive strength of the adhesive is increased, and the convex portion that is the outer surface of the storage recess storing the divided tablets of the storage body is placed in the sealing sheet direction. When the solid sheet is taken out by pushing with a finger to break a part of the sealing sheet, the sealing sheet is sealed in the outer portion of the storage recess (so-called pocket) area from which the solid substance has been removed. The sheet does not peel or float between the storage body and the sealing sheet, and when the part of the sealing sheet is peeled off from the storage body, the sealing sheet does not break, and the sealing sheet does not break. The adhesive strength can be adjusted.

In the press-through pack of the present invention, the adhesive layer of the sealing sheet may be partially coated on the surface on one side of the sealing sheet.
Various methods can be considered as the method of “partial coating”. As long as it is possible to completely seal the divided tablets accommodated in the storage recesses of the storage body, it is opposed to the storage body of the sealing sheet. The adhesive may be applied to the surface on the side to be knitted or linear, or may be applied in combination of at least two of these.

This press-through pack is partially coated with an adhesive, so that the adhesive strength of the adhesive is pressed with the fingers on the outer surface of the storage recess containing the divided tablets, and a part of the sealing sheet is broken. When the solid material is taken out, when the so-called outer side of the pocket does not cause the storage body and the sealing sheet to peel off or float, and when a part of the sealing sheet is peeled off from the storage body, the sealing sheet The sealing sheet is adjusted so that the sealing sheet can be peeled off from the storage body without breaking.
Therefore, this press-through pack can take out the divided tablets stored in the press-through pack at a time by taking out the divided tablets one by one from the storage recess or by peeling the sealing sheet from the storage body. it can.

Furthermore, since the divided tablets of (1) to (8) are accommodated in each of the storage recesses of the press-through pack, each of the storage recesses is not restricted in the direction of the divided tablets. Even when a divided tablet is stored, it is easy and easy to remove two divided tablets before taking out the divided tablet from the storage recess by pushing the convex part outside the storage recess storing the divided tablet with a finger. Can be divided into
Therefore, before taking out the divided tablet from the storage recess, the divided tablet can be easily and simply divided into two, and then the divided tablet can be taken out from the storage recess.
Furthermore, the divided tablets stored in each of the storage recesses of the press-through pack can be easily and easily divided into two before taking out the divided tablets from the storage recesses, and then from the storage main body. By peeling off the sealing sheet, the tablet divided into two contained in this press-through pack can be taken out at once.

In the divided tablet of the above (1), when the ridge line is formed in each of the two regions formed by the dividing line on the upper surface of the tablet, each of the two ridge line peripheral regions is constituted by a convex curved surface, Since the sharp edge from the upper surface of the tablet is eliminated, when a force is applied from the upper side to the lower side of the tablet, the tablet can be neatly divided along the dividing line without causing chipping. In addition, chipping of tablets is unlikely to occur during the tableting process, pneumatic transportation, and when transported in a press-through pack or bottling.
In addition, since the sharp edge from the upper surface of the tablet is eliminated, core erosion, edge chipping, and the like are unlikely to occur in the coating process.
Further, since the sharp edge from the upper surface of the tablet is eliminated, when the tablet is stored in the storage recess of the press-through pack, it is difficult for the sealing sheet to be arbitrarily broken by the tablet.

In the divided tablet of the above (2), the bottom surface of the tablet has a shape that gradually rises from the edge of the tablet toward the center, so that the sealing sheet is placed in the storage recess of the storage body of the press-through pack. In addition, when the upper surface on the side on which the score line of the tablet is facing is facing, when the convex portion serving as the storage recess of the storage body of the press-through pack is pressed with a finger, the convex center of the lower surface of the tablet By pressing the part with a finger, the tablet can be easily divided into two.
And since the shape of the surface from the line that becomes the starting edge of the dividing line to each of the two ridge lines is constituted by a convex curved surface, the side where the dividing line of the tablet is provided in the storage recess of the press-through pack, Even when the storage body is stored facing toward the storage body, when the convex part of the storage recess of the press-through pack is pressed with a finger, the storage recess or finger shape is generally crushed into a V shape when viewed from the side. In addition, since each of the two regions formed by the dividing line on the upper surface of the tablet has a curved surface facing each other, compared to the conventional divided tablet, the tablet can be opened in the direction to open the dividing line without applying force to the finger. Power works. Thereby, even when the side where the score line of the tablet is provided is stored in the storage recess of the press-through pack so as to face the storage body, the tablet can be easily divided into two.

Thus, in this divided tablet, even if the tablet is stored in the storage recess of the storage body of the press-through pack without restricting the direction, it is divided into two before taking out the tablet from the press-through pack. Can do. Thereby, before taking out the divided tablet from the storage recess of the press-through pack, it is possible to realize a press-through pack in which the divided tablet stored in the storage recess can be easily divided into two.
Further, since this divided tablet has two convex surfaces on the upper surface and a convex surface on the lower surface, the tablets do not make surface contact but make point contact. Thus, twinning is unlikely to occur in the coating process.

  In the divided tablet of (3) above, the dividing line of the tablet is formed deeper than the dividing line of a normal divided tablet, so that it can be neatly divided along the dividing line.

  In the divided tablet of the above (4), in the secant region, the change in the thickness of the tablet, and the respective positions in the vicinity of the starting line in each direction of the ridge line from the starting line of the dividing line The thickness of the tablet at each position near the starting line in each direction of the ridge line from the starting line of the secant line The force acting from the outside of the tablet per unit volume is large in the dividing line area, and in the vicinity of the starting line in each direction of the ridge line from the starting line of the dividing line Since the force acting from the outside of the tablet per unit volume in the secant area is smaller at each position of the tablet, the tablet can be neatly divided according to the dividing line when divided into two.

  In the divided tablet of the above (5), the line that is the starting edge of the dividing line is not formed on the upper surface of the tablet, but is provided at a position above the upper surface of the edge of the tablet. The secant can be enlarged (the depth of the secant is increased) without forming a secant in the direction. As a result, as in the case where a secant line is formed deeply in the longitudinal direction from the upper surface of the tablet to the tablet, the secant line is enlarged (the secant line depth is increased) without decreasing the mechanical strength of the tablet. It is easy to divide into two parts, and if the tablet is not intended to be divided, the tablet will not be divided into two parts. Can do.

  In the divided tablet of the above (6), the shape from each of the two ridge lines on the upper surface of the tablet to the edge of the tablet is a steep slope, and the shape from the line to the ridge line that is the starting point of the dividing line on the upper surface of the tablet Compared to the shape from each of the two ridges to the edge of the tablet, it has a gentle bulge curve, so if a force is applied to the tablet from the top to the bottom, the force is likely to be applied in the direction to open the dividing line. . Thereby, it can divide neatly along a secant with a small force.

  In the divided tablet of (7), whether the shape of the steep slope from the ridge line on the upper surface of the tablet to the edge of the tablet is a straight or convex curve may be determined from the tablet design surface. . Therefore, the shape of the tablet can be produced so that the shape of the tablet can be impressed by a doctor, a pharmacist, a patient or the like based on the medicinal effect, efficacy, effect, etc. of the divided tablet.

  In the divided tablet of (8), each of the regions near the intersection that intersects the edge of the tablet is chamfered into two convex shapes formed so as to sandwich the dividing line, and therefore, the tablet is less likely to be chipped.

The press-through pack of the above (9) is a part of the sealing sheet by adjusting the adhesive so that the adhesive strength of the adhesive is pressed with a finger on the outer surface of the storage recess storing the divided tablets with a finger. When the solid body is taken out by breaking, the so-called outer side of the pocket does not cause the storage body and the sealing sheet to peel off or float, and when a part of the sealing sheet is peeled off from the storage body, The sealing sheet is adjusted so that the sealing sheet can be peeled off from the storage body without breaking the sealing sheet.
Therefore, this press-through pack can take out the divided tablets stored in the press-through pack at a time by taking out the divided tablets one by one from the storage recess or by peeling the sealing sheet from the storage body. it can.
Furthermore, since the divided tablets of (1) to (8) are accommodated in each of the storage recesses of the press-through pack, each of the storage recesses is not restricted in the direction of the divided tablets. Even when a divided tablet is stored, it is easy and easy to remove two divided tablets before taking out the divided tablet from the storage recess by pushing the convex part outside the storage recess storing the divided tablet with a finger. Can be divided into

Therefore, before taking out the divided tablet from the storage recess, the divided tablet can be easily and simply divided into two, and then the divided tablet can be taken out from the storage recess.
Furthermore, the divided tablets stored in each of the storage recesses of the press-through pack can be easily and easily divided into two before taking out the divided tablets from the storage recesses, and then from the storage main body. By peeling off the sealing sheet, the tablet divided into two contained in this press-through pack can be taken out at once.
Therefore, if this press-through pack is adopted, the dispensing operation in a hospital or the like can be greatly simplified.

Hereinafter, the divided tablet and the press-through pack according to the present invention will be described in more detail with reference to the drawings.
FIG. 1 is a diagram schematically showing an example of a divided tablet according to the present invention. FIG. 1 (a) is a plan view, FIG. 1 (b) is a bottom view, and FIG. 1 (c) is a side view. Each figure is shown.

As shown in FIG. 1 (a), the divided tablet Ta has a circular shape in plan view, and a dividing line Ld is provided on the upper surface Sa along the center line.
The shapes of the two regions R1 and R2 formed by the dividing line Ld on the upper surface Sa of the tablet Ta have a mirror image shape with the dividing line Ld interposed therebetween.
The secant Ld continues from one edge e1 of the tablet Ta to the other edge e2 on the opposite side of the one edge e1, and forms a deep groove.
More specifically, in this tablet Ta, as shown in FIGS. 1 (a) and 1 (c), the secant Ld has a V-groove shape.
In consideration of the crackability of the dividing line Ld, the apex angle θ of the V groove constituting the dividing line Ld is preferably in the range of 40 degrees or more and 90 degrees or less, more preferably 45 degrees or more and 90 degrees. It is preferably in the range of 50 degrees or less and more preferably in the range of 50 degrees or more and 60 degrees or less.
Note that the position H2 in the vertical direction of the line Ld2 (the Y-axis direction shown in FIG. Any position may be used as long as the relationship is higher than the position H1 in the vertical direction (Y-axis direction shown in FIG. 1C).

However, in consideration of the ease of cracking of the tablet Ta and the like, it is preferable that the tablet Ta is at a position higher than the position H3 in the vertical direction of the edge E of the upper surface Sa.
Further, the vertical position H1 of the deepest part Ld1 of the dividing line Ld may be located above the position H3 of the edge E of the upper surface Sa of the tablet Ta, but considering the ease of division of the tablet Ta, etc. In this case, it is preferable that the position H1 in the vertical direction of the deepest part Ld1 of the dividing line Ld is located below the position H3 of the edge E of the upper surface Sa of the tablet Ta.
More specifically, the vertical distance Y3 from the vertex of the bottom surface of the tablet Ta (vertex A5 shown in FIG. 1 (c)) to the deepest portion Ld1 of the secant Ld is determined from the vertex A5 of the bottom surface of the tablet Ta to the tablet. It is preferable that the relationship is shorter than the vertical distance Y1 to the upper surface Sa of the edge E of Ta.
The divided tablet Ta can be easily divided into two if the dividing line Ld is made larger (the deepest part Ld1 of the dividing line Ld is deeper), but the deepest part Ld1 of the dividing line Ld is more than the position H3 on the upper surface Sa of the tablet Ta. When deeply formed in the vertical direction (Y-axis direction shown in FIG. 1 (c)) in the direction of the bottom surface Sb of the tablet Ta, the mechanical strength of the tablet Ta is weakened, and it is not necessary to divide it. It becomes easy to be divided into two.
In order to solve such a problem, the position of the deepest portion Ld1 of the dividing line Ld is not located at a position much deeper than the position H3 of the upper surface Sa of the tablet Ta, and the position of the line Ld2 that is the starting point of the dividing line Ld It is preferable to increase the dividing line Ld by providing A2 and A2 at a position higher than the position H3 of the upper surface Sa of the tablet Ta.

In each of the two regions R1, R2 formed by the dividing line Ld of the upper surface Sa of the tablet Ta, the ridgelines L1, L2 so as to surround the dividing line Ld and to be located inside the edge E of the tablet Ta Is provided.
Each of the ridge line peripheral regions RL1 and RL2 of each of the ridge lines L1 and L2 is formed of a convex curved surface so as not to have a sharp edge portion.
Of the two regions R1 and R2, the ridge line L1 formed in the region R1 is a gentle bulge curve (convex curve) formed from the line Ld2 that is the starting point of the dividing line Ld, and the edge of the tablet Ta On the part E side, a convex curved surface formed by a steep slope R3 formed on the upper surface Sa of the tablet Ta along the edge E of the tablet Ta is combined. The ridge line peripheral region RL1 of the ridge line L1 is formed of a convex curved surface.

Here, the gentle uplift curve (convex curve) formed from the line Ld2 that is the starting point of the dividing line Ld in the region R1 will be described more specifically.The surface of the region R1 is the origin of the dividing line Ld. By gradually changing the curvature from a surface having a small curvature to a surface having a large curvature in the direction from the line Ld2 to the edge to the ridge line L1, the entire surface becomes a gently raised surface.
The steep slope R3 and the raised curved surface of the region R1 or the region R2 are joined at the top of the ridge line L1 or near the top, but the steep slope R3 and the raised curved surface of the region R1 or the region R2 are connected via a plurality of curved surfaces. It may be done.

In addition, the ridge line L2 formed in the region R2 out of the two regions R1 and R2 is a gentle bulge curve (convex-shaped curve) formed from the line Ld2 serving as the starting point of the dividing line Ld, and the tablet. On the edge E side, it is configured by combining a convex curved surface formed by a steep slope R4 formed on the upper surface Sa of the tablet Ta along the edge E of the tablet Ta, and The ridge line peripheral region RL2 of the ridge line L2 is also formed of a convex curved surface.
Here, the gentle uplift curve (convex curve) formed from the line Ld2 that is the starting point of the dividing line Ld in the region R2 will be described more specifically.The surface of the region R2 is the origin of the dividing line Ld. By gradually changing the curvature from a surface having a small curvature to a surface having a large curvature in the direction from the line Ld2 to the edge to the ridgeline L2, the entire surface becomes a gently raised surface.
Further, if necessary, chamfering may be performed near the intersection between the dividing line Ld and the ridge line L1, and near the intersection between the dividing line Ld and the ridge line L2.

Further, the positions R5 and R6 near the edge e1 where the dividing line Ld intersects the edge E of the tablet, and the positions R7 and R8 near the other edge e2 where the dividing line Ld intersects the edge E of the tablet are convex surfaces, respectively. The shape is chamfered.
The chamfered shape may be a flat surface.

The ridge line L1 is an intersection A1 of a line Ld2 that is a starting point of the dividing line Ld and a region R5 that is chamfered, a line Ld2 that is a starting point of the dividing line Ld, and a chamfered shape Is continued up to the intersection A2 with the region R7, and gradually rises from each of the intersection A1 and the intersection A2 in the vertical direction (Y-axis direction) of the tablet Ta, and perpendicular to the secant Ld from the center point C of the tablet Ta At the intersection A3 with the line L3, the highest position H4 in the vertical direction (Y-axis direction).
Similarly to the ridge line L1, the ridge line L2 is also an intersection A1 of the line Ld2 that is the starting point of the dividing line Ld and the region R6 that is chamfered, and a line Ld2 that is the starting point of the dividing line Ld, It continues to the intersection A2 with the region R8 that is chamfered, and gradually rises from each of the intersection A1 and the intersection A2 in the vertical direction (Y-axis direction) of the tablet Ta, and the center point of the tablet Ta At the intersection A3 with the line L3 perpendicular to the dividing line Ld from C, it is the highest position H4 in the vertical direction (Y-axis direction).

Further, the tablet Ta has a shape that gradually rises from the edge E to the center C of the tablet Ta, that is, a convex shape on the lower surface Sb (see FIG. 1 (c)).
Now, the distance in the horizontal direction (X-axis direction shown in FIG. The distance in the horizontal direction (X-axis direction shown in FIG. 1 (c)) from the center point C of the tablet Ta to the intersection A4 of the edge L and the line L3 that passes through the center point C and is perpendicular to the secant line Ld. When X2, the ratio of the distance X1 to the distance X2 ((X1 / X2) × 100) is preferably in the range of 60% to 80%, more preferably in the range of 70% to 80%. It is particularly preferable that it is 75%.

Further, the vertical distance from the center point C of the tablet Ta to the upper surface Sa of the edge E of the tablet Ta is Y1, and from the upper surface Sa of the edge E of the tablet Ta to the secant Ld through the center point C If the vertical distance to the intersection A3 between the perpendicular line L3 and the ridge line L1 is Y2, the ratio of the distance Y1 to the distance Y2 ((Y1 / Y2) × 100) is in the range of 20% to 50%. More preferably, it is in the range of 20% or more and 30% or less, and particularly preferably 23% or more and 25% or less.
Further, the shape formed on the lower surface Sb of the tablet Ta and gradually rising from the edge E of the tablet Ta toward the center C, that is, the curvature of the convex curve is a curve radius (the curve shown in FIG. 1 (c)). The ratio (Ds / D) of the radius Ds) to the diameter of the tablet Ta (the diameter D of the tablet Ta shown in FIG. 1B) is preferably in the range of 1.25 to 2.5.
In addition, the diameter D of the tablet Ta is preferably 5 mm or more and 14 mm or less, more preferably 7 mm or more and 10 mm or less in consideration of patient compliance and ease of division when taking without division. Is preferred.
When the divided tablet Ta is divided into two, a pharmacist, a patient, or the like can directly hold the two regions R1 and R2 with fingers and divide along the dividing line Ld.
Furthermore, there is an advantage that the tablet Ta can be divided into two if it is pushed downward from above.

FIG. 2 is a side view schematically showing a phenomenon that occurs in the divided tablet Ta when the divided tablet Ta is divided by applying a force in the vertical direction from the upper side to the lower side. FIG. Fig. 2 (b) shows a state immediately before applying force in the vertical direction from above to below, and Fig. 2 (b) shows a state immediately after applying force in the vertical direction from above to the divided tablet Ta. .
In the divided tablet Ta, each of the ridge line peripheral areas RL1 and RL2 of the ridge line L1 and L2 of the upper surface Sa of the tablet Ta is configured with a convex curved surface (see FIG. 2 (a)), and is seen in the tablet Tg and tablet Th Since the sharp edges Pe of the upper surface Sa of the tablets Tg and Th are eliminated, each of the ridge line peripheral regions RL1 and RL2 is not crushed or chipped. Thereby, if the tablet Ta is pushed downward from above, the tablet Ta can be neatly divided into two.

Further, since the divided tablet Ta eliminates the sharp edge portion Pe as seen in the tablet Tg and the tablet Th from the upper surface Sa of the tablet Ta, capping is unlikely to occur in the tableting process. (See Figure 2 (b)).
In addition, since the sharp edge portion Pe is eliminated from the upper surface Sa of the tablet Ta, even if the tablets Ta, ..., Ta collide with each other in the coating process, core erosion, edge chipping, etc. It is hard to produce.
In addition, even if the tablets Ta,..., Ta are pneumatically transported from one place to another, the tablets Ta,..., Ta collide with each other, or the tablets Ta,. -Even if Ta collides with the transport pipe, the tablet Ta does not have a sharp edge portion Pe, so that the tablet Ta is not easily chipped.
In addition, since the divided tablet Ta has two convex surfaces R1 and R2 on the upper surface and a convex surface R6 on the lower surface, the tablets do not make surface contact but make point contact. Thus, twinning is unlikely to occur in the coating process.
Furthermore, in this tablet Ta, the secant Ld is formed into a V-groove shape.

When the dividing line Ld is a V-groove, each of the two inclined surfaces SLd and SLd forming the V-groove that connects the deepest portion Ld1 and each of the lines Ld2 and Ld2 that are the starting ends becomes a plane.
On the other hand, in this tablet Ta, the shape of each of the two regions R1 and R2 from the lines Ld2 and Ld2 that are the starting ends of the dividing line Ld to each of the ridgelines L1 and L2 is a convex shape, and a V-groove is formed. The two inclined surfaces SLd and SLd have different shapes.
As a result, since the dividing line Ld is a V-groove, each of the lines Ld2 and Ld2 that are the starting ends of the dividing line Ld from the deepest portion Ld1 of the dividing line Ld in the horizontal direction (X-axis direction shown in FIG. 1 (c)) The increase rate of the thickness of the tablet Ta (the thickness in the vertical direction (Y-axis direction shown in FIG. 1 (c))) is uniform and gradually increases gradually.

On the other hand, since the surface from each of the lines Ld2 and Ld2 serving as the starting point of the dividing line Ld to each of the two regions R1 and R2 from the ridgelines L1 and L2 is a convex shape, From each of the lines Ld2 and Ld2 in the respective directions of the ridgelines L1 and L2, in the vicinity of each of the starting lines Ld2 and Ld2, with respect to the horizontal direction (X-axis direction shown in FIG.1 (c)), The thickness of the tablet Ta from the deepest part Ld1 of the dividing line Ld to each of the lines Ld2 and Ld2 which are the starting ends of the dividing line Ld (the thickness in the vertical direction (Y-axis direction shown in FIG. 1 (c))) is abrupt. It becomes thicker.
Thus, in this tablet Ta, in the region of the dividing line Ld, the change in thickness in the vertical direction with respect to the horizontal direction of the tablet Ta, and the ridgeline L1, from each of the lines Ld2 and Ld2 serving as the starting ends of the dividing line Ld, In each of the directions of L2, the starting lines Ld2 and Ld2 are changed in thickness in the vertical direction with respect to the horizontal direction of the tablet Ta in the vicinity of each of the lines Ld2, and the starting line of the dividing line Ld. The thickness in the vertical direction with respect to the horizontal direction of the tablet Ta at the position near each of the starting lines Ld2 and Ld2 in the direction of each of the ridgelines L1 and L2 from each of Ld2 and Ld2 is suddenly increased. The force acting from the outside of the tablet Ta per unit volume is large in the region of the dividing line Ld, and the starting ends in the directions of the ridgelines L1 and L2 from the lines Ld2 and Ld2 that are the starting ends of the dividing line Ld. Force acting from the outside of the tablet Ta per unit volume in the region of the secant line Ld at the position near each of the lines Ld2 and Ld2 Compared, therefore designed to be smaller, the tablet Ta, when divided into two, cleanly divided according dividing line Ld.

Furthermore, in this tablet Ta, the deepest part Ld1 of the dividing line Ld is positioned so that the position H1 of the deepest part Ld1 is located below the position H3 on the upper surface of the edge E of the tablet Ta, and the dividing line Ld is Since it is formed deeper than the dividing line of the divided tablet, it can be divided neatly along the dividing line Ld.
Further, when this tablet Ta is packaged in a press-through pack, the tablet Ta can be removed from the press-through pack 1 even when the tablet Ta is stored in the storage recess 2a of the storage body 2 of the press-through pack 1 without restricting the direction. There is an advantage that it can be divided into two before taking out Ta.
This will be described in more detail with reference to FIG.

FIG. 3 shows how the divided tablet Ta stored in the storage recess 2b of the storage body 2 of the press-through pack 1 is divided by applying a force in the vertical direction from the top to the bottom before taking out from the storage recess 2b. FIG. 3 is a side view schematically showing a phenomenon occurring in the divided tablet Ta, and FIG. 3 (a) shows a state immediately before applying force in the vertical direction from the upper side to the divided tablet Ta, and FIG. These respectively show the states immediately after applying force in the vertical direction from the top to the bottom of the divided tablets Ta.
In this divided tablet Ta, the lower surface Sb of the tablet Ta is provided with a shape that gradually rises from the edge E to the center C of the tablet Ta. In the case where the upper surface Sa on the side where the secant Ld is provided faces the sealing sheet 3 (see the tablet Ta housed in the left housing recess 2b in FIG. 3 (a)). When the convex portion 2c that is outside the storage recess 2b of the storage body 2 of the press-through pack 1 is pressed with a finger, the tablet is pressed by pressing the convex central portion A5 of the lower surface Sb of the tablet Ta with the finger. Ta can be easily divided into two (see tablet Ta housed in the left housing recess 2b in FIG. 3 (b)).
In addition, since the shape of the surface from each of the lines Ld2 and Ld2 serving as the starting ends of the dividing line Ld to each of the two ridgelines L1 and L2 is formed by a convex curved surface, the storage recess 2b of the press-through pack 1 When the side where the dividing line Ld of the tablet Ta is provided is stored so as to face the storage body 2 (see the tablet Ta stored in the storage recess 2b on the right side in FIG. 3 (a)). However, when the convex portion 2c that is outside the storage recess 2b of the press-through pack 1 is pressed with a finger, the tablet is compared with the storage recess 2b or finger shape that is generally crushed into a V shape when viewed from the side. Since each of the two regions R1 and R2 formed by the dividing line Ld of the upper surface Sa of Ta has a convex curved surface facing each other, the force by the finger is easily transmitted to the tablet Ta. As a result, force is applied to the tablet Ta in the direction to open the dividing line Ld without applying force to the finger. As a result, the side where the dividing line Ld of the tablet Ta is provided is stored in the storage recess 2b of the press-through pack 1. Even when stored so as to face the main body 2, the tablet Ta can be easily divided into two (the tablet Ta stored in the right storage recess 2b in FIG. reference).

3 includes a storage body 2 and a sealing sheet 5, and the adhesive layer 4 of the sealing sheet 3 is bonded to the plate-like portions 2a,..., 2a of the storage body 2. It has a structure.
The storage body 2 is usually thermoformed according to the shape of the divided tablets Ta,..., Ta to be stored, and the plurality of storage recesses 2b,. · · · 2a connected shape.

  As the material of the storage body 2, a commonly used thermoplastic synthetic resin such as polyvinyl chloride, polypropylene, polystyrene, and cyclic polyolefin can be used. If such a storage body material is used, a plurality of storage recesses can be used. The locations 2b,..., 2b can be easily formed by thermoforming according to the shape of the divided tablets Ta,.

Further, the sealing sheet 3 includes a base material 5 and an adhesive layer 4 provided on the surface on one side of the base material 5.
As the material of the base material 5 of the sealing sheet 3, the divided tablets Ta,..., Ta accommodated in the storage recesses 2b,. If the convex portions 2c,..., 2c, which are the outer surfaces of the two storage recesses 2b,. In general, various materials used as a packaging material can be used as long as the material is easily broken by each of the divided tablets Ta,... Examples of preferable examples thereof include aluminum foil, glassine paper, a synthetic resin sheet containing a filler for facilitating breakage, paper, and the like.

Specifically, when an aluminum foil is used as the base material 5 of the sealing sheet 3, it is preferable to use a hard foil having a thickness of 5 μm to 30 μm, more preferably 15 μm to 25 μm.
Further, when glassine paper is used as the base material 5 of the sealing sheet 3, one having a basis weight (weight per square meter) of 30.5 g / m ² is preferably used.
Further, when using a synthetic resin sheet containing a filler to facilitate breakage as the base material 5 of the sealing sheet 3, the thickness is preferably 9 μm to 100 μm, more preferably 12 μm to 80 μm. The following are used.
As this synthetic resin, thermoplastic synthetic resins such as polyvinyl chloride, polypropylene, polystyrene, and linear polyolefin are preferably used.

Further, as the filler to be included in the synthetic resin, for example, various materials such as silicon oxide, magnesium silicate, titanium dioxide, zinc white, calcium carbonate, alumina, talc can be used, and the average particle size is 1 μm or more and 10 μm or less. 5 wt% or more and 15 wt% or less, preferably 5 wt% or more and 70 wt% or less are mixed in the synthetic resin.
Further, when paper is used as the base material 5 of the sealing sheet 3, it is preferable to use a paper having a basis weight of 13 g / m ² or more and 100 g / m ² or less.

The physical properties and composition of the base material 5 of the sealing sheet 3 as described above are mainly the convex portion 2c of the storage main body 2, which is the outer surface of the storage recess 2b storing the divided tablets T, in the direction of the sealing sheet 5. When pressed with a finger, the portions r1,..., R1 sealing the storage recesses 2b,..., 2b of the sealing sheet 5 sealing the storage recess 2b are broken, and divided tablets Tough enough to extract T.
The above configuration is the same as that of the conventional press-through pack 101, but in this press-through pack 1, the adhesive layer 4 of the sealing sheet 3 and the plate-like portion 2a of the storage body 2 are bonded to each other. The strength of each of the convex portions 2c,..., 2c, which is the outer surface of each of the storage recesses 2b,. When pushed in three directions with a finger, the sealing recess 3 does not spread to the adhesive part r2, ..., r2 side between the plate-like part 2a and the adhesive layer 4, but the storage recess 2b, ...・ Only the portion (so-called pocket portion) r1..., R1 of the sealing sheet 3 sealing 2b is broken, and each of the divided tablets Ta,. When the sealing sheet 3 is peeled and turned up, the sealing sheet 3 is adjusted so that it can be easily separated from the storage body 2 without breaking in the middle. It is characterized in that there.

Hereinafter, regarding the method for adjusting the adhesive strength of the sealing sheet 3, the adhesive strength constituting the adhesive layer 4 is adjusted by the components of the adhesive, and the adhesive strength of the adhesive is applied to the base material 5 of the sealing sheet 3. The case will be described separately when the adjustment is made according to the construction method.
A. When the adhesive strength is adjusted by the components of the adhesive.
When the adhesive strength is adjusted according to the components constituting the adhesive, an appropriate amount of an adhesion reducing component is added to the adhesive component.

Specifically, the adhesive component may be any component as long as it can adhere the storage body 2 and the base material 5 of the sealing sheet 3. For example, even if it is a thermoplastic resin that can be heat sealed, a cold seal It may be a possible cold seal adhesive.
The thermoplastic resin that can be heat-sealed is not limited to the following. For example, when the storage body 2 is made of polyvinyl chloride, a vinyl chloride / vinyl acetate copolymer is used. As a preferable example thereof, for example, when the storage body 2 is made of polypropylene, chlorinated polypropylene and carboxylated polypropylene can be mentioned as preferable examples. For example, when the storage body 2 is made of polystyrene, a mixture of a vinyl chloride / vinyl acetate copolymer and an acrylic resin can be given as a preferred example.

Examples of the cold seal adhesive include acrylic resin, silicon resin, and rubber.
Here, the “cold seal adhesive” refers to an adhesive that can be bonded by simply pressurizing the member and the member when the members are bonded to each other.
Further, the adhesive strength-reducing component to be blended in the adhesive is the adhesive strength between the adhesive layer 4 of the sealing sheet 3 and the storage body 2, or the adhesive layer 4 of the sealing sheet 3 and the base material 5 of the sealing sheet 3. Any substance that lowers the adhesive strength can be used.
As such a substance, for example, a resin used as a release agent such as a silicone resin or a fluororesin, an acrylic resin, a linear polyester resin, or the like can be given as preferred examples.
Moreover, the fine powder used as fillers, such as a silicon oxide, magnesium silicate, titanium dioxide, zinc white, calcium carbonate, an alumina, a talc, can also be mentioned as the preferable example.
The blending ratio of the adhesive component and the adhesive strength reducing component of the adhesive is determined by an adhesive strength test, an extrusion test, and a peel test, which will be described later.

B. When the adhesive strength is adjusted by the method of applying the adhesive to the base material of the sealing sheet.
In this case, the adhesive is applied to the base material 5 of the sealing sheet 3 over the entire surface or partially, and the unit area of the adhesive applied to the base material 5 of the sealing sheet 3 The desired adhesive strength can be obtained by adjusting the amount of coating per unit.
In addition, partial coating, for example, storage of the sealing sheet 3 as long as each of the divided tablets Ta, ..., Ta stored in each of the storage recesses 2b of the storage body 2 can be completely sealed The adhesive may be applied to the surface on the side facing the main body 2 in a knitted or linear shape, or at least two of these may be applied in combination.
Further, in order to adjust the coating amount per unit area of the adhesive applied to the base material 5 of the sealing sheet 3, an adhesive appropriately mixed with a diluent or the base material of the sealing sheet 3 can be used. The film thickness per unit area of the adhesive applied to 5 may be adjusted.
Further, when the adhesive strength is adjusted by the method of applying the adhesive to the base material 5 of the sealing sheet 3, the adhesive may or may not contain an adhesive strength-reducing component. I will note that.

In this press-through pack 1, each of the divided tablets Ta,..., Ta is accommodated in each of the storage recesses 2b,.
Therefore, if each of the convex portions 2c,..., 2c that are the outer surfaces of the storage recesses 2b,..., 2c is crushed with fingers, the divided tablets Ta,. It can be taken out individually from each of the recesses 2b, ..., 2b.
In addition, the pharmacist or patient takes out the necessary number of divided tablets Ta,..., Ta individually from each of the storage recesses 2b,. For example, the tablets Ta can be individually grasped and divided into two along the dividing line Ld.

  Further, in this press-through pack 1, each of the storage recesses 2b,..., 2b accommodates divided tablets Ta,. Since the sealing sheet 3 side is in contact with a flat surface such as a table, each of the convex portions 2c,..., 2c serving as the outer surfaces of the storage recesses 2b,. , 2b before taking out each of the divided tablets Ta,..., Ta from each of the storage recesses 2b,..., 2b. Each of the divided tablets Ta,..., Ta can be divided into two in a state where each of Ta,.

Therefore, among the divided tablets Ta,..., Ta, after dividing the required number of divided tablets Ta,..., Ta into two while being accommodated in the storage recesses 2b,. Each of the convex portions 2c,..., 2c serving as the outer surface of the storage recesses 2b,..., 2b in which the divided tablets Ta,. When squeezed, each of the divided tablets Ta,..., Ta divided into two individually from each of the storage recesses 2b,.
Further, in this press-through pack 1, when the sealing sheet 3 is peeled and turned up, the sealing sheet 3 can be easily separated from the storage body 2 without breaking in the middle. If the sheet 3 is peeled and turned up, all the divided tablets Ta,..., Ta accommodated in the press-through pack 1 can be taken out from the press-through pack 1 at a time.
Not only this press-through pack 1 contains divided tablets Ta,..., Ta that are not restricted in direction when divided into two, as shown in FIG. First, with the sealing sheet 3 side in contact with a flat surface such as a table, each of the convex portions 2c,..., 2c serving as the outer surface of the storage recesses 2b,. , And squeeze all the divided tablets Ta, ..., Ta into two before taking out each of the divided tablets Ta, ..., Ta from each of the storage recesses 2b, ..., 2b. (Fig. 4 (a) ~ Fig. 4 (c)), then, if the sealing sheet 3 is peeled off from the storage body 2, it is accommodated in the press-through pack 1, divided into two parts. All the divided tablets Ta,..., Ta can be taken out from the press-through pack 1 at a time.

Thereby, if this press-through pack 1 is adopted, the divided tablets Ta,..., Ta can be divided into two before taking out from the storage recesses 2b,. Therefore, when the tablet Ta is divided into two parts by fingers, etc., the tablet Ta will not be contaminated by bacteria, molds, etc. adhering to the fingers, etc. When the sealing sheet 3 is peeled off from the storage body 2 and turned up, all the divided tablets Ta,..., Ta contained in the press-through pack 1 are transferred from the press-through pack 1 at a time. Can be taken out.
Furthermore, if this press-through pack 1 is used, if it is necessary to prepare a large amount of tablets Ta divided into two, Ta, storage recesses 2b, ..., 2b Before taking out each of the divided tablets Ta, ..., Ta, divide all the divided tablets Ta, ..., Ta into two, and then peel off the sealing sheet 3 from the storage body 2 If it raises, since it can be taken out from the press-through pack 1 at once, all the divided tablets Ta, ..., Ta, which are contained in the press-through pack 1, are divided into two, the hospital Can greatly improve the dispensing business.
The above-described divided tablet Ta is merely illustrated as a preferred example for the purpose of explaining the present invention. The present invention is not limited to the divided tablet Ta.

FIGS. 5 to 7 are views exemplarily showing modifications of the present invention. FIG. 5 is a diagram schematically showing another example of the divided tablet according to the present invention, in which FIG. 5 (a) is a plan view, FIG. 5 (b) is a bottom view, and FIG. Shows side views, respectively.
This divided tablet Tb is different from the divided tablet Ta in that the dividing line Ld is formed larger than the divided tablet Ta.
That is, this divided tablet Tb has a width (width w2 shown in FIG. 5 (a)) between the two starting lines Ld2 and Ld2 forming the dividing line Ld as compared with the divided tablet Ta. It is formed larger than the width (width w1 shown in FIG. 1 (a)) between the two starting lines Ld2 and Ld2 forming the Ta dividing line Ld (w2> w1). The divided tablet Tb has two vertical lines Ld2 and Ld2 forming the dividing line Ld and a vertical distance (distance Y8 shown in FIG. 5 (c)) from the deepest portion Ld1 of the divided tablet Ta. It is formed to be longer than the vertical distance (distance Y7 shown in FIG. 1 (c)) from the two starting lines Ld2 and Ld2 forming the dividing line Ld to the deepest portion Ld1 (Y8> Y7). ).

Thereby, since the size of the dividing line Ld is larger than that of the divided tablet Ta, the divided tablet Tb can be easily divided into two with a smaller force than the divided tablet Ta.
Not only in this divided tablet Tb, when the size of the dividing line Ld is increased, the distance in the vertical direction from the position H3 of the upper surface Sa of the edge E of the tablet Tb to the lines Ld2 and Ld2 that are the starting ends of the dividing line Ld (Distance Y10 shown in FIG. 5 (c)) is a vertical distance from the position H3 of the upper surface Sa of the edge E of the tablet Ta to the lines Ld2 and Ld2 that are the starting ends of the dividing line Ld (in FIG. 5 (c)). The distance in the vertical direction from the deepest part Ld1 of the dividing line Ld to the bottom vertex A5 of the tablet Tb (the distance Y6 shown in FIG. 5 (c)) Since the distance in the vertical direction from the deepest part Ld1 of the dividing line Ld to the bottom vertex A5 of the tablet Ta (distance Y3 shown in FIG. 1 (c)) (Y6 = Y3), The mechanical strength at the position of the portion Ld1 is substantially the same as the mechanical strength at the position of the deepest portion Ld1 of the dividing line Ld of the tablet Ta.

Thus, when the divided tablet Tb is divided into two, which are considered to be technically contradictory, since the size of the dividing line Ld is large, it can be divided into two with a small force.
Since the other shapes of the divided tablets Tb are the same as those of the divided tablets Ta, the corresponding portions are denoted by the corresponding reference numerals and the description thereof is omitted.

FIG. 6 is a diagram schematically showing another example of the divided tablet according to the present invention, in which FIG. 6 (a) is a plan view, FIG. 6 (b) is a bottom view, and FIG. Shows side views, respectively.
This divided tablet Tc is different from the divided tablet Ta in which the dividing line Ld is a V-groove in that the dividing line Ld is a U-groove.
In this divided tablet Tc, since the dividing line Ld is a U-groove, the thickness of the tablet Tc is within the region of the dividing line Ld from the deepest portion Ld1 of the dividing line Ld to the lines Ld2 and Ld2 that are the starting ends of the dividing line Ld. Until the dividing line Ld becomes the starting point, and becomes thick in the vicinity of each of the lines Ld2 and Ld2.

On the other hand, in this divided tablet Tc, the surface from each of the lines Ld2 and Ld2 serving as the starting ends of the dividing line Ld to each of the two regions R1 and R2 is a convex shape. The thickness of the tablet Tc suddenly increases at the position near each of the starting lines Ld2 and Ld2 in the direction of each of the ridgelines L1 and L2 from each of the lines Ld2 and Ld2 that are the starting edges of the dividing line Ld. .
Thus, in this tablet Tc, the change in the thickness of the tablet Tc in the region of the dividing line Ld, and the direction of each of the ridgelines L1, L2 from each of the lines Ld2, Ld2 serving as the starting ends of the dividing line Tc, The change in thickness of the tablet Tc in the vicinity of each of the starting lines Ld2 and Ld2 is remarkably different from each of the ridgelines L1 and L2 from each of the lines Ld2 and Ld2 that are the starting lines of the dividing line Ld. The thickness of the tablet Tc in the vicinity of each of the starting lines Ld2 and Ld2 in the direction of is increased rapidly, and the force acting from the outside of the tablet Tc per unit volume is the area of the secant Ld. Within the region of the dividing line Ld at a position near each of the starting lines Ld2 and Ld2 in the direction of each of the ridgelines L1 and L2 from each of the lines Ld2 and Ld2 that are large and within the dividing line Ld2 Since the force acting from the outside of the tablet Tc per unit volume of the tablet Tc is made smaller, when the tablet Tc is divided into two, it follows the secant Ld. It can be divided into marriageable age.
Since the other shapes of the divided tablets Tc are the same as those of the divided tablets Ta, the corresponding portions are denoted by the corresponding reference numerals and the description thereof is omitted.

FIG. 7 is a diagram schematically showing another example of the divided tablet according to the present invention, in which FIG. 7 (a) is a plan view, FIG. 7 (b) is a bottom view, and FIG. Shows side views, respectively.
This divided tablet Td has an elliptical shape when viewed in plan (see FIG. 7 (a)), and the tablet shape is circular when viewed in plan. It is different from the divided tablet Ta (see FIG. 1 (a)).
In this divided tablet Td, a secant Ld is formed along the short axis L4.
When the tablet is viewed in plan or elliptical, the curvature of the bottom curve L6 is the curve radius (curve radius Ds shown in FIG. 7 (c)) is the major axis of the tablet Td (long The ratio (Ds / Do) to the length of the axis L5 (the long diameter Do of the tablet Td shown in FIG. 7B) is preferably in the range of 1.25 to 2.5.

This divided tablet Td also has the same effect as the divided tablet Ta. Furthermore, in the divided tablet Td, the tablet shape is elliptical when viewed in plan, and the dividing line Ld is provided along the short axis L4. Therefore, the dividing line of the two regions R1 and R2 formed by the dividing line Ld The distance from Ld to each of the intersections A4 and A4 where the edge E of the tablet Td and the long axis L5 intersect becomes a dimension Do / 2 that is a half of the major axis, and becomes longer. As a result, it is possible to increase the moment when the finger is split into two, so that the finger can be split into two even if little force is applied to the finger.
In this example, the example in which the dividing line Ld is provided along the short axis L4 has been described, but it goes without saying that the dividing line Ld may be provided along the long axis L5.
Since the other shapes of the divided tablets Td have the same relationship as the divided tablets Ta, the corresponding portions are denoted by the corresponding reference numerals and the description thereof is omitted.

  Further, in the divided tablets Ta, Tb, Tc, Td shown above, the convex shape is formed in the vicinity of the intersections e1, e2 where the edge E of the divided tablets Ta, Tb, Tc, Td and the dividing line Ld intersect. The regions having chamfered regions R5, R6, R7, R8 have been described, but the regions R5, R6, R7, R8 chamfered into a convex shape are not necessarily required surfaces, but divided tablets Ta, Tb, Tc, When the regions R5, R6, R7, and R8 chamfered to have a convex shape such as Td are provided, chipping is further less likely to occur when the divided tablets Ta, Tb, Tc, and Td are manufactured or transported. (Note that this has been found by the inventors through experiments in Experimental Examples 1 and 2 shown below.)

Further, in the divided tablets Ta, Tb, Tc, and Td shown above, the case where the V-groove or the U-groove is provided as the dividing line Ld has been described. It may be the V groove shape shown in (a) or the U groove shape shown in FIG. 8 (d), but as shown in FIG. Even if it is a shape having R11 or a parabola (quadratic curve) shape, the rounded portion R11 is not a smooth curve near the long angle of the v-groove as shown in FIG. It may have a polygonal shape having one or more Lb (see region R12 shown in FIG. 8 (c)), and round round at the bottom like a normal U groove as shown in FIG. 8 (e). Instead of making the part a smooth curve (see region R13 shown in FIG. 8 (d)), it may be a polygonal shape having one or more bent portions Lb (see region R14 shown in FIG. 8 (e)). .
If the dividing line Ld is made into a polygonal shape having one or more bent portions Lb, when the divided tablet is divided into two, the force concentrates on any of the bent portions Lb, so along any of the bent portions Lb. Since it is easy to be divided into two, it becomes possible to further divide it neatly along the dividing line Ld.

Further, in the divided tablets Ta, Tb, Tc, Td, all the edges of the tablets Ta, Tb, Tc, Td from each of the ridgelines L1, L2 of the upper surface Sa of each of the tablets Ta, Tb, Tc, Td The case where the shape of the steep slopes R3, R4 up to E is a convex curve when viewed in cross section has been described, but the shape of the steep slopes R3, R4 as a planar shape when viewed in cross section Good.
In this case, convex surfaces (gradual uplift curves) shaped surfaces R1 and R2 from the lines Ld2 and Ld2 that are the starting ends of the dividing line Ld on the upper surface of the tablets Ta, Tb, Tc, and Td to the ridgelines L1 and L2, respectively. When the cross section is viewed, the joint portion with the steep slopes R3 and R4 having a planar shape is not joined at the ridge lines L1 and L2, but from the ridge lines L1 and L2 so as not to cause chipping of the tablet. It is preferable to provide at a position where the height in the vertical direction is lower than the ridgelines L1 and L2 at positions close to the edge E of each of the tablets Ta, Tb, Tc and Td.

In the divided tablet according to the present invention, whether the shape of the steep slope from the ridge line on the upper surface of the tablet to the edge of the tablet is a straight or convex curve can be determined from the design surface of the tablet. .
Therefore, the divided tablet according to the present invention can be produced in a tablet shape so that the shape of the tablet can be impressed by a doctor, a pharmacist, a patient, or the like based on its medicinal effect, efficacy, effect, etc. it can.

More specifically, for example, when the shape from the starting line of the dividing line on the upper surface of the tablet to the ridgeline is viewed in cross-section, the appearance of the entire tablet of the viewer is sharpened by making it a straight line. Therefore, if the product is characterized by a sharp sharpness, such as an oral antibiotic preparation or an analgesic / anti-inflammatory agent, the sharpness of these drugs can be impressed by the viewer.
In addition, when the shape from the starting line of the dividing line on the upper surface of the tablet to the ridgeline is viewed in cross-section, the gentle impression of the entire tablet of the viewer will be mild if it is a gentle bulge curve. The product features mild effect and few side effects. For example, if the form of cardiovascular agents such as antihypertensive drugs and central nervous system agonists such as sleeping / sedating drugs is used, the viewer will be impressed with the mildness of the effects of these drugs and the few side effects. be able to.
Next, the present invention will be described based on specific experimental data.

Lactose (DMV: 200M) 67.5% by weight and corn starch (Nihon Shokuhin Co., Ltd .: Solar corn starch W) 29.0% by weight are charged into a fluid bed granulator (Freund Corporation: Flow coater FLO-15). Then, hydroxypropylcellulose (manufactured by Nippon Soda Co., Ltd .: HPC-L) was adjusted to a 7% by weight aqueous solution as a binder to these powders, and this was sprayed to granulate and dry to obtain a dry powder. The dry powder contained 3% by weight of a binder.
Next, the dried powder produced as described above is sized with a particle sizer (manufactured by Tokuju Factory: Landel Mill RM-I), and a lubricant (magnesium stearate (manufactured by Sakai Chemical Co., Ltd.)) is applied to the obtained rectified product. 0.5% by weight was added and mixed for 5 minutes with a blender (manufactured by Deoksugaku Kosakusho: Mixwell Mixer V1-60) to obtain a molding material.
Next, in order to produce the divided tablets according to the present invention, the upper eyelid pa1, the upper eyelid pa2, and the upper eyelid pa3 shown in FIG. 9, and the lower eyelid pb1 and the lower eyelid pb2 shown in FIG. 10 were prepared.

Note that the upper punch pa1 and the upper punch pa2 are divided tablets that do not form chamfered regions (regions R5, R6, R7, R8 shown in FIG. 1) in the vicinity of the intersection of the dividing line Ld and the edge of the tablet. The upper ridge to be produced, and the upper ridge pa3 is a divided tablet in which chamfered regions (regions R5, R6, R7, R8 shown in FIG. 1) are formed in the vicinity of the intersection of the secant Ld and the edge of the tablet. This is the upper arm.
Each of the upper punches pa1, pa2, pa3 has a female mold in the shape of the upper surface of the divided tablet to be molded, and each of the lower punches pb1, pb2 has a female mold in the shape of the lower surface of the divided tablet to be molded Yes.

Further, in each drawing of FIG. 9 and FIG. 10, for reference, the parts corresponding to the shape of the divided tablet are shown in each of the upper punch pa1, pa2, pa3 and the lower punch pb1, pb2. Reference numerals corresponding to the portions of the shape are attached, and the dimensions of the produced upper collar pa1, pa2, pa3, and lower collar pb1, pb2 are entered.
Next, the upper punch pa1 and the lower punch pb1 were combined, and these were mounted on a high-speed rotary tableting machine (manufactured by Kikusui Seisakusho: VIRGO12), and the molding material produced as described above was tableted.
In addition, the combination of the upper punch pa1 and the lower punch pb2, the combination of the upper punch pa2 and the lower punch pb1, and the combination of the upper punch pa2 and the lower punch pb2, these are the high-speed rotary tablet press (manufactured by Kikusui Seisakusho: VIRGO12) was mounted, and the molding material prepared as described above was tableted.

Through the above steps, a total of four types of divided tablets according to the present invention were produced.
The weight per tablet was 130 mg in all cases.
Next, these four types of tablets are divided on a flat table by 5 randomly selected panelists (3 men: M, 2 women: W) with the dividing line facing up or down. The sensory test was conducted in four stages to determine the ease of division.
The evaluation was easy to break: 3 points, hard to break: 2 points, very hard to break: 1 point, not cracked: 0 points, with a maximum of 15 points.

In addition, as a comparative example, a commercially available lower-curved karate tablet (trade name Norpasque tablet: manufactured by Pfizer Pharmaceutical Co., Ltd.) was divided by the same method, and the ease of division at this time was 4 Sensory tests were performed in stages.
The results are shown in Table 1.

In Table 1, the dividing direction indicates whether the direction of the dividing line of the tablet is facing upward or facing downward.
According to Table 1, the four types of divided tablets according to the present invention, when compared with a comparative example (trade name Norpasque Tablets: Pfizer Pharmaceutical Co., Ltd.) and divided with the secant Ld facing upward, It became clear that it was easy to divide.
Further, it has been clarified that when the dividing line Ld is divided so as to face downward, it is easy to divide it equal to or more than the comparative example.

In order to further improve the four types of divided tablets according to the present invention, which were well divided in the sensory test of Experimental Example 1, the upper plate pa3 shown in FIG. 9 (c) and the lower plate shown in FIG. 10 (b) A split tablet according to the present invention was produced in the same manner as in Experimental Example 1 by combining 杵 pb2.
In addition, as a comparative example, a conventionally known lower-curved karate tablet combining the upper collar pa4 and the lower collar pb2 shown in FIG. 11 was produced in the same manner as in Experimental Example 1.
Next, a drop test was performed for each of the obtained divided tablets. In the drop test, 100 divided tablets according to the present invention and 100 comparative examples (lower-curved karate tablets) were dropped onto a stainless steel plate from the position of 40 cm in height, and the missing part and the number of tablets were visually observed. This was done by observing.
Note that the observation site of the missing part is shown in FIG. 12 (a), the three parts F1, F2, F3 on the upper surface Sa of the divided tablet, and the part of the lower surface Sb of the divided tablet shown in FIG. 12 (b). A total of 4 F4 locations were used.
The results of the drop test are shown in Table 2.

From Table 2, it was revealed that the divided tablets according to the present invention had a remarkably small number of total chips compared to the comparative example (lower-curved karate tablet).
In addition, when analyzing the type of chip, chipping (edge chipping) at the edge portion was particularly reduced.

A split tablet according to the present invention was produced in the same manner as in Experimental Example 1, using the upper eyelid pa3 shown in FIG. 9 (c) and the lower eyelid pb1 shown in FIG. 10 (a).
Further, a split tablet according to the present invention was produced in the same manner as in Experimental Example 1 using the upper eyelid pa3 shown in FIG. 9 (c) and the lower eyelid pb2 shown in FIG. 10 (b).
As a comparative example, a conventionally known lower-curved karate tablet was produced in the same manner as in Experimental Example 1 using the upper collar pa4 and the lower collar pb1 shown in FIG.
Further, as a comparative example, using the upper collar pa4 shown in FIG. 11 (a) and the lower collar pb1 shown in FIG. Was made.
Next, a friability test was performed on each of the obtained divided tablets.
The friability test was carried out by putting 20 split tablets according to the present invention and 20 comparative examples (lower-curved karate tablets) in a fly aviator and rotating them at 25 rpm for 10 minutes or 20 minutes. This was done by measuring the degree.
The results of the friability test are shown in Table 3.

  From Table 3, it was revealed that the divided tablets according to the present invention had about half the friability compared to the comparative example (lower-curved karate tablet).

A 1 kg divided tablet according to the present invention prepared in Experimental Example 3 is coated with a coating solution (OPADRY-II (Colorcon: OY-LS-22813) aqueous solution) using a coating machine (Freund: HCT-30N). did.
Further, in Experimental Example 3, 1 kg of a conventionally known lower-curved karate tablet produced as a comparative example was coated with a coating machine (OPADRY-II (Colorcon: OY-LS-22813) aqueous solution) coating machine (Freund Corporation). : HCT-30N).
As a result, the split tablet according to the present invention did not cause twinning, and no peeling of the coating film caused by the twinning was observed.

Here, when the divided tablets of the present invention were stored in a press-through pack, it was tested that tablets could be divided in large quantities.
The divided tablet (coated) according to the present invention produced in Experimental Example 4 was accommodated in the storage recess of the press-through pack.
Next, the divided tablet (coated) according to the present invention, which is accommodated in the storage recess of the press-through pack, and 10 tablets with the secant line stored upward, Each of the divided tablets (coated) and divided into two tablets by pressing and dividing them with 10 fingers without taking out from the storage recess, respectively, with 10 tablets stored with the dividing line facing downward Each of these was precisely weighed with an analytical balance, and when divided into two, the weight variation coefficient of the tablet generated in the divided tablet (coated) according to the present invention was determined.

As a comparative example, using a commercially available tablet cutter (manufactured by Kobayashi Pharmaceutical Co., Ltd.), it is a divided tablet according to the present invention (coated), 10 tablets with the secant line facing upward, and the present invention Each of these divided tablets (coated), 10 tablets with the score line facing upwards, is cut along the score line, and each of the two divided tablets is refined with an analytical balance. When weighed and divided into two, the weight variation coefficient of the tablet generated in the divided tablet (coated) according to the present invention was determined.
The results are shown in Table 4.

According to Table 4, the divided tablet according to the present invention was divided along the dividing line by the tablet cutter, the weight variation coefficient of the tablet after being divided into two, regardless of whether the dividing line is facing upward or downward. It is clear that the divided tablet according to the present invention can be divided into two accurately with a finger, regardless of whether the secant line is facing up or down, without much difference from the weight variation coefficient of the later tablet. Became.
Furthermore, this experiment shows that the coefficient of variation of the tablet produced using lower iron pb2 having a larger radius of curvature is lower than that of the tablet produced using lower iron pb1 compared to lower iron pb1. ,It was revealed. This is considered because the fracture area at the time of division | segmentation becomes small.

The divided tablet according to the present invention produced in Example 2 was stored in a press-through pack, and the hardness required for the division was measured in a state where the divided tablet was stored in a storage recess of the press-through pack. Measured with PTB-311 / P, manufactured by Machinery.
In addition, as a comparative example, a commercially available lower-curved Karate tablet (trade name Norpasque Tablets: manufactured by Pfizer Pharmaceutical Co., Ltd.) is used, and the hardness required for division in a state where the divided tablets are stored in the storage recess of the press-through pack. Was measured with a tablet hardness tester (PTB-311 / P, manufactured by Japan Machinery Co., Ltd.).
The press-through pack used in the comparative example is the same as the press-through pack used to store the divided tablet according to the present invention, and the packaging method of the comparative example is also the divided tablet according to the present invention. Was carried out in the same manner as that contained in the press-through pack.
The results are shown in Table 5.

From Table 5, it became clear that the divided tablet according to the present invention can be divided with about one-fourth the force of the comparative example.
From the above results, it became clear that the divided tablet according to the present invention has a shape that can be divided more easily than conventionally known divided tablets.

FIG. 1 schematically shows an example of a divided tablet according to the present invention, in which FIG. 1 (a) is a plan view, FIG. 1 (b) is a bottom view, and FIG. 1 (c) is FIG. The side views according to the line II shown in FIG. FIG. 2 (a) is a side view schematically showing a phenomenon that occurs in a divided tablet when the divided tablet according to the present invention is divided by applying a force in the vertical direction from above to below, and FIG. FIG. 2 (b) shows a state immediately before the force is applied in the vertical direction downward, and FIG. 2 (b) shows a state immediately after the force is applied in the vertical direction from above to the divided tablet. When the divided tablet according to the present invention stored in the storage recess of the storage body of the press-through pack is divided by applying a force in the vertical direction from the top to the bottom before taking out from the storage recess, the split tablet is generated. FIG. 3 (a) is a side view schematically showing the phenomenon, and FIG. 3 (a) shows a state immediately before force is applied in the vertical direction from above to the divided tablet, and FIG. The state immediately after applying a force in the vertical direction downward is shown. It is explanatory drawing which shows an example of the usage example of the press through pack which concerns on this invention typically. FIG. 5 is a view schematically showing another example of the divided tablet according to the present invention, FIG. 5 (a) is a plan view, FIG. 5 (b) is a bottom view, and FIG. 5 (c) is a side view. , Each showing. FIG. 6 schematically shows another example of the divided tablet according to the present invention, FIG. 6 (a) is a plan view, FIG. 6 (b) is a bottom view, and FIG. 6 (c) is a side view. , Each showing. FIG. 7 schematically shows another example of the divided tablet according to the present invention, FIG. 7 (a) is a plan view, FIG. 7 (b) is a bottom view, and FIG. 7 (c) is a side view. , Each showing. FIG. 9 is a schematic view schematically showing the shape of the dividing line provided in the divided tablet according to the present invention, and each of FIGS. 8 (a) to 8 (e) illustrates a preferable shape of such a dividing line. FIG. 9 is a diagram schematically showing the shape of the upper eyelid used for producing the divided tablet according to the present invention, and each of FIGS. 9 (a) to 9 (c) shows the upper eyelid used in the experiment. Yes. FIG. 10 is a diagram schematically showing the shape of the lower eyelid used for producing the divided tablet according to the present invention, and each of FIGS. 10 (a) and 10 (b) shows the lower eyelid used in the experiment. Yes. FIG. 11 is a diagram schematically showing the shapes of the upper and lower eyelids used for producing a conventionally known lower-curved karate tablet. FIG. 11 (a) shows the upper eyelid used in the experiment and FIG. (b) shows the lower arm used in the experiment. FIG. 12A is an explanatory diagram for explaining the observation location of the chipped portion of the tablet in the drop test, FIG. 12A is the observation location of the upper surface of the divided tablet, and FIG. 12B is the observation of the lower surface of the divided tablet. Each location is shown. FIG. 13 is a view schematically showing a conventional flat divided tablet, FIG. 13 (a) is a plan view, FIG. 13 (b) is a bottom view, and FIG. 13 (c) is a view in FIG. The side view according to the II line shown in each is shown. FIG. 14 is a diagram schematically showing a conventional karate-type divided tablet described in JP-A-61-289027 (Patent Document 1), FIG. 14 (a) is a plan view, and FIG. 14 (b) is a bottom view. FIG. 14 (c) shows a side view according to the line II shown in FIG. 14 (a). FIG. 15 is a diagram schematically showing an example of a divided tablet described in JP-A-8-53345 (Patent Document 2), in which FIG. 15 (a) is a plan view, FIG. 15 (b) is a bottom view, FIG. 15 (c) shows side views according to line II shown in FIG. 15 (a). FIG. 16 schematically shows another example of the divided tablet described in JP-A-8-53345 (Patent Document 2), FIG. 16 (a) is a plan view, FIG. 16 (b) is a bottom view, Further, FIG. 16 (c) shows side views according to the line II shown in FIG. 16 (a). It is sectional drawing which shows an example of the conventional press through pack typically. FIG. 18 (a) is a side view schematically showing a phenomenon that occurs in a divided tablet when a conventional divided tablet is divided by applying a force in the vertical direction from above to below, and FIG. FIG. 18 (b) shows a state immediately before the force is applied in the vertical direction, and FIG. 18 (b) shows a state immediately after the force is applied in the vertical direction from the upper side to the divided tablet Ta. FIG. 18 (a) schematically illustrates a problem that occurs when a conventional split tablet is divided into two while being stored in the storage recess in the storage recess of the storage body of the press-through pack. FIG. 18 (b) shows a state immediately before applying a force in the vertical direction from the top to the bottom of the tablet, and FIG. 18 (b) shows a state immediately after applying force in the vertical direction from the top to the bottom of the divided tablets. . FIG. 20 (a) is a side view schematically showing a phenomenon that occurs in a divided tablet when a conventional divided tablet is divided by applying a force in the vertical direction from above to below, and FIG. FIG. 20 (b) shows a state immediately before the force is applied in the vertical direction, and FIG. 20 (b) shows a state immediately after the force is applied in the vertical direction from the upper side to the divided tablet Ta. FIG. 21 (a) schematically illustrates a problem that occurs when a conventional divided tablet is divided into two while being stored in the storage recess in the storage recess of the storage body of the press-through pack. FIG. 21 (b) shows a state immediately before applying force in the vertical direction from the top to the bottom of the tablet, and FIG. 21 (b) shows a state immediately after applying force in the vertical direction from the top to the bottom of the divided tablets. .

Explanation of symbols

Ta, Tb, Tc, Td Split tablet Sa Upper face Sb of split tablet Lower face E of split tablet Edge L1, L2 Edge line RL1, RL2 Edge area around the edge line R5, R6, R7, R8 Shape of chamfered convex shape Region Ld secant line Ld1 deepest part of secant line (line formed at the deepest part of secant line)
Ld2 The line that is the starting point of the dividing line θ The vertex angle e1 of the dividing line V groove The other edge R1, R2 opposite to the edge e2 e1 The region 1 formed on the upper surface of the tablet by the dividing line 1 Press-through pack 2 Storage body 2a Plate Section
2b Storage recess 2c Convex 3 Sealing sheet 4 Adhesive layer 5 Base material

Claims (13)

A tablet having an upper surface and a lower surface and an edge of the tablet therebetween,
On the upper surface of the tablet, a ridge line is formed so as to surround the dividing line and to be located on the inner side of the edge of the tablet in each of a dividing line formed along a center line and two regions formed by the dividing line. And formed,
The lower surface of the tablet has a shape that gradually rises from the edge of the tablet toward the center,
The ridge line peripheral area of each of the two ridge lines is composed of a convex curved surface,
And the dividing tablet which comprises the said dividing line by the deepest part of a groove | channel and the dividing line which consists of two lines used as the starting point of a dividing line. A tablet having an upper surface and a lower surface and an edge of the tablet therebetween,
On the upper surface of the tablet, a ridge line is formed so as to surround the dividing line and to be located on the inner side of the edge of the tablet in each of a dividing line formed along a center line and two regions formed by the dividing line. And formed,
The lower surface of the tablet has a shape that gradually rises from the edge of the tablet toward the center,
The ridge line peripheral area of each of the two ridge lines is composed of a convex curved surface,
And the division | segmentation tablet by which the vicinity of the intersection of the said edge part of a tablet and a secant is chamfered by the convex shape formed so that each may pinch | interpose a secant. A tablet having an upper surface and a lower surface and an edge of the tablet therebetween,
On the upper surface of the tablet, a ridge line is formed so as to surround the dividing line and to be located on the inner side of the edge of the tablet in each of a dividing line formed along a center line and two regions formed by the dividing line. And formed,
The lower surface of the tablet has a shape that gradually rises from the edge of the tablet toward the center,
The ridge line peripheral area of each of the two ridge lines is composed of a convex curved surface,
In addition, the divided tablet in which a surface extending from the secant line to each of the two ridge lines is configured by a convex curved surface. 3. The divided tablet according to claim 2, wherein a surface from the secant line to each of the two ridge lines is formed by a convex curved surface. The divided tablet according to any one of claims 2 to 4, wherein the dividing line is composed of a deepest part of the groove and two lines serving as the starting ends of the dividing line. The dividing line is composed of a deepest part of the groove and two lines that are the starting ends of the dividing line, and the deepest part of the groove is formed below the upper surface of the edge of the tablet. The divided tablet according to any one of claims 2 to 4. 7. The divided tablet according to claim 1, 5 or 6, wherein each of the lines serving as the starting ends of the dividing line is formed at a position above the upper surface of the edge of the tablet. The divided tablet according to any one of claims 1 to 7, wherein the dividing line is formed so as to be located below the upper surface of the edge of the tablet. 9. The divided tablet according to claim 1, wherein the dividing line is a V groove or a U groove. The surface from each of the two ridge lines to the edge of the tablet is formed with a steeper slope than the surface from the secant line to the two ridge lines. 9. The divided tablet according to any one of 9 above. 11. The divided tablet according to claim 10, wherein a surface from each of the two ridge lines to an edge of the tablet is a straight or convex curve when viewed in cross section. A sealing body having a storage body having a plurality of storage recesses connected by a plate-like portion, a base material, and an adhesive layer provided on one surface of the base material,
The adhesive layer of the sealing sheet and the plate-like portion of the storage main body are bonded in a state where a tablet is stored in each of the plurality of storage recesses, and the storage main body is sealed by the sealing sheet. A press-through pack,
The tablet has an upper surface, a lower surface, and an edge of the tablet between them,
A dividing line formed along the center line on the upper surface of the tablet, and a ridge line so as to surround the dividing line and to be located inside the edge of the tablet in each of two regions formed by the dividing line Formed,
The lower surface of the tablet has a shape that gradually rises from the edge of the tablet toward the center,
And each ridge line peripheral area of the two ridge lines is composed of a convex curved surface,
The sealing sheet is
When the convex part which becomes the outside of the storage recess storing the divided tablet is pushed with a finger, the adhesive part between the adhesive layer of the sealing sheet and the plate-like part of the storage main body does not float or peel off. , By breaking the portion of the sealing sheet that seals the storage recess, the split tablet can be taken out, and
A press-through pack that is bonded to a plate-like portion of the storage body so that the storage body can be easily peeled off. A sealing body having a storage body having a plurality of storage recesses connected by a plate-like portion, a base material, and an adhesive layer provided on one surface of the base material,
In each of the plurality of storage recesses of the storage main body, the adhesive tablet layer of the sealing sheet and the plate-shaped portion of the storage main body in a state where the divided tablet according to any one of claims 1 to 11 is stored. Is adhered, the storage body is sealed by the sealing sheet,
The sealing sheet is
The adhesion between the adhesive layer of the sealing sheet and the plate-like portion of the storage body when the convex portion which is outside the storage recess storing the divided tablet according to any one of claims 1 to 11 is pressed with a finger. In the part, without causing floating or peeling, the portion of the sealing sheet sealing the storage recess can be broken, and the divided tablet according to any one of claims 1 to 11 can be taken out, and ,
A press-through pack adhered to a plate-like portion of the storage body so that the storage body can be easily peeled off.

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