JP2005525879A - Injection device with automatic retractable needle - Google Patents

Injection device with automatic retractable needle Download PDF

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JP2005525879A
JP2005525879A JP2004505128A JP2004505128A JP2005525879A JP 2005525879 A JP2005525879 A JP 2005525879A JP 2004505128 A JP2004505128 A JP 2004505128A JP 2004505128 A JP2004505128 A JP 2004505128A JP 2005525879 A JP2005525879 A JP 2005525879A
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capsule
injection device
needle
plunger
drive member
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マーシャル，ジェレミー
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オウエン マンフォード リミティド
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/20—Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically
    • A61M5/2033—Spring-loaded one-shot injectors with or without automatic needle insertion
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/32—Needles; Details of needles pertaining to their connection with syringe or hub; Accessories for bringing the needle into, or holding the needle on, the body; Devices for protection of needles
    • A61M5/3205—Apparatus for removing or disposing of used needles or syringes, e.g. containers; Means for protection against accidental injuries from used needles
    • A61M5/321—Means for protection against accidental injuries by used needles
    • A61M5/3243—Means for protection against accidental injuries by used needles being axially-extensible, e.g. protective sleeves coaxially slidable on the syringe barrel
    • A61M5/326—Fully automatic sleeve extension, i.e. in which triggering of the sleeve does not require a deliberate action by the user
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/20—Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically
    • A61M2005/206—With automatic needle insertion
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/20—Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically
    • A61M2005/2073—Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically preventing premature release, e.g. by making use of a safety lock
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/20—Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically
    • A61M2005/2086—Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically having piston damping means, e.g. axially or rotationally acting retarders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M2005/3143—Damping means for syringe components executing relative movements, e.g. retarders or attenuators slowing down or timing syringe mechanisms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/24—Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic

Abstract

注射装置が針を有しており、前記針は、注射装置が作動されたとき最初に突出させられ、次いで液体が針から押し出され、最後に針は自動的に引っ込められる。針は、バレル状の本体内で縦方向に滑動可能なカプセルから前方へ延びており、通常は相対的に力が弱いばねがカプセルと針を引っ込めた状態で維持している。より強力なばねが、ロッド部品（２７Ａ、２７Ｂ）によって構成されたプランジャに反対方向に作用し、プランジャは、解放されたときカプセル内の液体に作用することによってカプセルを前方へ急速移動させ、次いで突出している針から液体を押し出す。前進行程の終わりに、プランジャとカプセルは切り離されて、力が弱いばねが使用済みのカプセルとその針を引き込み位置に戻す。ロッド部品（２７Ａ）のピストン（３１）によって提供される空動接続が、ロッド部品（２７Ｂ）のシリンダ（３２）においてダンパーとして働いて、切り離しが生じる前に全投与量が針から排出されることを保証する。The injection device has a needle which is first protruded when the injection device is actuated, then liquid is pushed out of the needle and finally the needle is automatically retracted. The needle extends forward from a capsule that is slidable longitudinally within the barrel-like body, and a normally weak spring maintains the capsule and the needle retracted. A stronger spring acts in the opposite direction on the plunger constituted by the rod parts (27A, 27B), which, when released, rapidly moves the capsule forward by acting on the liquid in the capsule, then Push liquid out of protruding needle. At the end of the forward travel, the plunger and capsule are disconnected and a weak spring returns the used capsule and its needle back to the retracted position. The pneumatic connection provided by the piston (31) of the rod part (27A) acts as a damper in the cylinder (32) of the rod part (27B) so that the entire dose is drained from the needle before disconnection occurs Guarantee.

Description

本発明は、注射装置、特に針が引き込まれて使用後に安全にされる医療用注射装置に関するものである。   The present invention relates to an injection device, and more particularly to a medical injection device that is retracted and made safe after use.

そのような注射装置は、明白な理由で増大する需要のなかにある。大きな危険性が、汚染の可能性のある針を有して捨てられた注射器にある。使用後の針の引き込みが可能であるだけでなく自動的に行われることが非常に望まれている。非常に簡単に見逃され得るいくつかの操作によって使用者がそれを安全にすることに頼るべきではない。また、自己管理された薬物治療の増加する利用とともに、注射の前後において注射針が使用者に対して通常は可視的ではない装置に対する需要がある。   Such injection devices are in increasing demand for obvious reasons. A great risk lies in syringes that are thrown away with potentially contaminated needles. Not only is it possible to retract the needle after use, but it is highly desirable to be done automatically. The user should not rely on making it safe by a number of operations that can be overlooked very easily. There is also a need for devices where the needle is not normally visible to the user before and after injection, along with the increasing use of self-administered medication.

英国特許第７２８２４８号明細書に、これらの要件を満足する皮下注射装置が記載されている。しかしながら様々な実施例は相当に複雑なものであり、それ故高価であり、またそれらのいずれもがこれまでに一般に使用されていないと信じられる。その装置が注射の前後において安全であったとしてもそれは現在は不十分であり、つまりそれが一回使用されて次に廃棄されるほど好適に安くなければならない。   GB 728248 describes a hypodermic injection device that satisfies these requirements. However, the various embodiments are quite complex and therefore expensive, and it is believed that none of them has been commonly used to date. Even if the device is safe before and after injection, it is currently insufficient, i.e. it must be suitably cheap enough to be used once and then discarded.

英国特許第７２８２４８号の装置は、強力なばねを利用しており、前記ばねは解放されたときアンプルと針キャリアを押し進める。これが針を患者の肉体内に発射する。この段階の終わりに、ばねはキャリアから自動的に切り離されるが、アンプル内のピストンと協働するプランジャに引き続き作用する。従ってアンプルの内容物は、ばねによって針から搾り出される。この段階の終わりに、ばねはプランジャから自動的に切り離されて、アンプルと針キャリアを相対的に力が弱い復帰ばねによって作用されるままにし、前記復帰ばねはキャリアを引き込み位置に押しやる。従って二つの切り離しがあり、前記の複雑さは主としてこの二つの切り離しに起因する。   The device of GB 728248 utilizes a strong spring that pushes the ampoule and needle carrier when released. This fires the needle into the patient's body. At the end of this phase, the spring is automatically disconnected from the carrier, but continues to act on the plunger that cooperates with the piston in the ampoule. The contents of the ampoule are therefore squeezed out of the needle by the spring. At the end of this stage, the spring is automatically disconnected from the plunger, leaving the ampoule and the needle carrier acted upon by a relatively weak return spring, which pushes the carrier into the retracted position. There are therefore two separations, and the complexity is mainly due to the two separations.

これらの装置を越える改良が生み出されて、我々の欧州特許第０５１６４７３号明細書に記載されている。しかしながら、この装置でさえ投薬量の送出に関する問題を有することがある。注射器及び注射器プランジャ及び装置の他の機構の長さの公差は、薬剤の送出が完了する前に、早すぎる誘発が発生する結果にほとんど常に帰着する。本発明はこの問題を緩和することを目的とする。   Improvements over these devices have been created and are described in our European Patent No. 0516473. However, even this device may have problems with delivering the dosage. The length tolerances of the syringe and syringe plunger and other features of the device almost always result in a premature triggering before the drug delivery is complete. The present invention aims to alleviate this problem.

本発明によると、バレルと、バレルの中のばね荷重式駆動部材と、前記駆動部材をバレル内で前方へ跳ね返らせることを可能にする解放機構と、バレル内に装填されたばね荷重式カプセルと、カプセルに結合された針であって初期的にはバレルの前端で引き込み位置にある針と、前記駆動部材のばね荷重に対抗しているが前記ばね荷重より力が弱いカプセルのばね荷重と、前記駆動部材の前端が協働するプランジャと、前進行程の終わりに前記駆動部材からプランジャを切り離すための切離し機構とを含んで成る注射装置であって、前記前進行程は、第一にカプセルと針とを針突出位置まで駆動し、前記駆動部材はプランジャとカプセル装薬とを介して作用し、第二に前記前進行程は、カプセル装薬が針から排出されるようにプランジャを押しやり、次にカプセルを針引き込み位置に戻すためにカプセルのばね荷重が切離し機構によって解放され、またプランジャは二部品部分を、当該二部品部分の間の遅延運動接続と共に含み、該遅延運動接続は作動の際に、切離し機構が作動されるところの位置までのプランジャの全作動を、針から所要の装薬を排出するために必要な全行程をプランジャが完了する時まで遅らせるように働く注射装置が提供される。   In accordance with the present invention, a barrel, a spring loaded drive member in the barrel, a release mechanism that allows the drive member to bounce forward in the barrel, and a spring loaded capsule loaded in the barrel; A needle coupled to the capsule and initially in the retracted position at the front end of the barrel; and a capsule spring load that opposes the spring load of the drive member but is weaker than the spring load; An injection device comprising a plunger with which the front end of the drive member cooperates and a release mechanism for separating the plunger from the drive member at the end of a forward travel, wherein the forward travel is primarily a capsule and a needle And the drive member acts through the plunger and the capsule charge, and secondly, the forward travel pushes the plunger so that the capsule charge is discharged from the needle. And then the capsule spring load is released by the release mechanism to return the capsule to the needle retracted position, and the plunger includes a two-part portion with a delayed-motion connection between the two-part portions, An injection device that, in operation, serves to delay the full actuation of the plunger to the position where the detachment mechanism is actuated until the plunger completes the entire stroke required to eject the required charge from the needle. Is provided.

第一段階の終わりのときには切り離しは必要とされない。つまり比較的容易に針を突出させたばね荷重式駆動部材は、針を通してのみ排出されるカプセル装薬の抵抗に対抗してよりゆっくりと進む。遅延運動接続は、切離し機構が作動して、装薬の排出が止まる針引き込み位置にカプセルを戻す前に、所要の全液体装薬を針を通して排出するようにプランジャが作動することを保証する。   Detachment is not required at the end of the first stage. In other words, the spring-loaded drive member with the needle protruding relatively easily advances more slowly against the resistance of the capsule charge discharged only through the needle. The delayed motion connection ensures that the plunger is actuated to expel all required liquid charge through the needle before the release mechanism is actuated and the capsule is returned to the needle retracted position where discharge of the charge stops.

好適な装置では、二部品部分はダンパーを組み入れている。二部品部分は、ピストンとシリンダの形をしており、またダンパーはそのピストンのシリンダ内への行程の完了を遅らせるように働く。そのときダンパーは、シリンダの基部における通気穴、またはシリンダの内壁に接触するピストンの漏れやすいシールを含んで成る。   In a preferred device, the two-part part incorporates a damper. The two-part part is in the form of a piston and a cylinder, and the damper serves to delay the completion of the stroke of the piston into the cylinder. The damper then comprises a leaky seal of the piston in contact with the vent in the base of the cylinder or the inner wall of the cylinder.

カプセルは、都合よく独自開発された注射器であり、該注射器はそのプランジャが前記駆動部材と協働する前記プランジャによって取り外されて置き換えられている。   The capsule is conveniently a uniquely developed syringe, the syringe having its plunger removed and replaced by the plunger cooperating with the drive member.

好適には、ばね負荷は、バレル内の同軸なコイルばねによって提供される。   Preferably, the spring load is provided by a coaxial coil spring in the barrel.

切り離し手段は理想的には、前記駆動部材に当接する前記プランジャの後端に設けられ、またプランジャがカプセルと協働するようになるときプランジャは変形するように適合されている。例えばプランジャの後端は二又に分けられ、またそれにより形成されたフィンガに外側突起があり、前記突起は、カプセル内へ進入してカプセルに係合されたとき、フィンガをくさび作用で一体に押し付けて、この押し付けた状態で駆動部材内の通路に自由に進入させる。   Separating means are ideally provided at the rear end of the plunger abutting the drive member, and the plunger is adapted to deform when the plunger comes to cooperate with the capsule. For example, the rear end of the plunger is bifurcated, and the fingers formed thereby have outer projections that, when entering the capsule and engaged with the capsule, wedge the fingers together. By pressing, it is allowed to freely enter the passage in the drive member in this pressed state.

駆動部材は通常はキャッチを有しており、前記キャッチは初期的にはバレルに係合されて、エネルギーを与えられた前進ばねを保持している。ボタン状の後端キャップであり得る解放機構が、このキャッチを係合解除する。   The drive member typically has a catch, which is initially engaged with the barrel and holds an energized advance spring. A release mechanism, which can be a button-like rear end cap, disengages the catch.

本発明のよりよい理解のために、ここでいくつかの実施例が、例示を目的として添付図面を参照しながら説明される。   For a better understanding of the present invention, several embodiments will now be described by way of example with reference to the accompanying drawings.

図１〜４の注射装置は、前端へ向かって縮小している階段状バレル１を有しており、前端には使用の際に取り外されるキャップ２がある。後端にはキャップ３があり、前記キャップ３はその外周フランジによってスナップ嵌めされるものであり、また内側環帯４と中央タブ５を有している。キャップ３はバレル１において回転可能であり、またその中央部分は、外周近くの脆弱部６の効果によってバレルの軸方向に沿って内方へ撓曲されることが可能である。   The injection device of FIGS. 1-4 has a stepped barrel 1 that shrinks toward the front end, which has a cap 2 that is removed during use. There is a cap 3 at the rear end, and the cap 3 is snap-fitted by an outer peripheral flange, and has an inner annular band 4 and a central tab 5. The cap 3 can be rotated in the barrel 1 and its central part can be bent inward along the axial direction of the barrel by the effect of the weakened part 6 near the outer periphery.

バレルの最大直径部分７は、ボトル形駆動部材８を収容しており、前記ボトル形駆動部材８のネック部は後部の方にありまたボトル形駆動部材８はその基部に中央開口を有している。ネック部９は、二又に分けられて、内側に延びるフランジ１１によって形成された開口１０を通って延びている。そのフランジを越えて駆動部材８は、傾斜面１２を有する外側に曲げられたフックの形で終端し、前記傾斜面１２と内側環帯４が協働する。駆動部材８の反対側の前端には、外向きフランジ１３があり、また駆動部材を取り囲むコイルばね１４がこの外向きフランジ１３とフランジ１１との間で働く。図１に示されるように、駆動部材８がバレルの後部に捕捉された状態で、このばねはその最大圧縮状態にある。   The largest diameter portion 7 of the barrel accommodates a bottle-shaped drive member 8, the neck of the bottle-shaped drive member 8 being towards the rear and the bottle-shaped drive member 8 having a central opening at its base. Yes. The neck portion 9 is divided into two and extends through an opening 10 formed by an inwardly extending flange 11. Beyond that flange, the drive member 8 terminates in the form of an outwardly bent hook having an inclined surface 12, with the inclined surface 12 and the inner annulus 4 cooperating. At the front end on the opposite side of the drive member 8, there is an outward flange 13, and a coil spring 14 surrounding the drive member acts between the outward flange 13 and the flange 11. As shown in FIG. 1, with the drive member 8 trapped at the rear of the barrel, the spring is in its maximum compression state.

バレル１の後部分７と中間部分１５との間の移行部は、環状リブ１６によって内側に形成されている。この部分１５の前端に、別の環状リブ１７があり、また初期的に装填されたカプセル１８がこれらのリブによって位置決めされ、周囲のコイルばね１９がリブ１７に対して作用しかつカプセルの後部のフランジ２０をリブ１６に押し付ける。ばね１９はばね１４より若干力が弱く、またばね１９が圧縮されたとき、カプセルの前方への移動は、リブ１７から後方へ延在してフランジ２０に当接部を提供するスペーサ２１によって制限される。   The transition between the rear part 7 and the intermediate part 15 of the barrel 1 is formed inside by an annular rib 16. At the front end of this part 15 there is another annular rib 17 and the initially loaded capsule 18 is positioned by these ribs, the surrounding coil spring 19 acts against the rib 17 and the rear of the capsule The flange 20 is pressed against the rib 16. The spring 19 is slightly weaker than the spring 14 and, when the spring 19 is compressed, the forward movement of the capsule is limited by a spacer 21 that extends rearward from the rib 17 and provides an abutment for the flange 20. Is done.

カプセル１８の、針２２の付いた先導部分が、バレルの前端部分２３に配置されており、針の先端は端から後退している。初期的に針２２は、自己密封性シリコンゴム隔壁２４の中に包まれて汚染及び漏れから保護されている。隔壁は、キャップ２の内側管状延長部２５の中に閉じ込められていて、使用の直前にキャップが取り外されるときに引き外される。   The leading portion of the capsule 18 with the needle 22 is located at the front end portion 23 of the barrel and the tip of the needle is retracted from the end. Initially, the needle 22 is encased in a self-sealing silicone rubber septum 24 to protect it from contamination and leakage. The septum is confined within the inner tubular extension 25 of the cap 2 and is pulled off when the cap is removed just prior to use.

プランジャ２６が、二部品ロッド２７Ａ、２７Ｂ及びカプセル１８内のピストン２８によって構成されている。それらは接続されておらず、つまりピストンはカプセル１８に備えられ、カプセル１８は、注射装置の組立とは全く別に装薬を充填されてピストンによって栓をされる。ロッド２７の後端は二又に分けられて、末端の近くで、結果としてできたフィンガが拡大して、駆動部材８の環状基部が作用する外側座付き当接部２９を形成する。分岐部の根元の近くに、更なる拡大部３０が対向する両側にあって、該拡大部３０は次に説明されるようにフィンガの先端を共に閉じるためにカプセル１８の後端の中に楔のように入り込む傾斜面をもっている。ロッドの二部品２７Ａ及び２７Ｂはシリンダ３２内でピストン３１によって相互接続されている。   The plunger 26 is constituted by a two-part rod 27A, 27B and a piston 28 in the capsule 18. They are not connected, i.e. the piston is provided in a capsule 18, which is filled with the charge and plugged by the piston completely separate from the assembly of the injection device. The rear end of the rod 27 is bifurcated and the resulting finger expands near the distal end to form an outer seated abutment 29 on which the annular base of the drive member 8 acts. Near the root of the bifurcation, there are further enlargement portions 30 on opposite sides, the enlargement portion 30 wedges into the rear end of the capsule 18 to close the finger tips together as described next. It has an inclined surface that goes into. The two rod parts 27 A and 27 B are interconnected by a piston 31 in a cylinder 32.

使用するために、キャップ２は、それと共に隔壁２４を引き連れて取り外され、またキャップ３は、タブ５がフック１２を広げて保持してフランジ１１にしっかり係合させているところの図１の“安全”位置から９０度回転される。キャップ３は、図２、３及び４において“使用”位置で示されている。そして注射装置は、注射がなされるべきところにあてがわれてキャップ３の中央部が押される。環帯４が両方のフック１２に共に楔作用を与えてそれらをフランジ１１から自由にする。次いでばね１４が自由になって作動し、またばねは駆動部材８を前方へ発射する。カプセル内の流体は、実質的に非圧縮性であり、またそれは針２２を通る非常に狭い漏出手段を有する。プランジャ２６は従って実質的に硬い本体に作用し、またプランジャ２６はカプセル１８を前方に運んでばね１９を圧縮する。この作動は図２に示されているように終わり、針１８が突き出てフランジ２０がスペーサ２１に当接する。   For use, the cap 2 is removed with it pulling the septum 24 with it, and the cap 3 is shown in FIG. 1 with the tab 5 holding the hook 12 unfolded and firmly engaging the flange 11. Rotated 90 degrees from "safe" position. The cap 3 is shown in the “used” position in FIGS. The injection device is applied to the place where injection is to be performed, and the center portion of the cap 3 is pushed. Annulus 4 provides a wedge action to both hooks 12 to free them from flange 11. The spring 14 is then actuated free and the spring fires the drive member 8 forward. The fluid in the capsule is substantially incompressible and it has a very narrow leak means through the needle 22. The plunger 26 thus acts on a substantially rigid body and the plunger 26 carries the capsule 18 forward and compresses the spring 19. This operation ends as shown in FIG. 2, and the needle 18 protrudes and the flange 20 abuts against the spacer 21.

カプセル１８が止められた状態で、プランジャ２６が主要なばね１４の影響を受けて前進して液体を針２２から押し出す。プランジャ２６が前進行程の端に達したとき（図３）、楔３０はロッド部品２７Ａの二又にされた端部を共に圧迫するように作用し、その結果当接部２９を駆動部材８の基部における開口の範囲内にもってくる。この時点で、駆動部材８はリブ１６によって止められ、次にばね１９が作動可能になってカプセル１８を運び戻し、フランジ２０がリブ１６の前側に当接するまでロッド端部２７Ａが駆動部材８の中に入る（図４）。これはカプセルの初期位置であり、また針はバレル内にあって安全である。しかしながら、注射装置の部品の幾何公差及び寸法公差は、所要の全ての装薬がカプセル１８から排出される前に、当接部２９が駆動部材８に進入するところの位置にプランジャロッド２６が達するようなものであり得る。これを防ぐために、シリンダ３２内でのピストン３１の配置構成は、遅延運動接続を生み出すようになっており、前記遅延運動接続により楔３０のカプセル１８への進入を引き起こすプランジャ２６の全行程は、ロッド部品２７Ｂが十分遠くまで移動して所要量の装薬をカプセル１８から排出するまで遅らせられる。ロッドの二部品２７Ａと２７Ｂとの間の遅延運動接続は図５に詳細に示されている。ピストン３１がリングシール３３を装着していることが見られる。ピストン３０のシリンダ３２内での移動の遅延運動作用を達成する一つの手段は、シール３３を“漏れやすい”シールとして作ることである。更に又は代わりに、制御された通気穴３４をシリンダ３２の基部に設けることが可能である。遅延運動接続は、ロッド部品２７Ｂが注射器を完全に空にする時まで作動するように配置構成される。そのときロッド部品２７Ａは、それがロッド部品２７Ｂの頂部に当接するまでカプセル１８内で駆動され続け、その結果楔３０はカプセル１８と相互作用をして、（図３におけるように）当接部２９が駆動部材８から解放されることを可能にする。   With the capsule 18 stopped, the plunger 26 advances under the influence of the main spring 14 to push the liquid out of the needle 22. When the plunger 26 reaches the end of the forward travel (FIG. 3), the wedge 30 acts to squeeze together the bifurcated end of the rod part 27A, so that the abutment 29 is brought into contact with the drive member 8. Bring within the opening of the base. At this point, the drive member 8 is stopped by the rib 16, and then the spring 19 is actuated to carry the capsule 18 back and the rod end 27 </ b> A is on the drive member 8 until the flange 20 contacts the front side of the rib 16. Go inside (Figure 4). This is the initial position of the capsule and the needle is in the barrel and is safe. However, the geometrical and dimensional tolerances of the parts of the injection device are such that the plunger rod 26 reaches a position where the abutment 29 enters the drive member 8 before all the required charge is discharged from the capsule 18. It can be like that. In order to prevent this, the arrangement of the piston 31 in the cylinder 32 is designed to create a delayed motion connection, and the entire stroke of the plunger 26 causing the wedge 30 to enter the capsule 18 by the delayed motion connection is: The rod part 27B is delayed until it has moved far enough to discharge the required amount of charge from the capsule 18. The retarded motion connection between the two rod parts 27A and 27B is shown in detail in FIG. It can be seen that the piston 31 is fitted with a ring seal 33. One means of achieving a delayed action of movement of the piston 30 within the cylinder 32 is to make the seal 33 as a “leaky” seal. Additionally or alternatively, a controlled vent 34 can be provided at the base of the cylinder 32. The delayed motion connection is arranged to operate until the rod part 27B is completely emptied of the syringe. The rod part 27A then continues to be driven within the capsule 18 until it abuts the top of the rod part 27B, so that the wedge 30 interacts with the capsule 18 (as in FIG. 3). 29 can be released from the drive member 8.

（保管中において、特に針の先端が最も上にあるとき）ロッド部品２７Ｂがロッド部品２７Ａの中へゆっくり移動する可能性を排除するために、リブ３７と３８との間の軽いクリップかみ合いがある。これらのリブは、注射装置が作動されたときばね１４によって容易に無効にされる。   There is a light clip engagement between the ribs 37 and 38 to eliminate the possibility of the rod part 27B moving slowly into the rod part 27A (in storage, especially when the needle tip is at the top). . These ribs are easily disabled by the spring 14 when the injection device is activated.

薬剤は、在来の注射器に類似しているが端部のフランジがないカートリッジ内にプリパッケージされて現在入手可能である。そのようなカートリッジはキャップを有しており、前記キャップは、両端針を受入れる縮小された直径の分配端に穿孔可能なゴム皮膜を有するものである。これはシールドの内側に包装され、前記シールドはそれが安全且つ容易に取り付けられることを可能にし、並びに一時的な保護をそれに与える。それを前述された注射装置に使用できるようにするフランジを提供するために、カートリッジはスリーブ状キャリアの内側に嵌めこまれることがある。これは、カートリッジの分配端を取り囲むネック部及び反対側の端のフランジ２０の機能を果たす外側に突出したフランジと同じ外形にされる。針を保持するためにネック部にねじ山を付けることが可能である。   The drug is currently available prepackaged in a cartridge similar to a conventional syringe but without an end flange. Such cartridges have a cap, which has a rubber coating that can be pierced at a reduced diameter dispensing end that accepts a double-ended needle. This is packaged inside the shield, which allows it to be safely and easily attached and provides it with temporary protection. The cartridge may be fitted inside a sleeve-like carrier to provide a flange that allows it to be used with the previously described injection device. This is profiled with an outwardly projecting flange that acts as a neck around the dispensing end of the cartridge and a flange 20 at the opposite end. It is possible to thread the neck to hold the needle.

作動の進行段階にある注射装置の縦断面図である。It is a longitudinal cross-sectional view of the injection device in an advanced stage of operation. 作動の進行段階にある注射装置の縦断面図である。It is a longitudinal cross-sectional view of the injection device in an advanced stage of operation. 作動の進行段階にある注射装置の縦断面図である。It is a longitudinal cross-sectional view of the injection device in an advanced stage of operation. 作動の進行段階にある注射装置の縦断面図である。It is a longitudinal cross-sectional view of the injection device in an advanced stage of operation. 図１〜４の装置のプランジャの一部の拡大詳細断面図である。5 is an enlarged detailed cross-sectional view of a portion of the plunger of the apparatus of FIGS.

Claims (11)

バレルと、バレルの中のばね荷重式駆動部材と、前記駆動部材をバレル内で前方へ跳ね返らせることを可能にする解放機構と、バレル内に装填されたばね荷重式カプセルと、カプセルに結合された針であって初期的にはバレルの前端で引き込み位置にある針と、前記駆動部材のばね荷重に対抗しているが前記ばね荷重より力が弱いカプセルのばね荷重と、前記駆動部材の前端が協働するプランジャと、前進行程の終わりに前記駆動部材からプランジャを切り離すための切離し機構とを含んで成る注射装置であって、
前記前進行程は、第一にカプセルと針とを針突出位置まで駆動し、前記駆動部材はプランジャとカプセル装薬とを介して作用し、第二に前記前進行程は、カプセル装薬が針から排出されるようにプランジャを押しやり、次にカプセルを針引き込み位置に戻すためにカプセルのばね荷重が切離し機構によって解放され、またプランジャは二部品部分を、当該二部品部分の間の遅延運動接続と共に含み、該遅延運動接続は作動の際に、切離し機構が作動されるところの位置までのプランジャの全作動を、針から所要の装薬を排出するために必要な全行程をプランジャが完了する時まで遅らせるように働く注射装置。 A barrel, a spring-loaded drive member in the barrel, a release mechanism that allows the drive member to bounce forward in the barrel, a spring-loaded capsule loaded in the barrel, and coupled to the capsule A needle that is initially in the retracted position at the front end of the barrel, a spring load of the capsule that opposes the spring load of the drive member but is weaker than the spring load, and a front end of the drive member An injection device comprising:
The forward travel first drives the capsule and the needle to the needle projecting position, the drive member acts via the plunger and the capsule charge, and secondly, the forward charge travels from the needle to the capsule charge. The spring load of the capsule is released by the release mechanism to push the plunger to be ejected and then return the capsule to the needle retracted position, and the plunger also connects the two-part part with a delayed motion connection between the two-part parts. The delay movement connection, in operation, completes the full operation of the plunger to the position where the decoupling mechanism is activated, completing the entire stroke required to eject the required charge from the needle. An injection device that works to delay until time. 前記二部品部分がダンパーを組み込んでいる、請求項１に記載の注射装置。   The injection device of claim 1, wherein the two-part portion incorporates a damper. 二部品部分がピストンとシリンダの形態をしていて、ダンパーが、前記ピストンのシリンダ内での行程の完了を遅らせるように働く、請求項２に記載の注射装置。   The injection device according to claim 2, wherein the two-part part is in the form of a piston and a cylinder, and the damper serves to delay the completion of the stroke of the piston in the cylinder. ダンパーがシリンダの基部に通気穴を含んで成る、請求項３に記載の注射装置。   4. An injection device according to claim 3, wherein the damper comprises a vent hole in the base of the cylinder. シリンダの内壁に接触する、ピストンの漏れやすいシールをダンパーが含んで成る、請求項３に記載の注射装置。   4. The injection device of claim 3, wherein the damper comprises a leaky seal for the piston that contacts the inner wall of the cylinder. カプセルが、独自開発された注射器であって、該独自開発された注射器のプランジャが前記駆動部材と協働する前記プランジャによって取り外されて置き換えられた独自開発された注射器である、請求項１〜５のいずれか一項に記載の注射装置。   The capsule is a uniquely developed syringe, wherein the plunger of the uniquely developed syringe is a uniquely developed syringe that has been removed and replaced by the plunger cooperating with the drive member. The injection device according to any one of the above. ばね荷重が、バレル内で同軸のコイルばねによって提供される、請求項１〜６のいずれか一項に記載の注射装置。   The injection device according to any one of the preceding claims, wherein the spring load is provided by a coaxial coil spring in the barrel. 切離し機構が、前記駆動部材によって当接される前記プランジャの後端により提供され、また前記プランジャは、それがカプセルと協働するようになったとき変形されるように適合されたものである、請求項１〜７のいずれか一項に記載の注射装置。   A decoupling mechanism is provided by the rear end of the plunger abutted by the drive member, and the plunger is adapted to be deformed when it comes to cooperate with the capsule. The injection device according to any one of claims 1 to 7. プランジャの前記後端が二又に分けられ、そのことによって形成されたフィンガに外側突起があり、前記突起が、カプセル内に進入してカプセルによって係合されたとき、フィンガをくさび作用で一体に押さえ付けて、押さえ付けた状態で、駆動部材内の通路に自由に進入させる、請求項８に記載の注射装置。   The rear end of the plunger is bifurcated, and the finger formed thereby has an outer protrusion, and when the protrusion enters the capsule and is engaged by the capsule, the fingers are wedged together. The injection device according to claim 8, wherein the injection device is allowed to freely enter the passage in the drive member while being pressed. 添付の図面を参照して、本明細書で実質的に説明された注射装置。   An injection device substantially as herein described with reference to the accompanying drawings. 本明細書で説明された及び／又は添付の図面で図解された注射装置の特徴の任意の新規な組み合わせ体。   Any novel combination of features of the injection device described herein and / or illustrated in the accompanying drawings.
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