JP2005523718A5 - - Google Patents
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- Publication number
- JP2005523718A5 JP2005523718A5 JP2004501545A JP2004501545A JP2005523718A5 JP 2005523718 A5 JP2005523718 A5 JP 2005523718A5 JP 2004501545 A JP2004501545 A JP 2004501545A JP 2004501545 A JP2004501545 A JP 2004501545A JP 2005523718 A5 JP2005523718 A5 JP 2005523718A5
- Authority
- JP
- Japan
- Prior art keywords
- seq
- nucleic acid
- copy
- isolated polynucleotide
- factor
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 238000000034 method Methods 0.000 claims 33
- 150000007523 nucleic acids Chemical class 0.000 claims 24
- 108091033319 polynucleotide Proteins 0.000 claims 21
- 102000040430 polynucleotide Human genes 0.000 claims 21
- 239000002157 polynucleotide Substances 0.000 claims 21
- 108091028043 Nucleic acid sequence Proteins 0.000 claims 14
- 239000003623 enhancer Substances 0.000 claims 14
- 102000039446 nucleic acids Human genes 0.000 claims 10
- 108020004707 nucleic acids Proteins 0.000 claims 10
- 206010021143 Hypoxia Diseases 0.000 claims 9
- 230000033115 angiogenesis Effects 0.000 claims 8
- 210000002889 endothelial cell Anatomy 0.000 claims 7
- 210000004027 cell Anatomy 0.000 claims 6
- 230000007954 hypoxia Effects 0.000 claims 6
- 238000001727 in vivo Methods 0.000 claims 6
- 108010081589 Becaplermin Proteins 0.000 claims 5
- 102000005789 Vascular Endothelial Growth Factors Human genes 0.000 claims 5
- 108010019530 Vascular Endothelial Growth Factors Proteins 0.000 claims 5
- 108020003519 protein disulfide isomerase Proteins 0.000 claims 5
- 108091023040 Transcription factor Proteins 0.000 claims 4
- 102000040945 Transcription factor Human genes 0.000 claims 4
- 210000003038 endothelium Anatomy 0.000 claims 4
- 210000003527 eukaryotic cell Anatomy 0.000 claims 3
- 230000001146 hypoxic effect Effects 0.000 claims 3
- 230000009885 systemic effect Effects 0.000 claims 3
- 210000001519 tissue Anatomy 0.000 claims 3
- 108700028146 Genetic Enhancer Elements Proteins 0.000 claims 2
- 210000004962 mammalian cell Anatomy 0.000 claims 2
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 239000002773 nucleotide Substances 0.000 claims 1
- 125000003729 nucleotide group Chemical group 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US10/135,447 US7067649B2 (en) | 2000-11-17 | 2002-05-01 | Promoters exhibiting endothelial cell specificity and methods of using same |
| PCT/IL2003/000347 WO2003093409A2 (en) | 2002-05-01 | 2003-04-30 | Promoters exhibiting endothelial cell specificity and methods of using same |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2005523718A JP2005523718A (ja) | 2005-08-11 |
| JP2005523718A5 true JP2005523718A5 (https=) | 2006-05-25 |
Family
ID=29399218
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2004501545A Pending JP2005523718A (ja) | 2002-05-01 | 2003-04-30 | 内皮細胞特異性を示すプロモーター及びその使用法 |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US7067649B2 (https=) |
| EP (1) | EP1527084A4 (https=) |
| JP (1) | JP2005523718A (https=) |
| KR (1) | KR20040104685A (https=) |
| CN (1) | CN1703420A (https=) |
| CA (1) | CA2483996A1 (https=) |
| MX (1) | MXPA04010711A (https=) |
| WO (1) | WO2003093409A2 (https=) |
| ZA (1) | ZA200408989B (https=) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8071740B2 (en) * | 2000-11-17 | 2011-12-06 | Vascular Biogenics Ltd. | Promoters exhibiting endothelial cell specificity and methods of using same for regulation of angiogenesis |
| US20070286845A1 (en) * | 2000-11-17 | 2007-12-13 | Vascular Biogenics Ltd. | Promoters exhibiting endothelial cell specificity and methods of using same for regulation of angiogenesis |
| US20100282634A1 (en) * | 2000-11-17 | 2010-11-11 | Dror Harats | Promoters Exhibiting Endothelial Cell Specificity and Methods of Using Same for Regulation of Angiogenesis |
| AU2003222427B8 (en) * | 2000-11-17 | 2010-04-29 | Vascular Biogenics Ltd. | Promoters exhibiting endothelial cell specificity and methods of using same |
| US8039261B2 (en) * | 2000-11-17 | 2011-10-18 | Vascular Biogenics Ltd. | Promoters exhibiting endothelial cell specificity and methods of using same for regulation of angiogenesis |
| US6838452B2 (en) * | 2000-11-24 | 2005-01-04 | Vascular Biogenics Ltd. | Methods employing and compositions containing defined oxidized phospholipids for prevention and treatment of atherosclerosis |
| CN100506284C (zh) * | 2001-10-19 | 2009-07-01 | 脉管生物生长有限公司 | 多核苷酸构建体、药物组合物以及靶向的下调血管生成和抗癌的治疗方法 |
| AU2011205076B2 (en) * | 2004-11-14 | 2012-03-15 | Vascular Biogenics Ltd. | Promoters Exhibiting Endothelial Cell Specificity and Methods of Using Same for Regulation of Angiogenesis |
| US20060148695A1 (en) * | 2005-01-03 | 2006-07-06 | National Cheng Kung University | Novel angiogenic composition and use thereof |
| US20070161031A1 (en) * | 2005-12-16 | 2007-07-12 | The Board Of Trustees Of The Leland Stanford Junior University | Functional arrays for high throughput characterization of gene expression regulatory elements |
| EP2051988A4 (en) | 2006-07-31 | 2010-06-02 | Vascular Biogenics Ltd | POLYPEPTIDES AND THESE CODING POLYNUCLEOTIDES AND THEIR USE IN THE TREATMENT OF MEDICAL DISEASES RELATED TO ISCHEMIA |
| EP2135080A4 (en) * | 2007-03-08 | 2010-12-01 | Switchgear Genomics | FUNCTIONAL NETWORKS FOR THE CHARACTERIZATION OF TREATMENT OF REGULATORY ELEMENTS IN NON-TRANSLATED REGIONS OF GENES |
| MX2010003371A (es) | 2007-09-28 | 2010-05-05 | Intrexon Corp | Constructos interruptores genicos terapeuticos y biorreactores para la expresion de moleculas bioterapeuticas y usos de los mismos. |
| US8815779B2 (en) | 2009-09-16 | 2014-08-26 | SwitchGear Genomics, Inc. | Transcription biomarkers of biological responses and methods |
| NZ601324A (en) * | 2010-01-05 | 2014-10-31 | Vascular Biogenics Ltd | Methods for use of a specific anti-angiogenic adenoviral agent |
| AU2011204407B2 (en) | 2010-01-05 | 2015-05-07 | Vascular Biogenics Ltd. | Compositions and methods for treating glioblastoma GBM |
| PL2908865T3 (pl) | 2012-10-17 | 2019-08-30 | Vascular Biogenics Ltd. | Adenowirus wykazujący ekspresję chimery Fas i jego zastosowanie w sposobach leczenia raka |
| WO2014123749A1 (en) | 2013-01-30 | 2014-08-14 | Board Of Regents Of The University Of Nebraska | Compositions and methods for treating complications associated with diabetes |
| EP2951307B1 (en) | 2013-02-04 | 2019-12-25 | Vascular Biogenics Ltd. | Methods of inducing responsiveness to anti-angiogenic agent |
| WO2021095809A1 (ja) * | 2019-11-15 | 2021-05-20 | 国立大学法人大阪大学 | 心不全に応答するエンハンサーポリヌクレオチド、及び前記エンハンサーポリヌクレオチドを含む発現ベクター |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5747340A (en) * | 1994-06-03 | 1998-05-05 | Syntex (U.S.A.) Inc. | Targeted gene expression using preproendothelin-1 promoters |
| CA2337496A1 (en) * | 1998-07-27 | 2000-02-10 | Valentis, Inc. | Anti-angiogenesis plasmids and delivery systems, and methods of making and using the same |
| ES2425321T3 (es) * | 2000-11-17 | 2013-10-14 | Vascular Biogenics Ltd. | Promotores que muestran especificidad por células endoteliales y métodos de utilización de los mismos |
-
2002
- 2002-05-01 US US10/135,447 patent/US7067649B2/en not_active Expired - Lifetime
-
2003
- 2003-04-30 KR KR10-2004-7017592A patent/KR20040104685A/ko not_active Ceased
- 2003-04-30 WO PCT/IL2003/000347 patent/WO2003093409A2/en not_active Ceased
- 2003-04-30 EP EP03717516A patent/EP1527084A4/en not_active Withdrawn
- 2003-04-30 CA CA002483996A patent/CA2483996A1/en not_active Abandoned
- 2003-04-30 JP JP2004501545A patent/JP2005523718A/ja active Pending
- 2003-04-30 MX MXPA04010711A patent/MXPA04010711A/es not_active Application Discontinuation
- 2003-04-30 CN CNA038152622A patent/CN1703420A/zh active Pending
-
2004
- 2004-11-05 ZA ZA200408989A patent/ZA200408989B/en unknown
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