JP2005523317A5 - - Google Patents

Claims (20)

  An agent for treating microbial nail infections that contains an antibacterial effective amount of copper silicate.   The drug according to claim 1, wherein the microbial infection is a fungal infection.   The medicament according to claim 1 or 2, wherein the infection comprises an infection of at least one dermatophyte.   The dermatophytes are Trichophyton mentagrophytes (including Mentagrophytes subspecies and Interdigitalales subspecies), Trichophyton rubrum, Trichophyton megnini, Trichophyton schönleinii, and Trichophyton tonlances The drug according to claim 3, which is selected from the group consisting of:   The infection includes at least species belonging to the genus Candida such as Candida albicans, Candida glabrata, Candida siferlii; species belonging to the genus Microsporum including Microsporum canis and Microsporum gypseum; Species belonging to the genus Malassezia; species belonging to the genus Epidermophyton such as epidermophyton floccosm; species belonging to the genus scoplalosis; species belonging to the genus Acremonium and species belonging to the genus Aspergillus The medicament according to claim 1 or 2, comprising:   The drug according to any one of claims 1 to 5, wherein the drug contains at least 1 to 100 µg of copper.   The agent according to any one of claims 1 to 6, wherein the agent comprises at least 2 to 50 µg of copper.   8. A drug according to any preceding claim, wherein the drug comprises at least 10 [mu] g copper.   9. Medicament according to any of the preceding claims, wherein the medicament has been adapted for use at least 1 to 3 times a day.   10. Medicament according to any of the preceding claims, wherein the medicament has been adapted for use at least once every 2-14 days.   The method according to any one of claims 1 to 10, wherein the drug is a topical drug.   Onychomycosis, Distal nail mycosis, Superwhite nail mycosis, Proximal white matter layer onychomycosis; Total secondary dystrophy onychomycosis; and Total primary dystrophy onychomycosis An agent for treating or preventing a disease selected from the group consisting of: an antibacterial effective amount of copper silicate.   An agent for treating or preventing onychomycosis comprising an antibacterial effective amount of copper silicate.   14. A method according to claim 12 or 13, wherein the drug is a topical drug.   A composition adapted for topical administration to the nail comprising an antimicrobially effective amount of copper silicate.   16. A composition according to claim 15, which is in the form of a solution.   The composition of claim 16 in the form of an aqueous acidified solution.   16. A composition according to claim 15, which is in the form of a cream.   A method for producing a copper silicate composition adapted for topical administration comprising dissolving or mixing copper silicate in an aqueous or non-aqueous topical carrier.   The composition according to any one of claims 15 to 18, comprising about 100 mg / L to 10 g / L as Cu.