JP2005513161A5

JP2005513161A5 -

Info

Publication number: JP2005513161A5
Application number: JP2003556555A
Authority: JP
Filing date: 2002-12-30
Publication date: 2005-12-22
Anticipated expiration: 2022-12-30

Claims

A method for recovering mannose from a solution derived from biomass, wherein the method comprises at least one chromatographic separation resin bed substantially in the Ba ²⁺ type and a solution other than the Ba ²⁺ type in the solution. Subjecting to a chromatographic separation process using at least one chromatographic separation resin bed and recovering at least one mannose fraction.

The chromatographic separation process comprises at least two chromatographic separation steps, at least one of which is performed using a chromatographic separation resin bed that is substantially of the Ba ²⁺ type, and these The method of claim 1, wherein at least one of the steps is performed using a chromatographic separation resin bed other than Ba ²⁺ type.

Feeding a solution derived from biomass into a first chromatography column comprising a chromatographic separation resin bed of substantially Ba ²⁺ type; eluting the column with an eluent; Recovering one mannose fraction and then feeding the first mannose fraction into a second chromatography column comprising a chromatographic separation resin bed other than Ba ²⁺ type, 3. The method of claim 2, comprising eluting with an eluent and recovering the second mannose fraction.

The chromatographic separation process consists of two separation steps using a chromatographic separation resin bed that is substantially of Ba ²⁺ type and one separation step using a chromatographic separation resin bed other than the Ba ²⁺ type. The method of claim 2.

Feeding a solution derived from biomass into a first chromatography column comprising a chromatographic separation resin bed of substantially Ba ²⁺ type; eluting the column with an eluent; Collecting 1 mannose fraction,
Feeding the first mannose fraction into a second chromatography column comprising a chromatographic separation resin bed of substantially Ba ²⁺ type, eluting the column with an eluent; Collecting a second mannose fraction;
And thereafter, feeding the second mannose fraction into a third chromatography column containing a chromatographic separation resin bed other than Ba ²⁺ , eluting the column with an eluent; 5. The method according to claim 4, further comprising recovering the third mannose fraction.

The method according to claim 1, wherein the resin bed other than the Ba ²⁺ type is in a cation form selected from hydrogen, NH ⁴⁺ , an alkali metal cation and an alkaline earth metal cation.

7. A method according to claim 6, wherein the cation is selected from NH4 ⁺ , Na ⁺ , K ⁺ , Mg2 ⁺ and Ca2 ⁺ .

The method of claim 1, wherein the chromatographic separation process is performed using a strongly acidic cation exchange resin.

The process according to claim 1, wherein the chromatographic separation process yields a mannose fraction having a mannose of 45 to 80% purity based on RDS.

The method according to claim 1, wherein the chromatographic separation process yields a mannose fraction having a purity of 80% or more based on RDS.

The method of claim 1 wherein the chromatographic separation process yields a mannose fraction comprising mannose and additional sugars selected from arabinose, xylose, galactose, rhamnose and fructose.

The method further comprises including one or more purification steps selected from membrane filtration, ion exchange, evaporation, filtration and derivatization performed before, after or during the chromatographic separation step / step group. The method of claim 1.

13. The method of claim 12, wherein the derivatization comprises forming N-phenyl-D-mannopyranosylamine as a mannose derivative.

The method of claim 1, wherein said method further comprises crystallizing mannose to obtain a crystalline mannose product.

15. The method of claim 14, wherein the crystallization is performed using a solvent selected from water, alcohol, and a mixture of water and alcohol.

The method according to claim 15, wherein the crystallization is performed using a mixture of ethanol and water.

The method according to claim 15, wherein the crystallization is performed using water.

The method according to claim 14, wherein the crystallization yields crystalline mannose having a purity of 90% or more based on RDS.

The method according to claim 14, wherein the crystallization yields crystalline mannose having a purity of 95% or more based on RDS.

The method according to claim 14, wherein the crystallization yields crystalline mannose having a purity of 99% or more based on RDS.

15. The method of claim 14, wherein the crystallization yields crystalline mannose having a purity of 90% to 99.9% based on RDS.

The method of claim 1, wherein the method further comprises separation of other sugars.

23. The method of claim 22, wherein the method comprises xylose separation as a pretreatment step.

24. The method of claim 23, wherein the xylose separation is performed by crystallization .

23. The method of claim 22, wherein the method further comprises separation of arabinose.

26. The method of claim 25, wherein the separation of arabinose is performed prior to precipitation crystallization of xylose.

27. The method of claim 25 or 26, wherein the separation of the arabinose is performed by a chromatographic separation process to recover the arabinose fraction.

28. The method of claim 27, wherein the chromatographic separation is performed using a chromatographic separation resin bed in monovalent cationic form.

29. The method of claim 28, wherein the monovalent cation is selected from hydrogen, ammonium and alkali metal cations.

The cation is, H ^+, NH ₄ ^+, The method of claim 29, wherein is selected from Na ⁺ and K ^+.

28. The method of claim 27, wherein the method further comprises chromatographic purification of the arabinose fraction.

32. The method of claim 31, wherein the chromatographic purification of the arabinose fraction comprises at least one step using a chromatographic separation resin bed in alkaline earth metal cation form.

The method of claim 32, wherein the alkaline earth metal is Ca ²⁺ .

28. The method of claim 27, wherein the separation of arabinose is performed using a strongly acidic cation exchange resin.

The method according to claim 22, wherein the method further comprises separation of rhamnose as a pretreatment step.

36. The method of claim 35, wherein the separation of rhamnose is performed prior to the separation of arabinose.

The method of claim 1, wherein the biomass-derived solution is a biomass hydrolyzate comprising mannose and additional sugars selected from xylose, arabinose, rhamnose, galactose, glucose and fructose.

The method of claim 1, wherein the biomass-derived solution is a biomass hydrolyzate comprising mannose and additional sugars selected from xylose, arabinose and rhamnose.

The method according to claim 1, wherein the solution derived from biomass is a hydrolyzate derived from mannose-containing plant material.

The method according to claim 1, wherein the solution derived from biomass is a hydrolyzate derived from lignocellulosic material.

The method according to claim 1, wherein the solution derived from biomass is a hydrolyzate derived from soft wood or hard wood.

38. The method of claim 37, wherein the solution derived from biomass is an old sulphite pulping solution.

43. The method of claim 42, wherein the old sulphite pulping solution is an old sulphite pulping solution recovered after rhamnose separation.

44. The method of claim 43, wherein the old sulphite pulping solution is an old sulphite pulping solution recovered after separation of xylose.

The method of claim 1, wherein the mannose is D-mannose.

A mannose solution comprising a chromatographic mannose fraction comprising mannose and a further sugar selected from arabinose, xylose, galactose, rhamnose and fructose.

Crystallinity having a purity of 90% or more based on RDS, derived from plant material and produced by crystallization from mannose and mannose solution containing additional sugars selected from arabinose, xylose, galactose, rhamnose and fructose Mannose.

48. Crystalline mannose according to claim 47, produced from a mannose solution comprising mannose and a further sugar selected from xylose.

48. Crystalline mannose according to claim 47, produced from a mannose solution comprising mannose and a further sugar selected from galactose.

48. Crystalline mannose according to claim 47, produced from a mannose solution comprising mannose and a further sugar selected from arabinose.

48. The crystalline mannose of claim 47, derived from a lignocellulosic material.

48. The crystalline mannose of claim 47, derived from soft wood or hard wood.

48. The crystalline mannose of claim 47, having a purity of 95% or more based on RDS.

48. The crystalline mannose of claim 47, having a purity of 99% or more based on RDS.

48. Crystalline mannose according to claim 47, which is D-mannose.