JP2005314411A5 - Structure - Google Patents
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- Publication number
- JP2005314411A5 JP2005314411A5 JP2005104831A JP2005104831A JP2005314411A5 JP 2005314411 A5 JP2005314411 A5 JP 2005314411A5 JP 2005104831 A JP2005104831 A JP 2005104831A JP 2005104831 A JP2005104831 A JP 2005104831A JP 2005314411 A5 JP2005314411 A5 JP 2005314411A5
- Authority
- JP
- Japan
- Prior art keywords
- lid member
- captures
- specifically recognizes
- gold
- connection
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000001875 compounds Chemical class 0.000 claims description 2
- PCHJSUWPFVWCPO-UHFFFAOYSA-N gold Chemical compound [Au] PCHJSUWPFVWCPO-UHFFFAOYSA-N 0.000 claims 9
- 239000010931 gold Substances 0.000 claims 9
- 229910052737 gold Inorganic materials 0.000 claims 9
- 102000004965 antibodies Human genes 0.000 claims 8
- 108090001123 antibodies Proteins 0.000 claims 8
- 125000003275 alpha amino acid group Chemical group 0.000 claims 6
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims 4
- 229910052814 silicon oxide Inorganic materials 0.000 claims 4
- 150000001413 amino acids Chemical class 0.000 claims 2
- 239000000126 substance Substances 0.000 description 1
Description
本発明は、多孔質体と、蓋部材と、蓋部材により多孔質体に保持された物質と、多孔質体と蓋部材を接続する接続部材とを有する構造体及びその構造体に関する。 The invention also relates to a porous body, a lid member, a substance held in the porous body by the lid member, the structure and the structure and a connecting member connecting the porous body and the lid member.
上述のような課題を解決すべく本発明者らは鋭意研究の結果、以下の構造体の構成が好適であることを見出した。すなわち、本発明の構造体は、化合物を内部に保持する構造体であって、
前記構造体が、
多孔質体と、蓋部材と、前記蓋部材と前記多孔質体とを接続する接続部材とを有し、
前記接続部材のうちの前記蓋部材との接続部分が、前記蓋部材を特異的に認識して捕捉する捕捉体を含む
もしくは
前記接続部材のうちの前記多孔質体との接続部分が、前記多孔質体を特異的に認識して捕捉する捕捉体を含むことを特徴とする。
As a result of diligent research, the present inventors have found that the following structures are suitable for solving the above-described problems. That is, the structure of the present invention is a structure that holds a compound therein,
The structure is
A porous body, a lid member, and a connecting member for connecting the lid member and the porous body;
The connection part of the connection member with the lid member includes a capturing body that specifically recognizes and captures the lid member.
Or
Of the connection member, a connection portion with the porous body includes a capturing body that specifically recognizes and captures the porous body .
Claims (7)
前記構造体が、
多孔質体と、蓋部材と、前記蓋部材と前記多孔質体とを接続する接続部材とを有し、
前記接続部材のうちの前記蓋部材との接続部分が、前記蓋部材を特異的に認識して捕捉する捕捉体を含む
もしくは
前記接続部材のうちの前記多孔質体との接続部分が、前記多孔質体を特異的に認識して捕捉する捕捉体を含む
ことを特徴とする構造体。 A structure that holds a compound therein,
The structure is
A porous body, a lid member, and a connecting member for connecting the lid member and the porous body;
The connection part of the connection member with the lid member includes a capturing body that specifically recognizes and captures the lid member.
Or
A structure, wherein a connection portion of the connection member with the porous body includes a capturing body that specifically recognizes and captures the porous body.
前記蓋部材の少なくとも一部が金で構成され、
前記蓋部材を特異的に認識して捕捉する捕捉体が金を特異的に認識して捕捉する抗体可変領域を有する捕捉体であることを特徴とする請求項１に記載の構造体。 The connection part with the lid member of the connection member includes a capturing body that specifically recognizes and captures the lid member,
At least a part of the lid member is made of gold,
The structure according to claim 1, wherein the capturing body that specifically recognizes and captures the lid member is a capturing body having an antibody variable region that specifically recognizes and captures gold .
前記蓋部材の少なくとも一部が金で構成され、
前記蓋部材を特異的に認識して捕捉する捕捉体が金を特異的に認識して捕捉する抗体可変領域を有する捕捉体であり、
前記金を特異的に認識して捕捉する抗体可変領域が、配列番号：１〜５７に示されるアミノ酸配列を一つ以上有することを特徴とする請求項１に記載の構造体。 The connection part with the lid member of the connection member includes a capturing body that specifically recognizes and captures the lid member,
At least a part of the lid member is made of gold,
The capture body that specifically recognizes and captures the lid member is a capture body having an antibody variable region that specifically recognizes and captures gold,
The structure according to claim 1, wherein the antibody variable region that specifically recognizes and captures gold has one or more amino acid sequences represented by SEQ ID NOs: 1 to 57 .
前記蓋部材の少なくとも一部が金で構成され、
前記蓋部材を特異的に認識して捕捉する捕捉体が金を特異的に認識して捕捉する抗体可変領域を有する捕捉体であり、
前記金を特異的に認識して捕捉する抗体可変領域が、配列番号：１〜５７に示されるアミノ酸配列のうちの一つの配列の一個もしくは数個のアミノ酸が、欠失、置換もしくは付加されたアミノ酸配列を一つ以上有することを特徴とする請求項１に記載の構造体。 The connection part with the lid member of the connection member includes a capturing body that specifically recognizes and captures the lid member,
At least a part of the lid member is made of gold,
The capture body that specifically recognizes and captures the lid member is a capture body having an antibody variable region that specifically recognizes and captures gold,
In the antibody variable region that specifically recognizes and captures gold, one or several amino acids of one of the amino acid sequences shown in SEQ ID NOs: 1 to 57 are deleted, substituted, or added. The structure according to claim 1, which has one or more amino acid sequences .
前記蓋部材の少なくとも一部が酸化珪素で構成され、 At least a part of the lid member is made of silicon oxide;
前記蓋部材を特異的に認識して捕捉する捕捉体が酸化珪素を特異的に認識して捕捉する抗体可変領域を有する捕捉体であることを特徴とする請求項１に記載の構造体。 The structure according to claim 1, wherein the capturing body that specifically recognizes and captures the lid member is a capturing body having an antibody variable region that specifically recognizes and captures silicon oxide.
前記蓋部材の少なくとも一部が酸化珪素で構成され、
前記蓋部材を特異的に認識して捕捉する捕捉体が酸化珪素を特異的に認識して捕捉する抗体可変領域を有する捕捉体であり、
前記金を特異的に認識して捕捉する抗体可変領域が、配列番号８０に示されるアミノ酸配列を有するもしくは配列番号８１に示されるアミノ酸配列のいずれか一つの配列の一個もしくは数個のアミノ酸が、欠失、置換もしくは付加されたアミノ酸配列を二つ以上有することを特徴とする請求項１に記載の構造体。 The connection part with the lid member of the connection member includes a capturing body that specifically recognizes and captures the lid member,
At least a part of the lid member is made of silicon oxide;
The capture body that specifically recognizes and captures the lid member is a capture body having an antibody variable region that specifically recognizes and captures silicon oxide,
The antibody variable region that specifically recognizes and captures gold has the amino acid sequence represented by SEQ ID NO: 80, or one or several amino acids of any one of the amino acid sequences represented by SEQ ID NO: 81, The structure according to claim 1, which has two or more amino acid sequences deleted, substituted or added .
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2005104831A JP4834321B2 (en) | 2004-03-31 | 2005-03-31 | Structure |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2004108329 | 2004-03-31 | ||
| JP2004108329 | 2004-03-31 | ||
| JP2005104831A JP4834321B2 (en) | 2004-03-31 | 2005-03-31 | Structure |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2005314411A JP2005314411A (en) | 2005-11-10 |
| JP2005314411A5 true JP2005314411A5 (en) | 2008-05-15 |
| JP4834321B2 JP4834321B2 (en) | 2011-12-14 |
Family
ID=35442193
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2005104831A Expired - Fee Related JP4834321B2 (en) | 2004-03-31 | 2005-03-31 | Structure |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JP4834321B2 (en) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP5142177B2 (en) * | 2005-11-28 | 2013-02-13 | Ｔｏｔｏ株式会社 | Materials and methods for controlling agent release |
| US20080187487A1 (en) * | 2006-05-03 | 2008-08-07 | Gustavo Larsen | Methods for producing multilayered particles, fibers and sprays and methods for administering the same |
| WO2008099968A1 (en) | 2007-02-15 | 2008-08-21 | Tohoku University | Zinc oxide-binding antibody and use thereof |
| JP5300205B2 (en) * | 2007-03-22 | 2013-09-25 | キヤノン株式会社 | Target substance detection element, target substance detection method, and method for manufacturing target substance detection element |
| JP5687832B2 (en) * | 2009-12-10 | 2015-03-25 | 花王株式会社 | Composite silica particles |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP4192235B2 (en) * | 2002-04-30 | 2008-12-10 | 独立行政法人産業技術総合研究所 | Mesoporous inorganic material with sustained release function |
| JP2004083501A (en) * | 2002-08-28 | 2004-03-18 | Toyota Central Res & Dev Lab Inc | Stabilized antibody and immunoreaction method and immunoreaction device using the same |
| JP4429105B2 (en) * | 2003-08-19 | 2010-03-10 | キヤノン株式会社 | Organic substance-immobilized structure and production method thereof, peptide and DNA |
| JP4095622B2 (en) * | 2004-03-31 | 2008-06-04 | キヤノン株式会社 | Gold-binding complex protein |
-
2005
- 2005-03-31 JP JP2005104831A patent/JP4834321B2/en not_active Expired - Fee Related
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