JP2005314260A5 - - Google Patents

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Publication number
JP2005314260A5
JP2005314260A5 JP2004132592A JP2004132592A JP2005314260A5 JP 2005314260 A5 JP2005314260 A5 JP 2005314260A5 JP 2004132592 A JP2004132592 A JP 2004132592A JP 2004132592 A JP2004132592 A JP 2004132592A JP 2005314260 A5 JP2005314260 A5 JP 2005314260A5
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JP
Japan
Prior art keywords
dihyrofurano
benzopyran
trihydroxy
μmol
hydroxymethyl
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Pending
Application number
JP2004132592A
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Japanese (ja)
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JP2005314260A (en
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Priority to JP2004132592A priority Critical patent/JP2005314260A/en
Priority claimed from JP2004132592A external-priority patent/JP2005314260A/en
Publication of JP2005314260A publication Critical patent/JP2005314260A/en
Publication of JP2005314260A5 publication Critical patent/JP2005314260A5/ja
Pending legal-status Critical Current

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Description

化合物11（5,8,9-trihydroxy-7-hydroxymethyl-4'- methoxymethoxy [5'',6'':5',4'] dihyrofurano [2',3':7,6]-4H-1-benzopyran-4-one）（3.0 mg, 7μmol）のメタノール (1 mL) 溶液に CF3COOH (0.1 mL)を加え、室温にて30分攪拌後、反応溶液を減圧濃縮した。得られた残渣をシリカゲルカラムクロマトグラフィー（メタノール:クロロホルム、1:5）にて精製し、2.0 mg (18μmol, 69%)のOTAC（5,8,9-trihydroxy-7-hydroxymethyl-4'-hydroxypyrano [5'',6'':5',4'] dihyrofurano [2',3':7,6]-4H-1-benzopyran-4-one)を無色アモルファスとして得た。

Figure 2005314260
Compound 11 (5,8,9-trihydroxy-7-hydroxymethyl-4'-methoxymethoxy [5 '', 6 '': 5 ', 4'] dihyrofurano [2 ', 3': 7,6] -4H-1 -benzopyran-4-one) (3.0 mg, 7 μmol) in methanol (1 mL) was added CF 3 COOH (0.1 mL), stirred at room temperature for 30 minutes, and the reaction solution was concentrated under reduced pressure. The obtained residue was purified by silica gel column chromatography (methanol: chloroform, 1: 5), and 2.0 mg (18 μmol, 69%) of OTAC (5,8,9-trihydroxy-7-hydroxymethyl-4'-hydroxypyrano [5 '', 6 '': 5 ', 4'] dihyrofurano [2 ', 3': 7,6] -4H-1-benzopyran-4-one) was obtained as colorless amorphous.
Figure 2005314260

JP2004132592A 2004-04-28 2004-04-28 Method for producing flavone c glycoside Pending JP2005314260A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2004132592A JP2005314260A (en) 2004-04-28 2004-04-28 Method for producing flavone c glycoside

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP2004132592A JP2005314260A (en) 2004-04-28 2004-04-28 Method for producing flavone c glycoside

Publications (2)

Publication Number Publication Date
JP2005314260A JP2005314260A (en) 2005-11-10
JP2005314260A5 true JP2005314260A5 (en) 2007-07-26

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ID=35442052

Family Applications (1)

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JP2004132592A Pending JP2005314260A (en) 2004-04-28 2004-04-28 Method for producing flavone c glycoside

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Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2008239513A (en) * 2007-03-26 2008-10-09 Shizuokaken Koritsu Daigaku Hojin New method for producing chafuroside based on efficient flavone construction
EP2385049A4 (en) 2009-01-03 2012-08-08 Shizuoka Prefecture Public University Corp Sulfated c-glycoside, method for isolating same and method for synthesizing same
WO2011064726A1 (en) * 2009-11-24 2011-06-03 South African Medical Research Council Method for the synthesis of aspalathin and analogues thereof
CN108440473A (en) * 2018-05-08 2018-08-24 华东师范大学 The preparation method of one kind 2,6- dideoxy naphthols glycoside derivates

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0196106A (en) * 1987-10-09 1989-04-14 Shiseido Co Ltd External drug for skin
US5489697A (en) * 1994-08-03 1996-02-06 Medichem Research, Inc. Method for the preparation of (+)-calanolide A and intermediates thereof
BR0209343A (en) * 2001-04-26 2004-06-15 Wyeth Corp Azaheterocyclylmethyl antidepressants derived from oxaheterocyclo [1,4] -benzodioxanes; methods of treatment using such compounds; process to prepare them
JP3829273B2 (en) * 2001-05-08 2006-10-04 学校法人日本大学 Process for producing optically active flavanones and chromanones
JP4549009B2 (en) * 2002-07-03 2010-09-22 サントリーホールディングス株式会社 Novel derivative of flavone C-glycoside and composition containing the same
JP2006176407A (en) * 2003-04-18 2006-07-06 Daiichi Asubio Pharma Co Ltd New flavone derivative, method for producing the same and medicine composition containing the same
JP2005289888A (en) * 2004-03-31 2005-10-20 Suntory Ltd Preparation method of flavone c glycoside derivative

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