JP2005289876A - Antibacterial agent derived from crude drug and composition for external use comprising the same - Google Patents
Antibacterial agent derived from crude drug and composition for external use comprising the same Download PDFInfo
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- JP2005289876A JP2005289876A JP2004106920A JP2004106920A JP2005289876A JP 2005289876 A JP2005289876 A JP 2005289876A JP 2004106920 A JP2004106920 A JP 2004106920A JP 2004106920 A JP2004106920 A JP 2004106920A JP 2005289876 A JP2005289876 A JP 2005289876A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/04—Antipruritics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/10—Anti-acne agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/005—Antimicrobial preparations
Abstract
Description
本発明は、モッコウエキスを有効成分とする抗菌剤及びこれを含有する外用組成物に関する。 The present invention relates to an antibacterial agent containing mokko extract as an active ingredient and an external composition containing the same.
ニキビ(尋常性ざ瘡)は、皮膚の毛嚢脂腺系を中心とした毛孔におこる表在性の慢性炎症状態を指し、思春期の男女に多く見られる。ニキビの原因は、まだ不明な点が多いが、その原因の1つとして、皮膚に常在するプロピオニバクテリウム アクネス(Propionibacterium acnes)が関与していると考えられている。 Acne (acne vulgaris) is a superficial chronic inflammatory condition that occurs in the pores of the skin, the follicular sebaceous glands, and is common in adolescent men and women. The cause of acne is still unclear, but one of the causes is considered to be related to Propionibacterium acnes, which are resident in the skin.
プロピオニバクテリウム アクネスは、皮膚の毛孔内に存在し、脂質(皮脂)を分解して遊離脂肪酸を生成する。この遊離脂肪酸には、面皰形成作用、炎症惹起作用があることが知られている。思春期に性ホルモン等の影響によって皮脂分泌が活発になると、遊離脂肪酸が過剰に生成され、その結果ニキビを発症するとされている。 Propionibacterium acnes is present in the pores of the skin and breaks down lipids (sebum) to produce free fatty acids. This free fatty acid is known to have comedone-forming action and inflammation-inducing action. When sebum secretion becomes active due to the effects of sex hormones during puberty, excessive free fatty acids are produced, resulting in acne.
従来、ニキビ治療剤として、プロピオニバクテリウム アクネスに対する抗菌作用をはじめ、皮脂分泌抑制作用、角質溶解作用を有するものが広く用いられてきた。 Conventionally, as an acne treatment agent, an antibacterial action against Propionibacterium acnes, a sebum secretion inhibitory action, and a keratolytic action have been widely used.
しかしながら、これら既存のニキビ治療剤には、種々の副作用を伴う。例えば、皮脂分泌抑制作用を有する女性ホルモン剤、及び抗菌作用を有するエリスロマイシン、テトラサイクリン等の抗生物質等は、胃腸障害を引き起こすことが知られている(非特許文献1)。また、角質溶解作用を有するイオウ、カンフル、サルファ剤等は、度重なる塗布による患部周辺の皮膚に対する刺激が強く、かさつき等が問題となっている。 However, these existing acne treatment agents have various side effects. For example, it is known that a female hormone agent having a sebum secretion inhibitory action and antibiotics such as erythromycin and tetracycline having an antibacterial action cause gastrointestinal disorders (Non-patent Document 1). In addition, sulfur, camphor, sulfa drugs and the like having a keratolytic action have a strong irritation to the skin around the affected area due to repeated application, and there is a problem of roughness.
なお、上記の他に、ゲレップ、蘇方木、矢車の実、ログウッド等から得られた植物エキスを有効成分とするニキビ治療剤も知られている(例えば、特許文献1参照)。
本発明は、ニキビの原因菌であるプロピオニバクテリウム アクネスに対して高い抗菌作用を有し、皮膚刺激等の副作用の少ない安全性に優れた抗菌剤及びこれを含有する外用組成物を提供することを主な目的とする。 The present invention provides an antibacterial agent having a high antibacterial action against propionibacteria acnes, which is a causative agent of acne, and having excellent side effects such as skin irritation and an external composition containing the same. The main purpose.
本発明者らは、モッコウエキスがプロピオニバクテリウム アクネスに対して高い抗菌作用を有することを見出し、本発明を完成するに至った。 The inventors of the present invention have found that the mokko extract has a high antibacterial action against Propionibacterium acnes, and have completed the present invention.
本発明は、以下の抗菌剤及びこれを含有する外用組成物を提供する。
項1.モッコウエキスを有効成分とするプロピオニバクテリウム アクネスに対する抗菌剤。
項2.項1に記載の抗菌剤を含む外用組成物。
項3.抗ニキビ用である項2に記載の外用組成物。
The present invention provides the following antibacterial agents and external compositions containing the same.
Item 1. Antibacterial agent against Propionibacterium acnes containing mokko extract as an active ingredient.
Item 2. Item 3. An external composition comprising the antibacterial agent according to Item 1.
Item 3. Item 3. The composition for external use according to Item 2, which is used for anti-acne.
本発明の抗菌剤の有効成分であるモッコウエキスは、モッコウ(木香)と呼ばれるキク科の大形多年草から得られる。モッコウエキスとしては、モッコウの根から得られるものが好ましいが、プロピオニバクテリウム アクネスに対する抗菌効果が得られるものであれば、モッコウの植物体全体(全草)又は根以外の任意の部分(例えば、葉、根茎、茎、根皮等)から抽出されたものを用いてもよい。 The mokko extract, which is an active ingredient of the antibacterial agent of the present invention, is obtained from a large perennial plant belonging to the family Asteraceae called mokko. As the mokko extract, those obtained from the root of mokko are preferred, but as long as the antibacterial effect against Propionibacterium acnes can be obtained, the entire mokko plant (whole plant) or any part other than the root (for example, , Leaves, rhizomes, stems, root barks, etc.) may be used.
本発明で用いるモッコウエキスの製造方法としては、従来公知の方法を使用することができ、例えば、モッコウ又はモッコウの乾燥物を水又は熱水抽出、あるいは有機溶媒で抽出し、濾過する方法等があげられる。抽出の条件としては、一般的に植物抽出に用いられるものであれば特に限定されない。さらに、抽出、濾過の後、必要に応じて該エキスを濃縮してもよい。濃縮の方法としては、エバポレーター等の常法を用いることができる。また、市販のモッコウエキスを用いてもよい。 As a method for producing the mokko extract used in the present invention, a conventionally known method can be used, for example, a method of extracting mokko or dried mokko with water or hot water, or extracting with an organic solvent and filtering. can give. The extraction conditions are not particularly limited as long as they are generally used for plant extraction. Further, after extraction and filtration, the extract may be concentrated as necessary. As a concentration method, a conventional method such as an evaporator can be used. Moreover, you may use a commercially available mokko extract.
抽出に用いる溶媒としては、公知のものを用いればよく、例えば、水、メタノール、エタノール、プロパノール、イソプロパノール、ブタノール、エチレングリコール、プロピレングリコール、1,3−ブチレングリコール、ジエチレングリコール、ジプロピレングリコール、イソプレングリコール、へキシレングリコール、グリセリン、酢酸メチル、酢酸エチル、酢酸イソプロピル、エチルエーテル、イソプロピルエーテル、アセトン等の有機溶媒を用いることができ、水、エタノールが好ましい。これらの抽出溶媒から、1種を単独で、又は2種以上を混合して使用する。 As a solvent used for extraction, a known solvent may be used, for example, water, methanol, ethanol, propanol, isopropanol, butanol, ethylene glycol, propylene glycol, 1,3-butylene glycol, diethylene glycol, dipropylene glycol, isoprene glycol. Organic solvents such as hexylene glycol, glycerin, methyl acetate, ethyl acetate, isopropyl acetate, ethyl ether, isopropyl ether, and acetone can be used, and water and ethanol are preferred. From these extraction solvents, one kind is used alone, or two or more kinds are used in combination.
この様にして得られた抽出物は、本発明の抗菌剤としてそのまま用いることもできるし、また、本発明の効果を失わない範囲内で脱臭、脱色等の精製操作を加えることもできる。さらに、本発明の抗菌剤は、上記の抽出物から抽出溶媒を蒸発、乾固させて粉末状で用いることもでき、又は水、エタノール、プロピレングリコール、1,3−ブチレングリコール、グリセリン等の溶媒に再溶解して用いることもできる。 The extract thus obtained can be used as it is as the antibacterial agent of the present invention, and purification operations such as deodorization and decolorization can be added within a range not losing the effects of the present invention. Furthermore, the antibacterial agent of the present invention can be used in the form of powder by evaporating and drying the extraction solvent from the above extract, or a solvent such as water, ethanol, propylene glycol, 1,3-butylene glycol, glycerin, etc. It can also be redissolved and used.
本発明の抗菌剤は、上記抽出物又はその組成物からなるものであってもよいが、さらに賦形剤、担体、防腐剤、抗酸化剤、安定化剤等を含んでいてもよい。また、他の抗菌剤を含んでいてもよい。 The antibacterial agent of the present invention may be composed of the above extract or a composition thereof, but may further contain excipients, carriers, preservatives, antioxidants, stabilizers and the like. Moreover, the other antibacterial agent may be included.
本発明の抗菌剤は、後述する実施例1で示すように、特にプロピオニバクテリウム アクネス(Propionibacterium acnes)に対して良好な抗菌活性を有している。その有効量は、モッコウエキスとして、該エキス1gあたり、局方記載の「モッコウ」の乾燥重量4gから抽出される量の抽出成分を含むものを使用する場合であれば、本発明の抗菌剤におけるモッコウエキスの有効量は、該剤の総量に対して、例えば1重量%程度以上、好ましくは5重量%程度以上、更に好ましくは10重量%程度以上が例示される。 The antibacterial agent of the present invention has a good antibacterial activity particularly against Propionibacterium acnes, as shown in Example 1 described later. The effective amount of the antibacterial agent of the present invention is that the extract contains an extract component in an amount extracted from 4 g of the dry weight of “Mokkou” described in the pharmacopoeia per 1 g of the extract. The effective amount of the mokko extract is, for example, about 1% by weight or more, preferably about 5% by weight or more, and more preferably about 10% by weight or more with respect to the total amount of the agent.
また、本発明の抗菌剤100g中に、乾燥重量4g程度以上の局方記載の「モッコウ」から水又はエタノールで抽出される量の抽出成分を含んでいることが望ましく、好ましくは20g程度以上、さらに好ましくは40g程度以上の「モッコウ」から得られる該抽出成分を含むことが望ましい。 Moreover, it is desirable that 100 g of the antibacterial agent of the present invention contains an extraction component in an amount extracted from water or ethanol from “Mokkou” described in the Japanese Pharmacopoeia having a dry weight of about 4 g or more, preferably about 20 g or more More preferably, it contains about 40 g or more of the extract component obtained from “mokko”.
ゆえに、本発明の抗菌剤は、例えば、抗ニキビを目的とする外用組成物の抗菌成分として有効に用いることができる。また、本発明の抗菌剤に、他の抗菌剤及び抗菌作用を有する化合物(エタノール等)を加える場合は、上記よりも少ない量で抗菌効果を得ることができる。よって、該有効量の範囲は、モッコウエキスとして1重量%程度以上に限定されない。 Therefore, the antibacterial agent of the present invention can be effectively used, for example, as an antibacterial component of an external composition intended for anti-acne. Moreover, when adding another antibacterial agent and the compound (ethanol etc.) which has an antibacterial action to the antibacterial agent of this invention, an antibacterial effect can be acquired in less quantity than the above. Therefore, the range of the effective amount is not limited to about 1% by weight or more as the mokko extract.
従って、本発明は、さらに、上記の抗菌剤を含有する外用組成物、特に抗ニキビ用の外用組成物を提供する。なお、本発明において抗ニキビとは、ニキビの予防及び/又は治療を目的として用いることを指す。 Accordingly, the present invention further provides an external composition containing the above antibacterial agent, particularly an anti-acne external composition. In the present invention, anti-acne refers to use for the purpose of preventing and / or treating acne.
本発明の外用組成物は、上記本発明の抗菌剤を1成分として、製造過程の任意の段階で配合することによって調製することができる。本発明の抗菌剤を含有する外用組成物の剤型は、該抗菌剤の効果が得られるものであれば特に限定されず、例えば、軟膏、液剤、クリーム、貼付剤、パップ剤、ローション剤、エアゾール剤、石鹸、浴用剤、洗浄剤、パック剤、化粧水、乳液、スキンコンディショナー、クリーム、下地化粧料、ファンデーション、コンシーラー等の医薬品、医薬部外品、化粧料等に広く使用され得る。 The composition for external use of the present invention can be prepared by blending the antibacterial agent of the present invention as one component at any stage of the production process. The dosage form of the composition for external use containing the antibacterial agent of the present invention is not particularly limited as long as the effect of the antibacterial agent can be obtained. For example, ointments, liquids, creams, patches, poultices, lotions, It can be widely used for aerosols, soaps, bathing agents, cleaning agents, packs, lotions, emulsions, skin conditioners, creams, base cosmetics, foundations, concealers and other pharmaceuticals, quasi drugs, cosmetics and the like.
特に、本発明の外用組成物の有効成分であるモッコウエキスは、ニキビの原因菌であるプロピオニバクテリウム アクネスに対する抗菌作用を有することから、抗ニキビ組成物として使用することができる。 In particular, the mokko extract, which is an active ingredient of the composition for external use of the present invention, can be used as an anti-acne composition because it has an antibacterial action against Propionibacterium acnes, the causative agent of acne.
モッコウエキスとして、該エキス1gあたり、局方記載の「モッコウ」の乾燥重量4gから抽出される量の抽出成分を含むものを使用する場合であれば、本発明の抗菌剤におけるモッコウエキスの有効量は、該剤の総量に対して、例えば0.5〜100重量%程度以上、好ましくは1〜100重量%程度以上、さらに好ましくは10〜100重量%程度以上が例示される。 When using an extract containing an extraction component in an amount extracted from 4 g of the dry weight of “Mokkou” described in the pharmacopoeia per 1 g of the extract, the effective amount of the Moko extract in the antibacterial agent of the present invention Is, for example, about 0.5 to 100% by weight or more, preferably about 1 to 100% by weight or more, and more preferably about 10 to 100% by weight or more with respect to the total amount of the agent.
また、例えば、本発明の抗菌剤100g中に、乾燥重量2〜400g程度の局方記載の「モッコウ」から水又はエタノールで抽出される量の抽出成分を含んでいることが望ましく、好ましくは4〜400g程度、より好ましくは40〜400g程度の「モッコウ」から得られる該抽出成分を含むことが望ましい。 In addition, for example, it is desirable that 100 g of the antibacterial agent of the present invention contains an extraction component in an amount extracted with water or ethanol from “Mokkou” described in the Japanese Pharmacopoeia having a dry weight of about 2 to 400 g, preferably 4 It is desirable to include the extracted component obtained from about ˜400 g, more preferably about 40 to 400 g of “mokko”.
抗ニキビ組成物以外の外用組成物として本発明の抗菌剤を用いる場合には、当業者であれば、上記の例を参考に容易に配合量等を決定することができる。 When using the antibacterial agent of the present invention as an external composition other than the anti-acne composition, those skilled in the art can easily determine the blending amount and the like with reference to the above example.
また、本発明の組成物には、必要に応じて、化粧料、医薬部外品、医薬品に一般的に用いられる各種成分、水性成分、油性成分、保湿成分、賦形剤、増粘剤、防腐剤、酸化防止剤、pH調整剤、担体、香料、色剤、薬剤等を単独又は2種以上を混合して用いてもよい。 In addition, the composition of the present invention includes, as necessary, various components commonly used in cosmetics, quasi-drugs, pharmaceuticals, aqueous components, oily components, moisturizing components, excipients, thickeners, You may use antiseptic | preservative, antioxidant, pH adjuster, a carrier, a fragrance | flavor, a coloring agent, a chemical | medical agent, etc. individually or in mixture of 2 or more types.
本発明の外用組成物として、本発明の効果を損なわない範囲内で、公知の抗菌剤、角質軟化剤及び消炎剤を含んでもよい。 The composition for external use of the present invention may contain a known antibacterial agent, keratin softener and anti-inflammatory agent as long as the effects of the present invention are not impaired.
抗菌剤としては、イオウ、ヒノキチオール、トリクロサン、トリクロロカルバニリド、ハロカルパン、クロロフェネシン、塩化ベンゼトニウム、塩化ベンザルコニウム、塩酸アルキルジアミノエチルグリシン、塩酸クロルヘキシジン、グルコン酸クロルヘキシジン、イソプロピルメチルフェノール、安息香酸、チモール、ヘキサクロロフェン、ベルベリン、レゾルシン、塩化セチルピリジニウム及びこれらの誘導体等があげられる。 Antibacterial agents include sulfur, hinokitiol, triclosan, trichlorocarbanilide, halocarpan, chlorophenesin, benzethonium chloride, benzalkonium chloride, alkyldiaminoethylglycine hydrochloride, chlorhexidine hydrochloride, chlorhexidine gluconate, isopropylmethylphenol, benzoic acid, Examples include thymol, hexachlorophene, berberine, resorcin, cetylpyridinium chloride, and derivatives thereof.
角質軟化剤としては、イオウ、サリチル酸、レゾルシン、尿素等があげられる。 Examples of the keratin softener include sulfur, salicylic acid, resorcin, and urea.
消炎剤としては、ケトプロフェン、イブプロフェンピコノール、グリチルレチン酸、グリチルリチン酸ジカリウム、グリチルリチン酸、インドメタシン、ジクロフェナック、ピロキシカム、プラノプロフェン、フルルビプロフェン、ロキソプロフェン、酢酸コルチゾン、ヒドロコルチゾン、デキサメタゾン、プレドニゾロン、ベタメタゾン、フェルビナク等があげられる。 Anti-inflammatory agents include ketoprofen, ibuprofen piconol, glycyrrhetinic acid, dipotassium glycyrrhizinate, glycyrrhizic acid, indomethacin, diclofenac, piroxicam, pranoprofen, flurbiprofen, loxoprofen, cortisone acetate, hydrocortisone, dexamethasone, prednisolone, betamethasone, betamethasone Etc.
上記の抗菌剤、角質軟化剤及び消炎剤を用いる場合、単独で使用してもよく、2種以上を組み合わせて使用してもよい。本発明の抗菌剤と併用することにより、その良好な抗菌活性に基づいて、副作用が問題となっている既知の殺菌剤、角質軟化剤、消炎剤の量を減じることも可能であり、外用組成物としての安全性を高めることが期待される。 When using the above antibacterial agent, keratin softener and anti-inflammatory agent, they may be used alone or in combination of two or more. By using in combination with the antibacterial agent of the present invention, it is possible to reduce the amount of known bactericides, keratin softeners, anti-inflammatory agents, which cause side effects, based on their good antibacterial activity. It is expected to increase safety as a product.
本発明によれば、ニキビの原因菌であるプロピオニバクテリウム アクネスに対して高い抗菌作用を有し、かつ生薬成分であるモッコウ抽出物を有効成分とすることから安全性の高い抗菌剤を提供することができる。また、該抗菌剤を含有する外用組成物、特に抗ニキビ用外用組成物を提供することができる。 According to the present invention, a highly safe antibacterial agent is provided because it has a high antibacterial action against propionibacteria acnes, which is a causative agent of acne, and uses a mokko extract, which is a herbal medicine component, as an active ingredient. can do. Moreover, the composition for external use containing this antibacterial agent, especially the composition for external use for anti-acne can be provided.
以下、実施例をあげて本発明を具体的に説明するが、本発明はこれらの実施例に何ら限定されるものではない。 EXAMPLES Hereinafter, the present invention will be specifically described with reference to examples, but the present invention is not limited to these examples.
試験方法
ペーパーディスク法による阻止円径の測定により抗菌力を評価した。
Test method Antibacterial activity was evaluated by measuring the inhibition circle diameter by the paper disk method.
プロピオニバクテリウム アクネスを、GAM寒天培地に塗布し、35℃にて24時間、嫌気培養を行い、増菌させた後、減菌生理食塩水にMacfaland0.5になるように懸濁させた。 Propionibacterium acnes was applied to a GAM agar medium, subjected to anaerobic culture at 35 ° C. for 24 hours to increase the number of bacteria, and then suspended in sterilized physiological saline to give Macfarand 0.5.
シャーレ中のGAM寒天培地上に、この懸濁液0.05mlをコンラージ棒で均一に塗布し、その上にペーパーディスク(直径8mm)を置いて試料(モッコウエキス又はオウゴンエキス)0.1mlを含浸させた。これを35℃にて48時間嫌気培養後、阻止円の有無とその直径を測定した。比較例として、プロピオニバクテリウム アクネスに対する抗菌効果が公知である、オウゴンエキスを使用した。 On a GAM agar medium in a petri dish, 0.05 ml of this suspension is evenly applied with a congeal rod, and a paper disk (diameter 8 mm) is placed on it and impregnated with 0.1 ml of a sample (Mokkou extract or Ogon extract). I let you. After anaerobic culture at 35 ° C. for 48 hours, the presence or absence of a blocking circle and its diameter were measured. As a comparative example, an Augon extract, which has a known antibacterial effect against Propionibacterium acnes, was used.
試験結果
モッコウエキスは、オウゴンエキスと比較して同等以上の阻止円径を示し、プロピオニバクテリウム アクネスに対する抗菌剤として有用であることがわかった。
Test results The mokko extract showed an inhibition diameter equal to or greater than that of the ogon extract, and was found to be useful as an antibacterial agent against Propionibacterium acnes.
ペーパーディスク法による測定結果を表1に示す。 The measurement results by the paper disk method are shown in Table 1.
以下、モッコウエキスを用いた製剤の処方例を示すが、本発明はこれに限定されるものではない。 Hereinafter, although the formulation example of the formulation using a mokko extract is shown, this invention is not limited to this.
[処方例1]
軟膏 [g]
モッコウエキス 10
グリチルリチン酸ジカリウム0.5
ベントナイト 20
カオリン 20
グリセリン 10
プロピレングリコール 5
精製水 34.5
──────────────────
合計 100
[Prescription Example 1]
Ointment [g]
Mokko extract 10
Dipotassium glycyrrhizinate 0.5
Bentonite 20
Kaolin 20
Glycerin 10
Propylene glycol 5
Purified water 34.5
──────────────────
Total 100
[処方例2]
軟膏 [g]
モッコウエキス 10
イオウ 2
グリチルリチン酸ジカリウム 0.5
ベントナイト 20
カオリン 20
グリセリン 10
プロピレングリコール 5
精製水 32.5
───────────────────
合計 100
[Prescription Example 2]
Ointment [g]
Mokko extract 10
Sulfur 2
Dipotassium glycyrrhizinate 0.5
Bentonite 20
Kaolin 20
Glycerin 10
Propylene glycol 5
Purified water 32.5
───────────────────
Total 100
[処方例3]
液剤 [g]
モッコウエキス 10
ポリオキシエチレンオレイルエーテル1
エタノール 10
パラベン 0.1
精製水 78.9
──────────────────────
合計 100
[Prescription Example 3]
Liquid [g]
Mokko extract 10
Polyoxyethylene oleyl ether 1
Ethanol 10
Paraben 0.1
Purified water 78.9
──────────────────────
Total 100
[処方例4]
エアゾール [g]
モッコウエキス 5
イソプロピルメチルフェノール 0.1
エタノール 20
精製水 24.9
液化石油ガス 50
─────────────────────
合計 100
[Prescription Example 4]
Aerosol [g]
Mokko extract 5
Isopropylmethylphenol 0.1
Ethanol 20
Purified water 24.9
Liquefied petroleum gas 50
─────────────────────
Total 100
Claims (3)
The composition for external use according to claim 2, which is used for anti-acne.
Priority Applications (2)
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JP2004106920A JP4666937B2 (en) | 2004-03-31 | 2004-03-31 | Antibacterial agent derived from herbal medicine and composition for external use containing the same |
PCT/JP2004/013360 WO2005099731A1 (en) | 2004-03-31 | 2004-09-14 | Antibacterial agent derived from galenical and composition for external application containing the same |
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JP2004106920A JP4666937B2 (en) | 2004-03-31 | 2004-03-31 | Antibacterial agent derived from herbal medicine and composition for external use containing the same |
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JP2007119432A (en) * | 2005-10-31 | 2007-05-17 | Ichimaru Pharcos Co Ltd | Activator of peroxisome proliferator-activated receptor (ppar) |
Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH06227960A (en) * | 1993-02-01 | 1994-08-16 | Yakult Honsha Co Ltd | Melanin formation inhibitor and skin cosmetic |
JP2000136141A (en) * | 1998-10-30 | 2000-05-16 | Sumitomo Forestry Co Ltd | Antibacterial agent |
JP2001322940A (en) * | 2000-05-12 | 2001-11-20 | Kao Corp | Cathepsin d production facilitative agent |
JP2003335696A (en) * | 2002-05-14 | 2003-11-25 | Jakwang Co Ltd | Natural cell transmitter comprising water soluble chitosan and extract of inula helenium l. |
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2004
- 2004-03-31 JP JP2004106920A patent/JP4666937B2/en not_active Expired - Fee Related
- 2004-09-14 WO PCT/JP2004/013360 patent/WO2005099731A1/en active Application Filing
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH06227960A (en) * | 1993-02-01 | 1994-08-16 | Yakult Honsha Co Ltd | Melanin formation inhibitor and skin cosmetic |
JP2000136141A (en) * | 1998-10-30 | 2000-05-16 | Sumitomo Forestry Co Ltd | Antibacterial agent |
JP2001322940A (en) * | 2000-05-12 | 2001-11-20 | Kao Corp | Cathepsin d production facilitative agent |
JP2003335696A (en) * | 2002-05-14 | 2003-11-25 | Jakwang Co Ltd | Natural cell transmitter comprising water soluble chitosan and extract of inula helenium l. |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2007119432A (en) * | 2005-10-31 | 2007-05-17 | Ichimaru Pharcos Co Ltd | Activator of peroxisome proliferator-activated receptor (ppar) |
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