JP2005270289A - Hollow fiber type blood purification device - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To prevent the thrombogenesis by eliminating stagnation of the blood in a blood supply space. <P>SOLUTION: Both ends of a hollow fiber bundle 3 are potted inside a case 2 so that the inside of the case is partitioned into a blood channel inside the hollow fibers and a process liquid channel outside the hollow fibers, and cap members 7 and 9 are liquid-tightly attached to the both ends of the case. The cap members 7 and 9 are provided with a blood inlet port 6 and a blood outlet port 8 communicating with the blood channel. The case is provided with a process liquid inlet port 13 and a process liquid outlet port 14 communicating with the process liquid channel. The blood supply spaces 24 where the blood introduced from the blood inlet port 6 is passed before flows in the blood channel are formed between the end faces of the hollow fiber bundle 3 and the ceiling surfaces of the cap members 7 and 9. The ceiling surfaces of the cap members 7 and 9 are formed with resistance parts 32 protruded toward the end face sides of the hollow fiber bundle 3 and provided with blood inlet ports 20 facing outward the outer edge parts of the resistance parts 32 out of the blood supply spaces 24. <P>COPYRIGHT: (C)2006,JPO&NCIPI

Description

  The present invention relates to a blood purifier used for blood purification therapy such as dialysis treatment, and more particularly to one using a semipermeable hollow fiber.

  The hollow fiber blood purifier is used for purifying blood of a patient having a disease in the kidney or liver, for example. In this blood purifier, a hollow fiber bundle is loaded into a cylindrical case, and the inside of the case is partitioned into a blood channel inside the hollow fiber and a treatment liquid channel outside the hollow fiber. Then, substance exchange is performed between the blood flowing through the blood channel and the processing liquid flowing through the processing liquid channel via the hollow fiber. That is, excess components in the blood are moved from the blood to the treatment liquid, while insufficient components in the blood are replenished from the treatment liquid to the blood. In this blood purifier, a blood supply space is formed between the blood introduction port and the end face of the hollow fiber bundle. Therefore, the blood introduced from the blood introduction port flows through the blood flow path inside the hollow fiber after once passing through this blood supply space. This blood supply space is formed as an inner space of a cap member attached to the case end. Some of the cap members are formed in a substantially funnel shape (see, for example, Patent Document 1). In this cap member, the tube tip portion functions as a blood introduction port. In addition to the blood introduction port, a cap member is also proposed in which a treatment liquid outlet port for leading (discharge) the treatment liquid is integrally provided (see, for example, Patent Document 2). Further, there is a configuration in which a blood introduction port is provided on the side surface of the cap member so that blood can be introduced from the side of the cap member (see, for example, Patent Document 3).

  And, in the cap member formed in a substantially funnel shape and the cap member integrally provided with the treatment liquid outlet port, the inner space of the blood introduction port, that is, the state where the outlet of the blood introduction path faces the substantial center of the end face of the hollow fiber bundle It was established in. In this configuration, the introduced blood is intensively supplied to the central portion of the hollow fiber bundle end face. Further, in the cap member having the blood introduction port protruding from the side surface, the outlet of the blood introduction path in the blood introduction port is opened on the side surface of the blood supply space. In this configuration, since the introduced blood flows in from a direction substantially orthogonal to the longitudinal direction of the hollow fiber, the blood is concentrated around the outlet of the blood introduction path (that is, the blood outlet established inside the cap member). Will be supplied.

Japanese Patent Laid-Open No. 10-305218 (FIG. 1) JP 2000-189762 A (page 5, FIG. 1) Japanese Utility Model Publication No. 6-63048 (FIG. 9)

  By the way, with the cap member having the above-described configuration, blood may be intensively supplied to a part of the blood supply space, and there is a possibility that a thrombus may be generated in a space where the supply amount of blood is smaller than other parts. That is, if there is a portion where the amount of blood supply is small and the blood flow is slow in the blood supply space, proteins in the blood or the like are likely to adhere to the wall surface that divides this space, which may cause thrombus formation. From the viewpoint of preventing the thrombus, it is required to actively increase the flow velocity outside the wall surface to prevent blood from staying in the blood supply space in the cap member. Moreover, in order to efficiently exchange substances between blood and the treatment liquid, it is desirable to supply blood evenly to the hollow fibers constituting the hollow fiber bundle. However, in the cap member configured as described above, blood may be concentratedly supplied to the hollow fiber in a part, and there is room for improvement in this respect.

  The present invention has been made in view of such circumstances, and an object of the present invention is to provide a hollow fiber blood purifier that can prevent blood clot formation by eliminating the retention of blood in the blood supply space. In addition, the present invention can supply blood more evenly to each hollow fiber constituting the hollow fiber bundle, and can further increase the material exchange efficiency between blood and treatment liquid. The purpose is to provide a vessel.

In order to achieve the above object, according to the first aspect of the present invention, a hollow fiber bundle of semipermeable hollow fibers is loaded in a cylindrical case, and both end portions of the hollow fiber bundle are potted on the inner surface of the case. The inside of the case is partitioned into a blood flow path inside the hollow fiber and a treatment liquid flow path outside the hollow fiber, and cap members are attached to both ends of the case in a liquid-tight manner, and the blood communicates with the blood flow path In addition to the introduction port and a treatment liquid port communicating with the treatment liquid channel, the blood introduced from the blood introduction port is inserted into the blood channel between the end surface of the hollow fiber bundle and the ceiling surface of the cap member. In a hollow fiber type blood purifier that forms a blood supply space that flows before flowing in,
Forming a resistance part bulging toward the end face side of the hollow fiber bundle on the ceiling surface of the cap member, and providing a blood introduction port outside the outer edge of the resistance part in the blood supply space; This is a hollow fiber blood purifier.

  The invention according to claim 2 is characterized in that the resistance portion is disposed at a central portion of the ceiling surface, and the interval between the ceiling surface outside the resistance portion and the end surface of the hollow fiber bundle is defined as the interval between the resistance portion and the end surface of the hollow fiber bundle. 2. The hollow fiber blood purifier according to claim 1, wherein the blood introduction port is provided to be set to be larger than the region having a large interval.

  The invention according to claim 3 is the hollow fiber blood purifier according to claim 1, wherein the resistance portion is arranged eccentrically from the center of the ceiling surface.

  The invention according to claim 4 is characterized in that the blood introduction port is provided in an eccentric state from the center of the blood supply space so that the blood introduced into the blood supply space becomes a vortex. To 4. The hollow fiber blood purifier according to any one of items 1 to 3.

  According to the invention according to claim 1, by providing the resistance portion, the blood supply space has a height of the outer region located outside the resistance portion (that is, the distance to the end surface of the hollow fiber bundle). It becomes higher than the height of the opposing area | region which opposes. For this reason, the channel resistance in the outer region is smaller than the channel resistance in the opposing region. Here, since the blood introduction port is provided outward from the outer edge portion of the resistance portion in the blood supply space, blood passing through the blood introduction path is efficiently introduced into the outer region. The blood introduced into the outer region flows so as to surround the resistance portion along the outer region. By this flow, blood can be spread evenly over the entire area of the end face of the hollow fiber bundle. As a result, blood can actively flow toward the outer region, and the flow rate of blood flowing through the outer region can be increased. Thereby, it is possible to prevent blood from staying in the blood supply space. Therefore, it is difficult for proteins in the blood to adhere to the wall surface of the blood supply space, and thrombus formation can be prevented. Furthermore, blood can be supplied more evenly to each hollow fiber, and the mass exchange efficiency between the blood and the treatment liquid can be further increased.

  According to the invention which concerns on Claim 2, a resistance part is arrange | positioned in the center part of a ceiling surface, and the space | interval of the ceiling surface of the outer side of a resistance part and the end surface of a hollow fiber bundle is made into the resistance part and the end surface of a hollow fiber bundle. Since it is set larger than the interval, the blood supply space has the lowest height at the center portion of the end face of the hollow fiber bundle, and the height increases from this position toward the outside. For this reason, the center of the blood flow in the outer region can be aligned with the center of the end face of the hollow fiber bundle, and the blood can be reliably distributed over the entire end face of the hollow fiber bundle. Thereby, blood can be more reliably supplied to each hollow fiber.

  According to the invention which concerns on Claim 3, the flow of blood can be adjusted by arrange | positioning a resistance part eccentrically from the center of a ceiling surface. Thereby, the non-uniform flow of blood caused by insufficient flow rate or the like can be made uniform.

  According to the invention of claim 4, since the blood introduction port is provided in a state eccentric from the center of the blood supply space so that the blood introduced into the blood supply space becomes a vortex, the blood is hollowed out by the vortex. The entire area of the yarn bundle end face can be reliably distributed, and blood can be supplied more evenly to each hollow fiber. Furthermore, since the flow velocity of blood flowing near the wall surface of the blood supply space can be further increased, thrombus formation in the blood supply space can be more reliably prevented.

  Hereinafter, embodiments of the present invention will be described with reference to the drawings. FIG. 1 is a partial cross-sectional view showing a dialyzer which is one embodiment of blood purifier 1 according to the present invention.

  The blood purifier 1 illustrated in FIG. 1 has an introduction-side cap member having a hollow fiber bundle 3 loaded inside a cylindrical case 2 and a blood introduction port 6 for introducing blood at one end of the case 2. 7 is screwed and attached to the other end, and a lead-out cap member 9 having a blood outlet port 8 through which the processed blood flows out is screwed and attached to both ends of the case 2 and the hollow fiber bundle 3 Potting portions 10 that are bonded and fixed with a resin composition such as polyurethane resin are provided and sealed, and a blood flow path (inner space of each hollow fiber membrane) through which blood passes through the space in the case 2 and a treatment liquid Is partitioned into a processing liquid flow path (outside space of each hollow fiber membrane). Further, a treatment liquid (for example, dialysate) introduction port 13 and a discharge port 14 for purification treatment are provided at both ends of the outer periphery of the case 2, and blood supplied from the blood introduction port 6 is treated via the hollow fiber membrane 11. Purification is performed with a treatment liquid such as dialysate injected from the introduction port 13. The processing liquid introduction port 13 and the processing liquid outlet port 14 correspond to the processing liquid port in the present invention, respectively.

  The case 2 has a substantially cylindrical body, and is integrally molded with the processing liquid introduction port 13 and the processing liquid outlet port 14 from a synthetic resin material such as polycarbonate or olefin resin (for example, polypropylene), and is hollow. It is formed as a transparent container so that the status of the yarn bundle 3 can be easily grasped.

  The hollow fiber bundle 3 is a bundle of a large number of hollow fiber membranes 11, and examples of the hollow fiber membrane 11 include cellulose acetate, copper ammonia cellulose, polyacrylonitrile, polymethyl methacrylate, polyethylene, polyvinyl alcohol, polysulfone, polyamide, and polyester polymer. A hollow fiber of an appropriate material such as an alloy, a cellulosic hollow fiber or a synthetic polymer hollow fiber can be used. And each hollow fiber membrane 11 is opened in the outer surface of the potting part 10, without sealing the opening end of a hollow hole.

  The introduction-side cap member 7 and the outlet-side cap member 9 are lid-like members that are screwed and attached so as to close the opening portions at both ends of the case 2. For example, polycarbonate, olefin resin (for example, polypropylene), etc. Molded with synthetic resin material. A female screw portion 21 is formed on the inner peripheral surfaces of the cap members 7 and 9. The female screw portions 21 of the cap members 7 and 9 are for screwing and mounting to the male screw portions 22 formed on the cap mounting portions 20 at both ends of the case 2, and are fixed by, for example, ultrasonic welding or the like. The And the liquid-tightness of the cap members 7 and 9 is ensured by the sealing property of the O-ring 23 mounted therein. When the cap members 7 and 9 are attached to the end of the case 2, a blood supply space 24 is provided between the introduction-side cap member 7 and the case 2, and between the outlet-side cap member 9 and the case 2. Each of the blood outlet spaces (not shown) is partitioned.

  The cap members 7 and 9 have the same shape except for the port function. That is, the blood introduction port 6 in the introduction side cap member 7 corresponds to the blood extraction port 8 in the extraction side cap member 9. For this reason, the following description regarding the introduction-side cap member 7 applies to the outlet-side cap member 9 as well. The structure of the introduction side cap member 7 will be described later in detail.

  When the blood purifier 1 having the above-described configuration is used, the blood purifier 1 is fixed with the introduction-side cap member 7 facing upward and the outlet-side cap member 9 facing downward. Then, an arterial blood tube is connected to the blood introduction port 6 of the introduction side cap member 7, and a venous side blood tube is connected to the blood extraction port 8 of the extraction side cap member 9 (both not shown). In addition, a recovery-side treatment liquid tube is connected to the treatment liquid outlet port 14, and an introduction-side treatment liquid tube is connected to the treatment liquid introduction port 13 (both not shown).

  When the patient's blood is supplied to the blood purifier 1 from the blood tube on the artery side, this blood is supplied into the blood supply space 24 through the blood introduction path 6 a in the blood introduction port 6. The blood supplied to the blood supply space 24 then flows down the blood flow path in each hollow fiber 7, and the blood outlet space of the outlet side cap member 9 (the space corresponding to the blood supply space 24 of the inlet side cap member 7). To leak. The blood that has flowed into the blood outlet space is guided to a blood tube on the venous side through a blood outlet path (not shown) of the blood outlet port 8 and returned to the patient's body. On the other hand, when the treatment liquid from the treatment liquid tube on the introduction side is supplied to the blood purifier 1, the treatment liquid is supplied to the treatment liquid flow path outside the hollow fiber 7 through the treatment liquid introduction port 13. Thereafter, the processing liquid flows into the processing-side processing liquid tube from the processing liquid outlet port and is recovered.

  At this time, substance exchange is performed between the blood channel and the treatment solution channel by osmotic pressure or the like. Then, the processed blood that has undergone substance exchange is returned to the patient's body. Specifically, the excess component in the blood passes through the hollow fiber 7 and moves to the treatment liquid side, and the insufficient component in the blood passes through the hollow fiber 7 and moves to the blood side.

  In this case, in order to increase the blood processing efficiency, it is desirable to supply blood evenly to the hollow fibers constituting the hollow fiber bundle 3. In order to prevent thrombus formation in the blood supply space 24, it is desirable to increase the flow rate of blood flowing in the vicinity of the wall surface of the blood supply space 24 to prevent blood from staying in the blood supply space 24. In view of this point, in the present embodiment, a resistance portion is provided on the ceiling surface so as to bulge toward the end surface of the hollow fiber bundle 3, and the blood introduction port 6 is provided toward the outside of the region where the resistance portion faces. Provided. Hereinafter, this point will be described in detail.

  First, the structure of the cap members 7 and 9 will be described using the introduction-side cap member 7 as an example. Here, FIGS. 3 and 4 are diagrams illustrating the structure of the introduction-side cap member 7. Specifically, FIG. 3A is a cross-sectional view of the introduction-side cap member 7 cut, showing a part of the blood introduction port 6 in cross-section, and FIG. 3B is a bottom view. 4A is a right side view, FIG. 4B is a left side view, and FIG. 4C is a plan view. As described above, since the introduction-side cap member 7 and the outlet-side cap member 9 have the same shape, the following description of the introduction-side cap member 7 is the same for the outlet-side cap member 9.

  As shown in these drawings, the introduction-side cap member 7 includes a main body portion 27 and a blood introduction port 6 and is integrally formed of resin. In the present embodiment, similarly to the case 2, it is made of a synthetic resin material such as polycarbonate and olefin resin (for example, polypropylene).

  The main body portion 27 includes a substantially circular ceiling portion 28 and a substantially cylindrical body portion 29 that stands up from the periphery of the ceiling portion 28 and surrounds the outer peripheral surface of the cap mounting portion 20 of the case 2. The female threaded portion 21 is engraved on the inner peripheral surface of the body portion 29.

  As for the ceiling part 28, the surface inside a cap functions as a ceiling surface of this invention. And the resistance part 32 is provided in the approximate center of this ceiling surface. The resistance portion 32 is produced by bulging a part of the ceiling portion 28 toward the end face side of the hollow fiber bundle 3 (that is, the open end portion side of the body portion 29). In the present embodiment, the resistance portion 32 has a substantially conical shape whose height is lower than the size of the bottom surface, and is provided in the center portion of the ceiling surface. With the resistance portion 32, the apex of the resistance portion 32 is closest to the end surface of the hollow fiber bundle 3 in the mounted state of the introduction side cap member 7. And the distance from the resistance part surface to the end surface of the hollow fiber bundle 3 becomes longer as it is separated from the apex in the radial direction. In other words, with respect to the height of the blood supply space 24, the height of the outer region 24 </ b> A located outside the outer edge portion of the resistance portion 32 is higher than the height of the facing region 24 </ b> B facing the resistance portion 32. Therefore, the flow resistance of the blood flowing through the outer region 24A is smaller than the flow resistance of the blood flowing through the facing region 24B.

  Furthermore, in this embodiment, the concave groove 33 is formed by denting the ceiling portion 28 located in the outer region 24A. The concave groove 33 is provided in an arc shape surrounding the resistance portion 32. The concave groove 33 is provided in a spiral shape. That is, the height from the concave groove 33 to the end face of the hollow fiber bundle 3 is the highest in the vicinity of the outlet 6b of the blood introduction path 6a and gradually decreases as the distance from the outlet 6b increases. In other words, it can be said that the groove depth of the concave groove 33 is gradually reduced. Furthermore, the width of the concave groove 33 is configured to be narrower toward the tip, that is, away from the boundary with the blood introduction port 6. By providing such a concave groove 33, the flow path resistance of the outer region 24 </ b> A is also reduced by the concave groove 33. In addition, since the concave groove 33 is provided in a spiral shape and is gradually reduced in width, it is possible to positively generate a blood vortex in the blood supply space 24.

  A circular mounting groove 34 is formed inside the introduction-side cap member 7 and at the boundary between the ceiling portion 28 and the body portion 29. The mounting groove 34 is a groove for storing the O-ring 13, has a substantially semicircular cross section, and makes a round so as to surround the concave groove 33.

Further, the blood introduction port 6 is provided laterally on the outer surface of the ceiling portion 28, and a blood introduction path 6 a communicating with the inner space of the main body portion 27 (that is, the blood supply space 24) is opened inside. More specifically, as shown in FIGS. 3 and 4, the blood introduction port 6 has a portion on the inlet side (right side in FIG. 3 (a)) of the blood introduction path 6 a that is the end of the case 2 and the hollow fiber bundle 3. The blood introduction port 6 is provided in a state of being eccentric from the center of the blood supply space 24. Here, the state eccentric from the center of the blood supply space 24 is a state formed by shifting the position in the direction perpendicular to the virtual center line with respect to the virtual center line in the radial direction.
In this embodiment, the center line of the introduction-side cap member 7 is a virtual center line L, and the blood introduction port 6 is shifted from the virtual center line L by a predetermined distance ΔL, that is, formed in an offset state. doing. Thereby, the outlet 6b of the blood introduction path 6a is opened in the concave groove 33 (inside the outer region 24A in the blood supply space 24). In other words, the blood introduction port 6 is formed with the blood introduction path 6a toward the outer region 24A (see FIG. 3B).

  When the introduction-side cap member 7 having such a structure is used, the blood introduction path 6a of the blood introduction port 6 is provided toward the outer region 24A (corresponding to the outside of the outer edge portion of the resistance portion in the present invention). The blood that has passed through the blood introduction path 6a is efficiently introduced into the outer region 24A. In the blood supply space 24, the flow resistance of the outer region 24A is smaller than the flow resistance of the opposing region 24B, so that the introduced blood flows so as to surround the resistance portion 32 along the outer region 24A. By this flow, blood can be evenly distributed over the entire area of the end surface of the hollow fiber bundle 3. In the present embodiment, since the blood introduction port 6 is provided in an eccentric state, the blood introduced from the blood introduction port 6 is likely to cause a vortex in the blood supply space 24, and the blood in the outer region 24A. Can be made faster. Thereby, the adhesion of the protein present in the blood to the wall surface of the blood supply space 24 can be reliably prevented. Therefore, it is possible to prevent blood from staying in the blood supply space 24 and make it difficult to form a thrombus.

  Moreover, since the said resistance part 32 is arrange | positioned in the center part of the ceiling surface, the blood supply space 24 becomes the center part in a hollow fiber bundle end surface the lowest, and becomes high as it goes outside from this position. For this reason, the center of the blood flow in the outer region 24A can be aligned with the center of the end face of the hollow fiber bundle. As a result, blood can be reliably distributed to the hollow fibers 7 constituting the hollow fiber bundle 3.

  By the way, the present invention is not limited to the above embodiment, and various modifications can be made based on the description of the scope of claims. For example, as shown in FIG. 5, the resistance portion 41 may be arranged eccentric from the center of the ceiling surface. In the illustrated embodiment, a conical resistance portion 41 having a diameter about ½ of the inner diameter of the body portion 29 is used, and the resistance portion 41 is provided at a position close to the outlet 6b side of the blood introduction path 6a. Yes. In this embodiment, the resistance portion 32 is eccentric to the outlet 6b side of the blood introduction path 6a, so that the blood flowing into the blood supply space 24 from the blood introduction path 6a is sent without reducing the flow rate as much as possible. Can do. By adjusting the flow of blood in this way, it is possible to prevent the formation of thrombus caused by the retention of blood and to make the non-uniform flow of blood uniform.

  Further, as shown in FIG. 6, the resistance portion may be an elliptical resistance portion (conical shape with an elliptical bottom), or may be a resistance portion 43 that is raised in a crescent shape as shown in FIG. 7. Good. In any form, blood flow can be adjusted. In any case, the blood introduction port 6 is provided toward the outside of the region where the resistance portions 42 and 43 face each other.

  Further, regarding the cap members 7 and 9, in the above embodiments, the introduction side cap member 7 is provided with the blood introduction port 6 and the derivation side cap member 9 is provided with the blood derivation port 8. It is not limited to this. That is, the introduction side cap member 7 may be provided with the blood introduction port 6 and the treatment liquid outlet port 14, and the outlet side cap member 9 may be provided with the blood outlet port 8 and the treatment liquid introduction port 13.

  In addition, in each of the above embodiments, an example in which the introduction-side cap member 7 and the outlet-side cap member 9 have the same shape has been described. However, if the introduction-side cap member includes the blood introduction port and the resistance portion described above. The introduction-side cap member and the outlet-side cap member may have different shapes.

  In the above embodiment, the blood purifier 1 as a dialyzer has been described as an example, but the present invention is not limited to this. For example, the present invention may be applied to a blood purifier that does not have a treatment liquid introduction port and that extracts plasma extracted from blood through a hollow fiber through a treatment liquid outlet port, that is, a plasma separation filter. The blood purifier is provided with one blood introduction port communicating with the inner space of the hollow fiber and one outlet port communicating with the outer space of the hollow fiber, the blood flowing in from the introduction port by a semipermeable membrane. It may be applied to a filter for filtering out foreign substances in blood by flowing out from the outlet port, that is, a filter. In short, the present invention can be applied to any blood purifier provided with at least one blood introduction port and at least one treatment liquid port for deriving blood treated with hollow fibers or components in the blood. .

It is sectional drawing of a blood purifier. It is a partial expanded sectional view explaining a case front-end | tip part and an introduction side cap member. (A) is sectional drawing which cut | disconnected the introduction side cap member in the position of the process liquid derivation | leading port, Comprising: The figure which also showed a part of blood introduction port in cross section, (b) is a bottom view. It is explanatory drawing of an introduction side cap member, (a) is a right view, (b) is a left view, (c) is a top view. It is a figure explaining embodiment arrange | positioned eccentrically from the center of a ceiling surface, (a) is sectional drawing, (b) is a bottom view. It is a figure explaining an elliptical cone-shaped resistance part. It is a figure explaining the resistance part which protruded in the crescent moon shape.

Explanation of symbols

DESCRIPTION OF SYMBOLS 1 Blood purifier 2 Case 3 Hollow fiber bundle 6 Blood introduction port 6a Blood introduction path 6b Outlet 7 Inlet side cap member 8 Blood outlet port 9 Outlet side cap member 10 Potting part 11 Hollow fiber membrane 13 Processing liquid introduction port 14 Processing liquid outlet Port 20 Cap mounting portion 21 Female screw portion 22 Male screw portion 23 O-ring 24 Blood supply space 24A Outside region of blood supply space 24B Opposing region 27 of blood supply space 27 Main body portion 28 Ceiling portion 29 Body portion 32 Resistance portion 33 Concave groove 34 Mounting groove 41-43 Resistor

Claims (4)

A hollow fiber bundle of a semipermeable hollow fiber is loaded into a cylindrical case, and both ends of the hollow fiber bundle are potted on the inner surface of the case so that the inside of the case is connected to the blood flow path inside the hollow fiber and the hollow fiber bundle. It is partitioned into an outer processing liquid flow path, cap members are attached in a liquid-tight manner to both ends of the case, and provided with a blood introduction port communicating with the blood flow path, and a processing liquid port communicating with the processing liquid flow path A hollow fiber blood purifier in which a blood supply space is formed between the end surface of the hollow fiber bundle and the ceiling surface of the cap member, and before blood introduced from the blood introduction port flows into the blood flow path. ,
Forming a resistance part bulging toward the end face side of the hollow fiber bundle on the ceiling surface of the cap member, and providing a blood introduction port outside the outer edge of the resistance part in the blood supply space; A hollow fiber blood purifier.   The resistance portion is disposed in the center portion of the ceiling surface, and the distance between the outer ceiling surface of the resistance portion and the end surface of the hollow fiber bundle is set to be larger than the distance between the resistance portion and the end surface of the hollow fiber bundle. The hollow fiber blood purifier according to claim 1, wherein a blood introduction port is provided toward a region having a space.   The hollow fiber blood purifier according to claim 1, wherein the resistance portion is arranged eccentrically from the center of the ceiling surface. The said blood introduction port is provided in the state eccentric from the center of the blood supply space so that the blood introduced into the blood supply space may become a vortex. Hollow fiber blood purifier.

Images