JP2005237441A5 - - Google Patents

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JP2005237441A5
JP2005237441A5 JP2004047640A JP2004047640A JP2005237441A5 JP 2005237441 A5 JP2005237441 A5 JP 2005237441A5 JP 2004047640 A JP2004047640 A JP 2004047640A JP 2004047640 A JP2004047640 A JP 2004047640A JP 2005237441 A5 JP2005237441 A5 JP 2005237441A5
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diagnosis support
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被検者の脳画像を入力し、画像処理して診断結果を提示することにより診断の支援を行なう脳疾患の診断支援方法であって、
統計的手法により、疾患毎の関心領域であるＲＯＩを、標準化脳画像上のボクセルの集合として決定する段階と、
入力された被検者の脳画像と、予め用意されている健常者の脳画像との統計的比較を、標準化脳画像上において前記ＲＯＩを適用して行なう段階と、
得られた統計的比較結果を診断支援情報として数量的に提示する段階と、を含むことを特徴とする脳疾患の診断支援方法。 A brain disease diagnosis support method for supporting diagnosis by inputting a brain image of a subject, performing image processing and presenting a diagnosis result,
The statistical method, determining the ROI is a region of interest sputum 患毎, as a set of voxels on standardized brain image,
A subject's brain image input, the steps of a statistical comparison between healthy subjects brain image which is prepared in advance, is performed by applying the ROI on standardized brain image,
A method of quantitatively presenting the obtained statistical comparison results as diagnosis support information, and a method for supporting diagnosis of brain disease, comprising : 前記統計的比較を、脳全体に対して併せて行ない、前記ＲＯＩを適用して得られた比較結果と、脳全体に関する比較結果をそれぞれ診断支援情報とすることを特徴とする請求項１に記載の脳疾患の診断支援方法。 Claim 1, the statistical comparisons, rows that have together for the entire brain, compares results obtained by applying the ROI, characterized in that the respective diagnosis support information comparison result for the entire brain The method for assisting diagnosis of brain disease according to claim 1. 前記統計的比較を、ボクセル毎にＺスコアを算出して行ない、Ｚスコアに基づいて該ボクセルが異常か否かを判定することを特徴とする請求項１又は２に記載の脳疾患の診断支援方法。 The statistical comparison, rows that have been calculated Z score for each voxel, the brain disease according to claim 1 or 2, characterized in that determining whether the voxel is abnormal based on the Z score Diagnosis support method. 異常と判定されたボクセルを計数し、該ボクセル数を前記統計的比較結果に含めることを特徴とする請求項３に記載の脳疾患の診断支援方法。 Diagnosis support method of brain diseases according to claim 3, counting the voxels is determined abnormal, and wherein the inclusion of number of the voxels in the statistical comparison. 異常と判定されたボクセルのＺスコアの平均を算出し、該平均値を前記統計的比較結果に含めることを特徴とする請求項３に記載の脳疾患の診断支援方法。 Diagnosis support method of brain diseases according to claim 3, calculates the average of the Z score of voxels it is determined that abnormality, characterized in that inclusion of the average value to the statistical comparison. 前記脳画像が、ＭＲＩ脳画像であることを特徴とする請求項１乃至５のいずれか１項に記載の脳疾患の診断支援方法。 The brain image diagnosis support method of the brain disease according to any one of claims 1 to 5, characterized in that an MRI brain images. 被検者のＭＲＩ脳画像を入力した後、
該ＭＲＩ脳画像から灰白質組織を抽出して灰白質脳画像を作成し、
該灰白質脳画像に解剖学的標準化を施した後、前記統計的比較を行なうことを特徴とする請求項６に記載の脳疾患の診断支援方法。 After inputting the MRI brain image of the subject,
Extracting gray matter tissue from the MRI brain image to create a gray matter brain image;
7. The brain disease diagnosis support method according to claim 6, wherein the statistical comparison is performed after anatomical standardization is performed on the gray matter brain image. 被検者のＭＲＩ脳画像を入力した後、
該ＭＲＩ脳画像に、解剖学的標準化を施し、
該標準化後のＭＲＩ脳画像から灰白質組織を抽出して灰白質脳画像を作成した後、前記統計的比較を行なうことを特徴とする請求項６に記載の脳疾患の診断支援方法。 After inputting the MRI brain image of the subject,
Anatomic standardization is applied to the MRI brain image,
The diagnosis support method for a brain disease according to claim 6, wherein the statistical comparison is performed after gray matter tissue is extracted from the standardized MRI brain image to create a gray matter brain image. 被検者のＭＲＩ脳画像を入力し、画像処理して診断結果を提示することによりアルツハイマー型痴呆に対する診断の支援を行なう脳疾患の診断支援方法であって、  A brain disease diagnosis support method for supporting diagnosis of Alzheimer-type dementia by inputting an MRI brain image of a subject, processing the image, and presenting a diagnosis result,
統計的手法により、アルツハイマー型痴呆の関心領域であるＲＯＩを、標準化脳画像上のボクセルの集合として決定する段階と、  Determining a ROI that is a region of interest for Alzheimer-type dementia as a set of voxels on a standardized brain image by a statistical method;
入力された被検者の脳画像と、予め用意されている健常者の脳画像との統計的比較を、標準化脳画像上において前記ＲＯＩを適用して行なう段階と、  Performing a statistical comparison between the input brain image of the subject and the brain image of a healthy person prepared in advance by applying the ROI on the standardized brain image;
該統計的比較の結果異常と判定されたボクセルのＺスコアの平均値を、診断支援情報として提示する段階と、を含むことを特徴とする脳疾患の診断支援方法。  A method for supporting a diagnosis of brain disease, comprising the step of presenting, as diagnosis support information, an average value of Z scores of voxels determined to be abnormal as a result of the statistical comparison. 被検者の脳画像を入力し、画像処理して診断結果を出力することにより診断の支援を行なう脳疾患の診断支援装置であって、
統計的手法により、標準化脳画像上のボクセルの集合として決定された、疾患毎の関心領域であるＲＯＩを保存する保存手段と、
入力された被検者の脳画像と、予め作成されている健常者の脳画像との統計的比較を、標準化脳画像上において前記保存手段から読み出した診断対象の疾患についてのＲＯＩを適用して行い、比較結果を表すいくつかの指標となる値を算出する画像・統計処理手段と、
前記統計的比較結果を診断支援情報として表示する結果表示手段と、を備えていることを特徴とする脳疾患の診断支援装置。 A brain disease diagnosis support apparatus that supports diagnosis by inputting a brain image of a subject, processing the image, and outputting a diagnosis result,
The statistical method was determined as a set of voxels on standardized brain image, and storage means for save the ROI is a region of interest for each disease,
Statistical comparison between the brain image of the input subject and the brain image of a healthy person prepared in advance is applied to the ROI for the disease to be diagnosed read from the storage means on the standardized brain image. An image / statistical processing means for calculating values that serve as some indexes representing the comparison results,
A diagnosis support apparatus for brain disease, comprising: a result display means for displaying the statistical comparison result as diagnosis support information . 前記統計的比較を、脳全体に対して併せて行ない、前記ＲＯＩを適用して得られた比較結果と、脳全体に関する比較結果をそれぞれ診断支援情報とすることを特徴とする請求項１０に記載の脳疾患の診断支援装置。 Claim 1, the statistical comparisons, rows that have together for the entire brain, compares results obtained by applying the ROI, characterized in that the respective diagnosis support information comparison result for the entire brain The diagnosis support apparatus for brain disease according to 0. 前記統計的比較を、ボクセル毎にＺスコアを算出して行ない、Ｚスコアに基づいて該ボクセルが異常か否かを判定することを特徴とする請求項１０又は１１に記載の脳疾患の診断支援装置。 The statistical comparison, rows that have been calculated Z score for each voxel, the brain disease according to claim 10 or 11, wherein the determining whether the voxel is abnormal based on the Z score Diagnosis support device. 異常と判定されたボクセルを計数し、該ボクセル数を前記統計的比較結果に含めることを特徴とする請求項１２に記載の脳疾患の診断支援装置。 Counted voxels is determined abnormal, the diagnosis support device of the brain disease according to claim 12, wherein the inclusion of number of the voxels in the statistical comparison. 異常と判定されたボクセルのＺスコアの平均を算出し、該平均値を前記統計的比較結果に含めることを特徴とする請求項１２に記載の脳疾患の診断支援装置。 Calculating the average of the Z score of voxels is determined abnormal, the diagnosis support device of the brain disease according to claim 12, characterized in that inclusion of the average value to the statistical comparison. 前記脳画像が、ＭＲＩ脳画像であることを特徴とする請求項１０乃至１４のいずれか１項に記載の脳疾患の診断支援装置。 The brain image diagnosis assisting apparatus of brain disease according to any one of claims 10 to 14, characterized in that the MRI brain image. 被検者のＭＲＩ脳画像を入力した後、
該ＭＲＩ脳画像から灰白質組織を抽出して灰白質脳画像を作成し、
該灰白質脳画像に解剖学的標準化を施した後、前記統計的比較を行なうことを特徴とする請求項１５に記載の脳疾患の診断支援装置。 After inputting the MRI brain image of the subject,
Extracting gray matter tissue from the MRI brain image to create a gray matter brain image;
16. The brain disease diagnosis support apparatus according to claim 15 , wherein the statistical comparison is performed after the gray matter brain image is subjected to anatomical standardization. 被検者のＭＲＩ脳画像を入力した後、
該ＭＲＩ脳画像に、解剖学的標準化を施し、
該標準化後のＭＲＩ脳画像から灰白質組織を抽出して灰白質脳画像を作成した後、前記統計的比較を行なうことを特徴とする請求項１５に記載の脳疾患の診断支援装置。 After inputting the MRI brain image of the subject,
Anatomic standardization is applied to the MRI brain image,
16. The brain disease diagnosis support apparatus according to claim 15 , wherein the statistical comparison is performed after extracting gray matter tissue from the standardized MRI brain image to create a gray matter brain image. 請求項１乃至９に記載の脳疾患の診断支援方法をコンピュータで実施するためのコンピュータ読取可能なプログラム。 Computer-readable program for executing the diagnosis support method of brain diseases described computer to claims 1 to 9. 請求項１０乃至１７に記載の脳疾患の診断支援装置をコンピュータで実現するためのコンピュータ読取可能なプログラム。 Computer-readable program for implementing by a computer diagnosis support device of brain diseases according to claims 10 to 17. 請求項１８又は１９に記載のプログラムが格納された記録媒体。 A recording medium in which the program according to claim 18 or 19 is stored.
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