JP2005206503A5 - - Google Patents
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- JP2005206503A5 JP2005206503A5 JP2004013692A JP2004013692A JP2005206503A5 JP 2005206503 A5 JP2005206503 A5 JP 2005206503A5 JP 2004013692 A JP2004013692 A JP 2004013692A JP 2004013692 A JP2004013692 A JP 2004013692A JP 2005206503 A5 JP2005206503 A5 JP 2005206503A5
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Description
本発明方法においては、反応媒体として、テトラアルキルアンモニウム塩系溶媒、テトラアルキルホスホニウム塩系溶媒、Ｎ‐メチル，Ｎ´‐Ｃ4〜Ｃ8アルキル‐イミダゾリウム塩系溶媒、Ｎ‐アルキルピリジニウム塩系溶媒を用いるのが好ましい。
また、原料の環状アミンとしては、アジリジン類、アゼチジン類、ピロリジン類、ピペリジン類を用いるのがよく、中でもアジリジン類、アゼチジン類を用いるのが、所期の効果をより良好に奏しうるので好ましい。
更に、反応にはオートクレーブ等の耐圧容器を用いるのが好ましく、環状ウレタンを良好な収率で得るには、ハロゲン、中でもヨウ素を触媒とするのがよい。
また、反応条件については、反応温度を０℃〜２００℃、より好ましくは二酸化炭素を超臨界状態下とする、３１．１℃〜２００℃、圧力を常圧〜１００ＭＰａ、より好ましくは二酸化炭素を超臨界状態下とする、７．３８ＭＰａ〜１００ＭＰａの範囲とするのが好ましい。
In the method of the present invention, tetraalkylammonium salt solvent, tetraalkylphosphonium salt solvent, N-methyl, N′-C 4 -C 8 alkyl-imidazolium salt solvent, N-alkylpyridinium salt solvent are used as the reaction medium. It is preferable to use a solvent.
Further, as the raw material cyclic amine, aziridines, azetidines, pyrrolidines, and piperidines are preferably used, and among them, aziridines and azetidines are preferably used because the desired effects can be further improved.
Furthermore, it is preferable to use a pressure vessel such as an autoclave for the reaction. In order to obtain cyclic urethane in a good yield, it is preferable to use halogen, especially iodine as a catalyst.
Regarding the reaction conditions, the reaction temperature is 0 ° C. to 200 ° C., more preferably 31.1 ° C. to 200 ° C. with carbon dioxide in a supercritical state, the pressure is atmospheric pressure to 100 MPa, more preferably carbon dioxide. It is preferable to be in the range of 7.38 MPa to 100 MPa under the supercritical state.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2004013692A JP4324669B2 (en) | 2004-01-21 | 2004-01-21 | Method for producing cyclic urethane |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2004013692A JP4324669B2 (en) | 2004-01-21 | 2004-01-21 | Method for producing cyclic urethane |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2005206503A JP2005206503A (en) | 2005-08-04 |
| JP2005206503A5 true JP2005206503A5 (en) | 2007-05-17 |
| JP4324669B2 JP4324669B2 (en) | 2009-09-02 |
Family
ID=34899681
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2004013692A Expired - Lifetime JP4324669B2 (en) | 2004-01-21 | 2004-01-21 | Method for producing cyclic urethane |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JP4324669B2 (en) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8835426B2 (en) | 2007-02-26 | 2014-09-16 | Vitae Pharmaceuticals, Inc. | Cyclic urea and carbamate inhibitors of 11β-hydroxysteroid dehydrogenase 1 |
| EP2183228B1 (en) | 2007-07-26 | 2014-08-20 | Vitae Pharmaceuticals, Inc. | CYCLIC INHIBITORS OF 11ß -HYDROXYSTERIOD DEHYDROGENASE 1 |
| CA2708303A1 (en) | 2007-12-11 | 2009-06-18 | Vitae Pharmaceuticals, Inc. | Cyclic urea inhibitors of 11.beta.-hydroxysteroid dehydrogenase 1 |
| TW200934490A (en) | 2008-01-07 | 2009-08-16 | Vitae Pharmaceuticals Inc | Lactam inhibitors of 11 &abgr;-hydroxysteroid dehydrogenase 1 |
| JP5490020B2 (en) | 2008-01-24 | 2014-05-14 | ヴァイティー ファーマシューティカルズ，インコーポレイテッド | Cyclic carbazate and semicarbazide inhibitors of 11β-hydroxysteroid dehydrogenase 1 |
| WO2009102428A2 (en) | 2008-02-11 | 2009-08-20 | Vitae Pharmaceuticals, Inc. | 1,3-OXAZEPAN-2-ONE AND 1,3-DIAZEPAN-2-ONE INHIBITORS OF 11β -HYDROXYSTEROID DEHYDROGENASE 1 |
| WO2009102460A2 (en) | 2008-02-15 | 2009-08-20 | Vitae Pharmaceuticals, Inc. | Inhibitors of 11beta-hydroxysteroid dehydrogenase 1 |
| CA2723039A1 (en) | 2008-05-01 | 2009-11-05 | Vitae Pharmaceuticals, Inc. | Cyclic inhibitors of 11beta-hydroxysteroid dehydrogenase 1 |
| EP2291373B1 (en) | 2008-05-01 | 2013-09-11 | Vitae Pharmaceuticals, Inc. | Cyclic inhibitors of 11beta-hydroxysteroid dehydrogenase 1 |
| JP5301563B2 (en) | 2008-05-01 | 2013-09-25 | ヴァイティー ファーマシューティカルズ，インコーポレイテッド | Cyclic inhibitor of 11β-hydroxysteroid dehydrogenase 1 |
| EP2291370B1 (en) | 2008-05-01 | 2013-11-27 | Vitae Pharmaceuticals, Inc. | Cyclic inhibitors of 11beta-hydroxysteroid dehydrogenase 1 |
| NZ590495A (en) | 2008-07-25 | 2012-10-26 | Vitae Pharmaceuticals Inc | Dihydropyridin-phenyl-3-oxazinan-2-ones as inhibitors of 11beta-hydroxysteroid dehydrogenase 1 |
| TW201016691A (en) | 2008-07-25 | 2010-05-01 | Boehringer Ingelheim Int | Inhibitors of 11beta-hydroxysteroid dehydrogenase 1 |
| CA2744946A1 (en) | 2009-02-04 | 2010-08-12 | Boehringer Ingelheim International Gmbh | Cyclic inhibitors of 11.beta.-hydroxysteroid dehydrogenase 1 |
| UA109255C2 (en) | 2009-04-30 | 2015-08-10 | Берінгер Інгельхайм Інтернешнл Гмбх | Cyclic inhibitors of 11beta-hydroxysteroid dehydrogenase 1 |
| WO2011011123A1 (en) | 2009-06-11 | 2011-01-27 | Vitae Pharmaceuticals, Inc. | Cyclic inhibitors of 11beta-hydroxysteroid dehydrogenase 1 based on the 1,3 -oxazinan- 2 -one structure |
| EP2448928B1 (en) | 2009-07-01 | 2014-08-13 | Vitae Pharmaceuticals, Inc. | Cyclic inhibitors of 11beta-hydroxysteroid dehydrogenase 1 |
| KR101102537B1 (en) | 2009-07-31 | 2012-01-04 | 재단법인 포항산업과학연구원 | Preparing method of dialkyl carbonate |
| US8933072B2 (en) | 2010-06-16 | 2015-01-13 | Vitae Pharmaceuticals, Inc. | Substituted 5-,6- and 7-membered heterocycles, medicaments containing such compounds, and their use |
| JP5813106B2 (en) | 2010-06-25 | 2015-11-17 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | Azaspirohexanone as an inhibitor of 11-β-HSD1 for the treatment of metabolic disorders |
| CA2813671A1 (en) | 2010-11-02 | 2012-05-10 | Boehringer Ingelheim International Gmbh | Pharmaceutical combinations for the treatment of metabolic disorders |
| CN108554456B (en) * | 2016-09-20 | 2021-02-12 | 苏州大学 | Application of rare earth imidazolium salt compound as catalyst |
-
2004
- 2004-01-21 JP JP2004013692A patent/JP4324669B2/en not_active Expired - Lifetime
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