JP2005206474A - Composition for scalp and hair - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To provide an excellently safe composition for the scalp and hair having excellent prophylactic effects on production of gray hair and ameliorating effects on the gray hair and an excellent feeling of use. <P>SOLUTION: The composition for the scalp and hair comprises an alkylene oxide derivative represented by chemical formula (I); R<SP>1</SP>O-[(AO)<SB>m</SB>(EO)<SB>n</SB>]-R<SP>2</SP>äwherein, AO is a 3-4C oxyalkylene group; EO is an oxyethylene group; 1≤m≤70; 1≤n≤70; the ratio of the EO group based on the total of the AO group and EO group is 20-80 mass%; the AO group and EO group may be added in a block form or a random form; R<SP>1</SP>and R<SP>2</SP>are each the same or different and are each a 1-4C hydrocarbon group or a hydrogen atom; and the ratio of the number of hydrogen atoms based on the number of the hydrocarbon groups in R<SP>1</SP>and R<SP>2</SP>is ≤0.15}, a tyrosinase activity promoter and a local stimulant. <P>COPYRIGHT: (C)2005,JPO&NCIPI

Description

  The present invention relates to a scalp hair composition, and more particularly to a scalp hair composition comprising an alkylene oxide derivative.

Tyrosinase is an indispensable enzyme for biosynthesis of melanin from tyrosine in human skin, and is a phenomenon caused by excessive exposure to sunlight and ultraviolet rays on parts such as the face and arms. It is known to be deeply involved in the formation of "freckle".
In addition, this tyrosinase is deeply involved in scalp blackening (darkening), and it has been clarified that a decrease in tyrosinase activity in the scalp is one of the causes of graying.

Therefore, various attempts have been made to suppress the generation of white hair or improve white hair by promoting the activity of tyrosinase (Patent Documents 1 to 6).
JP-A-5-78222 JP-A-7-285874 Japanese Patent Laid-Open No. 7-316026 Japanese Unexamined Patent Publication No. 7-112978 JP 7-126129 A JP 2001-131033 A

However, in the conventionally proposed technology, sufficient effects are not obtained and it cannot be said that it is necessarily effective in improving gray hair, or although the effects are recognized, it is sufficiently satisfactory in terms of use feeling and safety. There was a problem that it was not a thing.
The present invention has been made in view of the above-described conventional problems, and an object thereof is to provide a composition for scalp and hair that has excellent white hair generation prevention and white hair improvement effects, and is excellent in safety and use feeling. is there.

As a result of intensive studies by the present inventors in order to achieve the above-mentioned object, a combination of a tyrosinase activity promoter and a local stimulant and an alkylene oxide derivative having a specific structure exerts an excellent effect on the scalp and hair. Furthermore, the present inventors have found that a composition excellent in safety and use feeling can be obtained, and completed the present invention.
That is, the scalp hair composition according to the present invention comprises an alkylene oxide derivative represented by the following chemical formula (I):
A tyrosinase activity promoter;
It contains a local stimulant.

(Chemical formula 1)
_{^{R 1 O - [(AO)}} m (EO) n] -R 2 (I)
(In the formula, AO is an oxyalkylene group having 3 to 4 carbon atoms, EO is an oxyethylene group, m and n are average addition moles of the oxyalkylene group and oxyethylene group, respectively, 1 ≦ m ≦ 70, 1 ≦ n ≦ 70 The ratio of the oxyethylene group to the total of the oxyalkylene group having 3 to 4 carbon atoms and the oxyethylene group is 20 to 80 mass% The oxyalkylene group and oxyethylene group having 3 to 4 carbon atoms R ¹ and R ² may be the same or different, and may be the same or different, a C 1-4 hydrocarbon group or a hydrogen atom, and R ¹ and R ² may be added in a block form or in a random form. (The ratio of the number of hydrogen atoms to the number of hydrocarbon groups of R ² is 0.15 or less.)

In the present invention, it is preferable that the oxyalkylene group and the oxyethylene group of the alkylene oxide derivative are added randomly.
In the composition, the amount of the alkylene oxide derivative is preferably 0.01 to 20% by mass.
In the composition, the tyrosinase activity promoter is preferably a solvent extract of one or more kinds of plants selected from the group consisting of salamander, cayurape, guacomist, Aritasou, zapote, axcopaque, and hops. is there.
In this invention, it is suitable that the compounding quantity of a tyrosinase activity promoter is 0.00001-10.0 mass%.

In the composition, the local stimulant is preferably one or more selected from the group consisting of cantalis tincture, ginger tincture, carrot extract, chili pepper tincture, menthol, camphor and nonylic acid vanillylamide. .
In this invention, it is suitable that the compounding quantity of a local stimulant is 0.00001-5.0 mass%.
The composition can be used as an anti-white hair cosmetic.

  According to the scalp scalp hair composition of the present invention, by using a tyrosinase activity promoter and a local stimulant in combination with an alkylene oxide derivative having a specific structure, it has an excellent effect on preventing the occurrence of white hair and improving white hair, and A composition for scalp and hair excellent in safety and use feeling can be obtained.

<Alkylene oxide derivatives>
In the alkylene oxide derivative represented by the general formula (I), which is characteristic in the present invention, AO is an oxyalkylene group having 3 to 4 carbon atoms, specifically, an oxypropylene group, an oxybutylene group, an oxyisobutylene group. Oxytrimethylene group, oxytetramethylene group and the like. Preferably, an oxypropylene group and an oxybutylene group are mentioned.
m is the average number of added moles of an oxyalkylene group having 3 to 4 carbon atoms, and 1 ≦ m ≦ 70. n is the average number of added moles of oxyethylene groups, and 1 ≦ n ≦ 70. When the oxyalkylene group or oxyethylene group having 3 to 4 carbon atoms is 0, the moist feeling is lowered, and when it exceeds 70, a sticky feeling tends to appear.

Moreover, it is preferable that the ratio of the oxyethylene group with respect to the sum total of a C3-C4 oxyalkylene group and an oxyethylene group is 20-80 mass%. When the proportion of the oxyethylene group is less than 20% by mass, the moisture feeling tends to be inferior, and when it exceeds 80% by mass, stickiness after use tends to occur.
The order of adding ethylene oxide and alkylene oxide having 3 to 4 carbon atoms is not particularly specified. Further, the oxyethylene group and the oxyalkylene group having 3 to 4 carbon atoms may be added in a block shape or in a random shape. The block shape includes not only two-stage blocks but also three or more stages.
It is preferable that the oxyethylene group and the oxyalkylene group having 3 to 4 carbon atoms are randomly added. Random ones are superior in use feeling compared to block ones.

R ¹ and R ² are each a hydrocarbon group having 1 to 4 carbon atoms or a hydrogen atom, and examples of the hydrocarbon group include a methyl group, an ethyl group, an n-propyl group, an isopropyl group, an n-butyl group, a sec-butyl group, Examples thereof include a tert-butyl group. A methyl group and an ethyl group are preferred. Hydrocarbon groups having 5 or more carbon atoms are less hydrophilic and less moist. R ¹ and R ² may be the same or different.
R ¹ and R ² may be the same type, or a mixture of a hydrocarbon group having 1 to 4 carbon atoms and a hydrogen atom, or a mixture of different hydrocarbon groups having 1 to 4 carbon atoms. Good. However, among the hydrocarbon groups of R ¹ and R ^2, the proportion of hydrocarbon groups and hydrogen atoms is such that the ratio Y / X of the number of hydrogen atoms (Y) to the number of hydrocarbon groups (X) is 0.15. Hereinafter, it is preferably 0.06 or less. When the ratio of Y / X exceeds 0.15, a sticky feeling comes out.

Specific examples of the alkylene oxide derivative of the present invention include POE (9) POP (2) dimethyl ether, POE (14) POP (7) dimethyl ether, POE (10) POP (10) dimethyl ether, POE (6) POP (14 ) Dimethyl ether, POE (15) POP (5) dimethyl ether, POE (25) POP (25) dimethyl ether, POE (27) POP (14) dimethyl ether, POE (55) POP (28) dimethyl ether, POE (36) POP (41) ) Dimethyl ether, POE (7) POP (12) dimethyl ether, POE (17) POP (4) dimethyl ether, POE (9) POB (2) dimethyl ether, POE (14) POB (7) dimethyl ether, POE (10) POP (10) ) Diethyl Ether, POE (10) POP (10) dipropyl ether, POE (10) POP (10) dibutyl ether, and the like.
The POE, POP, and POB are abbreviations for polyoxyethylene, polyoxypropylene, and polyoxybutylene, respectively, and may be abbreviated as follows.

The alkylene oxide derivative of the present invention can be produced by a known method. For example, it can be obtained by subjecting a compound having a hydroxyl group to addition polymerization of ethylene oxide and an alkylene oxide having 3 to 4 carbon atoms, and then subjecting an alkyl halide to an ether reaction in the presence of an alkali catalyst.
Although the compounding quantity of the alkylene oxide derivative to the composition for scalp scalp hair of this invention is not specifically limited, Usually, 0.01-20 mass% with respect to the whole composition, Preferably 0.1-10 mass% is mix | blended. If it is less than 0.01% by mass, the effect of the blending may not be sufficiently exhibited, and if it exceeds 20% by mass, a sticky feeling may be generated after use.

<Tyrosinase activity promoter>
The tyrosinase activity promoter used in the present invention is a salamander (scientific name: Zanthoxylum piperitum (L.) DC), cayurape (also known as Parameria laevigata, scientific name Parameria laevigata), guaco misto (scientific name: Mykania Glomerata) , Pinguica (Scientific name: Arctostaphylos Pugens), Aritasou (Epazote, Scientific name: Chenopodium Ambrosioides L.), Zapote (Scientific name: Poterium Zapote), Axcopaque (Scientific name: Gautheria Acuminata) Can be mentioned. One or more tyrosinase activity promoters can be used.

Particularly preferred is a salamander extract. A salamander is an extract from a salamander (Zanthoxylum piperitum (L.) DC) that belongs to the genus Salamander, and can use fruits (fruits), flowers, leaves, bark, and the like as raw materials. In particular, it is preferable to blend an extract from fruit (peel) into the composition for scalp and hair of the present invention.
The salamander extract can be extracted by an extraction method generally used when extracting a plant-derived extract. That is, an extract (plant extract) can be obtained by subjecting the above-mentioned raw materials to raw solvent or, if necessary, dried and then subjected to solvent extraction as it is or after pulverization.

  The extraction solvent can select the solvent generally used when extracting the component from a plant, and is not specifically limited. For example, hot water or water; lower alcohols such as ethanol, isopropyl alcohol and n-butanol; polyhydric alcohols such as propylene glycol and 1,3-butylene glycol; hydrates of these alcohols; n-hexane, toluene and the like Hydrocarbon solvents and the like can be mentioned, but when a lower alcohol such as ethanol is used as an extraction solvent, the obtained extract can be directly blended with the composition for scalp and hair of the present invention. It is also possible to mix after drying and drying if necessary.

It is also possible to mix commercially available salamander extracts (Havex sanctuary extract (Kaei Kogyo), Falco Rex Sansho (Ichimaru Falcos), Sansho extract (Maruzen Pharmaceutical), etc.).
The following plants can be obtained in the same manner. The cayurape extract is an extract from the Indonesian crude drug Kayurape (Parameria laevigata) belonging to the genus Parameria of the Oleander family, and leaves, stems, flowers, bark, seeds or fruits of this plant, whole plants etc. are extracted from this It can be used as a raw material.

The guacomist extract is an extract from the Brazilian crude drug guacomist (Guacomisto (mikania glomerafa)) belonging to the asteraceae Micania genus, and leaves, stems, flowers, bark, seeds or fruits of this plant, whole plant etc. It can be used as a raw material.
The Pinguica extract is an extract from the Mexican herbal medicine Pinguica (Arctostaphylos pugens) belonging to the genus Ouurushi, and leaves, stems, flowers, bark, seeds or fruits of this plant, whole plants etc. are extracted from this extract. It can be used as a raw material.
The Aritasou extract is an extract from the Mexican herbal medicine Aritasou (Epazote (Chenopodium Ambrosioides L.)) belonging to the genus Azaza, and leaves, stems, flowers, bark, seeds or fruits of this plant, whole plants etc. It can be used as a raw material for the extract, and the whole plant, leaves, and seeds of this plant can be used as this raw material.

The zapote extract is an extract from the medicinal herb Zapote (Zapote (Poterium zapote)) belonging to the genus Poterium, and leaves, stems, flowers, bark, seeds or fruits of this plant, the whole plant etc. are used as raw materials for this extract Can be used.
Axcopaque extract is an extract from Axcopaque (Gautheria acuminata), a medicinal herb belonging to the genus Shiratamaki, and extracts leaves, stems, flowers, bark, seeds or fruits of this plant, whole plants, etc. It can be used as a raw material.

The hop extract is an extract from a female flower spike belonging to the genus Flumus, and it is possible to use leaves, stems, flowers, bark, seeds or fruits of this plant, whole plants, etc. as raw materials for this extract. is there.
The amount of the tyrosinase activity promoter should be appropriately selected according to the dosage form and form of the composition for scalp and hair, the extract concentration, etc., and is not particularly limited. It is 0.00001-10.0 mass% with respect to it, Preferably it is 0.0005-5.0 mass%. If the amount is less than 0.00001% by mass, the desired effect of preventing white hair cannot be sufficiently exhibited. If the amount exceeds 10.0% by mass, a problem in preparation may occur. In addition, said compounding quantity is the mass% as a dried solid or extract after removing an extraction solvent.

<Local stimulant>
Examples of the local stimulant used in the present invention include cantalis tincture, ginger tincture, carrot extract, red pepper tincture, menthol, camphor and nonyl acid vanillylamide. One or two or more local stimulants can be used.
Cantalis tincture is a tincture obtained by extracting a dried bean hamby with ethanol. Cantalis tincture is also known to have skin irritation, hair root irritation, scalp irritation and the like, and is already on the market (for example, Kaei Kogyo, Shiseido Pharmaceutical, etc.).
Showa tincture is a tincture obtained by extracting dried dessert with ethanol or water / ethanol. It is also marketed (for example, Ogi Pharmaceutical).

  Carrot extract is, for example, hot water or water; lower alcohols such as ethanol, isopropyl alcohol and n-butanol; polyhydric alcohols such as propylene glycol and 1,3-butylene glycol; hydrates of these alcohols; n-hexane It can be obtained by extracting dry carrot with a hydrocarbon solvent such as toluene. When a lower alcohol such as ethanol is used as an extraction solvent, the obtained extract can be blended as it is in the composition for scalp and hair of the present invention. However, the extraction solvent is once distilled off and dried if necessary. Is also possible.

Pepper tincture is a tincture obtained by extracting the pepper fruit with ethanol. It is also commercially available (for example, Alps Pharmaceutical Co., Ltd.).
Menthol is an alcohol belonging to a monocyclic monoterpene and is known to have a calming sedative action, and has eight optically active substances and four inactive substances. l-Menthol is the main component in mint oil, but all can be obtained by synthesis. These menthols are already on the market (for example, Takasago International Corporation). In this scalp and scalp hair composition, l-menthol obtained from mint oil and commercially available l-menthol synthesized by a known method are used. , Dl-menthol and the like can be blended.

  Camphor is one of the bicyclic monoterpene ketones and is known to have local stimulating action, central stimulating action, antiseptic action and the like. Camphor includes d-camphor, l-camphor and dl-camphor, although d-camphor and dl-camphor are commonly used. d-Camphor is contained in camphor or the like and obtained by steam distillation of the piece of material, and dl-camphor is obtained by a known method, for example, synthesis from pinene. These camphors are already commercially available (for example, Nippon Seika Co., Ltd., Koshiro Pharmaceutical Co., Ltd., Nippon Terpene Chemical Co., Ltd., etc.), and in the composition for scalp and hair of the present invention, they were obtained from pieces such as camphor. Any of d-camphor, dl-camphor synthesized by a known method, and commercially available d-camphor and dl-camphor can be used.

Nonyl acid vanillylamide is a compound having a structure shown in the following chemical formula 2, and is a white to white-white crystalline powder having a slightly specific odor. It has skin irritation and peripheral vasodilatory effects and is known to be used as an external preparation for myalgia, neuritis, sciatica, and the like. Although the manufacturing method of nonyl acid vanillylamide is not publicly known, it is commercially available (for example, Matsumoto Kosho Co., Ltd.).

The compounding amount of the local stimulant should be appropriately selected according to the dosage form and form of the composition for scalp and hair, and is not particularly limited, but is 0.00001 to the total amount of the composition. If it is 5.0 mass%, it is preferable and it is especially preferable that it is 0.01-5.0 mass%. If it is less than 0.00001% by mass, the desired effect of preventing white hair is not sufficiently exhibited. Moreover, when it exceeds 5.0 mass%, it is unpreferable on a formulation, and an unpleasant irritation feeling may be given to a scalp, or a hormonal action may be shown. In addition, when a local stimulant is a solvent extract of a plant, it is mass% as an extract after removing the dried solid or the extract solvent.
In the composition for scalp and hair of the present invention, in addition to the above essential components, a general base component and a medicinal component that can be blended in a normal skin composition or hair cosmetic, Depending on the form, it can be blended as long as the desired effect in the dosage form and form is not impaired. Specific ingredients that can be blended are listed below. The scalp hair composition of the present invention can be prepared by blending the above essential ingredients and one or more of the following ingredients.

  Examples of the powder component include inorganic powders (for example, talc, kaolin, mica, sericite, muscovite, phlogopite, synthetic mica, saucite, biotite, permiculite, magnesium carbonate, calcium carbonate, silicic acid. Aluminum, barium silicate, calcium silicate, magnesium silicate, strontium silicate, metal tungstate, magnesium, silica, zeolite, barium sulfate, calcined calcium sulfate (baked gypsum), calcium phosphate, fluorine apatite, hydroxyapatite, ceramic powder , Metal soap (eg, zinc myristate, calcium palmitate, aluminum stearate), boron nitride, etc .; organic powder (eg, polyamide resin powder (nylon powder), polyethylene powder, polymethyl methacrylate powder, polystyrene Powder, copolymer resin powder of styrene and acrylic acid, benzoguanamine resin powder, polytetrafluoroethylene powder, cellulose powder, etc.); inorganic white pigment (eg, titanium dioxide, zinc oxide, etc.); inorganic red pigment (eg, Iron oxide (Bengara), iron titanate, etc .; Inorganic brown pigments (eg, γ-iron oxide, etc.); Inorganic yellow pigments (eg, yellow iron oxide, loess, etc.); Inorganic black pigments (eg, black oxide) Iron, low-order titanium oxide, etc.); inorganic purple pigments (eg, mango violet, cobalt violet, etc.); inorganic green pigments (eg, chromium oxide, chromium hydroxide, cobalt titanate, etc.); inorganic blue pigments (eg, Pearl pigments (eg titanium oxide coated mica, titanium oxide coated bismuth oxychloride, titanium oxide coated talc, colored oxidation) Tan-coated mica, bismuth oxychloride, fish scale foil, etc.); metal powder pigments (eg, aluminum powder, copper powder, etc.); organic pigments such as zirconium, barium or aluminum lake (eg, red 201, red 202, red 204) No., red 205, red 220, red 226, red 228, red 405, orange 203, orange 204, yellow 205, yellow 401, and blue 404, organic pigments such as red 3 , Red 104, Red 106, Red 227, Red 230, Red 401, Red 505, Orange 205, Yellow 4, Yellow 5, Yellow 202, Yellow 203, Green 3 and Blue No. 1 etc.); natural pigments (for example, chlorophyll, β-carotene, etc.) and the like.

Examples of liquid oils include avocado oil, camellia oil, turtle oil, macadamia nut oil, corn oil, mink oil, olive oil, rapeseed oil, egg yolk oil, sesame oil, persic oil, wheat germ oil, southern castor oil, castor oil, linseed oil , Safflower oil, cottonseed oil, eno oil, soybean oil, peanut oil, tea seed oil, kaya oil, rice bran oil, cinnagiri oil, Japanese kiri oil, jojoba oil, germ oil, triglycerin and the like.
Examples of the solid fat include cacao butter, palm oil, horse fat, hydrogenated palm oil, palm oil, beef tallow, sheep fat, hydrogenated beef tallow, palm kernel oil, pork fat, beef bone fat, owl kernel oil, hydrogenated oil, cattle Leg fats, moles, hydrogenated castor oil and the like.

Examples of waxes include beeswax, candelilla wax, cotton wax, carnauba wax, bayberry wax, ibota wax, whale wax, montan wax, nuka wax, lanolin, kapok wax, lanolin acetate, liquid lanolin, sugar cane wax, lanolin fatty acid isopropyl, hexyl laurate, and reduced lanolin. , Jojoballow, hard lanolin, shellac wax, POE lanolin alcohol ether, POE lanolin alcohol acetate, POE cholesterol ether, lanolin fatty acid polyethylene glycol, POE hydrogenated lanolin alcohol ether, and the like.
Examples of the hydrocarbon oil include liquid paraffin, ozokerite, squalane, pristane, paraffin, ceresin, squalene, petrolatum, microcrystalline wax, and the like.

Examples of higher fatty acids include lauric acid, myristic acid, palmitic acid, stearic acid, behenic acid, oleic acid, undecylenic acid, toluic acid, isostearic acid, linoleic acid, linolenic acid, eicosapentaenoic acid (EPA), docosahexaenoic acid ( DHA) and the like.
Examples of higher alcohols include linear alcohols (eg, lauryl alcohol, cetyl alcohol, stearyl alcohol, behenyl alcohol, myristyl alcohol, oleyl alcohol, cetostearyl alcohol); branched chain alcohols (eg, monostearyl glycerin ether (batyl alcohol) ), 2-decyltetradecinol, lanolin alcohol, cholesterol, phytosterol, hexyl decanol, isostearyl alcohol, octyldodecanol and the like.

  Synthetic ester oils include isopropyl myristate, cetyl octanoate, octyldodecyl myristate, isopropyl palmitate, butyl stearate, hexyl laurate, myristyl myristate, decyl oleate, hexyl decyl dimethyloctanoate, cetyl lactate, myristyl lactate Lanolin acetate, isocetyl stearate, isocetyl isostearate, cholesteryl 12-hydroxystearate, ethylene glycol di-2-ethylhexanoate, dipentaerythritol fatty acid ester, monoisostearate N-alkyl glycol, neopentyl glycol dicaprate, apple Acid diisostearyl, di-2-heptylundecanoic acid glycerin, tri-2-ethylhexanoic acid trimethylolpropane, triisostearic acid trimethylo Propane, tetra-2-ethylhexanoate pentaerythritol, glycerol tri-2-ethylhexanoate, glycerol trioctanoate, glycerol triisopalmitate, trimethylolpropane triisostearate, cetyl 2-ethylhexanoate, 2-ethylhexyl palmi Tate, glyceryl trimyristate, glyceride tri-2-heptylundecanoate, castor oil fatty acid methyl ester, oleyl oleate, acetoglyceride, 2-heptylundecyl palmitate, diisobutyl adipate, N-lauroyl-L-glutamic acid-2 -Octyldodecyl ester, di-2-heptylundecyl adipate, ethyl laurate, di-2-ethylhexyl sebacate, 2-hexyldecyl myristate, 2-hexyldecyl palmitate, 2-hexyldecyl adipate Le, diisopropyl sebacate, 2-ethylhexyl succinate, and triethyl citrate.

  Examples of the silicone oil include linear polysiloxanes (for example, dimethylpolysiloxane, methylphenylpolysiloxane, diphenylpolysiloxane, etc.); cyclic polysiloxanes (for example, octamethylcyclotetrasiloxane, decamethylcyclopentasiloxane, dodecamethylcyclohexyl). Silicone resins, silicone rubber, various modified polysiloxanes (amino-modified polysiloxane, polyether-modified polysiloxane, alkyl-modified polysiloxane, fluorine-modified polysiloxane, etc.), acrylic silicone And the like.

  Anionic surfactants include, for example, fatty acid soaps (eg, sodium laurate, sodium palmitate, etc.); higher alkyl sulfates (eg, sodium lauryl sulfate, potassium lauryl sulfate, etc.); alkyl ether sulfates (eg, POE-lauryl sulfate triethanolamine, POE-sodium lauryl sulfate, etc.); N-acyl sarcosine acids (eg, sodium lauroyl sarcosine, etc.); higher fatty acid amide sulfonates (eg, sodium N-myristoyl-N-methyl taurate, palm Oil fatty acid methyl tauride sodium, lauryl methyl tauride sodium, etc .; phosphate ester salt (POE-oleyl ether sodium phosphate, POE-stearyl ether phosphate, etc.); sulfosuccinate (eg, di-2-ethylhexyl sulfo) Sodium succinate, sodium monolauroyl monoethanolamide polyoxyethylene sodium sulfosuccinate, sodium lauryl polypropylene glycol sulfosuccinate, etc.); alkyl benzene sulfonates (eg, sodium linear dodecyl benzene sulfonate, triethanol amine linear dodecyl benzene sulfonate, linear dodecyl) Higher fatty acid ester sulfates (eg, hydrogenated coconut oil fatty acid sodium glycerol sulfate); N-acyl glutamate (eg, monosodium N-lauroyl glutamate, disodium N-stearoyl glutamate, N-myristoyl) -L-glutamic acid monosodium, etc.); sulfated oil (eg funnel oil); POE-alkyl ether carboxylic acid; POE-alkyl allyl ether Α-olefin sulfonates; higher fatty acid ester sulfonates; secondary alcohol sulfates; higher fatty acid alkylolamide sulfates; lauroyl monoethanolamide sodium succinate; N-palmitoyl aspartate ditriethanolamine ; Sodium caseinate and the like.

  Examples of the cationic surfactant include alkyltrimethylammonium salts (eg, stearyltrimethylammonium chloride, lauryltrimethylammonium chloride, etc.); alkylpyridinium salts (eg, cetylpyridinium chloride, etc.); distearyldimethylammonium dialkyldimethylammonium chloride; Poly (N, N'-dimethyl-3,5-methylenepiperidinium chloride); alkyl quaternary ammonium salt; alkyldimethylbenzylammonium salt; alkylisoquinolinium salt; dialkyl morpholinium salt; POE-alkylamine; Examples include alkylamine salts; polyamine fatty acid derivatives; amyl alcohol fatty acid derivatives; benzalkonium chloride; benzethonium chloride and the like.

  Examples of amphoteric surfactants include imidazoline-based amphoteric surfactants (eg, 2-undecyl-N, N, N- (hydroxyethylcarboxymethyl) -2-imidazoline sodium, 2-cocoyl-2-imidazolinium hydroxide). Side-1-carboxyethyloxy disodium salt, etc.); betaine surfactants (for example, 2-heptadecyl-N-carboxymethyl-N-hydroxyethylimidazolinium betaine, lauryldimethylaminoacetic acid betaine, alkylbetaine, amide betaine) , Sulfobetaine, etc.).

  Examples of the lipophilic nonionic surfactant include sorbitan fatty acid esters (for example, sorbitan monooleate, sorbitan monoisostearate, sorbitan monolaurate, sorbitan monopalmitate, sorbitan monostearate, sorbitan sesquioleate, Sorbitan trioleate, diglycerol sorbitan penta-2-ethylhexylate, diglycerol sorbitan tetra-2-ethylhexylate); glycerin polyglycerin fatty acids (eg mono cottonseed oil fatty acid glycerin, glyceryl monoerucate, glyceryl sesquioleate, monostearin) Glycerin acid, α, α'-oleic acid pyroglutamate glycerin, monostearic acid glycerin malic acid, etc.); propylene glycol fatty acid esters (eg monostearies) Propylene glycolate, etc.); hardened castor oil derivative; glycerin alkyl ether, etc.

  Examples of hydrophilic nonionic surfactants include POE-sorbitan fatty acid esters (for example, POE-sorbitan monooleate, POE-sorbitan monostearate, POE-sorbitan monooleate, POE-sorbitan tetraoleate). POE sorbite fatty acid esters (eg, POE-sorbite monolaurate, POE-sorbite monooleate, POE-sorbite pentaoleate, POE-sorbite monostearate, etc.); POE-glycerin fatty acid esters (eg, POE- POE-monooleate such as glycerol monostearate, POE-glycerol monoisostearate, POE-glycerol triisostearate); POE-fatty acid esters (eg POE-distearate, POE-monodiolate, ethylene glycol distearate, etc.) POE-alkyl ethers (eg POE- Lauryl ether, POE-oleyl ether, POE-stearyl ether, POE-behenyl ether, POE-2-octyldodecyl ether, POE-cholestanol ether, etc.); Pluronic type (eg, Pluronic, etc.); POE / POP-alkyl ether (For example, POE / POP-cetyl ether, POE / POP-2-decyltetradecyl ether, POE / POP-monobutyl ether, POE / POP-hydrogenated lanolin, POE / POP-glycerin ether, etc.); Tetra POE / Tetra POP-ethylenediamine condensates (eg Tetronic, etc.); POE-castor oil hardened castor oil derivatives (eg POE-castor oil, POE-hardened castor oil, POE-hardened castor oil monoisostearate, POE-hardened castor Oil triisostearate, POE-hardened castor oil monopyroglutamic acid monoisostearic acid diester, POE-hardened castor oil maleic acid, etc.) POE-beeswax lanolin derivatives (eg POE-sorbite beeswax); alkanolamides (eg coconut oil fatty acid diethanolamide, lauric acid monoethanolamide, fatty acid isopropanolamide, etc.); POE-propylene glycol fatty acid ester; POE-alkylamine POE-fatty acid amide; sucrose fatty acid ester; alkyl ethoxydimethylamine oxide; trioleyl phosphate and the like.

  Examples of natural water-soluble polymers include plant-based polymers (for example, gum arabic, gum tragacanth, galactan, guar gum, carob gum, caraya gum, carrageenan, pectin, agar, quince seed (malmello), alge colloid (guckweed extract), starch (Rice, corn, potato, wheat), glycyrrhizic acid); microbial polymers (eg, xanthan gum, dextran, succinoglucan, bullulan, etc.); animal polymers (eg, collagen, casein, albumin, gelatin, etc.), etc. Is mentioned.

  Semi-synthetic water-soluble polymers include, for example, starch polymers (eg, carboxymethyl starch, methylhydroxypropyl starch, etc.); cellulose polymers (methylcellulose, ethylcellulose, methylhydroxypropylcellulose, hydroxyethylcellulose, sodium cellulose sulfate) Hydroxypropylcellulose, carboxymethylcellulose, sodium carboxymethylcellulose, crystalline cellulose, cellulose powder and the like); alginic acid polymers (for example, sodium alginate, propylene glycol alginate, etc.) and the like.

  Synthetic water-soluble polymers include, for example, vinyl polymers (eg, polyvinyl alcohol, polyvinyl methyl ether, polyvinyl pyrrolidone, carboxyvinyl polymer); polyoxyethylene polymers (eg, polyethylene glycol 20,000, 40,000, 60,000). Polyoxyethylene polyoxypropylene copolymer, etc.); acrylic polymers (for example, sodium polyacrylate, polyethyl acrylate, polyacrylamide, etc.); polyethyleneimine; cationic polymers, and the like.

  Examples of thickeners include gum arabic, carrageenan, caraya gum, gum tragacanth, carob gum, quince seed (malmello), casein, dextrin, gelatin, sodium pectate, sodium alginate, methylcellulose, ethylcellulose, CMC, hydroxyethylcellulose, hydroxypropyl Cellulose, PVA, PVM, PVP, sodium polyacrylate, carboxyvinyl polymer, locust bean gum, guar gum, tamarind gum, cellulose dialkyldimethylammonium sulfate, xanthan gum, magnesium aluminum silicate, bentonite, hectorite, silicate A1Mg (vee gum), Examples thereof include laponite and silicic anhydride.

  Examples of UV absorbers include benzoic acid UV absorbers (eg, paraaminobenzoic acid (hereinafter abbreviated as PABA), PABA monoglycerin ester, N, N-dipropoxy PABA ethyl ester, N, N-diethoxy PABA ethyl ester. N, N-dimethyl PABA ethyl ester, N, N-dimethyl PABA butyl ester, N, N-dimethyl PABA ethyl ester, etc.); anthranilic acid-based UV absorbers (for example, homomenthyl-N-acetyl anthranilate, etc.); Salicylic acid ultraviolet absorbers (for example, amyl salicylate, menthyl salicylate, homomenthyl salicylate, octyl salicylate, phenyl salicylate, benzyl salicylate, p-isopropanol phenyl salicylate, etc.); cinnamic acid ultraviolet absorbers (for example, octylcinnamate, ethyl- 4-isopropyl cinnamate, meth -2,5-diisopropylcinnamate, ethyl-2,4-diisopropylcinnamate, methyl-2,4-diisopropylcinnamate, propyl-p-methoxycinnamate, isopropyl-p-methoxycinnamate, isoamyl-p-methoxy Cinnamate, octyl-p-methoxycinnamate (2-ethylhexyl-p-methoxycinnamate), 2-ethoxyethyl-p-methoxycinnamate, cyclohexyl-p-methoxycinnamate, ethyl-α-cyano-β-phenyl Cinnamate, 2-ethylhexyl-α-cyano-β-phenylcinnamate, glyceryl mono-2-ethylhexanoyl-diparamethoxycinnamate, etc.); benzophenone UV absorbers (for example, 2,4-dihydroxybenzophenone, 2 , 2'-Dihydroxy-4-methoxybenzophenone, 2,2'-dihydroxy-4,4'-dimethoxybenzophenone 2,2 ', 4,4'-tetrahydroxybenzophenone, 2-hydroxy-4-methoxybenzophenone, 2-hydroxy-4-methoxy-4'-methylbenzophenone, 2-hydroxy-4-methoxybenzophenone-5-sulfone Acid salt, 4-phenylbenzophenone, 2-ethylhexyl-4′-phenyl-benzophenone-2-carboxylate, 2-hydroxy-4-n-octoxybenzophenone, 4-hydroxy-3-carboxybenzophenone, etc.); 3- ( 4'-methylbenzylidene) -d, l-camphor, 3-benzylidene-d, l-camphor; 2-phenyl-5-methylbenzoxazole; 2,2'-hydroxy-5-methylphenylbenzotriazole; (2'-hydroxy-5'-t-octylphenyl) benzotriazole; 2- (2'-hydroxy-5'-methylphenylbenzotriazole; dibenzalazine; dianisoylmethane; 4-methoxy-4'-t-butyldiben Irumetan; 5- (3,3-dimethyl-2-norbornylidene) -3-pentan-2-one, and the like.

  Examples of the lower alcohol include ethanol, propanol, isopropanol, isobutyl alcohol, t-butyl alcohol and the like.

  Examples of the polyhydric alcohol include divalent alcohols (for example, ethylene glycol, propylene glycol, trimethylene glycol, 1,2-butylene glycol, 1,3-butylene glycol, tetramethylene glycol, 2,3-butylene glycol, Pentamethylene glycol, 2-butene-1,4-diol, hexylene glycol, octylene glycol, etc.); trivalent alcohol (eg, glycerin, trimethylolpropane, etc.); tetravalent alcohol (eg, 1,2,6) Pentaerythritol such as hexanetriol); pentahydric alcohol (eg, xylitol, etc.); hexavalent alcohol (eg, sorbitol, mannitol, etc.); polyhydric alcohol polymer (eg, diethylene glycol, dipropylene glycol, triethylene glycol, polypropylene Glycol, tetraethylene glycol, diglycerin, polyethylene glycol, triglycerin, tetraglycerin, polyglycerin, etc.); divalent alcohol alkyl ethers (for example, ethylene glycol monomethyl ether, ethylene glycol monoethyl ether, ethylene glycol monobutyl ether, ethylene) Glycol monophenyl ether, ethylene glycol monohexyl ether, ethylene glycol mono 2-methylhexyl ether, ethylene glycol isoamyl ether, ethylene glycol benzyl ether, ethylene glycol isopropyl ether, ethylene glycol dimethyl ether, ethylene glycol diethyl ether, ethylene glycol dibutyl ether, etc.) ; Dihydric alcohol alkyl ester Tellurium (for example, diethylene glycol monomethyl ether, diethylene glycol monoethyl ether, diethylene glycol monobutyl ether, diethylene glycol dimethyl ether, diethylene glycol diethyl ether, diethylene glycol butyl ether, diethylene glycol methyl ethyl ether, triethylene glycol monomethyl ether, triethylene glycol monoethyl ether, propylene glycol monomethyl ether , Propylene glycol monoethyl ether, propylene glycol monobutyl ether, propylene glycol isopropyl ether, dipropylene glycol methyl ether, dipropylene glycol ethyl ether, dipropylene glycol butyl ether, etc.); divalent alcohol Ether esters (eg, ethylene glycol monomethyl ether acetate, ethylene glycol monoethyl ether acetate, ethylene glycol monobutyl ether acetate, ethylene glycol monophenyl ether acetate, ethylene glycol diazinate, ethylene glycol disuccinate, diethylene glycol monoethyl ether acetate, diethylene glycol) Monobutyl ether acetate, propylene glycol monomethyl ether acetate, propylene glycol monoethyl ether acetate, propylene glycol monopropyl ether acetate, propylene glycol monophenyl ether acetate, etc .; glycerin monoalkyl ether (for example, xyl alcohol, ceralkyl alcohol) Sugar alcohol (for example, sorbitol, maltitol, maltotriose, mannitol, sucrose, erythritol, glucose, fructose, amylolytic sugar, maltose, xylitolose, amylolytic sugar reducing alcohol, etc.); Solid; Tetrahydrofurfuryl alcohol; POE-Tetrahydrofurfuryl alcohol; POP-Butyl ether; POP / POE-Butyl ether; Tripolyoxypropylene glycerin ether; POP-glycerin ether; POP-glycerin ether phosphate; POP / POE-pentane erythritol Examples include ether and polyglycerin.

  Monosaccharides include, for example, tricarbon sugars (eg, D-glyceryl aldehyde, dihydroxyacetone, etc.); tetracarbon sugars (eg, D-erythrose, D-erythrulose, D-treose, erythritol, etc.); , L-arabinose, D-xylose, L-lyxose, D-arabinose, D-ribose, D-ribulose, D-xylulose, L-xylulose, etc .; hexose (eg, D-glucose, D-talose, D) -Bucicose, D-galactose, D-fructose, L-galactose, L-mannose, D-tagatose, etc.); pentose sugar (eg, aldheptose, heproose, etc.); octose sugar (eg, octulose, etc.); For example, 2-deoxy-D-ribose, 6-deoxy-L-galactose, 6-deoxy-L-mannose, etc .; amino sugar (eg, D-glucosamine, D-galactosamine, shea Acid, Aminouron acid, muramic acid); uronic acid (e.g., D- glucuronic acid, D- mannuronic acid, L- guluronic acid, D- galacturonic acid, L- iduronic acid) and the like.

  Examples of the oligosaccharides include sucrose, gnocyanose, umbelliferose, lactose, planteose, isoliquinoses, α, α-trehalose, raffinose, lycnose, umbilicin, stachyose verbus course and the like.

Examples of amino acids include neutral amino acids (eg, threonine, cysteine, etc.); basic amino acids (eg, hydroxylysine, etc.) and the like. Examples of amino acid derivatives include acyl sarcosine sodium (lauroyl sarcosine sodium), acyl glutamate, acyl β-alanine sodium, glutathione, and pyrrolidone carboxylic acid.
Examples of the organic amine include monoethanolamine, diethanolamine, triethanolamine, morpholine, triisopropanolamine, 2-amino-2-methyl-1,3-propanediol, and 2-amino-2-methyl-1-propanol. Is mentioned.

Examples of the sequestering agent include 1-hydroxyethane-1,1-diphosphonic acid, 1-hydroxyethane-1,1-diphosphonic acid tetrasodium salt, disodium edetate, trisodium edetate, tetrasodium edetate Sodium citrate, sodium polyphosphate, sodium metaphosphate, gluconic acid, phosphoric acid, citric acid, ascorbic acid, succinic acid, edetic acid, trisodium ethylenediaminehydroxyethyl triacetate and the like.
Examples of the antioxidant auxiliary agent include ascorbic acid, hexametaphosphate, phytic acid, ethylenediaminetetraacetic acid, vitamin E, docosahexaenoic acid, and the like.

  Other components that can be blended include, for example, preservatives (ethyl paraben, butyl paraben, etc.); anti-inflammatory agents (eg, glycyrrhizic acid derivatives, glycyrrhetinic acid derivatives, salicylic acid derivatives, hinokitiol, zinc oxide, allantoin, etc.); whitening agents (for example, Extract, placenta extract, saxifrage extract, arbutin, etc.); various extracts (eg, buckwheat, auren, sicon, birch, sage, loquat, aloe, mallow, iris, grape, yokuinin, loofah, lily, saffron, senkyu, show Cucumber, hypericum, onionis, garlic, chimpi, toki, button, seaweed, etc.), activator (for example, panthenyl ethyl ether, nicotinamide, biotin, pantothenic acid, royal jelly, photosensitizer, cholesterol derivative, etc.); anti-inflammatory agent (For example, tiger Kisamu acid, thiotaurine, and a hypotaurine and the like) and the like.

The dosage form of the scalp scalp hair composition of the present invention may be any form as long as it can be applied to the skin or scalp such as a liquid, emulsion, ointment, etc., and in general, lotion, cream, oil, gel, hair tonic , Hair liquid, treatment, aerosol mousse, aerosol spray and so on.
The scalp scalp hair composition of the present invention is generally administered by transdermal administration such as direct application or spraying to the skin. The dose should be appropriately determined according to individual differences such as age and degree of gray hair, and the dosage form and form thereof. The dose for general adults is preferably 25 to 150 mg / kg body weight, preferably Is 50-100 mg / day, which can be administered once a day or divided into 2-4 times.

EXAMPLES Next, the present invention will be described more specifically with reference to examples, but the present invention is not limited thereto. In addition, a compounding quantity is shown by the mass%.
<Synthesis Example 1 Synthesis of Block Polymer>
Polyoxyethylene (10 mol) Polyoxypropylene (10 mol) Dimethyl ether CH ₃ O (EO) ₅ (PO) ₁₀ (EO) ₅ CH ₃
76 g of propylene glycol and 3.1 g of potassium hydroxide as a catalyst were charged into an autoclave. After the air in the autoclave was replaced with dry nitrogen, the catalyst was completely dissolved at 140 ° C. with stirring. Next, 522 g of propylene oxide was dropped with a dropping device and stirred for 2 hours. Subsequently, 440 g of ethylene oxide was dropped with a dropping device and stirred for 2 hours. Next, 224 g of potassium hydroxide was charged and the inside of the system was replaced with dry nitrogen, and then 188 g of methyl chloride was injected at a temperature of 80 to 130 ° C. and reacted for 5 hours. Thereafter, the reaction composition was taken out from the autoclave, neutralized with hydrochloric acid to pH 6 to 7, and treated at a reduced pressure of -0.095 MPa (50 mmHg) at 100 ° C for 1 hour in order to remove the contained water. Further, filtration was performed to remove the salt generated after the treatment, and the alkylene oxide derivative (block polymer) was obtained.

  Samples that were sampled and reacted before reacting with methyl chloride had a hydroxyl value of 110, the resulting compound had a hydroxyl value of 0.3, and the ratio of the number of hydrogen atoms to the number of terminal methyl groups was 0.003, indicating that hydrogen was almost completely removed. An atom is converted to a methyl group.

<Synthesis Example 2 Random Polymer Synthesis Example>
Polyoxyethylene (10 mol) Polyoxypropylene (10 mol) Dimethyl ether CH ₃ O [(EO) ₁₀ / (PO) ₁₀ ] CH ₃
76 g of propylene glycol and 3.1 g of potassium hydroxide as a catalyst were charged into an autoclave. After the air in the autoclave was replaced with dry nitrogen, the catalyst was completely dissolved at 140 ° C. with stirring. Next, a mixture of 440 g of ethylene oxide and 522 g of propylene oxide was dropped with a dropping device and stirred for 2 hours. Next, 224 g of potassium hydroxide was charged and the inside of the system was replaced with dry nitrogen, and then 188 g of methyl chloride was injected at a temperature of 80 to 130 ° C. and reacted for 5 hours. Thereafter, the reaction composition was taken out from the autoclave, neutralized with hydrochloric acid to pH 6 to 7, and treated at a reduced pressure of -0.095 MPa (50 mmHg) at 100 ° C for 1 hour in order to remove the contained water. Further, filtration was performed to remove the salt generated after the treatment, and the alkylene oxide derivative (random polymer) was obtained.
Samples that were sampled and reacted before reacting with methyl chloride had a hydroxyl value of 107, the resulting compound had a hydroxyl value of 0.4, and the ratio of the number of hydrogen atoms to the number of terminal methyl groups was 0.004. An atom is converted to a methyl group.

The measurement method and evaluation criteria employed in the present invention will be described.
A panel of 10 males and females aged 40-60 years with gray hair for each sample. 2-4 ml each day (morning and evening) for 4 consecutive months. Each was applied.
“Evaluation (1): Prevention and suppression of gray hair”
The number of white hairs per 1000 hairs on the right and left parietal areas before the start of application and 4 months after the start of application was measured and compared.
<Evaluation criteria>
++++ There are 5 or more panelists whose number of gray hairs after application is less than 70% with respect to the number of gray hairs before application start. (Very effective)
++: 5 or more panelists with less than 80% of gray hair after application relative to the number of gray hair before application start. (Great effect)
+: 5 or more panelists whose number of gray hairs after application is less than 90% with respect to the number of white hairs before application start. (Effectiveness)
±: 5 or more panelists whose number of gray hairs after application is less than 100% with respect to the number of gray hairs before application start. (Slightly effective)
-: Less than 5 panelists whose number of gray hairs after application is less than 100% with respect to the number of white hairs before the start of application. (Disabled)

"Evaluation (2): Irritation"
The presence or absence of irritation of the scalp at the time of application was evaluated.
<Evaluation criteria>
◎… 8 or more panelists recognized that there was no irritation on the scalp.
○… 6 or more and less than 8 panelists recognized that the scalp was not irritating.
Δ: 3 or more and less than 6 panelists recognized that the scalp was not irritated.
X: Less than 3 panelists recognized that the scalp was not irritating.

"Evaluation (3): Moist feeling"
The presence or absence of moisture on the scalp after application was evaluated.
<Evaluation criteria>
◎… 8 or more panelists recognized that the scalp had a moist feeling.
○… 6 or more and less than 8 panelists recognized that the scalp had a moist feeling.
Δ: 3 or more and less than 6 panelists recognized that the scalp had a moist feeling.
X: Less than 3 panelists recognized that the scalp had a moist feeling.

"Evaluation (4): No stickiness"
The presence or absence of stickiness on the scalp at the time of application was evaluated.
<Evaluation criteria>
◎… 8 or more panelists recognized that the scalp was not sticky.
○… 6 or more and less than 8 panelists recognized that the scalp was not sticky.
Δ: 3 or more and less than 6 panelists recognized that the scalp was not sticky.
X: Less than 3 panelists recognized that the scalp was not sticky.

The composition for scalp hair (lotion) of the test example which consists of a compounding composition described in Table 1 was manufactured by the conventional method, and the evaluation test was done about said evaluation (1)-(4).
(Table 1)
Test example
1 2 3 4 5
95% ethanol 60 60 60 60 60
POE (14) POP (7) dimethyl ether (random polymer)
5 − − − −
Polyoxyethylene (20) glycol − 5 − − −
Polyoxypropylene (20) glycol − − 5 − −
Salamander extract 0.15 0.15 0.15 0.15 0.15
Pepper tincture 0.1 0.1 0.1 0.1 −
Perfume Appropriate amount Appropriate amount Appropriate amount Appropriate amount Appropriate amount Preservative Appropriate amount Appropriate amount Appropriate amount Appropriate amount Appropriate amount
Purified water Residue Residue Residue Residue Residue Residue
(1) Prevention and suppression of gray hair +++ +++ +++ +++ +
(2) Irritation ◎ ○ △ △ △
(3) Moist feeling ◎ ○ △ × ×
(4) No stickiness ◎ × ○ ○ ○

In Test Example 3 in which polyoxypropylene (20) glycol was blended, the moisture feeling was improved as compared to Test Example 4 in which polyoxypropylene (20) glycol was blended, but irritation was still felt. Moreover, in Test Example 2 containing polyoxyethylene (20) glycol, although improved in terms of irritation and moisture, stickiness occurred.
On the other hand, when a specific alkylene oxide derivative was blended (Test Example 1), it was particularly excellent in terms of irritation and moisture, and no sticky feeling occurred.
From the above, even when a tyrosinase activity promoter and a local stimulant are added, the scalp feels irritated so that the effect of preventing and suppressing gray hair can be sufficiently exerted by using the alkylene oxide derivative of the present invention in combination. It was revealed that a composition for scalp and hair with no moisture, a moist feeling, no stickiness, and a good feeling on use can be obtained.

<Blending amount of alkylene oxide derivative>
In order to investigate the suitable blending amount of the alkylene oxide derivative, a scalp-hair composition having the blending composition described in Table 2 was produced by a conventional method, and the above evaluations (1) to (4) were evaluated. .
(Table 2)
Test example
6 7 8 9 10 11 12 13
95% ethanol 60 60 60 60 60 60 60 60
POE (14) POP (7) dimethyl ether (random polymer)
0.01 0.5 − − 10 − − 20
POE (36) POP (41) dimethyl ether (random polymer)
− − 0.5 − − 10 − −
POE (55) POP (28) dimethyl ether (random polymer)
− − − 0.5 − − 10 −
Salamander extract 0.15 0.15 0.15 0.15 0.15 0.15 0.15 0.15
Carrot extract 0.1 0.1 0.1 0.1 0.1 0.1 0.1 0.1
Perfume Appropriate amount Appropriate amount Appropriate amount Appropriate amount Appropriate amount Appropriate amount Preservative Appropriate amount Appropriate amount Appropriate amount Appropriate amount Appropriate amount Appropriate amount Appropriate amount
Purified water residue residue residue residue residue residue residue
(1) Preventing / suppressing white hair ++ +++ +++ +++ +++ +++ +++ +++
(2) Irritation ○ ◎ ◎ ◎ ◎ ◎ ◎ ◎
(3) Moist feeling ○ ◎ ◎ ◎ ◎ ◎ ◎ ◎
(4) No stickiness ◎ ◎ ◎ ◎ ◎ ◎ ◎ ○

  From Table 2, it was confirmed that when the blending amount of the alkylene oxide derivative was in the range of 0.01 to 20% by mass, an excellent white hair prevention / suppression effect was exhibited and the usability was also good. The effect of preventing / suppressing gray hair increased depending on the blending amount of the alkylene oxide derivative, and was particularly excellent at 0.5% by mass or more. Moreover, when considering the prevention / suppression effect of white hair and the feeling of use, the blending amount of the alkylene oxide derivative is particularly preferably 0.5 to 10% by mass.

<Amount of tyrosinase activity promoter and local stimulant>
In addition, when the present inventors further examined, the compounding amount of the tyrosinase activity promoter was 0.00001 to 10.0% by mass and the compounding amount of the local stimulant was 0.00001 to 5% by mass with respect to the total amount of the composition. %, The effect of preventing / suppressing gray hair is exhibited. Particularly, the amount of the tyrosinase activity promoter is 0.0005 to 5.0% by mass, and the amount of the local stimulant is 0.01 to 5.0% by mass. In this case, a more remarkable effect was confirmed. Furthermore, in this invention, since the alkylene oxide derivative shown with general formula (I) is used together, it was confirmed that there is no irritation in these compounding ranges.

Although the formulation example of the composition for scalp and hair of this invention is given to the following, the technical scope of this invention is not limited by these. All of the obtained compositions had excellent white hair generation prevention and white hair improvement effects, and were excellent in safety and use feeling.
Formulation Example 1 Hair Tonic (Compounding ingredients)
(1) POE sorbitan monooleate (20 mol adduct) 1.0
(2) Kayurape extract 1.0
(3) 95% ethanol 50.0
(4) Tokyo tincture 0.00001
(5) POE (14) POP (7) Dimethyl ether 1.0
(6) Citric acid 0.002
(7) Sodium citrate 0.05
(8) Perfume appropriate amount
(9) Remaining amount of purified water (production method)
(1), (4), (5) and (8) were added to (3) and dissolved with stirring, and then (2), (6) and (7) were added to (9) and dissolved with stirring. Added things and got a hair tonic.

Formulation Example 2 Hair Tonic (Compounding ingredients)
(1) Propylene glycol 3.0
(2) L-Menthol 0.5
(3) Guacomist extract 5.0
(4) 95% ethanol 70.0
(5) Cantalis tincture 0.01
(6) POE (27) POP (14) Dimethyl ether 5.0
(7) Fragrance appropriate amount
(8) Remaining amount of purified water (production method)
Add (1), (2), (5), (6), (7) to (4) and dissolve with stirring, then add (3) to (8), add what is dissolved with stirring. Got a hair tonic.

Formulation Example 3 Hair Tonic (Compounding ingredients)
(1) Polyethylene glycol 2.0
(2) D-Camphor 0.3
(3) Ping squid extract 0.005
(4) 95% ethanol 40.0
(5) Polyoxyethylene hydrogenated castor oil
(10EO, 20PO adduct) 2.0
(6) Carrot extract 0.01
(7) POE (36) POP (41) dimethyl ether 3.0
(8) Perfume appropriate amount
(9) Remaining amount of purified water (production method and evaluation)
Add (1), (2), (5) to (8) to (4) and dissolve with stirring, then add (3) to (9), add the mixture with stirring, and add hair tonic. Obtained.

Formulation Example 4 Hair Liquid (Compounding ingredients)
(1) Polyoxypropyl butyl ether (40PO) 20.0
(2) Polyoxypropyl butyl ether phosphate (40PO) 5.0
(3) Aritasou extract 0.001
(4) D-Camphor 0.3
(5) Glycerin 1.0
(6) 95% ethanol 55.0
(7) Tri-2-ethylhexyl glycerin 0.5
(8) POE (55) POP (28) Dimethyl ether 1.0
(9) Perfume appropriate amount
(10) Dye proper amount
(11) Lactic acid appropriate amount
(12) Remaining amount of purified water (production method)
(1), (2), (4), (5), (7), (8), (9) are added to (6), and after stirring and dissolving, (3), (10 ) And (11) were added, and the mixture dissolved by stirring was added to obtain a hair liquid.

Formulation Example 5 Scalp Treatment (Compounding ingredients) Mass%
(1) 1,3-propylene glycol 1.5
(2) Erythritol 1.0
(3) 95% ethanol 60.0
(4) Zapote extract 1.0
(5) L-Menthol 0.6
(6) POE (7) POP (14) Dimethyl ether 2.0
(7) Fragrance appropriate amount
(8) Appropriate amount of purified water
(9) Appropriate amount of dimethyl ether
(Manufacturing method)
(1), (2), (4) to (7) were added to (3), dissolved by stirring, and then (8) was added to prepare a stock solution. The can was filled with the stock solution, and after mounting the valve (9), a scalp treatment was obtained.

Formulation Example 6 Hair Cream (Compounding ingredients)
<A phase>
(1) Liquid paraffin 8.0
(2) Cetostearyl alcohol 5.5
(3) Vaseline 5.5
(4) Glyceryl monostearate 3.0
(5) sorbitan monooleate 3.0
(6) Nonylic acid vanillylamide 0.5
(7) Tocophenol acetate 1.0
(8) Butylparaben 0.2
(9) Fragrance 0.3
<Phase B>
(10) Axcopaque extract 1.0
(11) Glycerin 5.0
(12) Dipropylene glycol 20.0
(13) Polyethylene glycol 1500 5.0
(14) POE (17) POP (4) Dimethyl ether 1.0
(15) Sodium hexametaphosphate 0.005
(16) Remaining amount of purified water (production method)
A phase A was prepared by mixing (1) to (9) and dissolving by heating. Separately, (10) to (16) were mixed and dissolved by heating to prepare Phase B. Thereafter, phase B was added to phase A and emulsified with a homomixer to obtain a hair cream.

Formulation Example 7 Hair Gel (Compounding ingredients)
(1) Carboxyvinyl polymer 0.45
(2) Xanthan gum 0.2
(3) Polyvinylpyrrolidone 3.0
(4) Sorbitol 2.0
(5) Hop extract 0.00001
(6) Sodium hydroxide appropriate amount
(7) Ethanol 15.0
(8) Appropriate amount of polyoxyethylene octyldodecyl ether
(9) L-Camphor 2.0
(10) POE (9) POP (2) Dimethyl ether 1.0
(11) Fragrance appropriate amount
(12) edetic acid appropriate amount
(13) Remaining amount of purified water (production method)
(1) to (5) and (12) were dissolved in (13). (8) to (11) were dissolved in (7). After this was added to the above parts with stirring, (6) was added to increase the viscosity to obtain a hair gel.

Formulation Example 8 Hair spray (stock solution formulation)
(1) Acrylic resin alkanolamine salt 10.0
(2) Cetanol 0.1
(3) Dodecamethylpolysiloxane 0.5
(4) Ethanol stock residue
(5) Salamander extract 0.01
(6) Perfume appropriate amount
(7) L-Menthol 0.01
(8) POE (14) POB (7) Dimethyl ether 3.0
(Filling prescription)
(9) Stock solution 60.0
(10) Dimethyl ether 35.0
(11) LPG 5.0
(Manufacturing method)
(1) to (3) and (5) to (8) were dissolved in (4) to prepare a stock solution. The can was filled with the stock solution (9), and after mounting the valve (10) and (11) were filled to obtain a hair spray.

Claims (8)

An alkylene oxide derivative represented by the following chemical formula (I):
A tyrosinase activity promoter;
A composition for scalp and hair comprising a local stimulant.
(Chemical formula 1)
_{^{R 1 O - [(AO)}} m (EO) n] -R 2 (I)
(In the formula, AO is an oxyalkylene group having 3 to 4 carbon atoms, EO is an oxyethylene group, m and n are average addition moles of the oxyalkylene group and oxyethylene group, respectively, 1 ≦ m ≦ 70, 1 ≦ n ≦ 70 The ratio of the oxyethylene group to the total of the oxyalkylene group having 3 to 4 carbon atoms and the oxyethylene group is 20 to 80 mass% The oxyalkylene group and oxyethylene group having 3 to 4 carbon atoms R ¹ and R ² may be the same or different, and may be the same or different, a C 1-4 hydrocarbon group or a hydrogen atom, and R ¹ and R ² may be added in a block form or in a random form. (The ratio of the number of hydrogen atoms to the number of hydrocarbon groups of R ² is 0.15 or less.)   The composition for scalp and hair according to claim 1, wherein the oxyalkylene group and oxyethylene group of the alkylene oxide derivative represented by the chemical formula (I) are randomly added.   The composition for scalp and hair according to claim 1 or 2, wherein 0.01 to 20% by mass of the alkylene oxide derivative represented by the chemical formula (I) is blended.   The composition according to any one of claims 1 to 3, wherein the tyrosinase activity promoter is one or more selected from the group consisting of salamander, cayurape, guacomist, pin squid, Aritasou, zapote, axcopaque, and hops. A composition for scalp and hair, wherein the composition is a solvent extract of the plant.   The composition for scalp and hair according to any one of claims 1 to 4, wherein 0.00001 to 10.0% by mass of a tyrosinase activity promoter is blended.   The composition according to any one of claims 1 to 5, wherein the local stimulant is selected from the group consisting of cantharis tincture, ginger tincture, carrot extract, red pepper tincture, menthol, camphor and nonylic acid vanillylamide or A composition for scalp and hair characterized by being two or more.   The composition for scalp and hair according to any one of claims 1 to 6, wherein 0.00001 to 5.0% by mass of a local stimulant is blended.   A composition for scalp and hair, wherein the composition according to any one of claims 1 to 7 is a cosmetic for anti-white hair.