JP2005154955A - Aqueous allergen-suppressing agent - Google Patents
Aqueous allergen-suppressing agent Download PDFInfo
- Publication number
- JP2005154955A JP2005154955A JP2003396095A JP2003396095A JP2005154955A JP 2005154955 A JP2005154955 A JP 2005154955A JP 2003396095 A JP2003396095 A JP 2003396095A JP 2003396095 A JP2003396095 A JP 2003396095A JP 2005154955 A JP2005154955 A JP 2005154955A
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- Prior art keywords
- allergen
- water
- allergen inhibitor
- aqueous
- inhibitor
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- 239000013566 allergen Substances 0.000 claims abstract description 139
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 51
- 239000007864 aqueous solution Substances 0.000 claims abstract description 17
- 239000003112 inhibitor Substances 0.000 claims description 70
- -1 aromatic hydroxy compound Chemical class 0.000 claims description 33
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims description 29
- 125000001424 substituent group Chemical group 0.000 claims description 29
- 239000000178 monomer Substances 0.000 claims description 25
- 229920000642 polymer Polymers 0.000 claims description 16
- 230000000379 polymerizing effect Effects 0.000 claims description 7
- 229910052739 hydrogen Inorganic materials 0.000 claims description 5
- 239000001257 hydrogen Substances 0.000 claims description 5
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims description 3
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 2
- 239000003795 chemical substances by application Substances 0.000 abstract description 9
- 230000000694 effects Effects 0.000 abstract description 9
- 239000000243 solution Substances 0.000 abstract description 5
- 239000011248 coating agent Substances 0.000 abstract description 4
- 238000000576 coating method Methods 0.000 abstract description 4
- 238000005507 spraying Methods 0.000 abstract description 4
- 238000004090 dissolution Methods 0.000 abstract description 3
- 230000001747 exhibiting effect Effects 0.000 abstract 1
- 229960004784 allergens Drugs 0.000 description 19
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 18
- KWYUFKZDYYNOTN-UHFFFAOYSA-M Potassium hydroxide Chemical compound [OH-].[K+] KWYUFKZDYYNOTN-UHFFFAOYSA-M 0.000 description 15
- 239000004744 fabric Substances 0.000 description 13
- 241000238876 Acari Species 0.000 description 12
- 125000006615 aromatic heterocyclic group Chemical group 0.000 description 12
- 150000001875 compounds Chemical class 0.000 description 11
- 238000000034 method Methods 0.000 description 11
- 230000002401 inhibitory effect Effects 0.000 description 10
- 238000003756 stirring Methods 0.000 description 9
- 239000000126 substance Substances 0.000 description 9
- 208000026935 allergic disease Diseases 0.000 description 7
- 238000004519 manufacturing process Methods 0.000 description 7
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- 239000001263 FEMA 3042 Substances 0.000 description 4
- BAPJBEWLBFYGME-UHFFFAOYSA-N Methyl acrylate Chemical compound COC(=O)C=C BAPJBEWLBFYGME-UHFFFAOYSA-N 0.000 description 4
- LRBQNJMCXXYXIU-PPKXGCFTSA-N Penta-digallate-beta-D-glucose Natural products OC1=C(O)C(O)=CC(C(=O)OC=2C(=C(O)C=C(C=2)C(=O)OC[C@@H]2[C@H]([C@H](OC(=O)C=3C=C(OC(=O)C=4C=C(O)C(O)=C(O)C=4)C(O)=C(O)C=3)[C@@H](OC(=O)C=3C=C(OC(=O)C=4C=C(O)C(O)=C(O)C=4)C(O)=C(O)C=3)[C@H](OC(=O)C=3C=C(OC(=O)C=4C=C(O)C(O)=C(O)C=4)C(O)=C(O)C=3)O2)OC(=O)C=2C=C(OC(=O)C=3C=C(O)C(O)=C(O)C=3)C(O)=C(O)C=2)O)=C1 LRBQNJMCXXYXIU-PPKXGCFTSA-N 0.000 description 4
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 4
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- 125000003118 aryl group Chemical group 0.000 description 4
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- 125000000623 heterocyclic group Chemical group 0.000 description 4
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- LRBQNJMCXXYXIU-NRMVVENXSA-N tannic acid Chemical compound OC1=C(O)C(O)=CC(C(=O)OC=2C(=C(O)C=C(C=2)C(=O)OC[C@@H]2[C@H]([C@H](OC(=O)C=3C=C(OC(=O)C=4C=C(O)C(O)=C(O)C=4)C(O)=C(O)C=3)[C@@H](OC(=O)C=3C=C(OC(=O)C=4C=C(O)C(O)=C(O)C=4)C(O)=C(O)C=3)[C@@H](OC(=O)C=3C=C(OC(=O)C=4C=C(O)C(O)=C(O)C=4)C(O)=C(O)C=3)O2)OC(=O)C=2C=C(OC(=O)C=3C=C(O)C(O)=C(O)C=3)C(O)=C(O)C=2)O)=C1 LRBQNJMCXXYXIU-NRMVVENXSA-N 0.000 description 4
- 229940033123 tannic acid Drugs 0.000 description 4
- 235000015523 tannic acid Nutrition 0.000 description 4
- 229920002258 tannic acid Polymers 0.000 description 4
- OUYCCCASQSFEME-QMMMGPOBSA-N L-tyrosine Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-QMMMGPOBSA-N 0.000 description 3
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- GNSFRPWPOGYVLO-UHFFFAOYSA-N 3-hydroxypropyl 2-methylprop-2-enoate Chemical compound CC(=C)C(=O)OCCCO GNSFRPWPOGYVLO-UHFFFAOYSA-N 0.000 description 2
- QZPSOSOOLFHYRR-UHFFFAOYSA-N 3-hydroxypropyl prop-2-enoate Chemical compound OCCCOC(=O)C=C QZPSOSOOLFHYRR-UHFFFAOYSA-N 0.000 description 2
- GRFNBEZIAWKNCO-UHFFFAOYSA-N 3-pyridinol Chemical compound OC1=CC=CN=C1 GRFNBEZIAWKNCO-UHFFFAOYSA-N 0.000 description 2
- NIXOWILDQLNWCW-UHFFFAOYSA-M Acrylate Chemical compound [O-]C(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-M 0.000 description 2
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- 239000005977 Ethylene Substances 0.000 description 2
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- UFWIBTONFRDIAS-UHFFFAOYSA-N Naphthalene Chemical compound C1=CC=CC2=CC=CC=C21 UFWIBTONFRDIAS-UHFFFAOYSA-N 0.000 description 2
- 239000004952 Polyamide Substances 0.000 description 2
- 229920002125 Sokalan® Polymers 0.000 description 2
- YTPLMLYBLZKORZ-UHFFFAOYSA-N Thiophene Chemical compound C=1C=CSC=1 YTPLMLYBLZKORZ-UHFFFAOYSA-N 0.000 description 2
- 229910052783 alkali metal Inorganic materials 0.000 description 2
- 125000000217 alkyl group Chemical group 0.000 description 2
- 230000000172 allergic effect Effects 0.000 description 2
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- 238000002156 mixing Methods 0.000 description 2
- ISWSIDIOOBJBQZ-UHFFFAOYSA-N phenol group Chemical group C1(=CC=CC=C1)O ISWSIDIOOBJBQZ-UHFFFAOYSA-N 0.000 description 2
- 239000004584 polyacrylic acid Substances 0.000 description 2
- 229920002647 polyamide Polymers 0.000 description 2
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- 238000006116 polymerization reaction Methods 0.000 description 2
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- NAWXUBYGYWOOIX-SFHVURJKSA-N (2s)-2-[[4-[2-(2,4-diaminoquinazolin-6-yl)ethyl]benzoyl]amino]-4-methylidenepentanedioic acid Chemical compound C1=CC2=NC(N)=NC(N)=C2C=C1CCC1=CC=C(C(=O)N[C@@H](CC(=C)C(O)=O)C(O)=O)C=C1 NAWXUBYGYWOOIX-SFHVURJKSA-N 0.000 description 1
- YHAROSAFXOQKCZ-UHFFFAOYSA-N 1-benzofuran-2-ol Chemical compound C1=CC=C2OC(O)=CC2=C1 YHAROSAFXOQKCZ-UHFFFAOYSA-N 0.000 description 1
- MLCKCPCPWBVTEB-UHFFFAOYSA-N 5-ethenylanthracen-1-ol Chemical compound C1=CC=C2C=C3C(O)=CC=CC3=CC2=C1C=C MLCKCPCPWBVTEB-UHFFFAOYSA-N 0.000 description 1
- CQQHIOVHAIIVOP-UHFFFAOYSA-N 5-ethenylnaphthalen-2-ol Chemical compound C=CC1=CC=CC2=CC(O)=CC=C21 CQQHIOVHAIIVOP-UHFFFAOYSA-N 0.000 description 1
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- 241000282472 Canis lupus familiaris Species 0.000 description 1
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 1
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- SVPXDRXYRYOSEX-UHFFFAOYSA-N bentoquatam Chemical compound O.O=[Si]=O.O=[Al]O[Al]=O SVPXDRXYRYOSEX-UHFFFAOYSA-N 0.000 description 1
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- 239000001110 calcium chloride Substances 0.000 description 1
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Landscapes
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Abstract
Description
本発明は、スギなどの草木の花粉、ダニ、室内の塵などのアレルゲンが特異抗体と反応
するのを抑制する水系アレルゲン抑制剤に関する。
The present invention relates to an aqueous allergen inhibitor that suppresses the reaction of allergens such as pollen of vegetation such as cedar, mites, and indoor dust with a specific antibody.
近年、アトピー性皮膚炎、気管支喘息、アレルギー性鼻炎などの多くのアレルギー疾患
が問題となってきている。このアレルギー疾患の主な原因としては、住居内に生息するダ
ニ類、特に、室内塵中に多く存在するヒョウダニのアレルゲン（Ｄｅｒ１、Ｄｅｒ２）や
、主に春季に多量に空気中に浮遊するスギ花粉アレルゲン（Ｃｒｉｊ１、Ｃｒｉｊ２）な
どのアレルゲンが生活空間内に増加してきているためである。
In recent years, many allergic diseases such as atopic dermatitis, bronchial asthma and allergic rhinitis have become a problem. The main causes of this allergic disease are ticks that live in the house, especially leopard mite allergens (Der1, Der2) that are abundant in house dust, and cedar pollen that floats in the air mainly in spring. This is because allergens such as allergens (Crij1, Crij2) are increasing in the living space.
そして、ヒョウダニのアレルゲンは、ヒョウダニを駆除しても、ヒョウダニの死骸がア
レルゲンとなるために、アレルギー疾患の根本的な解決にはならない。又、スギ花粉アレ
ルゲンであるＣｒｉｊ１は分子量が約４０ｋＤａの糖タンパク質であり、Ｃｒｉｊ２は分
子量が約３７ｋＤａの糖タンパク質である。そして、スギ花粉アレルゲンは、鼻粘膜など
に付着すると生体外異物として認識されて炎症反応を引き起こす。
And the allergens of leopard mites are not a fundamental solution to allergic diseases because the dead bodies of leopard mites become allergens even if they are exterminated. Moreover, Crij1 which is a cedar pollen allergen is a glycoprotein having a molecular weight of about 40 kDa, and Crij2 is a glycoprotein having a molecular weight of about 37 kDa. When the cedar pollen allergen adheres to the nasal mucosa, the cedar pollen allergen is recognized as a foreign substance and causes an inflammatory reaction.
従って、アレルギー疾患の症状を軽減し或いは新たなアレルギー症状を防止するために
は、生活空間からアレルゲンを完全に取り除くか、アレルゲンを変性させるなどして不活
性化させることが必要となる。
Therefore, in order to reduce the symptoms of allergic diseases or prevent new allergic symptoms, it is necessary to completely inactivate allergens from the living space or to inactivate allergens.
特に、カーペット、ソファ、畳、寝具などの家庭用品は、アレルギー疾患を持つ患者に
とっては最もアレルゲンの抑制が望まれているものである。その理由は次の通りである。
第一に、人が長時間に亘って接触するものであること、第二に、カーペットなどは繊維か
ら構成されていることから、繊維間の隙間にダニなどが繁殖し易いと共にその他の微小粒
子状のアレルゲンも蓄積され易いからである。
In particular, household products such as carpets, sofas, tatami mats, and bedding are most desired to suppress allergens for patients with allergic diseases. The reason is as follows.
First, because humans are in contact with each other for a long time, and secondly, carpets and the like are made of fibers. This is because the allergens in the form are also likely to accumulate.
そこで、特許文献１には、家庭用品をタンニン酸で処理してアレルゲンを除去する方法
が提案されている。しかしながら、タンニン酸は水溶性であることから、家庭用品をタン
ニン酸で処理しても、タンニン酸が洗濯や空気中の水分中に溶解して家庭用品から流れ出
てしまってアレルゲンの除去効果が持続しないといった問題点があった。
Therefore, Patent Document 1 proposes a method for removing allergens by treating household products with tannic acid. However, since tannic acid is water-soluble, even if household products are treated with tannic acid, the tannic acid dissolves in laundry and moisture in the air and flows out of the household products, so the allergen removal effect continues. There was a problem of not doing.
本発明は、水分中に溶解し流れ出て消失することがなく、アレルゲン抑制効果を長期間
に亘って発揮し得る水系アレルゲン抑制剤を提供する。
The present invention provides an aqueous allergen inhibitor that can exhibit an allergen inhibitory effect over a long period of time without dissolving in water and flowing out and disappearing.
本発明の水系アレルゲン抑制剤は、非水溶性アレルゲン抑制剤がｐＨ１２以上の水溶液
中に溶解されてなることを特徴とする。なお、本発明において「非水溶性」とは、２０℃
におけるｐＨ７の水への溶解度（１００ｇの水に溶解する物質のグラム数）が１ｇ未満で
あることをいう一方、「水溶性」とは、２０℃におけるｐＨ７の水への溶解度（１００ｇ
の水に溶解する物質のグラム数）が１ｇ以上であることをいう。
The aqueous allergen inhibitor of the present invention is characterized in that a water-insoluble allergen inhibitor is dissolved in an aqueous solution having a pH of 12 or more. In the present invention, “water-insoluble” means 20 ° C.
On the other hand, the solubility in water at pH 7 (grams of substance dissolved in 100 g of water) is less than 1 g, while “water-soluble” means the solubility in water at pH 7 at 20 ° C. (100 g
The number of grams of substance dissolved in water) is 1 g or more.
そして、上記非水溶性アレルゲン抑制剤としては、非水溶性であってアレルゲン抑制効
果を奏するものであれば、特に限定されず、例えば、後述する芳香族ヒドロキシ化合物の
他に、水溶性アレルゲン抑制剤を架橋剤などで架橋して非水溶性としたもの、水溶性アレ
ルゲン抑制剤を高分子量化して非水溶性としたもの、水溶性アレルゲン抑制剤を非水溶性
の固体担体に吸着させたり或いはグラフト重合などによって化学的に結合させて非水溶性
としたもの、水溶性アレルゲン抑制剤をバインダに結合させて非水溶性としたものなどが
挙げられ、単独で用いられても二種以上を併用してもよい。
The water-insoluble allergen inhibitor is not particularly limited as long as it is water-insoluble and exhibits an allergen-inhibiting effect. For example, in addition to the aromatic hydroxy compound described later, a water-soluble allergen inhibitor Is made water-insoluble by crosslinking with a crosslinking agent, water-soluble allergen inhibitor is made water-insoluble by high molecular weight, water-soluble allergen inhibitor is adsorbed on a water-insoluble solid carrier, or grafted Examples include those that are chemically bonded by polymerization, etc., made water-insoluble, and those that are made water-insoluble by binding a water-soluble allergen inhibitor to a binder. May be.
ここで、上記固体担体としては、例えば、タルク、ベントナイト、クレー、カオリン、
珪藻土、シリカ、バーミュライト、パーライトなどの無機系担体、ポリエチレン、ポリプ
ロピレンなどの有機系高分子担体などが挙げられる。
Here, as the solid support, for example, talc, bentonite, clay, kaolin,
Examples thereof include inorganic carriers such as diatomaceous earth, silica, vermulite and perlite, and organic polymer carriers such as polyethylene and polypropylene.
又、上記アレルゲン抑制効果とは、ヒョウヒダニのアレルゲン（Ｄｅｒ１、Ｄｅｒ２）
、空気中に浮遊するスギ花粉アレルゲン（Ｃｒｉｊ１、Ｃｒｉｊ２）、犬や猫に起因する
アレルゲン（Ｃａｎ ｆ１、Ｆｅｌ ｄ１）などのアレルゲンを変性し或いは吸着し、ア
レルゲンの特異抗体に対する反応性を抑制する効果をいう。
The allergen-inhibiting effect is that of leopard mite allergens (Der1, Der2)
Denatures or adsorbs allergens such as cedar pollen allergens (Crij1, Crij2) floating in the air and dogs and cats (Can f1, Fel d1), and suppresses allergen reactivity to specific antibodies Say.
上記アレルゲン抑制効果を確認する方法としては、例えば、アレルゲン量測定具（ＬＣ
Ｄアレルギー研究所社製 商品名「ＥＬＩＳＡキット」）を用いてＥＬＩＳＡ法に基づい
てアレルゲン量を測定する方法が挙げられる。
As a method for confirming the allergen inhibitory effect, for example, an allergen amount measuring instrument (LC
D Allergic Research Institute, Inc., trade name “ELISA kit”), and a method for measuring the amount of allergen based on the ELISA method.
次に、上記芳香族ヒドロキシ化合物について説明する。上記芳香族ヒドロキシ化合物と
しては、芳香族ヒドロキシル基を有し且つアレルゲン抑制効果を備えたものであれば、特
に限定されず、例えば、線状高分子に下記一般式（１）〜（６）で示される置換基のうち
の少なくとも一つの置換基を有する芳香族ヒドロキシ化合物などの、一般式（１）〜（６
）で示される置換基を少なくとも一つ含む単量体を重合又は共重合してなる芳香族ヒドロ
キシ化合物；芳香族複素環式ヒドロキシ化合物；線状高分子に置換基として芳香族複素環
式ヒドロキシ基を有する芳香族ヒドロキシ化合物などの、芳香族複素環式ヒドロキシ基を
有する単量体を重合又は共重合してなる芳香族ヒドロキシ化合物などが挙げられ、線状高
分子に下記一般式（１）〜（６）で示される置換基のうちの少なくとも一つの置換基を有
する芳香族ヒドロキシ化合物、線状高分子に置換基として芳香族複素環式ヒドロキシ基を
有する芳香族ヒドロキシ化合物が好ましい。
Next, the aromatic hydroxy compound will be described. The aromatic hydroxy compound is not particularly limited as long as it has an aromatic hydroxyl group and has an allergen suppressing effect. For example, linear polymers are represented by the following general formulas (1) to (6). General formulas (1) to (6) such as aromatic hydroxy compounds having at least one of the substituents shown
) An aromatic hydroxy compound obtained by polymerizing or copolymerizing a monomer containing at least one substituent represented by formula; an aromatic heterocyclic hydroxy compound; an aromatic heterocyclic hydroxy group as a substituent on a linear polymer Aromatic hydroxy compounds formed by polymerizing or copolymerizing monomers having an aromatic heterocyclic hydroxy group, such as aromatic hydroxy compounds having the following formulas, and the following general formulas (1) to (1): An aromatic hydroxy compound having at least one of the substituents represented by (6) and an aromatic hydroxy compound having an aromatic heterocyclic hydroxy group as a substituent on the linear polymer are preferred.
先ず、一般式（１）〜（６）で示される置換基を少なくとも一つ含む単量体を重合又は
共重合してなる芳香族ヒドロキシ化合物について説明する。この芳香族ヒドロキシ化合物
の置換基は、下記一般式（１）〜（６）で示される。
First, an aromatic hydroxy compound obtained by polymerizing or copolymerizing a monomer containing at least one substituent represented by the general formulas (1) to (6) will be described. The substituents of this aromatic hydroxy compound are represented by the following general formulas (1) to (6).
なお、一般式（１）〜（６）において、ｎは、０〜５の整数である。これは、ｎが６以
上となると、一般式（１）〜（６）で示される置換基が発現するアレルゲン抑制効果が不
充分となるからである。
In general formulas (1) to (6), n is an integer of 0 to 5. This is because when n is 6 or more, the allergen suppressing effect expressed by the substituents represented by the general formulas (1) to (6) becomes insufficient.
そして、置換基Ｒは、水素又は水酸基である。更に、置換基Ｒの少なくとも一つは、芳
香族ヒドロキシ化合物がアレルゲン抑制効果を発揮するために、水酸基である必要がある
。しかしながら、水酸基の数が多過ぎると、アレルゲン抑制剤を施したものが着色したり
或いは変色し易くなるため、水酸基の数は一つが好ましい。即ち、置換基Ｒのうちの一つ
のみが水酸基である一方、この置換基以外の置換基Ｒが全て水素であることが好ましい。
The substituent R is hydrogen or a hydroxyl group. Furthermore, at least one of the substituents R needs to be a hydroxyl group in order for the aromatic hydroxy compound to exhibit an allergen suppressing effect. However, if the number of hydroxyl groups is too large, the product to which the allergen inhibitor has been applied is likely to be colored or discolored, so that the number of hydroxyl groups is preferably one. That is, it is preferable that only one of the substituents R is a hydroxyl group, while all the substituents R other than this substituent are hydrogen.
更に、水酸基の位置は、立体障害の最も少ない位置に結合していることが好ましく、例
えば、一般式（１）では、水酸基がパラ位に結合していることが好ましい。
Furthermore, the position of the hydroxyl group is preferably bonded to the position having the least steric hindrance. For example, in general formula (1), the hydroxyl group is preferably bonded to the para position.
上記一般式（１）〜（６）で示される置換基を少なくとも一つ含む単量体としては、一
般式（１）〜（６）で示される置換基を有しておれば、特に限定されず、例えば、ビニル
フェノール、チロシン、１，２−ジ（４−ヒドロキシフェニル）エテン（一般式（７））
などの一価のフェノール基を有する単量体が挙げられる。
The monomer containing at least one substituent represented by the general formulas (1) to (6) is particularly limited as long as it has the substituent represented by the general formulas (1) to (6). For example, vinylphenol, tyrosine, 1,2-di (4-hydroxyphenyl) ethene (general formula (7))
And monomers having a monovalent phenol group.
更に、芳香族ヒドロキシ化合物のアレルゲン抑制効果を阻害しない範囲内において、一
般式（１）〜（６）で示される置換基を少なくとも一つ含む単量体、好ましくは、一価の
フェノール基を一個以上有する単量体に、この単量体と共重合可能な単量体を共重合させ
てもよい。
Further, a monomer containing at least one substituent represented by the general formulas (1) to (6), preferably one monovalent phenol group within a range not inhibiting the allergen suppressing effect of the aromatic hydroxy compound. A monomer copolymerizable with this monomer may be copolymerized with the monomer having the above.
このような単量体としては、例えば、エチレン、アクリレート、メタクリレート、メチ
ルアクリレート、メチルメタクリレート、ヒドロキシエチルアクリレート、ヒドロシキエ
チルメタクリレート、ヒドロキシプロピルアクリレート、ヒドロキシプロピルメタクリレ
ート、スチレンなどが挙げられる。
Examples of such monomers include ethylene, acrylate, methacrylate, methyl acrylate, methyl methacrylate, hydroxyethyl acrylate, hydroxyethyl methacrylate, hydroxypropyl acrylate, hydroxypropyl methacrylate, and styrene.
そして、一般式（１）〜（６）で示される置換基が結合している線状高分子としては、
特に限定されず、ビニル重合体、ポリエステル、ポリアミドなどが挙げられる。この線状
高分子と一般式（１）〜（６）で示される置換基との間の化学結合については、特に限定
されず、炭素−炭素結合、エステル結合、エーテル結合、アミド結合などが挙げられる。
And as a linear polymer to which the substituents represented by the general formulas (1) to (6) are bonded,
It does not specifically limit, A vinyl polymer, polyester, polyamide, etc. are mentioned. The chemical bond between the linear polymer and the substituents represented by the general formulas (1) to (6) is not particularly limited, and examples thereof include a carbon-carbon bond, an ester bond, an ether bond, and an amide bond. It is done.
ここで、線状高分子に一般式（１）〜（６）で示される置換基のうちの少なくとも一つ
の置換基を有する芳香族ヒドロキシ化合物としては、例えば、(1) 一般式（１）〜（６）
で示される置換基を少なくとも一つ含む単量体の線状重合体又は線状共重合体、(2) 一般
式（１）〜（６）で示される置換基を少なくとも一つ含む単量体と、この単量体と共重合
可能な単量体との線状共重合体などが挙げられる。
Here, examples of the aromatic hydroxy compound having at least one of the substituents represented by the general formulas (1) to (6) in the linear polymer include (1) the general formulas (1) to (1) (6)
A linear polymer or linear copolymer of a monomer containing at least one substituent represented by formula (2), a monomer containing at least one substituent represented by the general formulas (1) to (6) And a linear copolymer of the monomer and copolymerizable monomer.
そして、線状高分子に一般式（１）〜（６）で示される置換基のうちの少なくとも一つ
の置換基を有する芳香族ヒドロキシ化合物としては、具体的には、ポリ３，４，５−ヒド
ロキシ安息香酸ビニル、ポリビニルフェノール、ポリチロシン、ポリ( １−ビニル−５−
ヒドロキシナフタレン) 、ポリ( １−ビニル−６−ヒドロキシナフタレン) 、ポリ( １−
ビニル−５−ヒドロキシアントラセン) が好ましい。
Specific examples of the aromatic hydroxy compound having at least one of the substituents represented by the general formulas (1) to (6) in the linear polymer include poly 3, 4, 5- Vinyl hydroxybenzoate, polyvinylphenol, polytyrosine, poly (1-vinyl-5-
Hydroxy (naphthalene), poly (1-vinyl-6-hydroxynaphthalene), poly (1-
Vinyl-5-hydroxyanthracene) is preferred.
なお、上記単量体を重合させて得られる芳香族ヒドロキシ化合物の分子量としては、特
に限定されないが、単量体を２個以上重合させてなる芳香族ヒドロキシ化合物が好ましく
、単量体を５個以上重合させてなる芳香族ヒドロキシ化合物がより好ましい。
The molecular weight of the aromatic hydroxy compound obtained by polymerizing the monomer is not particularly limited, but is preferably an aromatic hydroxy compound obtained by polymerizing two or more monomers, and includes five monomers. An aromatic hydroxy compound obtained by polymerization as described above is more preferable.
又、上記芳香族複素環式ヒドロキシ化合物としては、アレルゲン抑制効果を奏すれば、
特に限定されず、例えば、２−ヒドロキシフラン、２−ヒドロキシチオフェン、ヒドロキ
シベンゾフラン、３−ヒドロキシピリジンなどが挙げられる。
In addition, as the aromatic heterocyclic hydroxy compound, if it has an allergen suppressing effect,
It does not specifically limit, For example, 2-hydroxyfuran, 2-hydroxythiophene, hydroxybenzofuran, 3-hydroxypyridine etc. are mentioned.
次に、線状高分子に置換基として芳香族複素環式ヒドロキシ基を有する芳香族ヒドロキ
シ化合物などの、芳香族複素環式ヒドロキシ基を有する単量体を重合又は共重合してなる
芳香族ヒドロシキ化合物について説明する。
Next, an aromatic hydroxy group obtained by polymerizing or copolymerizing a monomer having an aromatic heterocyclic hydroxy group such as an aromatic hydroxy compound having an aromatic heterocyclic hydroxy group as a substituent on a linear polymer. The compound will be described.
上記芳香族複素環式ヒドロキシ基としては、チオフェンやフランなどの複素環骨格にヒ
ドロキシ基が結合したもの（一般式（８）（９））や、複素環と芳香族環とを持つ骨格に
ヒドロキシ基が結合したもの（一般式（１０））、複素環骨格にヒドロキシ基及び炭素数
が５以下のアルキル基が結合したもの、複素環と芳香族環とを持つ骨格にヒドロキシ基及
び炭素数が５以下のアルキル基が結合したものなどが挙げられる。
Examples of the aromatic heterocyclic hydroxy group include those in which a hydroxy group is bonded to a heterocyclic skeleton such as thiophene and furan (general formulas (8) and (9)), and a skeleton having a heterocyclic ring and an aromatic ring. A group in which a group is bonded (general formula (10)), a group in which a hydroxy group and an alkyl group having 5 or less carbon atoms are bonded to a heterocyclic skeleton, and a group having a hydroxy group and carbon number in a skeleton having a heterocyclic ring and an aromatic ring. The thing etc. which 5 or less alkyl groups couple | bonded are mentioned.
そして、芳香族複素環式ヒドロキシ基が結合している線状高分子としては、特に限定さ
れず、ビニル重合体、ポリエステル、ポリアミドなどが挙げられる。この線状高分子と芳
香族複素環式ヒドロキシ基との間の化学結合については、特に限定されず、炭素−炭素結
合、エステル結合、エーテル結合、アミド結合などが挙げられる。
The linear polymer to which the aromatic heterocyclic hydroxy group is bonded is not particularly limited, and examples thereof include vinyl polymers, polyesters, and polyamides. The chemical bond between the linear polymer and the aromatic heterocyclic hydroxy group is not particularly limited, and examples thereof include a carbon-carbon bond, an ester bond, an ether bond, and an amide bond.
このような線状高分子に置換基として芳香族複素環式ヒドロキシ基を有する芳香族ヒド
ロキシ化合物としては、例えば、(1) 芳香族複素環式ヒドロキシ基を有する単量体の線状
重合体又は線状共重合体、(2) 芳香族複素環式ヒドロキシ基を有する単量体と、この単量
体と共重合可能な単量体との線状共重合体などが挙げられる。
Examples of the aromatic hydroxy compound having an aromatic heterocyclic hydroxy group as a substituent in such a linear polymer include, for example, (1) a monomer linear polymer having an aromatic heterocyclic hydroxy group or Examples thereof include a linear copolymer, (2) a linear copolymer of a monomer having an aromatic heterocyclic hydroxy group, and a monomer copolymerizable with this monomer.
上記芳香族複素環式ヒドロキシ基を有する単量体と共重合可能な単量体としては、例え
ば、エチレン、アクリレート、メタクリレート、メチルアクリレート、メチルメタクリレ
ート、ヒドロキシエチルアクリレート、ヒドロシキエチルメタクリレート、ヒドロキシプ
ロピルアクリレート、ヒドロキシプロピルメタクリレート、スチレンなどが挙げられる。
Examples of the monomer copolymerizable with the monomer having an aromatic heterocyclic hydroxy group include ethylene, acrylate, methacrylate, methyl acrylate, methyl methacrylate, hydroxyethyl acrylate, hydroxyethyl methacrylate, and hydroxypropyl acrylate. , Hydroxypropyl methacrylate, styrene and the like.
本発明の水系アレルゲン抑制剤は、上述した非水溶性アレルゲン抑制剤をｐＨ１２以上
の水溶液中に溶解させてなる。このように、水溶液のｐＨを１２以上とすることによって
、本来であれば水溶液中に殆ど溶解させることができない非水溶性アレルゲン抑制剤を水
溶液中に確実に溶解させることができる。
The water-based allergen inhibitor of the present invention is obtained by dissolving the water-insoluble allergen inhibitor described above in an aqueous solution having a pH of 12 or more. Thus, by setting the pH of the aqueous solution to 12 or more, a water-insoluble allergen inhibitor that can hardly be dissolved in the aqueous solution can be reliably dissolved in the aqueous solution.
そして、有機溶媒を用いる場合と異なり、水系アレルゲン抑制剤を製造するにあたって
、防爆設備や有機溶媒を処理するための設備を要せず、本発明の水系アレルゲン抑制剤は
、環境衛生上及び地球環境上の観点において優れている。
And unlike the case where an organic solvent is used, when manufacturing a water-system allergen inhibitor, an explosion-proof installation and the equipment for processing an organic solvent are not required, and the water system allergen inhibitor of the present invention is environmental hygiene and global environment. Excellent in terms of the above.
しかも、本発明の水系アレルゲン抑制剤は、アレルゲン抑制剤として非水溶性のものを
用いていることから、アレルゲンが存在する対象物（以下、「アレルゲン対象物」という
）に噴霧、分散、塗布などによって供給された後、アレルゲン抑制剤が空気中の水分や洗
濯水などに溶解してアレルゲン対象物から流出する事態は生じ難く、アレルゲン対象物に
付与したアレルゲン抑制効果を長期間に亘って効果的に発揮させることができる。
In addition, since the water-based allergen inhibitor of the present invention uses a water-insoluble one as the allergen inhibitor, spraying, dispersion, coating, etc. on the object in which the allergen is present (hereinafter referred to as “allergen object”) After being supplied by the allergen inhibitor, it is unlikely that the allergen inhibitor dissolves in the water or washing water in the air and flows out of the allergen object, and the allergen inhibitory effect imparted to the allergen object is effective over a long period of time. Can be demonstrated.
ここで、上記非水溶性アレルゲン抑制剤を溶解させるｐＨ１２以上の水溶液の作製要領
としては、特に限定されず、例えば、アルカリ金属塩、アルカリ土類金属塩、アンモニウ
ム塩、アミン類、アミド類などのアルカリ生成化合物を水に溶解させる方法が挙げられ、
アルカリ金属塩を水に溶解させる方法が好ましく、水酸化ナトリウム、水酸化カリウムを
水に溶解させる方法がより好ましい。なお、水溶液のｐＨは、ＪＩＳ Ｚ８８０２に準拠
して測定されたものをいう。
Here, the preparation point of the aqueous solution having a pH of 12 or higher for dissolving the water-insoluble allergen inhibitor is not particularly limited, and examples thereof include alkali metal salts, alkaline earth metal salts, ammonium salts, amines, amides, and the like. A method of dissolving an alkali-generating compound in water,
A method of dissolving an alkali metal salt in water is preferable, and a method of dissolving sodium hydroxide and potassium hydroxide in water is more preferable. In addition, pH of aqueous solution means what was measured based on JISZ8802.
そして、上記非水溶性アレルゲン抑制剤の水溶液中における含有量は、少ないと、アレ
ルゲン抑制効果を発揮しないことがある一方、多いと、水系アレルゲン抑制剤の粘度が増
大して使用勝手が悪くなることがあるので、３〜７０重量％が好ましく、１０〜５０重量
％がより好ましい。
And, if the content of the water-insoluble allergen inhibitor in the aqueous solution is small, the allergen inhibitory effect may not be exhibited. On the other hand, if the content is large, the viscosity of the water-based allergen inhibitor will increase, resulting in poor usability. 3 to 70% by weight is preferable, and 10 to 50% by weight is more preferable.
上記水系アレルゲン抑制剤の製造方法としては、特に限定されず、例えば、（１）非水
溶性アレルゲン抑制剤、アルカリ生成化合物及び水を攪拌装置に供給して攪拌し、水中に
非水溶性アレルゲン抑制剤及びアルカリ生成化合物を溶解させて水系アレルゲン抑制剤を
製造する方法、（２）アルカリ生成化合物を予め溶解させた水を攪拌装置に供給した後、
この水中に非水溶性アレルゲン抑制剤を徐々に攪拌しながら添加して溶解させる水系アレ
ルゲン抑制剤の製造方法などが挙げられる。なお、非水溶性アレルゲン抑制剤を水中に溶
解させる際に、溶解補助剤として界面活性剤を水中に添加してもよく、更に、水系アレル
ゲン抑制剤には、物性を阻害しない範囲内において、湿潤剤、増粘剤、酸化防止剤、紫外
線吸収剤などの製剤用補助剤や、殺ダニ剤、殺菌剤、防黴剤、消臭剤などが配合されても
よい。
The method for producing the water-based allergen inhibitor is not particularly limited. For example, (1) a water-insoluble allergen inhibitor, an alkali-generating compound, and water are supplied to a stirrer and stirred to inhibit water-insoluble allergen suppression in water. A method for producing an aqueous allergen inhibitor by dissolving an agent and an alkali-generating compound, (2) after supplying water in which an alkali-generating compound has been dissolved in advance to a stirrer,
Examples thereof include a method for producing an aqueous allergen inhibitor in which water-insoluble allergen inhibitor is added and dissolved in the water while gradually stirring. When the water-insoluble allergen inhibitor is dissolved in water, a surfactant may be added to the water as a solubilizing agent, and the water-based allergen inhibitor is wetted within a range that does not impair the physical properties. Additives for preparations such as agents, thickeners, antioxidants, ultraviolet absorbers, acaricides, bactericides, antifungal agents, deodorants and the like may be blended.
ここで、上記攪拌装置としては、汎用されている攪拌装置を用いることができ、水系ア
レルゲン抑制剤の製造を効率良く行なうために、集中剪断攪拌翼と全体混合翼とを備えた
攪拌装置が好ましい。
Here, as the stirring device, a widely used stirring device can be used, and a stirring device including a concentrated shear stirring blade and an entire mixing blade is preferable in order to efficiently produce an aqueous allergen inhibitor. .
そして、上記水系アレルゲン抑制剤をアレルゲン対象物に噴霧、分散又は塗布すること
によって供給することにより、アレルゲン対象物に存在するアレルゲンを抑制することが
できる。なお、上記アレルゲン対象物としては、生活空間においてアレルゲンの温床とな
る生活用品等が挙げられる。この生活用品としては、例えば、畳、絨毯、床、家具（ソフ
ァー、布ばり椅子、テーブル）、寝具（ベッド、布団、シーツ）、車内用品（シート、チ
ャイルドシート）、キッチン用品、ベビー用品、カーテン、壁紙、タオル、衣類、ぬいぐ
るみ、繊維製品、空気清浄機（本体及びフィルター）等が挙げられる。更に、上記アレル
ゲン抑制剤は、上述以外に、洗剤や柔軟仕上げ剤等に添加することによってもアレルゲン
抑制効果を発揮することができる。
And the allergen which exists in an allergen target object can be suppressed by supplying the said water-system allergen inhibitor by spraying, disperse | distributing or apply | coating to an allergen target object. In addition, as said allergen target object, the household goods etc. which become a hotbed of allergen in living space are mentioned. Examples of the daily necessities include tatami mats, carpets, floors, furniture (sofas, upholstered chairs, tables), bedding (beds, futons, sheets), in-car items (seats, child seats), kitchen items, baby items, curtains, Examples include wallpaper, towels, clothes, stuffed animals, textile products, air purifiers (main body and filter), and the like. Furthermore, in addition to the above, the allergen inhibitor can also exert an allergen inhibitory effect by being added to detergents, softeners and the like.
特に、アレルゲン対象物が繊維から形成されている場合、繊維は精練工程において一般
的にアルカリ剤を用いて処理される。従って、本発明の水系アレルゲン抑制剤は、上記精
練工程においても好適に用いることができ、上記水系アレルゲン抑制剤を用いて繊維にそ
の製造工程中にアレルゲン抑制効果を付与することができる。
In particular, when the allergen object is formed from fibers, the fibers are generally treated with an alkaline agent in the scouring process. Therefore, the aqueous allergen inhibitor of the present invention can be suitably used also in the scouring step, and the allergen suppressing effect can be imparted to the fiber during the production process using the aqueous allergen inhibitor.
更に、上記アレルゲン対象物には、空気中の水分子を集めることによって非水溶性アレ
ルゲン抑制剤がアレルゲンとの相互作用を起こし得る反応場を形成するために、吸湿性化
合物を含有させておくことが好ましい。なお、水系アレルゲン抑制剤に吸湿性化合物を含
有させておき、水系アレルゲン抑制剤をアレルゲン対象物に供給した際に、吸湿性化合物
も同時にアレルゲン対象物に供給されるようにしてもよい。
Furthermore, the allergen object should contain a hygroscopic compound in order to form a reaction field where the water-insoluble allergen inhibitor can interact with the allergen by collecting water molecules in the air. Is preferred. In addition, a hygroscopic compound may be contained in the water-based allergen inhibitor, and when the water-based allergen inhibitor is supplied to the allergen object, the hygroscopic compound may be simultaneously supplied to the allergen object.
このような吸湿性化合物としては、塩化カルシルム、塩化マグネシウム、シリカゲルな
どの無機物；ポリエチレングリコール、ポリプロピレングリコール、ポリオキシメチレン
等のポリエーテル；ポリビニルアルコール等のポリアルコール；ポリアクリル酸ナトリウ
ム塩等のポリマー塩；ポリアクリル酸等のポリマー酸等が挙げられ、吸湿性に優れ且つ捉
えた水分子を系中に放出し易いことからポリエーテルが好ましい。
Such hygroscopic compounds include inorganic substances such as calcium chloride, magnesium chloride, silica gel; polyethers such as polyethylene glycol, polypropylene glycol and polyoxymethylene; polyalcohols such as polyvinyl alcohol; polymer salts such as sodium polyacrylate. A polymer acid such as polyacrylic acid, and the like. Polyether is preferred because of its excellent hygroscopicity and easy release of captured water molecules into the system.
本発明の水系アレルゲン抑制剤が対象とするアレルゲンとしては、動物性アレルゲン、
花粉などの植物性アレルゲンが挙げられる。特に効果のある動物アレルゲンとしては、ダ
ニ類のアレルゲン（ダニ類、節足動物一蛛形綱−ダニ目の生物で、主に７つの亜目に分か
れている。アシナガダニに代表される背気門、カタダニに代表される四気門、ヤマトマダ
ニ、ツバメヒメダニに代表される後気門、イエダニ、スズメサシダニ代表される中気門、
クワガタツメダニ、ナミホコリダニに代表される前気門、コナヒョウヒダニなどのヒョウ
ヒダニ類、ケナガコナダニに代表される無気門、イエササラダニ、カザリヒワダニに代表
される隠気門等）のいずれの種類でも対象となり得るが、室内塵中、特に寝具類に多く、
アレルギー疾患の原因となるヒョウヒダニ類に特に効果がある。
The allergens targeted by the aqueous allergen inhibitor of the present invention include animal allergens,
Examples include plant allergens such as pollen. Particularly effective animal allergens include mite allergens (mites, arthropod ginsengs-mite organisms, which are mainly divided into seven subtypes. , Four air gates represented by tick mites, posterior air gates represented by tick mites, swallow tick mites, middle air gates represented by house dust mites, sparrow mite,
Any type of staghorn tick, anterior air typified by urticaria mites, leopard mites such as cyper mite, anaphysic typified by mite mite, house salad mite, anesthesia typified by tick mites) , In indoor dust, especially bedding,
Especially effective for leopard mites that cause allergic diseases.
本発明の水系アレルゲン抑制剤は、非水溶性アレルゲン抑制剤がｐＨ１２以上の水溶液
中に溶解されてなることを特徴とするので耐水性に優れており、アレルゲン対象物に噴霧
、分散、塗布などによって供給した非水溶性アレルゲン抑制剤が、空気中の水分やその他
の水分中に溶解することによってアレルゲン対象物から流出するといった事態は発生しに
くく、アレルゲン抑制効果をアレルゲン対象物に長期間に亘って効果的に付与することが
できる。
The water-based allergen inhibitor of the present invention is characterized in that the water-insoluble allergen inhibitor is dissolved in an aqueous solution having a pH of 12 or more, and is excellent in water resistance. By spraying, dispersing, coating, etc. on the allergen object The supplied water-insoluble allergen inhibitor is unlikely to flow out of the allergen object due to dissolution in moisture in the air or other moisture, and the allergen inhibitory effect is exerted on the allergen object over a long period of time. Can be effectively applied.
しかも、本発明の水系アレルゲン抑制剤は、有機溶媒を用いることなく、水溶液のｐＨ
を１２以上とすることによって非水溶性アレルゲン抑制剤を水溶液中に溶解させてなるも
のであることから、製造工程において、有機溶媒を用いる際に必要となる防爆設備や有機
溶媒の処理設備を必要とせず、環境衛生上及び地球環境上においても優れたものである。
In addition, the aqueous allergen inhibitor of the present invention can be used to adjust the pH of the aqueous solution without using an organic solvent.
Since the water-insoluble allergen inhibitor is dissolved in an aqueous solution by setting the ratio to 12 or more, an explosion-proof facility and an organic solvent treatment facility required when using an organic solvent are required in the production process. However, it is also excellent in terms of environmental sanitation and the global environment.
（実施例１）
水酸化ナトリウム（和光純薬品工業社製 試薬特級）１８重量部を水５２重量部に溶解
させた。この水溶液のｐＨは１４以上であった。そして、この水酸化ナトリウムを溶解さ
せた水中に、非水溶性アレルゲン抑制剤としてポリ−４−ビニルフェノール（アルドリッ
チ社製 重量平均分子量：８０００）２０重量部及び吸湿性化合物としてポリアクリル酸
ナトリウム（アルドリッチ社製）１０重量部を攪拌機に供給して４０００ｒｐｍの攪拌速
度で攪拌し、ポリ−４−ビニルフェノール及びポリアクリル酸ナトリウムを水中に均一に
溶解させて水系アレルゲン抑制剤を得た。
(Example 1)
18 parts by weight of sodium hydroxide (special grade reagent manufactured by Wako Pure Chemical Industries, Ltd.) was dissolved in 52 parts by weight of water. The pH of this aqueous solution was 14 or more. And in this water in which sodium hydroxide is dissolved, 20 parts by weight of poly-4-vinylphenol (weight average molecular weight: 8000) as a water-insoluble allergen inhibitor and sodium polyacrylate (Aldrich) as a hygroscopic compound 10 parts by weight) were supplied to a stirrer and stirred at a stirring speed of 4000 rpm, and poly-4-vinylphenol and sodium polyacrylate were uniformly dissolved in water to obtain an aqueous allergen inhibitor.
（実施例２）
水酸化カリウム（和光純薬品工業社製 試薬特級）８重量部を水８２重量部に溶解させ
た。この水溶液のｐＨは１４以上であった。そして、この水酸化カリウムを溶解させた水
中に、非水溶性アレルゲン抑制剤としてポリ−４−ビニルフェノール（アルドリッチ社製
重量平均分子量：２００００）５重量部及び吸湿性化合物としてポリエチレングリコー
ル（アルドリッチ社製）５重量部を攪拌機に供給して４０００ｒｐｍの攪拌速度で攪拌し
、ポリ−４−ビニルフェノール及びポリエチレングリコールを水中に均一に溶解させて水
系アレルゲン抑制剤を得た。
(Example 2)
8 parts by weight of potassium hydroxide (special grade reagent manufactured by Wako Pure Chemical Industries, Ltd.) was dissolved in 82 parts by weight of water. The pH of this aqueous solution was 14 or more. And in this water in which potassium hydroxide is dissolved, 5 parts by weight of poly-4-vinylphenol (weight average molecular weight: 20000) as a water-insoluble allergen inhibitor and polyethylene glycol (manufactured by Aldrich) as a hygroscopic compound. ) 5 parts by weight was supplied to a stirrer and stirred at a stirring speed of 4000 rpm, and poly-4-vinylphenol and polyethylene glycol were uniformly dissolved in water to obtain an aqueous allergen inhibitor.
（実施例３）
水酸化ナトリウム（和光純薬品工業社製 試薬特級）１重量部を水８６重量部に溶解さ
せた。この水溶液のｐＨは１２．５であった。そして、この水酸化ナトリウムを溶解させ
た水中に、非水溶性アレルゲン抑制剤としてポリ−Ｌ−チロシン（ＩＣＮバイオメディカ
ル社製 重量平均分子量：１５０００〜３６０００）３重量部及び吸湿性化合物としてポ
リアクリル酸ナトリウム（アルドリッチ社製）１０重量部を攪拌機に供給して４０００ｒ
ｐｍの攪拌速度で攪拌し、ポリ−Ｌ−チロシン及びポリアクリル酸ナトリウムを水中に均
一に溶解させて水系アレルゲン抑制剤を得た。
(Example 3)
1 part by weight of sodium hydroxide (special grade reagent manufactured by Wako Pure Chemical Industries, Ltd.) was dissolved in 86 parts by weight of water. The pH of this aqueous solution was 12.5. And in this water in which sodium hydroxide is dissolved, 3 parts by weight of poly-L-tyrosine (weight average molecular weight: 15000-36000, manufactured by ICN Biomedical) as a water-insoluble allergen inhibitor and polyacrylic acid as a hygroscopic compound Supply 10 parts by weight of sodium (manufactured by Aldrich) to the stirrer to 4000 r
Stirring was performed at a stirring speed of pm, and poly-L-tyrosine and sodium polyacrylate were uniformly dissolved in water to obtain an aqueous allergen inhibitor.
（比較例１）
水酸化ナトリウムを用いなかったこと、水を５２重量部の代りに７０重量部用いたこと
以外は実施例１と同様にして水系アレルゲン抑制剤を得ようとしたが、ポリ−４−ビニル
フェノールが水に溶解せず、水系アレルゲン抑制剤を得ることができなかった。なお、水
のｐＨは７であった。
(Comparative Example 1)
An aqueous allergen inhibitor was obtained in the same manner as in Example 1 except that sodium hydroxide was not used and 70 parts by weight of water was used instead of 52 parts by weight. It did not dissolve in water and an aqueous allergen inhibitor could not be obtained. The pH of water was 7.
（比較例２）
水酸化カリウムを８重量部の代わりに０．１重量部用いたこと、水を８２重量部の代り
に８９．９重量部用いたこと以外は実施例２と同様にして水系アレルゲン抑制剤を得よう
としたが、ポリ−４−ビニルフェノールが水に溶解せず、水系アレルゲン抑制剤を得るこ
とができなかった。なお、水酸化カリウムを水に溶解させて得られた水溶液のｐＨは１１
であった。
(Comparative Example 2)
An aqueous allergen inhibitor was obtained in the same manner as in Example 2 except that 0.1 part by weight of potassium hydroxide was used instead of 8 parts by weight and 89.9 parts by weight of water was used instead of 82 parts by weight. However, poly-4-vinylphenol was not dissolved in water, and an aqueous allergen inhibitor could not be obtained. The pH of the aqueous solution obtained by dissolving potassium hydroxide in water is 11
Met.
以上の如くして製造した水系アレルゲン抑制剤の溶解性及びアレルゲン抑制性を下記に
示した方法によって測定し、その結果を表１に示した。
The solubility and allergen inhibitory activity of the aqueous allergen inhibitor produced as described above were measured by the methods shown below, and the results are shown in Table 1.
（溶解性）
水系アレルゲン抑制剤を１００メッシュのふるいで濾過し、このふるい上に残った残渣
の有無を目視観察した。実施例１〜３の水系アレルゲン抑制剤では、ふるい上に残渣は無
かったが、比較例１、２の水系アレルゲン抑制剤では、ふるい上に残渣が多量に残ってい
た。
(Solubility)
The aqueous allergen inhibitor was filtered through a 100 mesh sieve, and the presence or absence of a residue remaining on the sieve was visually observed. In the aqueous allergen inhibitors of Examples 1 to 3, there was no residue on the sieve, but in the aqueous allergen inhibitors of Comparative Examples 1 and 2, a large amount of residue remained on the sieve.
（アレルゲン抑制性）
一辺１０ｃｍの平面正方形状の評価布片を２０枚用意した。各評価布片に水系アレルゲ
ン抑制剤１０ｍｌを含浸させて１００℃で１時間に亘って加熱した後、各評価布片を流水
で洗浄した。
(Allergen suppression)
Twenty pieces of evaluation cloth pieces having a flat square shape with a side of 10 cm were prepared. Each evaluation cloth was impregnated with 10 ml of an aqueous allergen inhibitor and heated at 100 ° C. for 1 hour, and then each evaluation cloth was washed with running water.
一方、エチルアルコール９０ｇ及びイオン交換水１０ｇを混合してなる溶液中に、塵ゴ
ミ（Ｄｅｒ ｐ１アレルゲン１０μｇ／ｇ含有）１ｇを分散させたアレルゲン液を作製し
た。
On the other hand, an allergen solution was prepared by dispersing 1 g of dust (containing 10 μg / g of Der p1 allergen) in a solution obtained by mixing 90 g of ethyl alcohol and 10 g of ion-exchanged water.
アレルゲン液５ｍｌを各評価布片に噴霧し、各評価布片を５０℃のオーブンで５分間に
亘って乾燥させて２０枚の汚染布片を作成した。各汚染布片の作成直後のアレルゲン量と
、各汚染布片を２５℃、７５％ＲＨ（絶対湿度１７．４ｇ／ｍ3 ）の恒温恒湿槽内に１６
時間放置後のアレルゲン量を以下の方法によって測定した。なお、汚染布片２０枚のうち
、１０枚の汚染布片を作成直後のアレルゲン量を測定するために用い、残りの１０枚の汚
染布片を１６時間放置後のアレルゲン量を測定するために用いた。又、各アレルゲン量は
、１０枚の汚染布片のアレルゲン量の相加平均とした。
Each evaluation cloth was sprayed with 5 ml of the allergen solution, and each evaluation cloth was dried in an oven at 50 ° C. for 5 minutes to prepare 20 contaminated cloth pieces. The amount of allergen immediately after preparation of each contaminated cloth piece and each contaminated cloth piece in a constant temperature and humidity chamber at 25 ° C. and 75% RH (absolute humidity 17.4 g / m 3 ) 16
The amount of allergen after standing for a period of time was measured by the following method. In addition, in order to measure the allergen amount after leaving the remaining 10 pieces of contaminated cloth pieces for 16 hours out of the 20 pieces of contaminated cloth pieces, 10 pieces of contaminated cloth pieces are used to measure the amount of allergens immediately after production. Using. Moreover, each allergen amount was taken as the arithmetic average of the allergen amount of ten contaminated cloth pieces.
先ず、汚染布片を１５ｍｌのガラス試験管に丸めて入れた後、ガラス試験管に１０ｍｌ
の抽出液（リン酸バッファー（ｐＨ７．３５）に１重量％のＢＳＡと０．０５重量％のポ
リオキシエチレン（２０）ソルビタンモノラウレートを加えたもの）を供給した。
First, the contaminated cloth piece is rolled into a 15 ml glass test tube, and then placed in a 10 ml glass test tube.
Of 1 wt% BSA and 0.05 wt% polyoxyethylene (20) sorbitan monolaurate in a phosphate buffer (pH 7.35).
しかる後、ガラス試験管を２０分間に亘ってよく振とうした後、直ちに抽出液を採取し
た。得られた抽出液中のアレルゲン量を、ＥＬＩＳＡキット（ＬＣＤアレルギー研究所社
製）を用いてＥＬＩＳＡ法に基づいて測定し、１ｍ2 あたりのＤｅｒ ｐ１量に換算した
。
Thereafter, the glass test tube was shaken well for 20 minutes, and the extract was immediately collected. The amount of allergen in the obtained extract was measured based on the ELISA method using an ELISA kit (manufactured by LCD Allergy Laboratories), and converted to the amount of Der p1 per 1 m 2 .
Claims (7)
水系アレルゲン抑制剤。 An aqueous allergen inhibitor, wherein the water-insoluble allergen inhibitor is dissolved in an aqueous solution having a pH of 12 or more.
水系アレルゲン抑制剤。 The water-based allergen inhibitor according to claim 1, comprising 3 to 70% by weight of a water-insoluble allergen inhibitor.
又は請求項２に記載の水系アレルゲン抑制剤。 The water-insoluble allergen inhibitor is an aromatic hydroxy compound.
Or the water-based allergen inhibitor of Claim 2.
のうちの少なくとも一つの置換基を有する芳香族ヒドロキシ化合物であることを特徴とす
る請求項３に記載の水系アレルゲン抑制剤。
を有する単量体を重合又は共重合させてなることを特徴とする請求項３に記載の水系アレ
ルゲン抑制剤。
素であることを特徴とする請求項４又は請求項５に記載の水系アレルゲン抑制剤。 6. The aqueous allergen inhibitor according to claim 4, wherein only one substituent R of the substituents R is a hydroxyl group, and all the other substituents R are hydrogen.
求項３に記載のアレルゲン抑制剤。 The allergen inhibitor according to claim 3, wherein the aromatic hydroxy compound is an aromatic heterocyclic hydroxy compound.
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|---|---|---|---|
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2003396095A JP4359126B2 (en) | 2003-11-26 | 2003-11-26 | Water-based allergen inhibitor |
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|---|---|
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Family
ID=34721687
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2008239721A (en) * | 2007-03-26 | 2008-10-09 | Matsushita Electric Works Ltd | Photocurable coating material for flooring topcoat and flooring material coated therewith |
| JP2018104493A (en) * | 2016-12-22 | 2018-07-05 | フマキラー株式会社 | Allergy inhibition composition |
| JP2018104494A (en) * | 2016-12-22 | 2018-07-05 | フマキラー株式会社 | Production method of allergy inhibition composition |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH09227340A (en) * | 1996-02-16 | 1997-09-02 | Mitsubishi Pencil Co Ltd | Nail enamel |
| JPH11130962A (en) * | 1997-10-30 | 1999-05-18 | Shin Etsu Chem Co Ltd | Silicone-resin-containing emulsion composition, article with cured film formed therefrom, and production thereof |
| JP2003081727A (en) * | 2000-12-22 | 2003-03-19 | Sekisui Chem Co Ltd | Allergen-reducing agent |
-
2003
- 2003-11-26 JP JP2003396095A patent/JP4359126B2/en not_active Expired - Lifetime
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH09227340A (en) * | 1996-02-16 | 1997-09-02 | Mitsubishi Pencil Co Ltd | Nail enamel |
| JPH11130962A (en) * | 1997-10-30 | 1999-05-18 | Shin Etsu Chem Co Ltd | Silicone-resin-containing emulsion composition, article with cured film formed therefrom, and production thereof |
| JP2003081727A (en) * | 2000-12-22 | 2003-03-19 | Sekisui Chem Co Ltd | Allergen-reducing agent |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2008239721A (en) * | 2007-03-26 | 2008-10-09 | Matsushita Electric Works Ltd | Photocurable coating material for flooring topcoat and flooring material coated therewith |
| JP2018104493A (en) * | 2016-12-22 | 2018-07-05 | フマキラー株式会社 | Allergy inhibition composition |
| JP2018104494A (en) * | 2016-12-22 | 2018-07-05 | フマキラー株式会社 | Production method of allergy inhibition composition |
Also Published As
| Publication number | Publication date |
|---|---|
| JP4359126B2 (en) | 2009-11-04 |
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