JP2005154414A - Skin care material for external use - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To obtain an excellent skin care material for external use having excellent stretchability and shrinkage restoring force and causing no inconveniences such as uneven spreading, back staining when an adhesive composition is applied. <P>SOLUTION: This skin care material for external use has an adhesive surface prepared by applying, spreading, coating or impregnating a water-containing adhesive on a base fabric prepared by knitting multifilament yarns of a thermoplastic synthetic resin in two or more steps of double-sided stockinette, and the formulation is brought to be one kind selected from cataplasms, plasters, packs, patches and adhesive plasters for medical use. <P>COPYRIGHT: (C)2005,JPO&NCIPI

Description

  The present invention relates to an external skin member such as an adhesive covering member such as a poultice, a plaster, a pack, a patch, and a medical bandage. More specifically, the present invention relates to a member for external use with skin, which is excellent in both stretching and width when applied, expands and contracts in accordance with the movement of the skin, and does not easily generate wrinkles.

In adhesive coating materials such as poultices, plasters, packs, patches, and medical bandages, the development of base fabrics with excellent usability that follows the movement of the skin during use applied to the skin has been promoted. ing. Japanese Patent Application Laid-Open No. 54-20128 (Patent Document 1) discloses a technique in which a woven fabric that does not stretch in the longitudinal direction and has an elongation of 50 to 130% in the lateral direction is used as a base fabric. Japanese Patent Application Laid-Open No. 6-56654 (Patent Document 2) is made of a warp knitted knit having a basis weight of 10 to 600 g / m ² using a fiber of 5 to 400 denier, and has a stretch rate in the stretch direction of 140 to 500. %, A tape preparation using a support (base fabric) having an extension rate in a right angle direction of 100 to 140% is disclosed. However, these conventional base fabrics have good extensibility but poor return, and have a problem that they are loosened by repeated stretching and shrinking operations and easily peel from the skin. Furthermore, when an adhesive composition is applied to these conventional base fabrics to produce an adhesive covering member such as a poultice, the adhesive composition oozes out to the back surface, so-called back spots are likely to occur and adhere to the skin. There is a risk of soiling clothing with adhesive that is stained on the back. Furthermore, not only woven fabrics but also non-woven fabrics are used as the base fabric of the adhesive covering member, but the non-woven fabrics also have good extensibility but poor return, loosen by repeated expansion and contraction, and peel off from the skin. There was an easy problem.

As a technique for solving such a problem, Japanese Patent Laid-Open No. 7-179335 (Patent Document 3) describes a crimped thermoplastic synthetic resin multifilament yarn that is a flat knitted fabric or an insertion yarn that is inserted into this. The knitted fabric is put in, stretched by 30 to 50% in the radial direction, and temporarily set. Next, it is subjected to squeezing with heat to fully develop the crimped state of each fiber constituting the multifilament yarn. A base fabric is disclosed. However, when an insertion thread is used, spread unevenness is likely to occur when the adhesive composition is applied to the base fabric, and there is room for improvement in order to make the amount of drug contact with the affected area uniform.
JP-A-54-20128 JP-A-6-56654 JP-A-7-179335

  The present invention provides an excellent skin external member that has stretchability and shrinkage recovery power superior to those of the prior art described above, and that does not suffer from problems such as unevenness of spreading and backside blemishes when applied with an adhesive composition. Is an issue.

In the present invention, a hydrous adhesive is applied, spread, coated, or impregnated on a base fabric in which a multifilament yarn of a thermoplastic synthetic resin that has been crimped is knitted into two or more double-sided knitted fabrics. An external skin member having an adhesive surface and having a dosage form selected from a patch, a plaster, a pack, a patch, and a medical bandage.
In the skin external member of the present invention, it is preferable that the hydrous pressure-sensitive adhesive contains a crosslinked product of polyacrylic acid and / or polyacrylate.

The skin external member according to the present invention is excellent in elasticity both in length and width, has high stretch back property after extension, stretches / shrinks in accordance with the movement of the skin when applied to the skin, and shrinks substantially equivalent to the skin after stretching There is no wrinkle because there is.
In addition, since it has a high contraction force after extension, it supports the muscle strength of the affected area softly when applied as a base material of a poultice, and functions of covering materials such as supporters that could not be done without using rubber threads or urethane threads. In addition, the function of an adhesive covering member such as a poultice can be simultaneously provided at a low cost.

The skin external member according to the present invention is mainly composed of a fabric (hereinafter referred to as a base fabric) obtained by knitting a multi-filament yarn made of thermoplastic synthetic resin that has been crimped into a circular knit. The skin external member according to the present invention was a skin external member such as an adhesive covering member such as a poultice, a plaster, a pack, a patch, or a medical adhesive bandage by applying an adhesive to one surface of the base fabric. The characteristics of the base fabric according to the present invention are as follows: (1) Although there are fabrics for poultices having a high degree of extension in conventional nonwoven fabrics and warp knitting knits, the stretch back property (closer to the shape before extension) is poor, A poultice prepared using the dough is likely to become twisted or wrinkled. The base fabric according to the present invention is superior in both stretch and width, has high stretch back property after extension, and stretches / shrinks according to the movement of the skin when applied to the skin. Therefore, the base fabric and poultice do not wrinkle.
(2) Since the base fabric according to the present invention has a high contraction force after extension (high modulus), the external skin member produced by applying an adhesive to the base fabric softly supports the muscle strength of the affected area at the time of application. In addition, the function of a supporter that could not be achieved without using a rubber thread or urethane thread and the function of an adhesive covering member such as a poultice can be simultaneously provided at a low cost.

  The fiber constituting the base fabric is a multifilament yarn made of a thermoplastic synthetic resin such as polyethylene terephthalate, polyamide, or polyolefin, and the yarn is crimped. The crimping process is a wooly process, an indented crimp process, a rubbing process, etc., and the thickness of the fiber is preferably 15 to 500 d, and one single yarn is preferably 0.1 to 10 d. The degree of crimping of the multifilament yarn is preferably a yarn having an expansion / contraction elongation of about 110 to 130% as measured by JIS L1090. This is because the individual fibers of the multifilament are further opened by crimping, and when the knit is knitted, the result is a more bulky finish. (2) Since it becomes bulky, it is possible to prevent backside blemishes when the adhesive is spread, and (3) the base fabric stretched by 120 to 300% almost returns to its original shape. In particular, the crimped Woolley process is most desirable because the fibers are opened in a spiral and the degree of crimping and bulkiness can be obtained simultaneously.

By knitting multi-filament yarn made of thermoplastic synthetic resin that has undergone the crimping process with two or more double-sided knitted fabrics, warp knitted fabrics, woven fabrics, non-woven fabrics, etc. that are used in conventional poultices and tapes Stretch back that was not possible with this was obtained, especially by using double-sided knitted fabrics of 3 or more stages, and compared to ordinary double-sided knitted fabrics, the distance between the knit stitches knitted with the cylinder and dial was increased by one or more. As a result, the fabric has a thickness of 20% or more and an elongation of 10% or more. In addition, this base fabric is a knitted fabric knitted by a double-sided knitting machine with two or more laces, and has a tearing and tensile strength per same fiber amount compared to conventional warp woven fabrics (tricot, raschel, etc.). Excellent and loose loops are easily knitted, making it easy to give stretch back and high bulkiness. Since this is a circular knitted fabric, it has a cylindrical shape, which is cut open and passed through a heating furnace in a sheet form at 120 ° C. to 230 ° C. for 30 seconds to 3 minutes, giving a heat history and setting. . At that time, the sheet-winding speed is set to 100, and the overfeed is adjusted to 80 to 150% to adjust the elongation in the vertical direction of the dough. The fabric weight at this time is 80 to 220 g / m ² , and the wale 25 to 25 50 pieces / 吋, course 25-50 pieces / 吋, 50 m / m width, test piece length 100 m / m (distance from chuck to chuck), load 300 g, vertical elongation 10-200%, horizontal A base fabric having an elongation of 10 to 500% and a length of 100 m / m of the original test piece within 150 m / m within the same width after releasing the load is produced.

  In the present invention, it is applied to an adhesive covering member such as a poultice, plaster, pack, patch, or medical adhesive bandage prepared by applying an adhesive to one surface of the base fabric having the above-described characteristics. desirable. As the pressure-sensitive adhesive used for this, various materials can be used depending on the application. Hereinafter, as a typical example of the adhesive covering member, a case where the above base fabric is applied to a poultice obtained by applying a hydrous adhesive composition to the base fabric will be mainly described.

  The pressure-sensitive adhesive composition used for this type of cataplasm is a raw material usually used for skin external members, such as surfactants, oils, alcohols, moisturizers, antioxidants, chelating agents, pH adjusters, UV absorbers, Scattering agents, amino acids, pharmacologically active substances, aqueous adhesive bases, water-soluble polymer substances, inorganic powders, preservatives, emulsifiers, curing agents (including those that crosslink polymers), curing regulators, mineral powders , Fragrance, pigment, water and the like are appropriately blended.

  Oils include castor oil, olive oil, cacao oil, palm oil, coconut oil, palm oil, tree wax, jojoba oil, grape seed oil, avocado oil, and other vegetable oils; mink oil, egg yolk oil, and other animal oils; beeswax Waxes such as whale wax, lanolin, carnauba wax, candelilla wax; hydrocarbons such as liquid paraffin, squalane, microcrystalline wax, ceresin wax, paraffin wax, petrolatum; lauric acid, myristic acid, stearic acid, oleic acid, Natural and synthetic fatty acids such as isostearic acid and behenic acid; natural and synthetic higher alcohols such as cetanol, stearyl alcohol, hexyl decanol, octyldodecanol, lauryl alcohol; isopropyl myristate, isopropyl palmitate, octyl myristate Decyl, octyldodecyl oleate, can be exemplified esters such as cholesterol oleate.

  Examples of humectants include polyhydric alcohols such as glycerin, propylene glycol, 1,3-butylene glycol, sorbitol, polyglycerin, polyethylene glycol, and dipropylene glycol; NMF components such as amino acids and sodium pyrrolidonecarboxylate; hyaluronic acid, collagen Examples thereof include water-soluble polymer substances such as mucopolysaccharides and chondroitin sulfate.

  Antioxidants include dibutylhydroxytoluene, butylhydroxyanisole, ascorbic acid and salts thereof; chelating agents include disodium edetate, ethylenediaminetetraacetic acid and salts thereof, pyrophosphoric acid and salts thereof, hexametaphosphoric acid and salts thereof Gluconic acid and its salts; Examples of pH adjusters include sodium hydroxide, potassium hydroxide, triethanolamine, aqueous ammonia, boric acid, borax, potassium hydrogen phosphate, and the like.

  Examples of the ultraviolet absorbing / scattering agent include 2-hydroxy-4-methoxybenzophenone, octyldimethylparaaminobenzoate, ethylhexylparamethoxycynamate, titanium oxide, kaolin, talc and the like.

  Examples of amino acids include glycine, alanine, valine, leucine, isoleucine, phenylalanine, tryptophan, cystine, cysteine, methionine, proline, hydroxyproline, aspartic acid, glutamic acid, arginine, histidine, lysine and derivatives thereof. .

  This poultice contains pharmacologically active substances as necessary, for example, antibiotics, chemotherapeutic agents, bacteriostatic / disinfectant / disinfectants, non-steroidal anti-inflammatory agents, steroidal anti-inflammatory agents, anticancer agents, psychotropic drugs, topical drugs Anesthetic, Antiparkinsonian, Sex hormone, Antiperspirant, Sunscreen, Antiallergic, Antiarrhythmic, Antihypertensive, Vasodilator, Vascular reinforcing agent, Muscle relaxant, Antiemetic, Psoriasis treatment , Emollients, emollients, prostaglandins, fat-soluble vitamins, enzymes, peptide hormones, diabetes treatments, polysaccharides, plant extracts and essential oils, diagnostic agents, insecticides, insect repellents, dyeings It is also possible to add agents, agricultural chemicals and the like. Specific examples of these drugs are as follows.

〔Antibiotics〕
Penicillin antibiotics such as penicillin G, penicillin V, methicillin, oxacillin, cloxacillin, ampicillin, hetacillin, cyclacillin, amoxicillin, carbenicillin, sulbenicillin. Cephalosporin antibiotics such as cephalolidine, cephalotin, cephazoline, cephaloglicin, cephalexin. Aminoglucoside antibiotics such as streptomycin, kanamycin, dibekacin, gentamicin, and fradiomycin. Tetracycline antibiotics such as oxytetracycline, tetracycline, dimethylchlorotetracycline, doxycycline, minocycline. Macrolide antibiotics such as erythromycin, leucomycin, and josamycin. Lincomycin antibiotics such as lincomycin and clindamycin. Chloramphenicol, Micamycin, Gramicidin, Gramicidin S, Capreomycin, Cycloserine, Enviomycin, Rifampicin, Nystatin, Tricomycin, Amphotericin B, Griseofulvin, Variotine, Pyrrolnitrin, Siccanin, Nitrofurantoin, 5-iodo-2 -Deoxyuridine, cefamedin, phosphonomycin, N-formimidoyl cenamycin monohydrate, etc. are mentioned.
[Chemotherapeutic agent]
Examples include sulfa drugs for external use such as mafenide acetate, sulfadiazine, silver sulfadiazine, sulfamethoxazole sodium, sulfisomidine, sulfisomidine sodium and the like.
[Bacteriostatic, disinfectant, disinfectant]
Examples include iodine, pompidone iodine, diiodohydroxypropane, benzalkonium chloride, benzethonium chloride, methyl rosaniline chloride, hexachlorophene, chlorhexidine, and benzoyl peroxide tolnaftate.
[Antifungal agent]
Naphthiomate, clotrimazole, griseofulvin, siccanin, tricomycin, nystatin, pyrrolnitrin, exalamide, croconazole hydrochloride, isoconazole nitrate, econazole nitrate, oxyconazole nitrate, sulconazole nitrate, miconazole, thioconazole, tolcyclate, varioten, haloprozine, phenyl Examples include iodoundecylate, bifonazole, naphthifine, ketoconazole, octopirox, ciclopirox, and olamine.
[Nonsteroidal anti-inflammatory agents]
Salicylic acid and its salts, salicylic acid derivatives such as aspirin, acetaminophen, aminopyrine, antipyrine, oxyphenbutazone, sulpyrine, ampenac sodium, indomethacin, diclofenac sodium, felbinac, ibuprofen, sulindac, naproxen, ketoprofen, suprofen, etofena Mate, salicylamide, triethanolamine salicylate, flufenamic acid and its salts and derivatives, meclofenamic acid and its salts and derivatives, colchicine, bufexamac, ibufenac, loxoprofen, fenbufen, diflunisal, alclofenac, phenylbuta Zon, mefenamic acid and its salts and derivatives, fenoprofen, bendazac, piroxicam, flu Bipurofen, zaltoprofen, and the like etodolac.
[Steroid anti-inflammatory agent]
Amsinoid, Prednisolone valerate, Diflucortron valerate, Betamethasone valerate, Betamethasone acetate, Dexamethasone acetate, Betamethasone dipropionate, Dexamethasone, Triamcinolone acetonide, Rilcinonide, Hydrocortisone, Flumethasone pivalate, Fluocinolide, Fluocinolone acetonide Examples include otometron, fludroxycortide, prednisolone, clobetasol propionate, beclomethasone propionate, betamethasone, methylprednisolone, methylprednisolone acetate, hydrocortisone butyrate and the like.
[Anticancer agent]
Examples include 5-fluorouracil, 6-mercaptopurine, methotrexate, bleomycin, mitomycin C, adriamycin, carbocon, actinomycin C, daunorubicin, neocartinostatin, chromomycin A, L-asparaginase, picibanil, vinplastin, vincristine and the like. .
[Psychotropic agents]
Examples include chlorpromazine, reserpine, chlordiazepoxide and the like.
[Anti-parkinsonian agent]
L-dopa, chlorzoxazone and the like can be mentioned.
[Sex hormone agent]
Examples include estrogen, androgen, estradiol, testosterone, and progesterone.
[Antiperspirant]
Propaneline bromide, scopolamine, quaternary acyloxymethylammonium salts and the like.
[Sunscreen agent]
Examples thereof include p-aminobenzoic acid, p-dimethylaminobenzoic acid, and alkyl esters thereof.
[Antiallergic agent]
Diproheptadine hydrochloride, sodium cromoglycate, ketotifen and the like can be mentioned.
[Antiarrhythmic agent]
Examples include acebutolol, alprenolol, indenolol, carteolol, bucmolol, bufetrol, bupranolol, propranolol, pindolol and the like.
(Antihypertensive agent)
Laurorfia alkaloids such as reserpine and resinamine. Examples include clonidine, prazosin, dihydroergotoxin nasylate, methiclan, methyldopa, guanethidine, and betanidin.
(Vasodilator)
Efloxate, etaphenone, oxyfedrine, carbochromene, dilazep, diltiazem, trimetazidine, pentaerythritol tetranitrate, dipyridamole, isosorbide nitrate, trapidyl, nitroglycerin, nifedipine, prenilamine, molsidomine, trolnitrate phosphate, inositol hexanicotinate, isoxpurine , Nyridrin, nitricate citrate, cyclandrate, cinnarizine, nicotinic alcohol, hepronicart and the like.
[Vessel reinforcing agent]
For example, rutin.
[Muscle relaxant]
Examples include diazepam.
[Antiemetic]
Examples include chlorpromazine.
[Psoriasis treatment agent]
And methoxalene.
[Emollient or emollient]
Hydroquinone, urea, heparin, chondroitin sulfate, salicylic acid, lactic acid, malic acid, tartronic acid, tartaric acid, pyruvic acid, 2-hydroxybutyric acid, 3-hydroxybutyric acid, glycolic acid, citric acid, ethyl methyl pyruvate, glucuronic acid, etc. It is done.
[Prostaglandins]
Prostaglandin _{F 2} alpha, prostacyclin, prostaglandin _{E 1,} prostaglandin _E 2, 7- thiaprostaglandin _E 1, 16,17,18,19,20- Pentanoru 15-cyclopentyl-7-thia prostaglandin _E 1, 16,16-dimethyl-7-thia-prostaglandin _E 1, 17,20- dimethyl-7-thia-prostaglandin _E 1, 16,17,18,19,20- Pentanoru -15- Cyclohexyl-Δ ² -7-thiaprostaglandin E ₁ , 16,16-dimethyl-Δ ² -7-thiaprostaglandin E ₁ , 7-fluoroprostacyclin, 5-fluoroprostacyclin, 16, 17, 18, 19,20-pentanol-15-cyclohexyl prostacyclin, 16, 17, 18 , 19,20-pentanol-15-cyclopentylprostacyclin and the like.
[Vitamins]
1,25-dihydroxyvitamin D ₃ , 1α-hydroxyvitamin D ₃ , 1,24-dihydroxyvitamin D ₃ , 24,25-dihydroxyvitamin D ₃ , 1α, 25-dihydroxyvitamin D ₃ -26,23-lactone, 25 -Hydroxyvitamin D ₃ -26,23-lactone, vitamin A, vitamin E, tocopherol acetate, vitamin K, vitamin B group, vitamin C, vitamin F, vitamin P, vitamin U, carnitine, ferulic acid, γ-oryzanol, α -Lipoic acid, orotic acid and derivatives thereof.
[Enzyme preparation]
Examples include trypsin, papain, protease, lysozyme, streptokinase, plasmin, urokinase, hyaluronidase, α-chymotrypsin, seratiothiopeptidase, bromelain, semi-alkaline peptidase and the like.
[Peptide hormone]
Insulin, angiotensin, vasopressin, ferripressin, protilelin, gonadotropin-releasing hormone, corticotropin, prolactin, somatropin, thyrotropin, luteinizing hormone, calcitonin, kallikrein, paracyline, glucagon, oxytocin, gastrin, secretin, serum gonadotropin, etc. .
[Diabetes treatment]
Examples include glibenclamide and gliclazide.
[Polysaccharide]
Examples include heparin and chondroitin sulfate.
(Herbal medicine)
Herbal powder such as capsaicin, and further, herb extract, herbal soft extract such as pepper extract, dry herb extract such as dried duck extract, herbal extract such as assembly extract, herbal tincture such as arnika tincture, mint oil, cinnamon Examples include essential oils such as oil, Japanese cypress, Japanese licorice, belladonna, peony, mugwort, horse chestnut, (seed, bud), chamomile (extract, essential oil), linden, sage, birch and the like. The said medicinal component can be used individually by 1 type or in combination of 2 or more types, The compounding quantity can be selected suitably.

  When the above pharmacologically active substance is blended in the pressure-sensitive adhesive composition, if the substance is listed in the Japanese Pharmacopeia or the appropriate amount is determined by other literature, etc. It is preferable to do this. It is desirable that the blending amount of other substances whose useable amount is not particularly determined is 0.0001 to 10%, preferably about 0.001 to 5%. If it is lower than 0.0001%, the effect as a pharmacologically active substance is not recognized, and the effect does not change even if 10% or more is added.

  In this poultice, it is more preferable to use an aqueous adhesive base containing a cross-linked product of polyacrylic acid and polyacrylate as the aqueous adhesive base. This aqueous adhesive base has a high moisture content and is excellent in adhesion to the skin. The cross-linked product of polyacrylic acid and polyacrylic acid salt is not particularly limited and known ones can be used. For example, JP-A Nos. 59-110614, 59-110616, and 59-110617. No. 60-99180, No. 60-260512, No. 60-260513, etc., and an aqueous adhesive base containing a metal cross-linked product of polyacrylic acid and polyacrylate is preferable.

  Specifically, any of the above polyacrylic acids can be used, and there are no particular restrictions on the molecular weight and the shape such as linear or branched chain, but those having a molecular weight of 10,000 to 10,000,000 should be used. In particular, when two or more polyacrylic acids having an average molecular weight of 10,000 to less than 500,000 to less than 500,000 to 2,000,000 and 2,000,000 to 4,000,000 are combined, the usability is improved. is there. In addition to a polymer obtained by polymerizing ordinary acrylic acid, a partially crosslinked acrylic acid polymer such as Carbopol (trade name: manufactured by Goodrich, USA) can also be suitably used.

  Polyacrylic acid salts include polyacrylic acid monovalent metal salts such as sodium polyacrylate and potassium polyacrylate, polyacrylic acid monoethanolamine, polyacrylic acid diethanolamine, polyacrylic acid triethanolamine and other polyacrylic acid. One or two or more of amine salts of acids, ammonium salts of polyacrylic acid and the like can be suitably used.

  Here, the blending ratio (weight ratio) of the polyacrylic acid salt and the polyacrylic acid is preferably 1: 0.1 to 1:10, particularly preferably 1: 1 to 1: 9. It is also possible to use a material in which the polyacrylate is partially neutralized to have the above ratio. Further, the total blending amount of polyacrylic acid and polyacrylate is preferably 0.5 to 20%, particularly 1 to 15% of the whole composition, and if less than 0.5%, the adhesive strength may be insufficient. If it exceeds 20%, the viscosity becomes high, and there may be a problem in workability during production.

  Furthermore, a cellulose derivative and a polyhydric alcohol can be added to this pressure-sensitive adhesive composition. In this case, any cellulose derivative can be used, for example, one or more of alkali metal salt of carboxymethyl cellulose, hydroxymethyl cellulose, hydroxyethyl cellulose, hydroxypropyl cellulose, methyl cellulose and the like can be used. Alkali metal salts of carboxymethyl cellulose such as sodium methyl cellulose and potassium carboxymethyl cellulose can be suitably used. In addition, when adding a cellulose derivative, it is preferable that the compounding quantity shall be 15% or less of the whole composition. If it exceeds 15%, the viscosity becomes high, which may cause problems in workability during production. In addition, any commonly used polyhydric alcohol can be used. For example, glycerin, sorbitol, ethylene glycol, diethylene glycol, triethylene glycol, polyethylene glycol, propylene glycol, polypropylene glycol, 1,3-butylene glycol, 1, One type or two or more types such as 3-propanediol, 1,4-butanediol, maltitol, and xylitol can be used. When adding a polyhydric alcohol to an adhesive composition, it is preferable that the compounding quantity shall be 50% or less of the whole composition. If it exceeds 50%, the cohesive strength of the aqueous adhesive base in the composition is lowered, and the aqueous adhesive base may remain on the adherend during peeling.

  Polyacrylic acid, polyacrylic acid salts, and water-soluble polymeric substances such as cellulose derivatives include polyvinyl alcohol, polyvinyl pyrrolidone, gelatin, pectin, vinyl pyrrolidone / vinyl acetate copolymer, hydroxypropyl cellulose, sodium alginate, xanthan gum, tragacanth Etc. may be blended. When mix | blending these water-soluble polymers, it is preferable that the compounding quantity shall be 0 to 10% of the whole adhesive composition. If it exceeds 10%, the composition becomes hard, which causes a problem when a poultice is produced.

  As preservatives, aminoethyl sulfonic acid, benzoic acid, sodium benzoate, benzyl benzoate, anteater, liquid phenol, ethanol, sodium edetate, cetylpyridinium chloride, benzalkonium chloride, benzethonium chloride, dry sodium sulfate, agar, dl-camphor, strong sump leather N (trade name: Saneigen F.F.I.), citric acid, sodium citrate, chlorocresol, chlorobutanol, gentisic acid ethanolamide, salicylic acid, sodium salicylate, dibutylhydroxytoluene 2,6-di-t-butyl-4-methylphenol, cecept (trade name: manufactured by Seiwa Kasei Co., Ltd.), sorbic acid, potassium sorbate, nitrogen, thymol, dehydroacetic acid, sodium dehydroacetate, 2-naphthol, Hi Chithiol, sucrose, honey, isobutyl paraoxybenzoate, isopropyl paraoxybenzoate, ethyl paraoxybenzoate, butyl paraoxybenzoate, propyl paraoxybenzoate, methyl paraoxybenzoate, paraformaldehyde, phenylethyl alcohol, phenol, proxel GXL : Manufactured by Zeneca), benzyl alcohol, boric acid, borax, d-borneol, l-menthol, eucalyptus oil, oxyquinoline sulfate, isopropylmethylphenol, undecylenic acid monoethanolamide, distearyldimethylammonium chloride, stearyldimethylbenzyl chloride Ammonium, stearyltrimethylammonium chloride, alkyldiaminoethylglycine hydrochloride, chlorhexidine hydrochloride (gluconic acid), ortho Phenylphenol, cresol, chloramine T, chlorxylenol, chlorphenesin, alkyl isoquinolinium bromide solution, domifene bromide, thianthol, trichlorocarbanilide, parachlorophenol, halocarban, 2- (2-hydroxy-5 -Methylphenyl) benzotriazole, hexachlorophene, resorcin, phenoxyethanol and the like can be added.

  As an emulsifier, methyl acrylate / acrylic acid-2-ethylhexyl copolymer resin emulsion, sodium N-acyl-L-glutamate, Atmos 300 (trade name: manufactured by Kao Corporation), Amacol CAB (trade name: manufactured by Eihirodo Co., Ltd.) , Allyl glycidyl ether, ethanol, ethylene glycol monomethyl ether, Emmamine D500B (trade name: manufactured by Kyoeisha Yushi Chemical Co., Ltd.), Emarex AC-10 (trade name: manufactured by Nippon Emulsion Co., Ltd.), cetylpyridinium chloride, benzalkonium chloride, Alkyldiaminoethylglycine hydrochloride solution, Euglegine C1000 (trade name: manufactured by Henkel Hakusui), octyldodecanol, oleyl alcohol, carrageenan, potassium potassium, carboxyvinyl polymer, carmellose sodium, reduced lanolin, guarga , Cloudy Base 25 (trade name: manufactured by Takada Inc.), glycerin, highly purified egg yolk lecithin, Sanimaru 234NS (trade name: manufactured by Nippon Emulsifier Co., Ltd.), Sanimaru 235 (same), Sanimaru 250-C (same), Sanimal 250C (75) (same), Sanimal 258B2 (same), Sanimal 258BA (same), Sanimal 258BA2 (same), Sanimal 258N (same), Sanimal 265 (same), Sanimal 451-KT (same), Sanimal 55-HX ( The same), Sanimal 55-LX (same), Sanimal DVP (same), Sanimal K-51 (same), Sanimal K-51 (75) (same), Sanimal PCS (same), Sanimal SN-155 (same), Sanimaru ST-451 (same), white beeswax, diisopropanolamine, diethylene glycol monobutyl ether, dioctylso Umsulfosuccinate, self-emulsifying glyceryl monostearate, polyethylene glycol distearate, dicetyl phosphoric acid, sodium dibutate, sucrose fatty acid ester, lipophilic monooleate glycerin, lipophilic glyceryl monostearate, potassium hydroxide, Sodium hydroxide, hydrogenated soybean phospholipid, hydrogenated lanolin alcohol, squalene, squalane, stearyl alcohol, stearic acid, potassium stearate, sodium stearate, polyoxyl 40 stearate, purified soybean lecithin, purified lanolin, purified egg yolk lecithin, sesqui Sorbitan oleate, cetanol, sodium cetyl sulfate, cetostearyl alcohol, cetomacrogol 1000, diethyl sebacate, gelatin, D-sorbitol, Sorpo 200 (trade name: manufactured by Toho Chemical Industry Co., Ltd.), Solpol 2242 (same), Solpol 2539A (same), Solpole 2500A (same), Solpole 2540A (same), Solpole 2676-S (same), Solpole 2720 (same) Solpole 2721 (same), Solpole 2850A (same), Solpole 2852 (same), Solpole 2942-S (same), Solpole 2944-S (same), Solpole 3006-K (same), Solpole 3006A (same), Solpole 3006DB (same), Solpole 3008-K (same), Solpole 3008A (same), Solpole 3080 (same), Solpole 3269 (same), Solpole 50 (same), Solpole 900A (same), Solpole 900B (same), Solpole AC-2357A (same), Solpol AC- 411A (same), Solpole AC-2721A (same), Solpole AE102 (same), Solpole M2242 (same), Solpole SM-100P (same), Solpole SM-100S (same), Solpole SM-200 (same), Solpole TM2 (same), soybean lecithin, talc, calcium carbonate, medium chain fatty acid triglyceride, neutral anhydrous sodium sulfate, polyoxyethylene sorbitol tetraoleate, dehimulus E (trade name: manufactured by Henkel Hakusui), kerosene, Toxanone V1D (product) Name: Sanyo Chemical Industries, Ltd.), Toxanone XK-30 (same), dodecylbenzenesulfonic acid, polyoxyethylene glyceryl triisostearate, polyoxyethylene glyceryl triisostearate (3E. O. ), Triethanolamine, sorbitan trioleate, polyoxyethylene sorbitan trioleate (20E.O.), sorbitan tristearate, Nikkor PBC-14 (trade name: manufactured by Nikko Nikko Chemicals), Nikkor Wax 220 (same as above) ), Emulsifier AC2338A (trade name: manufactured by Toho Chemical Industry Co., Ltd.), New Calgen 1015 (trade name: manufactured by Takemoto Yushi Co., Ltd.), New Calgen 1015-P (same), New Calgen 1066K (same), New Calgen 1070 (same) New Calgen 1071 (same), New Calgen 1500 TE1 (same), New Calgen 1585 TE1 (same), New Calgen 1616-D1 (same), New Calgen 1616-D6 (same), New Calgen 1616M (same), New Calgen 165 (Same), Newca Gen 185-K4 (same), New Calgen 1880SB (same), New Calgen 204 (same), New Calgen 2119-K (same), New Calgen CP-120 (same), New Calgen EP3 (same), New Calgen KH -13 (same), Newkalgen KH-15 (same), Newkalgen KH-20M (same), Newkalgen KH-25 (same), Newkalgen KL-13 (same), Newkalgen KL-20M (same) , New Calgen KL-26 (same as above), New Coal NN15 (trade name: manufactured by Nippon Emulsifier Co., Ltd.), New Pole LB-65 (trade name: manufactured by Sanyo Kasei Kogyo Co., Ltd.) ), Hymal CX-8C (trade name: manufactured by Matsumoto Yushi Seiyaku Co., Ltd.), Hymal PS-90A (same), paraffin, nonionic self-emulsifying type , Hydroxypropyl cellulose, propylene glycol, propylene glycol fatty acid ester, pectin, hosta fat KW-340 (trade name: manufactured by Hoechst), polyoxyethylene (20) polyoxypropylene (4) cetyl ether, polyoxyethylene alkyl ether , Polyoxyethylene octyl phenyl ether, polyoxyethylene oleyl ether, polyoxyethylene oleyl ether sodium phosphate, polyoxyethylene stearyl ether, polyoxyethylene cetyl ether phosphate, polyoxyethylene cetyl ether, polyoxyethylene cetyl ether phosphate Sodium (5E.O.), polyoxyethylene sorbit beeswax, polyoxyethylene sorbit beeswax (6E.O.), polio Xylethylene castor oil, polyoxyethylene behenyl ether, polyoxyethylene behenyl ether (20E. O. ), Polyoxyethylene (160) polyoxypropylene (30) glycol, polyoxyethylene lauryl ether, polyoxyethylene lanolin, polysorbate 40, polysorbate 60, polysorbate 65, polysorbate 80, macrogol 20000, macrogol 300, macrogol 400 , Myristyl alcohol, isopropyl myristate, octyldodecyl myristate, methylcellulose, methylnaphthalene, α-monoisostearyl glyceryl ether, sorbitan monooleate, polyethylene glycol monooleate, polyoxyethylene sorbitan monooleate (6E.O.) , Ethylene glycol monostearate, glyceryl monostearate, sorbitan monostearate, monostearic acid Lopylene glycol, polyethylene glycol monostearate, polyoxyethylene glyceryl monostearate, polyoxyethylene sorbitan monostearate (6E.O.), sorbitan monopalmitate, polyethylene glycol monolaurate (10E.O.) polyoxymonolaurate Ethylene sorbitan (20E.O.), medicinal soap, palm fatty acid, palm fatty acid diethanolamide, sodium N-lauroyl-L-glutamate, lauromacrogol, lauromacrogol (6E.O.), lauromacrogol (9E.O.) O.), egg yolk oil, egg yolk phospholipid, liquid paraffin, decaglycerin fatty acid ester, pentaerythritol fatty acid ester, polyoxyethylene alkyl ether, polyoxyethylene phytostanol, Polyoxyethylene lanolin alcohol / beeswax derivative, polyoxyethylene alkylamine / fatty acid amide, polyoxyethylene alkylphenyl formaldehyde condensate, alkyl sulfate, polyoxyethylene alkyl ether sulfate, N-acyl amino acid and its salt, N-acyl Methyl taurate, polyoxyethylene alkyl ether acetate, alkyl sulfocarboxylate, α-olefin sulfonate, alkyl phosphate, polyoxyethylene alkyl ether phosphate, alkyl ammonium salt, alkyl benzyl ammonium salt, betaine acetate Imidazolium betaine, lecithin, fatty acid ester, polyhydric alcohol fatty acid ester, alkyl glyceryl ether and fatty acid ester, higher alcohols, hydrocarbons, natural animal and vegetable oils, Glutamic derivatives, glycyrrhizinic acid, may be added such as glycyrrhetinic acid and derivatives thereof.

  The type of curing agent is not particularly limited, and those conventionally used for plaster can be used, but each component is uniformly mixed to prepare a plaster (adhesive composition). From the point of applying the plaster uniformly in the subsequent spreading step, those that act gradually rather than those that act immediately are preferred, and as such a curing agent, for example, a polyvalent metal compound is preferably used. Is done. In this case, magnesium compound, calcium compound, zinc compound, cadmium compound, aluminum compound, titanium compound, tin compound, iron compound, chromium compound, manganese compound, cobalt compound, nickel compound, etc. can be used as the polyvalent metal compound. In consideration of safety to the skin, it is preferable to use an aluminum compound, a magnesium compound, a calcium compound, or the like.

  In this case, any of aluminum compounds, magnesium compounds and calcium compounds can be suitably used. For example, alums such as potassium alum, ammonium alum, iron alum, aluminum hydroxide, aluminum sulfate, aluminum ammonium sulfate, potassium aluminum sulfate , Aluminum chloride, Dihydroxy aluminum amino acetate, Aluminum acetate, Aluminum oxide, Synthetic aluminum silicate, Aluminum metasilicate, Calcium carbonate, Calcium sulfate, Calcium nitrate, Calcium chloride, Calcium acetate, Calcium oxide, Calcium phosphate, Hydroxide Magnesium, magnesium carbonate, magnesium sulfate, magnesium acetate, magnesium silicate, magnesium oxide, hydroxide Alumina / magnesium, magnesium aluminate metasilicate, magnesium aluminate silicate, synthetic hydrotalcite, water-soluble compounds such as double salts containing these metals, one or more of water-insoluble compounds may be used . In addition, triglycidyl isocyanurate can be used as an epoxy curing agent, and dialdehyde starch can be used as an aldehyde curing agent. The compounding quantity of these hardening | curing agents is not specifically limited. If the blending amount is too small, the effect of blending cannot be sufficiently obtained, and if it is too large, it may be difficult to adjust the curing rate, so that it is appropriately set according to the type of curing agent to be used.

  The type of the curing regulator for adjusting the curing by the curing agent is not particularly limited, and those conventionally used for plaster and the like can be used. An acid, malic acid, tartaric acid, edetate disodium, etc. can be mentioned, These can be used individually by 1 type or in combination of 2 or more types. Although the compounding quantity of a hardening regulator can be selected suitably, 0.001 to 10% of the whole adhesive composition is suitable normally. If the blending amount is too small, the effect of blending cannot be sufficiently obtained, and if it is too large, it may be difficult to adjust the curing rate.

  Further, the type of mineral powder is not particularly limited, and those conventionally used for plaster and the like can be used. Examples of such mineral powder include kaolin, bentonite, montmorillonite, and oxidation. Zinc, titanium oxide, silicic anhydride and the like can be mentioned, and these can be used singly or in appropriate combination of two or more. Although the compounding quantity of mineral powder can be selected suitably, about 0.01 to 30% of the whole adhesive composition is preferable, More preferably, 0.1 to 15% is suitable. If the amount is too large, the plaster hardness may become so hard that it cannot be spread.

  The type of the fragrance is not particularly limited, and those conventionally used as a fragrance such as a poultice can be used. Examples of such fragrances include anise, angelica, benzoin, immortelle, chamomile, and garlic. , Cardamom, galvanum, caraway, carrot seed, guac wood, grapefruit, orange, cypress, sandalwood, cedarwood, juniper, star anise, sage, geranium, celery, thyme, tarragon, turpentine, spruce, frankincense, violet, pine , Parsley, birch, patchouli, rose, hyssop, fennel, black pepper, bodaiju flower, myrrh, yarrow, lemon, lemongrass, rosemary, laurel, shimotsukigiku, peach, cornflower, eucalyptus, yuzu, Vendor, Fennel, Daiwyo, Keihi, Chouji, Thiamine, TVen, Henoposi, Yamadin, Touka, Bergamot, Citronella, Geranium and other herbal essential oils or extracts, other lower alcohols, aldehydes, etc. 1 type can be used individually or in combination of 2 or more types as appropriate. Although the compounding quantity of a fragrance | flavor can be selected suitably, about 0.0001 to 1% is suitable with respect to the whole adhesive composition normally. If the blending amount is too small, the effect of blending cannot be obtained sufficiently, and if it is too large, there is a risk of causing skin irritation.

  Examples of substances that impart a refreshing sensation include 1-menthol, N-substituted-p-menthane-3-carboxamide, 3-substituted-p-menthane, 2- or 3-substituted-p-menthanediol, and trialkyl-substituted cyclohexane. Carboxamide and the like can be mentioned, and these can be used alone or in combination of two or more. Among these, l-menthol is particularly preferable because it exerts a strong analgesic and anti-inflammatory action. -It is desirable to use menthol alone or in combination with other cooling agents. When l-menthol is used, l-menthol itself may be blended, or it may be blended in the state of being contained in essential oil as a fragrance component, such as peppermint oil, etc. May be.

  The blending amount of the substance imparting a refreshing sensation is preferably 0.001 to 5%, particularly 0.05 to 3% of the entire pressure-sensitive adhesive composition. If it is less than 0.001%, the effect of the substance blending may not be sufficiently obtained, and if it exceeds 5%, the skin irritation may become strong.

  The type of the dye is not particularly limited, and those conventionally used in poultices and the like can be used. Examples of such a dye include Red No. 2, Red No. 3, Red No. 102, and Red. 104, Red 105, Red 106, Red 201, Red 202, Red 203, Red 204, Red 205, Red 206, Red 207, Red 208, Red 213, Red 214 Red 215, Red 218, Red 219, Red 220, Red 221, Red 223, Red 225, Red 226, Red 227, Red 228, Red 230 (1), Red 230 (2), Red 231, Red 232, Red 401, Red 404, Red 405, Red 501, Red 502, Red 503, Red 504, Red 505 Red 506, Yellow 4, Yellow 5, Yellow 201, Yellow 202 (1), Yellow 202 (2), Yellow 203, Yellow 204, Yellow 205, Yellow 401, Yellow 402 No., Yellow No. 403 (1), Yellow No. 404, Yellow No. 405, Yellow No. 406, Yellow No. 407, Green No. 3, Green No. 201, Green No. 202, Green No. 204, Green No. 205, Green No. 401, Green 402, blue 1, blue 2, blue 201, blue 202, blue 203, blue 204, blue 205, blue 403, blue 404, orange 201, orange 203, orange 204 No., orange 205, orange 206, orange 207, orange 401, orange 402, orange 403, brown 201, purple 201, purple 401, black 401, etc. Alone Or two or more in combination as appropriate can be used. The blending amount of the pigment can be selected as appropriate, but usually 0.00001 to 1.0%, particularly about 0.00005 to 0.5% is preferable with respect to the entire pressure-sensitive adhesive composition. Color can be imparted to the composition, and palatability such as appearance comfort can be enhanced. If the blending amount is too small, the effect of blending cannot be sufficiently obtained, and if it is too large, the color tone may become too strong. In addition, when mix | blending a pigment | dye, it is preferable to knead | mix a pigment | dye with other components, after dissolving a pigment | dye in water, fats and oils, etc. so that the density | concentration and spot of a pigment | dye may not arise when a composition is extended.

  When the present invention is applied to a hydrous patch, the content of water in the composition is 30 to 90%, preferably 35 to 85%, and most preferably 40 to 80%. If the water content is too low, the absorbability of the medicinal component is poor, and the feeling of use is also reduced, and if it is too high, the adhesive tends to sag. This poultice is prepared by adding a desired ingredient selected from the above-mentioned blending ingredients according to the use form and an appropriate amount of water, and kneading until uniform by a known method. The composition is uniformly applied onto a release film, and the above-described stretchable base fabric having excellent stretch-back properties is laminated thereon, or the pressure-sensitive adhesive composition is applied onto the base fabric and uniformly It is made by spreading to a certain thickness and sticking a plastic film or the like on it. Here, the cutting shape and size of the hydrous patch are not particularly limited, and various shapes such as a rectangle, a band, or a shape suitable for sticking to the nose or cheek are used depending on the usage form. it can. When a plastic film is used, the film material is preferably polyethylene, polyethylene terephthalate, or polypropylene. In addition, these films may be subjected to surface treatment with silicone or the like for the purpose of improving the peelability of the pressure sensitive adhesive during the production or use of the pressure sensitive adhesive.

  EXAMPLES Hereinafter, although an Example and a comparative example are shown and this invention is demonstrated concretely, this invention is not restrict | limited to the following Example.

<Examples 1-3>
Using a multi-filament yarn made of polyester with a thickness of 75d, knitted into a three-stage double-sided tissue, incised, and heat-treated with overfeed 120 at the take-up tension 100, containing water using a base fabric An active cataplasm was prepared. This fabric has a basis weight of 150 g / m ² , 35 wales / 吋, 33 courses / 吋, 50 m / m width, test piece length of 100 m / m (distance from chuck to chuck), and load of 300 g. The vertical elongation is 40%, the horizontal elongation is 50%, and the length after releasing the load at the same width is 100 m / m within 110 m / m. Each component described in Table 1 was mixed and sufficiently mixed with a kneader until a paste was formed, to prepare an adhesive composition. The obtained pressure-sensitive adhesive composition was uniformly applied on a base fabric (the coating amount is described in Table 1), and polypropylene was applied to prepare a poultice.

<Comparative Examples 1-6>
Each component described in Table 2 was mixed and sufficiently mixed with a kneader until a paste was formed, to prepare an adhesive composition. The obtained pressure-sensitive adhesive composition was uniformly applied onto various base fabrics described in Table 2 (the coating amount is described in Table 2), and polypropylene was applied to prepare a poultice.

<Evaluation of back Jimi>
The back spots were evaluated for each of the poultices of Examples 1 to 3 and Comparative Examples 1 to 6. Back Jimi is mixed with 0.05 part of Red No. 102 or its aluminum lake in 100 parts of the pressure-sensitive adhesive composition, and the color difference is measured by irradiation with a halogen lamp on each of the pressure-sensitive adhesive side and the base fabric side of the sheet. (A value: according to JIS8730, color difference display method).
Back spot = [base fabric side a value] / [adhesive side a value]
The contrast with sensory evaluation is as follows.
-0.3: No back spot is observed.
˜0.5: Very slight back jimi.
-0.7: Some back spots, use limit level.
0.7-: It can be confirmed that it is moist and wet.

<Evaluation of usability>
The poultices of Example 2, Comparative Example 4 and Comparative Example 5 were affixed to the elbows of 34 panelists, and sensory evaluation was performed regarding the degree of peeling and turning and the feeling of use (discomfort). The sensory evaluation for peeling and turning is shown in the graph of FIG.

  Moreover, sensory evaluation about a feeling of use (discomfort) is shown in the graph of FIG.

<Example 4>
Elastomer: 13 parts of styrene-isoprene-styrene block copolymer,
Tackifier: C9 petroleum resin 16 parts,
Softener: 1 part polybutene,
9 parts liquid paraffin,
Solvent: 60 parts cyclohexane.
After applying a pressure-sensitive adhesive composition in which 99 parts of the rubber-based pressure-sensitive adhesive is mixed with 1 part of flurbiprofen on a release paper that is PET-coated on one side with PET so that the thickness after drying is 50 μm, the pressure-sensitive adhesive composition is 60 ° C. It was dried for 30 minutes, and a base fabric having a basis weight of 150 g was laminated to obtain a poultice.

<Example 5>
Monomer: 302 parts of 2-ethylhexyl acrylate
98 parts of N-vinyl-2-pyrrolidone,
0.04 part of hexamethylene glycol dimethacrylate,
Solvent: 400 parts of ethyl acetate,
Polymerization initiator: 2 parts of lauroyl peroxide dissolved in 100 parts of cyclohexane.
The above solvent and monomer were put into an inert gas, heated to 60 ° C., and then a polymerization initiator was dropped and polymerized over 6 hours, and further reacted for 19 hours to obtain an acrylic pressure-sensitive adhesive. Ethyl acetate was appropriately added dropwise so as not to run away during the reaction. Ethyl acetate is added to the acrylic pressure-sensitive adhesive so as to have a solid content of 28%, and 1 part of ketoprofen is added to and kneaded with 99 parts of the solid content. The above mixed solution was applied onto a release paper obtained by silicone-treating PET so that the thickness after drying was 70 μm, dried at 60 ° C., and a knit support having a basis weight of 180 g was laminated on the adhesive surface to obtain a patch. .

<Example 6>
Naproxen 0.5 parts,
55 parts of silicone adhesive,
45 parts of terpene resin
5 parts isopropyl myristate (IPM).
Silicone adhesive and terpene resin were dissolved in tetrahydrofuran so that the solid content was 15 wt%, and naproxen dissolved in IPM was mixed therewith to obtain an adhesive composition. It applied so that the thickness after drying might be set to 100 micrometers on the release paper which carried out PET silicone treatment, tetrahydrofuran was volatilized at 60 degreeC, the base fabric of 130 g of fabric weight was laminated | stacked, and the poultice was obtained.

  Table 5 shows the results of the back spot evaluation for the poultices of Examples 4 to 6.

It is a graph which shows the result of sensory evaluation of the degree of peeling and turning in the Example of this invention. It is a graph which shows the result of the sensory evaluation of the usability in the Example of this invention.

Claims (2)

  Applying, spreading, coating, or impregnating a pressure-sensitive adhesive surface to a base fabric made by crimping a thermoplastic synthetic resin multifilament yarn into two or more double-sided knitted fabrics. An external skin member comprising a dosage form selected from a patch, a plaster, a pack, a patch, and a medical bandage. The skin external member according to claim 1, wherein the hydrous adhesive contains a crosslinked product of polyacrylic acid and / or polyacrylate.

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