JP2005154398A - Anticancer agent prepared by combination of lignin with edible mushroom for substituting charga mushroom, health food and feed additive - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To obtain an anticancer agent, a health food, health beverage and health feed additive, less expensive and having a high immunogenicity by substituting an expensive Chaga mushroom for solving such a problem that white beech mushroom in Chaga is extremely expensive since it is produced in cold Russia, and therefore, it is difficult to use the Chaga mushroom as an anticancer agent in general. <P>SOLUTION: The anticancer agent is obtained by using lignin and a polyphenol vanillin for substituting the very expensive Chaga mushroom, mixing a nonchlorella increasing an immunogenic antibody for getting an anticancer performance as far as in a short time, also mixing a terpene glycoside polysaccharide of Momordicae grosvernori powder, other polysaccharide powder and stevia leaf powder for improving immunogenicity, mixing glucan amino acid calcium fermented soybean paste obtained by mixing β-glucan calcium, fermented soybean paste, yeast, bean curd refuse and rice bran powder and fermenting to increase amino acids, to isolate the β-glucan for improving its absorbability as an amino acid calcium to improve the immunogenicity further. <P>COPYRIGHT: (C)2005,JPO&NCIPI

Description

Chaga 制 has a long history of anticancer effects, and its medicinal properties have been implemented in the past as follows.
1. Effective for anti-cancer and anti-cancer effects, especially digestive cancer.
2. Strengthening immunity.
3. Active oxygen removing action (SOD-like active action).
4). 4. Anti-AIDS virus action Anti-influenza virus action.
6). O-157 virus growth inhibitory action.
7). Diabetes prevention and improvement.
8). Prevention and improvement of hypertension.
9. Prevention and improvement of allergic diseases.
10. Prevention and improvement of chronic hepatitis.
11. Improvement of chronic allergic diseases.
However, this Chaga mushroom is very expensive in Japan. One of the reasons is that the inhabitants are limited to white birch forests, so many white birch are limited to a part of the cold northeastern part of Hokkaido.
As for the anticancer effect of Chaga mushroom, the healing effect has a drawback that the purpose can be achieved by taking it for a long period of 100 to 150 days on average.

As an improvement measure, the use of expensive Chaga mushrooms is limited to a small amount, and as other effective mushrooms, Ganoderma spores and Ganoderma moss are also expensive, but the immediate effect is faster than Chaga mushrooms and digests like Chaga mushrooms. It is not particularly effective for organ cancers of the organs, but has a wide range of effects on lymphatic cancer, laryngeal cancer, gastrointestinal cancer, breast cancer, uterine cancer, etc. However, there is a problem with taking a large amount.
In order to take Chaga's expensive drugs at low prices, lignin produced in large quantities from wood is used. This lignin is generally a by-product from the paper mill during the pulp manufacturing process. Many of these lignins are produced in large quantities, and some of them are mixed in the wastewater of the pulp mill, which is a cause of water pollution. is there. A part of it is recovered as mannan polysaccharide, and lignin is concentrated and used as a concrete dispersant or synthetic resin raw material, which is extremely inexpensive.
Needless to say, this lignin is a part of the wood component. For example, in the case of larch, 47.2 to 58.4% are synthetic fibers, and the α fiber system is 30.6 to 38.9% pentozan. 8 to 11.8 mannan 4.1 to 7.8% galactan 0.6 to 9.0% lignin 20.3 to 31.8% methicillin group 3.3% crude protein 0.3 to 0.5% . Pentozan, galactan, crude protein, and lignin in this wood are similar to the components of Chaga mushroom, and lignin also exerts an anticancer effect. Therefore, when this is mixed with chaga mushroom, the anticancer property is exhibited, and if the effect is lowered, the immunity is improved.

  Combining β-glucan ingredients such as agaricus, matsutake mushrooms, maitake mushrooms, shiitake mushrooms, shimeji mushrooms, oyster mushrooms, nameko mushrooms, yamabushiitake mushrooms, hanabiratake mushrooms, kofukisarokoshitake mushrooms, agaric mushrooms, enokitake mushrooms, etc. The healing time is shortened from 60 days to 70 days. Agaricus sputum is currently widely used, but Agaricus alone takes 100 days to heal. For this reason, in order to increase the immediate effect, there are many cases using the fungi of spider and the fungi of spider.

In order to reduce the amount of Chaga lees, a small amount of lignin, galactan and pentozan polysaccharides can be used to exert anti-cancer properties, and even if Chaga koji powder is reduced to 1/10, sufficient anti-cancer properties are exhibited. I understood that.

These lignins are all made from purified lignin, and there are wood chips cooked with caustic, chips cooked with sulfite, methanol extracted, phenol extracted, etc. The condition is that there is almost no yellow.
In addition to its anti-cancer effects on esophageal digestive organ cancer, lignin and chaga mushrooms are also inhibitors of viruses. In addition, the efficacy of adding β-glucan calcium to lignin improves immunity as well as anticancer.
The plant weeds are humic acids 52-62% fulvic acid 44-49% protein 50-56% cellulose 44.4% pensizan 45.4% lignin 62-69%. The class is also anticancer.

The structural model of lignin is as follows.

There are coniferyl alcohol, synapyl alcohol, and paracumal alcohol as the structure of the lignin phenylpurin raw material, but it is an amorphous heavy molecular substance having a methoxy group. This also dissolves the hemicellulose and forms an auto-oxide. This altered lignin forms a low-humidity corrosive acid containing nitrogen by combining with nitrogen compounds such as ammonia, amino acids and peptite derived from proteins of microbial cells. So-called lignin protein complexes are anticancer. Moreover, lignin loses a methoxy group by the action of microorganisms, is converted to polyphenol through a phenolic hydroxyl group, and is further oxidized to quinone.
This quinone compound is easily oxidized and polymerized into a corrosive acid. This demethyl group forms gallic acid, but this gallic acid is abundant in tea powder and is anticancerous with polyphenols. Moreover, it corresponds to the action of Chaga, which is a germicidal property against viruses.
In this lignin degradation, oxidatively decomposed siliganic acid and crocodile have strong bactericidal activity, and intermediate degradation polyphenols are also bactericidal against negative gram cocci and positive gram cocci.

The oxidation of this polyphenol and the production of the polymerization product are as follows.

The molecular structure of melanin contained in Chaga is as follows.

腐植物質の単量構造単位例（ドラグノフら）を示すと次如くである。

腐植物質の基本骨格即ち重合構造を示すと次の如くである。

The microstructural unit of humic substance is shown as follows.

An example of a unit structural unit of humic substances (Dragnov et al.) Is as follows.

The basic skeleton of the humic substance, that is, the polymerized structure is shown as follows.

With regard to the anticancer effect of Chaga mushrooms, many papers in the world were in contrast, mainly in Russia. The characteristic of the Chaga is a kind of mushroom that can be made into a birch tree. When this is extracted with water, 25 to 44% of soluble components are extracted. The biologically active substance is a chromosome formed from a chemical complex of an active phenolic aldehyde polyphenol oxidized phenol and a quinone of a chromogen polyphenol complex. In addition, substances similar to humin such as xylose are precipitated from glucose and galactato from the complex of the chromogen. All of these compounds have foaming associations with oxidized aromatic precursors biosynthesized from lignin in the birch wood part, and Chaga's Cobb (C ₂₂ H ₄₀ O ₇ ) and acids such as oxalic acid, formic acid, acetic acid, butyric acid and vanillic acid, quasi oxide benzoin, lilac acid, pyrocatechol acid, pyrogallol any aromatic acid and tri Tel Bae Neu metallo, triterpenic acids, in addition fatty acids C _10, C1 _12, C ₁₄ of Hobiritsurobin acid was present. It contains bk-t phenol, polysaccharides, pterin, lignin, cell tissues, ergosterin, lanosterin and resins. Also, minerals include SiO ₂ Fe ₂ O ₃ and B, Mg, Al, βK, Ca, Ti, Va, Cγ, Co, Ni, Cu, Zn, Ag, SrZi, Mo, Au, Sn, Ba, Ph, etc. Has been.
The chemical components (% dry matter) of Chaga's fungi and fungi are as follows.
Mycorrhiza mg /% Fungus body mg /%
Protein 2.4 23.51
Lipid 1.37 6.44
Ash content 11.27 3.04
Fiber 19.88 13.52
Dietary fiber 58.25 40.13
Carbohydrate 65.56 49.79
Ergosterol 35.3 777.6
It consists of physicochemical substances of polysaccharides contained in Chaga and water-soluble polysaccharides such as mannose, galactose, xylose, arabinose and fucose sugar homoglucan as antitumor activity, and β (1-6) glucosyl branch from NMR spectrum (Β1-3D glucan) is mainly composed of heteroglucan and the former protein complex water-soluble polysaccharide, water-insoluble polysaccharide, saponin, mainly digestive system cancer such as esophageal cancer and gastric cancer However, Chaga has a lot of origin in Russia, and a lot of white sharks are produced in northern Europe and Canada's boreal region.Chaga, which is taken from white sharks, suppresses histamine secretion and is a cancer of the stomach. Although it is preventive against tumors, it is very expensive and has quantitative limitations.
Even in other agaric agaricus, (β (1-3) (1-6)) D-glucan, α-glucan, β-galactoglucan, nucleic acid, adenolic acid tumor suppressor gene that activates cancer cells is activated, Protein glucan, fruit body polysaccharide of xyloglucan AB-P, which contains components of glucan-protein complex, glucomannan-protein complex, and AB-FP complex. However, even if you use this Chaga mushroom or Agaricus mushroom alone, you can not demonstrate anticancer properties depending on the type of cancer, so choreimaitake, Hanabira mushroom, shiitake mushroom, ganoderma mushroom Combining various edible mushrooms such as Mashimakobushi mushrooms, purple shimeji mushrooms, kofukisarno koshikake, beech mushrooms, agi mushrooms, enoki mushrooms, maitake mushrooms, yamabushiitake mushrooms, rooibosten mushrooms, nameko mushrooms, the cancer control cost is further increased.
In order to maintain the anticancer effect by using these various types of sputum, if fungal sputum is obtained by enzymatic degradation, the cost suddenly increases and cannot be obtained at a low price. Therefore, in order to make this expensive agaricus, chaga and various koji mixtures cheap, chaga uses lignin produced as a by-product in the production process of wood pulp, uses this lignin to produce lignin and mannan liquid, When mixed with Chaga, lignin mannan in the pulp can be obtained at low cost.

In addition, scraps from various soot mixtures are collected, and β-glucan is treated with both acid and alkali solutions to separate them to neutralize the smoke, and mix as weakly alkaline to mix calcium chloride and magnesium chloride. A small amount of citric acid or tartaric acid is added to the liquid, and a precipitate obtained by mixing weakly alkaline glucan with this as a coagulant is separated and washed with water, dehydrated and dried glucan powder is pulverized, and processed into nano-sized glucan calcium powder.
Here, the pulp waste liquor digested with caustic soda is concentrated to separate the lignin liquor, and the liquor is neutralized with acid to make it weakly alkaline, and calcium chloride is added to the liquor mannan calcium and general sulfite pulp. Concentrate the liquid obtained by separating the pulp refined by cooking, and further pulverize the powder dried by heating by absorbing the rice cake powder, refined rice bran and okara powder into the concentrated liquid after neutralization with calcium carbonate. However, when re-processed nanoparticles are used, even if the amount of chaga is reduced in the mixing of chaga, it exhibits anticancer properties against gastrointestinal cancer and is extremely effective.
Also, it is cheaper to make absorbents of lignin solution from bark (carp pine, red pine) with added nutrient water and sprayed with Aspergillus bacteria and lactic acid, crushed and dried fermented product for 3 months It becomes a lignin absorbent. These lignin absorbents are humin-oxidized by fermentation and contain abundant polyphenols and contain catechins, which further enhances the anticancer effect, contributing to the substitution of Chaga and lowering its production cost.
Since histamine is secreted in the gastric juice in the body supplied from blood, it creates a factor in the development of gastric ulcer, but lignin retains the action of inhibiting the secretion of histamine and prevents gastrointestinal disorders due to histamine secretion. What mixed chaga powder with this and reduced the amount of chaga mixed to 1/10 amount and added lignin powder have a preventive effect on gastrointestinal cancer.

  In addition, the fermented bark from the Noyama bamboo forest, natural bark, and fermented fiber powder of grass also contain a large amount of polyphenols. The dried product is used as a bulking agent for Chaga. Glucan calcium extracted from the biweekly mixed koji is mixed with long-term fermented miso, for example, Haccho miso, mixed with rice koji and mixed with rice koji. The fermented miso mixed glucan calcium fermented and desalted has enhanced immunity and is also anticancer. Since rice bran has many essential amino acids and proteins, when it is mixed with soybean okara powder, it is mixed with miso paste to increase more amino acids and methionine is increased to become anticancer and effective for lung cancer.

Chaga suppresses the generation of active oxygen and exerts a melanin effect.
This melanin is an antioxidant substance along with SOD, and active oxygen oxidizes cells and body fluids and causes harm to the body.
So SOD enzyme and melanin. Chaga exerts great power to improve immunity. Chaga also exhibits antibacterial properties against viral bacteria, and also has antibacterial properties against hepatitis B virus, and it is not necessary to use interferon. In addition, Chaga which increases immunity is effective for antibacterial activity against Legionella and O-157 Escherichia coli which cause pneumonia. And it goes without saying that increasing immunity increases resistance to cancer.
This increase in immunity of Chaga involves glycoproteins and polysaccharides of terpene glycoside glycosides. Pentozan, mannan and lignin contained in wood are also effective.
Originally, Chaga has antitumor properties of lignin and crocodile containing β-glucan and polyphenols, which are the main components of koji. Therefore, a mixture of lignin, β-glucan and catechin is anticancerous like Chaga.

Since the gallic acid of lignin, β-glucan calcium and catechin is anticancer, when used as an anticancer agent mixed with chaga to reduce the cost of chaga as a substitute for expensive chaga, the amount of chaga is 10 It can be reduced to a fraction.
In addition, when the long-fermented Hatcho miso is used to increase the absorption of calcium of β-glucan calcium, β-glucan is released and substituted with amino acid calcium to increase the absorption in the body and enhance the immunity. In addition, the mixture of non-chlorella with this further increases immunity and shortens the healing time, thus making Chaga's anti-cancer immunity higher.
Here, Hatcho miso with a long fermentation time was used, but this Hatcho miso has been fermented and aged for 3 years, so it contains a lot of methionine, and these rice bran powder and okara powder are mixed together. When re-fermented by mixing with yeast, rice bran flour and okara flour ferment, proteins in the body ferment to form amino acid calcium, and β-glucan further cleaves and decomposes oxygen bridges by fermentation, resulting in higher absorption. It not only reacts with the phosphoric acid in rice bran and is absorbed as a raw material for apatite, but also makes it easy to separate excess phosphoric acid and calcium.
Therefore, the present invention improves the anticancer weakness by the use of Chaga koji alone by fermentation, various β-glucan calcium and miso.
In addition, anti-cancer foods that are added with rice flour, tea powder, non-chlorella, rahan fruit powder, and glycyrrhizin have almost no side effects and can provide health foods that further enhance immunity.

It is a well-known fact that Chaga was developed in Russia, but Chaga alone is not an anti-cancer agent for all cancers, and it is particularly effective for treating cancers of the digestive system such as esophageal cancer and stomach cancer. Although not very effective for lung cancer, uterine cancer, kidney cancer, liver cancer, and other cancers, β-glucan calcium extracted from various sputum and fungus sputum and nuclei of koji increase immunity. Demonstrate its anti-cancer properties. However, Agaricus sputum alone β-glucan anticancer agent alone is not completely cureable for lymph cancer, lung cancer, uterine cancer and prostate cancer, and some cannot be cured after 60 days. The effect comes out. In addition, even in the case of expensive ganoderma spores, there are few examples that have been able to exert a healing effect in about two months, but the β-glucan component of various sputums increases immune antibodies against a wide range of cancers. However, it is necessary to devise in order to further increase the healing rate from 60%.
Chaga mushrooms cannot be completely cured with various mushrooms such as shiitake mushrooms, matsutake mushrooms, oyster mushrooms, enoki mushrooms, Shiraki mushrooms, shimeji mushrooms, garlic mushrooms, hanabiratake mushrooms, eringi, crocodile mushrooms, tamogi mushrooms, yamabushiitake and maitake mushrooms. When mixed, it improves anticancer properties and expands the range of effects on cancer types. Β (1-6) and β (1-3), which have anti-cancer effects of various moss, have little medicinal properties even if they are eaten by direct seasoning and heating of natural moss. It is necessary to cut the oxygen bridge partially to help digestion and absorption.

  In order to cut the oxygen bridge, hydrolysis with oxygen or hydrolysis with acid-alkaline water is performed. In order to increase the production yield, it is better to coagulate and recover with β-glucan calcium, but this absorption of calcium is generally absorbed only in the duodenum, but if it is converted to amino acid calcium, absorption is also performed from the stomach wall It becomes like.

In order to save expensive chaga, the recovery of lignin obtained by purifying and separating pulp waste liquor rich in polyphenols and polysaccharides was added to chaga to improve its medicinal properties and productivity.
By using a chitin chitosan extraction method based on acid and alkali decomposition, rather than using acid-alkaline or fermentative decomposition of a large number of cheap edible moss such as agaricus, chaga, or ganoderma spores Deacetylated solubilized product is converted to β-glucan calcium salt to make it an anti-cancer health food, then mixed with yeast with miso and fermented to further demineralize β-glucan calcium as amino acid calcium Improve disability.
In order to reduce the economic burden due to the use of expensive Chaga, Agaricus, and Reishi spore alone, we will make inexpensive products that enhance the anticancer effect using β-glucan from other moss species. Further, it is precipitated as β-glucan calcium salt extracted to improve productivity, washed with water, dried and then pulverized or freeze-ground to produce nanoparticles. Β-glucan and calcium are absorbed in the duodenum, especially in calcium, and in other intestines, the absorption is low. Is substituted with the amino acid calcium and β-glucan is liberated and easily absorbed, and fermented with yeast, garlic, rice bran and soybean okara powder.
It also increases the amount of methionine, that is, the amount of essential amino acids. This is desalted by diaphragm electrolysis to reduce the amount of excess salt and make a β-glucan health food ingredient.

The challenge to solve the problem

It is needless to say that Chaga is effective for gastrointestinal cancers of the digestive system, in addition to the enhancement of immune antibodies by β-glucan, and the effect of mitigating gastrointestinal wall damage under the great influence of polyphenol lignic acid. This is because the amount of histamine secreted from the blood is restricted by the secretion of acetylcholine from the autonomic nerve, and gastrointestinal damage caused by histamine is alleviated.
Therefore, it was found that when lignin extracted from pulp or wood was mixed with chaga, the amount of histamine was controlled even if the amount of chaga was reduced. This practice reduces the amount of expensive Chaga used and reduces production costs. However, when lignin is increased, the protein has an astringent action. To suppress this, the amount of glucan is increased to prevent astringency, and the amount of amino acid is further increased.
In addition, in order to extract β-glucan extracted with acid-alkaline solution from various straws with good yield, it is possible to obtain a yield of 80% or more by using calcium chloride or magnesium chloride as a coagulant. Excessive calcium and magnesium in calcium and β-glucan magnesium can cause problems, and few can cause problems. It will be absorbed from the digestive organs.
Therefore, a long-term fermented product of Hatcho miso was used as an aged fermented miso.
When this miso is fermented with yeast, soybean okara, and rice bran, the amino acids increase, and in particular, methionine increases, which is useful as a health food. By using miso that has been electrolytically desalted, the excess salt in the miso can be separated and excessive salt removal can be prevented.
Thus, when β-glucan amino acid is absorbed into the body, the absorption of calcium is improved, and the anterior tooth grows abnormally in the 20 day test, so the combination with amino acid was measured.
In this way, when β-glucan calcium, magnesium, and amino acids with lignin added to chaga are mixed with soybean okara or rice bran protein and calcium phosphate, it is not limited to the effect of dissolving chaga on other cancers. It also helps improve healing by enhancing immunity. In particular, the addition of non-chlorella further enhances immunity.

The invention's effect

The development of the present invention can reduce the amount of chaga used by adding lignin, promote the reduction of histamine secretion, and reduce the production cost to 30% or less by using fermented bark and tea powder of lignin. Of course, the same applies to the extract of fermented herbaceous plants.
In addition, Chaga has a particularly effective effect on gastrointestinal cancer of the digestive system, and by adding additives by β-glucan calcium, magnesium and amino acid fermentation, immunity enhancement and calcium absorption are increased, By mixing non-chlorella, immunity can be further enhanced, and since it is effective for other lung cancers, lymph cancers, uterine cancers, and bladder cancers, inexpensive health food additives are made. It is also used in flake foods, beverages and feed additives, and is an industrially useful invention.

  The amount of expensive Chaga anticancer agent used is reduced by 30 to 80% and mixed with lignin tannin to reduce the amount of Chaga used. To this, rice bran, soybean okara, β-glucan calcium, magnesium, and yeast miso are fermented to increase the amount of amino acids and easily absorb calcium into the body, and enhance immunity. A mixture of non-chlorella added to further improve immunity is added to health food additives, health drinks and feeds to make health foods, which are seasoned and processed into anticancer agents.

Surgery for cancer patients is reduced by taking health foods and anti-cancer drugs, and if health food conditions prevent cancer, it will reduce sudden death and delay of treatment due to delay, By processing this as an additive for nutritional health into animal feed, the mortality rate is reduced to 1/10 or less by improving immunity.
In addition, the cost of expensive Chaga is reduced and the effect of increasing immunity is exhibited.

FIG. 1 is a process diagram showing Chaga drink liquid extraction equipment and Chaga powder production. Washing and collecting dried white birch as raw material of Chaga, pulverizing it, and autoclave (2) by conveyor (1) Pump into the can through the charging port (2 '), tap water is introduced from the pipe (3), heated at a temperature of 100 to 120 ° C by the heater (4) and discharged from the pipe (5). Then press into the filter press (7) and separate.
Next, the solid matter separated by the filter press (7) is loaded on the cart (8) and conveyed to the mixer (9), and the fermenter and nutrients are transferred from the hopper (10) to the mixer from the hopper (11). Add and mix well. This mixture is introduced into the fermentation chamber (12), fermented with Aspergillus bacteria, heated with a heat sterilizer (13), and then pulverized with a Schretter (14) as a powder material and separated with a filter (7). The extracted liquid is fed into the mixer (15), mixed well with a mixture of sweetener, alcohol and nutrients while stirring with the stirrer (16) and introduced from the hopper (16 ") of the filler (16 '). And sterilized (16 '") and then bottled.
Next, the raw red pine, black pine, beech bark and husk are crushed and inserted into the can from the inlet (18 ') of the autoclave (18) through the compare (17). 19) Add other raw materials from (19 ′), heat from the heater (20), separate the concentrated material with a filter press (21), heat and concentrate the solution with a concentrating can (22), and hopper (16 ′ ) And mix. The solid matter separated is loaded on a cart (33), introduced into the fermentation chamber (12), and fermented and decomposed with Aspergillus.

Next, the pulp extracted from the wood chips is digested with caustic soda and recovered. The pulp is recovered as a solid material, used as a papermaking material, concentrated, neutralized, dehydrated by heating, and dehydrated. Dry with a spray dryer. A part of the liquid is introduced into a hopper (16 ') and mixed to form a bottle.
Akamatsu, Kuromatsu, Karamatsu, and Beech bark are neutralized by adding lactic acid bacteria, Aspergillus bacteria, chicken dung, and water, mixing them for 90 days or more, and then fermenting them at about 85% moisture at a temperature of 60-80 ° C. Then, the bark fermented fiber with a carbonization rate of 50% was collected by extracting the extract obtained by adding heated water and collecting the filtrate, which was collected by drying with a spray drier and collected as a raw material for anticancer agents. use. In addition, the solid matter after separation is used as a soil conditioner.

  In this chaga extract beverage, 25 to 45% is extracted with heated water as a soluble substance, but for taking it in the form of a health food agile powder, carbon dioxide dry ice powder and chaga rice cake are mixed as nano pulverization and the number of rotations If it grind | pulverizes with a 10000-12000 rotation mixer, nanoparticle powder will be obtained.

FIG. 2 shows the relationship between the anticancer cure rate and time for Chaga colorectal cancer.
The formulation example used in the curve is as follows.
Example 1 Chaga powder 100 parts Example 2 Chaga powder 1 part
10 parts of lignin
Tannin 10 parts
Non-chlorella powder 10 parts
β-glucan calcium Hatcho miso fermented powder 10 parts
Tanachi powder 10 parts Example 3 Lignin 10 parts
Tannin 10 parts
Bark fermented powder 10 parts
Non-chlorella powder 10 parts
β-glucan calcium Haccho miso fermented powder 10 parts Example 4 Lignin 10 parts
Tannin 10 parts
Bark fermented powder 10 parts
Non-chlorella powder 10 parts
β-glucan calcium Hatcho miso fermented powder 10 parts
Ganoderma spore powder 10 parts
10 parts of tea powder
Tanashi powder 10 parts
Chaga powder 1 part
10 parts flour
Enzyme 3 parts
Rakan fruit 20 parts Example 5 Chaga powder 10 parts
Non-chlorella powder 10 parts
Tanashi powder 10 parts
Lignin 3 parts Example 6 β-glucan calcium 10 parts
Hatcho miso fermented powder 10 parts
Non-chlorella 10 parts β-glucan calcium 10 parts, Hatcho miso 40 parts, rice koji 5 parts, soybean kaola 5 parts, tea powder koji 5 parts, and rice bran 50 parts are mixed to obtain a moisture content of 80% and 90% at room temperature. Ferment for days.
This was dried, crushed and powdered.

In the curve, (A) shows the formulation example of Example 4. (B) is from Example 3. (C) is from Example 2. (D) is the formulation example of Example 5. (F) is of the formulation example of Example 6. (E) shows the characteristics of the formulation example of Example 1.
As can be seen from this characteristic, it shows that even if the amount of Chaga used is reduced, the anticancer effect can be exerted, and the antitumor and immunity of various edible mushrooms and lignin, gallic acid, polyphenol, fermented bark powder, tannin, It was found that a mixture of Hatcho miso, β-glucan calcium, yeast, rice koji, and soybean okara flour mixed with dry powder of miso with increased methionine had a higher effect.
In the curve (E) of FIG. 2, the increase in immune antibodies is moderate with only Chaga of Formulation Example 1. However, the immunity effect by adding non-chlorella is large and the time is shortened. Those containing β-glucan calcium or a fermented product of Hatcho miso have higher immunity and shorter healing time than Chaga alone.
This figure shows that the anticancer effect of using Chaga alone takes time, and in order to increase the anticancer effect in a short time, the combination with β-glucan is higher, but the immunity is increased more quickly. If you mix non-chlorella powder, royal jelly, chlorella, etc., you will get good results.
However, Chaga mushroom is a mushroom that grows on white birch and grows by absorbing nutrients and lignin in the white birch wood, and has the effect of suppressing the generation of active oxygen. It also contains a lot of stereosaponin and melanin and also contains β-glucan, so it has a lot of gallic acid and crocodile that bacterize bacteria, bacteria and bacteria, but chlorophyll and folic acid like nonchlorella, Since vitamin C is small, the higher the content of nonchlorella, terpene glycoside polysaccharides, stevia and β-glucan, the better results are shown in order to increase immunity and shorten healing time. Reducing the amount of expensive Chaga as much as possible means lowering the production cost, and adding Chao and Stevia to Chaga, which is antibacterial to Virus, is cheap because it covers Chaga's anti-viral effect. Combination or substitution of lignin is likely.

Further, when fir shells and wood chips are digested with water at 20 atmospheres at a temperature of 165 to 200 ° C., nitrogen-containing 0.37% phosphoric acid (P ₂ O ₅ ) 0.09% potassium (K ₂ O) 0.61% Carbon-containing 33.4% Carbon nitrogen ratio 90.3% Copper (Cu) 45% Zinc (Zn) 28% Calcium (Cao) 0.11% Moisture 22.5% Alternatively, copper and zinc are removed from the extract washed with nitric acid.
If this carbon content is incinerated, the residue washed with water becomes a component of Sio ₂ 17.2% moisture 83.3% and is used as silicon for semiconductor raw materials. For lignin, a lignin solution digested with caustic or sulfite is used, but sulfur (S) and arsenic (A _S ) are removed before use.

Sitting availability

  In order to reduce the amount of chaga used as a noble drug, this invention combines lignin and β-glucan calcium, fermented amino acids, rice bran, soy bean curd, and coffee bean koji to further enhance cancer control, immune prevention, and immunity. A mixture of non-chlorella, etc., is used as an anti-cancer agent, health food, health drink, health feed additive, and it is improved in price and immediate effect.

  Chaga drink extractor and Chaga powder manufacturing process diagram   Characteristics of the relationship between anticancer cure rate and time for colorectal cancer in Chaga

Claims (1)

  In order to use lignin extracted from wood and grass plants and polyphenol vanillin as substitutes for Chaga mushrooms, each edible mushroom was neutralized by treatment with acid-alkali and coagulated and precipitated with calcium chloride and magnesium chloride. Washed and dried β-glucan calcium, mixed with Haccho miso, yeast, rice bran and okara soy flour and fermented β-glucan amino acid calcium, and further mixed with non-chlorella, rahan fructose and paddy flour Health foods, health drinks, health feed additives and cancer drugs.

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