JP2005111103A - Method for identifying tendency of occurrence of comedo - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To prevent the generation of critical comedo due to the improper selection of a cosmetic by providing a means for precisely and easily identifying tendency of occurrence of comedo on skin, so as to select the cosmetic which is applicable to the skin. <P>SOLUTION: The tendency of occurrence of comedo is identified with the amount of sebum and the amount of moisture on the skin as indexes. Specifically, it is preferable that the amounts of sebum and moisture are measured and the obtained measurement values are plotted on a coordinate plane formed with a sebum amount indication axis and a moisture amount indication axis, so as to perform determination by a plot characteristic. <P>COPYRIGHT: (C)2005,JPO&NCIPI

Description

  The present invention relates to a method for distinguishing the ease of the appearance of the skin in the skin, and more specifically, the amount of sebum and the amount of moisture in the skin as indicators. It relates to the discrimination method of ease of work.

  Combs are also called common wounds, and are one of the common abnormal conditions in the skin. The presence or absence of such complications is important in the selection of cosmetics suitable for the skin condition. It is a factor. (For example, refer to Patent Document 1, Patent Document 2, and Patent Document 3) For this reason, accurately determining the presence or absence of comedones is a very important matter in selecting cosmetics. Ordinary comedones can be easily identified by visual observation, etc. if they are clearly present, but it is difficult to distinguish them before they occur clearly or depending on the situation that is occurring. Or, it is not a direct situation of whether the amount of comedones is large or small, but “whether it has been present in the past or not” or “it is easy to make comedones compared to people” At present, it is used for cosmetics selection instead of discrimination using other substitute characteristics that are considered to be related, such as “whether or not they are recognized”. Because of this, partly, there is a common belief that "persons who are easy to get rid of are also prone to cosmetic problems". This is presumably because the substitute characteristics do not accurately substitute the characteristics of the ease of occurrence of comedones. For this reason, it has been desired to develop a means capable of more accurately distinguishing the ease of occurrence of skin comedones.

  Based on this background, various methods have been devised for differentiating the easiness of skin comedones. As such a device, for example, CTH2 and PGD2 are brought into contact with each other to determine the ease of producing comedones based on their binding characteristics (see, for example, Patent Document 4). A method for distinguishing the degree and determining the ease of making a comedone (see, for example, Patent Document 5), a method for distinguishing the ease of making a comedone by nuclear magnetic resonance (for example, see Patent Document 6), and the like. However, most of them are not suitable for practical use because they require a large-scale device such as an elizer or a nuclear magnetic resonance device, or have extremely low accuracy.

  On the other hand, a device for measuring the amount of sebum on the skin or a device for measuring the amount of moisture on the skin is commercially available as a general-purpose inexpensive device, and there is no problem in use for discrimination. There has been no known method for discriminating the easiness of skin comedones using the water content as an index.

JP 2000-201899 A JP-A-11-28193 JP-A-8-299288 JP 2002-98702 A JP-A-9-173048 JP-A-8-75685

  The present invention has been made under such circumstances, and it is an object of the present invention to provide means capable of more accurately and accurately discriminating the likelihood of skin comedones.

In view of such circumstances, the present inventors have sought to find a means that can more accurately and accurately identify the likelihood of skin comedones, and as a result of earnest research efforts, It has been found that the discrimination method, which is characterized by using the moisture content as an index, has such characteristics, and has completed the invention. That is, the present invention relates to the following technique.
(1) A method for discriminating the easiness of comedones, characterized by using the amount of sebum of the skin and the amount of water as indices.
(2) Measure the amount of sebum and moisture in the skin, plot the measured values on the coordinate plane created by the axis indicating the amount of sebum and the axis indicating the amount of water, and judging from the plot characteristics The discrimination method according to (1), characterized in that:
(3) In the discrimination method described in (2), data on the group of people who are prone to comed on the coordinate plane created by the moisture axis of the skin and the sebum axis, and the group of people with normal skin It is characterized by plotting the data in the situation where both plots can be distinguished, plotting the coordinates of the moisture content and sebum content of the subject's skin, and judging which group belongs to which is more appropriate, The discrimination method described in (2).

  ADVANTAGE OF THE INVENTION According to this invention, the means which can discriminate | determine the easiness of the occurrence of the comedones of skin more appropriately and more simply can be provided. Cosmetics suitable for the skin can be selected by this more accurate and simple discrimination of the ease of occurrence of skin comedones, and therefore, by selecting inappropriate cosmetics, It can prevent serious comedones.

  The discrimination method of the present invention is a method for discriminating the easiness of a comedone on the skin, and is characterized by using the amount of sebum and moisture in the skin as an index. Several methods are already known for measuring the amount of sebum, and these can be used. As such a method, for example, frosted glass or the like is pressed against the skin, and a method of measuring the degree of transparency of the frosted glass by sebum, a cup is pressed onto the skin, filled with chloroform, and this is collected, and sebum in this Examples thereof include a method for analyzing and quantifying the amount, and measurement using a commercially available device dedicated to quantifying sebum amount, and measurement using a device dedicated to quantifying sebum amount is particularly preferred. A particularly preferred example of such a device is Sebumeter SM810 manufactured by Courage + Khazaka. In the discrimination method of the present invention, the amount of sebum in the skin, particularly the facial skin including the area where the comedones appear, is measured and used as an index. An example of the facial skin is a cheek portion. This is because the reproducibility of the measured value is good. This is because the amount of sebum secretion varies significantly over time in the so-called T zone, such as the forehead or nose, where sebum secretion is high.

  Furthermore, in the discrimination method of the present invention, the skin water content is added to the index for discrimination. This is because, by adding such an index, the overlapping portion of the normal skin plot and the skin plot that tends to cause comedones on the sebum amount axis can be developed two-dimensionally so that it can be clearly distinguished. Such moisture measurement in the skin may be performed by a method already performed in the field of cosmetics or dermatology. For example, the moisture content of the skin is estimated from the conductance of the skin. Sukikon 100 (manufactured by EB Corporation), Corneometer CM825 (manufactured by Courage + Khazaka) and the like can be suitably exemplified.

  In order to discriminate whether or not it is easy to make comedones based on the measured amount of sebum and moisture in the skin, the measured value of the amount of moisture in the group consisting of people who have a lot of comedones in advance. And the coordinate point consisting of the measurement value of the amount of sebum, the measurement value of the moisture amount of the group consisting of normal skin people, and the coordinate point consisting of the measurement value of the sebum amount, the moisture amount axis of the skin, Plot on the coordinate plane created by the sebum axis in a situation where both plots can be distinguished, plot the subject's coordinates on this, and in the plot on the plane, which group's plot is closer to the plot of the subject? A technique for discriminating whether or not it is easy to make comedones can be preferably exemplified. This is divided into steps and shown as follows.

(Step 1) A person who is likely to have comedones is selected from a large number of unspecified subjects while observing the occurrence of comedones, and the amount of sebum on the cheeks and the amount of water are measured. Plot on the coordinate plane created by the sebum axis. At this time, the number of examples is preferably 20 or more, more preferably 30 or more.
(Step 2) From among a large number of unspecified subjects, those who are difficult to make comedones are selected based on the occurrence status of the comedones and the contents of the questionnaire responses to the person's comedones, and the amount of sebum and moisture in the cheeks Measure and plot on the coordinate plane of (Step 1) in a situation distinguishable from (Step 1).
(Step 3) Measure the amount of sebum and moisture in the cheek of a person who wants to identify the ease of making a comedones, and plot it on the plane of (Step 2). It is determined which group is close to this plot, and it belongs to the close group.

  Even if it is in a situation where the comedones cannot be observed with the naked eye by such a technique, or even if the subject himself has misrecognized in the ease of making comedones, this subject can be objectively and accurately You can distinguish the ease of making a comedy.

  By discriminating the easiness of making such an objective and accurate comedone, it is possible to select appropriate cosmetics and prevent the occurrence of a lot of comedones or the slight presence of comedones. .

  As cosmetics suitable for those who are easy to comedy, the removal of sebum, isoprene glycol and 1,4-butanediol, using a cleansing agent containing diglycerin tetraoleate, lauroyl sarcosine isopropyl, etc., suitable for removing sebum components A moisturizing agent with a low content of oils and fats, preferably containing a moisturizing agent that does not easily cause comedones and a substance that inhibits the growth of acne bacteria such as bisabopol, is preferable. Furthermore, for remarkable comedones, treatment with a cosmetic containing 4 to 10% by mass of ascorbic acid and / or a salt thereof, ascorbic acid phosphoric acid and / or a salt thereof, ascorbic acid glucoside and / or a salt thereof is preferably used. It can be illustrated. Examples of such cosmetics are shown below.

(Cleansing cosmetics)
Glycerin 75 parts by mass Isoprene glycol 5 parts by mass 1,3-butanediol 15 parts by mass “Eldue SL-205” 4 parts by mass (lauroyl sarcosine isopropyl)
Carbomer 0.4 parts by weight Water 0.3 parts by weight Triethanolamine 0.3 parts by weight

(Lotion)
Isoprene glycol 5 parts by weight Bisabopol 0.1 part by weight Phenoxyethanol 0.5 part by weight Water 94.4 parts by weight

(Cosmetic for severe acne)
Polyethylene glycol 1500 1 part by weight 1,3-butanediol 6 parts by weight glycerin 2 parts by weight ethanol 7 parts by weight citric acid 0.035 parts by weight sodium citrate 0.5 parts by weight dipotassium glycyrrhizinate 0.1 parts by weight extract 1 0 .1 part by weight extract 4 0.1 part by weight extract 5 0.1 part by weight birch extract (Ichimaru Falcos Co., Ltd.) 0.1 part by weight trimethylglycine 0.1 part by weight royal jelly 0.1 part by weight ascorbic acid phosphate Disodium salt 5 parts by weight Phenoxyethanol 0.3 part by weight POE (60) hydrogenated castor oil 0.1 part by weight Water 77.465 parts by weight

  Hereinafter, the present invention will be described in more detail with reference to examples, but it goes without saying that the present invention is not limited to such examples.

<Example 1>
Acne patients with experience in dermatological plastic surgery were selected by application, and a questionnaire survey was conducted on 385 people who had given their consent. In addition, a skin survey was conducted on 103 patients with fewer hospital visits. The skin survey was performed by measuring the amount of moisture in the skin and the amount of sebum, and the measurement site was the cheek. As a control, a woman who did not have much acne was used as a healthy person. (Questionnaire 173 people, skin measurement 35 people) As measurement conditions, makeup was removed with a cleansing agent and face washes with an aqueous facial cleanser, and the measurement was started after resting for 15 minutes. The measurement chamber was controlled at a temperature of 21 ± 2 ° C. and a humidity of 50 ± 5% RH. The water content was measured for 15 minutes after washing the face using a Corneometer CM825 manufactured by Courage + Khazaka. The amount of sebum was measured using Sebumeter SM810 manufactured by Courage + Khazaka on the cheek 60 minutes after washing the face. The results are shown in FIG. From this figure, the amount of sebum is significantly different between the comedone group and the healthy group, and as a temporary guide, when the sebum amount is 100 μg / cm ² or more, more preferably 120 μg / cm ² or more, It can be seen that the two forces can be distinguished. Furthermore, if you look in detail, there are people who are prone to comedones even when the amount of sebum is small. It can be seen that it can be distinguished. At the same time, the moisture content and sebum content were also measured for the forehead, jaw, and face line. These comparisons are shown in FIGS. 2 and 3 with the addition of cheek data. From these comparisons, it can be seen that the cheek portion having a large difference between the comedone group and the healthy group in terms of water content and sebum amount is suitable as the measurement site.

<Example 2>
And moisture content of the skin of volunteers were selected arbitrarily, where the amount of sebum was measured according to the method of Example 1, a sebum amount 122μg / cm ^2, the water content was 40 [mu] g / cm ^2. From this, this person was determined to be a person who is easy to come by. This person was aware that "I do not think that comedones are particularly easy to do", but I recommended the above-mentioned cleansing cosmetics for acne and lotions for acne. As a result, it was reported that the skin condition improved significantly. From this, it can be seen that by the discrimination method of the present invention, it is possible to accurately identify the ease of making a comedone and to select an appropriate cosmetic.

<Example 3>
Forty-three panelists who were admitted that their skin was not healthy were collected and randomly divided into a first group of 21 persons and a second group of 22 persons. The first group was asked to determine whether or not it was a person who was easy to make a comed according to self-recognition, and the second group was distinguished from the amount of sebum and the amount of water in the same way as in Example 2 whether or not it was easy to make a comedone. . In both groups, the above-mentioned cleansing and lotion for the comedones are given to the “person who is easy to make comedy”, and the following cleansing and lotion is given to the “person who is hard to make the comet” for 4 weeks. After the test, the degree of improvement of the skin was evaluated on the basis of rating 5: markedly improved, score 4: clearly improved, score 3: slightly improved, score 2: unchanged, score 1: worsening. Table 1 shows these results as average scores. From this, it can be seen that an appropriate cosmetic can be selected by distinguishing the ease of making a comedone by the discrimination method of the present invention. In addition, many people recognize themselves as “difficult to make a comed” even though it is easy to make a comedone, and it can be seen that this causes skin troubles.

(Cleansing cosmetics)
Glycerin 75 parts by mass 1,3-butanediol 20 parts by mass Cetyl isooctanoate 4 parts by mass Carbomer 0.4 parts by mass Water 0.3 parts by mass Triethanolamine 0.3 parts by mass

(Lotion)
1,3-butanediol 5 parts by mass Sodium hyaluronate 0.1 part by mass Phenoxyethanol 0.5 part by mass Water 94.4 parts by mass

  The present invention can be applied to an advice system that appropriately uses acne cosmetics.

FIG. 6 is a diagram showing the results of plotting in Example 1. It is a figure which shows the measurement site | part difference of the moisture content of Example 1. FIG. It is a figure which shows the measurement site | part difference of the sebum amount of Example 1. FIG.

Claims (3)

A method for differentiating the ease of making comedones, characterized by using the amount of sebum of the skin and the amount of water as indices. Measure the amount of sebum and moisture in the skin, and plot the measured values on the coordinate plane created by the axis indicating the amount of sebum and the axis indicating the amount of water, and judging from the plot characteristics The identification method according to claim 1, wherein: In the discrimination method according to claim 2, data of a group of people who are likely to cause comedones on a moisture plane of the skin and a coordinate plane formed by a sebum amount axis, and data of a group of people with normal skin in advance Is plotted in a situation where both plots can be distinguished, and the coordinates of the moisture content and sebum content of the subject's skin are plotted to determine which group is more appropriate. The differentiation method described in.

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