JP2005092434A - Check system, check device and method, information processor and information processing method, information provider and information providing method, recording medium and its program - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To record biological information by preventing a patient from being specified, and to allow the patient to read his or her own biological information. <P>SOLUTION: A bioassay device 12 detects the connection of detection substances and target substances, and reads substrate ID from a bioassay substrate 11, and acquires disease information, and transmits biological information, the substrate ID and disease information to a server 15. A data processor 16 acquires user ID to specify the patient, the substrate ID and an encryption key, and encrypts the substrate ID by the encryption key, and transmits the user ID and the encrypted substrate ID to the server 15. The server 15 receives the information, and records the detection information and the disease information by associating the information with the substrate ID, and records the encrypted substrate ID by associating the information with the user ID. This invention may be applied to a check system. <P>COPYRIGHT: (C)2005,JPO&NCIPI

Description

  The present invention relates to an inspection system, an inspection apparatus and method, an information processing apparatus and method, an information providing apparatus and method, a recording medium, and a program, and more particularly, an inspection system that records and reads out the result of an inspection of biological information. The present invention relates to an inspection apparatus and method, an information processing apparatus and method, an information providing apparatus and method, a recording medium, and a program.

  An integrated substrate for so-called DNA chips or DNA microarrays (hereinafter collectively referred to as “DNA chips”) in which predetermined DNA (deoxyribonucleic acid) is finely arranged by microarray technology is currently used for gene mutation analysis. It is used for SNPs (single nucleotide polymorphism) analysis, gene expression frequency analysis, etc. and has begun to be widely used in fields such as drug discovery, clinical diagnosis, pharmacogenomics, forensic medicine and others.

  Since this DNA chip has a large number of DNA oligo chains and cDNA (Complementary DNA) integrated on a glass substrate or silicon substrate, comprehensive analysis of intermolecular interactions such as hybridization becomes possible. The point is a feature.

  To briefly explain an analysis method using a DNA chip, mRNA (messenger ribonucleic acid) extracted from cells, tissues, etc. is reverse-transcribed by PCR (single-phased DNA probes on glass or silicon substrates). This is a technique in which PCR amplification is performed while incorporating a fluorescent probe dNTP (deoxyribonucleoside triphosphate) by a Polymerase Chain Reaction) reaction, etc., hybridization is performed on a substrate, and fluorescence measurement is performed with a predetermined detector.

  Here, DNA chips can be classified into two types. The first type is to synthesize oligonucleotides directly on a predetermined substrate using a photolithographic technique applying a semiconductor exposure technique, typically by Affimetrix. (For example, refer to Patent Document 1). Although this type of chip has a high degree of integration, there is a limit to DNA synthesis on the substrate, and the length is about several tens of bases.

  The second type is also referred to as “Stanford method”, and is created by dispensing and individualizing previously prepared DNA on a substrate using a tip-breaking pin ( For example, see Patent Document 2). This type of chip is less integrated than the former, but has the advantage that it can individualize DNA fragments of about 1 kb.

  The results of analysis using these DNA chips are stored and managed individually by analysts, researchers, doctors, or, in some cases, individuals, and used for comparison with new data as necessary. It had been.

  In addition, the information center records the bio product code, information about the bio product, bio information about the product user, etc., or obtains it from the database as necessary, including quality assurance of the bio product. There is also a system that provides information related to bio products (see, for example, Patent Document 3). In this system, the information center processes the information and distributes it to the terminal so that the bio product user can efficiently and easily acquire the update information.

Japanese National Patent Publication No. 4-505863

Japanese National Patent Publication No. 10-503841

JP 2001-243325 A

  However, as described above, analysis results using the conventional DNA chip technology are individually stored and managed by analysts, researchers, doctors, individuals, etc., so a large number are collected and analyzed, and the analysis results It was difficult to make use of this for new research and diagnosis.

  Also, even if each analyst, researcher, or doctor performs the analysis process in cooperation, it cannot be said that the privacy of the patient (the subject of the examination) is considered, and the patient himself / herself has his / her own data. I could n’t even access.

  In the inspection system of the present invention, a detection substance for detecting a target substance is arranged on a substrate, a board ID for identifying itself is recorded, and the inspection apparatus detects a binding between the detection substance and the target substance on the board. Means, reading means for reading out the substrate ID from the substrate, acquisition means for acquiring state information relating to the user's state corresponding to the user's operation, and the result of detection of the target substance addressed to the information providing device via the network And a first communication control means for controlling transmission of detection information, board ID, and status information, and an information processing device for encrypting the user ID, board ID, and board ID for identifying the user An acquisition means for acquiring an encryption key, an encryption means for encrypting a board ID based on the encryption key, and a user ID and an encrypted board ID sent to the information providing apparatus via the network And a second communication control means for controlling the information, the information providing device receives the detection information, the substrate ID, and the state information transmitted from the inspection device, and the user ID transmitted from the information processing device. And a third communication control means for controlling reception of the encrypted board ID, a first record management means for managing the record of detection information and status information corresponding to the board ID, and a user ID And a second record management means for managing the record of the encrypted substrate ID.

  The second record management means of the information providing device, when a request for a substrate ID is transmitted together with a user ID from the information processing device, is an encrypted substrate ID recorded corresponding to the user ID The third communication control means of the information providing device controls the transmission of the encrypted board ID addressed to the information processing device via the network, and controls the second communication control of the information processing device. The means controls reception of the encrypted board ID transmitted from the information providing apparatus, and the information processing apparatus further includes decryption means for decrypting the encrypted board ID with the encryption key. Can be provided.

  The first recording management unit of the information providing device controls reading of the detection information recorded corresponding to the substrate ID when a request for detection information is transmitted together with the substrate ID from the information processing device. The third communication control means of the information providing apparatus controls transmission of the detection information addressed to the information processing apparatus via the network, and the second communication control means of the information processing apparatus is transmitted from the information providing apparatus. In addition, reception of detection information can be controlled.

  The inspection apparatus according to the present invention acquires detection information for detecting a binding between a detection substance and a target substance on a substrate, reading means for reading a substrate ID from the substrate, and status information relating to a user's state corresponding to a user operation. And acquisition means for transmitting, and transmission control means for controlling transmission of detection information indicating the detection result of the target substance, the substrate ID, and the state information to other apparatuses via the network.

  According to the inspection method of the present invention, a detection step for detecting binding between a detection substance and a target substance on a substrate, a reading step for reading a substrate ID from the substrate, and state information relating to a user's state corresponding to a user operation are acquired. And a transmission control step for controlling transmission of detection information indicating the detection result of the target substance, the substrate ID, and the state information to another device via the network.

  The program of the first recording medium of the present invention includes a detection step for detecting a binding between a detection substance and a target substance on a substrate, a reading step for reading a substrate ID from the substrate, and a user state corresponding to a user operation. And a transmission control step for controlling transmission of detection information indicating the detection result of the target substance, the substrate ID, and the state information to other devices via the network. Features.

  According to a first program of the present invention, a computer detects, in a computer, a detection step for detecting a binding between a detection substance and a target substance, a reading step for reading a substrate ID from the board, and a user state corresponding to a user operation. An acquisition step for acquiring state information on the device, and a transmission control step for controlling transmission of detection information indicating the result of detection of the target substance, substrate ID, and state information to other devices via the network It is characterized by.

  The information processing apparatus of the present invention obtains a user ID for identifying a user, a substrate ID for identifying a substrate on which a detection substance for detecting a target substance is arranged, and an encryption key for encrypting the board ID And an encryption means for encrypting the substrate ID based on the encryption key, and a user ID and an encrypted substrate addressed to another device for recording and providing the result of the inspection of the substrate via the network Communication control means for controlling transmission of the ID.

  The communication control means further transmits a request for the board ID together with the user ID to the other apparatus via the network, and communicates so as to receive the encrypted board ID transmitted from the other apparatus. And a decrypting means for decrypting the received encrypted board ID with the encryption key can be further provided.

  The communication control means further transmits a request for detection information indicating the detection result of the target substance together with the substrate ID to the other apparatus via the network, and receives the detection information transmitted from the other apparatus. So that the communication can be controlled.

  The information processing method of the present invention obtains a user ID for identifying a user, a substrate ID for identifying a substrate on which a detection substance for detecting a target substance is arranged, and an encryption key for encrypting the board ID. And an encryption step for encrypting the board ID based on the encryption key, and a user ID and an encrypted board addressed to another device for recording and providing the result of the board inspection via the network. And a communication control step for controlling transmission of the ID.

  The program of the second recording medium of the present invention includes a user ID for specifying a user, a board ID for specifying a board on which a detection substance for detecting a target substance is arranged, and an encryption key for encrypting the board ID. An acquisition step to acquire, an encryption step to encrypt the board ID based on the encryption key, and a user ID and encryption addressed to another device that records and provides the result of the inspection of the board via the network And a communication control step for controlling transmission of the substrate ID.

  A second program according to the present invention includes: a user ID for identifying a user; a board ID for identifying a board on which a detection substance for detecting a target substance is disposed; and an encryption key for encrypting the board ID. An acquisition step to acquire, an encryption step to encrypt the board ID based on the encryption key, and a user ID and encryption addressed to another device that records and provides the result of the inspection of the board via the network And a communication control step for controlling transmission of the substrate ID.

  The information providing apparatus according to the present invention is a substrate on which a detection substance for detecting a target substance is arranged, which is transmitted from an inspection apparatus that inspects a board on which a board ID for identifying itself is recorded. Detection information indicating the result of detection of the binding between the detection substance and the target substance, the board ID, and the status information related to the user status, and the user ID and the encrypted board ID transmitted from another device Communication control means for controlling the reception of information, first record management means for managing the record of detection information and status information corresponding to the board ID, and the encrypted board ID corresponding to the user ID. And second recording management means for managing recording.

  The second record management means controls reading of the encrypted board ID recorded corresponding to the user ID when a request for the board ID is transmitted together with the user ID from another apparatus. Then, the communication control means can control transmission of the encrypted board ID addressed to another apparatus via the network.

  When a request for detection information is transmitted together with the substrate ID from another apparatus, the first record management unit controls reading of the detection information recorded corresponding to the substrate ID, and communication control unit Can control the transmission of detection information addressed to other devices via the network.

  The information providing apparatus can further include an analysis unit that analyzes the relationship between the recorded detection information and state information.

  The first record management unit controls reading of the analysis result related to the detection information when a request for the analysis result is transmitted from another device, and the communication control unit addresses the other device via the network. The transmission of the analysis result can be controlled.

  The first record management unit controls reading of the analysis result related to the detection information recorded corresponding to the substrate ID when a request for the analysis result is transmitted together with the substrate ID from another apparatus. Can be.

  The information providing method of the present invention is a substrate on which a detection substance for detecting a target substance is arranged, which is transmitted from an inspection apparatus that inspects a board on which a board ID for identifying itself is recorded. Detection information indicating the result of detection of the binding between the detection substance and the target substance, the board ID, and the status information related to the user status, and the user ID and the encrypted board ID transmitted from another device A communication control step for controlling reception, a first record management step for managing detection information and status information recording corresponding to the substrate ID, and an encrypted substrate ID corresponding to the user ID. And a second record management step for managing records.

  The program of the third recording medium of the present invention has been transmitted from an inspection apparatus that inspects a substrate on which a detection substance for detecting a target substance is arranged and on which a board ID for identifying itself is recorded. In addition, the detection information indicating the detection result of the binding between the detection substance and the target substance on the substrate, the reception of the state information on the substrate ID and the user state, and the user ID and the encryption transmitted from another device are encrypted. A communication control step for controlling reception of the board ID, a first record management step for managing detection information and status information recording corresponding to the board ID, and an encryption corresponding to the user ID And a second record management step for managing the record of the board ID.

  The third program of the present invention has been transmitted from an inspection apparatus for inspecting a substrate on which a detection substance for detecting a target substance is arranged and a board ID for identifying itself is recorded to a computer. In addition, the detection information indicating the detection result of the binding between the detection substance and the target substance on the substrate, the reception of the state information on the substrate ID and the user state, and the user ID and the encryption transmitted from another device are encrypted. A communication control step for controlling reception of the board ID, a first record management step for managing detection information and status information recording corresponding to the board ID, and an encryption corresponding to the user ID And a second recording management step for managing the recording of the substrate ID being recorded.

  The network is a mechanism in which at least two devices are connected and information can be transmitted from one device to another device. The devices that communicate via the network may be independent devices, or may be internal blocks that constitute one device.

  The communication is not only wireless communication and wired communication, but also communication in which wireless communication and wired communication are mixed, that is, wireless communication is performed in a certain section and wired communication is performed in another section. May be. Further, communication from one device to another device may be performed by wired communication, and communication from another device to one device may be performed by wireless communication.

  The inspection apparatus may be an independent apparatus or a block that performs an inspection process.

  The information processing apparatus may be an independent apparatus or a block that performs information processing.

  The information providing apparatus may be an independent apparatus or a block that performs information providing processing.

  In the inspection system of the present invention, a detection substance for detecting a target substance is arranged, a board ID for identifying itself is recorded, a binding between the detection substance and the target substance on the board is detected, and the board ID is read from the board. It is. Then, state information relating to the user's state corresponding to the user's operation is acquired, and detection information, a substrate ID, and state information indicating the detection result of the target substance are transmitted to the information providing apparatus via the network. The In addition, a user ID for identifying a user, a board ID, and an encryption key for encrypting the board ID are acquired, and the board ID is encrypted based on the encryption key and is sent to the information providing apparatus via the network. The user ID and the encrypted board ID are transmitted. Then, the detection information, the board ID, and the state information transmitted from the inspection apparatus are received, and the user ID and the encrypted board ID transmitted from the information processing apparatus are received, and the board ID is received. Correspondingly, detection information and status information are recorded, and an encrypted substrate ID is recorded corresponding to the user ID.

  In the inspection apparatus and method, the first recording medium, and the first program of the present invention, the binding between the detection substance and the target substance on the substrate is detected, and the substrate ID is read from the substrate for user operation. Corresponding state information regarding the user state is acquired, and detection information, a substrate ID, and state information indicating a result of detection of the target substance are transmitted to another apparatus via the network.

  In the information processing apparatus and method, the second recording medium, and the second program of the present invention, a user ID for specifying a user, a substrate ID for specifying a substrate on which a detection substance for detecting a target substance is arranged, and a board An encryption key for encrypting the ID is obtained, the board ID is encrypted based on the encryption key, and the user is sent to another device that records and provides the result of the board inspection via the network. The ID and encrypted board ID are transmitted.

  In the information providing apparatus and method, the third recording medium, and the third program of the present invention, a substrate ID on which a detection substance for detecting a target substance is arranged and a board ID that identifies itself is recorded. Detection information indicating the result of detection of the binding between the detection substance and the target substance on the board, the board ID, and the status information on the user state transmitted from the inspection apparatus that inspects the existing board, and from other apparatuses The reception of the transmitted user ID and encrypted board ID is controlled, the record of detection information and status information corresponding to the board ID is managed, and the encrypted corresponding to the user ID is encrypted. Records of existing board IDs are managed.

  According to the present invention, the patient's biological information is concentrated and recorded so that the patient cannot be identified, and the patient can read out his / her biological information.

  In other words, according to the present invention, biological information collected from a patient can be analyzed in consideration of privacy, and analysis results can be widely provided to analysts, researchers, doctors, and patients themselves can You can access the data.

  In other words, in the present invention, not only gene analysis is performed using a bioassay substrate, but also new data is created by collecting, storing and managing the data, and analyzing the collected information in an integrated manner. By feeding back the analysis results to genetic analysis, it is possible to lead to more accurate and faster diagnosis, research, and drug discovery.

  In addition, since individuals can access their own data accurately, they can protect their right to know while protecting their privacy.

  Embodiments of the present invention will be described below. The correspondence relationship between the invention described in this specification and the embodiments of the invention is exemplified as follows. This description is intended to confirm that the embodiments supporting the invention described in this specification are described in this specification. Therefore, although there is an embodiment which is described in the embodiment of the invention but is not described here as corresponding to the invention, it means that the embodiment is not It does not mean that it does not correspond to the invention. Conversely, even if an embodiment is described herein as corresponding to an invention, that means that the embodiment does not correspond to an invention other than the invention. Absent.

  Further, this description does not mean all the inventions described in this specification. In other words, this description is for the invention described in the present specification, which is not claimed in this application, that is, for the invention that will be applied for in the future or that will appear and be added by amendment. It does not deny existence.

  According to the present invention, an inspection system is provided. This inspection system (for example, the inspection system 1 in FIG. 1) is a detection substance (for example, the probe in FIG. 5) that detects a target substance (for example, a nucleotide chain) on a substrate (for example, the bioassay substrate 11 in FIG. 1). Is placed, a substrate ID for identifying itself (for example, a substrate ID recorded in the recording area 32) is recorded, and an inspection device (for example, the bioassay device 12 in FIG. 1) Detection means (for example, excitation light detection unit 73 in FIG. 6) for detecting the binding with the substance, readout means for reading the substrate ID from the substrate (for example, excitation light detection unit 73 and recording / reproduction unit 75 in FIG. 6), An acquisition unit (for example, the input unit 79 in FIG. 6) for acquiring state information (for example, medical condition information) corresponding to the user's operation, and a network (for example, the interface in FIG. 1). A first control unit that controls transmission of detection information (for example, biological information), a substrate ID, and state information indicating the detection result of the target substance addressed to the information providing apparatus (for example, the server 15 in FIG. 1) via the network 14). 1 (for example, the network interface 77 in FIG. 6), the information processing device (for example, the data processing device 16 in FIG. 1) detects the biometric information and the disease information is input. Acquisition means (for example, the input unit 256 in FIG. 10) for acquiring a user ID for identifying the patient), a board ID, and an encryption key (for example, the password in FIG. 18) for encrypting the board ID, and encryption The encryption means for encrypting the board ID based on the encryption key (for example, the encryption unit 351 in FIG. 18), and the transmission of the user ID and the encrypted board ID addressed to the information providing apparatus via the network Control And a second communication control means (for example, the communication unit 259 in FIG. 10), and the information providing apparatus receives the detection information, the board ID, and the state information transmitted from the inspection apparatus, and information processing. Third communication control means (for example, the communication unit 209 in FIG. 9) for controlling reception of the user ID and the encrypted board ID transmitted from the apparatus, detection information corresponding to the board ID, and First record management means (for example, the database management system 303 in FIG. 12) for managing status information records, and second record management for managing records of encrypted board IDs corresponding to user IDs Means (for example, database management system 354 of FIG. 18).

  The second record management means of the information providing apparatus of the inspection system is an encrypted information recorded corresponding to the user ID when a request for the board ID is transmitted together with the user ID from the information processing apparatus. The third communication control means of the information providing apparatus controls the reading of the encrypted board ID addressed to the information processing apparatus via the network (for example, the process of step S2202 in FIG. 21). The transmission is controlled (for example, the process of step S2203 in FIG. 21), and the second communication control unit of the information processing apparatus controls reception of the encrypted board ID transmitted from the information providing apparatus ( For example, the information processing apparatus may further include a decryption unit (for example, the decryption unit 352 in FIG. 18) for decrypting the encrypted board ID with the encryption key. Can.

  The first record management means of the information providing apparatus of the inspection system reads out the detection information recorded corresponding to the board ID when a request for detection information is transmitted together with the board ID from the information processing apparatus. (For example, the process of step S2205 in FIG. 21), the third communication control unit of the information providing apparatus controls transmission of detection information addressed to the information processing apparatus via the network (for example, in FIG. 21). In step S2206, the second communication control unit of the information processing apparatus controls reception of the detection information transmitted from the information providing apparatus (for example, step S3207 in FIG. 21). it can.

  According to the present invention, an inspection apparatus is provided. The test apparatus of the present invention (for example, the bioassay apparatus 12 of FIG. 1) includes a detection substance (for example, the probe of FIG. 5) and a target substance (for example, a nucleotide chain) on a substrate (for example, the bioassay board 11 of FIG. 1). ) Detecting means (for example, excitation light detecting unit 73 in FIG. 6), and reading means for reading the substrate ID from the substrate (for example, excitation light detecting unit 73 and recording / reproducing unit 75 in FIG. 6); Via acquisition means (for example, the input unit 79 in FIG. 6) for acquiring state information (for example, medical condition information) related to the user's state corresponding to the user's operation, and a network (for example, the Internet 14 in FIG. 1). A transmission control hand for controlling transmission of detection information (for example, biological information) indicating the result of detection of the target substance, substrate ID, and status information to another device (for example, the server 15 in FIG. 1) (For example, the network interface 77 of FIG. 6).

  According to the present invention, an inspection method is provided. This test method of the present invention includes a detection step (for example, detecting a binding between a detection substance (for example, the probe in FIG. 5) and a target substance (for example, a nucleotide chain) on a substrate (for example, the bioassay substrate 11 in FIG. 1). , Processing in step S1006 in FIG. 14), reading step for reading out the substrate ID from the substrate (for example, processing in step S1008 in FIG. 14), and status information (for example, medical condition) corresponding to the user's operation. Information) (for example, processing in step S1009 in FIG. 14) and detection information (for example, biological information) indicating the detection result of the target substance via the network (for example, the Internet 14 in FIG. 1). , Board ID, and transmission control step for controlling transmission of status information to other devices (for example, the server 15 in FIG. 1) (for example, For example, the process of step S1010 in FIG.

  According to the present invention, a program is provided. This program (for example, an inspection processing program) detects a binding between a detection substance (for example, the probe in FIG. 5) and a target substance (for example, a nucleotide chain) on a substrate (for example, the bioassay substrate 11 in FIG. 1). Step (for example, the process of step S1006 in FIG. 14), a reading step for reading the substrate ID from the substrate (for example, the process of step S1008 in FIG. 14), and status information regarding the user's state corresponding to the user's operation ( For example, detection information (for example, the result of detection of a target substance via an acquisition step (for example, the process of step S1009 in FIG. 14) for acquiring disease state information) and a network (for example, the Internet 14 in FIG. 1) (for example, (Biological information), substrate ID, and status information are transmitted to other devices (for example, the server 15 in FIG. 1). Transmission control step (for example, the process of step S1010 in FIG. 14).

  This program can be recorded on a recording medium (for example, the magnetic disk 81 in FIG. 6).

  According to the present invention, an information processing apparatus is provided. This information processing apparatus (for example, the data processing apparatus 16 in FIG. 1) specifies a user ID that identifies a user (for example, a patient whose biological information is detected and disease information is input), and a target substance (for example, a nucleotide chain). A substrate ID for specifying a substrate (for example, the bioassay substrate 11 in FIG. 1) on which a detection substance (for example, the probe in FIG. 5) to be detected is arranged, and an encryption key (for example, FIG. 5) 18 acquisition unit (for example, the input unit 256 in FIG. 10), an encryption unit for encrypting the board ID based on the encryption key (for example, the encryption unit 351 in FIG. 18), User ID and encrypted board ID addressed to other devices (eg, server 15 of FIG. 1) that record and provide board inspection results over a network (eg, Internet 14 of FIG. 1) Send Including control to the communication control means (e.g., the communication unit 259 of FIG. 10) and.

  The communication control means further transmits a request for the board ID together with the user ID to the other apparatus via the network, and communicates so as to receive the encrypted board ID transmitted from the other apparatus. (For example, the process in step S3202 and the process in step S3203 in FIG. 21), and the received decryption means for decrypting the encrypted board ID with the encryption key (for example, the decryption unit in FIG. 18) 352) may be further provided.

  Furthermore, the communication control means transmits a request for detection information (for example, biological information) indicating the detection result of the target substance to the other apparatus via the network together with the substrate ID (for example, step S3206 in FIG. 21). The communication can be controlled so that the detection information transmitted from another apparatus is received (for example, the process of step S3207).

  According to the present invention, an information processing method is provided. In this information processing method, a user ID that identifies a user (for example, a patient for whom biological information is detected and disease information is input), a detection material that detects a target substance (for example, a nucleotide chain) (for example, the probe in FIG. 5). ) To obtain a substrate ID for specifying the substrate (for example, the bioassay substrate 11 in FIG. 1) and an encryption key (for example, the password in FIG. 18) for encrypting the substrate ID (for example, password). 19, the processing of steps S3101 to S3103 in FIG. 19, the encryption step for encrypting the board ID based on the encryption key (for example, the processing of step S3104 in FIG. 19), and the network (for example, in FIG. 1). User ID and encrypted addressed to other devices (eg, server 15 of FIG. 1) that record and provide board inspection results via the Internet 14) Communication control step (for example, the process of step S3105 in FIG. 19) for controlling the transmission of the board ID that

  According to the present invention, a program is provided. This program includes a user ID that identifies a user (for example, a patient for whom biological information is detected and disease information is input), and a detection material (for example, the probe in FIG. 5) that detects a target substance (for example, a nucleotide chain). An acquisition step (eg, FIG. 18) that obtains a substrate ID that identifies the placed substrate (eg, bioassay substrate 11 of FIG. 1) and an encryption key (eg, password of FIG. 18) for encrypting the substrate ID. 19 steps S3101 to S3103), an encryption step for encrypting the board ID based on the encryption key (for example, step S3104 in FIG. 19), and a network (for example, the Internet 14 in FIG. 1). ) To other devices (eg, server 15 in FIG. 1) that record and provide board inspection results via Communication control step (for example, the process of step S3105 in FIG. 19) for controlling the transmission of the board ID.

  This program can be recorded on a recording medium (for example, the magnetic disk 281 in FIG. 10).

  According to the present invention, an information providing apparatus is provided. This information providing apparatus (for example, the server 15 in FIG. 1) is a substrate (for example, the bioassay substrate in FIG. 1) on which a detection substance (for example, the probe in FIG. 5) for detecting a target substance (for example, a nucleotide chain) is arranged. 11) from an inspection device (for example, the bioassay device 12 in FIG. 1) that inspects a substrate on which a substrate ID that identifies itself (for example, a substrate ID recorded in the recording area 32) is recorded. Received detection information (for example, biological information) indicating the result of detection of the binding between the detection substance and the target substance on the substrate, the substrate ID, and the state information (for example, medical condition information) regarding the user state, and Communication control means for controlling the reception of the user ID and the encrypted board ID transmitted from another device (for example, the data processing device 16 in FIG. 1) (for example, the communication in FIG. 9). Unit 209), first recording management means (for example, database management system 303 in FIG. 12) that manages detection information and status information recording corresponding to the substrate ID, and encryption corresponding to the user ID Second record management means (for example, the database management system 354 in FIG. 18) for managing the record of the substrate ID being recorded.

  The second record management means controls reading of the encrypted board ID recorded corresponding to the user ID when a request for the board ID is transmitted together with the user ID from another apparatus. However, the communication control means controls the transmission of the encrypted board ID addressed to another device via the network (for example, the Internet 14 in FIG. 1) (for example, the process in step S2202 in FIG. 21) ( For example, the processing in step S2203 in FIG. 21 can be performed.

  When a request for detection information is transmitted together with the substrate ID from another apparatus, the first record management unit controls reading of the detection information recorded corresponding to the substrate ID (for example, FIG. 21), the communication control means can control the transmission of the detection information addressed to other devices via the network (for example, the process of step S2206 in FIG. 21).

  The information providing apparatus can further include an analysis unit (for example, the analysis unit 305 in FIG. 12) that analyzes the relationship between the recorded detection information and state information.

  When a request for an analysis result is transmitted from another device, the first record management unit stores the analysis result related to the detection information (for example, the analysis result recorded in the analysis result list 306 in FIG. 12). The communication control unit controls the reading (for example, the process of step S2208 in FIG. 22), and the communication control unit controls the transmission of the analysis result addressed to another apparatus via the network (for example, the process of step S2209 in FIG. 22). Can be.

  The first record management unit controls reading of the analysis result related to the detection information recorded corresponding to the substrate ID when a request for the analysis result is transmitted together with the substrate ID from another apparatus. (For example, the process of step S2208 in FIG. 22) can be performed.

  According to the present invention, an information providing method is provided. This information providing method is a substrate (for example, the bioassay substrate 11 in FIG. 1) on which a detection substance (for example, the probe in FIG. 5) for detecting a target substance (for example, a nucleotide chain) is disposed, Detected substance on the substrate transmitted from the inspection device (for example, the bioassay device 12 in FIG. 1) for inspecting the substrate on which the specified substrate ID (for example, the substrate ID recorded in the recording area 32) is recorded Detection information (for example, biological information) indicating the result of detection of the binding between the target substance and the substrate, and reception of state information (for example, medical condition information) regarding the user ID, and other devices (for example, FIG. 1) Communication control step (for example, step S2001 in FIG. 14 and FIG. 14) for controlling reception of the user ID and the encrypted board ID transmitted from the data processing device 16). 19 in step S2101), a first record management step (for example, step S2002 in FIG. 14) for managing detection information and status information recording corresponding to the substrate ID, and a user ID. And a second record management step (for example, the process of step S2105 in FIG. 19) for managing the record of the encrypted substrate ID.

  According to the present invention, a program is provided. This program is a substrate (for example, the bioassay substrate 11 in FIG. 1) on which a detection substance (for example, the probe in FIG. 5) for detecting a target substance (for example, a nucleotide chain) is arranged, and identifies itself. Detected substance and target on substrate transmitted from inspection device (for example, bioassay device 12 in FIG. 1) for inspecting the substrate on which substrate ID (for example, substrate ID recorded in recording area 32) is recorded Reception of detection information (for example, biological information) indicating the result of detection of binding to the substance, substrate ID, and state information (for example, medical condition information) regarding the user's state, and other devices (for example, data processing in FIG. 1) Communication control step (for example, step S2001 in FIG. 14 and FIG. 1) for controlling reception of the user ID and the encrypted board ID transmitted from the apparatus 16). 9 in step S2101), a first record management step (for example, step S2002 in FIG. 14) for managing the recording of detection information and state information corresponding to the substrate ID, and a user ID. And a second record management step (for example, the process of step S2105 in FIG. 19) for managing the record of the encrypted substrate ID.

  This program can be recorded on a recording medium (for example, the magnetic disk 231 in FIG. 9).

  The inspection system according to the present invention manages, analyzes, and stores biological information analysis results using a DNA chip that is a particularly useful bioassay tool in the field of bioinformatics. More specifically, the test system according to the present invention causes a hybridization reaction by, for example, dropping a solution containing a target nucleotide chain onto a substrate surface portion on which a detection nucleotide chain (probe) is held, Read and analyze the reaction result of fluorescence developed using excitation light, save the read result (biological information) on the server while protecting privacy, analyze a large number of the stored biological information, and create new biological information Compare the analysis results.

  FIG. 1 is a block diagram showing a configuration of an embodiment of an inspection system according to the present invention.

  The inspection system 1 includes a bioassay substrate 11 and a bioassay device 12. The bioassay device 12 of the test system 1 is connected to the server 15 via the network 13 and the Internet 14.

  Here, the bioassay broadly means a biochemical analysis based on hybridization and other interactions between substances.

  Further, the inspection system 1 includes a data processing device 16. The data processing device 16 is connected to the server 15 via the network 13 and the Internet 14.

  The bioassay substrate 11 has at least a detection substance (for example, a nucleotide chain, a peptide, a protein, a lipid, a low molecular weight compound, a ribosome, or other biological substance) and a target substance on a disc-like substrate that is optically accessible. An area for a hybridization reaction is provided.

  Here, the nucleotide chain that constitutes the detection substance or target substance means a polymer of a phosphate ester of a nucleotide in which a purine or pyrimidine base and a sugar are glycosidically bonded, and includes an oligonucleotide, a polynucleotide, a purine nucleotide, and a DNA probe. Widely includes DNA (full length or a fragment thereof) obtained by polymerizing pyrimidine nucleotides, cDNA obtained by reverse transcription (cDNA probe), RNA and the like.

  That is, a detection substance for detecting a target substance is fixed to the bioassay substrate 11. The bioassay substrate 11 is provided with an area for recording electromagnetic information. In the area for recording the electromagnetic information of the bioassay substrate 11, for example, identification information for identifying the individual bioassay substrate 11 is recorded.

  The bioassay device 12 detects the target substance and detection substance that have reacted (bound). For example, the bioassay device 12 detects a detection substance that is fixed to the bioassay substrate 11 and reacts with a target substance. The bioassay device 12 generates information based on the detected (bound) target substance and detected substance detected. The bioassay device 12 records predetermined information in an area for recording electromagnetic information on the bioassay substrate 11. The bioassay device 12 reads information recorded in an area for recording electromagnetic information of the bioassay substrate 11.

  The bioassay device 12 is connected to the server 15 via the network 13 and the Internet 14, and transmits various types of information to the server 15, or receives and acquires various types of information from the server 15.

  The server 15 records various types of information supplied from the bioassay device 12 or the data processing device 16. When requested by the bioassay device 12 or the data processing device 16, the bioassay is performed via the network 13 and the Internet 14. Information recorded in the device 12 or the data processing device 16 is provided. The server 15 analyzes the recorded information and records the result. When requested by the data processing device 16, the analysis recorded in the data processing device 16 via the network 13 and the Internet 14 is performed. To provide the results.

  The data processing device 16 is connected to the server 15 via the network 13 and the Internet 14 and transmits various types of information to the server 15 or receives and acquires various types of information from the server 15.

  Next, the bioassay substrate 11 will be described.

  FIG. 2 schematically shows an upper surface (FIG. 2A) and a cross section (FIG. 2B) of the bioassay substrate 11.

  The bioassay substrate 11 is formed from a base material used for a disk substrate (disc) used for an optical information recording medium such as CD (Compact Disc), DVD (Digital Versatile Disc), MD (Mini-Disc) (trademark). ing.

  The bioassay substrate 11 is formed into a disk shape from a synthetic resin that can be formed into a disk shape such as quartz glass, silicon, polycarbonate, polystyrene, or the like, preferably a synthetic resin that can be injection molded. In addition, by using an inexpensive synthetic resin substrate, a low running cost can be realized as compared with a conventional glass chip.

  For example, the bioassay substrate 11 has a flat plate shape with a main surface similar to that of an optical disk such as a CD or DVD. A center hole 31 is formed at the center of the bioassay substrate 11. A chucking mechanism for holding and rotating the bioassay substrate 11 is inserted into the center hole 31 when the bioassay substrate 11 is mounted on the bioassay device 12.

  The circular main surface of the bioassay substrate 11 is divided into two regions, a recording region 32 and a reaction region 33 formed concentrically in the radial direction, as shown in FIG. 2A. In the example shown in FIG. 2, the recording area 32 is located on the inner circumference side, and the reaction area 33 is located on the outer circumference side. The recording area 32 may be positioned on the outer peripheral side, and the reaction area 33 may be positioned on the inner peripheral side.

  The recording area 32 is an area where information is optically recorded by irradiating a laser, like an optical disk as an information recording medium. In the recording area 32, a substrate ID (Identifier) that is an identifier for identifying each bioassay substrate 11 is recorded in advance. Information recorded in the recording area 32 is read out by the bioassay device 12.

  In order to manage information for each bioassay substrate 11, a unique substrate ID for the bioassay substrate 11 is assigned and written differently for each bioassay substrate 11, so that the detected gene information is managed by the substrate ID. Will be able to.

  Of course, not only the substrate ID but also other data can be recorded in the recording area 32 of the bioassay substrate 11.

  The reaction region 33 is a region that serves as a field of interaction between probe DNA (detection substance, detection nucleotide chain) and sample DNA (target substance, target nucleotide chain), specifically, a hybridization reaction field.

  The layer structure of the bioassay substrate 11 is formed of an information layer 34 and a reaction layer 35 as shown in FIG. 2B. Here, it is assumed that the information layer 34 is located in the lower layer and the reaction layer 35 is located in the upper layer. Further, the surface on the reaction layer 35 side of the bioassay substrate 11 is referred to as an upper surface 11a, and the surface on the information layer 34 side is referred to as a lower surface 11b.

  In the information layer 34, a signal recording film 36 is formed in which data is reproduced or recorded / reproduced by irradiating a plane region corresponding to the recording region 32 with a laser such as a pit or a phase change material. The signal recording film 36 can be formed by a disc production method similar to an optical disc such as a CD (Compact Disc) or a DVD (Digital Versatile Disc).

  When the signal recording film 36 is irradiated with laser from the lower surface 11 b side of the bioassay substrate 11, the signal (information) is reproduced or recorded in the bioassay device 12. The information layer 34 is formed of a material that transmits the excitation light and control light irradiated during DNA analysis and the wavelength of fluorescence emitted from the fluorescent labeling agent during DNA analysis. For example, the information layer 34 is formed of a material such as quartz glass, silicon, polycarbonate, or polystyrene. Details of excitation light, control light, and fluorescence will be described later.

  As shown in FIG. 3, the reaction layer 35 is formed from the lower layer side (that is, from the information layer 34 side), the substrate layer 41, the transparent electrode layer 42, the solid-phased layer 43, and the well forming layer 44. It has a layered structure.

  The substrate layer 41 is a material that transmits excitation light and control light, which will be described in detail later, and light having a fluorescence wavelength. For example, the substrate layer 41 is formed of a material such as quartz glass, silicon, polycarbonate, or polystyrene.

  The transparent electrode layer 42 is a layer formed on the substrate layer 41. The transparent electrode layer 42 is formed of a light transmissive and conductive material such as ITO (indium-tin-oxide). The transparent electrode layer 42 is formed and formed on the substrate layer 41 to a thickness of about 250 nm by, for example, sputtering or electron beam evaporation.

The solid phase layer 43 is a layer formed on the transparent electrode layer 42. The solid phase layer 43 is formed of a material for solidifying one end of the probe DNA. In the present embodiment, the solid phase layer 43 is a layer in which SiO ₂ whose surface can be modified with silane is formed to a thickness of about 50 nm by, for example, sputtering or electron beam evaporation.

  The well formation layer 44 is a layer formed on the solid phase layer 43. The well formation layer 44 is a layer that forms a plurality of wells 37 that cause a hybridization reaction between the probe DNA and the sample DNA. The well 37 has a hollow shape in which the upper surface 11a of the bioassay substrate 11 is opened, and has a depth and size that can hold the solution when a solution containing sample DNA is dropped. It has become. For example, the well 37 has an opening of 100 μm square, a depth of about 5 μm, and the solid phase layer 43 is exposed on the bottom surface 14. Such a well forming layer 44 is formed by, for example, applying a photosensitive polymer to a thickness of about 5 μm on the solid phase layer 43 by spin coating or the like, and using the photomask in a predetermined pattern. It is formed by exposure and development.

Furthermore, the bottom surface 45 of the well 37 is modified with the functional group so that the probe DNA whose one end is modified with the functional group is bonded to the bottom surface 45 (the portion where the solid-phased layer 43 is exposed). For example, as shown in FIG. 4, the well 37 has a bottom surface 45 (a solid-phased layer 43 formed of SiO ₂ ) modified with a silane molecule 52 having an OH group 51. For this reason, for example, probe DNA whose one end is modified with an NCO group can be bound to the bottom surface 45 of the well 37. Thus, in the bioassay substrate 11, one end of the probe DNA can be bound to the bottom surface 45 of the well 37. Therefore, as shown in FIG. 5, the probe DNA ( P) can be combined.

  In the bioassay substrate 11, as shown in FIG. 2, a plurality of wells 37 are arranged at equal intervals, for example, at intervals of about 400 μm, on a plurality of rows radially extending from the center of the main surface to the outer circumferential direction. Has been placed. However, here, the planar region in which the well 37 is formed is the range of the reaction region 33.

  The bioassay substrate 11 is formed with address pits 38 that can be read by irradiating a laser from the lower surface 11 b side of the bioassay substrate 11. The address pit 38 is a pit for specifying the position of each well 37 on the plane of the bioassay substrate 11, and the bioassay device 12 optically reads the information from the address pit 38, so that the bioassay apparatus 12 corresponds to the corresponding well 37. Get information that identifies That is, by optically reading information from the address pits 38, it is possible to specify which one of the plurality of wells 37 is one well 37 at the position where the laser is currently irradiated. By providing such address pits 38, it is possible to control the dropping position of the solution by a dropping apparatus, which will be described later, and to specify the fluorescence detection position by the objective lens.

  Since the bioassay substrate 11 as described above is formed in a disc shape, by using a reproduction system similar to the optical disc system, focusing servo control for controlling the laser focusing position, and laser in the radial direction are used. Positioning servo control for controlling the irradiation position and the dropping position by the dropping device, and information detection processing of the address pit 38 can be performed. That is, the information content recorded in the address pit 38 and the well 37 in the vicinity of the address pit 38 are made to correspond to each other, so that the information in the address pit 38 is read, so that the specific one well 37 can be read. The position of the well 37 where the fluorescence is emitted by irradiating the laser only is specified, or the position of the specific one well 37 and the relative position between the dropping device are controlled, and the specific one well 37 is controlled. The solution can be dropped on the surface.

  Further, the bioassay substrate 11 is formed with a signal recording film 36 for recording and reproducing various kinds of information in the same manner as an optical disk, together with a region (well 37) for causing a mutual reaction between bioassay substances. In addition, the substrate formed in a disk shape can be used more usefully and variously.

  For example, on the bioassay substrate 11, “information related to operation control of the bioassay substrate 11”, “information related to probe DNA immobilized on the well 37”, “information related to test results”, “information related to readout image”, “Network diagram related to detected gene”, “URL related to detected gene” and the like can be recorded.

  Specific examples of information relating to operation control of the bioassay substrate 11 include, for example, a test program for analyzing DNA using the bioassay substrate 11, various data necessary for the test, update information of the test program, bioassay An instruction manual for the substrate 11 and the analysis apparatus, a procedure for inspection processing, and the like are recorded.

  By recording the information related to the operation control of the bioassay substrate 11 on the same substrate together with the region causing the mutual reaction between the substances, the information related to the operation control is recorded and distributed on another recording medium. There is no need.

  Further, as specific examples of information related to the probe DNA immobilized on the well 37, the type and location of the probe DNA arranged in each well 37, the description of the probe DNA in each well 37, the probe DNA and The relationship with the disease, the manufacturer of the bioassay substrate 11, the date and time of manufacture, etc. are recorded.

  By recording information on the probe DNA immobilized on the well 37 on the same substrate on which the probe DNA is immobilized, the bioassay substrate 11 can be managed reliably and easily. It becomes possible.

  In addition, specific examples of information on test results include information on the subject (name, age, gender, etc.), test date, test location, tester, test result data (raw data read from the reaction area), and test results. Based on the DNA analysis result (visual test result data, data indicating the association with the disease, etc.), past test results of the subject (test history), other test results of the subject, etc. are recorded .

  Further, as a specific example of the information related to the read image, the fluorescence intensity due to the hybridization reaction is captured by a CCD camera or the like, and the image image is recorded in a predetermined format (for example, JPEG (Joint Photographic Experts Group) method). This not only eliminates the need to read the fluorescence intensity from the bioassay substrate 11 once used for detection, but also reduces measurement errors due to deterioration of the fluorescence intensity over time.

  Further, regarding the network diagram relating to the detected gene, for example, the Pathway diagram in KEGG (Kyoto Encyclopedia of Genes and Genomes) can be mentioned. Furthermore, URL (Uniform Resource Locator) address data relating to the gene to be detected can be registered, and information search can be performed using the network interface provided in the bioassay device 12.

  By recording such information on the test result on the same bioassay substrate 11 on which the sample DNA that is the source of the test result is hybridized, the test result can be handled reliably and easily.

  The bioassay substrate 11 is not limited to the above information, and other data can also be recorded.

  In the bioassay substrate 11, the main surface is divided into two areas, a recording area 32 and a reaction area 33, but the recording area 32 and the reaction area 33 may overlap on a plane area. In this case, the position of the signal recording film 36 in the thickness direction from the reaction region 33 is irradiated with laser (excitation light described in detail later) or control laser (control light described in detail later) to excite fluorescence. What is necessary is just to be formed in the position spaced apart from the focal depth. That is, if the signal recording film 36 is positioned in front of the focus as in the case of the two-layer recording of the optical disc, the reaction region 33 is sufficiently reached.

  Further, the bottom surface 45 is an example of a detection surface, and the detection surface means a surface portion subjected to a suitable surface treatment that can fix the end of a nucleotide chain by a coupling reaction or other chemical bonds, and is interpreted narrowly. Not. For example, in the case of a detection surface surface-treated with streptavidin, it is suitable for immobilizing a biotinylated nucleotide chain. Alternatively, if a magnetic bead is attached to the end of the nucleotide chain and the nucleotide chain is temporarily fixed with a magnet or the like from the back surface, there is no need for special surface treatment.

  The well 37 is an example of a reaction region, and the reaction region is a partitioned region or space that can provide a place for a hybridization reaction in a liquid phase.

  In this reaction region, protein-protein, nucleotide chain-nucleotide chain (including both DNA-DNA, DNA-RNA, and RNA-RNA), protein, within the range that matches the object and effect of the present invention. -Reactions such as interaction between nucleotide chains (including double strands) and other macromolecules, interaction between macromolecules and small molecules, and interactions between small molecules can be caused.

  For example, when a double-stranded nucleotide is used, the binding between a receptor molecule such as a hormone receptor that is a transcription factor and a response element DNA portion can be analyzed.

  In the bioassay substrate 11 according to the present invention, the above-mentioned “reaction region” is a well reaction portion having a well structure in which a detection surface is formed on one wall surface, and a plurality of the well reaction portions are arranged on a disk-shaped substrate. Can be adopted. The “well reaction part” is defined as a part having a reaction region in a small chamber shape separated from the peripheral substrate region.

  This “well reaction part” can be arranged at an appropriate position on the substrate. However, if the “well reaction part” is arranged side by side so as to exhibit a radial shape when viewed from above, the space on the substrate can be used effectively. The integration density can be increased. That is, it is possible to provide a (disc-shaped) DNA chip with a large amount of recording information.

  In addition, since the well reaction parts are partitioned so as not to be contaminated with each other, different detection nucleotide chains are fixed in each well detection part unit or a plurality of grouped well detection part units, and are separately provided for each detection nucleotide chain. Independent conditions can be set to allow the hybridization reaction to proceed.

  For example, marker genes for disease onset can be grouped and fixed on a substrate. Thereby, the expression status of a plurality of diseases can be confirmed simultaneously using one substrate.

  Further, based on the difference in melting temperature Tm (Melting Temperature) or GC (Guanine-Cytosine) content, it becomes possible to group the nucleotide chains for detection to be immobilized. This makes it possible to finely select the buffer composition, concentration and other reaction conditions for obtaining an active hybridization reaction, washing conditions, sample solution concentration to be dropped, etc., depending on the nature of the nucleotide chain for detection. The risk of showing false positives or false negatives in the analysis work can be greatly reduced.

  In this way, the bioassay substrate 11 has at least a detection substance (for example, a nucleotide chain, a peptide, a protein, a lipid, a low molecular weight compound, a ribosome, or other biological substance) on the optically accessible disk-like substrate. A reaction unit (for example, well 37) having a reaction region that serves as a field for a hybridization reaction with a target substance, and a recording unit (for example, a magneto-optical disk that records an ID unique to each bioassay substrate 11) , A recording area 32).

  In addition, the recording section of the bioassay substrate 11 is configured such that the magneto-optical disk is opposite to the surface where the reaction region exists so that the ID unique to each bioassay substrate 11 can be written. The recording unit may be rewritable, can be written only once, or may be on the same surface as the reaction area.

  Next, a bioassay device 12 that performs DNA analysis using the above-described bioassay substrate 11 will be described with reference to FIG.

  As shown in FIG. 6, the bioassay device 12 holds the bioassay substrate 11 and rotates the disc loading unit 71, stores various solutions for hybridization, and stores in the well 37 of the bioassay substrate 11. A dropping unit 72 for dropping the solution, an excitation light detecting unit 73 for detecting excitation light from the well 37 of the bioassay substrate 11, a control / servo unit 74 for managing and controlling each unit, and the bioassay substrate 11 The signal recording film 36 includes a recording / reproducing unit 75 that records and reproduces signals.

  Further, the bioassay device 12 controls the network interface 77 for connecting to the Internet 14 via the network 13 and the recording / reproducing unit 75 and the network interface 77 to process and generate predetermined data to generate the bioassay substrate 11. And a control unit 76 for recording information and reading information.

  Furthermore, the bioassay device 12 includes a display unit 78 that displays predetermined characters or images based on the control of the control unit 76. The display unit 78 includes, for example, an LCD (Liquid Crystal Display) or an organic EL (Electro Luminescence) display.

  The input unit 79 includes a keyboard, a mouse, a button, a switch, a barcode scanner, or the like, and supplies a signal corresponding to a user operation to the control unit 76. For example, by using the input unit 79, information related to a disease, such as a disease symptom and a disease name, a change in appearance of a patient, a blood test result, a diagnosis result, or a user (patient) ID, an encryption / concealment code ( Password).

  A drive 80 is connected to the controller 76 as necessary. The drive 80 reads a program recorded in the mounted magnetic disk 81, optical disk 82, magneto-optical disk 83, or semiconductor memory 84, and supplies the read program to the control unit 76. Accordingly, the control unit 76 can execute a program recorded in the magnetic disk 81, the optical disk 82, the magneto-optical disk 83, or the semiconductor memory 84, which is an example of a recording medium.

  Further, the control unit 76 is provided with a determination unit 85 and a measurement operation control unit 86. The determination unit 85 compares various types of information, and executes processing for determining whether the information matches. The measurement operation control unit 86 controls the recording / reproducing unit 75 and the like to control the measurement operation of the bioassay device 12.

  The disc loading unit 71 is inserted into the center hole 31 of the bioassay substrate 11 and holds the bioassay substrate 11 mounted thereon, and the bioassay substrate 11 is driven by driving the chucking mechanism 91. And a spindle motor 92 for rotating the motor. The disc loading unit 71 rotationally drives the bioassay substrate 11 while holding the bioassay substrate 11 horizontally such that the upper surface 11a side is in the upward direction.

  The dropping unit 72 includes a storage unit 93 that stores the sample solution S, and a dropping head 94 that drops the sample solution S in the storage unit 93 onto the bioassay substrate 11. The drip head 94 is disposed above the upper surface 11a of the bioassay substrate 11 loaded horizontally. Further, the dropping head 94 controls the relative position with the bioassay substrate 11 in the radial direction based on the position information and rotation synchronization information read from the address pits 38 of the bioassay substrate 11 shown in FIG. The sample solution S containing the sample DNA or the fluorescent labeling agent is configured to drop following the predetermined well 37 accurately.

  The excitation light detection unit 73 has an optical head 101. The optical head 101 is disposed on the lower side of the horizontally loaded bioassay substrate 11, that is, on the lower surface 11b side. The optical head 101 is movable in the radial direction of the bioassay substrate 11 by, for example, a thread mechanism (not shown).

  The optical head 101 includes an objective lens 102, a biaxial actuator 103 that supports the objective lens 102 so as to be movable, and a light guide mirror 104. The objective lens 102 is supported by the biaxial actuator 103 so that the central axis thereof is substantially perpendicular to the surface of the bioassay substrate 11. Accordingly, the objective lens 102 can collect the light beam incident from the lower side of the bioassay substrate 11 on the bioassay substrate 11 to which the objective lens 102 is attached. The biaxial actuator 103 supports the objective lens 102 so as to be movable in two directions perpendicular to the surface of the bioassay substrate 11 and in the radial direction of the bioassay substrate 11. By driving the biaxial actuator 103, the focal point of the light collected by the objective lens 102 can be moved in the direction perpendicular to the surface of the bioassay substrate 11 and in the radial direction. Therefore, the optical head 101 can perform the same control as the focus control and positioning control in the optical disc system.

  The light guide mirror 104 is disposed at an angle of 45 ° with respect to the optical path X. The optical path X is an optical path through which the excitation light P, fluorescence F, control light V, and reflected light R enter and exit the optical head 101. Excitation light P and control light V are incident on the light guide mirror 104 from the optical path X. The light guide mirror 104 reflects the excitation light P and the control light V, refracts 90 °, and enters the objective lens 102. The excitation light P and the control light V incident on the objective lens 102 are collected by the objective lens 102 and applied to the bioassay substrate 11. In addition, the fluorescent light F and the reflected light R of the control light V are incident on the light guide mirror 104 from the bioassay substrate 11 through the objective lens 102. The light guide mirror 104 reflects the fluorescent light F and the reflected light R, refracts them 90 °, and emits them onto the optical path X. A driving signal for moving the optical head 101 by a sled and a driving signal for driving the biaxial actuator 103 are supplied from the control / servo unit 74.

  The excitation light detection unit 73 also includes an excitation light source 105 that emits the excitation light P, a collimator lens 106 that converts the excitation light P emitted from the excitation light source 105 into a parallel light beam, and an excitation light that has been converted into a parallel light beam by the collimator lens 106. A first dichroic mirror 107 that refracts the light P on the optical path X and irradiates the light guide mirror 104;

  The excitation light source 105 is a light source that emits a laser having a wavelength capable of exciting the fluorescent labeling agent. The excitation light P emitted from the excitation light source 105 is, for example, a laser having a wavelength of 405 nm. The wavelength of the excitation light P may be any wavelength as long as it can excite the fluorescent labeling agent. The collimator lens 106 converts the excitation light P emitted from the excitation light source 105 into a parallel light beam. The first dichroic mirror 107 is a reflecting mirror having wavelength selectivity, reflects only the light having the wavelength of the excitation light P, and transmits the light having the wavelength of the fluorescence F and the control light V (its reflected light R). To do. The first dichroic mirror 107 is inserted on the optical path X with an angle of 45 °, reflects the excitation light P emitted from the collimator lens 106 and refracts it by 90 °, and excites the light guide mirror 104. Irradiate light P.

  The excitation light detection unit 73 refracts the fluorescence F emitted from the optical head 101 onto the optical path X by the avalanche photodiode 108 that detects the fluorescence F, the condensing lens 109 that collects the fluorescence F, and the like. And a second dichroic mirror 110 for irradiating the avalanche photodiode 108.

  The avalanche photodiode 108 is a very sensitive photodetector, and can detect the fluorescent light F with a weak light amount. The wavelength of the fluorescence F detected by the avalanche photodiode 108 is about 470 nm here. Further, the wavelength of the fluorescence F varies depending on the type of the fluorescent labeling agent. The condensing lens 109 is a lens for condensing the fluorescence F on the avalanche photodiode 108. The second dichroic mirror 110 is inserted at an angle of 45 ° on the optical path X, and is disposed downstream of the first dichroic mirror 107 when viewed from the light guide mirror 104 side. Therefore, the fluorescence F, the control light V, and the reflected light R are incident on the second dichroic mirror 110, and the excitation light P is not incident. The second dichroic mirror 110 is a reflecting mirror having wavelength selectivity, reflects only the light having the wavelength of the fluorescence F, and transmits the light having the wavelength of the control light (reflected light R). The second dichroic mirror 110 reflects and refracts the fluorescence F emitted from the light guide mirror 104 of the optical head 101, and irradiates the avalanche photodiode 108 with the fluorescence F via the condenser lens 109. .

  The avalanche photodiode 108 generates a signal corresponding to the light amount of the fluorescence F thus detected, and supplies the generated signal to the control / servo unit 74.

  The excitation light detection unit 73 detects the control light source 111 that emits the control light V, the collimator lens 112 that uses the control light V emitted from the control light source 111 as a parallel light flux, and the reflected light R of the control light V. A photodetection circuit 113; a cylindrical lens 114 that causes astigmatism to focus the reflected light R on the photodetection circuit 113; and an optical separator 115 that separates the control light V and the reflected light R. ing.

  The control light source 111 is a light emitting unit having a laser source that emits a laser having a wavelength of 780 nm, for example. The wavelength of the control light V is set to a wavelength at which the address pits 38 can be detected and information can be recorded on and reproduced from the signal recording film 36. Further, the wavelength of the control light V is set to a wavelength different from the wavelengths of the excitation light P and the fluorescence F. As long as such a wavelength is used, the wavelength of the control light V is not limited to 780 nm and may be any wavelength. The collimator lens 112 converts the control light V emitted from the control light source 111 into a parallel light beam. The control light V made into a parallel light beam is incident on the optical separator 115.

  The photodetector circuit 113 generates a detector for detecting the reflected light R, a focus error signal, a positioning error signal, a reproduction signal for the address pit 38, and a reproduction signal for the signal recording film 36 from the detected reflected light R. And a signal generation circuit. Since the reflected light R is light generated by reflecting the control light V with the bioassay substrate 11, the wavelength thereof is 780 nm, which is the same as that of the control light.

  Note that when the optical head 101 irradiates the reaction area 33 (outer peripheral area) of the bioassay substrate 11 with a laser, the focus error signal indicates the focus position of the light collected by the objective lens 102 and the bioassay. The error signal indicates the amount of positional deviation of the substrate 11 from the reaction layer 35, and the positioning error signal is a signal indicating the amount of positional deviation between the position of the predetermined well 37 and the focal position in the disc radial direction. When the laser is irradiated to the recording area 32 (inner peripheral area) of the bioassay substrate 11 by the optical head 101, the focus error signal is obtained by focusing the light focused by the objective lens 102 and the signal recording film. The positioning error signal is a signal indicating the positional deviation amount of the track position and the focal position of the signal recording film 36 in the disc radial direction.

  The reproduction signal of the address pit 38 is detected only when the reaction area 33 (outer peripheral area) is irradiated with laser, and the information content described in the address pit 38 recorded on the bioassay substrate 11 is detected. It is a signal to show. By reading this information content, it is possible to identify the well 37 that is currently irradiating the control light V.

  The reproduction signal of the signal recording film 36 is detected only when the recording area 32 (inner peripheral area) is irradiated with laser, and is a signal indicating the information content recorded on the track of the signal recording film 36. .

  The photodetect circuit 113 supplies the control / servo unit 74 with a focus error signal, a positioning error signal, and a reproduction signal of the address pit 38 generated based on the reflected light R.

  The cylindrical lens 114 is a lens for condensing the reflected light R on the photodetection circuit 113 and causing astigmatism. By generating astigmatism in this way, the focus error signal can be generated by the photo detect circuit 113.

  The optical separator 115 includes a light separation surface 115a made of a deflecting beam splitter and a quarter wavelength plate 115b. In the optical separator 115, light incident from the opposite side of the quarter-wave plate 115b is transmitted through the light separation surface 115a, and when the reflected light of the transmitted light is incident from the quarter-wave plate 115b side, light is transmitted. The separation surface 115a is reflected. The optical separator 115 has a light separation surface 115a inserted at an angle of 45 ° on the optical path X, and is disposed at the rear stage of the second dichroic mirror 110 when viewed from the light guide mirror 104 side. Therefore, the optical separator 115 transmits the control light V emitted from the collimator lens 112 and makes the control light V incident on the light guide mirror 104 in the optical head 101 and guides the optical head 101. The reflected light R emitted from the mirror 104 is reflected and refracted by 90 °, and the reflected light R is applied to the photodetection circuit 113 through the cylindrical lens 114.

  The control / servo unit 74 performs various servo controls based on the focus error signal, the positioning error signal, and the address pit 38 reproduction signal detected by the excitation light detection unit 73.

  When the reaction area 33 (outer peripheral area) is irradiated with a laser, the control / servo unit 74 drives the biaxial actuator 103 in the optical head 101 based on the focus error signal, and the objective lens 102 and the well 37, the biaxial actuator 103 in the optical head 101 is driven based on the positioning error signal to control the radial positional relationship between the objective lens 102 and the well 37, and the address pit 38 is reproduced. Based on the signal, thread movement control of the optical head 101 is performed to move the optical head 101 to a predetermined radial position.

  When the recording area 32 (inner peripheral area) is irradiated with the laser, the control / servo unit 74 drives the biaxial actuator 103 in the optical head 101 based on the focus error signal and the objective lens 102. The distance between the signal recording film 36 is controlled, and the biaxial actuator 103 in the optical head 101 is driven based on the positioning error signal so that the positional relationship in the radial direction between the objective lens 102 and the recording track of the signal recording film 36 is determined. Control.

  The recording / reproducing unit 75 demodulates and decodes the reproduction signal of the data recorded on the signal recording film 36 and outputs the data, and also encodes and modulates the recording data recorded on the signal recording film 36. At the time of reproduction, the recording / reproducing unit 75 receives the reproduction signal output from the excitation light detection unit 73 and outputs the demodulated and decoded data to the outside. In recording, the recording / reproducing unit 75 inputs recording data from the outside, supplies the encoded and modulated data to the excitation light detecting unit 73, and drives the control light source 111 that emits the control light V. .

  The network interface 77 uses the URL (Uniform Resource Locator) type address data recorded in advance in the recording area 32 of the bioassay substrate 11, the address designated by the input unit 79, and the like to connect the network 13 and the Internet 14. The server 15 is accessed.

  The control unit 76 compresses the image image based on the hybridization result read out by the recording / reproducing unit 75 into image data of a predetermined format (for example, JPEG (Joint Photographic Experts Group) system), and passes the recording / reproducing unit 75. To be recorded on the bioassay substrate 11. Further, the control unit 76 controls the network interface 77 to collect related information from the server 15, and similarly records the collected related information. Furthermore, when the bioassay substrate 11 is attached to the bioassay device 12, it is determined from the information recorded on the bioassay substrate 11 whether or not the bioassay substrate 11 has already been used for the test. When it is determined that the substrate 11 has already been used for the inspection, when the written image image or the collected data is displayed or when the bioassay substrate 11 is to be used for the inspection again, the inspection has already been performed. Is displayed on the display unit 78 to limit the measurement operation.

  The bioassay device 12 configured as described above performs the following operation when performing a bioassay.

  While rotating the bioassay substrate 11, the bioassay device 12 drops a solution containing the sample DNA (S) on the well 37 as shown in FIG. 7, and the probe DNA (P) and the sample DNA (S ) Are allowed to interact with each other (hybridization). Further, by dropping a buffer solution containing the fluorescent labeling agent M onto the bioassay substrate 11 that has been subjected to the hybridization treatment, the probe DNA (P) and the sample DNA (S), as shown in FIG. The fluorescent labeling agent M is inserted into the heavy helix.

  In addition, the bioassay device 12 rotates the bioassay substrate 11 after the fluorescent labeling agent is dropped, and makes the excitation light P incident from the lower surface 11b side of the bioassay substrate 11 to irradiate the fluorescent labeling agent in the well 37. Then, the fluorescence F generated from the fluorescent labeling agent in response to the excitation light P is detected from below the bioassay substrate 11.

  Here, the bioassay device 12 irradiates the bioassay substrate 11 with the excitation light P and the control light V through the same objective lens 102. Therefore, the bioassay device 12 can specify the irradiation position of the excitation light P, that is, the emission position of the fluorescence F by performing focus control, positioning control, and address control using the control light V. The probe DNA bound to the sample DNA can be identified from the fluorescence emission position.

  The bioassay device 12 having the above-described configuration performs the following operation when recording and reproducing data.

  The bioassay device 12 stops emitting the excitation light P and emits only the control light V. Then, servo control is performed while the bioassay substrate 11 is rotated, and data is recorded on or reproduced from the tracks on the signal recording film 36.

  As described above, the bioassay device 12 according to the present invention drops the target substance-containing liquid labeled with the fluorescent substance onto the detection substance held on the detection surface of the bioassay substrate 11, so that the detection substance and the target substance are separated. The reaction product is made to react with each other in the reaction region to produce a reaction product, and the fluorescence emitted from the fluorescent target substance by irradiating the reaction product with one or more wavelengths of excitation light is collected from the reaction region of the reaction part. To detect the fluorescence intensity.

  In addition to the case where the target substance is preliminarily fluorescently labeled, the target substance and the fluorescent substance are dripped separately at about the same time or in chronological order when they are mixed at the time of dropping and dropped onto the reaction region. You may make it do. Here, the target substance may be either a means for labeling with a fluorescent dye or a means using an intercalator. The “intercalator” is incorporated into the hybridized double-stranded nucleotide chain so as to be inserted into the hydrogen bond between the bases of the detection nucleotide substance and the target nucleotide substance. As a result, the fluorescence wavelength is shifted to the longer wavelength side compared to the fluorescence wavelength from the double-stranded nucleotide chain not containing the intercalator, and the fluorescence intensity and the amount of intercalator incorporated into the double-stranded nucleotide chain Since there is a correlation between them, quantitative detection is possible based on this correlation.

  The fluorescence intensity or fluorescence distribution image detected by these is analyzed by the control unit 76, and biological information (for example, mutant gene sequence information, SNPs information, expression gene information (presence / absence of mRNA, expression level, localization information)) Is generated.

  In addition, the bioassay device 12 includes an excitation light detection unit 73 that reads the substrate ID recorded in the recording area 32 of the bioassay substrate 11 using a normal optical disk reading technique, and the biological information obtained by analyzing the substrate ID. A network interface 77 is also provided for transmitting and registering to the server 15. Here, the optical disk reading technique is a technique used in CD (Compact Disc), DVD (Digital Versatile Disc), MD (Mini-Disc) (trademark), and the like.

  In addition, the input unit 79 for inputting an onset medical condition may be any one that allows predetermined input, such as selection using a keyboard or mouse, a symptom list with a barcode, and the like. A medical condition is a series of information related to a disease such as a disease name, a change in appearance of a patient, a blood test result, and a diagnosis result.

  The communication unit that transmits the board ID, the medical condition, and the biological information to the server 15 includes a transmission control unit (for example, the network interface 77), a transmission protocol, and a connection path (such as the network 13 or the Internet 14) that can be connected to the server 15. Consists of. The transmission control unit normally uses a general CPU (Central Processing Unit), and the transmission protocol is implemented by a program operating on the CPU. The transmission path may be any transmission path having a function that can be connected to the server 15, such as the Internet 14, a LAN (Local Area Network), a wireless LAN, a telephone line, and other wired / wireless transmission paths.

  Next, the server 15 will be described. The server 15 is composed of, for example, a personal computer or a dedicated server.

  The server 15 is configured as shown in FIG. 9, for example. A CPU (Central Processing Unit) 201 executes various processes according to a program recorded in a ROM (Read Only Memory) 202 or a recording unit 208. A RAM (Random Access Memory) 203 appropriately stores programs executed by the CPU 201 and data. The CPU 201, ROM 202, and RAM 203 are connected to each other via a bus 204.

  An input / output interface 205 is also connected to the CPU 201 via the bus 204. The input / output interface 205 is connected to an input unit 206 including a keyboard, a mouse, and a microphone, and an output unit 207 including a display and a speaker. The CPU 201 executes various processes in response to commands input from the input unit 206. Then, the CPU 201 outputs an image, sound, or the like obtained as a result of the processing to the output unit 207.

  The recording unit 208 connected to the input / output interface 205 includes, for example, a hard disk and records programs executed by the CPU 201 and various data. The communication unit 209 communicates with an external device via the Internet 14 and other networks. In this example, the communication unit 209 functions as a network interface.

  Further, a program may be acquired via the communication unit 209 and recorded in the recording unit 208.

  The drive 210 connected to the input / output interface 205 drives the magnetic disk 231, the optical disk 232, the magneto-optical disk 233, or the semiconductor memory 234 when they are mounted, and programs and data recorded there. Get etc. The acquired program and data are transferred to the recording unit 208 and recorded as necessary.

  Next, the data processing device 16 will be described. The data processing device 16 is configured by, for example, a personal computer or a workstation.

  The data processing device 16 is configured as shown in FIG. 10, for example. The CPU 251 executes various processes according to programs recorded in the ROM 252 or the recording unit 258. The RAM 253 appropriately stores programs executed by the CPU 251 and data. The CPU 251, ROM 252, and RAM 253 are connected to each other via a bus 254.

  An input / output interface 255 is also connected to the CPU 251 via the bus 254. Connected to the input / output interface 255 are an input unit 256 made up of a keyboard, mouse, microphone, and the like, and an output unit 257 made up of a display, a speaker, and the like. The CPU 251 executes various processes in response to commands input from the input unit 256. Then, the CPU 251 outputs an image, sound, or the like obtained as a result of the processing to the output unit 257.

  The recording unit 258 connected to the input / output interface 255 is configured by a hard disk, for example, and records programs executed by the CPU 251 and various data. The communication unit 259 communicates with an external device via the network 13 and the Internet 14. In this example, the communication unit 259 functions as a network interface.

  Alternatively, the program may be acquired via the communication unit 259 and recorded in the recording unit 258.

  The drive 260 connected to the input / output interface 255 drives the magnetic disk 281, the optical disk 282, the magneto-optical disk 283, or the semiconductor memory 284 when they are mounted, and programs and data recorded there. Get etc. The acquired program and data are transferred to the recording unit 258 and recorded as necessary.

  Next, a test process performed by the bioassay device 12 that executes the test process program will be described with reference to the flowchart of FIG.

  Before performing the inspection process, the person performing the inspection must collect DNA from the person to be inspected, and copy the sample DNA, which is the collected DNA, using a technique such as PCR. .

  In step S <b> 11, the user (user) (the person who performs the test) inserts the bioassay substrate 11 into the bioassay device 12. For example, in step S <b> 11, the user horizontally loads the bioassay substrate 11 on the disk loading unit 71 of the bioassay device 12. In step S <b> 12, the inspection processing program reads data necessary for inspection processing, such as information indicating whether or not the bioassay substrate 11 has already been used and tested from the recording area 32 of the bioassay substrate 11.

  In step S13, the test processing program determines whether or not the bioassay substrate 11 that has been mounted has been tested based on the information read in the process of step S12, and has not been tested, that is, has been mounted. Since the test is not performed on the existing bioassay substrate 11, the process proceeds to step S <b> 14, and a sample or a labeling substance is dropped onto the bioassay substrate 11.

  In step S15, since the hybridization is performed on the bioassay substrate 11, in step S16, the test processing program reads out the reaction result from the bioassay substrate 11 and analyzes the reaction result.

  In step S <b> 17, the inspection processing program writes the image data or the analysis result obtained by the processing in step S <b> 16 on the bioassay substrate 11.

  Here, the processing in steps S14 to S17 will be described in detail. The bioassay device 12 rotates the bioassay substrate 11 while performing position control based on the address pits 38, and one end of the bioassay substrate 11 from the dropping head 94 is an NCO group. A solution containing the probe DNA modified with the above is dropped into a predetermined well 37. At this time, a plurality of types of probe DNAs are dropped on one bioassay substrate 11. However, the probe DNA is dropped so that one kind of probe DNA enters one well 37.

  It should be noted that which type of probe DNA is dropped into each well 37 is determined by reading an arrangement map or the like indicating the correspondence between the well 37 and the probe DNA in advance from the signal recording film 36 or via the network interface 77. An arrangement map or the like is collected from the server 15, and the bioassay device 12 performs dropping control based on the arrangement map.

  Subsequently, the bioassay device 12 inserts an electrode into the solution in the well 37 from the upper surface 11 a side of the bioassay substrate 11, and applies an alternating electric field of about 1 MV / m and 1 MHz to each well 37. When the alternating electric field is applied in this manner, the probe DNA extends in the vertical direction with respect to the bioassay substrate 11 and the probe DNA moves in the vertical direction to the bioassay substrate 11 to be subjected to surface modification treatment in advance. On the other hand, the modified end of the probe DNA is bound, and the probe DNA can be immobilized (immobilized) in the well 37. Details of the immobilization of the probe DNA are described in Masao Washizu and Osamu Kurosawa: “Electrostatic Manipulation of DNA in Microfabricated Structures”, IEEE Transaction on Industrial Application Vol.26, No26, P.1165-1172 (1900). .

  Next, the bioassay device 12 drops the solution containing the buffer salt from the dropping head 94 to each well 37 on the bioassay substrate 11 together with the solution containing the buffer salt.

  Then, after the sample DNA is dropped, the bioassay device 12 moves the bioassay substrate 11 to a thermostatic layer or the like, heats the inside of the well 37 to several tens of degrees, and maintains an AC electric field of about 1 MV / m and 1 MHz while being heated. Is applied. When such a process is performed, the sample DNA and the probe DNA extend in the vertical direction so that the steric hindrance is reduced, and the sample DNA moves in the vertical direction with respect to the bioassay substrate 11. As a result, hybridization occurs between sample DNA and probe DNA in the same well 37 and corresponding to each other in base sequence.

  After causing hybridization, the bioassay device 12 drops a fluorescent labeling agent such as an intercalator into the well 37 of the bioassay substrate 11. Such a fluorescent labeling agent enters and binds between the double helix of the probe DNA and the sample DNA that have caused hybridization.

  Then, the bioassay device 12 cleans the surface 1a of the bioassay substrate 11 with pure water or the like, and removes the sample DNA and the fluorescent labeling agent in the well 37 where hybridization has not occurred. As a result, the fluorescent labeling agent remains only in the well 37 where hybridization has occurred.

  In step S16, the bioassay device 12 detects the result of the reaction between the probe and the sample DNA.

  That is, the bioassay device 12 rotates (rotates) the bioassay substrate 11 while performing focus servo control, positioning servo control, and address control on the basis of the control light V, and causes the excitation light P to pass through the predetermined well 37. Irradiate. Along with the irradiation of the excitation light P, whether or not the fluorescence F is generated is detected while detecting address information by the address pits 38.

  In step S17, the bioassay device 12 generates biological information from the sample DNA, the probe, and the result of the reaction. The biological information includes, for example, mutant gene sequence information, SNPs information, or expressed gene information (presence / absence of mRNA, expression level, localization information).

  Expressed gene information refers to mRNA indicating proteins expressed in vivo, reverse transcribed cDNA and its expression level, localization information (generally, gene expression level varies depending on the organ site), mutation Genes that occur, their sequences and loci, polymorphism information, etc.

  In step S <b> 17, the bioassay device 12 calculates a measurement value according to the position of each well 37 on the bioassay substrate 11 and the intensity of emission of the fluorescence F, and the result and the captured image are displayed on the bioassay substrate 11. Recording and storing in the signal recording film 36. Subsequently, the bioassay device 12 determines the presence / absence of the target substance from the measured value, and creates a discrimination map on the disk image. The bioassay device 12 analyzes the base sequence of the sample DNA based on the created map and an arrangement map indicating what kind of base sequence of the probe DNA has been dropped into each well 37.

  The bioassay device 12 may analyze, for example, the relationship with the disease based on the information on the relationship between the probe DNA and the disease recorded on the signal recording film 36 with reference to the result of the analysis.

  Furthermore, the bioassay device 12 may associate the expressed gene with the gene network recorded on the bioassay substrate 11 and illustrate its function.

  Then, the bioassay device 12 records and saves the analysis result, the detected arrangement map, and the like on the signal recording film 36 of the bioassay substrate 11.

  In step S 18, the inspection processing program causes the network interface 77 to connect to the Internet 14 via the network 13. That is, the inspection processing program is connected to the server 15 via the network 13 and the Internet 14.

  In step S19, the inspection processing program selects related information from the server 15 and acquires the related information. In step S <b> 20, the test processing program stores the related information by recording the acquired related information on the bioassay substrate 11.

  Further, in step S20, the test processing program, based on the signal from the input unit 79 corresponding to the user's operation, information on the medical condition (disease name, change in appearance of the patient, blood test result, diagnostic result) Information), the substrate ID is read from the bioassay substrate 11 using the recording / reproducing unit 75, the substrate ID, the analysis result (biological information) of the bioassay substrate 11 and the disease information indicating the disease state via the network interface 77. Is transmitted to the server 15.

  The medical condition includes a healthy condition, and the medical condition information may indicate a healthy condition.

  In step S21, the inspection processing program displays the acquired related information on the display unit 78, and the process ends.

  On the other hand, in step S13, since the test has been performed, that is, the test has already been performed on the mounted bioassay substrate 11, the process proceeds to step S22, and the test processing program executes the process of prohibiting the measurement operation. For example, in step S22, the test processing program sets the flag indicating the prohibition of the measurement operation to set the measurement operation prohibition mode, and the measurement operation is not performed using the attached bioassay substrate 11. Like that.

  In step S <b> 23, the test processing program reads stored data from the recording area 32 of the bioassay substrate 11. In step S24, the inspection processing program displays the read saved data on the display unit 78, proceeds to step S18, and connects to the Internet 14 to execute processing for acquiring related information.

  In the present invention, it has been described that the disc-shaped bioassay substrate 11 using a magneto-optical disk is used. However, the shape of the bioassay substrate 11 is appropriately set to a suitable shape (for example, a square, a rectangle, an ellipse, etc.). You may make it do.

  Further, although an example in which a magneto-optical disk is used as the recording area 32 has been shown, the recording area 32 is not limited to the magneto-optical disk, but an optical disk, a magnetic disk, a magnetic recording tape, a semiconductor memory (EEPROM (EEPROM)) having a predetermined recording function. Electrically Erasable Programmable ROM (FRAM), FRAM (Ferroelectronic RAM), MRAM (Magnetoresistive RAM), etc.), and other technologies such as recording using printing can be used to record data.

  However, in this case, the bioassay substrate 11 used for data detection requires a dedicated device (for example, the bioassay device 12) even at the time of data reading, which is expensive.

  FIG. 12 is a block diagram showing functions of the bioassay device 12 and the server 15 when the bioassay device 12 records the substrate ID, biological information, and medical condition information on the server 15.

  Note that the blocks in FIG. 12 may be configured by software, or may be configured by dedicated hardware.

  The substrate ID reading unit 301 includes an excitation light detecting unit 73 and a recording / reproducing unit 75. The substrate ID reading unit 301 reads the substrate ID from the attached bioassay substrate 11 and supplies it to the network interface 77.

  The substrate ID reading unit 301 reads information from a predetermined region of the recording region 32 of the bioassay substrate 11 by the recording / reproducing unit 75 and extracts a different substrate ID for each bioassay substrate 11. For example, the substrate ID is read out from the recording area 32 of the recording method similar to the CD-R by using an optical disc reading technique.

  Note that a semiconductor memory, a physical scratch, or any other ID that can be used as a board-specific ID may be used, but the board ID reading unit 301 at that time is appropriately changed according to the board ID recording method.

  The excitation light detection unit 73 detects the reaction result from the bioassay substrate 11 and supplies it to the biological information generation unit 302. For example, as described above, the excitation light detection unit 73 extracts the presence / absence of the target substance, the discrimination map on the disk image, the fluorescence intensity, and the like. The excitation light detection unit 73 reads information on a detection substance (for example, a probe) from the bioassay substrate 11 in advance and grasps which part (for example, which well 37) has a substance for detecting which gene is mounted. Therefore, the expression gene name and the expression gene amount can be extracted by analyzing the fluorescence image.

  The biological information generation unit 302 generates biological information from the reaction result supplied from the excitation light detection unit 73 and supplies the biological information to the network interface 77. The biological information includes, for example, expressed gene information (presence / absence of mRNA, expression level, localization information).

  For example, the biological information generation unit 302 uses the signal detected by the excitation light detection unit 73 to display biological information (for example, mutant gene sequence information, SNPs information, expression gene information (presence / absence of mRNA, expression level, localization information)). Is generated, formatted into a predetermined file format, and processed into a form that can be transmitted and stored. For example, the biological information is preferably formed by shaping the expression gene name, expression level, attached image, and the like according to a method such as XML (extensible mark-up language).

  The input unit 79 acquires information on the medical condition (sickness name, change in appearance of the patient, blood test result, diagnostic result) (medical condition information) corresponding to the user's operation, and supplies the medical condition information to the network interface 77. To do.

  For example, the input unit 79 includes a keyboard, a mouse, an input book with a barcode (notebook book in which a barcode is associated with a disease name or symptom, and the disease name or symptom is captured by reading the barcode with a barcode scanner). The medical condition is input (obtained) from the outside using human hands. Of course, the input unit 79 may be any means that can input data from the outside. A medical condition (information) is a series of information related to a disease, such as a disease name, a change in appearance of a patient, a blood test result, and a diagnosis result.

  The network interface 77 transmits the board ID, biological information, and medical condition information to the server 15 via the Internet 14.

  The network interface 77 may be any one that can be connected to an external or internal server by wire or wireless, and has a connection function such as LAN (Local Area Network), wireless communication based on Bluetooth standards, or a mobile phone. Any one can be used. For example, the network interface 77 uses a TCP (Transmission Control Protocol) / IP (Internet Protocol) protocol, and connects to the server 15 which is an external server via the Internet 14 via the network 13 which is an example of a LAN.

  The communication unit 209 of the server 15 receives the substrate ID, the biological information, and the medical condition information transmitted from the bioassay device 12 and supplies them to the database management system 303.

  For example, the communication unit 209 can have the same configuration as the network interface 77.

  The database management system 303 records the biological information and the medical condition information in the biological information list 304 of the recording unit 208 in association with the board ID.

  For example, the database management system 303 acquires the board ID, the biological information, and the medical condition information transmitted from the bioassay device 12 received via the communication unit 209, and the biological information and the medical condition information are stored in the board ID. The biometric information is recorded in the biometric information list 304 so that the biometric information and the medical condition can be retrieved from the board ID. For example, the database management system 303 may use a commercial database software (Oracle (trademark) or the like) to link the board ID with the biological information and the medical condition information. You may make it manage in association.

  The biological information recorded in the biological information list 304 includes, for example, a gene name such as an ATM gene or a per gene, and a fluorescence intensity (for example, 4.0 or 1.6) corresponding to the expression level. , Including fluorescent image data.

  The recording unit 208 is composed of a recording medium such as an HDD (Hard Disk Drive), holds data in the medium to long term, can read at high speed, and can write analysis results. Of course, the recording unit 208 can also be configured by a tape, an optical disk, or the like.

  The analysis unit 305 analyzes the biological information and the disease state information recorded in the biological information list 304 and records the result in the analysis result list 306 of the recording unit 208.

  The analysis unit 305 calculates the correlation between the biological information registered in the recording unit 208, and associates the relationship with the medical condition.

  For example, as shown in FIG. 13, in the test result by the bioassay substrate 11-1 of the first person who develops hypertension and cancer A, the reaction of the well 37-1 (probe thereof) is large, and the well 37 -2 (probe) reaction is moderate and well 37-3 (probe) reaction is small.

  Here, a large reaction means that the detected fluorescence intensity is strong, a medium reaction means that the detected fluorescence intensity is medium, and a small reaction means that the detected fluorescence intensity is medium. This shows that the fluorescence intensity is weak.

  In addition, in the test result of the second person who has developed hypertension, the reaction of the well 37-1 (probe) is large and the reaction of the well 37-2 (probe) is moderate. The reaction of the well 37-3 (probe) is small.

  In the test result of bioassay substrate 11-3 of the third person who developed cancer B, the reaction of well 37-1 (probe) was small and the reaction of well 37-2 (probe) was moderate. The reaction of the well 37-3 (probe thereof) is large.

  In the test result by the bioassay substrate 11-4 of the fourth person who develops hypertension, the response of the well 37-1 (probe) is large, the reaction of the well 37-2 (probe) is moderate, Well 37-3 (probe) reaction is small.

  Similarly, in the test result of the bioassay substrate 11-5 of the fifth person who developed hypertension and cancer B, the reaction of the well 37-1 (probe) was moderate, and the probe of the well 37-2 (probe) ) Reaction is small, and the reaction of the well 37-3 (probe) is moderate.

  In the test result of bioassay substrate 11-6 of the sixth person who developed cancer A, the reaction of well 37-1 (probe) was small, the reaction of well 37-2 (probe) was large, and the well The reaction of 37-3 (probe) is small.

  In the test result of the seventh person who developed hypertension and cancer A, the reaction of the well 37-1 (probe) was large and the reaction of the well 37-2 (probe) was large. The reaction of the well 37-3 (probe) is small.

  The relationship between the reaction for each well 37 and the disease can be estimated from the data indicating the reaction for each well 37 and the data indicating the disease that has developed.

  For example, in the example shown in FIG. 13, a person who has a strong response to the well 37-1 (probe) tends to induce hypertension, and a person who has a strong response to the well 37-2 (probe) has cancer A and well 37. It is analyzed that a person with a strong -3 (probe) reaction tends to induce cancer B. When analyzing the correlation of a large number of biological information, there are cases where the pathological condition can be identified (of course, there is also a case where it cannot be detected significantly) in relation to the amount of expression in each part (each well). These identified related information is stored in the recording unit 208 as an analysis result.

  In this example, each site has been described as having a specific medical condition. However, in reality, multiple sites and multiple genes are related in a complex manner, and a large amount of expression necessarily induces a disease. However, it may be caused by a small expression level.

  Hereinafter, each well 37 is also simply referred to as a site.

  Next, biometric information recording processing by the bioassay device 12 that executes the test processing program and the server 15 that executes the server program will be described with reference to the flowchart of FIG.

  In step S <b> 1001, the user of the bioassay device 12 inserts the bioassay substrate 11 into the bioassay device 12. In step S1002, the user collects blood from the patient.

  In step S1003, the user extracts mRNA from the blood. In step S1004, the user amplifies (replicates) cDNA from the extracted mRNA by RT-PCR (Reverse Transcriptase (Reverse Transcription) Polymerase Chain Reaction). The user creates a sample solution S using the replicated cDNA as sample DNA. The user injects the sample solution S into the reservoir 93 of the bioassay device 12.

  In step S1005, the inspection processing program drops the cDNA on the bioassay substrate 11. That is, in step S1005, the test processing program causes the dropping unit 72 to drop the sample solution S containing cDNA into each well 37 of the bioassay substrate 11. The inspection processing program reacts the probe in each well 37 of the bioassay substrate 11 with the cDNA contained in the dropped sample solution S.

  In step S1006, the inspection processing program detects the fluorescence intensity of each well 37 of the bioassay substrate 11. In step S1007, the test processing program generates biological information from the array of probes on the bioassay substrate 11 (the type of probe arranged in each well 37) and the fluorescence intensity detected in the processing in step S1006. For example, in step S <b> 1007, the biological information generation unit 302 generates biological information from the type of probe arranged in each well 37 of the bioassay substrate 11 and the fluorescence intensity of each well 37 of the bioassay substrate 11.

  In step S1008, the inspection processing program reads the substrate ID from the bioassay substrate 11 that is mounted. For example, in step S1008, the test processing program causes the substrate ID reading unit 301 to read the substrate ID from the mounted bioassay substrate 11.

  In step S1009, the examination processing program acquires medical condition information. For example, in step S1009, the examination processing program acquires medical condition information based on a signal from the input unit 79 corresponding to the user's operation.

  In step S <b> 1010, the examination processing program transmits the board ID, biological information, and medical condition information to the server 15. For example, in step S1010, the examination processing program causes the network interface 77 to transmit the board ID, the biological information, and the medical condition information to the server 15 via the Internet 14.

  In step S2001, the server program receives the substrate ID, the biological information, and the medical condition information transmitted from the bioassay device 12. For example, in step S2001, the server program causes the communication unit 209 to receive the board ID, the biological information, and the medical condition information transmitted from the bioassay device 12, and acquires the board ID, the biological information, and the medical condition information. To do.

  In step S2002, the server program records the biological information and the medical condition information in association with the board ID.

  For example, in step S2002, the server program supplies the board ID, the biological information, and the medical condition information to the database management system 303, and causes the database management system 303 to record the biological information and the medical condition information in relation to the board ID. .

  For example, as illustrated in FIG. 15, the database management system 303 associates the biometric information list 304 recorded in the recording unit 208 with the substrate ID, such as observation information, medical condition information, and comments that are biometric information. Record.

  For example, in the biological information list 304 shown in FIG. 15, the fluorescence intensity obtained at the site 1 corresponding to the well 37-1 is 0.75 for the substrate ID “001023”, and the well 37-2 The fluorescence intensity obtained at the corresponding site 2 is 12.58, and the fluorescence intensity obtained at the site i corresponding to the i-th well 37-i is 0.07, which corresponds to the N-th well 37-N. Observation information which is an example of biological information indicating that the fluorescence intensity obtained at the site N is 1.92 is recorded.

  In the biometric information list 304 shown in FIG. 15, for a board ID “001023”, the disease name is “liver cancer”, the r-GTP is “29”, and the blood pressure is “120-76”. Certain medical condition information is recorded.

  Further, for example, in the biological information list 304 shown in FIG. 15, the fluorescence intensity obtained at the site 1 corresponding to the well 37-1 is 3.28 for the substrate ID “001024”, and the well 37− The fluorescence intensity obtained at the site 2 corresponding to 2 is 4.44, and the fluorescence intensity obtained at the site i corresponding to the i-th well 37-i is 9.42, so that the N-th well 37-N Observation information which is an example of biological information indicating that the fluorescence intensity obtained at the corresponding site N is 2.48 is recorded.

  In the biometric information list 304 shown in FIG. 15, for a board ID “001024”, the disease name is “liver cancer”, the r-GTP is “35”, and the blood pressure is “132-77”. Certain medical condition information is recorded.

  Further, for example, in the biological information list 304 shown in FIG. 15, the fluorescence intensity obtained at the site 1 corresponding to the well 37-1 is 1.11 for the substrate ID “158383”, and the well 37− The fluorescence intensity obtained at the site 2 corresponding to 2 is 0.59, and the fluorescence intensity obtained at the site i corresponding to the i-th well 37-i is 5.17, so that the N-th well 37-N Observation information which is an example of biological information indicating that the fluorescence intensity obtained at the corresponding site N is 8.33 is recorded.

  In the biometric information list 304 shown in FIG. 15, the disease name is “myocardial infarction”, the r-GTP is “33”, and the blood pressure is “126-80” for the board ID “158383”. Certain medical condition information is recorded.

  In the biometric information list 304 shown in FIG. 15, comments such as date, inspection purpose, and outline are recorded for the board ID.

  In step S2003, the server program performs correlation calculation between the biological information and the medical condition information to extract features. In step S2004, the server program stores the extracted features as analysis results, and the process ends.

  For example, in step S2003, the server program causes the analysis unit 305 to analyze the correlation between the observation information that is an example of the biological information recorded in the biological information list 304 and the disease state information, and the result is displayed in the analysis result list 306. Let me record.

  FIG. 16 is a diagram illustrating an example of the analysis result list 306. For example, in the analysis result list 306 shown in FIG. 16, in the biological information, when the fluorescence intensity obtained in the portion 74 corresponding to the 74th well 37-74 is 12.4 or more, the disease state 1 tends to be easily induced. It shows that. The analysis result list 306 shown in FIG. 16 indicates that in the biological information, when the fluorescence intensity obtained at the site 238 corresponding to the 238th well 37-238 is 2.1 or less, it tends to easily induce the disease state 2. Show.

  Further, for example, in the analysis result list 306 shown in FIG. 16, in the biological information, the fluorescence intensity obtained in the site 2 corresponding to the second well 37-2 is 7.4 or more, and the eleventh well 37-11 has The fluorescence intensity obtained at the corresponding part 11 is 8.8 or more, the predetermined fluorescence intensity is obtained at the other part, and the fluorescence intensity obtained at the part 118 corresponding to the 118th well 37-118 is 0.11 or less. In this case, it indicates that there is a tendency to easily induce disease state i.

  As described above, the analysis result list 306 records a relationship between a predetermined medical condition obtained as a result of analyzing the biological information list 304 and the biological information. That is, the analysis result list 306 records biometric information conditions that are likely to induce a predetermined medical condition.

  In addition, since a large number of corresponding biological information and medical condition information can be intensively recorded and analyzed, a significant analysis result showing the relationship between biological information and medical condition information more easily. You will be able to get

  Next, with reference to the flowchart of FIG. 17, an example of details of analysis processing of biological information and medical condition information corresponding to the processing of Step S2003 and Step S2004 will be described. In step S41, the analysis unit 305 acquires the fluorescence intensity for each part from the observation information that is an example of the biological information recorded in the biological information list 304, and classifies each part. For example, the analysis unit 305 determines whether each fluorescence intensity for each part is equal to or higher than a first threshold, and determines whether each fluorescence intensity for each part is equal to or higher than a second threshold. Each part is classified into one of the four classes by determining whether or not the fluorescence intensity for each part is equal to or greater than the third threshold value.

  Note that the classification method is not limited to the comparison between the fluorescence intensity and the threshold value. For example, the difference in fluorescence intensity between adjacent sites is compared with the threshold value, or the region around the region of interest is compared. A desired technique such as classification based on the distribution of fluorescence intensity can be used.

  In step S42, the analysis unit 305 searches for parts that are classified into the same class and have similar disease state information in each part. In step S43, the analysis unit 305 records the analysis result in the analysis result list 306.

  For example, in step S42, the analysis unit 305 determines that the i-th part is classified into the j-th class in the observation information, and there are m or more pieces of biological information having the same disease name in the medical condition information. , The fluorescence intensity for the j-th class of the i-th part and the disease state information indicating the disease of the disease name are recorded in the analysis result list 306.

  In step S44, the analysis unit 305 sets 2 as an initial value for the variable N.

  In step S45, the analysis unit 305 searches for arbitrary N sites that are classified into the same class and have similar disease state information. In step S <b> 46, the analysis unit 305 records the analysis result in the analysis result list 306.

  For example, when the variable N is 2, the analysis unit 305 classifies the i th part into the j th class, the p th part into the q th class in the observation information, and the same in the medical condition information. When there are m or more pieces of biological information in which disease names exist, it is assumed that the i-th region and p-th region are related to the disease of the disease name, and the fluorescence intensity and p for the j-th class of the i-th region The fluorescence intensity for the q th class of the th site and the disease state information indicating the disease of the disease name are recorded in the analysis result list 306.

  For example, when the variable N is r, the analysis unit 305 includes m or more pieces of biological information in which r predetermined portions are classified into a predetermined class in the observation information, and the same disease name exists in the disease state information. If it exists, it is assumed that there are relations between the r parts and the disease of the disease name, and the fluorescence intensity of each part and the disease state information indicating the disease of the disease name are recorded in the analysis result list 306.

  In step S47, the analysis unit 305 increments the variable N.

  In step S48, the analysis unit 305 determines whether or not the variable N is equal to or greater than a predetermined threshold. If it is determined that the variable N is not equal to or greater than the predetermined threshold, further analysis is performed. Returning to FIG.

  If it is determined in step S48 that the variable N is greater than or equal to a predetermined threshold value, the analysis ends and the process ends.

  Thus, for example, the relationship between the biological information and the medical condition information can be analyzed and the result can be recorded. As a result, it is possible to identify biological information that is highly likely to induce a predetermined disease.

  FIG. 18 is a block diagram illustrating functions of the data processing device 16 and the server 15 when the data processing device 16 registers the user ID and the board ID in the server 15 and the server 15 provides the biological information to the data processing device 16. FIG.

  Note that the blocks in FIG. 18 may be configured by software or may be configured by dedicated hardware.

  The data processing device 16 includes an encryption unit 351, a decryption unit 352, and a comparison unit 353.

  First, the data processing device 16 registers the board ID in the server 15. This board ID is a board ID that manages its own biological information, that is, a board ID transmitted to the server 15 together with the biological information.

  When registering a user ID and a board ID in the server 15, the input unit 256 acquires a user ID, a board ID, and a password for identifying the user in response to the operation of the user, and obtains the board ID and the password. Is supplied to the encryption unit 351 and the user ID is supplied to the communication unit 259. The encryption unit 351 encrypts the board ID based on the password supplied from the input unit 256 and supplies the encrypted board ID to the communication unit 259.

  Here, the user ID is an ID for identifying the user assigned to the user (patient) by operating the input unit 79 of the bioassay device 12. For example, the inspection system registers the user ID in the server 15 in advance, or the management organization issues the user ID.

  Further, the user can be a person such as a doctor who has examined the patient.

  The password is data that only the user knows.

  The password corresponds to a concealment code. Using this password, the encryption unit 351 (the concealment unit) executes the process of encrypting the board ID. As the encryption method, any common key encryption method may be used. For example, DES (Data Encryption Standard) is used, and the board ID is encrypted using the password as the encryption key.

  The encrypted board ID is registered in the server 15 via the Internet 14.

  That is, the communication unit 259 supplies the encrypted board ID supplied from the encryption unit 351 to the server 15 through the Internet 14 together with the user ID.

  On the other hand, the server 15 includes a database management system 354. The database management system 354 receives the user ID and the encrypted board ID list (when there are a plurality of board IDs) sent from the data processing device 16 and encrypts them in a list format to be described later. The substrate ID is recorded in the recording unit 208, the recorded substrate ID is read out as necessary, and the read out substrate ID is provided to the data processing device 16.

  It is preferable to use a communication method such as FTP (File Transfer Protocol) in processing such as registration or reading of the substrate ID.

  That is, the communication unit 209 of the server 15 receives the user ID transmitted from the data processing device 16 and the encrypted board ID, and supplies them to the database management system 354. The database management system 354 records the encrypted board ID in the board ID list 355 corresponding to the user ID.

  As described above, the data processing device 16 includes an input unit 256 that inputs a user ID and a concealment code (password), an encryption unit 351 that encrypts (conceals) the board ID with the concealment code, and a user ID. And a communication unit 259 that transmits the encrypted board ID to the other party.

  The concealment code may be any code that can be used for a technology for encrypting (encrypting) the substrate ID, such as a password or an encryption key. Further, the block for inputting the user ID and the block for inputting the concealment code may be the same or different. The method of inputting the user ID and concealment code is not limited to manual input using a keyboard or mouse, but the user ID and concealment code are stored in a storage medium such as a predetermined IC card (not shown). Reading may be performed via the data processing device 16 or a reading device connected to the data processing device 16, and any method may be used.

  The encryption unit 351 uses a concealment code as an encryption key, and encrypts using the encryption key (dedicated IC (Integrated Circuit) chip, IC card, PC (Personal Computer) board, etc.), or software. Can be realized. As an encryption algorithm in the encryption unit 351, encryption and decryption of a board ID, such as a common key encryption method such as DES (Data Encryption Standard) encryption and a public key encryption method such as RSA (Rivest-Shamir-Adelman) encryption, are performed. Any algorithm is possible.

  When the public key cryptosystem is used, the password for encryption and the password for decryption are different.

  When registering the user ID and the encrypted board ID, the communication unit 259 executes a predetermined protocol for establishing a connection with the server 15. For example, when registering the user ID and the encrypted board ID, the communication unit 259 performs a mutual authentication process with the server 15 before executing the registration process.

  Further, in the data processing device 16 according to the present invention, the communication unit 259 transmits the user ID together with the request for the board ID to the server 15 and receives the board ID transmitted from the server 15 to receive the board ID from the server 15. The board ID associated with the board ID is read by reading the board ID associated with the user ID, and further transmitting the board ID together with the request for biometric information to the server 15 and receiving the biometric information transmitted from the server 15. Information, if necessary, medical condition information is read out. Furthermore, in the data processing device 16 according to the present invention, the comparison unit 353 compares the analysis result analyzed by the server 15 from a large number of pieces of biological information with the biological information.

  The communication unit 259 can use a wired or wireless transmission medium and a desired protocol such as the TCP / IP protocol. For example, the communication unit 259 may use a communication technology used for WWW (World-Wide Web), and can appropriately use various information reading technologies and protocols.

  Further, the comparison unit 353 analyzes the correlation between the analysis result processed by the server 15 and the biological information read by the data processing device 16, thereby notifying the evaluation point and the medical condition according to the degree of relevance. It is a program that was made to do.

  The analysis result processed by the server 15 extracts a group (group) having a strong relationship from a lot of biological information and medical condition information collected from clients such as the bioassay device 12 and related information. This is data obtained by quantifying and quantifying etc.

  The data processing device 16 may be any device that can send and receive data and process data, such as general-purpose PCs, workstations, home servers, gateways, game machines, PDAs, and mobile phones. You may make it provide the function mentioned above in the apparatus 12. FIG. At this time, the bioassay device 12 may be the one used for the biological examination, or may be another bioassay device 12.

  Furthermore, a plurality of devices may be provided as the data processing device 16, and a registration process, a substrate ID acquisition process, and a biological information acquisition process may be performed individually.

  Next, in the server 15 according to the present invention, the board ID, the biological information, and the medical condition received from the client such as the bioassay device 12 are correlated and stored, and the stored biological information is analyzed and analyzed. An analysis unit 305 that generates a result; a database management system 354 that manages a list of user IDs and encrypted board IDs received from the client, searches for a board ID encrypted from the user ID, and returns a response; And a database management system 303 that searches and returns biometric information from the substrate ID.

  The database management system 354 or the database management system 303 may use commercial database software (Oracle (trademark) or the like) to link the board ID, the biological information, and the medical condition information, and constitutes the recording unit 208. You may make it manage in association with a hard disk by an original format.

  Further, the analysis unit 305 calculates a correlation between the biological information recorded in the server 15 and associates the relationship with the medical condition.

  The server 15 may be any server such as dedicated hardware, a board computer, a general-purpose high-speed computer, or a personal computer that has an appropriate processing speed and can manage data and process data. It doesn't have to be a machine.

  As described above, according to the present invention, gene mutation analysis, SNPs (single nucleotide polymorphism) analysis, gene expression frequency analysis, and the like are performed using the bioassay substrate 11 and the bioassay device 12, and the generated data is managed. Analyzes and systems that can make use of the analysis results for diagnosis and research are provided and can be used in drug discovery, clinical diagnosis, pharmacogenomics, forensic medicine and other related industries.

  Next, a method for performing diagnosis using registered biological information and analysis results will be described.

  First, a person (patient) to be diagnosed (or a doctor or a researcher may act on behalf) operates the input unit 256 to input a user ID and a password (confidential code). Next, the communication unit 259 reads the encrypted board ID list associated with the user ID from the server 15.

  In the example shown in FIG. 18, the communication unit 259 also serves as a list reading unit.

  The board ID list read from the server 15 is decrypted using the password previously input by the decryption unit 352. In practice, the password (confidential code) is used as an encryption key, and decryption processing is executed using DES or the like.

  Next, the data processing device 16 reads biometric information from the server 15 based on the board ID decoded by the decoding unit 352.

  Then, the data processing device 16 compares the analysis result of the server 15 read in advance with the read biological information by the comparison unit 353, detects a highly correlated part, and predicts a medical condition related thereto. To do. The process of predicting a medical condition is the same as the process described with reference to the flowchart of FIG.

  That is, when acquiring the board ID from the server 15, the input unit 256 acquires the medical condition information, the user ID for identifying the user, and the password in response to the operation of the user. The input unit 256 supplies the user ID to the communication unit 259 and also supplies the password to the decryption unit 352. Further, the input unit 256 supplies the medical condition information to the comparison unit 353.

  The communication unit 259 supplies the user ID supplied from the input unit 256 to the server 15 via the Internet 14.

  The communication unit 209 of the server 15 receives the user ID transmitted from the data processing device 16 and supplies it to the database management system 354. Based on the user ID supplied from the communication unit 209, the database management system 354 reads out the recorded board ID corresponding to the user ID from the board ID list 355. The read substrate ID is encrypted with a password. The database management system 354 supplies the read board ID to the communication unit 209.

  The communication unit 209 of the server 15 transmits the encrypted board ID to the data processing device 16 via the Internet 14. The communication unit 259 of the data processing device 16 receives the encrypted board ID transmitted from the server 15 and supplies the received board ID to the decryption unit 352. The decryption unit 352 decrypts the board ID encrypted with the password.

  Since only the data processing device 16 knows the password, other devices that do not know the password cannot obtain the board ID.

  The decryption unit 352 supplies the decrypted board ID to the communication unit 259. The communication unit 259 transmits the board ID to the server 15 via the Internet 14.

  The communication unit 209 of the server 15 receives a plain board ID transmitted from the data processing device 16 and supplies the received board ID to the database management system 303. The database management system 303 reads biometric information recorded corresponding to the board ID from the biometric information list 304 based on the board ID supplied from the communication unit 209. Further, the database management system 303 reads analysis results related to the read biological information from the analysis result list 306 based on the read biological information.

  The database management system 303 supplies the read biological information and the analysis result related to the biological information to the communication unit 209. The communication unit 209 transmits the biological information and the analysis result related to the biological information to the data processing device 16 via the Internet 14.

  The communication unit 259 of the data processing device 16 receives the biological information and the analysis result related to the biological information transmitted from the server 15, and sends the received biological information and the analysis result related to the biological information to the comparison unit 353. Supply.

  The comparison unit 353 compares the biological information and the analysis result related to the biological information with the disease state information, and causes the output unit 257 to display the comparison result.

  The data processing device 16 reads the encrypted board ID list from the server 15 using the user ID, adds a new board ID to be added to the list, and sends a new “encrypted board” to the server 15. The “ID list” may be re-registered.

  Alternatively, only the database management system 303 may be provided to execute the processing performed by the database management system 354. This is because these are executed as programs on the server and can be regarded as substantially the same.

  Furthermore, an encryption technique such as SSL (Secure Socket Layer) may be used so that data on a network such as the Internet cannot be illegally stolen by a third party.

  Next, the registration process of the user ID and the board ID by the data processing device 16 that executes the data processing program and the server 15 that executes the server program will be described with reference to the flowchart of FIG.

  In step S3101, the data processing program acquires a user ID by acquiring a signal from the input unit 256 corresponding to the user's operation. In step S3102, the data processing program acquires a substrate ID by acquiring a signal from the input unit 256 corresponding to a user operation.

  When the bioassay device 12 performs the registration process, the bioassay substrate 11 is attached to the bioassay device 12 so that the bioassay device 12 reads the substrate ID from the bioassay substrate 11. May be.

  In step S3103, the data processing program acquires a password by acquiring a signal from the input unit 256 corresponding to the user's operation. In step S3104, the data processing program encrypts the board ID with the password in the encryption unit 351.

  In step S <b> 3105, the data processing program causes the communication unit 259 to transmit the encrypted board ID and user ID to the server 15 via the Internet 14.

  In step S2101, the server program causes the communication unit 209 to receive the encrypted board ID and user ID transmitted from the data processing device 16. In step S2102, the server program causes the database management system 354 to search for a user ID from the board ID list 355.

  In step S2103, the server program determines whether the user ID is a new user ID based on the search result. If it is determined that the user ID is a new user ID, the received user ID is still in the board ID list 355. Since it is not recorded, the process proceeds to step S2104, the database management system 354 causes the user ID to be added to the board ID list 355, and the process proceeds to step S2105.

  If it is determined in step S2103 that the user ID is not a new user ID, the received user ID is already recorded in the board ID list 355, so the processing in step S2104 is skipped, and the procedure proceeds to step S2105.

  In step S2105, the server program causes the database management system 354 to record the encrypted board ID in the board ID list 355 in association with the user ID, and the process ends.

  As described above, since the board ID is encrypted and recorded, even if the user ID is known, it is not possible to obtain a flat board ID. Therefore, the server 15 cannot know the relationship between the user and the biological information and the medical condition information. Thereby, the privacy of the user, that is, the patient is protected.

  FIG. 20 is a diagram illustrating an example of the board ID list 355. In the board ID list 355 shown in FIG. 20, the user ID, the number of board IDs, and the board ID are arranged. The board ID list 355 stores encrypted board IDs corresponding to the number of board IDs corresponding to the user ID.

  For example, in the example of the board ID list 355 of FIG. 20, the number of board IDs “3” is recorded for the user ID “1111203”, and the board ID is “001023”. , And “013355”, which is an encrypted board ID or the like.

  In the example of the board ID list 355 of FIG. 20, the number of board IDs “1” is recorded for the user ID “1111204”, and the encrypted board ID is “053789”. Is recorded. Further, for example, in the example of the board ID list 355 of FIG. 20, the number of board IDs “5” is recorded and “109834” is encrypted for the user ID “1112000”. A board ID, an encrypted board ID “158380”, an encrypted board ID “211358”, and the like are recorded.

  In this way, the board ID list 355 stores the board IDs that are encrypted in correspondence with the user IDs. Since the board ID is encrypted, the server 15 cannot know the relationship between the board ID and the user. Therefore, the server 15 cannot know the relationship between the user and the biological information and the medical condition information.

  Even if a third party who does not know the password illegally obtains the user ID, the board ID, the biological information, and the medical condition information from the server 15, the third party cannot know the relationship between the biological information or the medical condition information and the user.

  Next, a process in which the data processing device 16 that executes the data processing program acquires biometric information and the like from the server 15 that executes the server program will be described with reference to the flowcharts of FIGS.

  In step S3201, the data processing program acquires a user ID by acquiring a signal from the input unit 256 corresponding to the user's operation. In step S <b> 3202, the data processing program causes the communication unit 259 to transmit a request for the board ID to the server 15 along with the user ID via the Internet 14.

  In step S2201, the server program causes the communication unit 209 to receive the user ID and board ID request transmitted from the data processing device 16. In step S2202, the server program causes the database management system 354 to read out the encrypted board ID recorded in correspondence with the user ID from the board ID list 355. In step S 2203, the server program causes the communication unit 209 to transmit the encrypted board ID to the data processing device 16 via the Internet 14.

  When a plurality of substrate IDs are recorded for one user ID, the server program transmits the plurality of substrate IDs recorded for the user ID to the data processing device 16.

  In step S3203, the data processing program causes the communication unit 259 to receive the encrypted board ID transmitted from the server 15.

  In step S3204, the data processing program acquires a password by acquiring a signal from the input unit 256 corresponding to the user's operation. In step S3205, the data processing program causes the decryption unit 352 to decrypt the board ID with the password. When a plurality of board IDs are received, the decrypting unit 352 decrypts each board ID with a password.

  In step S 3206, the data processing program causes the communication unit 259 to transmit a request for biometric information to the server 15 along with the board ID via the Internet 14.

  In step S2204, the server program causes the communication unit 209 to receive the board ID and the request for biometric information transmitted from the data processing device 16. In step S2205, the server program causes the database management system 303 to read the biometric information, the medical condition information, and the comments recorded in correspondence with the board ID from the biometric information list 304. In step S <b> 2206, the server program causes the communication unit 209 to transmit the read biological information, medical condition information, and comments to the data processing device 16 via the Internet 14.

  In step S3207, the data processing program causes the communication unit 259 to receive the biological information, the medical condition information, and the comments transmitted from the server 15. In step S3208, the data processing program causes the output unit 257 to display biometric information, medical condition information, and comments.

  In step S <b> 3209, the data processing program causes the communication unit 259 to transmit a request for the analysis result to the server 15 along with the board ID via the Internet 14.

  In step S2207, the server program causes the communication unit 209 to receive the board ID and the analysis result request transmitted from the data processing device 16. In step S2208, the server program causes the database management system 303 to read out from the analysis result list 306 the medical condition information related to the biological information recorded corresponding to the board ID, which is the analysis result. In step S <b> 2209, the server program causes the communication unit 209 to transmit the medical condition information as the analysis result to the data processing device 16 via the Internet 14.

  When the analysis result is requested without adding the substrate ID from the data processing device 16 (when only the analysis result request is transmitted), in step S2208, the server program executes the database management system. The medical condition information related to the biological information that is the analysis result may be read from 303 in the analysis result list 306. In this case, for example, in step S2208, the server program causes the database management system 303 to read all the medical condition information related to the biological information that is the analysis result from the analysis result list 306.

  In step S3210, the data processing program causes the communication unit 259 to receive the medical condition information that is the analysis result transmitted from the server 15. In step S3211, the data processing program causes the output unit 257 to display the medical condition information that is the analysis result.

  In step S3212, the data processing program causes the comparison unit 353 to compare the analysis result with the biological information, make a diagnosis, display the diagnosis result on the output unit 257, and the process ends.

  In this example, the board ID is transmitted together with the analysis result request. However, only the analysis result request is transmitted and all analysis results are received from the server, and the comparison unit 305 compares the biological information with the analysis result. Thus, diagnosis and disease state prediction may be performed.

  As described above, the user (patient) can acquire his / her biological information based on the password that only the user knows. In addition, the user can acquire analysis results related to his / her biological information.

  In this embodiment, the example in which the server ID is managed and stored in the server 15 has been described. However, this is managed by the user's PC or the like (whether or not the encryption is performed), The biometric information may be read from the server 15 by directly specifying the board ID.

  In addition, management of each individual's biological information itself may be performed by the user's PC or the like or the bioassay substrate 1 itself, and diagnosis may be performed using only analysis results obtained by analyzing a large number of biological information by the server 15. . However, in this case, since no contribution is made in generating the analysis result, some restriction may be provided for accessing the analysis result.

  In the present invention, a disk-shaped DNA disk using a magneto-optical disk has been described. However, the shape may be appropriately set (for example, a square, a rectangle, or an ellipse). In addition, although an example using a magneto-optical disk as a data recording layer was shown, magnetic recording tape with a predetermined recording function, semiconductor memory (EEPROM, FRAM, MRAM, etc.), printing technology, etc. are used as long as there is no problem. It shall be possible. Each means can be implemented by software or configured by hardware as much as possible. In addition, a protocol (FTP or the like) or a format (for example, a file format or a data storage format) or the like for communication is arbitrary within a realizable range.

  Thus, when the target substance is bound to the detection substance for detecting the target substance, the target substance can be detected. In addition, a detection substance that detects the target substance is placed on the substrate, a board ID that identifies itself is recorded, and the inspection device detects the binding between the detection substance and the target substance on the board, and the board ID is detected from the board. Reads out the status information related to the user's status corresponding to the user's operation, and sends the detection information, substrate ID, and status information indicating the detection result of the target substance to the information providing device via the network Control, the information processing device acquires the user ID that identifies the user, the board ID, and the encryption key for encrypting the board ID, encrypts the board ID based on the encryption key, and passes through the network. Control the transmission of the user ID and the encrypted board ID addressed to the information providing apparatus, and the information providing apparatus receives the detection information, the board ID, and the status information transmitted from the inspection apparatus, and the information. Processing equipment Controls the reception of user IDs and encrypted board IDs sent from the server, manages the recording of detection information and status information corresponding to the board IDs, and is encrypted corresponding to the user IDs. In the case of managing the recording of the substrate ID, the patient can read and record his / her own biological information while concentrating and recording the biological information so that the patient cannot be identified.

  In addition, it detects the binding between the detection substance and the target substance on the board, reads the board ID from the board, obtains status information about the user's state corresponding to the user's operation, and detects the target substance via the network When the transmission of the detection information, the board ID, and the status information indicating the result of the above to the other device is controlled, the information providing device records the biological information in a concentrated manner so that the patient cannot be identified. be able to.

  Obtain the user ID that identifies the user, the substrate ID that identifies the substrate on which the detection substance that detects the target substance is located, and the encryption key for encrypting the board ID, and then obtain the board ID based on the encryption key. Information providing device in the case of controlling the transmission of the user ID and the encrypted substrate ID addressed to another device that records and provides the results of the substrate inspection via the network In FIG. 4, the biological information is concentrated and recorded so that the patient cannot be identified, and the patient can read out the biological information of the patient.

  The binding of the detection substance and the target substance on the board sent from the inspection device that inspects the board on which the detection substance for detecting the target substance is arranged and the board ID for identifying itself is recorded Controls the reception of detection information indicating the result of detection, board ID, and status information related to the user status, and reception of user ID and encrypted board ID transmitted from other devices, and board ID If the record of detection information and status information corresponding to the user ID is managed, and the record of the encrypted board ID corresponding to the user ID is managed, the patient cannot be identified so that the patient cannot be identified. The patient can read out his / her biological information while concentrating and recording the information.

  The series of processes described above can be executed by hardware, but can also be executed by software. When a series of processing is executed by software, a program constituting the software may execute various functions by installing a computer incorporated in dedicated hardware or various programs. For example, it is installed from a recording medium in a general-purpose personal computer or the like.

  As shown in FIG. 6, FIG. 9, or FIG. 10, this recording medium is distributed to provide a program to a user separately from a computer, a magnetic disk 81 on which a program is recorded, a magnetic disk 231, Alternatively, a magnetic disk 281 (including a flexible disk), an optical disk 82, an optical disk 232, or an optical disk 282 (including a CD-ROM (Compact Disc-Read Only Memory) and a DVD (Digital Versatile Disc)), a magneto-optical disk 83, and a magneto-optical disk. The disk 233 or the magneto-optical disk 283 (including MD (Mini-Disc) (trademark)), or a package medium including the semiconductor memory 84, the semiconductor memory 234, the semiconductor memory 284, etc. Recorded program provided to user in pre-installed state ROM202 or ROM252 and are a hard disk included in the recording unit 208 or the recording unit 258.

  The program for executing the series of processes described above is installed in a computer via a wired or wireless communication medium such as a local area network, the Internet, or digital satellite broadcasting via an interface such as a router or a modem as necessary. You may be made to do.

  Further, in the present specification, the step of describing the program stored in the recording medium is not limited to the processing performed in chronological order according to the described order, but is not necessarily performed in chronological order. It also includes processes that are executed individually.

  In the present specification, the term “system” represents the entire apparatus constituted by a plurality of apparatuses.

1 is a block diagram illustrating a configuration of an embodiment of an inspection system according to the present invention. It is a figure which shows a bioassay board | substrate. It is a figure which shows a bioassay board | substrate. It is a figure explaining a bottom face. It is a figure explaining the probe DNA fixed to the bottom face. It is a block diagram explaining a bioassay apparatus. It is a figure explaining dripping of the solution containing sample DNA. It is a figure explaining a fluorescent labeling agent. It is a block diagram which shows the structure of a server. It is a block diagram which shows the structure of a data processor. It is a flowchart explaining the process of a test | inspection. It is a block diagram which shows the function of a bioassay apparatus and a server. It is a figure explaining the relationship between biometric information and medical condition information. It is a flowchart explaining the process of recording biometric information. It is a figure which shows the example of a biometric information list. It is a figure which shows the example of an analysis result list | wrist. It is a flowchart explaining the example of the detail of a process of analysis of biometric information and pathological information. It is a block diagram which shows the function of a data processor and a server. It is a flowchart explaining the registration process of user ID and board | substrate ID. It is a figure which shows the example of a board | substrate ID list. It is a flowchart explaining the process of acquisition of biometric information and the like. It is a flowchart explaining the process of acquisition of biometric information and the like.

Explanation of symbols

  DESCRIPTION OF SYMBOLS 1 Test | inspection system, 11 Bioassay board | substrate, 12 Bioassay apparatus, 13 Network, 14 Internet, 15 Server, 16 Data processing apparatus, 72 Dripping part, 73 Excitation light detection part, 74 Control / servo part, 75 Recording / reproducing part, 76 Control unit, 77 network interface, 79 input unit, 81 magnetic disk, 82 optical disk, 83 magneto-optical disk, 84 semiconductor memory, 201 CPU, 202 ROM, 203 RAM, 208 storage unit, 231 magnetic disk, 232 optical disk, 233 magneto-optical Disk, 234 semiconductor memory, 251 CPU, 252 ROM, 253 RAM, 258 storage unit, 281 magnetic disk, 282 optical disk, 283 magneto-optical disk, 284 semiconductor memory, 301 Board ID Reading Unit, 302 Biometric Information Generation Unit, 303 Database Management System, 304 Biometric Information List, 305 Analysis Unit, 306 Analysis Result List, 351 Encryption Unit, 352 Decryption Unit, 353 Comparison Unit, 354 Database Management System, 355 Board ID list

Claims (22)

A substrate for inspecting a target substance, an inspection apparatus for inspecting the target substance using the substrate, an information providing apparatus for recording and providing a result of the inspection, and a process based on the result of the inspection provided from the information providing apparatus An inspection system comprising an information processing device to be executed,
The substrate is
A detection substance for detecting the target substance is arranged,
The board ID that identifies itself is recorded,
The inspection device includes:
Detection means for detecting binding between the detection substance and the target substance on the substrate;
Read means for reading the substrate ID from the substrate;
Obtaining means for obtaining state information relating to the user's state corresponding to the user's operation;
Detection information indicating the detection result of the target substance addressed to the information providing apparatus via a network, the substrate ID, and first communication control means for controlling transmission of the state information, and
The information processing apparatus includes:
An acquisition unit for acquiring a user ID for identifying a user, the board ID, and an encryption key for encrypting the board ID;
Encryption means for encrypting the substrate ID based on the encryption key;
And second communication control means for controlling transmission of the user ID and the encrypted board ID addressed to the information providing apparatus via the network,
The information providing apparatus includes:
Reception of the detection information, the board ID, and the state information transmitted from the inspection apparatus, and reception of the user ID and the encrypted board ID transmitted from the information processing apparatus. Third communication control means for controlling;
First record management means for managing the record of the detection information and the state information corresponding to the substrate ID;
And a second record management means for managing the encrypted record of the board ID corresponding to the user ID. The second record management means of the information providing apparatus is an encryption that is recorded corresponding to the user ID when a request for the substrate ID is transmitted together with the user ID from the information processing apparatus. Controlling the reading of the substrate ID,
The third communication control means of the information providing apparatus controls transmission of the encrypted board ID addressed to the information processing apparatus via the network;
The second communication control means of the information processing apparatus controls reception of the encrypted board ID transmitted from the information providing apparatus;
The information processing apparatus includes:
The inspection system according to claim 1, further comprising decryption means for decrypting the encrypted board ID with the encryption key. The first record management means of the information providing apparatus is recorded corresponding to the board ID when the detection information request is transmitted together with the board ID from the information processing apparatus. Controls reading of detection information,
The third communication control means of the information providing device controls transmission of the detection information addressed to the information processing device via the network;
The inspection system according to claim 2, wherein the second communication control unit of the information processing apparatus controls reception of the detection information transmitted from the information providing apparatus. In the inspection apparatus for inspecting the target substance from the substrate on which the detection substance for detecting the target substance is arranged and the board ID for identifying itself is recorded,
Detection means for detecting binding between the detection substance and the target substance on the substrate;
Read means for reading the substrate ID from the substrate;
Obtaining means for obtaining state information relating to the user's state corresponding to the user's operation;
An inspection apparatus comprising: transmission control means for controlling transmission of detection information indicating the result of detection of the target substance, the substrate ID, and the state information to another apparatus via a network. In the inspection method of the inspection apparatus for inspecting the target substance from the substrate on which the detection substance for inspecting the target substance is arranged and the board ID for identifying itself is recorded
A detection step of detecting binding between the detection substance and the target substance on the substrate;
A reading step of reading the substrate ID from the substrate;
An obtaining step for obtaining state information relating to a user's state corresponding to the user's operation;
And a transmission control step for controlling transmission of detection information indicating the result of detection of the target substance, the substrate ID, and the state information to another apparatus via a network. A program that causes a computer that controls an inspection apparatus that inspects the target substance from a substrate on which a detection substance for inspecting the target substance is arranged and a substrate ID that identifies itself is recorded, to execute an inspection process,
A detection step of detecting binding between the detection substance and the target substance on the substrate;
A reading step of reading the substrate ID from the substrate;
An obtaining step for obtaining state information relating to a user's state corresponding to the user's operation;
And a transmission control step for controlling transmission of the detection information indicating the detection result of the target substance, the substrate ID, and the state information to another apparatus via a network. Medium on which various programs are recorded. In a program for causing a computer that controls an inspection apparatus that inspects the target substance from a board on which a detection substance for inspecting the target substance is arranged and a board ID for identifying itself is recorded, to perform an inspection process,
A detection step of detecting binding between the detection substance and the target substance on the substrate;
A reading step of reading the substrate ID from the substrate;
An obtaining step for obtaining state information relating to a user's state corresponding to the user's operation;
A transmission control step for controlling transmission of detection information indicating the detection result of the target substance, the substrate ID, and the state information to another apparatus via a network. A user ID for specifying a user, a substrate ID for specifying a substrate on which a detection substance for detecting a target substance is arranged, and an acquisition means for acquiring an encryption key for encrypting the board ID;
Encryption means for encrypting the substrate ID based on the encryption key;
Communication control means for controlling transmission of the user ID and the encrypted board ID to another apparatus that records and provides the result of the board inspection via the network. Information processing device. The communication control means further includes
Sending the request for the board ID together with the user ID to the other device via the network,
Control communication to receive the encrypted board ID transmitted from the other device;
The information processing apparatus according to claim 8, further comprising decryption means for decrypting the received encrypted board ID with the encryption key. The communication control means further includes
Sending a request for detection information indicating the detection result of the target substance together with the substrate ID to the other device via the network,
The information processing apparatus according to claim 9, wherein communication is controlled so as to receive the detection information transmitted from the other apparatus. In an information processing method of an information processing apparatus for processing information,
An acquisition step of acquiring a user ID for specifying a user, a substrate ID for specifying a substrate on which a detection substance for detecting a target substance is arranged, and an encryption key for encrypting the substrate ID;
An encryption step for encrypting the substrate ID based on the encryption key;
A communication control step for controlling transmission of the user ID and the encrypted board ID to another apparatus that records and provides the result of the inspection of the board via a network. Information processing method. A program that causes a computer that controls an information processing device to execute information processing,
An acquisition step of acquiring a user ID for specifying a user, a substrate ID for specifying a substrate on which a detection substance for detecting a target substance is arranged, and an encryption key for encrypting the substrate ID;
An encryption step for encrypting the substrate ID based on the encryption key;
A communication control step for controlling transmission of the user ID and the encrypted board ID to another apparatus that records and provides the result of the inspection of the board via a network. A recording medium on which a computer-readable program is recorded. In a program that causes a computer that controls an information processing device to perform information processing,
An acquisition step of acquiring a user ID for specifying a user, a substrate ID for specifying a substrate on which a detection substance for detecting a target substance is arranged, and an encryption key for encrypting the substrate ID;
An encryption step for encrypting the substrate ID based on the encryption key;
A communication control step for controlling transmission of the user ID and the encrypted board ID to another apparatus that records and provides the result of the inspection of the board via a network. program. The detection substance and the target substance on the board, which are transmitted from an inspection apparatus that inspects a board on which a detection target for detecting a target substance is arranged and a board ID for identifying itself is recorded Detection information indicating the result of detection of the connection with the board, reception of the board ID and status information on the user status, and reception of the user ID and the encrypted board ID transmitted from another device Communication control means for controlling
First record management means for managing the record of the detection information and the state information corresponding to the substrate ID;
An information providing apparatus comprising: a second record management unit that manages the record of the encrypted board ID corresponding to the user ID. The second record management means is encrypted corresponding to the user ID when the request for the substrate ID is transmitted together with the user ID from the other device. Control the reading of the board ID,
The information providing apparatus according to claim 14, wherein the communication control unit controls transmission of the encrypted board ID addressed to the other apparatus via the network. When the detection information request is transmitted together with the substrate ID from the other device, the first record management unit reads the detection information recorded corresponding to the substrate ID. Control
The information providing apparatus according to claim 15, wherein the communication control unit controls transmission of the detection information addressed to the other apparatus via the network. The information providing apparatus according to claim 14, further comprising an analysis unit that analyzes a relationship between the detection information and the state information that are recorded. The first record management means controls reading of the analysis result related to the detection information when the request for the analysis result is transmitted from the other device,
The information providing apparatus according to claim 17, wherein the communication control unit controls transmission of the analysis result addressed to the other apparatus via the network. When the analysis result request is transmitted together with the substrate ID from the other device, the first record management means relates to the detection information recorded corresponding to the substrate ID. The information providing apparatus according to claim 18, wherein reading of the analysis result is controlled. In the information providing method of the information providing apparatus that provides information,
The detection substance and the target substance on the board, which are transmitted from an inspection apparatus that inspects a board on which a detection target for detecting a target substance is arranged and a board ID for identifying itself is recorded Detection information indicating the result of detection of the connection with the board, reception of the board ID and status information on the user status, and reception of the user ID and the encrypted board ID transmitted from another device A communication control step for controlling
A first record management step for managing records of the detection information and the state information corresponding to the substrate ID;
And a second record management step for managing the record of the encrypted board ID corresponding to the user ID. A program for causing a computer that controls the information providing apparatus to execute a providing process,
The detection substance and the target substance on the board, which are transmitted from an inspection apparatus that inspects the board on which the detection substance for detecting the target substance is arranged and the board ID for identifying itself is recorded Detection information indicating the result of detection of the connection with the board, reception of the board ID and status information on the user status, and reception of the user ID and the encrypted board ID transmitted from another device A communication control step for controlling
A first record management step for managing records of the detection information and the state information corresponding to the substrate ID;
A recording medium on which a computer-readable program is recorded, comprising: a second recording management step for managing the recording of the encrypted board ID corresponding to the user ID. In a program for causing a computer that controls an information providing apparatus to perform a providing process,
The detection substance and the target substance on the board, which are transmitted from an inspection apparatus that inspects the board on which the detection substance for detecting the target substance is arranged and the board ID for identifying itself is recorded Detection information indicating the result of detection of the combination with the board, reception of the board ID and status information regarding the user status, and reception of the user ID and the encrypted board ID transmitted from another device A communication control step for controlling
A first record management step for managing records of the detection information and the state information corresponding to the substrate ID;
And a second record management step for managing the record of the encrypted board ID corresponding to the user ID.

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