JP2005081081A - Doppler ultrasonograph and diagnostic parameter measurement method - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To show a measurement region on a trace waveform when a diagnostic parameter, such as PI (pulsatility index) or RI (resistance index), is automatically measured on the trace waveform generated from a doppler spectrum. <P>SOLUTION: A spectrum data generating section 7 generates doppler spectrum data using ultrasonic receipt signals obtained from a specific part of a subject to be examined, and a trace waveform generating section 9 generates the trace waveform showing, for example, temporal change in the maximum frequency component of the doppler spectrum data. Further, a parameter measurement section 11 measures the diagnostic parameter, such as PI or RI, in the specific region of the trace waveform set by a PS/ED (peak of systolic/end of diastolic) detecting section 10. On the other hand, a display section 15 highlights or scrolls back the region on the trace form, where the latest values on the trace waveform are measured, when the trace waveform is displayed still to check the diagnostic parameter. <P>COPYRIGHT: (C)2005,JPO&NCIPI

Description

  The present invention relates to an ultrasonic Doppler diagnostic apparatus and a diagnostic parameter measurement method for measuring blood flow velocity information and tissue movement information in a living body by utilizing an ultrasonic Doppler effect.

  The ultrasonic diagnostic apparatus radiates an ultrasonic pulse generated from a piezoelectric vibrator built in an ultrasonic probe into a subject, and generates an ultrasonic reflected wave generated by a difference in acoustic impedance of the subject tissue by the piezoelectric vibrator. It is received and displayed on the monitor. This diagnostic method is widely used for functional diagnosis and morphological diagnosis of various organs of a living body because a real-time two-dimensional image can be easily observed with a simple operation by simply bringing an ultrasonic probe into contact with the body surface. Ultrasound diagnostic methods for obtaining biological information from reflected waves from tissues or blood cells in a living body have made rapid progress with the development of two major technologies, the ultrasonic pulse reflection method and the ultrasonic Doppler method. The obtained B-mode image and color Doppler image are indispensable in today's ultrasonic image diagnosis.

  On the other hand, there is a Doppler spectrum method as a method for quantitatively and accurately obtaining a blood flow velocity at an arbitrary position of a subject. In this Doppler spectrum method, ultrasonic transmission / reception is performed a plurality of times on the same part of the subject at regular intervals, and the ultrasonic reflected wave reflected by a moving reflector such as a blood cell is used for ultrasonic transmission / reception. Quadrature detection is performed using a reference signal having a frequency substantially equal to the resonance frequency of the piezoelectric vibrator to detect a Doppler signal. Then, a Doppler signal at a desired part is extracted from the Doppler signal by a range gate, and Doppler spectrum data is generated by performing FFT analysis on the extracted Doppler signal.

  According to such a procedure, Doppler spectrum data is continuously generated for Doppler signals obtained from a desired part of the subject, and a plurality of generated Doppler spectrum data are sequentially arranged, so-called Doppler spectrum image data is obtained. Generate. In general, in order to accurately set the range gate at a desired observation site in the subject, the range gate is set under B-mode image observation, and the position of the range gate is displayed on the B-mode image. .

  The Doppler spectrum data obtained by this ultrasonic Doppler diagnostic device is generally generated with frequency (f) on the vertical axis, time (t) on the horizontal axis, and the power (intensity) of each frequency component as luminance (gradation). Based on the Doppler spectrum data, various diagnostic parameters are measured.

  That is, in this measurement method, first, for each Doppler spectrum data obtained continuously in time, the maximum flow velocity Vp corresponding to the maximum frequency fp of the Doppler frequency component distributed in the frequency axis direction, or the average The position of the average flow velocity Vc corresponding to the frequency fc is set, and a trace waveform indicating the time change of the position of the maximum flow velocity Vp and the average flow velocity Vc is generated. Next, in this trace waveform, a waveform peak PS (Peak of Systolic) occurring in the systole and a waveform peak ED (End of Diastolic) occurring in the diastole are detected for each of the heartbeat intervals. Based on the position information of the PS or ED, the HR (Heart Rate) of the blood flow in the blood vessel is measured. Further, from the trace waveform in the heart beat section set by the PS or ED, the peripheral blood vessel is measured. Measures diagnostic parameters such as PI (Pulsatility Index) and RI (Resistance Index).

The above-described generation of trace waveforms of Vp and Vc, detection of PS / ED, and measurement of diagnostic parameters such as PI and RI have been based on manual operation for a frozen Doppler spectrum image. In recent years, automatic tracing of Vp and Vc and automatic measurement of HR, PI, or RI for a Doppler spectrum image displayed in real time has become possible (see, for example, Patent Document 1).
US Pat. No. 5,628,321 (pages 7-9, FIGS. 5-8)

  However, in the method described in Patent Document 1, based on the position information of PS and ED detected in the automatically generated trace waveform of Vp or Vc, the measured value of the diagnostic parameter automatically measured is displayed on the monitor. At this time, the operator could not easily associate the heart beat section in which the diagnostic parameter was measured with the heart beat section in the trace waveforms for a plurality of heart beats displayed on the same monitor.

  That is, since it was not possible to grasp whether or not the values of various diagnostic parameters obtained by automatic measurement are based on an accurately generated trace waveform or an accurately set PS or ED, the obtained diagnosis There was a problem with the reliability of the measured values of the parameters.

  The present invention has been made in view of such conventional problems, and its purpose is to perform measurement when automatically measuring diagnostic parameters such as PI and RI from Vp or Vc trace waveforms in Doppler spectrum image data. An object of the present invention is to provide an ultrasonic Doppler diagnostic apparatus and a diagnostic parameter measurement method capable of clearly indicating a section or measurement timing in the trace waveform.

  In order to solve the above-described problem, the ultrasonic Doppler diagnostic apparatus according to the first aspect of the present invention sets a desired range gate position for a reception signal obtained by performing ultrasonic transmission / reception on a subject. A Doppler signal detecting means for detecting a Doppler signal, a spectrum data generating means for generating a plurality of spectrum data in time series for the Doppler signal, and a desired feature amount in each of the plurality of spectrum data. Trace waveform data generating means for detecting and generating temporal changes in the feature amount as trace waveform data, trace waveform displaying means for displaying the trace waveform data, and setting a plurality of heartbeat intervals for the trace waveform data Section setting means for performing diagnostic parameter measurement for measuring a diagnostic parameter in a predetermined heart beat section of the plurality of heart beat sections And diagnostic parameter display means for displaying the value of the measured diagnostic parameter, wherein the trace waveform display means highlights the trace waveform data of the predetermined heartbeat interval in which the diagnostic parameter is measured. It is said.

  On the other hand, the diagnostic parameter measurement method of the present invention according to claim 12 detects a Doppler signal by setting a desired range gate position with respect to a reception signal obtained by performing ultrasonic transmission / reception on a subject. A step of generating spectrum data for the Doppler signal, a step of detecting a desired feature amount in the spectrum data, and generating a temporal change of the feature amount as trace waveform data, and the trace waveform Setting a plurality of heartbeat intervals for the data, measuring diagnostic parameters in a predetermined heartbeat interval of the plurality of heartbeat intervals, and highlighting the trace waveform data in the predetermined heartbeat interval. It is characterized by.

  According to a thirteenth aspect of the present invention, there is provided a diagnostic parameter measurement method for detecting a Doppler signal by setting a desired range gate position with respect to a reception signal obtained by performing ultrasonic transmission / reception on a subject. A step of generating spectrum data for the Doppler signal, a step of detecting a desired feature amount in the spectrum data, and generating a temporal change of the feature amount as trace waveform data, and the trace waveform A step of setting a plurality of heartbeat intervals for the data; a step of measuring diagnostic parameters in a predetermined heartbeat interval of the plurality of heartbeat intervals; and a freeze display of the latest measurement results of the trace waveform data and the diagnostic parameters. In addition, the trace waveform data in the predetermined heartbeat interval where the latest measurement result is measured It is characterized by the step of displaying gradation.

  According to the present invention, when measuring various diagnostic parameters from the trace waveform obtained based on the Doppler spectrum data, the measurement section of the diagnostic parameter is highlighted in the trace waveform. It becomes easy to grasp the relationship with the trace waveform in the measurement section, and the reliability of the measurement result is improved.

  Based on the trace waveform of the maximum flow velocity Vp automatically set in the Doppler spectrum image data, diagnostic parameters such as HR, PI, and RI are automatically measured, and the measurement section at this time is statically displayed on the monitor. This is clearly shown in the trace waveform.

(Device configuration)
Hereinafter, the configuration of the ultrasonic Doppler diagnostic apparatus and the operation of each unit in the embodiment of the present invention will be described with reference to FIGS. FIG. 1 is a block diagram showing the overall configuration of the ultrasonic Doppler diagnostic apparatus according to the present embodiment, and FIG. 2 shows a block diagram of a transmission / reception unit and a data generation unit constituting the ultrasonic Doppler diagnostic apparatus.

  An ultrasonic Doppler diagnostic apparatus 100 shown in FIG. 1 includes an ultrasonic probe 20 that transmits / receives ultrasonic waves to / from a subject, a transmission / reception unit 40 that transmits / receives electrical signals to / from the ultrasonic probe 20, and a transmission / reception unit. 40, a data generation unit 50 that performs signal processing to obtain B-mode image data, color Doppler image data, and further Doppler spectrum data from the received signal obtained from 40, and the data generation unit 50 continuously in the time direction. A blood flow evaluation for generating a trace waveform of the maximum blood flow velocity Vp or the average blood flow velocity Vc based on a plurality of obtained Doppler spectrum data, and measuring various diagnostic parameters related to hemodynamic diagnosis based on the trace waveform. Unit 30 and each data obtained in the data generation unit 50 or a trace wave obtained in the blood flow evaluation unit 30 And a data storage unit 8 for storing the like and various diagnostic parameter measurement results.

  Furthermore, the ultrasonic Doppler diagnostic apparatus 100 generates a reference signal for generating, for example, a continuous wave or a rectangular wave having a frequency substantially equal to the center frequency (fo) of the ultrasonic pulse to the transmission / reception unit 40 or the data generation unit 50. Unit 1, display unit 15 that displays image data and Doppler spectrum data generated by data generation unit 50, and further, a trace waveform generated by blood flow evaluation unit 30, measurement values of diagnostic parameters, and the like, and an operator Input information 16 for inputting patient information, image display mode, ultrasound data collection conditions, and various command signals, an ECG unit 60 for separately collecting an electrocardiogram waveform of the subject, and the above-described ultrasound Doppler diagnosis A system control unit 17 that controls each unit of the apparatus 100 is provided.

  The ultrasonic probe 20 is for transmitting and receiving ultrasonic waves by bringing its front surface into contact with the surface of a subject, and a plurality of (N) minute piezoelectric vibrators arranged in a one-dimensional manner at its tip. Have in the department. This piezoelectric transducer is an electroacoustic transducer that converts electrical pulses into ultrasound pulses (transmitted ultrasound) during transmission, and converts reflected ultrasound waves (received ultrasound) into electrical signals (received signals) during reception. It has a function to do. The center frequency (fo) of the ultrasonic pulse that greatly affects the resolution and sensitivity of the ultrasonic image is substantially determined by the thickness of the piezoelectric vibrator. The ultrasonic probe 20 is configured to be small and light, and is connected to the transmission unit 2 and the reception unit 3 of the transmission / reception unit 40 via a cable. The ultrasonic probe 20 has a sector scan support, a linear scan support, a convex scan support, and the like, and is arbitrarily selected according to the diagnosis part. In the following, for the purpose of blood vessel diagnosis of the carotid artery or the like, the case where the ultrasonic probe 20 corresponding to the sector scan is used will be described. However, the present invention is not limited to this method, and may be linear scan correspondence or convex scan correspondence. .

  Next, the transmission / reception unit 40 illustrated in FIG. 2 receives the transmission unit 2 that generates a drive signal for radiating the transmission ultrasonic wave from the ultrasonic probe 20 and the reception ultrasonic wave from the ultrasonic probe 20. Part 3 is provided.

  The transmission unit 2 includes a rate pulse generator 41, a transmission delay circuit 42, and a pulsar 43. The rate pulse generator 41 determines a repetition period (Tr) of transmission ultrasonic waves radiated into the subject. The rate pulse is generated by dividing the continuous wave or the rectangular wave supplied from the reference signal generator 1, and this rate pulse is supplied to the transmission delay circuit 42.

  The transmission delay circuit 42 is composed of the same number (N channels) of independent delay circuits as the piezoelectric vibrators used for transmission, and transmits ultrasonic waves to a predetermined depth in order to obtain a narrow beam width in transmission. A delay time for converging and a delay time for radiating transmission ultrasonic waves in a predetermined direction are given to the rate pulse, and this rate pulse is supplied to the pulser 43. On the other hand, the pulser 43 has the same number (N channels) of independent drive circuits as the piezoelectric vibrators used for transmission, and drives the drive pulses for driving the piezoelectric vibrators built in the ultrasonic probe 20 at the rate. Generate based on pulse.

  The receiving unit 3 includes a preamplifier 44, a reception delay circuit 45, and an adder 46. The preamplifier 44 amplifies a minute signal converted into an electric signal (reception signal) by the piezoelectric vibrator to ensure sufficient S / N. The reception delay circuit 45 sets a delay time for converging the reception ultrasonic wave from a predetermined depth in order to obtain a narrow reception beam width and a strong reception directivity with respect to the reception ultrasonic wave from the predetermined direction. The delay time is given to the output of the preamplifier 44, and then the output of the reception delay circuit 45 given the predetermined delay time is sent to the adder 46 for addition synthesis.

  Next, the data generation unit 50 includes a B-mode data generation unit 4 for generating B-mode image data for the reception signal output from the adder 46 of the reception unit 3, and quadrature detection for the reception signal. And a Doppler signal detector 5 for detecting a Doppler signal, a color Doppler data generator 6 for generating color Doppler image data based on the detected Doppler signal, and a spectrum for measuring the frequency spectrum of the Doppler signal. A data generation unit 7 is provided.

  The B-mode data generation unit 4 includes a logarithmic converter 51, an envelope detector 52, and an A / D converter 53. The input signal of the B-mode data generation unit 4, that is, the reception signal output from the adder 46 of the reception unit 3 is logarithmically converted in the logarithmic converter 51 and the weak signal is relatively emphasized. Next, the envelope detector 52 performs envelope detection on the logarithmically converted reception signal, removes ultrasonic frequency components, and detects only amplitude information. The A / D converter 53 converts the output signal of the envelope detector 52 into a digital signal and generates B-mode image data.

  On the other hand, the Doppler signal detection unit 5 of FIG. 2 includes a π / 2 phase shifter 54, mixers 55-1 and 55-2, and LPFs (low-pass filters) 56-1 and 56-2, which will be described later. In operation, quadrature detection is performed on the received signal supplied from the receiving unit 3 of the transmitting / receiving unit 40 to detect a Doppler signal.

  Next, the color Doppler data generation unit 6 includes an A / D converter 57 including two channels, a Doppler signal storage circuit 58, an MTI filter 59, and an autocorrelation calculator 60. The A / D converter 57 converts the Doppler signals output from the LPFs 56-1 and 56-2 of the Doppler signal detection unit 5, that is, the analog signals subjected to quadrature detection, into digital signals, and a Doppler signal storage unit. Save to 58. Next, the MTI filter 59, which is a high-pass digital filter, reads the Doppler signal once stored in the Doppler signal storage unit 58, and uses this Doppler signal for respiratory movement or pulsatile movement of the organ. The resulting Doppler component (clutter component) is removed. Further, the autocorrelation calculator 60 calculates an autocorrelation value for the Doppler signal from which only the blood flow information is extracted by the MTI filter 59, and further, based on the autocorrelation value, an average blood flow velocity value and variance Calculate the value.

  On the other hand, the spectrum data generation unit 7 includes an SH (sample hold circuit) 61, an HPF (high pass filter) 62, an A / D converter 63, and an FFT (Fast-Fourier-Transform) analyzer 64. Yes. Then, FFT analysis is performed on the Doppler signal obtained in the Doppler signal detection unit 5. The SH 61, HPF 62, and A / D converter 63 are all composed of two channels, and each channel has a complex component of the Doppler signal output from the Doppler signal detector 5, that is, an actual component (I component). And an imaginary component (Q component) are supplied.

  Next, basic operations of the Doppler signal detection unit 5 and the spectrum data generation unit 7 which are important components in generating the Doppler spectrum data of the present invention will be described in more detail with reference to the time chart of FIG.

  3A is a reference signal output from the reference signal generator 1, FIG. 3B is a rate pulse of a period Tr output from the rate pulse generator 41 of the transceiver 40, and FIG. 3 (c) indicates a received signal obtained from the adder 46 of the receiving unit 3.

  3D shows the quadrature detection output output from the LPF 56 of the Doppler signal detector 5, and FIG. 3E determines the sampling (range gate) position of the SH 61 in the color Doppler data generator 6. 3 (f) shows the Doppler signal sampled and held by the SH 61, and FIG. 3 (g) shows the Doppler signal in the range gate smoothed by the HPF 62. Show.

  That is, the received signal (FIG. 3C) output from the receiving unit 3 in FIG. 2 is input to the first input terminals of the mixers 55-1 and 55-2 of the Doppler signal detecting unit 5. On the other hand, the reference signal (FIG. 3A) of the reference signal generator 1 having a repetition frequency fo substantially equal to the center frequency of the received signal is directly supplied to the second input terminal of the mixer 55-1, and π The reference signal whose phase is shifted by 90 degrees in the / 2 phase shifter 54 is sent to the second input terminal of the mixer 55-2. The multiplication outputs from the mixers 55-1 and 55-2 are sent to the LPFs 56-1 and 56-2, and the frequency of the input signal of the Doppler signal detector 5 and the reference signal supplied from the reference signal generator 1 are repeated. The sum component with the frequency (fo) (component near 2fo) is removed, and only the difference component (component near zero frequency) is extracted as a Doppler signal ((d) in FIG. 3).

  Next, the SH 61 has a sampling pulse (range gate pulse) generated by dividing the Doppler signal output from the LPFs 56-1 and 56-2 and the reference signal of the reference signal generator 1 by the system controller 17. Is supplied ((e) in FIG. 3), and the Doppler signal from a desired distance is sampled and held by this sampling pulse ((f) in FIG. 3). This sampling pulse is generated after the delay time Ts from the rate pulse ((b) of FIG. 3) that determines the timing at which the transmission ultrasonic wave is emitted, and this delay time Ts can be arbitrarily set in the input unit 16. is there.

  That is, the operator can extract the Doppler signal at the desired distance Lg from the ultrasonic probe 20 by changing the delay time Ts of the sampling pulse. At this time, the delay time Ts and the desired distance Lg have a relationship of 2Lg / C = Ts, where C is the sound speed of the subject.

  Next, the stepped noise component superimposed on the Doppler signal of the desired distance Lg output from the SH 61 is removed by the HPF 62 ((g) in FIG. 3), and the smoothed Doppler signal is converted to A / After being converted into a digital signal by the D converter 63, it is supplied to the FFT analyzer 64 to generate frequency spectrum data (Doppler spectrum data).

  The FFT analyzer 64 includes an arithmetic circuit and a storage circuit (not shown). The Doppler signal output from the A / D converter 63 is temporarily stored in the storage circuit, and the arithmetic circuit is a series of Doppler stored in the storage circuit. FFT analysis is performed in a predetermined section of the signal.

  FIG. 4 shows an FFT analysis method in the FFT analyzer 64. FIG. 4A shows the Doppler signal Ax input to the FFT analyzer 64, and FIG. 4B shows the Doppler signal Ax. The Doppler spectrum data Bx (x = 1, 2,...) Obtained by FFT analysis of a predetermined section is shown. Of the discrete Doppler signals (FIG. 4A) output from the A / D converter 63 of the spectrum data generator 7, for example, FFT analysis is performed on m Doppler signal components q1 to qm. The first Doppler spectrum data B1 for the spectrum components p1 to pm is generated. Next, m Doppler signal components q1 + j to qm + j after time ΔT are FFT-analyzed to generate new Doppler spectrum data B2. FIG. 4A shows the case where j = 3.

  Similarly, FFT analysis is sequentially performed on m Doppler signal components of q1 + 2j to qm + 2j after time 2ΔT, q1 + 3j to qm + 3j... After time 3ΔT, and the Doppler spectrum for spectrum components p1 to pm. Data B3, B4,... Are generated. (FIG. 4B).

  Next, returning to FIG. 1, the blood flow evaluation unit 30 includes a trace waveform generation unit 9, a PS / ED detection unit 10, and a parameter measurement unit 11. Then, the trace waveform generator 9 generates the maximum frequency fp (that is, the maximum flow velocity Vp) for each of a plurality of Doppler spectrum data (B1, B2, B3...) Obtained at the ΔT interval in the spectrum data generator 7. And the average frequency fc (that is, the average flow velocity Vc) is calculated, and further, a trace waveform indicating the maximum blood flow velocity Vp corresponding to the maximum frequency fp or the temporal change of the average blood flow velocity Vc corresponding to the average frequency fc is generated. .

但し、Ｓ（ｆｓ）はＦＦＴ分析器６４によって得られる周波数ｆｓにおけるスペクトラムパワーを示す。 FIG. 5 shows a method for calculating the above-described maximum frequency fp and average frequency fc, and the maximum frequency fp is obtained based on the intersection of a preset frequency spectrum threshold value S0 and Doppler spectrum data Bx. On the other hand, the average frequency fc can be calculated by the following equation (1), for example.

Here, S (fs) indicates the spectrum power at the frequency fs obtained by the FFT analyzer 64.

  In the following description, for the sake of simplicity, the maximum blood flow rate Vp corresponding to the maximum frequency fp of the Doppler spectrum data is the maximum flow rate Vp of Doppler spectrum data, and similarly, the average blood corresponding to the average frequency fc. The flow velocity Vc is referred to as the average flow velocity Vc of Doppler spectrum data.

  Next, the PS / ED detection unit 10 of the blood flow evaluation unit 30 indicates the systolic phase of the heart with respect to the trace waveform of the maximum flow velocity Vp or the average flow velocity Vc generated by the trace waveform generation unit 9. Set the position of Peak of Systolic and ED (End of Diastolic) indicating the expansion period. The PS / ED detector 10 sets the same heartbeat interval based on the electrocardiogram waveform supplied from the separately provided ECG unit 60 when it is difficult to set the PS or ED in the trace waveform. It is.

  Then, the parameter measurement unit 11 is a hemodynamic diagnosis parameter set in the PS / ED detection unit 10 based on the trace waveform of the maximum flow velocity Vp or the average flow velocity Vc, for example, in the heartbeat interval of the ED-ED interval. A certain heart rate (HR: Heat Rate), PI (Palusatility Index), and RI (Resistance Index) are measured.

  FIG. 6 shows the relationship between the Doppler spectrum data and the trace waveform. The Doppler spectrum data Bx at time t = T0 is shown at the left end, and the maximum flow velocity Vp and the average measured from the Doppler spectrum data BX are shown. Trace waveforms Cp and Cc indicating temporal changes in the flow velocity Vc are shown in association with the Doppler spectrum data Bx. PSS and ED are set in the trace waveform Cp of the maximum flow velocity Vp. When this PS and ED are automatically set, for example, one PS during one heartbeat is obtained by a first-order differential calculation or a second-order differential calculation for detecting an inflection point performed after smoothing the trace waveform Cp. A plurality of ED candidate points are detected, and one ED candidate point within a predetermined range with respect to the PS is selected from these ED candidate points and set as an ED.

但し、図６に示すように、ｈ１及びｈ２は、ＥＤ−ＥＤ区間におけるトレース波形Ｃｐの最大値（maximal systolic frequency）及び最小値（maximal end-diastolic frequency）であり、ｈ０は、前記区間におけるトレース波形の平均値（time averaged frequency）である。 From the ED thus obtained, an ED-ED interval is set as a heartbeat interval, and the above-described diagnostic parameter is measured and displayed in this ED-ED interval. That is, HR can be obtained by first measuring the time of the ED-ED interval and calculating the heart rate per minute from this measurement result. On the other hand, PI or RI is usually calculated based on the following equation (2).

However, as shown in FIG. 6, h1 and h2 are the maximum value (maximal systolic frequency) and the minimum value (maximal end-diastolic frequency) of the trace waveform Cp in the ED-ED section, and h0 is the trace in the section. It is the average value (time averaged frequency) of the waveform.

  Next, the data storage unit 8 shown in FIG. 1 stores B-mode image data, color Doppler image data generated by the data generation unit 50, and spectrum data. Further, the trace waveform data generated in the blood flow evaluation unit 30 based on the spectrum data, the PS (or ED) position (time) information set on the trace waveform, and the ED-ED cycle of the trace waveform data Measurement values such as the diagnostic parameters HR, PI, and RI measured in step 1 are also stored.

  On the other hand, the display unit 15 includes a display data memory (not shown), a conversion circuit, and a monitor, and B-mode image data, color Doppler image data, Doppler spectrum data, trace waveform data of Vp or Vc, Measurement results such as diagnostic parameters HR, PI and RI are synthesized according to a predetermined format in the display data memory, and then subjected to D / A conversion and television format conversion in a conversion circuit, and then to a monitor such as a CRT or a liquid crystal display. Is displayed.

  FIG. 7 shows a specific example of a display method on the monitor of the display unit 15. On this monitor, for example, an image data display area 200 in which B-mode image data and color Doppler image data are combined and displayed, and a trace waveform display area 300 in which trace waveform data is displayed superimposed on Doppler spectrum data. And a measured value display area 400 in which measured values of diagnostic parameters such as PI and RI are displayed as a list.

  In the B-mode image and color Doppler image displayed in the image data display area 200, a Doppler marker 201 indicating the detection direction of the Doppler signal and a Doppler signal detection set in the crossing area of the Doppler marker 201 and the blood vessel image 202 are displayed. Range gate position 203 is displayed.

  On the other hand, for example, a PS marker (×) and an ED marker (+) are superimposed and displayed on the trace waveform Cp of the maximum flow velocity Vp in the trace waveform display area 300. The trace waveform Cp and the trace waveform Cc of the average flow velocity Vc described above can be displayed in real time and static (hereinafter referred to as freeze display). In the freeze display, the trace waveform highlight display or the scroll back display is automatically performed in the section (ED-ED section) in which the diagnostic parameter is finally measured. According to such a display method, the final measured value of the diagnostic parameter displayed in the measured value display area 400 can be associated with the section on the trace waveform where the final measurement is performed.

  Further, the Doppler spectrum data and the trace waveform data that are freeze-displayed in the trace waveform display area 300 can be arbitrarily scrolled in the time direction by an input device such as a trackball provided in the input unit 16. Note that the above-described highlight display or scroll back display is a feature of the present embodiment, and details thereof will be described in the description of the diagnostic parameter measurement procedure described later.

  Next, the input unit 16 includes an input device such as a display panel, a keyboard, a trackball, a mouse, and a selection button on the operation panel, and setting of patient information, an image display mode, an ultrasonic data collection condition, a display condition, and the like. Various command signals are input. In particular, the above input devices are used to set the range gate position for Doppler signal acquisition, to select real-time display and freeze display for trace waveform display, to select highlight display and scroll back display for freeze display, and to manually scroll trace waveforms. Performed by the operator used.

  The system control unit 17 includes a CPU and a storage circuit (not shown), and sets patient information, image display mode, ultrasonic data collection conditions, display conditions, range gate position, and the like input in advance from the input unit 16 by the operator. Selection information relating to values and display methods is stored in the storage circuit. On the other hand, the CPU performs overall control of each unit of the ultrasonic Doppler diagnostic apparatus 100 and control of the entire system based on the information input from the input unit 16.

  The ECG unit 60 is provided for collecting the electrocardiographic waveform of the subject, and the electrocardiographic waveform obtained by the ECG unit 60 is supplied to the PS / ED detector 10 of the blood flow evaluation unit 30. When it is difficult to set the PS or ED of the trace waveform by the PS / ED detector 10, the heart rate interval is set based on the electrocardiogram waveform obtained from the ECG unit 60.

(Measurement procedure for diagnostic parameters)
Next, the diagnostic parameter measurement procedure in this embodiment will be described with reference to FIGS. FIG. 8 is a flowchart showing the diagnostic parameter measurement procedure in this embodiment.

  Prior to the collection of ultrasound data, the operator sets patient information, image display mode, ultrasound data collection conditions, display conditions, a spectrum threshold value S0 for obtaining the maximum flow velocity Vp, and the like at the input unit 16, The setting information is sent to and stored in a storage circuit (not shown) of the system control unit 17. In this embodiment, display of B-mode image data, color Doppler image data, and Doppler spectrum data is selected as the image display mode, and further, as shown in FIG. 2, ultrasonic transmission / reception directions for collecting Doppler signals ( θD) and range gate position (Lg) are initially set (step S1 in FIG. 8).

  When these initial settings are completed, the operator fixes the tip (ultrasonic wave transmission / reception surface) of the ultrasonic probe 20 to a predetermined position on the surface of the subject body, and the first ultrasonic wave transmission / reception direction (θ1 direction). In contrast, ultrasonic transmission / reception for obtaining B-mode data and color Doppler data is performed. That is, the rate pulse generator 41 of FIG. 2 divides the reference signal supplied from the reference signal generator 1 to generate a rate pulse that determines the repetition period Tr of the ultrasonic pulse radiated into the subject. And the rate pulse is supplied to the transmission delay circuit 42.

  Next, the transmission delay circuit 42 uses, as a rate pulse, a focusing delay time for focusing the ultrasonic wave to a predetermined depth and a deflection delay time for transmitting the ultrasonic wave in the first scanning direction (θ1). The rate pulse is supplied to the pulser 43. Then, the pulser 43 supplies a drive signal generated by driving the rate pulse to the N piezoelectric vibrators in the ultrasonic probe 20 via a cable, so that the pulse signal is super-extended with respect to the first scanning direction of the subject. A sound pulse is emitted.

  A part of the ultrasonic pulse radiated to the subject is reflected at an interface or tissue between organs having different acoustic impedances. Further, when this ultrasonic wave is reflected by a moving reflector such as a heart wall or blood cell, the ultrasonic frequency is subjected to Doppler shift.

  The reflected ultrasonic wave (received ultrasonic wave) reflected by the tissue or blood cell of the subject is received by the piezoelectric vibrator of the ultrasonic probe 20 and converted into an electric signal (received signal). 3 is amplified by an N-channel independent preamplifier 44 and sent to an N-channel reception delay circuit 45.

  The reception delay circuit 45 receives the convergence delay time for converging the ultrasonic waves from a predetermined depth and the deflection delay time for receiving with a strong reception directivity in the first scanning direction. After giving the signal, it is sent to the adder 46. The adder 46 adds and synthesizes the N-channel reception signals output from the reception delay circuit 45, combines them into one reception signal, and supplies the reception signal to the B-mode data generation unit 4.

  The output signal of the adder 46 supplied to the B-mode data generation unit 4 is subjected to logarithmic conversion, envelope detection, and A / D conversion, and then stored in the B-mode image data storage area in the data storage unit 8 of FIG. Is done.

  On the other hand, in the generation of color Doppler image data, ultrasonic transmission / reception is continuously performed a plurality of times (L times) in the first scanning direction by the same procedure as described above to obtain the Doppler shift of the received signal. The frequency analysis is performed on the received signal obtained at this time.

  That is, the reception signal obtained by performing the first ultrasonic transmission / reception for color Doppler in the first scanning direction by the transmission / reception unit 40 is supplied from the adder 46 to the Doppler signal detection unit 5, and the mixer 55- 1, 55-2 and LPFs 56-1, 56-2 are subjected to quadrature phase detection and converted into a two-channel complex signal. Each of the real component and the imaginary component of the complex signal is converted into a digital signal by the A / D converter 57 of the color Doppler data generation unit 6 and then stored in the Doppler signal storage unit 58. Similar processing is performed on the received signals obtained by the second to Lth ultrasonic transmission / reception in the first scanning direction to collect complex signals and store them in the Doppler signal storage circuit 225.

  When the storage of the complex signal obtained by L ultrasonic transmission / reception in the first scanning direction in the Doppler signal storage unit 58 is completed, the system control unit 17 stores the complex signal stored in the Doppler signal storage unit 58. Complex signal components corresponding to a predetermined position (depth) are sequentially read out from the signal and supplied to the MTI filter 59. The MTI filter 59 performs a filtering process on the supplied complex signal component, eliminates a tissue Doppler component (clutter component) caused by a motion of a tissue such as a myocardium, and the blood flow caused by the blood flow. Extract only Doppler components.

  The autocorrelation calculator 60 that has received the complex signal from which the blood flow Doppler component has been extracted performs autocorrelation processing using the complex signal, and further, based on the autocorrelation processing result, the average velocity value of the blood flow And variance value or power value are calculated. Such calculation is also performed on other positions (depths) in the ultrasonic wave transmission / reception direction, and the calculated average velocity value, variance value, power value, etc. of the blood flow in the first scanning direction are shown. 1 is stored in the color Doppler image data storage area in the data storage unit 8.

  Next, the system control unit 17 performs the same ultrasonic wave transmission / reception in the second scanning direction (θ2) to the Mth scanning direction (θM). The B-mode image data and color Doppler image data obtained at this time are stored in the B-mode image data area and the color Doppler image data area in the data storage unit 8.

  On the other hand, an ultrasonic wave transmission / reception for collecting Doppler spectrum data is initialized, alternately with the B-mode or color Doppler ultrasonic wave transmission / reception for the first to Mth scanning directions. For the direction (θD), for example, it is sequentially performed with a period of 2Tr. Also in this case, ultrasonic transmission / reception is performed in the θD direction by the same procedure as the color Doppler ultrasonic transmission / reception, and the output signal (reception signal) of the adder 46 is supplied to the Doppler signal detection unit 5.

  Then, as already described in FIG. 3, the Doppler signal detection unit 5 supplies a complex signal obtained by performing quadrature detection on the received signal to the SH 61 of the spectrum data generation unit 7 (step of FIG. 8). S2). On the other hand, a sampling pulse corresponding to the initially set range gate position Lg is supplied from the system controller 17 to the SH 61, and the complex signal is sampled and held based on the sampling pulse. Then, the output of SH 61 obtained by ultrasonic transmission / reception performed a plurality of times in the cycle Tr with respect to the scanning direction θD is smoothed by the HPF 62, then converted into a digital signal by the A / D converter 63, and FFT is performed. The data is stored in a storage circuit (not shown) of the analyzer 64.

  The arithmetic circuit (not shown) of the FFT analyzer 64 sets a plurality of sections shifted by a predetermined time (ΔT) with respect to continuously collected Doppler signals, as described in FIG. FFT analysis is performed on the Doppler signal to generate Doppler spectrum data (step S3 in FIG. 8).

  That is, as shown in FIG. 4A, the arithmetic circuit of the FFT analyzer 64 has, for example, m pieces of q1 to qm with respect to discrete Doppler signals obtained with a period twice the rate pulse period Tr. The signal components are read out and subjected to FFT analysis to calculate Doppler spectrum data B1 composed of spectrum components p1 to pm. Then, the calculated Doppler spectrum data B1 is supplied to and stored in the data storage unit 8 and is also supplied to the trace waveform generation unit 9 of the blood flow evaluation unit 30, and the maximum frequency fp ( The maximum flow velocity Vp) and the average frequency fc (average flow velocity Vc) are calculated. The maximum flow velocity Vp and the average flow velocity Vc are stored in the data storage unit 8 (step S4 in FIG. 8).

  Similarly, the FFT analyzer 64 of the spectrum data generation unit 7 performs Doppler spectrum data for m Doppler signal components after time ΔT, time 2ΔT, time 3ΔT, and so on shown in FIG. B2, B3, B4... Are calculated, and the trace waveform generation unit 9 of the blood flow evaluation unit 30 calculates the maximum flow velocity Vp and the average flow velocity Vc for these Doppler spectrum data. The calculated Doppler spectrum data B2, B3, B4... And the maximum flow velocity Vp or the average flow velocity Vc are stored in the data storage unit 8.

  Accordingly, in the Doppler spectrum data storage area of the data storage unit 8, Doppler spectrum image data showing temporal changes of Doppler spectrum data as two-dimensional data, and the maximum flow velocity Vp or average flow velocity calculated for the Doppler spectrum data. Trace waveform data Cp and Cc indicating temporal changes in Vc are sequentially stored (step S5 in FIG. 8).

  Next, the PS / ED detection unit 10 of the blood flow evaluation unit 30 reads, for example, the trace waveform data Cp from the data storage unit 8, and sets PS and ED for the trace waveform data Cp. Then, the set position information of PS and ED is stored in the data storage unit 8 and supplied to the parameter measurement unit 11 together with the trace waveform data Cp (step S6 in FIG. 8).

  On the other hand, the parameter measurement unit 11 calculates HR from the length of the ED interval (ED-ED interval) successively set in the trace waveform Cp, and the maximum value h1 and minimum obtained in the trace waveform at the ED-ED interval. By substituting the value h2 and the average value h0 into the equation (2), PI and RI are sequentially measured, and these measurement results are stored in the data storage unit 8 (step S7 in FIG. 8).

  Therefore, in the data storage unit 8, in addition to the B-mode image data, color Doppler image data, and Doppler spectrum image data generated in real time, the trace waveform data corresponding to the Doppler spectrum image data and the position of the PS / ED are stored. Information and further measurement results of diagnostic parameters are stored for a predetermined period.

  By the procedure described above, the above-described data stored in the data storage unit 8 are combined and displayed on the display unit 15. That is, the B-mode image data stored in the B-mode image data storage area of the data storage unit 8 and the color Doppler image data stored in the color Doppler image data storage area are combined, and the monitor shown in FIG. It is displayed in the image display area 200. The Doppler spectrum image data is displayed in the trace waveform display area 300 by superimposing the trace waveform data and a marker indicating the position of PS / ED. Further, the latest measurement values such as the diagnostic parameters HR and PI, and RI are displayed in the measurement value display area 400.

  That is, the system control unit 17 reads out each data in the data storage unit 8 at a predetermined time interval, supplies it to the display data memory of the display unit 15, and synthesizes it according to a predetermined display format. Then, these data are supplied to the conversion circuit, and D / A conversion and TV format conversion are performed and displayed on the monitor (step S6 in FIG. 8).

  Next, a freeze display method in the trace waveform display unit 15 once stored in the data storage unit 8 will be described with reference to FIGS. However, in these figures, only the trace waveform Cp of the maximum flow velocity Vp is shown for the sake of simplicity, but in the actual case, as shown in the trace waveform display area 300 of FIG. 7, the Doppler spectrum image Ds. It is preferable to display the trace waveform Cp or the trace waveform Cc in a superimposed manner.

  FIG. 9A shows a real-time display method of a trace waveform using the moving bar MB. For example, old trace waveform data is a new trace waveform at the position of the moving bar MB that moves at a predetermined speed from the left end to the right end. Updated to data. For example, as the moving bar MB moves, the trace waveform Cp of the maximum flow velocity Vp measured in real time, the PS marker, and the ED marker are displayed in the order of PS1, ED1, PS2, ED2, and PS3. Then, the moving bar MB that has reached the right end at the time of PS3 returns to the left end, and the trace waveform, PS marker, and ED marker that are already displayed while moving toward the right end are newly updated after PS3. The trace waveform to be measured is updated to the PS marker and ED marker.

  On the other hand, the parameter measurement unit 11 of the blood flow evaluation unit 30 displays HR, PI, or RI in one heartbeat interval determined by the interval between ED2 and ED1 when the latest ED2 is displayed in the trace waveform Cp. Measure diagnostic parameters such as Then, the old measured value already stored in the data storage unit 8, that is, the value of the diagnostic parameter measured in the section between ED1 and ED0 (not shown) is updated to the new measured value, and the updated HR, PI Alternatively, RI or the like is newly displayed in the measured value display area 400 of the diagnostic parameter shown in FIG.

  In this way, when a new ED is obtained as the moving bar MB moves, the parameter measurement unit 11 performs the latest measurement of the diagnostic parameter in the ED-ED section that is one heartbeat section away from the ED, and performs the diagnosis. The old measurement value already displayed in the parameter measurement value display area 400 is updated to the latest measurement value.

  Next, FIG. 9B shows a first display method when the trace waveform displayed in real time is stopped (frozen) and observed, and this display method displays the measured value of the diagnostic parameter. The trace waveform of the ED-ED section in which the latest measured value of the diagnostic parameter displayed in the region 400 is measured is displayed with high luminance (highlight display).

  At the time of freeze display of the trace waveform, the operator inputs a freeze display command from the input unit 16 at a desired timing while observing the trace waveform displayed in real time (step S8 in FIG. 8), and further, a highlight display command. Are input from the same input unit 16 (step S9 in FIG. 8). Upon receiving these command signals, the system control unit 17 supplies a control signal to the display data memory of the display unit 15 and sets the number of heartbeat intervals that can be displayed simultaneously on the monitor of the display unit 15 with reference to the MB position. Trace waveform data (for example, trace waveforms from PS1 to MB in FIG. 9B) is read from the data storage unit 8 and stored in the trace waveform data storage area of the display data memory of the display unit 15.

  Next, the magnitude of the luminance signal in the trace waveform data in the ED1-ED2 section (that is, the section in which the latest measurement of the diagnostic parameter was performed) one heartbeat section from the latest ED ED2 in the obtained trace waveform data is obtained. change.

  By displaying the trace waveform data generated by the above-described procedure on the monitor via the conversion circuit of the display unit 15, as shown in FIG. 8B, the ED-ED section in which the latest measurement of the diagnostic parameter is performed. The trace waveform is highlighted (step S10 in FIG. 8).

  Next, FIG. 10 (a) shows a trace waveform real-time display method using the moving bar MB as in FIG. 9 (a), and a description thereof will be omitted. On the other hand, FIG. 10 (b) shows a second display method in the case of observing the trace waveform displayed in real time while being frozen (freeze), and this display method measured the latest diagnostic parameters. A display (scrollback display) is automatically performed so that the ED-ED section is positioned at the right end of the trace waveform display region 300.

  In this case, the operator inputs a freeze display command from the input unit 16 at a desired timing while observing the trace waveform displayed in real time (step S7 in FIG. 8), and further, the scroll back display command is input to the same input unit. 16 (step S8 in FIG. 8). Upon receiving these command signals, the system control unit 17 supplies control signals to the display data memory of the display unit 15 and simultaneously displays them on the monitor of the display unit 15 based on the position where the latest ED is set. Trace waveform data of a plurality of possible heart rate intervals is read from the data storage unit 8 and stored in the trace waveform data storage area of the display data memory of the display unit 15.

  By displaying the trace waveform data generated by the above-described procedure on the monitor via the conversion circuit of the display unit 15, as shown in FIG. 10B, the ED-ED section in which the latest measurement of the diagnostic parameter is performed. Is always displayed at the right end of the trace waveform display area 300 (step S10 in FIG. 8).

  As described above, according to the present embodiment, when the trace waveform is stopped and the detailed observation is performed, the section in which the latest diagnostic parameter is measured can be easily recognized by highlight display or scroll back display. The reliability in parameter measurement can be easily grasped from the trace waveform, and the diagnostic efficiency can be improved.

  As mentioned above, although the Example of this invention has been described, this invention is not limited to said Example, It can change and implement. For example, in the present embodiment, HR, PI, and RI have been described as examples of diagnostic parameters, but other diagnostic parameters may be used. In the measurement of these diagnostic parameters, the trace waveform Cp of the maximum flow velocity Vp of the Doppler spectrum is mainly used, but the trace waveform Cc of the average flow velocity Vc or another trace waveform may be used.

  On the other hand, PS and ED displayed in the trace waveform are not limited to the above-described markers, and can be identified using characters and symbols, for example. Furthermore, in the trace waveform display area 300, the case where the trace waveform data is superimposed on the Doppler spectrum image has been described, but only the trace waveform data is displayed or the trace waveform data and the Doppler spectrum image data are displayed separately. There may be.

  Furthermore, although the setting of the heartbeat interval in the above-described embodiment is performed at the ED-ED interval, other setting methods such as a PS-PS interval may be used.

  In addition, as shown in FIG. 1, a biological signal measuring device such as an electrocardiograph or an electroencephalograph is separately provided, and when it is difficult to measure a heartbeat interval in the PS / ED detector 10, the biological signal measuring device A heartbeat interval may be set from a biological signal supplied by the user, and a diagnostic parameter may be measured, or a trace waveform may be highlighted or scrolled back based on the set interval.

  Furthermore, the above-described highlight display and scroll back display are not limited to freeze display of trace waveform data, and may be performed in real time display.

1 is a block diagram showing the overall configuration of an ultrasonic Doppler diagnostic apparatus according to an embodiment of the present invention. The block diagram which shows the structure of the transmission / reception part and data processing part in the Example. The time chart which shows the basic operation | movement of the Doppler signal detection part in the Example, and a spectrum data generation part. The figure which shows the FFT analysis method of the Example. The figure which shows the calculation method of the maximum frequency component and average frequency component of a Doppler spectrum in the Example. The figure which shows the relationship between the Doppler spectrum data and trace waveform in the Example. The figure which shows the specific example of the display method in the display part of the Example. The flowchart which shows the measurement procedure of the diagnostic parameter in the Example.

The figure which shows the real-time display method and 1st freeze display method of a trace waveform.
The figure which shows the real-time display method and 1st freeze display method of the trace waveform in the Example. The figure which shows the real-time display method and 2nd freeze display method of the trace waveform in the Example.

Explanation of symbols

DESCRIPTION OF SYMBOLS 1 ... Reference signal generation part 2 ... Transmission part 3 ... Reception part 4 ... B-mode data generation part 5 ... Doppler signal detection part 6 ... Color Doppler data generation part 7 ... Spectrum data generation part 8 ... Data storage part 9 ... Trace waveform generation Unit 10 PS / ED detector 11 Parameter measurement unit 15 Display unit 16 Input unit 20 Ultrasonic probe 30 Blood flow evaluation unit 40 Transmission / reception unit 50 Data generation unit 60 ECG unit 100 Ultrasonic Doppler Diagnostic equipment

Claims (13)

Doppler signal detection means for detecting a Doppler signal by setting a desired range gate position with respect to a reception signal obtained by performing ultrasonic transmission / reception on a subject;
Spectrum data generating means for generating a plurality of spectrum data in time series for the Doppler signal,
Trace waveform data generating means for detecting a desired feature amount in each of the plurality of spectrum data and generating a temporal change of the feature amount as trace waveform data;
Trace waveform display means for displaying the trace waveform data;
Section setting means for setting a plurality of heartbeat sections for the trace waveform data;
Diagnostic parameter measuring means for measuring a diagnostic parameter in a predetermined heart beat section of the plurality of heart beat sections;
Diagnostic parameter display means for displaying the value of the measured diagnostic parameter;
The ultrasonic Doppler diagnostic apparatus characterized in that the trace waveform display means highlights the trace waveform data of the predetermined heartbeat interval in which the diagnostic parameter is measured.   2. The ultrasonic Doppler diagnostic apparatus according to claim 1, wherein the trace waveform data generating unit generates trace waveform data of at least one of a maximum frequency and an average frequency in the spectrum data.   The ultrasonic wave according to claim 1, wherein the trace waveform display means highlights the trace waveform data in the predetermined heartbeat interval in which the value of the diagnostic parameter displayed by the diagnostic parameter display means is measured. Doppler diagnostic device.   The trace waveform data includes a freeze display selection unit, and the trace waveform display unit includes the trace waveform data freeze-displayed by the freeze display selection unit. 4. The ultrasonic Doppler diagnostic apparatus according to claim 3, wherein the trace waveform data is highlighted.   5. The highlighting performed by the trace waveform display means is a highlight display of the trace waveform data in the predetermined heartbeat interval in which the value of the diagnostic parameter is measured. Ultrasonic Doppler diagnostic device.   The ultrasonic wave according to claim 3 or 4, wherein the highlighting performed by the trace waveform display means is a scrollback display of the trace waveform in the heartbeat interval in which the value of the diagnostic parameter is measured. Doppler diagnostic device.   The ultrasonic diagnostic apparatus according to claim 1, wherein the section setting means sets the heartbeat section based on at least one of PS (Peak of Systolic) and ED (End of Diastolic).   The ultrasonic diagnostic apparatus according to claim 1, wherein the section setting unit sets the heartbeat section based on an electrocardiographic waveform collected from the subject by an ECG measurement unit.   The diagnostic parameter measuring means measures at least one of HR (Heart Rate), PI (Pulsatility Index), and RI (Resistance Index) based on the trace waveform data in the predetermined heartbeat interval. The ultrasonic Doppler diagnostic apparatus according to claim 1.   2. The ultrasonic Doppler diagnostic apparatus according to claim 1, wherein the trace waveform data and the measured value of the diagnostic parameter are displayed on the same screen by the trace waveform display means and the diagnostic parameter display means.   2. The ultrasonic Doppler diagnostic apparatus according to claim 1, wherein the diagnostic parameter display means displays a value of a diagnostic parameter measured in a latest heart beat section set in the trace waveform data by the section setting means. A step of detecting a Doppler signal by setting a desired range gate position for a reception signal obtained by performing ultrasonic transmission / reception on a subject;
Generating spectrum data for the Doppler signal;
Detecting a desired feature amount in the spectrum data, and generating a temporal change of the feature amount as trace waveform data;
Setting a plurality of heartbeat intervals for the trace waveform data;
A diagnostic parameter measuring method comprising: measuring diagnostic parameters in a predetermined heart beat section of the plurality of heart beat sections and highlighting the trace waveform data in the predetermined heart beat section. A step of detecting a Doppler signal by setting a desired range gate position for a reception signal obtained by performing ultrasonic transmission / reception on a subject;
Generating spectrum data for the Doppler signal;
Detecting a desired feature amount in the spectrum data, and generating a temporal change of the feature amount as trace waveform data;
Setting a plurality of heartbeat intervals for the trace waveform data;
Measuring a diagnostic parameter in a predetermined heartbeat interval of the plurality of heartbeat intervals;
Diagnostic parameter measurement comprising the steps of: freeze-displaying the latest measurement result of the trace waveform data and the diagnostic parameter, and highlighting the trace waveform data in the predetermined heartbeat interval where the latest measurement result is measured Method.

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