JP2005069847A - Organism optical measuring apparatus - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To shorten the time of mounting an optical fiber to be used for measurements to a subject on an organism optical measuring apparatus for measuring the concentration of metabolites of an organism or their concentration changes through the use of light. <P>SOLUTION: An arm attached to an organism optical measuring apparatus body is provided with a fixture for probes for a preparatory work. The fixture simulates the shape of a head part of the subject and has a variable shape, the probes are mounted onto the fixture, and optical fibers are connected to the probes. Since it is possible to perform the work of adjusting the probes prior to restraining the subject, it is possible to shorten the restraining time of the subject for measurements and improve the operating rate of the organism optical measuring apparatus. <P>COPYRIGHT: (C)2005,JPO&NCIPI

Description

  The present invention relates to a living body light measuring device that measures the concentration of a metabolite in a living body or a change in the concentration using light.

  It is Atsushi Maki that a technology (ecological light measuring device) that measures blood volume changes in the cerebral cortex due to brain activity at multiple points and displays the blood volume changes as moving images or still images has already been put into practical use. , Yuichi Yamashita, Yoshitoshi Ito, Eijiyu Watanabe, Yoshiaki Mayanagi, and Hideaki Koizumiti, and Spatially and temporally hysatology. 22 (No. 12), pp. 1997-2005 (1995) (non-patent document 1). The measurement technique disclosed in this document will be described below.

  FIG. 2 shows an apparatus configuration of a measurement method disclosed in the above literature. The subject 2-1 is equipped with a helmet (probe) 2-2 for measurement. This helmet is connected to an optical fiber 2-4 connected to a light irradiator 2-3 represented by a light emitting diode, a semiconductor laser and a lamp, and an optical detector 2-5 represented by an avalanche photodiode and a photomultiplier tube. In order to connect the optical fiber 2-6, an optical fiber holder 2-7 is provided. The optical fibers shown in 2-4 and 2-6 scrape the hair of the subject 2-1 and make light contact with the scalp. A plurality of the light irradiators 2-3 are provided, and the output light intensity with respect to each time is managed by the control device 2-9. The control content is also transmitted to the signal processing device 2-11 connected to the photodetector 2-5 via the transmission cable 2-10, and used for estimating the intensity change of the light that has passed through the living body. There is also. Reference numeral 2-12 denotes an electronic computer typified by a personal computer and a workstation, which determines the control contents to the control device 2-9 and takes in the processing result in the signal processing device 2-11 for analysis. To go. The analysis result is displayed on the screen shown in 2-12.

  FIG. 3 is an example of the analysis result shown in 2-12, and shows an image 3-1 called a topography image. As an example, this image shows a change in the concentration of a metabolite in the living body accompanying brain activity on the surface of the brain. Examples of in vivo metabolites to be measured include oxyhemoglobin, reduced hemoglobin, myoglobin and the like in the literature published so far. In addition, there is no problem even if the ratio of total hemoglobin (corresponding to the sum of changes in the concentration of oxidized hemoglobin and reduced hemoglobin), or the ratio of oxidized hemoglobin (or reduced hemoglobin) to this total hemoglobin is the sum of these substances. . The topographic image is displayed using a color bar (3-2) indicating the image and its density change. In addition, this image calculates the average value of the concentration change of the metabolite in the body from any time to any time during or before the brain activity period, and displays a static image with the distribution reconstructed. Alternatively, an animated moving image may be displayed.

It has been clarified so far that measurement of the language dominant hemisphere, measurement of the presence or absence of seizures by a long-time monitor, and the like can be performed using the biological light measurement devices shown in FIGS.
Tsuyoshi Yamamoto, Yuichi Yamashita, Hiroshi Yoshizawa, Atsushi Maki, Makoto Iwata, Eiju Watanae, Hideaki Koizumi, Non-invasive measurement of language function by using optical topography, Proceedings of SPIE, Vol. 3597 (pp. 230-237) (Non-patent Document 2) In the living body light measurement device described above, eight measurement optical fibers 4-1 connected to a light irradiator and 8 connected to a light detector are used. The measurement optical fibers are alternately arranged at intervals of 30 mm as shown in FIG. 4 (4-2). The approximate midpoint is set as a sampling point 4-3. In FIG. 4, sampling points are present at intervals of 21 mm in an area of 90 mm × 90 mm.
Sleep research using near-infrared spectroscopy, Yoshiken Amami et al., Nagai Shoten Clinical EEG, Vol. 42, No. 2 (2000), pages 74-79 (Non-patent Document 3) Has been reported on the measurement of brain activity.

Atsushi Maki, Yuichi Yamashita, Yoshitoshi Ito, Eijyu Watanabe, Yoshiaki Mayanagi, and Hideaki Koizumi, “Spatial and tempr. 22 (No. 12), pp. 1997-2005 (1995)

Literature Tsuyoshi Yamamoto, Yuichi Yamashita, Hiroshi Yoshizawa, Atsushi Maki, Makoto Iwata, Eiju Watanae, Hideaki Koizumi, Non-invasive measurement of language function by using optical topography, Proceedings of SPIE, Vol. 3597 (pp. 230-237) "Sleep research using near infrared spectroscopy", Yoshiken Amami et al., Nagai Shoten Clinical EEG, Vol. 42, No. 2 (2000), pages 74-79

  The comprehensive problem of the present invention is that the subject has to be inspected with a probe connected to a large number of optical fibers attached to the subject, or is subject to restraint on the subject during the examination preparation stage, It is to reduce the load. In the following, the above problems will be described as specific problems.

  The first specific problem is that even if there are a large number of optical fibers to be used (including optical fibers connected to the light irradiator and optical fibers connected to the light detector), they can be mounted on the device under test in a short time It is possible to provide a biological optical measuring device that is possible and that the optical fiber for measurement is less painful. For example, the probe described in the above-mentioned non-patent document 2 can measure a change in blood volume associated with brain activity in a language area (Broker area and Wernicke area) or a change in blood volume associated with brain activity in a motor area. I can do it. However, since the measurement area is limited, it is difficult to simultaneously measure and compare brain activity in the motor cortex and brain activity in the frontal lobe. Therefore, it is necessary to expand the measurement area. By expanding this measurement area, the number of optical fibers increases and a new problem arises. FIG. 5 shows an optical fiber 5-1 connected to a light irradiator used for measurement, an optical fiber 5-2 connected to a photodetector, an optical fiber holder 5-3 for fixing these optical fibers, and this light. The relationship of the probe 5-5 that fixes the fiber and is attached to the inspection object 5-4 is illustrated. In order to start measurement, it is necessary to fix an optical fiber to the probe 5-5 (hereinafter referred to as a helmet because it is mounted on the head). This can be roughly divided into two methods. In the first method, first, a helmet is fixed to an object to be inspected, and then an optical fiber for measurement is attached to an optical fiber holder on the helmet. Accordingly, the preparation time becomes longer as the number of optical fibers to be attached increases as the subject is more restrained in the measurement preparation stage. The second method is a method in which an optical fiber used for measurement is first attached to the optical fiber on the helmet, and then this helmet is attached to the subject. In this second method, since the optical fiber is fixed in advance, measurement can be started simply by wearing a helmet on the subject. However, in this second method, as shown in FIG. 6, the work of detaching the optical fiber from the helmet is performed with the helmet 6-1 to which the optical fiber holder is fixed suspended by the measurement optical fiber 6-2. Or wait for the subject to arrive. At this time, the weight of the helmet or the optical fiber holder is applied to the attached optical fiber itself or to the connection portion of the optical fiber holder, and as a result, the optical fiber is easily broken.

  The second specific problem is to provide a biological light measurement device that takes into account cases of long-time measurement and seizures during measurement, and more specifically, the inspected body and the biological light measurement device. An object of the present invention is to provide a structure in which the optical fiber connecting the main bodies can be easily connected or disconnected. It has become possible to measure seizures typified by epilepsy using a biological light measurement device. For this measurement, or for the measurement of brain activity during sleep described in the introduction of Non-Patent Document 2 above, the subject to be inspected wears a helmet with a measurement optical fiber fixed for a long time. There is a need. For example, if the subject leaves the examination site temporarily, such as going to the toilet, if the helmet with an optical fiber is removed from the head and then exited, the measurement position will be the same as when the examination is started again. Is difficult. Also, it takes time and effort to reproduce a good contact state between the tip of each optical fiber and the scalp. Therefore, a structure that can easily cope with the withdrawal of the subject during the examination is required. Furthermore, when a seizure occurs during measurement, a structure is required that allows a doctor or nurse to easily perform treatment or care by quickly opening the object to be inspected from a state where it is connected to the biological light measurement device with an optical fiber. .

  A third specific problem is to provide a living body light measurement device in which an object to be inspected hardly senses the weight of an optical fiber or a helmet. In many cases, the subject to be inspected sits on a chair or sleeps on a bed. At this time, a measurement method for fixing the optical fiber is necessary so that the object to be inspected does not feel the weight of the optical fiber.

The first feature of the biological optical measurement device according to the present invention is that the probe that is connected to the tip of the optical fiber and must be attached to the inspected object at the time of measurement can be temporarily placed at the position where the inspected object should be seated, Biological light equipped with a probe fixture (helmet holder) that enables connection of an optical fiber and adjustment of the probe in a temporarily placed state and can be moved away from the vicinity of the subject after the probe is attached to the subject. In the measuring device.
The second feature of the biological optical measurement device according to the present invention is an optical fiber that guides the irradiation light from the light irradiator of the inspection apparatus body to the object to be inspected and an optical fiber that guides the detection light to the photodetector of the inspection apparatus body. The probe side part and the inspection apparatus side part to be mounted on the object to be inspected are divided and connected to each other by a connector provided with a coupling device represented by a magnet.
A third feature of the biological optical measurement device according to the present invention is that a chair or a bed on which an object to be inspected sits for measurement includes a holder that holds an optical fiber bundle connected to a probe attached to the object to be inspected. A biological light measurement device is provided.

According to the present invention, before the object to be inspected is seated at the measurement position, it is possible to stably temporarily place the measurement probe near the position and connect a large number of optical fibers to the probe in that state. Furthermore, adjustments such as holding the connected optical fiber bundle in an appropriate state can be performed by holding the probe at a position where the object to be inspected, so that the adjustment work after the object is seated can be reduced. . Therefore, the restraint time of the object to be inspected can be shortened.
Furthermore, by using a connector, the object to be inspected can be temporarily with the probe attached during measurement, and when the measurement is resumed, the original measurement position and contact state can be quickly reproduced only by connecting the connector. Even when treatment or care other than biological light measurement is urgently needed, the connector can be disconnected to quickly release the inspected object from the state connected to the biological light measurement device, and the necessary treatment and care can be performed quickly. .
In addition, the use of a fixture that holds the optical fiber bundle can reduce the load on the object to be inspected.

Embodiments according to the present invention will be described below.
FIG. 1 is a diagram showing a device configuration of a biological light measurement device according to the present invention. Reference numeral 1-1 denotes a biological light measuring device main body including a plurality of light irradiators represented by lamps, light emitting diodes, and semiconductor lasers, and a plurality of light irradiators represented by photodiodes and photomultiplier tubes. This biological light measurement device includes an input device 1-2 represented by a keyboard and a mouse, and a display device 1-3 that can display measurement results. Since this biological light measuring device includes wheels 1-4, it can move and has high mobility. Furthermore, this living body light measurement apparatus includes an optical waveguide 1-5 represented by an optical fiber connected to the light irradiator or the photodetector, and a column 1-6 that can fix an optical fiber bundle holder described later. It has. Reference numeral 1-7 denotes an optical fiber bundle holder that holds an optical fiber bundle, and can hold a plurality of optical fibers. The optical waveguide 1-5 is connected to the optical waveguide 1-11 in contact with the device under test through the optical waveguide connector 1-10 in the vicinity of the device under test 1-9 on the bed 1-8. . In addition, a measurement probe 1-10 is attached to the head of the inspection object 1-9 on the bed 1-11. The probe 1-10 has a structure in which the tip of the optical fiber 1-11 is arranged and fixed so that the tip of the optical fiber 1-11 comes into contact with the scalp of the subject. Since this probe is usually for head mounting, it will be called a helmet hereinafter.

FIGS. 7A and 7B show an embodiment of a biological light measurement device having a helmet holder which is a solution to the first problem described above. An arm 7-2 is connected to the biological light measuring device body 7-1. The arm 7-2 has a multi-joint structure, and a fixed base 7-5 for placing a helmet 7-4 to be attached to a subject to be examined (subject's head) at the time of measurement is attached to the tip of the arm. Yes.
The helmet 7-4 is used by being connected to a plurality of optical fibers 7-3 for introducing irradiation light from the biological light measurement device main body 7-1 and for guiding detection light to the biological light measurement device main body 7-1. . From the request to replace only the helmet part according to the object to be inspected, or to change the connection position of each optical fiber on the helmet according to the measurement site, preparation work to attach the optical fiber to the helmet is If necessary, it often occurs. In the present embodiment, it is possible to perform an operation of attaching the optical fiber 7-3 used for measurement to the optical fiber holder on the helmet in a state where the helmet is placed on the fixed base 7-5. Therefore, it becomes possible to fix the optical fiber to the helmet before the subject arrives, and as soon as the subject arrives, the helmet can be worn and measurement can be started. If this helmet fixing base is not provided, one method is to first attach the helmet to the subject and then attach the optical fiber to the helmet, but this method increases the restraint time of the subject. There is also a method of connecting the optical fiber to the optical fiber holder of the helmet before the arrival of the subject. However, without a fixed base, it is difficult to attach the optical fiber to the helmet. Even if the optical fiber can be mounted, work force is applied to the optical fiber that has already been mounted when each optical fiber is mounted. In addition, since the optical fiber is hung with the helmet connected, a load of the helmet is applied to the optical fiber. As a result, the optical fiber is strongly subjected to mechanical force, and as a result, it is considered that the disconnection of the optical fiber and the deterioration of the optical fiber holder are accelerated.
Furthermore, this embodiment is characterized in that the spatial position of the fixed base 7-5 can be changed and held by employing an articulated arm. After the optical fiber is connected to the helmet, it may be necessary to perform operations such as bundling the many optical fibers into one, and further fixing the bundle to the arm. It is desirable that these operations including the installation of the optical fiber (helmet adjustment operation) be performed at the position where the subject actually wears the helmet during measurement. If it does so, the adjustment work after putting a helmet on a test subject can be reduced. In this embodiment, as shown in FIG. 7 (a), adjustment is performed while holding the helmet at or near the position where the subject's head should come during measurement, and is fixed during measurement as shown in FIG. 7 (b). It is easy to move the table to a position that does not hinder measurement. Furthermore, since the position of the helmet can be spatially changed, it is advantageous also in the case of sequentially measuring the brain functions of subjects having different heights.
Further, in the embodiment of FIG. 7, the arm is provided with a hook-like projection 7-6, and a helmet as shown in FIGS. 8A and 8B can be hooked. For example, in the helmet 8-1 shown in FIG. 8A, the string 8-2 is attached to a part of the side of the helmet. In the helmet shown in 8-2, a large number of holes are provided in the base. In these helmets, it is possible to suspend the helmet removed from the object to be inspected immediately after the measurement, to the protruding portion of the arm.

  Next, a modified example of the fixing base shown in FIG. 7 is shown in FIG. In FIG. 9, the spatial position of the fixing base can be changed as in FIG. 7, but the feature is that the shape of the fixing base changes compared to FIG. 7. The fixed base 9-1 is also composed of a stretchable member such as rubber or vinyl, and the shape is changed using a pump 9-2 having the shape at the bottom. Description will be made using the usefulness of the fixing base for the biological optical measurement device having such a variable shape (FIG. 10). FIG. 10 shows a diagram in which a test subject 10-1 wears two helmets 10-2 and 10-3 and measures brain function. In the figure, helmets are respectively attached to the right and left hemisphere temporal heads. For example, helmets may be attached to the left hemispheric temporal and frontal lobes, and there are various positions and numbers. Here, since the shape (size) of a head changes with people, it is necessary to adjust the length of the belt 10-4 which has connected two helmets so that it may suit a test subject. If the shape of the fixed base is variable, the helmet interval can be easily adjusted according to the size of the head. As a result, it is possible to shorten the time interval between measurements, such as when measuring an adult immediately after measuring a child's brain function.

  FIG. 11 shows another example of the biological optical measurement device fixture having a variable shape and size. FIG. 11A is a top view and FIG. 11B is a perspective view. This fixture is composed of four parts 11-1, 11-2, 11-3, 11-4 composed of a hard material such as resin or metal, and a resin material such as rubber or vinyl that connects them. It consists of parts 11-5, 11-6, 11-7, and 11-8. A mechanism for adjusting the distance between the parts made of the hard material is provided inside, and 11-9 indicates a screw for this adjustment. Thereby, the whole shape or size can be changed. FIG. 11C shows a state in which the size is increased.

  Next, a specific example of the optical fiber connector 1-10 shown in FIG. 1 will be described with reference to FIGS. The connector shown in FIG. 12 has a structure in which four bundle optical fibers can be connected together. The arrangement shape of the bundle optical fibers is a square shape in the figure, but may be any other shape without any problem. Also, the number is not limited to four. In one of the paired connector main bodies 12-1 and 12-2, in 12-1, a bundle optical fiber is fixed to a pedestal 12-3 protruding about 1 mm to 30 mm from the surface of the main body. The tip position of the bundle optical fiber substantially coincides with the position of the surface of the pedestal. In the other connector main body 12-2, the bundle optical fiber is fixed to the concave portion 12-5 having a shape corresponding to the pedestal 12-3. By fitting the pedestal of the connector main body 12-1 into the recess of the connector main body 12-2, the optical fibers at the corresponding positions are coupled to each other. Further, in this connector, magnets 12-6 are provided at corresponding positions on the joint surfaces of the connector main bodies 12-1 and 12-2, respectively, so that the fibers can be kept in good contact with each other so that they cannot be removed by a slight tensile force. In addition, a plurality of requirements such as making it easy to remove and attach are simultaneously solved.

  Next, a modification of the optical fiber connector for a biological light measurement device will be described with reference to FIG. The difference between the configuration of the connector shown in FIG. 13 and the configuration of the connector shown in FIG. 12 is the following two points. The first point is that each of the paired connector main bodies includes both a convex base and a concave portion. As a result, the force applied to each connector becomes more uniform, and it becomes possible to suppress wear of the pedestal of each connector. The second point is that a plurality of magnets are provided at positions symmetrical with respect to the center of each connector connection surface in each connector shown in FIG. On the other hand, the connector shown in FIG. 13 has no central symmetry of the arrangement position. As a result, the connection surface of the connector is asymmetrical in the vertical and horizontal directions, and connection errors can be prevented. For example, in FIG. 13, the tip of the bundle optical fiber 13-1 can always be connected to the tip of the bundle optical fiber 13-2.

  Next, a further modification using the optical fiber connector shown in FIGS. 12 and 13 will be described. FIG. 14 shows an optical fiber-related configuration of the biological light measurement device capable of cutting the optical fiber connector shown in FIGS. 12 and 13 in accordance with a detection signal from the biological light measurement device. Reference numeral 14-1 denotes a housing including the biological light measurement device. In this housing, a photodetector (2-5) and a light irradiator, which are components of the biological light measurement device shown in FIG. (2-8), a control device (2-9), and a signal processing device (2-11). 14-2 and 14-3 are optical fibers used for measurement. Although not shown in this figure, one end of the optical fiber 14-2 is brought into contact with the skin of the subject, and the other end is 14 using optical fiber connectors (14-4, 14-5). 3 is connected to the optical fiber (14-3) shown in FIG. Then, the other end of the optical fiber (14-3) is connected to a light irradiator or a photodetector provided in a housing including the biological light measuring device shown in 14-1. Reference numeral 14-6 denotes a cable characterized by connecting the control device of the biological light measurement device and any one of the optical fiber connectors 14-4 and 14-5. The role of this cable will be described below with reference to FIGS. FIG. 15 is an input screen on the display device (14-8) provided on the housing (14-1) of the biological light measurement device shown in FIG. When the brain function is measured using the input device (14-9, for example, a keyboard or a mouse) provided in the housing (14-1) of the biological light measurement device shown in FIG. The rest time (15-1), the stimulation time (15-2), the number of repetitions of stimulation (15-3), and the like, which are necessary to be set, are input, and the threshold value (15-4) is input. On this screen, a change in blood volume that changes per unit time is set, but in addition to this, it is possible to input a change in the intensity of light that has passed through the living body that changes per unit time. When a change exceeding this input result is detected, the control device issues a signal and is provided inside the optical fiber connector (16-2) for biological light measurement device via the cable (16-1) shown in FIG. The magnetic force of the electromagnet (16-3) is eliminated. As a result, the two optical fiber connectors (16-2 and 16-4 described above) shown in FIG. 16 are disconnected from the coupled state.

Next, the Example which provides the biological-light measuring device in which a to-be-inspected object hardly senses the weight of an optical fiber or a helmet is demonstrated using FIGS. FIG. 17 shows an optical fiber bundle holder, and this optical fiber holder is used by being fixed to the hypothetical bed 1-11 shown in FIG. 1 or the arm 7-2 shown in FIG. Reference numerals 17-1 and 17-2 denote members for fixing the optical fiber bundle holder to the bed or the arm. By adjusting the distance between them, the optical fiber bundle holder is fixed to the arm, for example. Reference numeral 17-3 denotes a support portion whose height, rotation angle, turn angle and the like are variable, and the spatial positional relationship of the holding portion 17-4 existing on the upper portion of the support portion can be changed. ing. The inside of the holding portion is made of a resin material or metal having a high coefficient of friction represented by rubber or vinyl. Moreover, the holding part has a structure that can be opened and closed, and the holding part is closed using the holding fixture 17-5. As a result, it is possible to hold an arbitrary position of the optical fiber 17-6 and fix the holding direction in an arbitrary direction.
FIG. 18 shows how this holder is used in actual measurement. In FIG. 18, a helmet (18-4) connected with a plurality of optical fibers 18-3 is attached to an inspected object 18-2 seated on a chair 18-1, and light is further emitted by an optical fiber bundle holder 18-5. A state in which the fiber 18-3 is fixed is shown. By adjusting the position of the holding portion 18-7, the hold position of the optical fiber (the optical fiber length ahead of the hold position), and the holding direction, it was possible to realize an optimum state for the object to be inspected. That is, the optical fiber is not bent between the holding part and the helmet, and as a result, the weight of the optical fiber and the helmet felt by the object to be inspected can be reduced as much as possible.

It is a flock figure which shows the whole structure of the biological light measuring device of one Example of this invention. It is an apparatus block diagram of the conventional biological light measuring device. It is a figure which shows an example of the measurement and analysis result using a biological light measuring device. It is a figure which shows the arrangement | positioning method of the optical fiber connected to the light irradiation device and the photodetector. It is a conceptual diagram which shows the mounting method of the optical fiber and a helmet to a to-be-inspected object. It is a figure which shows the helmet after connecting an optical fiber. It is a figure which shows the structure of the helmet holder of an Example. It is a figure which shows the structure of the helmet of an Example. It is a figure which shows the modification of a helmet holder. It is a figure which shows the fixing method of the helmet to a to-be-inspected object. It is a figure which shows the other modification of a helmet holder. It is a figure which shows the optical fiber bundle connector of an Example. It is a figure which shows another example of an optical fiber bundle connector. It is a figure which shows another example of an optical fiber bundle connector. It is a figure which shows the input screen on the display apparatus 14-8 with which the Example is equipped. It is a figure which shows the structure of the further 14-4 of the optical fiber bundle connector of FIG. It is a figure which shows the optical fiber bundle holder of an Example. It is a figure which shows the use condition of the said optical fiber bundle holder.

Explanation of symbols

1-1: Living body optical measurement device main body, 1-2: Input device, 1-03: Display device, 1-4: Wheel, 1-5, 1-11: Optical waveguide, 1-6: Support column, 1-7 : Optical fiber bundle holder, 1-8: Bed, 1-9: Object to be inspected, 1-10: Optical waveguide connector,
2-1: Inspected object, 2-2: Helmet (probe), 2-3: light irradiator, 2-4, 2-6: optical fiber, 2-5 photodetector, 2-7: optical fiber Holder, 2-9: control device, 2-10: transmission cable, 2-11: signal processing device, 2-12: screen,
3-1: Topography image,
4-1: Measurement optical fiber connected to light irradiator, 4-2: Measurement optical fiber connected to photodetector, 4-3: Sampling point 5-1: Optical fiber connected to light irradiator, 5 -2: Optical fiber connected to the photodetector, 5-3: Optical fiber holder for fixing the optical fiber, 5-5: Helmet,
6-1: helmet, 6-2: optical fiber for measurement,
7-1: Living body light measuring device main body, 7-2: Arm, 7-3: Optical fiber, 7-4: Helmet, 7-5: Fixing base, 7-6: Hook 8-1, 8-3: Helmet , 8-2: String,
9-1: Fixing base, 9-2: Pump 10-2, 10-3: Helmet, 10-4: Belt,
11-1, 11-2, 11-3, 11-4: site portion of hard material ,: 11-5, 11-6, 11-7, 11-8: site of resin material, 11-9: shape Adjustment jig,
12-1, 12-2: Connector body, 12-3: Base, 12-5: Recess, 12-6: Magnet,
13-1, 13-2: bundle optical fiber,
14-1: Case including biological light measurement device, 14-2: Optical fiber, 14-3: Optical fiber, 14-4: Connector for optical fiber, 14-5: Connector for optical fiber, 14-6: Cable 16-1: Cable, 16-2, 16-4: Optical fiber connector main body, 16-3: Electromagnet,
17-1, 17-2: fixing member, 17-3: support portion, 17-4: holding portion, 17-5: holding fixture, 17-6: optical fiber,
18-1: Chair, 18-3: Optical fiber, 18-4: Helmet, 18-5: Optical fiber bundle holder, 18-6: Holding part.

Claims (7)

A plurality of light irradiators, a plurality of light detectors, and these light irradiators, and optical fibers optically coupled to the light detectors, and the ends of the optical fibers of the inspected object In a biological optical measurement device that is connected to a probe that is arranged and held in contact with the body surface, and that measures the metabolite concentration in the living body with light by attaching the probe to a test object,
Imitates the shape of the living body at the tip of the arm extending from the living body optical measurement device body, and includes a fixture for temporarily mounting the probe;
A biological light measurement device characterized in that the spatial position and shape of the fixture are variable.   The biological optical measuring device fixture according to claim 1, wherein the fixture is made of a resin material.   The fixture for a biological optical measurement device according to claim 1, wherein the fixture has an outer shape that is changed by air pressure or mechanically. A plurality of light irradiators, a plurality of light detectors, and an optical waveguide that guides irradiation light from each light irradiator to the object to be inspected, and guides detection light from a measurement point of the object to be inspected to each light detector. And a biological light measurement device including a probe that is arranged and held on the tip of the optical waveguide and is attached to the object to be inspected,
The optical waveguide is configured by connecting a first optical fiber bundle on the main body side of the biological light measurement device and a second optical fiber bundle on the probe side by a connector;
The living body optical measuring device characterized in that the connector has a magnet that maintains a connection by magnetic force and maintains optical coupling between the first and second optical fiber bundles.   The biological light measuring device according to claim 4, wherein the connector includes a member whose shape of the connection surface is not contrasted. A plurality of light irradiators, a plurality of light detectors, and an optical waveguide that guides irradiation light from each light irradiator to the object to be inspected, and guides detection light from a measurement point of the object to be inspected to each light detector. And a biological light measurement device including a probe that is arranged and held on the tip of the optical waveguide and is attached to the object to be inspected,
A living body light measurement apparatus comprising: a holder that is detachably attached to a fixing member on which the object to be inspected is seated, and that holds the optical waveguide. The biological light measuring device according to claim 6, wherein the holder is fixed so that the direction of the optical waveguide and the length from the fixing position can be adjusted.

Images