JP2005040477A - Packed ophthalmic solution - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To provide an injection type (backflow preventing type) packed ophthalmic solution prevented from administering the solution in the quantity more than necessary while hardly diffusing the solution when administered. <P>SOLUTION: The packed ophthalmic solution is prepared by filling compressed gas and the solution in a container provided inside with an injection valve mechanism for opening/closing a passage leading to an external nozzle by button operation. The injection valve mechanism is controlled to spout the solution of 40-170 mg in a drop state whenever the passage is opened once or whenever the passage is opened for one second. <P>COPYRIGHT: (C)2005,JPO&NCIPI

Description

  The present invention relates to a multi-use packaged eye drop that can prevent secondary contamination without adding a preservative into the solution.

Ordinary multi-use pre-packaged eye drops flow back into the container after administration (use) or at the vicinity of the extraction port. If no preservative is added to the liquid, secondary contamination will occur. It cannot be prevented.
As a multi-use packaged eye drop that can prevent secondary contamination without adding a preservative to the solution, a solution filled with an aerosol container so that the solution does not flow back has been proposed (for example, (See each patent document below).

The packaged eye drops filled with the liquid agent in the aerosol container described above can prevent secondary contamination from the liquid agent and tear liquid not flowing back into the container from the injection port side, and without adding a preservative to the liquid agent. .
However, according to the conventional aerosol-type packaged eye drops, the liquid agent diffuses when sprayed and adheres to the surroundings of the eye, and more than the required amount of liquid agent is not administered. There was no.
Japanese Utility Model Publication No. 43-11599 Registered Utility Model No. 3018401 Japanese Utility Model Publication No. 54-55196

  An object of the present invention is to provide an injection-type (backflow prevention type) packaged eye drop that does not easily diffuse during administration and does not administer more than the required amount of solution.

  One of the packaged eyedrops according to the present invention is a method in which a compressed gas and a liquid agent are filled in a container provided with an injection valve mechanism that opens and closes a flow path leading to an external injection port by a button operation. The mechanism is provided with a metering chamber in which the liquid agent in the container flows when the flow path is closed and the flow of the liquid agent in the container is blocked when the flow path is opened. Each time the flow path is opened through the measuring chamber, 40 to 170 mg of liquid agent is controlled to be ejected in a droplet state.

  Another one of the packaged eye drops according to the present invention is filled with a compressed gas and a liquid agent in a container provided therein with an injection valve mechanism that opens and closes a flow path that communicates with an external ejection port by a button operation, The injection valve mechanism is provided with a flow rate suppressing means for suppressing the outflow amount of the liquid agent when the flow path is opened, and the injection valve mechanism is provided every time the flow path is opened for one second through the flow rate suppressing means. It is characterized in that it is controlled so that ˜170 mg of liquid is ejected in the form of droplets.

The packaged eye drops according to the present invention can always eject a fixed amount of liquid by a button operation, and the dosage of the liquid does not become excessive.
Further, since the gas in the container is not a liquefied gas but a compressed gas, the liquid agent ejected from the ejection port is not in the form of a mist but in the form of droplets, so that the liquid agent does not diffuse and adhere to the periphery of the eye It is administered in a preferred state.
Since the container is filled with the compressed gas together with the liquid agent, it is completely pushed out from the jet nozzle by the pressure of the compressed gas, and does not flow back into the container, so that it is not necessary to add a preservative to the liquid agent.

Hereinafter, a preferred embodiment of a packaged eye drop according to the present invention will be described with reference to the drawings.
1st Embodiment FIG. 1: is a partial longitudinal cross-sectional view of the packaged eyedrops of 1st Embodiment.
The pressure-resistant container 1 includes a bottomed cylindrical main body 10 and a lid 11 that seals the upper portion of the main body 10, and contains a compressed gas (for example, nitrogen gas, oxygen, air, carbon dioxide gas). Etc.) and liquids (eye drops) are filled.
Inside the lid 11, an injection valve mechanism 2 that opens and closes a flow path 31 of an external ejection nozzle 3 having an ejection port 30 is provided. The ejection nozzle 3 also serves as an operation button 3 a for operating the ejection valve mechanism 2.

The injection valve mechanism 2 has a bottomed cylindrical housing 20 with an upper end attached to the center of the lid 11, and is inserted through the center of the lid 11 into the housing 20 so as to be movable in the axial direction with a predetermined stroke. The valve stem 21 is provided.
The upper end portion of the housing 20 is fixed in a caulking shape in an inverted cup-shaped attachment portion 12 formed at the center portion of the lid 11, and a gasket or the like is provided between the upper bottom portion of the attachment portion 12 and the upper end of the housing 20. A ring plate-shaped sealing material 22 is interposed.
The valve stem 21 is prevented from coming off from the upper bottom portion of the mounting portion 12 by passing through the sealing material 22 in a state where the inner edge of the sealing material 22 is accommodated in the constricted portion 21a. The coil spring 23 disposed between the inner bottom of the housing 20 is always urged upward.

A communication hole 24 that communicates with the flow path 31 of the ejection nozzle 3 is formed in the upper portion of the valve stem 21.
In this embodiment, the small hole 25 formed to communicate with the communication hole 24 in the constricted portion 21 a of the valve stem 21 and the sealing material 22 that closes the small hole 25 are the first valve portion of the injection valve mechanism 2. 2a.
A valve piece 26 provided at a lower portion of the valve stem 21 and a communication hole 27 formed so as to communicate with the inside of the container 1 at the bottom of the housing 20 constitute a second valve portion 2b of the injection valve mechanism 2. The inner space of the housing 20 (the space excluding the portion occupied by the valve stem 21 and the valve piece 26 in the housing 2) constitutes a measuring chamber 2c.
The mutual relationship between the first valve portion 2a and the second valve portion 2b is such that when one is opened, the other is closed.

  Since the packaged eye drop of this embodiment is an upright use form used in an upright state, the lower end of the housing 20 communicates with the communication hole 27 and reaches the inner bottom of the container body 10. A tube 28 for attracting is attached.

In this embodiment, the pressure (internal pressure) of the compressed gas in the container 1 is preferably adjusted to about 0.4 to 0.6 MPa. .
In addition, the inner space of the housing 20 that is the measuring chamber 2c is about 40 to 170 mg of the liquid agent in the container 1 in a state where the first valve portion 2a is closed and the second valve portion 2b is opened. The volume is designed to flow into the measuring chamber 2c. A liquid dosage of 40 to 170 mg is an appropriate dose when usually using eye drops or the like.

In the packaged eye drop of the first embodiment, when the operation button 3a that also serves as the ejection nozzle 3 is pushed in the direction of the container 1 with a finger in the state shown in the drawing, the first valve portion 2a is opened and the second valve portion 2b is opened. Since it closes, the liquid agent for the volume of the measurement chamber 2c is ejected from the ejection port 30. On the other hand, when the finger is released from the operation button 3a, the first valve portion 2a is closed and the second valve portion 2b is opened as shown in the figure, so that the liquid agent in the container 1 flows into the measuring chamber 2c. That is, each time the flow path 31 is opened once through the measuring chamber 2c of the injection valve mechanism 2, 40 to 170 mg of the liquid agent is controlled to be ejected in a droplet state.
Therefore, a fixed amount of liquid is always ejected by button operation, and the dosage of liquid does not become excessive.
Moreover, since the gas in the container 1 is not a liquefied gas but a compressed gas, the liquid agent ejected from the ejection port 30 is not in the form of a mist but is in a droplet state.
Therefore, the liquid agent is administered in a preferable state without diffusing and adhering around the eye.
Since the container 1 is filled with the compressed gas together with the liquid agent, the liquid agent in the measuring chamber 2c is completely pushed out from the jet port 30 by the pressure of the compressed gas, and does not flow back into the container 1, and therefore, into the liquid agent. There is no need to add preservatives.

2nd Embodiment FIG. 2: is a partial longitudinal cross-sectional view of the packaged eyedrops of 2nd Embodiment.
Since the packaged eye drop of this embodiment is an inverted use form used upside down or in a state where the ejection nozzle 3 is inclined downward, the ejection nozzle 3 having the operation button 3a is in an upright state or in a state where it is inclined upward. Configured.
The lid 11 of the container 1 is formed in a flat shape instead of a dish shape as in the first embodiment.
The second valve portion 2 b that opens and closes between the measuring chamber 2 c and the inside of the container 1 includes a communication hole 27 formed in a sliding region of the valve stem 21 on the side wall portion of the housing 20 and a longitudinal groove of the valve stem 21. It is comprised with the peripheral surface part 21b which is not formed.
Since it is configured as described above, when one of the first valve portion 2a and the second valve portion 2b is closed, the other is opened by the operation of the operation button 3a. Moreover, the amount of the liquid remaining in the container 1 when it is used becomes a small amount, and there is no waste.
Since other configurations and operational effects of the packaged eye drop of this embodiment are the same as those of the first embodiment, description thereof will be omitted.

3rd Embodiment FIG. 3: is a partial longitudinal cross-sectional view of the packaged eyedrops of 3rd Embodiment.
In this embodiment, the inner space of the housing 20 is not used as a measuring chamber, but the flow rate suppressing means 2d including an orifice having a small flow cross section is provided at the bottom of the housing 20.
Depending on the size of the cross-sectional area of the flow rate restraining means 2d, the injection valve mechanism 2 causes the injection valve 30 to open from the outlet 30 every time the first valve portion 2a is opened and the interior of the container 1 and the flow path 31 of the injection nozzle 3 communicate with each other for one second. It is controlled so that 40 to 170 mg of liquid agent is ejected in a droplet state.
In order for the injection valve mechanism 2 to be controlled as described above, when the internal pressure of the container 1 is set to about 0.4 to 0.6 MPa, the sectional area of the orifice constituting the flow rate suppressing means 2d is set to 0.01 to It is about 0.06 mm.

Since the packaged eye drop of the third embodiment is configured as described above, a fixed amount of liquid is ejected each time the operation button 3a is pressed for one second, and the liquid that is ejected is not a mist but a droplet.
The other configurations and functions and effects of the packaged eye drop of the third embodiment are almost the same as those of the first embodiment, and thus the description thereof is omitted.

4th Embodiment FIG. 4: is a partial longitudinal cross-sectional view of the packaged eyedrops of 4th Embodiment.
This embodiment shows a modification of the flow rate suppressing means 2d with respect to the third embodiment, and the communication hole 27 formed in the bottom of the housing 20 is closed with a continuous porous member, a fibrous member, or a net-like member. The suppressing means 2d is used.
Other configurations and effects of the packaged eye drop of this embodiment are substantially the same as those of the third embodiment, and thus description thereof is omitted.

5th Embodiment FIG. 5: is a partial longitudinal cross-sectional view of the packaged eyedrops of 5th Embodiment.
The packaged eye drop of this embodiment is an inverted usage pattern similar to the second embodiment, and the basic configuration of the container 1, the ejection nozzle 3, the operation button 3a and the housing 20 is the same as that of the second embodiment. The basic configuration of the valve stem 21 is the same as that of the third embodiment.
An orifice having a small cross-sectional area is formed in the peripheral wall portion of the housing 20, and this is used as the flow rate suppressing means 2d.

Similarly to the third embodiment, the packaged eye drop of the fifth embodiment ejects a fixed amount of liquid every time the operation button 3a is pressed for one second, and the liquid to be ejected is not a mist but a droplet. .
Other functions and effects of the packaged eye drop of this embodiment are substantially the same as those of the second embodiment, and thus description thereof is omitted.

6th Embodiment FIG. 6: is a partial longitudinal cross-sectional view of the packaged eyedrops of 6th Embodiment.
This embodiment shows a modification of the flow rate suppressing means 2d with respect to the fifth embodiment, and the communication hole 27 formed in the peripheral wall portion of the housing 20 is closed with a continuous porous member, a fibrous member, or a net-like member. The flow rate suppressing means 2d is used.
Since the other configurations and effects of the packaged eye drop of this embodiment are substantially the same as those of the fifth embodiment, description thereof will be omitted.

Other Embodiments In the packaged eye drop of the embodiment of FIG. 3, instead of forming the orifice in the housing 20 of the injection valve mechanism 2 or forming the orifice in the housing, for example, as shown in FIG. An orifice made of a tube 28 having a small inner diameter can be provided in this portion, and this can be used as the flow rate suppressing means 2d. Further, the flow rate suppressing means 2d can be constituted by a continuous porous member, a fibrous member or a net-like member as shown in FIGS. 4 and 6, and an orifice as shown in FIGS.
In the packaged eye drops of the embodiment of FIGS. 1, 3 and 4, the ejection nozzle 3 is configured substantially the same as that of the embodiment of FIG. If the tube is a flexible tube that bends following changes, the packaged eye drops can be used in an inverted state.

It is a partial longitudinal cross-sectional view of the packaged eyedrops of 1st Embodiment which concerns on this invention. It is a partial longitudinal cross-sectional view of the packaged eye drop of 2nd Embodiment which concerns on this invention. It is a partial longitudinal cross-sectional view of the packaged eye drop of 3rd Embodiment which concerns on this invention. It is a partial longitudinal cross-sectional view of the packaged eye drop of 4th Embodiment which concerns on this invention. It is a partial longitudinal cross-sectional view of the packaged eye drop of 5th Embodiment which concerns on this invention. It is a partial longitudinal cross-sectional view of the packaged eye drop of 6th Embodiment which concerns on this invention. It is a fragmentary longitudinal cross-section which shows other embodiment of the packaged eyedrop which concerns on this invention.

Explanation of symbols

DESCRIPTION OF SYMBOLS 1 Container 10 Main body 11 Lid 12 Attachment part 2 Injection valve mechanism 20 Housing 21 Valve stem 21a Constriction part 21b Circumferential surface part 22 Sealing material 23 Coil spring 24 Communication hole 25 Small hole 26 Valve piece 27 Communication hole 28 Tube 2a 1st valve part 2b Second valve portion 2c Measuring chamber 2d Flow rate suppressing means 3 Ejection nozzle 3a Operation button 30 Ejection port 31 Flow path

Claims (2)

When a button is operated, a compressed gas and a liquid agent are filled in a container provided with an injection valve mechanism that opens and closes a flow path that communicates with an external ejection port. When the flow path is closed, the container is filled in the injection valve mechanism. A metering chamber is provided in which the inflow of the liquid agent in the container is blocked when the liquid agent flows in and the flow path is opened, and the injection valve mechanism is provided each time the flow path is opened through the measurement chamber. A packaged eye drop characterized by being controlled so that 40 to 170 mg of liquid is ejected in the form of droplets. Compressed gas and liquid agent are filled in a container provided with an injection valve mechanism that opens and closes a flow path that leads to an external jet port by a button operation, and when the flow path is opened in the injection valve mechanism, the liquid agent The flow rate control means for suppressing the outflow amount of the liquid is provided, and the injection valve mechanism is controlled so that 40 to 170 mg of liquid agent is ejected in a droplet state every time the flow path is opened for one second through the flow rate control means. Packaged eye drops characterized by that.

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