JP2005029525A - Skin care preparation for external use containing silicone as essential component - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To provide a skin care preparation for external use, containing a silicone as an essential component, and having both of a pharmacological activity of the silicone, and a pharmacological activity of chitosan. <P>SOLUTION: This skin care preparation for external use is obtained by formulating a silicone material or a solution containing the silicone material as a main material, and the chitosan. In another aspect, the skin care preparation for external use is obtained by formulating the silicone material or the solution containing the silicone material as the main material, the chitosan, and a material for increasing a negative static voltage. The silicone material is preferably of an oil shape, a gel shape or a cream shape in the skin care preparation for external use. The solution containing the silicone material as the main material is preferably an aqueous solution or a milky lotion having ≤15% content of water. <P>COPYRIGHT: (C)2005,JPO&NCIPI

Description

  The present invention relates to an external preparation for skin obtained by adding the pharmacological action of chitosan to the pharmacological action of silicone.

Silicone does not regenerate the skin by applying the wound, keloid swell, twitching, hardness, color, pain, itch, etc. to the local area, but it normalizes the skin, more specifically, the compression effect, moisturizing by covering It is known that there is an effect, normalization by removing local overstimulation due to the negative electrostatic potential of the silicone material.
Silicone is thus used in the medical field such as treatment of wounds and keloids.
Further, with regard to chitosan, cosmetic techniques containing chitosan have been developed by paying attention to anti-allergic action, antibacterial action, moisturizing action, anti-inflammatory action, etc., which chitosan conventionally has (see, for example, Patent Document 1).

JP-A-2002-121109 ([0018])

However, an external preparation for skin that combines the pharmacological action of silicone and the anti-allergy pharmacological action of chitosan has not been developed yet.
Therefore, an object of the present invention is to provide an external preparation for skin mainly composed of silicone having both pharmacological action of silicone and pharmacological action of chitosan.

In order to achieve the above object, the external preparation for skin of the present invention comprises a silicone material or a solution using a silicone material and chitosan.
By blending a silicone material and chitosan, it is possible to provide a skin external preparation having a wound healing effect and a pharmacological effect of chitosan.
In addition, when a solution containing a silicone material as a main material is used, it can be applied to acne marks, marks that are retracted, such as spots and wrinkles, and dents.

The external preparation for skin mainly comprising silicone of the present invention comprises a silicone material or a solution mainly composed of a silicone material, chitosan, and a substance that promotes a negative electrostatic potential.
By blending with a substance that promotes a negative electrostatic potential, the wound healing effect can be further enhanced.

The solution containing the silicone material as a main material preferably has a water content of 15% or less, and most preferably 10% or less.
When the moisture content is about 15%, the topical skin preparation of the present invention evaporates in about 40 minutes when applied to the skin, can generate an electrostatic potential, and about 10% In this case, water evaporates in about 20 to 30 minutes, and an electrostatic potential is generated.
Moreover, it is preferable that the solution containing the silicone material as a main material is an alcohol liquid.

  Moreover, the wound healing effect of silicone can be further increased by blending a substance that promotes a negative electrostatic potential such as tourmaline, silicone powder or polyethylene powder.

Chitosan is refined from living organisms (crabs and shrimp shells), and does not cause rejection reactions in the human body. It is excellent in biocompatibility and is not regarded as a foreign body, so it can absorb surgical sutures, wounds and burns. Used for artificial skin and dressing for treatment. This is because it is absorbed in the body. Chitosan has such properties, and has anti-allergic action, antibacterial action, moisturizing action, anti-inflammatory action and the like as described above.
In addition, silicone is not a skin regrowth by just applying the wound, keloid, convulsion, firmness, color tone, pain, itch, etc. to the local area, but it can normalize. It has a moisturizing effect and normalization by removing local overstimulation due to the negative electrostatic potential of silicone.
By blending chitosan having such an action and silicone, an external preparation for skin having both actions can be provided.

Chitosan may be in the form of a powder or an aqueous solution, but the aqueous solution may contain a preservative, and since the preservative is not preferable for people with atopy, a powder that can be used as it is is preferable.
The silicone material is preferably in the form of oil, gel, cream or solution. Gels and creams only differ in viscosity.

  When the topical skin preparation of the present invention is applied to the affected area of the skin, the oil, gel, cream or solution is well suited to the affected area, so that the oil, gel, cream or solution The shape is preferred.

KSG-210 is a silicone material that has a hydrophilic group despite the fact that silicone has extremely high fat solubility, so even if it is mixed with chitosan, etc. It is very convenient for the cosmetic ingredients to come into contact with and permeate the skin gradually due to moisture and moisture coming from the skin after being applied to the skin.
KSG-710 is hydrophilic and has the property of quickly penetrating other water-soluble ingredients into the skin.
Since KSG-18 has no hydrophilic group, it can be blended with lipophilic components and has a relatively good touch.
Furthermore, KSG-210, KSG-710, and KSG-18 show higher electrostatic potential values than other silicone materials.
Below is a comparison of KSG-210, KSG-710, KSG-18 and other silicon materials.

  Moreover, it is suitable that the compounding rate of the solution which uses a silicone raw material or a silicone raw material as a main material is 70% or more.

Hereinafter, production examples and test examples of the present invention will be described.
(Production Example 1)
Weigh 20 g of chitosan, weigh 980 g of silicone KSG-210, put both components in a stainless steel container, attach a three-motor to a stainless steel stirrer, and stir and knead at 600 rpm. After stirring for about 30 minutes, the mixture became sufficiently uniform. After centrifuging for 30 minutes, the mixture was sucked with a 25 mL plastic syringe and filled in 8 to 10 g of polyethylene tubes. 100 were made.

(Test example)
Effect of silicone gel + chitosan on human effect Purpose of human atopy and scars with cream containing chitosan which is said to have moisturizing, anti-inflammatory and bactericidal action on silicone gel base material with wound scar repairing effect investigated.
Test drug Chitosan: Timely Co., Ltd. Silicone gel: KSG-210: Dimethicone, (Dimethicone / PEG-10) crosspolymer / (Dimethicone / PEG-15) cross Polymer (manufactured by Shin-Etsu Chemical)
Formulation: Tested with 1, 2, and 4% chitosan to make 2% practical concentration.

3． Examination of effects in humans Difference in effect depending on concentration Chitosan was prepared at 1%, 2%, and 4% with respect to KSG-210 and tested. As a reference, KSG-210 alone, commercially available chitosan cream (KK Beauty Cream Co., Ltd. manufactured by Chitosan Kowa) was prepared and compared.

We applied 5 types of prototypes to 39-year-old women diagnosed with atopy and compared their effects by observing them for one month. The first and first month of itching, redness, and scratches are evaluated on a 6-point scale (0: not recognized, 1: hardly recognized, 2: slightly recognized, 3: slightly recognized, 4: recognized, 5: equivalently recognized) And observed. The application was repeated three times in the morning, after noon, in the evening, and on the day before going to bed.

The results are shown below.

Findings: At 1 month, no change was seen in the untreated area, but it was found that KSG-210 alone relieved the symptoms overall. A similar effect was seen with commercial chitosan cream, but the scratch seemed not to change much. The results showed that the cream with 1% chitosan faded particularly quickly, and 2% and 4% had the same effect on soo sensation.
However, there seemed to be no significant difference in effectiveness between 2% and 4%. Although only the effect was seen in one month, the itch disappeared comprehensively in one month, and the scratches were reduced accordingly. With regard to redness, the improvement rate seems to be a little slow, but taking into account that wounds take time to heal and that skin regeneration is generally a 30-45 day cycle, It was thought that the effect was effective against the symptoms of

Four. Conclusion A cream containing silicone gel KSG-210 and chitosan was found to have a certain effect on improving symptoms such as atopy's soothing, redness and scratches. Regarding the concentration of chitosan, it is considered that about 2% is sufficient for this formulation with KSG-210.
The silicone gel KSG-210 used as a base material has a good touch to the skin and was developed as a surfactant for cosmetics, etc. can not see. The idea is that silicone cream is used for the repair of wounds by the action of moisturizing and electrostatic potential, so by adding chitosan, which is said to have moisturizing, anti-inflammatory and antibacterial effects, the action of both can be achieved. In addition, it has been found that it is useful as a coating agent for alleviating symptoms such as atopy.

Claims (7)

A skin external preparation comprising silicone as a main component, comprising a silicone material or a solution containing chitosan as a main ingredient and chitosan. A skin external preparation comprising silicone as a main component, comprising a silicone material or a solution mainly composed of a silicone material, chitosan, and a substance that promotes a negative electrostatic potential. 3. The skin external preparation comprising silicone as a main component according to claim 1 or 2, wherein the silicone material is oily, gel-like, or cream-like. The skin external preparation based on silicone according to claim 1 or 2, wherein the solution containing the silicone material as a main material is an aqueous solution or an emulsion having a water content of 15% or less. 3. The skin external preparation comprising silicone as a main component according to claim 1 or 2, wherein the solution mainly composed of the silicone material is an alcohol liquid. The gel-like silicone material is dimethicone, (dimethicone / PEG-10) cross polymer / (dimethicone / PEG-15) cross polymer, (dimethicone / polyglycerin-3 cross polymer) / dimethicone, or (dimethicone / phenyl dimethicone) cross. The skin external preparation based on silicone according to claim 3, which is a polymer / phenyltrimethicone gel. The skin external preparation containing silicone as a main component according to claim 2, wherein the substance that promotes the negative electrostatic potential is tourmaline, silicone powder or polyethylene powder.