JP2004530114A5 - - Google Patents

Info

Publication number

JP2004530114A5

JP2004530114A5 JP2002566656A JP2002566656A JP2004530114A5 JP 2004530114 A5 JP2004530114 A5 JP 2004530114A5 JP 2002566656 A JP2002566656 A JP 2002566656A JP 2002566656 A JP2002566656 A JP 2002566656A JP 2004530114 A5 JP2004530114 A5 JP 2004530114A5

Authority

JP

Japan

Prior art keywords

sepcr

measured

patient

levels

immunoassay

Prior art date

2002-02-19

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Withdrawn

Links

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• 238000000034 method Methods 0.000 claims 33
• 239000003146 anticoagulant agent Substances 0.000 claims 12
• 229940127219 anticoagulant drug Drugs 0.000 claims 10
• 239000010836 blood and blood product Substances 0.000 claims 8
• 229940125691 blood product Drugs 0.000 claims 8
• 238000002965 ELISA Methods 0.000 claims 5
• 238000003018 immunoassay Methods 0.000 claims 5
• 201000005665 thrombophilia Diseases 0.000 claims 5
• 210000001175 cerebrospinal fluid Anatomy 0.000 claims 4
• WQPDUTSPKFMPDP-OUMQNGNKSA-N hirudin Chemical compound C([C@@H](C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC=1C=CC(OS(O)(=O)=O)=CC=1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(O)=O)NC(=O)[C@H](CC(O)=O)NC(=O)CNC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC=1NC=NC=1)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H]1N(CCC1)C(=O)[C@H](CCCCN)NC(=O)[C@H]1N(CCC1)C(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)CNC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H]1NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(O)=O)NC(=O)CNC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H]([C@@H](C)CC)NC(=O)[C@@H]2CSSC[C@@H](C(=O)N[C@@H](CCC(O)=O)C(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@H](C(=O)N[C@H](C(NCC(=O)N[C@@H](CCC(N)=O)C(=O)NCC(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCCN)C(=O)N2)=O)CSSC1)C(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H]1NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)CNC(=O)[C@H](CO)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CC=2C=CC(O)=CC=2)NC(=O)[C@@H](NC(=O)[C@@H](N)C(C)C)C(C)C)[C@@H](C)O)CSSC1)C(C)C)[C@@H](C)O)[C@@H](C)O)C1=CC=CC=C1 WQPDUTSPKFMPDP-OUMQNGNKSA-N 0.000 claims 4
• 230000037361 pathway Effects 0.000 claims 4
• 210000002966 serum Anatomy 0.000 claims 4
• 210000002700 urine Anatomy 0.000 claims 4
• PJVWKTKQMONHTI-UHFFFAOYSA-N warfarin Chemical compound OC=1C2=CC=CC=C2OC(=O)C=1C(CC(=O)C)C1=CC=CC=C1 PJVWKTKQMONHTI-UHFFFAOYSA-N 0.000 claims 4
• 102000009839 Endothelial Protein C Receptor Human genes 0.000 claims 3
• 108010009900 Endothelial Protein C Receptor Proteins 0.000 claims 3
• 238000002560 therapeutic procedure Methods 0.000 claims 3
• 108010039209 Blood Coagulation Factors Proteins 0.000 claims 2
• 102000015081 Blood Coagulation Factors Human genes 0.000 claims 2
• HTTJABKRGRZYRN-UHFFFAOYSA-N Heparin Chemical compound OC1C(NC(=O)C)C(O)OC(COS(O)(=O)=O)C1OC1C(OS(O)(=O)=O)C(O)C(OC2C(C(OS(O)(=O)=O)C(OC3C(C(O)C(O)C(O3)C(O)=O)OS(O)(=O)=O)C(CO)O2)NS(O)(=O)=O)C(C(O)=O)O1 HTTJABKRGRZYRN-UHFFFAOYSA-N 0.000 claims 2
• 102000007625 Hirudins Human genes 0.000 claims 2
• 108010007267 Hirudins Proteins 0.000 claims 2
• 101800004937 Protein C Proteins 0.000 claims 2
• 102000017975 Protein C Human genes 0.000 claims 2
• 101800001700 Saposin-D Proteins 0.000 claims 2
• 108090000190 Thrombin Proteins 0.000 claims 2
• 102100030951 Tissue factor pathway inhibitor Human genes 0.000 claims 2
• 230000000702 anti-platelet effect Effects 0.000 claims 2
• 239000003698 antivitamin K Substances 0.000 claims 2
• 239000003114 blood coagulation factor Substances 0.000 claims 2
• 150000001875 compounds Chemical class 0.000 claims 2
• 229940072645 coumadin Drugs 0.000 claims 2
• 230000020764 fibrinolysis Effects 0.000 claims 2
• 229960005298 fluindione Drugs 0.000 claims 2
• NASXCEITKQITLD-UHFFFAOYSA-N fluindione Chemical compound C1=CC(F)=CC=C1C1C(=O)C2=CC=CC=C2C1=O NASXCEITKQITLD-UHFFFAOYSA-N 0.000 claims 2
• 229960002897 heparin Drugs 0.000 claims 2
• 229920000669 heparin Polymers 0.000 claims 2
• 229940006607 hirudin Drugs 0.000 claims 2
• 239000003112 inhibitor Substances 0.000 claims 2
• 108010013555 lipoprotein-associated coagulation inhibitor Proteins 0.000 claims 2
• 239000003055 low molecular weight heparin Substances 0.000 claims 2
• 229940127215 low-molecular weight heparin Drugs 0.000 claims 2
• 238000012544 monitoring process Methods 0.000 claims 2
• -1 pentasaccharide Chemical compound 0.000 claims 2
• 229960000856 protein c Drugs 0.000 claims 2
• 229960004072 thrombin Drugs 0.000 claims 2
• 229940019333 vitamin k antagonists Drugs 0.000 claims 2
• 229960005080 warfarin Drugs 0.000 claims 2
• 201000001320 Atherosclerosis Diseases 0.000 claims 1
• 208000023275 Autoimmune disease Diseases 0.000 claims 1
• 206010028980 Neoplasm Diseases 0.000 claims 1
• 206010040047 Sepsis Diseases 0.000 claims 1
• 201000011510 cancer Diseases 0.000 claims 1
• 206010012601 diabetes mellitus Diseases 0.000 claims 1
• 230000000694 effects Effects 0.000 claims 1
• 208000019622 heart disease Diseases 0.000 claims 1