JP2004501985A5 - - Google Patents
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- Publication number
- JP2004501985A5 JP2004501985A5 JP2002509335A JP2002509335A JP2004501985A5 JP 2004501985 A5 JP2004501985 A5 JP 2004501985A5 JP 2002509335 A JP2002509335 A JP 2002509335A JP 2002509335 A JP2002509335 A JP 2002509335A JP 2004501985 A5 JP2004501985 A5 JP 2004501985A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- aryl
- group
- aralkyl
- disease
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 125000000217 alkyl group Chemical group 0.000 claims description 58
- 125000003118 aryl group Chemical group 0.000 claims description 44
- 125000003710 aryl alkyl group Chemical group 0.000 claims description 24
- -1 R ′′ is H Chemical group 0.000 claims description 23
- 238000000034 method Methods 0.000 claims description 22
- 125000002252 acyl group Chemical group 0.000 claims description 20
- 125000003342 alkenyl group Chemical group 0.000 claims description 20
- 125000000304 alkynyl group Chemical group 0.000 claims description 20
- 125000001072 heteroaryl group Chemical group 0.000 claims description 20
- 125000004093 cyano group Chemical group *C#N 0.000 claims description 18
- 210000001744 T-lymphocyte Anatomy 0.000 claims description 17
- 150000001875 compounds Chemical class 0.000 claims description 17
- 201000010099 disease Diseases 0.000 claims description 16
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 16
- 125000004475 heteroaralkyl group Chemical group 0.000 claims description 16
- 210000004027 cell Anatomy 0.000 claims description 10
- 230000001404 mediated effect Effects 0.000 claims description 9
- 238000013508 migration Methods 0.000 claims description 9
- 230000005012 migration Effects 0.000 claims description 9
- 150000001720 carbohydrates Chemical class 0.000 claims description 8
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 8
- 239000000651 prodrug Substances 0.000 claims description 8
- 229940002612 prodrug Drugs 0.000 claims description 8
- 150000003839 salts Chemical class 0.000 claims description 8
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims description 6
- 125000004204 2-methoxyphenyl group Chemical group [H]C1=C([H])C(*)=C(OC([H])([H])[H])C([H])=C1[H] 0.000 claims description 4
- 125000004105 2-pyridyl group Chemical group N1=C([*])C([H])=C([H])C([H])=C1[H] 0.000 claims description 4
- 125000003349 3-pyridyl group Chemical group N1=C([H])C([*])=C([H])C([H])=C1[H] 0.000 claims description 4
- 125000004172 4-methoxyphenyl group Chemical group [H]C1=C([H])C(OC([H])([H])[H])=C([H])C([H])=C1* 0.000 claims description 4
- 125000000339 4-pyridyl group Chemical group N1=C([H])C([H])=C([*])C([H])=C1[H] 0.000 claims description 4
- 208000011231 Crohn disease Diseases 0.000 claims description 4
- 201000004624 Dermatitis Diseases 0.000 claims description 4
- 206010023335 Keratitis interstitial Diseases 0.000 claims description 4
- 201000004681 Psoriasis Diseases 0.000 claims description 4
- 206010046851 Uveitis Diseases 0.000 claims description 4
- 208000002552 acute disseminated encephalomyelitis Diseases 0.000 claims description 4
- 125000004183 alkoxy alkyl group Chemical group 0.000 claims description 4
- 125000003545 alkoxy group Chemical group 0.000 claims description 4
- 125000004103 aminoalkyl group Chemical group 0.000 claims description 4
- 125000005160 aryl oxy alkyl group Chemical group 0.000 claims description 4
- 125000005842 heteroatom Chemical group 0.000 claims description 4
- 125000002768 hydroxyalkyl group Chemical group 0.000 claims description 4
- 208000027866 inflammatory disease Diseases 0.000 claims description 4
- 201000006904 interstitial keratitis Diseases 0.000 claims description 4
- JIQNWFBLYKVZFY-UHFFFAOYSA-N methoxycyclohexatriene Chemical compound COC1=C[C]=CC=C1 JIQNWFBLYKVZFY-UHFFFAOYSA-N 0.000 claims description 4
- 201000006417 multiple sclerosis Diseases 0.000 claims description 4
- 125000000286 phenylethyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])* 0.000 claims description 4
- 125000000246 pyrimidin-2-yl group Chemical group [H]C1=NC(*)=NC([H])=C1[H] 0.000 claims description 4
- 125000004527 pyrimidin-4-yl group Chemical group N1=CN=C(C=C1)* 0.000 claims description 4
- 125000004528 pyrimidin-5-yl group Chemical group N1=CN=CC(=C1)* 0.000 claims description 4
- 206010039073 rheumatoid arthritis Diseases 0.000 claims description 4
- 208000024891 symptom Diseases 0.000 claims description 4
- 206010043778 thyroiditis Diseases 0.000 claims description 4
- 125000000040 m-tolyl group Chemical group [H]C1=C([H])C(*)=C([H])C(=C1[H])C([H])([H])[H] 0.000 claims description 3
- 125000001037 p-tolyl group Chemical group [H]C1=C([H])C(=C([H])C([H])=C1*)C([H])([H])[H] 0.000 claims description 3
- 239000003085 diluting agent Substances 0.000 claims description 2
- 239000003814 drug Substances 0.000 claims description 2
- 239000003937 drug carrier Substances 0.000 claims description 2
- 238000004519 manufacturing process Methods 0.000 claims description 2
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 2
- 239000000203 mixture Substances 0.000 claims description 2
- 125000003261 o-tolyl group Chemical group [H]C1=C([H])C(*)=C(C([H])=C1[H])C([H])([H])[H] 0.000 claims description 2
- 239000000546 pharmaceutical excipient Substances 0.000 claims description 2
- 125000006367 bivalent amino carbonyl group Chemical group [H]N([*:1])C([*:2])=O 0.000 claims 2
- 125000006297 carbonyl amino group Chemical group [H]N([*:2])C([*:1])=O 0.000 claims 2
- 208000001072 type 2 diabetes mellitus Diseases 0.000 claims 2
- 239000000126 substance Substances 0.000 description 7
- 125000000094 2-phenylethyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])* 0.000 description 4
- 241001465754 Metazoa Species 0.000 description 4
- 238000009825 accumulation Methods 0.000 description 4
- 235000014633 carbohydrates Nutrition 0.000 description 4
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 description 4
- 210000001519 tissue Anatomy 0.000 description 4
- 102000004169 proteins and genes Human genes 0.000 description 3
- 108090000623 proteins and genes Proteins 0.000 description 3
- 229910018828 PO3H2 Inorganic materials 0.000 description 2
- 206010067584 Type 1 diabetes mellitus Diseases 0.000 description 2
- 238000002474 experimental method Methods 0.000 description 2
- IIEWJVIFRVWJOD-UHFFFAOYSA-N CCC1CCCCC1 Chemical compound CCC1CCCCC1 IIEWJVIFRVWJOD-UHFFFAOYSA-N 0.000 description 1
- 206010070834 Sensitisation Diseases 0.000 description 1
- 206010053613 Type IV hypersensitivity reaction Diseases 0.000 description 1
- 229940100198 alkylating agent Drugs 0.000 description 1
- 239000002168 alkylating agent Substances 0.000 description 1
- 210000003719 b-lymphocyte Anatomy 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 210000000987 immune system Anatomy 0.000 description 1
- 238000010253 intravenous injection Methods 0.000 description 1
- 230000008313 sensitization Effects 0.000 description 1
- 210000000952 spleen Anatomy 0.000 description 1
- 125000001425 triazolyl group Chemical group 0.000 description 1
- 208000027930 type IV hypersensitivity disease Diseases 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AUPQ8723A AUPQ872300A0 (en) | 2000-07-11 | 2000-07-11 | Compounds and methods |
| AUPQ8723 | 2000-07-11 | ||
| PCT/AU2001/000831 WO2002004472A1 (en) | 2000-07-11 | 2001-07-11 | Novel compounds and methods |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2004501985A JP2004501985A (ja) | 2004-01-22 |
| JP2004501985A5 true JP2004501985A5 (enExample) | 2008-09-04 |
| JP5035940B2 JP5035940B2 (ja) | 2012-09-26 |
Family
ID=3822788
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2002509335A Expired - Fee Related JP5035940B2 (ja) | 2000-07-11 | 2001-07-11 | 新規化合物および方法 |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US6878690B2 (enExample) |
| EP (1) | EP1301522A4 (enExample) |
| JP (1) | JP5035940B2 (enExample) |
| AU (1) | AUPQ872300A0 (enExample) |
| CA (1) | CA2415214C (enExample) |
| NZ (1) | NZ523565A (enExample) |
| WO (1) | WO2002004472A1 (enExample) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK1628987T3 (da) * | 2003-05-20 | 2009-12-21 | Pharmaxis Pty Ltd | Mannose-6-phosphonat-forbindelser til behandling af inflammatoriske sygdomme |
| AU2004256124B2 (en) * | 2003-07-02 | 2011-04-28 | Corus Pharma, Inc. | Aztreonam L-lysine and methods for the preparation thereof |
| US20080057072A1 (en) * | 2006-08-31 | 2008-03-06 | Alcon Manufacturing, Ltd. | Antagonists of ci-m6p/igf2r for prevention and treatment of ctgf-mediated ocular disorders |
| NZ596419A (en) * | 2009-04-28 | 2014-01-31 | Pharmaxis Ltd | Phosphotetrahydropyran compounds for the treatment of wounds and fibrotic disorders |
| FR2992647B1 (fr) * | 2012-07-02 | 2016-04-01 | Centre Nat Rech Scient | Derives de glycosides, leur preparation et leur utilisation comme groupes prosthetiques |
| KR102075885B1 (ko) | 2012-12-18 | 2020-02-11 | 버텍스 파마슈티칼스 인코포레이티드 | 세균 감염 치료용 만노스 유도체 |
| US9890176B2 (en) | 2013-03-12 | 2018-02-13 | Vertex Pharmaceuticals Incorporated | Mannose derivatives for treating bacterial infections |
| JP6670019B2 (ja) * | 2015-03-24 | 2020-03-18 | 学校法人沖縄科学技術大学院大学学園 | Ｃ−グリコシド誘導体 |
| EP3959220A1 (en) * | 2019-04-26 | 2022-03-02 | Shanghai Yao Yuan Biotechnology Co., Ltd. | Derivatives of glycero-manno-heptose phosphate and their use in modulating an immune response |
| CN112315950A (zh) * | 2020-12-25 | 2021-02-05 | 西北农林科技大学 | 苯丙氨酸在制备防治葛根素注射剂诱发的血管内溶血的药物上的应用 |
| CN113563136A (zh) * | 2021-07-01 | 2021-10-29 | 胡国府 | 一种可溶性固态缓释肥料剂及其施用方法 |
| CN116272899B (zh) * | 2023-03-01 | 2025-04-04 | 西安理工大学 | 一种鳞片状中空纤维气凝胶的制备方法 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5506210A (en) | 1988-08-19 | 1996-04-09 | The Australian National University | Phosphosugar-based anti-inflammatory and/or immunosuppressive drugs |
| GB9516012D0 (en) * | 1995-08-04 | 1995-10-04 | Univ Manchester | Pharmaceutical composition |
| AUPO309896A0 (en) | 1996-10-18 | 1996-11-14 | Australian National University, The | Novel phosphosugars and phosphosugar-containing compounds having anti-inflammatory activity |
| GB9626450D0 (en) * | 1996-12-20 | 1997-02-05 | Oxford Glycosciences Uk Ltd | Therapeutic compounds |
-
2000
- 2000-07-11 AU AUPQ8723A patent/AUPQ872300A0/en not_active Abandoned
-
2001
- 2001-07-11 CA CA002415214A patent/CA2415214C/en not_active Expired - Fee Related
- 2001-07-11 WO PCT/AU2001/000831 patent/WO2002004472A1/en not_active Ceased
- 2001-07-11 JP JP2002509335A patent/JP5035940B2/ja not_active Expired - Fee Related
- 2001-07-11 EP EP01949109A patent/EP1301522A4/en not_active Withdrawn
- 2001-07-11 NZ NZ523565A patent/NZ523565A/en not_active IP Right Cessation
-
2003
- 2003-01-09 US US10/338,679 patent/US6878690B2/en not_active Expired - Fee Related
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