JP2004307513A - Composition for preparing carbon dioxide preparation for external use - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To provide a composition for preparing a carbon dioxide preparation for external use which can easily prepar an carbon dioxide preparation for external use in a short time without soiling clothes or the like and by which both enhanced beautification and a medical effect can be obtained in a short period of time. <P>SOLUTION: This composition for preparing the carbon dioxide preparation for external use comprises: a particulate material which contains a water-soluble acid, a thickener and a water-soluble dispersant as essential components, in which the thickener is blended with the water-soluble acid and the water-soluble dispersant in a specified blending ratio; and a viscous composition which contains a carbonate, water and a thickener as essential components, and blended with the particulate material in a specified ratio when used. The thickener and the water-soluble dispersant in the particulate material are prepared by a specified combination. When in use of the composition, the particulate material and the viscous material are blended in a specified ratio to be applied. <P>COPYRIGHT: (C)2005,JPO&NCIPI

Description

  The present invention relates to a composition used for preparing a carbon dioxide external preparation having a cosmetic effect and a medical effect.

  Percutaneous transmucosal absorption of carbon dioxide promotes blood circulation in the skin, subcutaneous tissues, and muscles, and activates metabolism to achieve cosmetic and medical effects. It is clear from various studies that carbonated springs are used in various places. For example, as a medical effect, Hiyoshi et al. Report that an artificial carbonated spring is effective for intractable pressure sores as an application to treatment of bedsores (for example, see Non-Patent Document 1).

  In order to easily obtain a cosmetic and medical effect by external use of carbon dioxide, an external agent for carbon dioxide containing carbon dioxide and an external agent for generating carbon dioxide by preparation at the time of use have been proposed. External preparations for carbon dioxide have problems such as the lack of established production technology and the high cost of storage containers with no or low loss of carbon dioxide. These problems are lessened in external preparations that generate, and are more practical. As a composition from which such an external preparation can be prepared, for example, Patent Document 1 proposes a composition production kit for carbon dioxide transdermal / transmucosal absorption. In this publication, the percutaneous and transmucosal absorption of carbon dioxide is athlete's foot, insect bite, atopic dermatitis, monetary eczema, xerosis, seborrheic eczema, hives, prurigo, housewife eczema, vulgaris Acne, impetigo, folliculitis, bunching, swelling, cellulitis, pyoderma, psoriasis, ichthyosis, palmar keratosis, lichen, pityriasis, wound, burn, crack, erosion, frost acne Skin mucosal diseases such as pruritus, pressure sores, wounds, burns, stomatitis, stomatitis, skin ulcers, cracks, erosions, frost acne, gangrene, etc .; skin grafts, flaps, etc. Dental diseases such as gingivitis, alveolar pyorrhea, denture ulcer, melanized gingiva, stomatitis; peripheral circulation such as obstructive thromboangitis, obstructive arteriosclerosis, diabetic peripheral circulatory dysfunction, varicose veins Skin ulcers, cold sensation, numbness due to disability; rheumatoid arthritis, neck and shoulder arm syndrome, muscle pain, joint pain, lower back Musculoskeletal diseases such as sclerosis; nervous system diseases such as neuralgia, polyneuritis, and Smon's disease; dyskeratosis such as psoriasis, chicken eyes, octopus, ichthyosis, palmoplantar keratosis, lichen, pityriasis ; Purulent skin diseases such as acne vulgaris, impetigo, folliculitis, bunches, scabs, cellulitis, pyoderma, purulent eczema; suppression of recurrent hair after hair removal (waste hair treatment); freckles It is disclosed that it is effective for cosmetic problems such as skin and hair and partial obesity such as rough skin, dullness of the skin, weakness of the skin, weakening of the gloss of the skin, and weakening of the gloss of the hair.

Toshiki Hiyoshi; Treatment of pressure sores with artificial carbonated spring bath. General Rehabilitation 17 (8): 605-609, 1989 JP 2000-319187 A

  The kit is a combination of a basic composition containing water, a thickener and a carbonate, and a carbon dioxide generation auxiliary containing an acid, or an acidic composition containing water, a thickener and an acid, It consists of a combination with a carbon dioxide generating auxiliary containing salt, and mixes each composition and the corresponding carbon dioxide generating auxiliary at the time of use to generate carbon dioxide, thereby preparing a carbon dioxide external preparation. In order to easily and surely mix the acid and carbonate preparations and thus generate carbon dioxide, the viscosity of the acidic composition or the basic composition cannot be too high. Therefore, when a carbon dioxide external preparation is prepared using the kit, the viscosity is insufficient, and when applied to a vertical portion, the external preparation drips, and supply of carbon dioxide to the applied part is not possible. It is not only completely or impossible but also has the drawback of soiling clothes. In addition, in the application to the lying portion, the thickness of the external preparation is not sufficiently ensured by the weight of the external preparation, so that the amount of supplied carbon dioxide becomes insufficient, and a sufficient cosmetic or medical effect is obtained. There were drawbacks such as no. When the viscosity of an acidic composition or a basic composition is increased in order to secure the necessary viscosity of a carbon dioxide external preparation, there is a drawback that mixing and dissolving these with a corresponding carbon dioxide generation auxiliary becomes difficult. . In addition, even if the two are forcedly mixed, carbon dioxide is not sufficiently generated due to insufficient dissolution of the carbon dioxide generation auxiliary, or even if it is generated, it takes time to mix and dissolve the carbon dioxide generation auxiliary. In addition, there is a drawback in that carbon dioxide diverges into the outside air on the way and a carbon dioxide external preparation containing a sufficient concentration of carbon dioxide cannot be prepared.

  For this reason, the carbon dioxide transdermal / transmucosal composition-production kit must use only an acidic composition or a basic composition having a relatively low viscosity. Therefore, the external preparation for carbon dioxide prepared from the kit is difficult to use when applied to the skin and mucous membranes, because it sags or the thickness cannot be ensured. In addition, since sufficient carbon dioxide is not supplied to the skin and mucous membranes, it is necessary to frequently use the carbon dioxide external preparation to obtain a desired effect. For example, face thinning using the carbon dioxide external preparation requires two weeks to two months of daily use.

  In general, thickeners have a slow swelling rate and dissolution rate in water when they come in contact with water, so if they are mixed with water as they are, the thickeners that are solids agglomerate, and solids that do not contain water It is easy to become a so-called "dama" or "mamako" which is an agglomerate surrounded by a viscous material that has been dissolved or swollen on the outside. Since it is difficult for water to penetrate into the inside of the "dama" or "mamako" due to the viscous material, it takes time to obtain a desired viscosity when making a viscous composition. Pharmaceutical formulations that promote the dissolution or swelling of the thickener are also known, but there is no known composition for preparing a carbon dioxide external preparation that can easily obtain a high-viscosity carbon dioxide external preparation in a short time. Had not been.

  It is an object of the present invention to provide a carbon dioxide external preparation that can be easily prepared in a short time, does not stain clothes and the like, and provides a stronger cosmetic and medical effect in a shorter time. To obtain a composition for preparing an agent.

The composition for preparing a carbon dioxide external preparation of the present invention has a water-soluble acid, a thickener, and a water-soluble dispersant as essential components, and a granular material in which the thickener is mixed with a water-soluble acid and a water-soluble dispersant. , A carbonate, water, and a thickener as essential components, and a viscous composition to be mixed with the granules at the time of use.
The water-soluble dispersant referred to in the present invention, itself is easily dissolved in water, and when mixed with a particulate thickener, the particles are stably dispersed in the dispersant, and the particles are separated from each other. Refers to all substances. Note that a water-soluble acid also functions as a water-soluble dispersant. Further, the granular material as used in the present invention means a solid preparation in which raw materials are mixed and processed into granules such as granules, fine granules, and microcapsules. Furthermore, the external preparation for carbon dioxide referred to in the present invention is intended to be applied to the skin and mucous membranes to absorb carbon dioxide transdermally and transmucosally, and to use an external preparation containing carbon dioxide in the composition. means.
In the composition for preparing an external carbon dioxide agent of the present invention, the viscous composition has such a viscosity that it can easily mix and disintegrate particulate matter. The thickener is in the form of particles, and in the granular material in which the thickener is mixed with a water-soluble acid and a water-soluble dispersant, the particles of the thickener are separated from each other by the water-soluble acid and the water-soluble dispersant. . Further, since the thickener is in the form of particles and has a large total surface area, when mixed with the viscous composition, the thickener dissolves or swells in a short time with water in the viscous composition. At this time, since the thickener particles are separated from each other, the thickener particles do not dissolve or swell before agglomeration, and there is no risk of "dama" or "mamako". Further, even if the initial viscosity of the viscous composition is not so high, a carbon dioxide external preparation having a sufficient viscosity can be obtained in a short time. As a result, it is possible to easily prepare a carbon dioxide external preparation in which carbon dioxide generated by the reaction between the water-soluble acid and the carbonate hardly escapes into the outside air in a short time. Moreover, when the external preparation is applied to the skin and mucous membranes, it has an appropriate adhesive strength, adheres to the skin and mucous membranes, and is hard to sag in the vertical part, and the thickness of the external preparation by its own weight in the horizontal part. Since the decrease is small, it is difficult to stain clothes, etc., and it is possible to supply a sufficient amount of carbon dioxide to the application site, the beauty and medical effect of carbon dioxide is stronger than the conventional technology, and the beauty and medical effect is shorter can get.

In one preferred embodiment, the composition for preparing a carbon dioxide external preparation comprises 2 to 50% by weight of a water-soluble acid, 10 to 40% by weight of a thickener, and 30 to 30% by weight of a whole granule. To 85% by weight, 0.1 to 10% by weight of carbonate, 70 to 97.5% by weight of water, 0.5 to 20% by weight of thickener based on the whole viscous composition, Weight ratio of the substance and the viscous composition is 1:10 to 40. In this embodiment, the granules are dispersed and disintegrated in the viscous composition in a short time, and the thickener in the granules is rapidly dissolved or swelled to increase the viscosity of the viscous composition in a short time. When the acid and the carbonate react at an appropriate rate to generate a necessary and sufficient amount of carbon dioxide evenly in the mixture of the viscous composition and the granular material, and when applied to the skin and mucous membranes without being released into the outside air. An external preparation for carbon dioxide in which carbon dioxide can be absorbed transdermally and transmucosally efficiently can be prepared. Further, since the external preparation for carbon dioxide obtained by this embodiment has sufficient viscosity, it does not sag at all even when applied to a vertical portion. In addition, since it has appropriate flexibility and spreadability, it follows the expansion and contraction of the application site. For this reason, it is possible to move while applying. Furthermore, even if it is applied to the lying part, there is no reduction in thickness or application area due to its own weight, and it is possible to administer the necessary and sufficient amount of carbon dioxide only to the desired site precisely, Strong beauty and medical effects can be obtained.
In another preferred embodiment, in the composition for preparing a carbon dioxide external preparation, the viscous composition contains 1 to 15% by weight of a polyhydric alcohol. The carbon dioxide external preparation obtained from the carbon dioxide external preparation preparation composition of the present invention has good usability as it is, but the viscous composition contains a polyhydric alcohol, so that the carbon dioxide external preparation is prepared. Since the adhesiveness to the skin and the mucous membrane and the extension are further improved, the effect is more reliably obtained and the usability is further improved.

In the composition for preparing a carbon dioxide external preparation, the water-soluble acid is preferably at least one selected from the group consisting of citric acid, malic acid, tartaric acid, and sodium dihydrogen phosphate. All of the above-mentioned acids are widely used as food additives and the like, have relatively chemical stability, are easily dissolved in water, and react with carbonates to generate carbon dioxide efficiently.
In the composition for preparing a carbon dioxide external preparation, the water-soluble acid is more preferably malic acid. Since citric acid and sodium dihydrogen phosphate are hygroscopic and sticky, there are some problems in the production efficiency of granules and measures against moisture during storage, and tartaric acid is hardly soluble in low-temperature water. Although malic acid, especially DL-malic acid, is extremely soluble in water, it has no hygroscopicity, so the production efficiency of granules is high, the storage stability is excellent, and it is soluble in viscous compositions. Therefore, it is easy to prepare a carbon dioxide external preparation.
In the composition for preparing a carbon dioxide external preparation, the granular thickener is preferably at least one selected from the group consisting of processed starch, dextrin, xanthan gum, hydroxypropylcellulose, and polyvinylpyrrolidone. In this case, the dissolution of the thickener in water is relatively quick, and the feeling of use is good.
In the composition for preparing a carbon dioxide external preparation, the thickener of the viscous composition is preferably at least one selected from the group consisting of sodium alginate, propylene glycol alginate, and sodium carboxymethylcellulose (CMC-Na). Since sodium alginate has a strong protein binding property, it is used as a mucosa protective agent and a wound protective agent in medical applications, and can treat rough skin and wounds. Therefore, it is suitably used for cosmetic or medical purposes which is the object of the present invention. Is done. In addition, sodium alginate has a property of increasing viscosity due to acidity, and when a carbon dioxide external preparation prepared by mixing with granules becomes acidic, it is additive or synergistic to the effect of adding a thickener by the granules. In order to increase the viscosity by acting on the composition, it is easy to mix and dissolve the particulate matter into the viscous composition, but the obtained carbon dioxide external preparation has a sufficient viscosity. In addition, propylene glycol alginate has a small change in viscosity due to a change in the hydrogen ion index, so that it is easy to adjust the viscosity when used in a viscous composition and has good elongation, so that it is easy to apply and excellent in use feeling. In addition, sodium carboxymethylcellulose provides strong adhesiveness in a small amount and promotes close contact of the external preparation for carbon dioxide with the skin and mucous membranes, so that transdermal and transmucosal absorption of carbon dioxide becomes more reliable and a film is easily formed. Therefore, the portion of the external preparation that comes into contact with air suppresses the emission of carbon dioxide by the coating, thereby increasing the utilization rate of carbon dioxide for transdermal and transmucosal absorption. Due to the effect of these thickeners alone, the carbon dioxide external preparation prepared from the composition for preparing a carbon dioxide external preparation of the present invention exhibits strong cosmetic and medical effects in a short time, but the complex by the combination of these thickeners With the effect, a stronger cosmetic and medical effect can be obtained in a shorter time.
In the composition for preparing an external preparation for carbon dioxide, the water-soluble dispersant for the granular substance is at least one selected from the group consisting of xylitol, D-sorbitol, glucose, D-mannitol, fructose, sucrose, lactose, sucrose, and urea. Preferably, there is. All of the water-soluble dispersants are easily soluble in water, and by mixing the granular material and the viscous composition, a carbon dioxide external preparation having a sufficient viscosity can be easily prepared in a short time, and a stronger cosmetic and medical effect can be obtained. Obtained in a short time.

  The composition for preparing an external preparation for carbon dioxide of the present invention comprises a water-soluble acid, a thickener, and a water-soluble dispersant, which is another substance different from the thickener, as essential components, and the thickener comprises a water-soluble acid and a water-soluble agent. A granular material mixed with an aqueous dispersant, and a viscous composition containing carbonate, water, and a thickener as essential components and mixed with the granular material at the time of use, and a water-soluble acid for the entire granular material. Is 2 to 50% by weight, the thickener is 10 to 40% by weight, the water-soluble dispersant is 30 to 85% by weight, the carbonate is 0.1 to 10% by weight, Is 70 to 97.5% by weight, the thickener is 0.5 to 20% by weight, the weight ratio of the granular material to the viscous composition is 1:10 to 40, and the thickener for the granular material is Are processed starch, dextrin and potato starch, and the water-soluble dispersant of the granular material is lactose. That.

  The composition for preparing an external preparation for carbon dioxide of the present invention comprises a water-soluble acid, a thickener, and a water-soluble dispersant, which is another substance different from the thickener, as essential components, and the thickener comprises a water-soluble acid and a water-soluble agent. A granular material mixed with an aqueous dispersant, and a viscous composition containing carbonate, water, and a thickener as essential components and mixed with the granular material at the time of use, and a water-soluble acid for the entire granular material. Is 2 to 50% by weight, the thickener is 10 to 40% by weight, the water-soluble dispersant is 30 to 85% by weight, the carbonate is 0.1 to 10% by weight, Is 70 to 97.5% by weight, the thickener is 0.5 to 20% by weight, the weight ratio of the granular material to the viscous composition is 1:10 to 40, and the thickener for the granular material is Are dextrin and corn starch, and the water-soluble dispersant of the granular material is xylitol. It can be.

  The composition for preparing an external preparation for carbon dioxide of the present invention comprises a water-soluble acid, a thickener, and a water-soluble dispersant, which is another substance different from the thickener, as essential components, and the thickener comprises a water-soluble acid and a water-soluble agent. A granular material mixed with an aqueous dispersant, and a viscous composition containing carbonate, water, and a thickener as essential components and mixed with the granular material at the time of use, and a water-soluble acid for the entire granular material. Is 2 to 50% by weight, the thickener is 10 to 40% by weight, the water-soluble dispersant is 30 to 85% by weight, the carbonate is 0.1 to 10% by weight, Is 70 to 97.5% by weight, the thickener is 0.5 to 20% by weight, the weight ratio of the granular material to the viscous composition is 1:10 to 40, and the thickener for the granular material is Are dextrin and potato starch, and the granular water-soluble dispersant is lactose.

  The composition for preparing an external preparation for carbon dioxide of the present invention comprises a water-soluble acid, a thickener, and a water-soluble dispersant, which is another substance different from the thickener, as essential components, and the thickener comprises a water-soluble acid and a water-soluble agent. A granular material mixed with an aqueous dispersant, and a viscous composition containing carbonate, water, and a thickener as essential components and mixed with the granular material at the time of use, and a water-soluble acid for the entire granular material. Is 2 to 50% by weight, the thickener is 10 to 40% by weight, the water-soluble dispersant is 30 to 85% by weight, the carbonate is 0.1 to 10% by weight, Is 70 to 97.5% by weight, the thickener is 0.5 to 20% by weight, the weight ratio of the granular material to the viscous composition is 1:10 to 40, and the thickener for the granular material is Are dextrin and potato starch, and the water-soluble dispersant of the granular material is sucrose.

  The composition for preparing an external preparation for carbon dioxide of the present invention comprises a water-soluble acid, a thickener, and a water-soluble dispersant, which is another substance different from the thickener, as essential components, and the thickener comprises a water-soluble acid and a water-soluble agent. A granular material mixed with an aqueous dispersant, and a viscous composition containing carbonate, water, and a thickener as essential components and mixed with the granular material at the time of use, and a water-soluble acid for the entire granular material. Is 2 to 50% by weight, the thickener is 10 to 40% by weight, the water-soluble dispersant is 30 to 85% by weight, the carbonate is 0.1 to 10% by weight, Is 70 to 97.5% by weight, the thickener is 0.5 to 20% by weight, the weight ratio of the granular material to the viscous composition is 1:10 to 40, and the thickener for the granular material is However, the granular starch may be a processed starch, and the water-soluble dispersant of the granular material may be lactose.

  The composition for preparing an external preparation for carbon dioxide of the present invention comprises a water-soluble acid, a thickener, and a water-soluble dispersant, which is another substance different from the thickener, as essential components, and the thickener comprises a water-soluble acid and a water-soluble agent. A granular material mixed with an aqueous dispersant, and a viscous composition containing carbonate, water, and a thickener as essential components and mixed with the granular material at the time of use, and a water-soluble acid for the entire granular material. Is 2 to 50% by weight, the thickener is 10 to 40% by weight, the water-soluble dispersant is 30 to 85% by weight, the carbonate is 0.1 to 10% by weight, Is 70 to 97.5% by weight, the thickener is 0.5 to 20% by weight, the weight ratio of the granular material to the viscous composition is 1:10 to 40, and the thickener for the granular material is Is a dextrin, and the water-soluble dispersant of the granular material is sucrose.

  The composition for preparing an external preparation for carbon dioxide of the present invention comprises a water-soluble acid, a thickener, and a water-soluble dispersant, which is another substance different from the thickener, as essential components, and the thickener comprises a water-soluble acid and a water-soluble agent. A granular material mixed with an aqueous dispersant, and a viscous composition containing carbonate, water, and a thickener as essential components and mixed with the granular material at the time of use, and a water-soluble acid for the entire granular material. Is 2 to 50% by weight, the thickener is 10 to 40% by weight, the water-soluble dispersant is 30 to 85% by weight, the carbonate is 0.1 to 10% by weight, Is 70 to 97.5% by weight, the thickener is 0.5 to 20% by weight, the weight ratio of the granular material to the viscous composition is 1:10 to 40, and the granular material has a thickener. May be potato starch, and the water-soluble dispersant of the granular material may be sucrose.

  The composition for preparing an external preparation for carbon dioxide of the present invention comprises a water-soluble acid, a thickener, and a water-soluble dispersant, which is another substance different from the thickener, as essential components, and the thickener comprises a water-soluble acid and a water-soluble agent. A granular material mixed with an aqueous dispersant, and a viscous composition containing carbonate, water, and a thickener as essential components and mixed with the granular material at the time of use, and a water-soluble acid for the entire granular material. Is 2 to 50% by weight, the thickener is 10 to 40% by weight, the water-soluble dispersant is 30 to 85% by weight, the carbonate is 0.1 to 10% by weight, Is 70 to 97.5% by weight, the thickener is 0.5 to 20% by weight, the weight ratio of the granular material to the viscous composition is 1:10 to 40, and the thickener for the granular material is Are xanthan gum, dextrin and potato starch, and wherein the water-soluble dispersant for the granular material is xylitol. It can be.

  The composition for preparing an external preparation for carbon dioxide of the present invention comprises a water-soluble acid, a thickener, and a water-soluble dispersant, which is another substance different from the thickener, as essential components, and the thickener comprises a water-soluble acid and a water-soluble agent. A granular material mixed with an aqueous dispersant, and a viscous composition containing carbonate, water, and a thickener as essential components and mixed with the granular material at the time of use, and a water-soluble acid for the entire granular material. Is 2 to 50% by weight, the thickener is 10 to 40% by weight, the water-soluble dispersant is 30 to 85% by weight, the carbonate is 0.1 to 10% by weight, Is 70 to 97.5% by weight, the thickener is 0.5 to 20% by weight, the weight ratio of the granular material to the viscous composition is 1:10 to 40, and the thickener for the granular material is Are dextrin and hydroxypropylcellulose, and the water-soluble dispersant for the granules is D-sorbitol. It can be in the configuration.

  The composition for preparing an external preparation for carbon dioxide of the present invention comprises a water-soluble acid, a thickener, and a water-soluble dispersant, which is another substance different from the thickener, as essential components, and the thickener comprises a water-soluble acid and a water-soluble agent. A granular material mixed with an aqueous dispersant, and a viscous composition containing carbonate, water, and a thickener as essential components and mixed with the granular material at the time of use, and a water-soluble acid for the entire granular material. Is 2 to 50% by weight, the thickener is 10 to 40% by weight, the water-soluble dispersant is 30 to 85% by weight, the carbonate is 0.1 to 10% by weight, Is 70 to 97.5% by weight, the thickener is 0.5 to 20% by weight, the weight ratio of the granular material to the viscous composition is 1:10 to 40, and the thickener for the granular material is Are dextrin and xanthan gum, and the water-soluble dispersant for the granular material is D-mannitol. Can.

The composition for preparing an external preparation for carbon dioxide of the present invention comprises a water-soluble acid, a thickener, and a water-soluble dispersant, which is another substance different from the thickener, as essential components, and the thickener comprises a water-soluble acid and a water-soluble agent. A granular material mixed with an aqueous dispersant, and a viscous composition containing carbonate, water, and a thickener as essential components and mixed with the granular material at the time of use, and a water-soluble acid for the entire granular material. Is 2 to 50% by weight, the thickener is 10 to 40% by weight, the water-soluble dispersant is 30 to 85% by weight, the carbonate is 0.1 to 10% by weight, Is 70 to 97.5% by weight, the thickener is 0.5 to 20% by weight, the weight ratio of the granular material to the viscous composition is 1:10 to 40, and the thickener for the granular material is Are xanthan gum, dextrin and hydroxypropylcellulose, and the water-soluble dispersant of the particulate matter is urea. It can be in a certain configuration.
The granules of the composition for preparing a carbon dioxide external preparation of the present invention are preferably granules.

  According to the composition for external preparation of carbon dioxide of the present invention, the preparation can be easily performed in a short time, without staining clothes and the like, and a stronger cosmetic and medical effect can be obtained in a shorter time. Can be prepared.

The composition for preparing a carbon dioxide external preparation of the present invention comprises a granular material and a viscous composition, wherein the granular material contains a water-soluble acid, a thickener, and a water-soluble dispersant as essential components, and the thickener is a water-soluble acid. And a water-soluble dispersant. The viscous composition contains carbonate, water and a thickener as essential components, and is mixed with the granular material at the time of use.
The viscous composition is applied to an end of a glass plate having a smooth surface of 21 cm or more by coating 1 g of the viscous composition in a disk shape having a diameter of 1 cm, and arranging the viscous composition on a horizontal surface so that the viscous composition comes to an upper side. It is a viscous composition having a viscosity such that a moving distance after 5 seconds when moved up at an angle of 20 degrees is 20 cm or less, and includes gels, pastes, jellies, creams, ointments and the like. However, when the glass plate is set upright and the moving distance after 10 minutes is 1 cm or less, it is excluded.

In the composition for preparing an external agent for carbon dioxide, the granular material contains a water-soluble acid and a water-soluble dispersant in an amount of 32 to 90% by weight based on the whole granular material, and the composition ratio of the water-soluble substance is relatively high. Further, the water content of the viscous composition is relatively high at 70 to 97.5% by weight. For this reason, when the granules and the viscous composition are mixed, the water-soluble substance dissolves quickly, and the granules easily disintegrate.
In order for the thickener in the granular material to rapidly dissolve or swell upon contact with water, the larger the contact area between the thickener and water is, the more preferable it is. Since the total surface area of the thickener increases as the particle size becomes smaller, the thickener used for the granular material is preferably in the form of particles, and the smaller the particle diameter, the more preferable. The particles of the thickener in the particulate matter are dispersed in both water-soluble substances of the water-soluble acid and the water-soluble dispersant, and the water-soluble substance separates the particles of the thickener from each other, When in contact with water, all thickener particles rapidly dissolve or swell to become viscous. For this reason, even if the initial viscosity of the viscous composition is not so high, a carbon dioxide external preparation having a sufficient viscosity can be prepared in a short time without forming "dama" or "mamako".
In order to dissolve or swell the thickener quickly or to keep the reaction between the water-soluble acid and the carbonate unbalanced, a thickener, a water-soluble acid, and a water-soluble dispersant should be used in the granular material. It is preferred that they are mixed as uniformly as possible. The water-soluble acid and the water-soluble dispersant are also preferably in the form of particles, and the smaller the particle diameter, the more preferable.

  In the composition for preparing a carbon dioxide external preparation, the dosage form of the granular material is not particularly limited, and includes granules, fine granules, powder, and the like. The granules include microcapsules, but ordinary granules or fine granules or powders are advantageous in terms of production cost. The granular material is not particularly limited as long as the thickener is as fine as possible and the water-soluble acid and the water-soluble dispersant are mixed and dispersed as uniformly as possible. For example, the water-soluble acid, the water-soluble dispersant, and the thickener are all powders, and may be a powder in which the water-soluble acid and the water-soluble dispersant are all uniformly mixed. In addition, the powder may be formed into granules or fine particles using a suitable solvent or a binder, etc., in this case, not only is it easy to handle, but it takes some time for granules or fine particles to disintegrate, When mixed with the viscous composition, the carbon dioxide generation reaction gradually progresses, granules or fine particles are evenly distributed in the viscous composition, and the generated carbon dioxide is evenly contained in the carbon dioxide external preparation, and in the outside air. It is more preferable because there is no fear of divergence. In addition, depending on the type of the thickener, it can be used as a binder in some cases.

In the composition for preparing a carbon dioxide external preparation, when the granular material is made into a fine powder, when mixed with the viscous composition, carbon dioxide is generated before the two are sufficiently mixed and diffuses into the outside air. I will. In addition, since the distance between the particles of the thickener is too short, the thickener is aggregated before it dissolves or swells and becomes `` dama '' or `` mamako '', so the prepared carbon dioxide external preparation is It is not preferable because the viscosity does not increase so much, the carbon dioxide content is low, and carbon dioxide is not evenly contained. In the case of a solid preparation having a relatively large volume, such as a tablet or capsule, which takes a long time to dissolve the granule, not only takes time to reach a viscosity suitable for use, but also generates carbon dioxide. It is not preferable because it is not evenly contained in the carbon dioxide external preparation.
The surface shape of the granular material is not particularly limited, but is preferably a concavo-convex shape having a large surface area from the viewpoint of the dissolution rate, and more preferably porous having high water absorption efficiency. Depending on the properties of the components, these granules may be obtained by a known granule production method such as a fluidized bed granulation method, a stirring granulation method, a dry crushing granulation method, a wet crushing granulation method, and an extrusion granulation method. Can be manufactured using.

  In the composition for preparing a carbon dioxide external preparation, as the water-soluble acid of the granular material, at least one selected from the group consisting of organic acids and inorganic acids can be used. The compounding amount of the acid is preferably 2 to 50% by weight, more preferably 10 to 35% by weight, and still more preferably 15 to 25% by weight based on the whole granular material. If the amount of the acid is less than 2% by weight, the generation rate of carbon dioxide is low, and the amount of carbon dioxide generated is too small to obtain sufficient cosmetic or medical effects by carbon dioxide. On the other hand, if the content is 50% by weight or more, the amount of carbon dioxide generated is too large, and the amount of bubbles contained in the external preparation is too large, so that an external preparation having a sufficient viscosity cannot be prepared.

In the composition for preparing a carbon dioxide external preparation, as the organic acid of the water-soluble acid of the granular material, for example, oxalic acid, malonic acid, succinic acid, glutaric acid, adipic acid, pimelic acid, fumaric acid, maleic acid, phthalic acid Dicarboxylic acids such as isophthalic acid and terephthalic acid, acidic amino acids such as glutamic acid and aspartic acid, glycolic acid, malic acid, tartaric acid, ittartaric acid, citric acid, isocitric acid, lactic acid, hydroxyacrylic acid, α-oxybutyric acid, glyceric acid And oxy acids such as tartronic acid, salicylic acid, gallic acid, tropic acid, ascorbic acid and gluconic acid, and one or more of these are used.
Examples of the inorganic acid include phosphoric acid, potassium dihydrogen phosphate, sodium dihydrogen phosphate, sodium sulfite, potassium sulfite, sodium pyrosulfite, potassium pyrosulfite, sodium acid hexametaphosphate, potassium hexametaphosphate, and sodium pyrophosphate , Potassium acid pyrophosphate and sulfamic acid, and one or more of these are used. Among these, glycolic acid, malic acid, tartaric acid, citric acid, isocitric acid, salicylic acid, sodium dihydrogen phosphate, sodium acid hexametaphosphate, sodium acid pyrophosphate, and sulfamic acid are preferable, and malic acid, tartaric acid, citric acid, Sodium dihydrogen phosphate is more preferred in terms of effect and usability, and malic acid is most preferred in terms of production because it has no hygroscopicity and is easy to handle.

In the composition for preparing a carbon dioxide external preparation, as the thickener, one or more selected from the group consisting of natural polymers, semi-synthetic polymers, synthetic polymers, and inorganic substances can be used.
Examples of the natural polymer include gum arabic, carrageenan, galactan, agar, quince seed, guar gum, tragacanth gum, pectin, mannan, locust bean gum, rice starch, flour starch, corn starch, potato starch and other plant-based polymers, Microbial polymers such as curdlan, xanthan gum, succinoglucan, dextran, hyaluronic acid, pullulan, and protein-based polymers such as albumin, casein, collagen, gelatin, fibroin, and one or more of these are used. .
Semi-synthetic polymers include ethyl cellulose, modified starch, carboxymethyl cellulose and its salts, carboxymethyl ethyl cellulose and its salts, carboxymethyl starch and its salts, croscarmellose and its salts, crystalline cellulose, cellulose acetate, cellulose acetate phthalate, Cellulose polymers such as hydroxyethyl cellulose, hydroxypropyl starch, hydroxypropyl cellulose, hydroxypropyl methyl cellulose, hydroxypropyl methyl cellulose phthalate, powdered cellulose, methyl cellulose, methyl hydroxypropyl cellulose, pregelatinized starch, partially pregelatinized starch, carboxymethyl starch, dextrin , Starch-based polymers such as methyl starch, alginic acid, sodium alginate, Alginate polymers such as Gin acid propylene glycol ester, sodium chondroitin sulfate, and other polysaccharide polymers such as sodium hyaluronate, and the like, one or more of these can be used.
As the synthetic polymer, for example, carboxyvinyl polymer, sodium polyacrylate, polyvinyl acetal diethylaminoacetate, polyvinyl alcohol, polyvinylpyrrolidone, methacrylic acid-ethyl acrylate copolymer, methacrylic acid-ethyl methacrylate copolymer, ethyl methacrylate Trimethylammonium ethyl methacrylate copolymer, dimethylaminoethyl methacrylate-methyl methacrylate copolymer, and one or more of these are used.
Examples of the inorganic substance include hydrated silicon dioxide, light anhydrous silicic acid, colloidal alumina, bentonite, and laponite, and one or more of these are used.

In the composition for preparing an external preparation for carbon dioxide, as the thickener of the granular material, processed starch, pregelatinized starch, carboxymethyl starch, dextrin, xanthan gum, hydroxypropylcellulose, and polyvinylpyrrolidone are preferable from the aspect of dissolution or swelling rate. , Modified starch, dextrin, xanthan gum, hydroxypropylcellulose, and polyvinylpyrrolidone are more preferable in terms of usability and the like.
The content of the thickener in the granular material is preferably from 10 to 40% by weight, more preferably from 15 to 35% by weight, and still more preferably from 20 to 30% by weight, based on the whole granular material. If the amount of the thickener of the granular material is 10% by weight or less, the viscosity of the external preparation formed when the granular material and the viscous composition are mixed is insufficient. If the amount of the thickener of the granular material is 40% by weight or more, the disintegration, dispersion, and dissolution of the granular material become slow when the granular material and the viscous composition are mixed, and it takes too much time to prepare the external preparation.

  In the composition for preparing an external agent for carbon dioxide, the water-soluble dispersant for the particulate matter is not particularly limited as long as it is easily soluble in water, chemically stable, and can be used in the form of particles. For example, pregelatinized starch, starch derivatives such as α-cyclodextrin, sucrose, glucose, fructose, sucrose, lactose, saccharides such as xylitol, D-sorbitol, D-mannitol, polysaccharides such as pullulan and xanthan gum, hydroxypropylcellulose, hydroxy Examples include cellulose derivatives and salts thereof such as propylmethylcellulose, carmellose calcium and carmellose sodium, synthetic polymers such as polyvinylpyrrolidone, and urea, and one or more of these are used. Among these, saccharides and urea are preferred, and xylitol, D-sorbitol, glucose, D-mannitol, fructose, sucrose, lactose, sucrose, and urea are more preferred.

Water-soluble acids also function as water-soluble dispersants. However, even if the granules contain a water-soluble acid and a thickener as essential components, they do not contain a water-soluble dispersant and other water-soluble additives, and the thickener is mixed with the water-soluble acid, When the particles of the thickener are scattered therein and the particles of the thickener are separated from each other by a water-soluble acid, when the particulate matter is mixed with the viscous composition, the thickener is sufficiently dissolved in water or Before the swelling and the viscosity of the viscous composition increase, the reaction between the acid and the carbonate proceeds, and the generated carbon dioxide diverges into the outside air, and the thickener becomes “dama” or “mamako”. As a result, a carbon dioxide external preparation having a sufficient viscosity cannot be obtained.
Some of the water-soluble dispersants can be used as a thickener, and some of the thickeners can be used as a water-soluble dispersant.

  In the composition for preparing a carbon dioxide external preparation, the carbonate of the viscous composition is not particularly limited as long as it reacts with an acid to generate carbon dioxide. For example, ammonium carbonate, ammonium bicarbonate, potassium carbonate, potassium bicarbonate, potassium sesquicarbonate, sodium carbonate, sodium bicarbonate, sodium sesquicarbonate, lithium carbonate, lithium bicarbonate, lithium sesquicarbonate, cesium carbonate, cesium bicarbonate, sesquicarbonate Cesium, magnesium carbonate, magnesium hydrogen carbonate, calcium hydrogen carbonate, calcium carbonate, magnesium carbonate hydroxide, barium carbonate are used, and one or more of these are used. The compounding amount of the carbonate is preferably from 0.1 to 10% by weight, more preferably from 0.5 to 6% by weight, further preferably from 1 to 3% by weight, based on the whole viscous composition. If the amount of the carbonate is less than 0.1% by weight, no matter how much the amount of the acid that reacts with the carbonate, the amount of carbon dioxide generated is small, so that a beauty or medical effect cannot be obtained. If the compounding amount of the carbonate is 10% by weight or more, this is mixed with a granular material containing an acid in an amount equal to or more than the reaction chemistry, and when reacted, the amount of generated carbon dioxide is too large, and Not only does it diverge and is not used for percutaneous transmucosal absorption, but the prepared carbon dioxide external preparation also contains too many air bubbles, the thickening effect of the thickener contained in the particulate matter is negated, and the adhesiveness decreases. The external preparation does not adhere to the skin and mucous membranes. Therefore, not only is it difficult to use, but also a sufficient beauty or medical effect cannot be obtained.

  In the composition for preparing a carbon dioxide external preparation, the water of the viscous composition is not particularly limited as long as it can be used for the production of ordinary cosmetics, pharmaceuticals, and the like, such as distilled water, membrane filtered water, and ion-exchanged water. Can be used as appropriate. The blending amount of water is preferably 70 to 97.5% by weight, more preferably 75 to 95% by weight, and still more preferably 80 to 92.5% by weight based on the whole viscous composition. When the blending amount of water is 70% by weight or less, the viscosity of the viscous composition is too high and lacks fluidity, flexibility, and the like, so that it is difficult to mix the granules, and the granules are evenly distributed in the viscous composition. In addition, it does not spread widely, and the dissolution or swelling of the thickener in the granular material is insufficient due to low water content, so that the increase in viscosity is small and sufficient cosmetic or medical effect cannot be obtained. When the blending amount of water is 97.5% by weight or more, when the granular material is mixed with the viscous composition, the water-soluble acid dissolves too quickly, and carbon dioxide is suddenly generated and diffuses into the outside air. The content in the prepared carbon dioxide external preparation is reduced, the viscosity of the viscous composition is less increased, and the obtained carbon dioxide external preparation is not only poor in usability because it drips when applied to the skin and mucous membranes, Sufficient beauty or medical effects cannot be obtained.

In the composition for preparing a carbon dioxide external preparation, as the thickener of the viscous composition, an alginic acid-based polymer, a cellulose-based polymer, or a synthetic polymer is preferable, and sodium alginate, propylene glycol alginate, carboxymethyl cellulose, and salts thereof. , Carboxymethyl starch and salts thereof, carboxyvinyl polymer, and polyvinylpyrrolidone are more preferred in terms of usability and the like, and sodium alginate, propylene glycol alginate and sodium carboxymethylcellulose are even more preferred in terms of usability.
In the viscous composition, the compounding amount of the thickener is preferably 0.5 to 20% by weight, more preferably 1 to 10% by weight, and still more preferably 2 to 5% by weight. . If the compounding amount of the thickener in the viscous composition is 0.5% by weight or less, the viscosity is too low, so that a sufficient viscosity cannot be obtained even when a granular material is added. If the compounding amount of the thickener in the viscous composition is 20% by weight or more, the viscosity is too high to mix with the granular material, and even if the mixture is forcedly mixed, sufficient disintegration of the granular material is not sufficient, so that carbon dioxide is sufficient. Since it does not occur, or if it occurs, it takes a long time to mix, so that carbon dioxide diverges into the outside air on the way and is not sufficiently utilized for transdermal transmucosal absorption, and it is difficult to obtain a cosmetic or medical effect.

The carbon dioxide external preparation obtained from the composition for preparing a carbon dioxide external preparation is slightly alkaline to weakly acidic and does not soak into wounds. The hydrogen ion index of the external preparation is preferably from pH 4 to 9, and more preferably from pH 5 to 8, from the viewpoint of irritation.
The viscous composition of the composition for preparing an external carbon dioxide preparation has good usability as it is, but by adding a polyhydric alcohol to the skin and mucous membranes of the external preparation for carbon dioxide obtained by mixing with a particulate material. Since the adhesiveness and elongation are further improved, the usability is further improved, and the effect is further ensured. The blending amount of the polyhydric alcohol is preferably from 1 to 15% by weight of the viscous composition, more preferably from 3 to 10% by weight. If the amount is less than 1% by weight, the above-mentioned effects cannot be obtained. If the amount is more than 15% by weight, the viscosity of the external preparation becomes low, and it is unpreferable because it droops and flows when applied to the skin and mucous membranes.

  The polyhydric alcohol is not particularly limited and includes, for example, glycols such as ethylene glycol, diethylene glycol, propylene glycol, dipropylene glycol, 1,3-butylene glycol, polyethylene glycol, neopentyl glycol, spiro glycol, glycerin, diglycerin, Glycerols such as polyglycerin, diols such as 1,3-butanediol, 1,4-butanediol, 1,6-hexanediol, 1,8-octanediol, and 1,10-decanediol are exemplified. One or more are used. Among these, 1,3-butylene glycol and glycerin are particularly preferable because they are excellent in balance between viscosity and elongation and viscosity, and have moisture retention.

  The carbon dioxide external preparation preparation composition, in addition to the essential components, as long as the effects of the present invention are not impaired, raw materials usually used for external preparations and cosmetics, such as fragrances, pigments, surfactants, oils, Moisturizers, alcohols, preservatives, antioxidants, sequestering agents, coloring inhibitors, ultraviolet absorbers / scatterers, vitamins, amino acids, arbutin, kojic acid, nutrients, anti-inflammatory agents, vasodilators, Agents such as hormonal agents, astringents, antihistamines, bactericides, sebum suppressants, exfoliants / keratolytics, antiseborrheic agents, and antipruritic agents can be added. Thereby, the carbon dioxide external preparation can be suitably used as a cosmetic or an external medicine.

The composition for preparing a carbon dioxide external preparation of the present invention may be stored in a state where the granular material and the viscous composition are not in contact with each other, and it is particularly preferable that both of them are stored in a closed state. The storage container can be used without any particular limitation on the material, shape, structure, etc. Examples of the material include plastic, glass, aluminum, paper, various polymers and composites of these materials, and the shape and structure are cups. , Tubes, bags, bottles, sticks, pumps, any of which can be used without limitation. Among these, especially for granular materials, aluminum sticks or aluminum bags whose inner surfaces are laminated with polyethylene terephthalate, aluminum sticks or aluminum bags whose viscous compositions are laminated with polyethylene terephthalate, or aluminum whose inner surfaces are laminated with polyethylene terephthalate A polyethylene terephthalate cup in which the lid is heel-sheeted with a sheet is preferred from the viewpoints of airtightness, storage stability of the contents, production costs, and the like.
In the composition for preparing a carbon dioxide external preparation, the mixing of the granular material and the viscous composition may be performed using an appropriate container such as glass or plastic, or may be performed on the palm or on the mucous membrane of the skin. . The mixing of the granular material and the viscous composition may be performed by a finger or the like, or a tool such as a butter knife or a spatula may be used. The granules may be mixed until completely dissolved in the viscous composition, or the granules may be dissolved only about half. In the latter case, even if applied directly to the skin and mucous membranes, the particulate matter rapidly dissolves, so that an effect similar to that obtained when the application time is not extremely short can be obtained.

  The composition for preparing a carbon dioxide external preparation is preferably 10 to 40 parts by weight, more preferably 15 to 35 parts by weight, still more preferably 20 to 30 parts by weight, based on 1 part by weight of the granular material. It is. When the viscous composition is 10 parts by weight or less with respect to 1 part by weight of the granular material, when the both are mixed to prepare an external preparation for carbon dioxide, the generation of carbon dioxide is intense and the amount is too large, so that carbon dioxide diverges into the outside air. In addition, the resulting external preparation for carbon dioxide contains too many air bubbles, lowers the viscosity, and impairs the adhesion to the skin and mucous membranes. As a result, it is difficult to obtain a sufficient cosmetic or medical effect. When the viscous composition is 40 parts by weight or more with respect to 1 part by weight of the granular material, it takes a long time to uniformly disperse the granular material in the viscous composition, and carbon dioxide generated during the time is easily diverged into the outside air. In addition, since the amount of carbon dioxide generated is small, beauty and medical effects are weakened.

The coating thickness of the carbon dioxide external preparation obtained from the composition for preparing a carbon dioxide external preparation is preferably from 0.2 to 10 mm, more preferably from 0.5 to 5 mm, and still more preferably from 1 to 3 mm. If the thickness of the coating is 0.2 mm or less, it is difficult to obtain a cosmetic or medical effect, and if it is 10 mm or more, not only is it difficult to apply, but also no further effect is obtained.
The application time of the carbon dioxide external preparation is preferably 5 minutes to 3 hours for cosmetic purposes, more preferably 10 minutes to 2 hours, and even more preferably 15 minutes to 1 hour. If the application time is shorter than 5 minutes, the cosmetic effect is weak, and if it is longer than 3 hours, no further effect is obtained, and the skin becomes swollen. The application time for medical purposes is similar to that for cosmetic purposes, but when used for deep wounds such as bedsores, application for 24 hours or more is effective.

  The composition for external preparation of carbon dioxide having the above constitution is easy to prepare the external preparation of carbon dioxide, and the prepared external preparation of carbon dioxide contains a large amount of carbon dioxide evenly throughout, and has a sufficient viscosity and tackiness. A portion that comes into contact with the outside air forms a film to suppress the emission of carbon dioxide, and does not sag or decrease in thickness when applied to the skin and mucous membranes. For this reason, athlete's foot, insect bites, atopic dermatitis, monetary eczema, xerosis, seborrheic eczema, urticaria, prurigo, housewife eczema, acne vulgaris, compared to conventional carbon dioxide external preparations Impetigo, folliculitis, bunches, cough, cellulitis, pyoderma, psoriasis, ichthyosis, palmoplantar keratosis, lichen, pityriasis, wounds, burns, cracks, erosions, erythema, etc. Itching due to mucosal disease or mucosal disorders of the skin, pressure sores, wounds, burns, stomatitis, stomatitis, skin ulcers, cracks, erosions, frost acne, gangrene, etc .; failure to engraft skin grafts, flaps, etc. ; Dental diseases such as gingivitis, alveolar pyorrhea, denture ulcer, melanized gingiva, stomatitis; Based on peripheral circulatory disorders such as obstructive thrombositis, obstructive atherosclerosis, diabetic peripheral circulatory dysfunction, varicose veins Skin ulcers, cold sensation, numbness; rheumatoid arthritis, cervico-brachial syndrome, muscle pain, arthralgia, lumbago Which musculoskeletal diseases; nervous system diseases such as neuralgia, polyneuritis, Smon's disease; dyskeratosis such as psoriasis, chicken eyes, octopus, ichthyosis, palmoplantar keratosis, lichen, pityriasis; Purulent skin diseases such as acne, impetigo, folliculitis, bunches, cough, cellulitis, pyoderma, purulent eczema; suppression of recurring hair after hair removal (waste hair treatment); freckles, rough skin The effect on cosmetic problems such as skin and hair, such as dullness of the skin, weakening of the skin, weakening of the luster of the skin, and weakening of the luster of the hair, and partial obesity are more powerful, and the effect is expressed earlier.

Next, the composition for preparing a carbon dioxide external preparation of the present invention will be specifically described with reference to examples, but the present invention is not limited to these examples.
(Example 1)
Manufacture of granules 50 parts by weight of lactose as a water-soluble dispersant, 30 parts by weight of citric acid as a water-soluble acid, 7 parts by weight of processed starch, 3 parts by weight of dextrin, and 10 parts by weight of potato starch were used. A porous columnar granule having a length of about 4 mm and a diameter of about 1 mm was produced by a wet extrusion granulation method. The yield of this particulate was about 60%.
Production of viscous composition 4.0 parts by weight of sodium hydrogen carbonate as a carbonate are dissolved in 91.5 parts by weight of purified water, and while gradually heating to 60 ° C., 1.5 parts by weight of sodium alginate as a thickener, carboxymethyl cellulose 3.0 parts by weight of sodium was gradually added and dissolved with stirring. After dissolution, the solution was allowed to stand overnight and cooled to room temperature to produce a viscous composition.
The granular material and the viscous composition were combined to prepare a composition for preparing a carbon dioxide external preparation.

(Example 2)
Production of granules 65 parts by weight of xylitol as a water-soluble dispersant, 15 parts by weight of sodium dihydrogen phosphate as a water-soluble acid, 10 parts by weight of dextrin as a thickener, 10 parts by weight of corn starch, and a wet process using water as a solvent Porous columnar granules having a length of about 4 mm and a diameter of about 1 mm were produced by extrusion granulation. The yield of this particulate was about 65%.
Production of viscous composition In 92.5 parts by weight of purified water, 1.5 parts by weight of sodium hydrogencarbonate as a carbonate, 0.1 parts by weight of methyl paraben as a preservative, 1.0 parts by weight of phenoxyethanol, and oak extract 0. 1 part by weight, 0.1 part by weight of chamomile extract, 0.1 part by weight of rosewood extract and 0.1 part by weight of perilla extract are dispersed and dissolved, and while gradually heating to 60 ° C., sodium alginate 2.5 Parts by weight and 2.0 parts by weight of sodium carboxymethylcellulose were gradually added and dissolved with stirring. After dissolution, the mixture was allowed to stand overnight and cooled to room temperature to produce a viscous composition.
The granular material and the viscous composition were combined to prepare a composition for preparing a carbon dioxide external preparation.

(Example 3)
Production of Granules Wet extrusion granulation using 60 parts by weight of lactose as a water-soluble dispersant, 20 parts by weight of citric acid as a water-soluble acid, 10 parts by weight of dextrin and 10 parts by weight of potato starch as a thickener, and using water as a solvent. The method produced porous columnar granules having a length of about 4 mm and a diameter of about 1 mm. The yield of this particulate was about 65%.
Production of viscous composition 3.0 parts by weight of sodium hydrogencarbonate as a carbonate in 88.5 parts by weight of purified water, and 0.1 parts by weight of each of sow pork extract, panax ginseng extract, perilla extract, sicon extract and rosemary extract as other raw materials, Dissolve 3.0 parts by weight of 1,2-pentanediol as a preservative and gradually add 3.0 parts by weight of sodium alginate and 2.0 parts by weight of sodium carboxymethylcellulose as a thickener while gradually heating to 60 ° C. The mixture was dissolved with stirring, left to stand overnight after dissolution, and cooled to room temperature to produce a viscous composition.
0.7 g of the granular material is hermetically filled in an aluminum stick having an inner surface laminated with polyethylene terephthalate, and 15 g of the viscous composition is hermetically filled in an aluminum pouch having an inner surface laminated with polyethylene terephthalate to combine the granular material and the viscous composition. To obtain a composition for preparing an external preparation for carbon dioxide.

(Example 4)
Production of Granules 50 parts by weight of lactose as a water-soluble dispersant, 30 parts by weight of malic acid as a water-soluble acid, 7 parts by weight of processed starch, 3 parts by weight of dextrin, 10 parts by weight of potato starch, A porous columnar granule having a length of about 4 mm and a diameter of about 1 mm was produced by a wet extrusion granulation method. The yield of this particulate was about 95%.
Production of viscous composition 4.0 parts by weight of sodium hydrogen carbonate as a carbonate are dissolved in 91.5 parts by weight of purified water, and while gradually heating to 60 ° C., 1.5 parts by weight of sodium alginate as a thickener, carboxymethyl cellulose 3.0 parts by weight of sodium was gradually added and dissolved with stirring. After dissolution, the solution was allowed to stand overnight and cooled to room temperature to produce a viscous composition.
The granular material and the viscous composition were combined to prepare a composition for preparing a carbon dioxide external preparation.

(Example 5)
Production of Granules 50 parts by weight of lactose as a water-soluble dispersant, 20 parts by weight of tartaric acid as a water-soluble acid, 10 parts by weight of processed starch, 10 parts by weight of dextrin, and 10 parts by weight of potato starch as a thickener were used. The porous columnar granules having a length of about 4 mm and a diameter of about 1 mm were produced by a wet extrusion granulation method. The yield of this particulate was about 95%.
Production of viscous composition 3.0 parts by weight of sodium hydrogencarbonate as a carbonate in 88.5 parts by weight of purified water, and 0.1 parts by weight of each of sow pork extract, panax ginseng extract, perilla extract, sicon extract and rosemary extract as other raw materials, Dissolve 3.0 parts by weight of 1,2-pentanediol as a preservative, gradually add 3.0 parts by weight of propylene glycol alginate and 2.0 parts by weight of sodium carboxymethylcellulose as a thickener while gradually heating to 60 ° C. And melted with stirring, left overnight after dissolution, and cooled to room temperature to produce a viscous composition.
1.5 g of the granular material is hermetically filled in an aluminum stick having an inner surface laminated with polyethylene terephthalate, 30 g of the viscous composition is filled in a 50 ml capacity hemispherical cup of polyethylene terephthalate, and the upper surface is an aluminum sheet laminated with polyethylene terephthalate. It was heat-sealed. One aluminum stick-filled granular material and one hemispherical cup-filled viscous composition were combined to prepare a composition for preparing an external agent for carbon dioxide.

(Example 6)
Production of Granules 73 parts by weight of lactose as a water-soluble dispersant, 7 parts by weight of malic acid as a water-soluble acid, 7 parts by weight of processed starch, 3 parts by weight of dextrin, and 10 parts by weight of potato starch were used. A porous columnar granule having a length of about 4 mm and a diameter of about 1 mm was produced by a wet extrusion granulation method. The yield of this particulate was about 95%.
Production of viscous composition 2.0 parts by weight of sodium bicarbonate as a carbonate, 1.0 part by weight of phenoxyethanol as a preservative, and 2.0 parts by weight of 1,3-butylene glycol as a polyhydric alcohol in 90.5 parts by weight of purified water While gradually heating to 60 ° C., gradually adding 1.5 parts by weight of propylene glycol alginate and 3.0 parts by weight of sodium carboxymethylcellulose as a thickener, dissolving with stirring, and allowing to stand overnight after dissolution. Upon cooling to room temperature, a viscous composition was produced.
The granular material and the viscous composition were combined to prepare a composition for preparing a carbon dioxide external preparation.

(Example 7)
Using 50 parts by weight of sucrose as a water-soluble dispersant, 20 parts by weight of malic acid as a water-soluble acid, 15 parts by weight of dextrin as a thickener, and 15 parts by weight of potato starch, the length of which is determined by wet extrusion granulation using water as a solvent. Porous columnar granules having a diameter of about 4 mm and a diameter of about 1 mm were produced. The yield of this particulate was about 95%.
Production of viscous composition 3.0 parts by weight of sodium hydrogencarbonate as a carbonate in 89.0 parts by weight of purified water, 0.5 part by weight of 1,2-pentanediol as a preservative, 1,3-butylene glycol as a polyhydric alcohol Dissolve 3.0 parts by weight, gradually add 1.5 parts by weight of propylene glycol alginate and 3.0 parts by weight of sodium carboxymethylcellulose as a thickener while gradually heating to 60 ° C., dissolve with stirring, and dissolve. Thereafter, the mixture was left overnight and cooled to room temperature to produce a viscous composition.
The granular material and the viscous composition were combined to prepare a composition for preparing a carbon dioxide external preparation.

(Example 8)
Production of Granules 55 parts by weight of lactose as a water-soluble dispersant, 25 parts by weight of citric acid as a water-soluble acid, 7 parts by weight of processed starch, 3 parts by weight of dextrin, and 10 parts by weight of potato starch, and water was used as a solvent. A porous columnar granule having a length of about 4 mm and a diameter of about 1 mm was produced by a wet extrusion granulation method. The yield of this particulate was about 65%.
Manufacture of viscous composition It manufactured according to manufacture of the viscous composition of the comparative example 2 mentioned later.
The granular material and the viscous composition were combined to prepare a composition for preparing a carbon dioxide external preparation.

(Example 9)
Production of Granules Using 60 parts by weight of lactose as a water-soluble dispersant, 25 parts by weight of malic acid as a water-soluble acid, and 15 parts by weight of processed starch as a thickener, and having a length of about 15 parts by wet extrusion granulation using water as a solvent. Porous columnar granules having a diameter of 4 mm and a diameter of about 1 mm were produced. The yield of this particulate was about 95%.
Production of viscous composition The viscous composition was produced according to the production of the viscous composition of Example 6.
The granular material and the viscous composition were combined to prepare a composition for preparing a carbon dioxide external preparation.

(Example 10)
Manufacture of granules 60 parts by weight of a water-soluble dispersant, 30 parts by weight of malic acid as a water-soluble acid, 10 parts by weight of dextrin as a thickener, and a length of about 4 mm by wet extrusion granulation using water as a solvent. To produce porous columnar granules having a diameter of about 1 mm. The yield of this particulate was about 95%.
Production of viscous composition The viscous composition was produced according to the production of the viscous composition of Example 6.
The granular material and the viscous composition were combined to prepare a composition for preparing a carbon dioxide external preparation.

(Example 11)
Manufacture of granules 50 parts by weight of sucrose as a water-soluble dispersant, 30 parts by weight of malic acid as a water-soluble acid, and 20 parts by weight of potato starch as a thickener are mixed well, and the mixture is subjected to wet extrusion granulation using water as a solvent. Porous columnar granules about 4 mm in diameter and about 1 mm in diameter were produced. The yield of this particulate was about 95%.
Production of viscous composition The viscous composition was produced according to the production of the viscous composition of Example 6.
The granular material and the viscous composition were combined to prepare a composition for preparing a carbon dioxide external preparation.

(Example 12)
Preparation of granules 50 parts by weight of lactose as a water-soluble dispersant, 30 parts by weight of malic acid as a water-soluble acid, 7 parts by weight of processed starch, 3 parts by weight of dextrin, and 10 parts by weight of potato starch are thoroughly mixed with water. Was used as a solvent to produce porous columnar granules having a length of about 4 mm and a diameter of about 1 mm by a wet extrusion granulation method. The yield of this particulate was about 95%.
Production of viscous composition In 91 parts by weight of purified water, 4.0 parts by weight of sodium bicarbonate was dissolved as a carbonate, and 5 parts by weight of sodium alginate as a thickener was gradually added while gradually heating to 60 ° C., followed by stirring. After dissolution, the mixture was allowed to stand overnight, and then cooled to room temperature to produce a viscous composition.
The granular material and the viscous composition were combined to prepare a composition for preparing a carbon dioxide external preparation.

(Example 13)
Production of Granular Material The granular material was produced according to the method for producing a granular material of Example 12.
Production of viscous composition 4.0 parts by weight of sodium hydrogen carbonate as a carbonate were dissolved in 91 parts by weight of purified water, and 5 parts by weight of propylene glycol alginate was gradually added as a thickener while gradually heating to 60 ° C. The mixture was dissolved with stirring, left overnight after dissolution, and cooled to room temperature to produce a viscous composition.
The granular material and the viscous composition were combined to prepare a composition for preparing a carbon dioxide external preparation.

(Example 14)
Production of Granular Material The granular material was produced according to the method for producing a granular material of Example 12.
Production of viscous composition Dissolve 4.0 parts by weight of sodium bicarbonate as a carbonate in 91 parts by weight of purified water, gradually add 5 parts by weight of sodium carboxymethylcellulose as a thickener while gradually heating to 60 ° C., and stir. The mixture was left to stand overnight after dissolution, and cooled to room temperature to produce a viscous composition.
The granular material and the viscous composition were combined to prepare a composition for preparing a carbon dioxide external preparation.

(Example 15)
Preparation of Granules 50 parts by weight of xylitol as a water-soluble dispersant, 30 parts by weight of malic acid as a water-soluble acid, 7 parts by weight of xanthan gum as a thickener, 5 parts by weight of dextrin, and 8 parts by weight of potato starch are sufficiently mixed. Porous columnar granules having a length of about 4 mm and a diameter of about 1 mm were produced by a wet extrusion granulation method using a solvent. The yield of this particulate was about 70%.
Production of viscous composition 3.0 parts by weight of sodium hydrogencarbonate as a carbonate in 89.0 parts by weight of purified water, 0.5 part by weight of 1,2-pentanediol as a preservative, 1,3-butylene glycol as a polyhydric alcohol Dissolve 3.0 parts by weight, gradually add 1.5 parts by weight of sodium alginate and 3.0 parts by weight of sodium carboxymethylcellulose as a thickener while gradually heating to 60 ° C., dissolve with stirring, and overnight after dissolution. It was left to cool to room temperature to produce a viscous composition.
The granular material and the viscous composition were combined to prepare a composition for preparing a carbon dioxide external preparation.

(Example 16)
50 parts by weight of D-sorbitol as a water-soluble dispersant, 20 parts by weight of malic acid as a water-soluble acid, 15 parts by weight of dextrin as a thickener, and 15 parts by weight of hydroxypropylcellulose are sufficiently mixed, and wet extrusion is performed using water as a solvent. Porous columnar granules having a length of about 4 mm and a diameter of about 1 mm were produced by a granulation method. The yield of this particulate was about 65%.
Production of viscous composition In 89.0 parts by weight of purified water, 3.0 parts by weight of sodium carbonate as a carbonate, 0.5 parts by weight of 1,2-pentanediol as a preservative, and 1,3-butylene glycol 3 as a polyhydric alcohol Then, 1.5 parts by weight of propylene glycol alginate and 3.0 parts by weight of sodium carboxymethylcellulose were gradually added as thickeners while gradually warming to 60 ° C., and dissolved while stirring. It was left overnight and cooled to room temperature to produce a viscous composition.
The granular material and the viscous composition were combined to prepare a composition for preparing a carbon dioxide external preparation.

(Example 17)
45 parts by weight of D-mannitol as a water-soluble dispersant, 25 parts by weight of malic acid as a water-soluble acid, 15 parts by weight of dextrin and 15 parts by weight of xanthan gum as a thickener, and wet extrusion granulation using water as a solvent. Produced a porous columnar granule having a length of about 4 mm and a diameter of about 1 mm. The yield of this particulate was about 90%.
Production of viscous composition 3.0 parts by weight of sodium hydrogencarbonate as a carbonate in 88.5 parts by weight of purified water, 1.0 part by weight of 1,2-pentanediol as a preservative, 1,3-butylene glycol as a polyhydric alcohol Dissolve 3.0 parts by weight, gradually add 1.5 parts by weight of sodium alginate and 3.0 parts by weight of sodium carboxymethylcellulose as a thickener while gradually heating to 60 ° C., dissolve with stirring, and overnight after dissolution. It was left to cool to room temperature to produce a viscous composition.
The granular material and the viscous composition were combined to prepare a composition for preparing a carbon dioxide external preparation.

(Example 18)
Manufacture of granules 50 parts by weight of urea as a water-soluble dispersant, 20 parts by weight of tartaric acid as a water-soluble acid, 10 parts by weight of xanthan gum as a thickener, 10 parts by weight of dextrin, and 10 parts by weight of hydroxypropylcellulose are sufficiently mixed, and water is mixed. Porous columnar granules having a length of about 4 mm and a diameter of about 1 mm were produced by a wet extrusion granulation method using a solvent. The yield of this particulate was about 95%.
Manufacture of a viscous composition It manufactured according to manufacture of the viscous composition of Example 7.
1.5 g of the granular material is hermetically sealed in an aluminum stick having an inner surface laminated with polyethylene terephthalate, 30 g of the viscous composition is filled in a 50 ml capacity hemispherical cup of polyethylene terephthalate, and the upper surface is heated with an aluminum sheet laminated with polyethylene terephthalate. Fused. One aluminum stick-filled granular material and one hemispherical cup-filled viscous composition were combined to prepare a composition for preparing an external agent for carbon dioxide.

(Comparative Example 1)
Manufacture of granules Using citric acid 20 parts by weight as a water-soluble acid, hydroxypropylcellulose 30 parts by weight, dextrin 20 parts by weight, and carboxymethyl starch sodium 30 parts by weight as a thickener, about 4 mm in length by wet extrusion granulation. And columnar granules having a diameter of about 1 mm. The yield of this particulate was about 45%.
Production of viscous composition 4.0 parts by weight of sodium hydrogen carbonate as a carbonate are dissolved in 91.5 parts by weight of purified water, and while gradually heating to 60 ° C., 1.5 parts by weight of sodium alginate as a thickener, carboxymethyl cellulose 3.0 parts by weight of sodium was gradually added and dissolved with stirring. After dissolution, the solution was allowed to stand overnight and cooled to room temperature to produce a viscous composition.
The granular material and the viscous composition were combined to prepare a composition for preparing a carbon dioxide external preparation.

(Comparative Example 2)
It was manufactured as follows according to Example 109 of JP-A-2000-319187.
Production of Granules Using citric acid (25 parts by weight), ethyl cellulose (25 parts by weight), and croscarmellose sodium (50 parts by weight), porous columnar granules having a length of about 4 mm and a diameter of about 1 mm were obtained by wet extrusion granulation using water as a solvent. Manufactured.
Production of viscous composition Dissolve 2.4 parts by weight of sodium bicarbonate in 89.6 parts by weight of purified water, and gradually warm to 60 ° C. while 4.0 parts by weight of sodium alginate, 2.0 parts by weight of ethyl cellulose, carboxymethyl cellulose 2.0 parts by weight of sodium was gradually added and dissolved with stirring. After dissolution, the solution was allowed to stand overnight and cooled to room temperature to produce a viscous composition.
The granular material and the viscous composition were combined to prepare a composition for preparing a carbon dioxide external preparation.

(Comparative Example 3)
Production of Water-Soluble Acid-Containing Powder A powder was produced by sufficiently mixing 60 parts by weight of citric acid as a water-soluble acid, 20 parts by weight of dextrin as a thickener, and 20 parts by weight of potato starch. The yield of this particulate was about 100%.
Production of viscous composition 4.0 parts by weight of sodium hydrogen carbonate as a carbonate are dissolved in 91.5 parts by weight of purified water, and while gradually heating to 60 ° C., 1.5 parts by weight of sodium alginate as a thickener, carboxymethyl cellulose 3.0 parts by weight of sodium was gradually added and dissolved with stirring. After dissolution, the solution was allowed to stand overnight and cooled to room temperature to produce a viscous composition.
The water-soluble acid-containing powder and the viscous composition were combined to prepare a composition for preparing an external agent for carbon dioxide.

Evaluation Test The composition for preparing a carbon dioxide external preparation prepared as described above was evaluated as follows.
Evaluation 1: Partial skin thinning, whitening, skin effect (1)
1.4 g of granules or water-soluble acid-containing powders of 21 types of compositions for preparing an external agent for carbon dioxide of Examples 1 to 18 and Comparative Examples 1 to 3 and 30 g of the corresponding viscous composition each having a diameter of 5 cm In a plastic container, a carbon dioxide external preparation was prepared by stirring with a spatula 30 times, and the ease of preparation was evaluated.
Next, 10 g of each prepared external preparation was applied to a thickness of about 1 mm on the right cheek including the jaw of a total of 21 female subjects aged 21 to 42 to observe the dripping condition, and 15 minutes after application, the external preparation was applied. Removed and observed cheek and skin condition.

  As a result, any one of the compositions for preparing a carbon dioxide external preparation of Examples 1 to 18 is easy to mix the granular material and the viscous composition, and the granular material is evenly distributed in the viscous composition, and the carbon dioxide is dissolved. Was sufficiently generated. In particular, any carbon dioxide external preparations prepared from these do not sag when applied to the cheeks of the subject, and after 15 minutes have been removed, all the subjects using the carbon dioxide external preparation of the present invention, Observation by a third party revealed that the cheek on the agent-applied side became smaller than the non-applied area, the mouth angle increased, and the skin became white and transparent. Among these, the external carbon dioxide preparations prepared from the carbon dioxide external preparation preparation compositions of Examples 4, 12, 15, and 17 were particularly excellent in partial skin thinning, whitening, and skin beautiful effects.

  On the other hand, the composition for preparing a carbon dioxide external preparation of Comparative Example 1 was easy to mix the granular material and the viscous composition and generated sufficient carbon dioxide, but the carbon dioxide external preparation prepared from the composition was applied to the cheek of the subject. When it was applied, it fell down immediately after the application and fell off the cheeks, soiling the clothes. When the external preparation was removed 15 minutes after application, the skin was slightly white, but the effect of increasing the corner of the mouth due to the decrease in cheek size was not recognized.

  In the composition for preparing a carbon dioxide external preparation of Comparative Example 2, the particulate matter was hardly dissolved in the viscous composition, and the generation of carbon dioxide was insufficient. When the external preparation for carbon dioxide prepared from this was applied to the cheek of the subject, it dripped immediately after the application and fell off the cheek, and soiled the clothes. When the external preparation was removed 15 minutes after application, the granules still remained undissolved in the external preparation, and although the cheek on the application side of the subject became somewhat white, it was smaller than the non-application side, The mouth angle was raised, and no effect of giving a transparent feeling to the skin was observed.

  In the composition for preparing a carbon dioxide external preparation of Comparative Example 3, as soon as the granules were added to the viscous composition and stirred, the generation of carbon dioxide started near the surface of the viscous composition, and the granules were sufficiently mixed with the viscous composition. Before that happened, the evolution of carbon dioxide had ceased. Also, many "dama" or "mamako" were formed in the viscous composition, and the granular material could not be completely dissolved. When the external preparation for carbon dioxide prepared from this was applied to the cheek of the subject, "dama" or "mamako" still did not disappear, and the external preparation dripped immediately after application and fell off the cheek, and soiled clothes. When the external preparation was removed 15 minutes after application, the skin was slightly white, but the effect of increasing the corner of the mouth due to the decrease in cheek size was not recognized.

Evaluation 2: Partial skin thinning, whitening, skin effect (2)
In a plastic container having a diameter of 5 cm, 1.4 g of the granules of the two types of compositions for preparing an external carbon dioxide agent of Example 8 and Comparative Example 2 were added to 30 g of the viscous composition corresponding to the granules, and a spatula was used. The mixture was stirred 30 times to prepare an external preparation for carbon dioxide. 10 g of the carbon dioxide external preparation prepared from the composition of Example 8 was applied to the right cheek of a 41-year-old female subject, and 10 g of the carbon dioxide external preparation prepared from the composition of Comparative Example 2 was applied to the left cheek. It was applied to about 1.5 mm to observe the dripping condition, and 15 minutes after application, the external preparation was removed to observe the condition of the cheeks and skin. As a result, the external preparation for carbon dioxide prepared from the composition for preparing an external carbon dioxide preparation of Example 8 did not sag even when applied to the right cheek of the subject. Observation by the three persons revealed that the cheek became smaller than the left cheek, the mouth angle increased, and the skin became white and transparent. On the other hand, the carbon dioxide external preparation prepared from the composition for preparing a carbon dioxide external preparation of Comparative Example 2 dripped immediately after application, and stained the clothes of the subject.

Evaluation 3: Treatment of wounds (1)
A carbon dioxide external preparation was prepared using 0.7 g of the granular material of the composition for preparing an external preparation of carbon dioxide of Example 3 and 15 g of a viscous composition, and 0.5 g of the external preparation was used as a barber scissor for the left ring finger of a 32-year-old male. Was applied for 20 minutes to a 1 cm long cut. This was repeated once a day for three days, and the wound was completely closed. Since the cut with the hairdressing scissors requires at least two weeks before the wound is closed with a normal adhesive bandage, the composition for preparing a carbon dioxide external preparation of the present invention has an extremely strong wound treatment effect. It is clear that can be prepared.

Evaluation 4: Treatment of wounds (2)
For a shallow skin ulcer with a long diameter of 3 cm and a short diameter of 2 cm accompanied by exudate, the granular material of the composition for preparing a carbon dioxide external preparation of Example 4 was applied to a 12-year-old male, whose incised wound was intractable and whose skin ulcer was 3 cm long and 2 cm short. An external preparation for carbon dioxide was prepared using 3 g of the viscous composition, and applied for 15 minutes. This was repeated once a day for 5 days, and the wound was completely closed without side effects.

Evaluation 5: Treatment of Acne For a 29-year-old woman with acne with a redness of about 1 mm in height at the center of the forehead, 0.7 g of a granular material of the composition for preparing an external preparation for carbon dioxide of Example 1 and a viscous composition An external preparation for carbon dioxide was prepared using 15 g of the product, and 0.5 g of the preparation was applied for 30 minutes. As a result, the reddish color became thin, and the height of acne was lowered to such an extent that the swelling was slightly recognized. Similarly, a carbon dioxide external preparation was prepared from the composition for preparing a carbon dioxide external preparation of Example 1, and 0.5 g was applied once a day for 30 minutes. The acne disappeared completely in 4 days.

Evaluation 6: Treatment of Atopic Dermatitis Granules of the composition for preparing a carbon dioxide external preparation of Example 6 for atopic dermatitis of the back of a hand of a 29-year-old man who had a dark blue color as a whole and had many scabs and bleeding An external preparation for carbon dioxide was prepared using 0.7 g of the substance and 15 g of the viscous composition, and applied to the right back for 30 minutes. As a result, the degree of blackish blue was improved, the blood color was slightly restored, and the bleeding was all stopped. Similarly, a carbon dioxide external preparation was prepared using 0.7 g of the granular material of the composition for preparing an external carbon dioxide preparation of Example 6 and 15 g of a viscous composition, and was applied for 30 minutes every day. Was completely resolved, the skin tone became normal, the number of scabs was reduced to less than half, and no bleeding was observed.

Evaluation 7: Treatment of Pigmentation After Herpes Infection For a 28-year-old woman who had had many pigmentations due to herpes infection below her left chest and continued for 2 weeks or more, the composition for preparing a carbon dioxide external preparation of Example 17 was used. An external preparation for carbon dioxide was prepared using 1.4 g of the granular material and 25 g of the viscous composition, applied to the pigmented portion, covered with a synthetic resin wrap, and allowed to stand for 30 minutes. When this was continued once a day for 3 weeks, the pigmentation became almost inconspicuous.

Evaluation 8: Treatment of nail bed defect For a 12-year-old man who had lost about 0.6 square centimeters of the left thumb nail bed with a canna, a wound dressing was used for the defect, and bleeding almost stopped on the second day. The defect was still somewhat bleeding blood and the subcutaneous tissue was visible. However, an external preparation of carbon dioxide was prepared using 0.3 g of the granular material for external preparation for carbon dioxide preparation of Example 15 and 5 g of a viscous composition. The treatment was repeated by applying a thick coating so as to cover the defect widely and sealing it with a synthetic resin wrap for one day. On the fourth day, the epithelium covered the defect, and the bleeding was completely stopped and healed.

  From these results, the composition for preparing a carbon dioxide external preparation of the present invention can easily prepare a carbon dioxide external preparation in a short time, and the prepared carbon dioxide external preparation has a sufficient viscosity, is easy to use, and can be used in a short time. It is clear that this is a composition for preparing an external preparation for carbon dioxide which can provide a powerful cosmetic and medical effect.

Claims (12)

A water-soluble acid, a thickener, a granular material in which a water-soluble dispersant, which is a substance different from the thickener, is an essential component, and the thickener is mixed with a water-soluble acid and a water-soluble dispersant,
A carbonate, water, a thickener as an essential component, and a viscous composition to be mixed with the granules at the time of use,
2 to 50% by weight of a water-soluble acid, 10 to 40% by weight of a thickener, and 30 to 85% by weight of a water-soluble dispersant based on the whole granular material;
0.1 to 10% by weight of a carbonate, 70 to 97.5% by weight of water, 0.5 to 20% by weight of a thickener based on the whole of the viscous composition,
The weight ratio of the granular material and the viscous composition is 1:10 to 40,
A composition for preparing an external carbon dioxide agent, wherein the thickener of the granular material is processed starch, dextrin and potato starch, and the water-soluble dispersant of the granular material is lactose. A water-soluble acid, a thickener, a granular material in which a water-soluble dispersant, which is a substance different from the thickener, is an essential component, and the thickener is mixed with a water-soluble acid and a water-soluble dispersant,
A carbonate, water, a thickener as an essential component, and a viscous composition to be mixed with the granules at the time of use,
2 to 50% by weight of a water-soluble acid, 10 to 40% by weight of a thickener, and 30 to 85% by weight of a water-soluble dispersant based on the whole granular material;
0.1 to 10% by weight of a carbonate, 70 to 97.5% by weight of water, 0.5 to 20% by weight of a thickener based on the whole of the viscous composition,
The weight ratio of the granular material and the viscous composition is 1:10 to 40,
A composition for preparing an external carbon dioxide agent, wherein the thickener of the granular material is dextrin and corn starch, and the water-soluble dispersant of the granular material is xylitol. A water-soluble acid, a thickener, a granular material in which a water-soluble dispersant, which is a substance different from the thickener, is an essential component, and the thickener is mixed with a water-soluble acid and a water-soluble dispersant,
A carbonate, water, a thickener as an essential component, and a viscous composition to be mixed with the granules at the time of use,
2 to 50% by weight of a water-soluble acid, 10 to 40% by weight of a thickener, and 30 to 85% by weight of a water-soluble dispersant based on the whole granular material;
0.1 to 10% by weight of a carbonate, 70 to 97.5% by weight of water, 0.5 to 20% by weight of a thickener based on the whole of the viscous composition,
The weight ratio of the granular material and the viscous composition is 1:10 to 40,
A composition for preparing an external carbon dioxide preparation, wherein the thickener of the granular material is dextrin and potato starch, and the water-soluble dispersant of the granular material is lactose. A water-soluble acid, a thickener, a granular material in which a water-soluble dispersant, which is a substance different from the thickener, is an essential component, and the thickener is mixed with a water-soluble acid and a water-soluble dispersant,
A carbonate, water, a thickener as an essential component, and a viscous composition to be mixed with the granules at the time of use,
2 to 50% by weight of a water-soluble acid, 10 to 40% by weight of a thickener, and 30 to 85% by weight of a water-soluble dispersant based on the whole granular material;
0.1 to 10% by weight of a carbonate, 70 to 97.5% by weight of water, 0.5 to 20% by weight of a thickener based on the whole of the viscous composition,
The weight ratio of the granular material and the viscous composition is 1:10 to 40,
A composition for preparing a carbon dioxide external preparation, wherein the thickener of the granular material is dextrin and potato starch, and the water-soluble dispersant of the granular material is sucrose. A water-soluble acid, a thickener, a granular material in which a water-soluble dispersant, which is a substance different from the thickener, is an essential component, and the thickener is mixed with a water-soluble acid and a water-soluble dispersant,
A carbonate, water, a thickener as an essential component, and a viscous composition to be mixed with the granules at the time of use,
2 to 50% by weight of a water-soluble acid, 10 to 40% by weight of a thickener, and 30 to 85% by weight of a water-soluble dispersant based on the whole granular material;
0.1 to 10% by weight of a carbonate, 70 to 97.5% by weight of water, 0.5 to 20% by weight of a thickener based on the whole of the viscous composition,
The weight ratio of the granular material and the viscous composition is 1:10 to 40,
The composition for preparing a carbon dioxide external preparation, wherein the thickener of the granular material is a modified starch, and the water-soluble dispersant of the granular material is lactose. A water-soluble acid, a thickener, a granular material in which a water-soluble dispersant, which is a substance different from the thickener, is an essential component, and the thickener is mixed with a water-soluble acid and a water-soluble dispersant,
A carbonate, water, a thickener as an essential component, and a viscous composition to be mixed with the granules at the time of use,
2 to 50% by weight of a water-soluble acid, 10 to 40% by weight of a thickener, and 30 to 85% by weight of a water-soluble dispersant based on the whole granular material;
0.1 to 10% by weight of a carbonate, 70 to 97.5% by weight of water, 0.5 to 20% by weight of a thickener based on the whole of the viscous composition,
The weight ratio of the granular material and the viscous composition is 1:10 to 40,
The composition for preparing a carbon dioxide external preparation, wherein the thickener of the granular material is dextrin, and the water-soluble dispersant of the granular material is sucrose. A water-soluble acid, a thickener, a granular material in which a water-soluble dispersant, which is a substance different from the thickener, is an essential component, and the thickener is mixed with a water-soluble acid and a water-soluble dispersant,
A carbonate, water, a thickener as an essential component, and a viscous composition to be mixed with the granules at the time of use,
2 to 50% by weight of a water-soluble acid, 10 to 40% by weight of a thickener, and 30 to 85% by weight of a water-soluble dispersant based on the whole granular material;
0.1 to 10% by weight of a carbonate, 70 to 97.5% by weight of water, 0.5 to 20% by weight of a thickener based on the whole of the viscous composition,
The weight ratio of the granular material and the viscous composition is 1:10 to 40,
A composition for preparing a carbon dioxide external preparation, wherein the thickener in the granules is potato starch, and the water-soluble dispersant of the granules is sucrose. A water-soluble acid, a thickener, a granular material in which a water-soluble dispersant, which is a substance different from the thickener, is an essential component, and the thickener is mixed with a water-soluble acid and a water-soluble dispersant,
A carbonate, water, a thickener as an essential component, and a viscous composition to be mixed with the granules at the time of use,
2 to 50% by weight of a water-soluble acid, 10 to 40% by weight of a thickener, and 30 to 85% by weight of a water-soluble dispersant based on the whole granular material;
0.1 to 10% by weight of a carbonate, 70 to 97.5% by weight of water, 0.5 to 20% by weight of a thickener based on the whole of the viscous composition,
The weight ratio of the granular material and the viscous composition is 1:10 to 40,
A composition for preparing an external carbon dioxide agent, wherein the thickener of the granular material is xanthan gum, dextrin and potato starch, and the water-soluble dispersant of the granular material is xylitol. A water-soluble acid, a thickener, a granular material in which a water-soluble dispersant, which is a substance different from the thickener, is an essential component, and the thickener is mixed with a water-soluble acid and a water-soluble dispersant,
A carbonate, water, a thickener as an essential component, and a viscous composition to be mixed with the granules at the time of use,
2 to 50% by weight of a water-soluble acid, 10 to 40% by weight of a thickener, and 30 to 85% by weight of a water-soluble dispersant based on the whole granular material;
0.1 to 10% by weight of a carbonate, 70 to 97.5% by weight of water, 0.5 to 20% by weight of a thickener based on the whole of the viscous composition,
The weight ratio of the granular material and the viscous composition is 1:10 to 40,
A composition for preparing an external agent for carbon dioxide, wherein the thickener of the granular material is dextrin and hydroxypropylcellulose, and the water-soluble dispersant of the granular material is D-sorbitol. A water-soluble acid, a thickener, a granular material in which a water-soluble dispersant, which is a substance different from the thickener, is an essential component, and the thickener is mixed with a water-soluble acid and a water-soluble dispersant,
A carbonate, water, a thickener as an essential component, and a viscous composition to be mixed with the granules at the time of use,
2 to 50% by weight of a water-soluble acid, 10 to 40% by weight of a thickener, and 30 to 85% by weight of a water-soluble dispersant based on the whole granular material;
0.1 to 10% by weight of a carbonate, 70 to 97.5% by weight of water, 0.5 to 20% by weight of a thickener based on the whole of the viscous composition,
The weight ratio of the granular material and the viscous composition is 1:10 to 40,
The composition for preparing a carbon dioxide external preparation, wherein the thickener of the granular material is dextrin and xanthan gum, and the water-soluble dispersant of the granular material is D-mannitol. A water-soluble acid, a thickener, a granular material in which a water-soluble dispersant, which is a substance different from the thickener, is an essential component, and the thickener is mixed with a water-soluble acid and a water-soluble dispersant,
A carbonate, water, a thickener as an essential component, and a viscous composition to be mixed with the granules at the time of use,
2 to 50% by weight of a water-soluble acid, 10 to 40% by weight of a thickener, and 30 to 85% by weight of a water-soluble dispersant based on the whole granular material;
0.1 to 10% by weight of a carbonate, 70 to 97.5% by weight of water, 0.5 to 20% by weight of a thickener based on the whole of the viscous composition,
The weight ratio of the granular material and the viscous composition is 1:10 to 40,
A composition for preparing a carbon dioxide external preparation, wherein the thickener of the granular material is xanthan gum, dextrin and hydroxypropylcellulose, and the water-soluble dispersant of the granular material is urea.   The composition for preparing a carbon dioxide external preparation according to any one of claims 1 to 11, wherein the granular material is a granule.